Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRTAP19-1	337882	broad.mit.edu	37	21	31852438	31852438	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:31852438C>A	ENST00000390689.2	-	1	225	c.199G>T	c.(199-201)Ggc>Tgc	p.G67C		NM_181607.1	NP_853638.1	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	67	26 X 2 AA repeats of G-[YCGS].					intermediate filament				cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCTCCAAAGCCAGAGCCATAT	0.512000													59	174					2.69953e-25	5.32778e-25	0.003610	1	0
KIN	22944	broad.mit.edu	37	10	7829784	7829784	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:7829784T>A	ENST00000379562.3	-	1	160	c.114_splice	c.e1+1	p.E38_splice	KIN_ENST00000543003.1_5'UTR|KIN_ENST00000535925.1_Splice_Site_p.E38_splice			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	38					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						CCCACTCACCTCGTCCCGGCA	0.647000													23	62					0	0	0.003330	0	0
SMO	6608	broad.mit.edu	37	7	128846355	128846355	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:128846355C>A	ENST00000249373.3	+	6	1471	c.1191C>A	c.(1189-1191)taC>taA	p.Y397*		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	397					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						ACAAGAACTACCGATACCGTG	0.602000			Mis		skin basal cell								30	160					2.36697e-06	3.12746e-06	0.007291	1	0
SPATA31D5P	347127	broad.mit.edu	37	9	84531715	84531715	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:84531715C>T	ENST00000527857.1	+	0	1737					NR_026851.1																						ACCCTCGCCTCAAACCCTGCC	0.512000													7	28					0	0	0.001984	0	0
PRDM16	63976	broad.mit.edu	37	1	3328481	3328481	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:3328481G>C	ENST00000378398.3	+	10	1805	c.1723G>C	c.(1723-1725)Ggg>Cgg	p.G575R	PRDM16_ENST00000511072.1_Missense_Mutation_p.G575R|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000441472.2_Missense_Mutation_p.G574R|PRDM16_ENST00000442529.2_Missense_Mutation_p.G574R|PRDM16_ENST00000514189.1_Missense_Mutation_p.G575R|PRDM16_ENST00000378391.2_Missense_Mutation_p.G574R|PRDM16_ENST00000270722.5_Missense_Mutation_p.G574R			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	574					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGCAGCTGCGGGGCCCGAGGA	0.667000			T	EVI1	"""MDS, AML"""								22	15					0	0	0.002299	0	0
ESCO2	157570	broad.mit.edu	37	8	27634552	27634552	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:27634552G>T	ENST00000305188.8	+	3	965	c.727G>T	c.(727-729)Gat>Tat	p.D243Y	ESCO2_ENST00000397418.2_5'UTR|ESCO2_ENST00000523910.1_3'UTR	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	243					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		AGTCATTGAAGATTCTGATGT	0.388000									SC Phocomelia syndrome				4	30					0.00024832	0.000288615	0.009096	1	0
C17orf74	201243	broad.mit.edu	37	17	7329778	7329778	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:7329778A>G	ENST00000333870.3	+	3	542	c.468A>G	c.(466-468)tcA>tcG	p.S156S	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	156						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				ATAGCCACTCAGTCTTCCGTA	0.602000													22	52					0	0	0.010504	0	0
GABRG1	2565	broad.mit.edu	37	4	46099325	46099325	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:46099325A>T	ENST00000295452.4	-	2	313	c.146T>A	c.(145-147)gTg>gAg	p.V49E		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	49					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GGTTTTGTTCACCGTTAAATC	0.348000													26	99					0	0	0.005443	0	0
PIGS	94005	broad.mit.edu	37	17	26883216	26883216	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:26883216C>T	ENST00000308360.7	-	10	1524	c.1149G>A	c.(1147-1149)gtG>gtA	p.V383V	PIGS_ENST00000543734.1_Silent_p.V322V|PIGS_ENST00000395346.2_Silent_p.V375V	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	383					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					CCATCACTCGCACCATGTCCA	0.507000													13	85					0	0	0.003163	0	0
SEC22A	26984	broad.mit.edu	37	3	122928212	122928212	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:122928212A>T	ENST00000309934.4	+	1	1044	c.148A>T	c.(148-150)Aga>Tga	p.R50*	SEC22A_ENST00000477063.1_3'UTR|SEC22A_ENST00000481965.2_Nonsense_Mutation_p.R50*|SEC22A_ENST00000492595.1_Nonsense_Mutation_p.R50*	NM_012430.4	NP_036562.2	Q96IW7	SC22A_HUMAN	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	50	Longin.				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			NS(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	10				GBM - Glioblastoma multiforme(114;0.0548)		ACTTCCTGATAGATGTACACT	0.358000													14	15					0	0	0.002450	0	0
CDH12	1010	broad.mit.edu	37	5	21765189	21765189	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:21765189G>T	ENST00000382254.1	-	12	2499	c.1413C>A	c.(1411-1413)agC>agA	p.S471R	CDH12_ENST00000504376.2_Missense_Mutation_p.S471R|CDH12_ENST00000522262.1_Missense_Mutation_p.S431R|CDH12_ENST00000521384.1_5'UTR|RP11-804N13.1_ENST00000522350.1_RNA	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	471	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TATTGACTTTGCTGGTCAATA	0.328000										HNSCC(59;0.17)			19	39					6.49762e-13	1.1037e-12	0.006122	1	0
GPR111	222611	broad.mit.edu	37	6	47649714	47649714	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:47649714C>A	ENST00000398742.2	+	5	1264	c.1215C>A	c.(1213-1215)agC>agA	p.S405R	GPR111_ENST00000296862.1_Missense_Mutation_p.S473R|GPR111_ENST00000507065.1_Missense_Mutation_p.S405R			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	473	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TAGTCTGGAGCCAAGTGACAA	0.453000													25	50					1.1804e-14	2.10925e-14	0.003954	1	0
KIAA0947	23379	broad.mit.edu	37	5	5461238	5461238	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:5461238A>G	ENST00000296564.7	+	13	2013	c.1791A>G	c.(1789-1791)gaA>gaG	p.E597E		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	597										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						AGGAAAAAGAAGATACTCAAG	0.398000													19	227					0	0	0.008871	0	0
FBLL1	345630	broad.mit.edu	37	5	167957216	167957216	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:167957216G>A	ENST00000338333.4	+	1	1096	c.707G>A	c.(706-708)cGc>cAc	p.R236H																								CTCAAGTACCGCATGCTCATC	0.662000													5	22					0	0	0.000602	0	0
ELMO1	9844	broad.mit.edu	37	7	37354510	37354510	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:37354510G>T	ENST00000310758.4	-	4	783	c.136C>A	c.(136-138)Cat>Aat	p.H46N	ELMO1_ENST00000442504.1_Missense_Mutation_p.H46N|ELMO1_ENST00000448602.1_Missense_Mutation_p.H46N	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	46					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						AAATATTCATGGTTGGCAAGA	0.328000													10	6					7.48243e-07	1.01278e-06	0.006214	1	0
SUN5	140732	broad.mit.edu	37	20	31583529	31583529	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:31583529A>T	ENST00000356173.3	-	8	522	c.430T>A	c.(430-432)Tac>Aac	p.Y144N	SUN5_ENST00000375523.3_Missense_Mutation_p.Y119N	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	144					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						TTCTCCTGGTACAACCTTATC	0.483000													64	116					0	0	0.003610	0	0
DEFB110	245913	broad.mit.edu	37	6	49986759	49986759	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:49986759C>A	ENST00000371148.2	-	2	180	c.135G>T	c.(133-135)caG>caT	p.Q45H	DEFB110_ENST00000393660.2_Intron	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	45					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					TTTCATGACACTGATTTTTAC	0.403000													27	41					4.7796e-09	7.16941e-09	0.004656	1	0
OLFM3	118427	broad.mit.edu	37	1	102296235	102296235	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:102296235T>A	ENST00000370103.4	-	3	578	c.365A>T	c.(364-366)cAt>cTt	p.H122L	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000359814.3_Missense_Mutation_p.H142L|OLFM3_ENST00000338858.5_Missense_Mutation_p.H142L|OLFM3_ENST00000536598.1_Missense_Mutation_p.H47L	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	142						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TACCTGAAAATGCTTGGTCAT	0.408000													14	59					0	0	0.004007	0	0
ARAF	369	broad.mit.edu	37	X	47424443	47424443	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:47424443T>C	ENST00000377045.4	+	5	557	c.363T>C	c.(361-363)caT>caC	p.H121H	ARAF_ENST00000290277.6_Silent_p.H121H|ARAF_ENST00000377039.2_Silent_p.H121H	NM_001256196.1|NM_001654.4	NP_001243125.1|NP_001645.1	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene homolog	121					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			biliary_tract(1)|endometrium(4)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	29					Adenosine triphosphate(DB00171)	TTCTGTTCCATGGCTTCCGTT	0.522000													14	47					0	0	0.004990	0	0
ZNF273	10793	broad.mit.edu	37	7	64388439	64388439	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:64388439C>A	ENST00000476120.1	+	4	804	c.733C>A	c.(733-735)Cag>Aag	p.Q245K	ZNF273_ENST00000527278.1_3'UTR|ZNF273_ENST00000319636.5_Missense_Mutation_p.Q180K	NM_021148.2	NP_066971.2	Q14593	ZN273_HUMAN	zinc finger protein 273	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Lung NSC(55;0.0295)|all_lung(88;0.0691)				AGCCTTTAACCAGTTCTCAAA	0.353000													12	73					3.07112e-06	4.01769e-06	0.010729	1	0
FGF6	2251	broad.mit.edu	37	12	4554610	4554610	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:4554610G>T	ENST00000228837.2	-	1	170	c.127C>A	c.(127-129)Cgt>Agt	p.R43S		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	43					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TTGTTGGCACGGGTGCCTGCA	0.662000													26	31					1.1804e-14	2.10925e-14	0.003954	1	0
LCE3B	353143	broad.mit.edu	37	1	152586433	152586433	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152586433T>A	ENST00000335633.1	+	1	147	c.147T>A	c.(145-147)tcT>tcA	p.S49S		NM_178433.1	NP_848520.1	Q5TA77	LCE3B_HUMAN	late cornified envelope 3B	49	Cys-rich.				keratinization					large_intestine(1)|lung(2)|prostate(1)	4	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		GCCCCAGCTCTGAGGGCGGCT	0.657000													16	80					0	0	0.003163	0	0
FSHR	2492	broad.mit.edu	37	2	49216144	49216144	+	Missense_Mutation	SNP	C	C	A	rs142383710	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:49216144C>A	ENST00000406846.2	-	6	615	c.496G>T	c.(496-498)Gtg>Ttg	p.V166L	FSHR_ENST00000346173.3_Missense_Mutation_p.V166L|FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000304421.4_Intron	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	166					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding	p.V166L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CTCAGCCCCACGAAAGAATTT	0.338000									Gonadal Dysgenesis, 46 XX				12	14					6.40141e-05	7.73298e-05	0.010729	1	0
ATF6B	1388	broad.mit.edu	37	6	32087620	32087620	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:32087620G>A	ENST00000375201.4	-	9	983	c.938C>T	c.(937-939)tCc>tTc	p.S313F	ATF6B_ENST00000375203.3_Missense_Mutation_p.S316F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	316					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						AGGCGGGCAGGAGTTTCCAGG	0.577000													15	53					0	0	0.004007	0	0
KCNJ2	3759	broad.mit.edu	37	17	68172348	68172348	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:68172348A>T	ENST00000243457.3	+	2	1551	c.1168A>T	c.(1168-1170)Agt>Tgt	p.S390C	KCNJ2_ENST00000535240.1_Missense_Mutation_p.S390C	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	390					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					GGAAGACGACAGTGAAAATGG	0.463000													23	89					0	0	0.002299	0	0
FAM194A	131831	broad.mit.edu	37	3	150403781	150403781	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:150403781G>A	ENST00000295910.6	-	5	690	c.638C>T	c.(637-639)tCg>tTg	p.S213L	FAM194A_ENST00000491361.1_Missense_Mutation_p.S67L	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	213										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						ATTTAGTTTCGACTCTTCTGG	0.308000													16	41					0	0	0.004007	0	0
RAG1	5896	broad.mit.edu	37	11	36597194	36597194	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:36597194A>T	ENST00000299440.5	+	2	2452	c.2340A>T	c.(2338-2340)aaA>aaT	p.K780N		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	780					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ATCGGGTGAAAGGGGTCTCAG	0.493000									Familial Hemophagocytic Lymphohistiocytosis				17	75					0	0	0.004990	0	0
ITFG2	55846	broad.mit.edu	37	12	2932953	2932953	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:2932953G>T	ENST00000228799.2	+	11	1223	c.1084G>T	c.(1084-1086)Gag>Tag	p.E362*	ITFG2_ENST00000542548.1_Nonsense_Mutation_p.E250*|ITFG2_ENST00000419778.2_Nonsense_Mutation_p.E185*	NM_018463.3	NP_060933.3	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	362										central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CGCCTGCAAAGAGGGCCGCAA	0.552000													42	169					7.05121e-23	1.36806e-22	0.010771	1	0
OTOGL	283310	broad.mit.edu	37	12	80752087	80752087	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:80752087G>T	ENST00000458043.2	+	49	6058	c.6052G>T	c.(6052-6054)Gat>Tat	p.D2018Y	OTOGL_ENST00000546620.1_Missense_Mutation_p.D37Y|OTOGL_ENST00000547103.1_Missense_Mutation_p.D2006Y	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCTCACAGTAGATCTTAATAG	0.358000													8	15					1.58986e-06	2.11859e-06	0.008291	1	0
NCSTN	23385	broad.mit.edu	37	1	160313244	160313244	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:160313244C>G	ENST00000294785.5	+	1	183	c.58C>G	c.(58-60)Ctt>Gtt	p.L20V	NCSTN_ENST00000535857.1_Missense_Mutation_p.L20V|NCSTN_ENST00000368063.1_5'UTR	NM_015331.2	NP_056146.1	Q92542	NICA_HUMAN	nicastrin	20					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTCCTTCGCCTTCTGTCTTT	0.667000													7	21					0	0	0.003080	0	0
LRAT	9227	broad.mit.edu	37	4	155666013	155666013	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:155666013G>C	ENST00000336356.3	+	2	788	c.535G>C	c.(535-537)Gac>Cac	p.D179H	LRAT_ENST00000507827.1_Missense_Mutation_p.D179H	NM_004744.3	NP_004735.2	O95237	LRAT_HUMAN	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	179					response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)	16	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	TCCCCAGTCCGACAAGGTATG	0.577000													15	49					0	0	0.008871	0	0
LEPR	3953	broad.mit.edu	37	1	66083808	66083808	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:66083808G>C	ENST00000349533.6	+	16	2559	c.2374G>C	c.(2374-2376)Gtt>Ctt	p.V792L	LEPR_ENST00000344610.8_Missense_Mutation_p.V792L|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371058.1_Missense_Mutation_p.V792L|LEPR_ENST00000371059.3_Missense_Mutation_p.V792L|LEPR_ENST00000371060.3_Missense_Mutation_p.V792L	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	792	Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTCTTCATCTGTTAAGAAGTA	0.284000													14	47					0	0	0.002450	0	0
SLC6A15	55117	broad.mit.edu	37	12	85270331	85270331	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:85270331C>A	ENST00000266682.5	-	6	1353	c.812G>T	c.(811-813)aGa>aTa	p.R271I	SLC6A15_ENST00000552192.1_Missense_Mutation_p.R164I|SLC6A15_ENST00000551388.1_5'UTR	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	271					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						AAGGAATGCTCTGATGAGGAA	0.318000													19	34					2.32416e-17	4.29133e-17	0.002299	1	0
ANO1	55107	broad.mit.edu	37	11	70007788	70007788	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:70007788A>G	ENST00000355303.5	+	18	2146	c.1841A>G	c.(1840-1842)aAg>aGg	p.K614R	ANO1_ENST00000538023.1_Missense_Mutation_p.K614R|ANO1_ENST00000530676.1_Missense_Mutation_p.K468R|ANO1_ENST00000531349.1_Missense_Mutation_p.K323R|ANO1_ENST00000398543.2_Missense_Mutation_p.K468R|ANO1_ENST00000316296.5_Missense_Mutation_p.K556R	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	614					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TTCCTGCTGAAGTTTGTGAAT	0.537000													24	107					0	0	0.002780	0	0
C8orf86	389649	broad.mit.edu	37	8	38369939	38369939	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:38369939C>A	ENST00000358138.1	-	3	662	c.638G>T	c.(637-639)gGg>gTg	p.G213V	C8orf86_ENST00000437935.2_3'UTR	NM_207412.1	NP_997295.1	Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	213										breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						cacctgtgccccagaaagcac	0.547000													9	26					0.000274275	0.000316429	0.004482	1	0
FMN1	342184	broad.mit.edu	37	15	33261322	33261322	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:33261322C>A	ENST00000334528.9	-	4	1910	c.1911G>T	c.(1909-1911)atG>atT	p.M637I	FMN1_ENST00000561249.1_Missense_Mutation_p.M762I|FMN1_ENST00000559047.1_Missense_Mutation_p.M860I	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	860	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GATTTGATGCCATGCCCTCCA	0.547000													10	24					1.08611e-07	1.52534e-07	0.010729	1	0
UTP15	84135	broad.mit.edu	37	5	72875896	72875896	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:72875896G>T	ENST00000296792.4	+	13	1789	c.1534G>T	c.(1534-1536)Gag>Tag	p.E512*	UTP15_ENST00000508491.1_Nonsense_Mutation_p.E493*|UTP15_ENST00000543251.1_Nonsense_Mutation_p.E322*	NM_032175.2	NP_115551.2	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	512					rRNA processing	cytoplasm|nucleolus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	15		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TGGATTTCCAGAGAATAAGAA	0.383000													4	45					3.59834e-05	4.44363e-05	0.001168	1	0
RNF213	57674	broad.mit.edu	37	17	78316967	78316967	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:78316967A>G	ENST00000582970.1	+	27	6168	c.6025A>G	c.(6025-6027)Atg>Gtg	p.M2009V	RNF213_ENST00000336301.6_Missense_Mutation_p.M82V|RNF213_ENST00000508628.2_Missense_Mutation_p.M2058V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCACGACAAAATGAAGATGCA	0.478000													9	37					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9063543	9063543	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9063543G>C	ENST00000397910.4	-	3	24106	c.23903C>G	c.(23902-23904)aCt>aGt	p.T7968S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7970	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGTCTAGTTTTTTCCAG	0.468000													11	15					0	0	0.008291	0	0
ZNF208	7757	broad.mit.edu	37	19	22155018	22155018	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:22155018C>T	ENST00000397126.4	-	4	2966	c.2818G>A	c.(2818-2820)Gct>Act	p.A940T	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTCTCTCCAGCATGAGTTTTC	0.373000													5	19					0	0	0.000602	0	0
MGAT1	4245	broad.mit.edu	37	5	180219260	180219260	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:180219260C>A	ENST00000446023.2	-	3	1462	c.712G>T	c.(712-714)Gtc>Ttc	p.V238F	MGAT1_ENST00000307826.4_Missense_Mutation_p.V238F|MGAT1_ENST00000427865.2_Missense_Mutation_p.V238F|MGAT1_ENST00000333055.3_Missense_Mutation_p.V238F|MGAT1_ENST00000393340.3_Missense_Mutation_p.V238F	NM_001114617.1|NM_001114618.1	NP_001108089.1|NP_001108090.1	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	238					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			endometrium(1)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	13	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGCCGAGACGCACCACAGG	0.647000													16	44					3.41278e-10	5.3284e-10	0.004990	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54910700	54910700	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:54910700G>T	ENST00000293373.6	+	11	1098	c.1019G>T	c.(1018-1020)cGg>cTg	p.R340L	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R290L	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	340					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CATTGTCAACGGCGGCAATTT	0.507000													20	76					3.51602e-12	5.84529e-12	0.008871	1	0
GRPR	2925	broad.mit.edu	37	X	16170424	16170424	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:16170424G>T	ENST00000380289.2	+	3	1209	c.811G>T	c.(811-813)Ggc>Tgc	p.G271C		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	271					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					GGTGTTTGTGGGCCTGTTCGC	0.532000													40	39					1.96642e-18	3.67022e-18	0.006999	1	0
TRBV25-1	28562	broad.mit.edu	37	7	142378658	142378658	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:142378658G>T	ENST00000390398.3	+	0	86																											CTGGGGGCAGGTAAGTCATAG	0.478000													7	23					8.12818e-05	9.70302e-05	0.001984	1	0
TXNDC2	84203	broad.mit.edu	37	18	9887046	9887046	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:9887046G>A	ENST00000306084.6	+	2	769	c.570G>A	c.(568-570)aaG>aaA	p.K190K	TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000357775.4_Silent_p.K123K	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	190	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						TCCAATCCAAGAAGGAGGACC	0.572000													29	51					0	0	0.008361	0	0
SLC5A8	160728	broad.mit.edu	37	12	101551060	101551060	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:101551060C>T	ENST00000536262.2	-	15	2388	c.1830G>A	c.(1828-1830)ttG>ttA	p.L610L		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	610					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGCAGCTTCACAAACGAGTCC	0.373000													4	22					0	0	0.009096	0	0
NUP35	129401	broad.mit.edu	37	2	184024234	184024234	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:184024234G>A	ENST00000295119.4	+	8	860	c.757G>A	c.(757-759)Gac>Aac	p.D253N	NUP35_ENST00000541912.1_Missense_Mutation_p.D118N|NUP35_ENST00000409798.1_Missense_Mutation_p.D236N	NM_138285.3	NP_612142.2	Q8NFH5	NUP53_HUMAN	nucleoporin 35kDa	253					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8						GGAAAGCAGTGACAGATGTGC	0.348000													11	29					0	0	0.001855	0	0
LILRB4	11006	broad.mit.edu	37	19	55175231	55175231	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:55175231C>A	ENST00000391736.1	+	5	405	c.90C>A	c.(88-90)acC>acA	p.T30T	LILRB4_ENST00000430952.2_Silent_p.T30T|LILRB4_ENST00000391733.3_Silent_p.T30T|LILRB4_ENST00000391734.3_Silent_p.T30T|LILRB4_ENST00000270452.2_Silent_p.T30T	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	30	Ig-like C2-type 1.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CCAAACCCACCCTCTGGGCTG	0.622000													12	48					0.00010058	0.000119569	0.001368	1	0
TMC8	147138	broad.mit.edu	37	17	76135285	76135285	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:76135285C>T	ENST00000318430.5	+	15	2240	c.1866C>T	c.(1864-1866)gcC>gcT	p.A622A	TMC8_ENST00000589691.1_Silent_p.A399A|TMC8_ENST00000591144.1_3'UTR	NM_152468.4	NP_689681.2	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	622						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			AGGCCAATGCCAGGGCCATCC	0.647000													7	79					0	0	0.004482	0	0
MAP3K4	4216	broad.mit.edu	37	6	161470144	161470144	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:161470144G>T	ENST00000392142.4	+	3	988	c.840G>T	c.(838-840)caG>caT	p.Q280H	MAP3K4_ENST00000366920.2_Missense_Mutation_p.Q280H|MAP3K4_ENST00000348824.7_Missense_Mutation_p.Q280H|MAP3K4_ENST00000366919.2_Missense_Mutation_p.Q280H	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	280					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TTAACGACCAGGACTTCTTTT	0.428000													4	34					2.56e-06	3.37731e-06	0.009096	1	0
MYO1C	4641	broad.mit.edu	37	17	1371772	1371772	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:1371772C>A	ENST00000359786.5	-	26	2953	c.2629G>T	c.(2629-2631)Gct>Tct	p.A877S	MYO1C_ENST00000575158.1_Missense_Mutation_p.A842S|MYO1C_ENST00000361007.2_Missense_Mutation_p.A842S|MYO1C_ENST00000545534.2_Missense_Mutation_p.A853S|MYO1C_ENST00000438665.2_Missense_Mutation_p.A858S	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	877					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ATCTCACTAGCCACGGCCTTC	0.582000													11	29					1.58986e-06	2.11859e-06	0.008291	1	0
ZNF518B	85460	broad.mit.edu	37	4	10446546	10446546	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:10446546C>A	ENST00000326756.3	-	3	1845	c.1407G>T	c.(1405-1407)ttG>ttT	p.L469F		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TATGTGGATACAAATTATTTT	0.333000													5	22					0.00116845	0.00130426	0.001168	1	0
NIPBL	25836	broad.mit.edu	37	5	36962328	36962328	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:36962328C>T	ENST00000282516.8	+	6	1061	c.562C>T	c.(562-564)Cca>Tca	p.P188S	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Missense_Mutation_p.P188S	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	188					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGGATACATGCCATATTCCCA	0.453000													40	283					0	0	0.009718	0	0
DOCK2	1794	broad.mit.edu	37	5	169507218	169507218	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:169507218G>A	ENST00000256935.8	+	50	5298	c.5218G>A	c.(5218-5220)Gcc>Acc	p.A1740T	DOCK2_ENST00000520908.1_Missense_Mutation_p.A1232T|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.A801T	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1740					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAGCATGCGGCCATCCCCCT	0.557000													10	29					0	0	0.006214	0	0
PIK3CA	5290	broad.mit.edu	37	3	178947861	178947861	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:178947861A>T	ENST00000263967.3	+	19	2893	c.2736A>T	c.(2734-2736)ggA>ggT	p.G912G		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	912	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATTTTGGGAATTGGAGATC	0.363000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	118					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179486621	179486621	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179486621C>G	ENST00000589042.1	-	244	45252	c.45028G>C	c.(45028-45030)Gaa>Caa	p.E15010Q	TTN_ENST00000342175.6_Missense_Mutation_p.E6137Q|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E5945Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E6070Q|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E13369Q|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E12442Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13369	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGAATATTCAGCTTCATCA	0.393000													11	63					0	0	0.010729	0	0
INSR	3643	broad.mit.edu	37	19	7143017	7143017	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:7143017G>A	ENST00000341500.5	-	11	2355	c.2316C>T	c.(2314-2316)tcC>tcT	p.S772S	INSR_ENST00000302850.5_Silent_p.S784S	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	784	Fibronectin type-III 2.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCTGGTCGAGGAAGTGTTGG	0.612000													5	33					0	0	0.000602	0	0
ABTB2	25841	broad.mit.edu	37	11	34181802	34181802	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:34181802G>T	ENST00000435224.2	-	12	2920	c.2496C>A	c.(2494-2496)gcC>gcA	p.A832A	ABTB2_ENST00000298992.2_Silent_p.A646A	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	646							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CACCTAGCCTGGCCGGCAGGG	0.602000													14	29					4.3838e-07	5.98551e-07	0.001855	1	0
SALL1	6299	broad.mit.edu	37	16	51171213	51171213	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:51171213G>T	ENST00000440970.1	-	3	3925	c.3494C>A	c.(3493-3495)cCa>cAa	p.P1165Q	SALL1_ENST00000541611.1_Missense_Mutation_p.P85Q|SALL1_ENST00000566102.1_3'UTR|SALL1_ENST00000251020.4_Missense_Mutation_p.P1262Q	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1262					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCCAGGAATTGGAGGGATGCC	0.587000													17	28					9.16793e-09	1.35625e-08	0.004990	1	0
UCKL1	54963	broad.mit.edu	37	20	62571609	62571609	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:62571609T>A	ENST00000369908.5	-	14	1715	c.1416A>T	c.(1414-1416)gcA>gcT	p.A472A	UCKL1_ENST00000354216.6_Silent_p.A487A|UCKL1_ENST00000358711.3_3'UTR|UCKL1_ENST00000369892.3_Silent_p.A487A	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	487					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CGCCCATCTCTGCCATGAGCA	0.567000													13	40					0	0	0.002450	0	0
PRR12	57479	broad.mit.edu	37	19	50100115	50100115	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:50100115G>T	ENST00000418929.2	+	4	2535	c.2523G>T	c.(2521-2523)ccG>ccT	p.P841P		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	20							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGCCACCCCCGCCTCCACCAC	0.746000													3	4					0.00909568	0.00969341	0.009096	1	0
C6orf118	168090	broad.mit.edu	37	6	165715190	165715190	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:165715190G>T	ENST00000543069.1	-	2	890	c.309C>A	c.(307-309)gcC>gcA	p.A103A	C6orf118_ENST00000230301.8_Silent_p.A207A			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	207										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TGGTGGCTCCGGCCAGGTAGG	0.602000													12	49					1.08611e-07	1.52534e-07	0.010729	1	0
SEMA5A	9037	broad.mit.edu	37	5	9066568	9066568	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:9066568C>A	ENST00000382496.5	-	17	2929	c.2264G>T	c.(2263-2265)tGt>tTt	p.C755F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	755	TSP type-1 4.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GTCGCTAGAACAGTACCGCAT	0.537000													44	293					7.88023e-25	1.5499e-24	0.003610	1	0
DISP2	85455	broad.mit.edu	37	15	40657469	40657469	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:40657469C>A	ENST00000267889.3	+	6	928	c.841C>A	c.(841-843)Ccc>Acc	p.P281T		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	281					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CTTCTGTGGCCCCCCTGGTAA	0.607000													4	27					0.000602214	0.000681505	0.000602	1	0
HSF5	124535	broad.mit.edu	37	17	56544284	56544284	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:56544284G>T	ENST00000323777.3	-	3	1091	c.982C>A	c.(982-984)Ccc>Acc	p.P328T		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	328						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGGCATTGGGAGTGACACAA	0.443000													20	69					7.87624e-14	1.37454e-13	0.002780	1	0
WDR59	79726	broad.mit.edu	37	16	74943460	74943460	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:74943460C>T	ENST00000262144.6	-	16	1711	c.1581G>A	c.(1579-1581)ggG>ggA	p.G527G		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	527										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CCTGGTACGACCCGTAAGCCG	0.567000													25	65					0	0	0.004656	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162850	33162850	+	RNA	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:33162850T>A	ENST00000510327.1	-	0	346																											CAGATGGCTATGTGCTAGAGG	0.488000													26	9					0	0	0.003330	0	0
UQCRC1	7384	broad.mit.edu	37	3	48643287	48643287	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:48643287C>T	ENST00000203407.5	-	3	629	c.213G>A	c.(211-213)gtG>gtA	p.V71V		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	71					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	TCCACACTCCCACCTGGTCAA	0.517000													12	37					0	0	0.001368	0	0
TRIM48	79097	broad.mit.edu	37	11	55032683	55032683	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55032683A>G	ENST00000417545.2	+	2	438	c.352A>G	c.(352-354)Atg>Gtg	p.M118V		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	102						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GACAAAGAAGATGTTCTGTGA	0.532000													7	58					0	0	0.001984	0	0
ZIC1	7545	broad.mit.edu	37	3	147131292	147131292	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:147131292C>A	ENST00000282928.4	+	3	2027	c.1298C>A	c.(1297-1299)gCc>gAc	p.A433D		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	433	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CACCACACAGCCGGCCACAGT	0.512000													9	48					0.000274275	0.000316429	0.004482	1	0
NUTM2A-AS1	728190	broad.mit.edu	37	10	88975906	88975906	+	RNA	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:88975906A>G	ENST00000451940.2	-	0	600																											GTTGTGGTTCATCAGAGACAC	0.557000													7	13					0	0	0.004482	0	0
KLHL10	317719	broad.mit.edu	37	17	40001920	40001920	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:40001920G>A	ENST00000293303.4	+	3	1380	c.1227G>A	c.(1225-1227)gaG>gaA	p.E409E		NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	409						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				ATGAGCCAGAGACCAATCAAT	0.502000													16	63					0	0	0.004007	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29976208	29976208	+	RNA	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:29976208G>C	ENST00000376797.3	-	0	1053				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							TGCAGCACAAGGGGCTGCCCA	0.587000													9	37					0	0	0.004482	0	0
LOC101928517	101928517	broad.mit.edu	37	19	51670964	51670964	+	RNA	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51670964A>G	ENST00000600074.1	-	0	493				SIGLEC17P_ENST00000598286.1_RNA																							TCAACTCAAAAAGTGCAGAAG	0.557000													4	10					0	0	0.009096	0	0
SAMD3	154075	broad.mit.edu	37	6	130505706	130505706	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:130505706A>T	ENST00000532763.1	-	5	569	c.440T>A	c.(439-441)tTa>tAa	p.L147*	SAMD3_ENST00000324172.6_Nonsense_Mutation_p.L149*|SAMD3_ENST00000457563.2_Nonsense_Mutation_p.L173*|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000439090.2_Nonsense_Mutation_p.L149*|SAMD3_ENST00000437477.2_Nonsense_Mutation_p.L149*|SAMD3_ENST00000368134.2_Nonsense_Mutation_p.L149*			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	149										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AAACTCTGGTAAAACATAGGA	0.398000													6	30					0	0	0.001984	0	0
PASD1	139135	broad.mit.edu	37	X	150773156	150773156	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:150773156T>A	ENST00000370357.4	+	3	312	c.67T>A	c.(67-69)Tgg>Agg	p.W23R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	23						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GAAATTAAACTGGATTCCATC	0.333000													4	5					0	0	0.009096	0	0
BSPRY	54836	broad.mit.edu	37	9	116132008	116132008	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:116132008C>T	ENST00000374183.4	+	6	834	c.795C>T	c.(793-795)ggC>ggT	p.G265G	BSPRY_ENST00000462085.1_3'UTR	NM_017688.2	NP_060158.2	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	265	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						GTGCAGATGGCCCGGAGCGCT	0.557000													14	37					0	0	0.002450	0	0
ZC3H18	124245	broad.mit.edu	37	16	88695191	88695191	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:88695191G>T	ENST00000301011.5	+	16	2695	c.2495G>T	c.(2494-2496)cGc>cTc	p.R832L	ZC3H18_ENST00000452588.2_Missense_Mutation_p.R856L	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	832						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGCAGGAAGCGCTATGAACCA	0.642000													18	131					6.94344e-10	1.06951e-09	0.006122	1	0
RELN	5649	broad.mit.edu	37	7	103206745	103206745	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:103206745T>C	ENST00000428762.1	-	33	5021	c.4862A>G	c.(4861-4863)tAt>tGt	p.Y1621C	RELN_ENST00000343529.5_Missense_Mutation_p.Y1621C|RELN_ENST00000424685.2_Missense_Mutation_p.Y1621C	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1621					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTGGATTCGATACCAGTTGGC	0.388000													11	44					0	0	0.008291	0	0
AGPS	8540	broad.mit.edu	37	2	178310322	178310322	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:178310322G>T	ENST00000264167.4	+	8	984	c.838G>T	c.(838-840)Gct>Tct	p.A280S	AGPS_ENST00000409888.1_Intron	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase	280	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TCATGTAGAGGCTGGCATAAC	0.313000													4	35					0.000602214	0.000681505	0.000602	1	0
CHRNB2	1141	broad.mit.edu	37	1	154544056	154544056	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:154544056A>T	ENST00000368476.3	+	5	1021	c.757A>T	c.(757-759)Atc>Ttc	p.I253F		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	253					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	CTCGCTAGCCATCCTTGTCTT	0.537000													78	70					0	0	0.003610	0	0
ZNF558	148156	broad.mit.edu	37	19	8922257	8922257	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:8922257C>A	ENST00000601372.1	-	10	1620	c.909G>T	c.(907-909)aaG>aaT	p.K303N	ZNF558_ENST00000444186.2_Missense_Mutation_p.K232N|ZNF558_ENST00000301475.1_Missense_Mutation_p.K303N			Q96NG5	ZN558_HUMAN	zinc finger protein 558	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						GATAGGAGCTCTTCCTGAAGG	0.443000													20	46					6.44725e-10	9.94868e-10	0.002299	1	0
FCRLB	127943	broad.mit.edu	37	1	161693363	161693363	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:161693363A>G	ENST00000367948.2	+	5	474	c.259A>G	c.(259-261)Aca>Gca	p.T87A	FCRLB_ENST00000367946.3_Missense_Mutation_p.T87A|FCRLB_ENST00000367945.1_Missense_Mutation_p.T80A|FCRLB_ENST00000336830.5_Missense_Mutation_p.T87A|FCRLB_ENST00000392158.1_Missense_Mutation_p.T87A|FCRLB_ENST00000367944.3_Missense_Mutation_p.T80A			Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	87	Ig-like C2-type 1.					endoplasmic reticulum				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|skin(1)	17	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TCGATGCCAGACACGGGGAGC	0.582000													13	42					0	0	0.001855	0	0
TTN	7273	broad.mit.edu	37	2	179449937	179449937	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179449937G>T	ENST00000589042.1	-	309	64758	c.64534C>A	c.(64534-64536)Cac>Aac	p.H21512N	TTN_ENST00000342175.6_Missense_Mutation_p.H12639N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.H12447N|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.H12572N|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.H19871N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.H18944N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19871	Fibronectin type-III 56.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGCCAGGTGGCTGGATGTG	0.443000													202	223					3.48826e-88	7.05449e-88	0.003610	1	0
SEC1P	653677	broad.mit.edu	37	19	49183658	49183658	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:49183658C>A	ENST00000430145.2	+	0	745					NR_004401.2																						ACCACCTGAACGACTGGATGG	0.657000													10	16					3.86212e-05	4.72862e-05	0.008291	1	0
EIF3B	8662	broad.mit.edu	37	7	2416670	2416670	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:2416670G>T	ENST00000360876.4	+	15	2170	c.2114G>T	c.(2113-2115)cGg>cTg	p.R705L	EIF3B_ENST00000397011.2_Missense_Mutation_p.R705L	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	705					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTGCTGTGGCGGCCCCGGCCT	0.632000													8	25					1.12685e-05	1.4264e-05	0.004482	1	0
ADTRP	84830	broad.mit.edu	37	6	11723638	11723638	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:11723638T>A	ENST00000414691.3	-	5	1012	c.602A>T	c.(601-603)tAc>tTc	p.Y201F	ADTRP_ENST00000229583.5_Missense_Mutation_p.Y219F|ADTRP_ENST00000514824.1_5'UTR|ADTRP_ENST00000379413.2_Missense_Mutation_p.Y201F	NM_032744.3	NP_116133.1	Q96IZ2	CF105_HUMAN	androgen-dependent TFPI-regulating protein	201						integral to membrane											GATGAAGACGTAGCTGAGAGA	0.493000													33	153					0	0	0.002836	0	0
XIRP2	129446	broad.mit.edu	37	2	168099387	168099387	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168099387G>A	ENST00000409195.1	+	9	1574	c.1485G>A	c.(1483-1485)ttG>ttA	p.L495L	XIRP2_ENST00000409273.1_Silent_p.L273L|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.L495L|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	320					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAAGAAATTTGTATGAATTAA	0.363000													6	30					0	0	0.001984	0	0
LRRC7	57554	broad.mit.edu	37	1	70478690	70478690	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:70478690C>A	ENST00000310961.5	+	14	1487	c.1069C>A	c.(1069-1071)Cta>Ata	p.L357I	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.L352I			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	352						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGTCATGTCTCTACGCTCCAA	0.313000													37	85					1.22674e-20	2.3483e-20	0.008740	1	0
GGN	199720	broad.mit.edu	37	19	38876354	38876354	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:38876354G>T	ENST00000334928.6	-	3	1680	c.1548C>A	c.(1546-1548)ccC>ccA	p.P516P	AC005789.9_ENST00000585411.1_RNA|GGN_ENST00000591809.1_Intron	NM_152657.3	NP_689870.3	Q86UU5	GGN_HUMAN	gametogenetin	516	Interactions with ZNF403/GGNBP2 and OAZ3 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			gcgcagccgcgggtgcgggcg	0.736000													10	17					2.80697e-09	4.24753e-09	0.010729	1	0
ID2	3398	broad.mit.edu	37	2	8823008	8823008	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:8823008C>G	ENST00000234091.4	+	4	1244	c.384C>G	c.(382-384)gaC>gaG	p.D128E	ID2_ENST00000331129.3_Missense_Mutation_p.D128E|ID2_ENST00000396290.1_Missense_Mutation_p.D128E			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	128					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGTCAAATGACAGCAAAGCAC	0.458000													11	69					0	0	0.002450	0	0
ZNF831	128611	broad.mit.edu	37	20	57769446	57769446	+	Silent	SNP	G	G	A	rs150212573	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:57769446G>A	ENST00000371030.2	+	1	3372	c.3372G>A	c.(3370-3372)ccG>ccA	p.P1124P		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1124						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCCCGACCCGTGTTCCCCCC	0.667000													6	39					0	0	0.001984	0	0
OR2M3	127062	broad.mit.edu	37	1	248367101	248367101	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248367101C>A	ENST00000456743.1	+	1	770	c.732C>A	c.(730-732)caC>caA	p.H244Q		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTTCCTCTCACCTCTTGGTGG	0.478000													36	170					2.47316e-13	4.24287e-13	0.003271	1	0
CHRNA1	1134	broad.mit.edu	37	2	175612944	175612944	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:175612944G>A	ENST00000348749.5	-	9	1359	c.1282C>T	c.(1282-1284)Cac>Tac	p.H428Y	CHRNA1_ENST00000261007.5_Missense_Mutation_p.H453Y|CHRNA1_ENST00000409542.1_Missense_Mutation_p.H346Y|CHRNA1_ENST00000409219.1_Missense_Mutation_p.H348Y|AC018890.6_ENST00000442996.1_RNA	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	453					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						AGGAGTATGTGGTCCATCACC	0.488000													13	54					0	0	0.001368	0	0
FOXB2	442425	broad.mit.edu	37	9	79635203	79635203	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:79635203G>C	ENST00000376708.1	+	1	633	c.633G>C	c.(631-633)ccG>ccC	p.P211P		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	211					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						CTCAGCAGCCGTCTCACCCCG	0.736000													3	6					0	0	0.004672	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956659	102956659	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:102956659C>A	ENST00000311734.2	+	4	713	c.374C>A	c.(373-375)tCa>tAa	p.S125*	IL1RL1_ENST00000393393.3_Nonsense_Mutation_p.S125*|IL1RL1_ENST00000409584.1_Nonsense_Mutation_p.S125*|IL1RL1_ENST00000233954.1_Nonsense_Mutation_p.S125*|IL1RL1_ENST00000404917.2_Nonsense_Mutation_p.S8*			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	125	Ig-like C2-type 2.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						GTATCTGGATCAGAAAAAAAT	0.348000													3	18					0.004672	0.0050606	0.004672	1	0
RSPO1	284654	broad.mit.edu	37	1	38095317	38095317	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:38095317C>A	ENST00000356545.2	-	4	804	c.17G>T	c.(16-18)tGt>tTt	p.C6F	RSPO1_ENST00000401068.1_Missense_Mutation_p.C6F|RSPO1_ENST00000373059.1_Intron|RSPO1_ENST00000401070.1_Missense_Mutation_p.C6F|RSPO1_ENST00000401071.2_Missense_Mutation_p.C6F|RSPO1_ENST00000401069.1_Missense_Mutation_p.C6F	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	6					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCCACCACACACAGCCCAAG	0.642000													15	12					5.01169e-05	6.13175e-05	0.004990	1	0
DCSTAMP	81501	broad.mit.edu	37	8	105361495	105361495	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:105361495G>T	ENST00000297581.2	+	2	764	c.715G>T	c.(715-717)Ggt>Tgt	p.G239C	DCSTAMP_ENST00000517991.1_Missense_Mutation_p.G239C|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	239					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											GGGCCCTTGTGGTTGGAAGTA	0.502000													32	29					6.04164e-23	1.17884e-22	0.010818	1	0
BTBD11	121551	broad.mit.edu	37	12	107712990	107712990	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:107712990G>T	ENST00000280758.5	+	1	801	c.273G>T	c.(271-273)ctG>ctT	p.L91L	BTBD11_ENST00000420571.2_Silent_p.L91L|BTBD11_ENST00000490090.2_Silent_p.L91L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	91						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CGCGGCTGCTGCCGGACCTAG	0.706000													3	6					6.4e-05	7.73298e-05	0.004672	1	0
MAGI2	9863	broad.mit.edu	37	7	79082430	79082430	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:79082430C>G	ENST00000354212.4	-	1	460	c.207G>C	c.(205-207)gtG>gtC	p.V69V	MAGI2_ENST00000522391.1_Silent_p.V69V|MAGI2-AS3_ENST00000429408.1_RNA|MAGI2_ENST00000419488.1_Silent_p.V69V|MAGI2-AS3_ENST00000426835.1_RNA	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	69	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGGTCTCGTTCACCTCCAGCA	0.622000													18	48					0	0	0.007413	0	0
ZNF831	128611	broad.mit.edu	37	20	57769659	57769659	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:57769659C>A	ENST00000371030.2	+	1	3585	c.3585C>A	c.(3583-3585)ccC>ccA	p.P1195P		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1195						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCCCTCTGCCCGCGGAGCAGA	0.632000													11	25					0.00829132	0.00894152	0.008291	1	0
ST3GAL3	6487	broad.mit.edu	37	1	44280572	44280572	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:44280572G>A	ENST00000262915.3	+	4	398	c.221G>A	c.(220-222)cGg>cAg	p.R74Q	ST3GAL3_ENST00000330208.2_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000528371.1_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000372368.2_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000545417.1_Missense_Mutation_p.R74Q|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000372372.2_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000332628.6_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000533933.1_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000353126.3_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000531993.1_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000531816.1_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000372375.2_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000531451.1_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000372374.2_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000372362.2_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000372366.1_Missense_Mutation_p.R58Q|ST3GAL3_ENST00000372367.1_Missense_Mutation_p.R58Q|ST3GAL3_ENST00000372365.1_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000372377.4_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000372369.1_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000361746.4_Missense_Mutation_p.R74Q|ST3GAL3_ENST00000335430.6_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000361392.4_Missense_Mutation_p.R59Q|ST3GAL3_ENST00000361400.4_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000351035.3_Missense_Mutation_p.R43Q|ST3GAL3_ENST00000347631.2_Missense_Mutation_p.R74Q|ST3GAL3_ENST00000361812.4_Missense_Mutation_p.R74Q	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	59					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GAGTATGATCGGTTGGGCTTC	0.468000													7	109					0	0	0.003080	0	0
MIR873	100126316	broad.mit.edu	37	9	28888889	28888889	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:28888889C>A	ENST00000401120.1	-	0	64					NR_030618.1																						GTGGGTGTTCCCGGGAACTCA	0.428000													15	18					1.62849e-17	3.01008e-17	0.004007	1	0
KLKB1	3818	broad.mit.edu	37	4	187172752	187172752	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:187172752G>A	ENST00000264690.6	+	9	1167	c.980G>A	c.(979-981)cGc>cAc	p.R327H	KLKB1_ENST00000513864.1_Missense_Mutation_p.R327H	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	327	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity	p.R327H(2)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AAGATGATTCGCTGTCAGTTT	0.353000													7	41					0	0	0.003080	0	0
COL14A1	7373	broad.mit.edu	37	8	121239003	121239003	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:121239003G>T	ENST00000297848.3	+	16	2272	c.2002G>T	c.(2002-2004)Gag>Tag	p.E668*	COL14A1_ENST00000247781.3_Nonsense_Mutation_p.E573*|COL14A1_ENST00000309791.4_Nonsense_Mutation_p.E668*|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000537875.1_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	668	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GAAGACTGAGGAGGTGAGTTT	0.448000													6	28					0.00116845	0.00130426	0.001168	1	0
DLGAP3	58512	broad.mit.edu	37	1	35365842	35365842	+	Silent	SNP	G	G	T	rs149715442		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:35365842G>T	ENST00000373347.1	-	4	1408	c.1140C>A	c.(1138-1140)acC>acA	p.T380T	DLGAP3_ENST00000235180.4_Silent_p.T380T			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	380					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.T380T(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CCTTGCCACCGGTGGGGTAAC	0.612000													5	86					0.00116845	0.00130426	0.001168	1	0
OR2W3	343171	broad.mit.edu	37	1	248059293	248059293	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248059293C>A	ENST00000537741.1	+	3	662	c.405C>A	c.(403-405)atC>atA	p.I135I	OR2W3_ENST00000360358.3_Silent_p.I135I			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACATGGTGATCATGAACCCCA	0.617000													14	38					1.05317e-09	1.61211e-09	0.002450	1	0
ANK3	288	broad.mit.edu	37	10	61834532	61834532	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:61834532T>A	ENST00000280772.1	-	37	6298	c.6107A>T	c.(6106-6108)tAc>tTc	p.Y2036F	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2036					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATTTGTTAGGTAATCAATAAC	0.403000													15	60					0	0	0.004007	0	0
EGF	1950	broad.mit.edu	37	4	110897316	110897316	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:110897316G>T	ENST00000265171.5	+	13	2423	c.1978G>T	c.(1978-1980)Gat>Tat	p.D660Y	EGF_ENST00000509793.1_Missense_Mutation_p.D618Y|EGF_ENST00000503392.1_Missense_Mutation_p.D660Y	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	660					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTACTGGTGCGATGCCAAGCA	0.483000													9	42					0.000274275	0.000316429	0.004482	1	0
GRM1	2911	broad.mit.edu	37	6	146720058	146720058	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:146720058G>T	ENST00000392299.2	+	8	2353	c.1883G>T	c.(1882-1884)cGg>cTg	p.R628L	GRM1_ENST00000507907.1_Missense_Mutation_p.R628L|GRM1_ENST00000355289.4_Missense_Mutation_p.R628L|GRM1_ENST00000492807.2_Missense_Mutation_p.R628L|GRM1_ENST00000361719.2_Missense_Mutation_p.R628L|GRM1_ENST00000282753.1_Missense_Mutation_p.R628L			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	628					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R628Q(2)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCCTCCAGTCGGGAGCTCTGC	0.507000													36	110					1.22384e-17	2.267e-17	0.002836	1	0
SLIT3	6586	broad.mit.edu	37	5	168310291	168310291	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:168310291C>A	ENST00000519560.1	-	5	883	c.464G>T	c.(463-465)gGc>gTc	p.G155V	SLIT3_ENST00000404867.3_Missense_Mutation_p.G155V|SLIT3_ENST00000332966.8_Missense_Mutation_p.G155V	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	155					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding	p.G155D(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCGGTGATGCCGCGGAACGC	0.507000													11	21					6.40141e-05	7.73298e-05	0.010729	1	0
SLC17A4	10050	broad.mit.edu	37	6	25762211	25762211	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:25762211C>G	ENST00000377905.4	+	2	140	c.21C>G	c.(19-21)gtC>gtG	p.V7V	SLC17A4_ENST00000439485.2_Silent_p.V7V|SLC17A4_ENST00000397076.2_5'UTR	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	7					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GACCAGATGTCAAGGCTACAG	0.403000													7	21					0	0	0.004482	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004947	52004947	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:52004947C>A	ENST00000291707.3	-	1	96	c.41G>T	c.(40-42)gGg>gTg	p.G14V		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	14					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCCCACTCTCCCACAGagcag	0.572000													13	10					5.50884e-06	7.0564e-06	0.001368	1	0
SYNE2	23224	broad.mit.edu	37	14	64408654	64408654	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:64408654G>T	ENST00000358025.3	+	5	519	c.289G>T	c.(289-291)Gcc>Tcc	p.A97S	SYNE2_ENST00000341472.5_Missense_Mutation_p.A97S|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000356081.3_Missense_Mutation_p.A97S|SYNE2_ENST00000344113.4_Missense_Mutation_p.A97S|SYNE2_ENST00000554584.1_Missense_Mutation_p.A97S	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	97	Actin-binding.|CH 1.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATAGAACATGCCTTGACATT	0.328000													11	23					7.03913e-09	1.04583e-08	0.001368	1	0
MYO5C	55930	broad.mit.edu	37	15	52562007	52562007	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:52562007C>A	ENST00000261839.7	-	8	1044	c.883G>T	c.(883-885)Gag>Tag	p.E295*	MYO5C_ENST00000541028.1_Intron|MYO5C_ENST00000443683.2_Nonsense_Mutation_p.E238*	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	295	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TTCACACCCTCAATGACAGTA	0.388000													13	25					0.00316338	0.00347245	0.003163	1	0
NDUFV3	4731	broad.mit.edu	37	21	44323960	44323960	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:44323960G>T	ENST00000354250.2	+	3	907	c.838G>T	c.(838-840)Gaa>Taa	p.E280*	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	50					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AATAGATAAAGAAAGCCAAAA	0.418000													24	87					1.64293e-13	2.82986e-13	0.003330	1	0
PSKH2	85481	broad.mit.edu	37	8	87076652	87076652	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:87076652G>C	ENST00000276616.2	-	2	468	c.394C>G	c.(394-396)Caa>Gaa	p.Q132E	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	132	Protein kinase.		Q -> R (in dbSNP:rs16879427).				ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			ATGTAAACTTGATCCTCAGTC	0.542000													16	38					0	0	0.004007	0	0
MYOM2	9172	broad.mit.edu	37	8	2077162	2077162	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:2077162C>G	ENST00000262113.4	+	32	3883	c.3742C>G	c.(3742-3744)Cga>Gga	p.R1248G	MYOM2_ENST00000523438.1_Missense_Mutation_p.R673G	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1248					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGAAGGAATACGACTTCAGTG	0.453000													8	18					0	0	0.004482	0	0
SEPT9	10801	broad.mit.edu	37	17	75303255	75303255	+	Translation_Start_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:75303255A>T	ENST00000431235.2	+	0	357				SEPT9_ENST00000449803.2_De_novo_Start_InFrame|SEPT9_ENST00000591198.1_Intron|SEPT9_ENST00000427177.1_Missense_Mutation_p.R18W			Q9UHD8	SEPT9_HUMAN	septin 9						cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CCGGCTCCGGAGGCTTGGTGA	0.627000													42	84					0	0	0.013114	0	0
INHA	3623	broad.mit.edu	37	2	220439701	220439701	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:220439701C>G	ENST00000243786.2	+	2	734	c.554C>G	c.(553-555)gCt>gGt	p.A185G	INHA_ENST00000489456.1_3'UTR	NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	185					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCCACCTCTGCTCTCTCTCTG	0.687000													16	49					0	0	0.006122	0	0
GTDC1	79712	broad.mit.edu	37	2	144966327	144966327	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:144966327C>A	ENST00000409214.1	-	4	300	c.22G>T	c.(22-24)Gca>Tca	p.A8S	GTDC1_ENST00000241391.5_Missense_Mutation_p.A8S|GTDC1_ENST00000409298.1_Missense_Mutation_p.A8S|GTDC1_ENST00000392867.3_Missense_Mutation_p.A8S|GTDC1_ENST00000463875.2_Intron|GTDC1_ENST00000344850.4_Missense_Mutation_p.A8S|GTDC1_ENST00000392869.1_Missense_Mutation_p.A8S|GTDC1_ENST00000542155.1_Missense_Mutation_p.A8S	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	8					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		CCATAGAATGCTTCAATGATG	0.368000													9	27					1.76689e-08	2.57834e-08	0.006214	1	0
F13A1	2162	broad.mit.edu	37	6	6305730	6305730	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:6305730C>A	ENST00000264870.3	-	3	438	c.173G>T	c.(172-174)tGg>tTg	p.W58L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	58					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GTTAGTGTCCCATCTCTCCTT	0.403000													10	36					0.000442599	0.00050587	0.006214	1	0
BAI3	577	broad.mit.edu	37	6	70064178	70064178	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:70064178A>G	ENST00000370598.1	+	27	4334	c.3513A>G	c.(3511-3513)gcA>gcG	p.A1171A	BAI3_ENST00000238918.8_Silent_p.A377A|BAI3_ENST00000546190.1_Silent_p.A135A	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1171					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CCATCAATGCAGATTCTTCGA	0.388000													15	61					0	0	0.007413	0	0
STK35	140901	broad.mit.edu	37	20	2083825	2083825	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:2083825G>A	ENST00000381482.3	+	2	977	c.706G>A	c.(706-708)Gac>Aac	p.D236N	STK35_ENST00000246032.3_Missense_Mutation_p.D103N|STK35_ENST00000400064.3_Missense_Mutation_p.D64N			Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	236	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			large_intestine(2)|liver(2)|lung(6)|ovary(1)|prostate(2)	13						GATCCGCTGCGACGCCCCCGA	0.682000													5	8					0	0	0.000602	0	0
DDN	23109	broad.mit.edu	37	12	49391466	49391466	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:49391466C>A	ENST00000421952.2	-	2	1214	c.1193G>T	c.(1192-1194)aGc>aTc	p.S398I		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	398	Interaction with ACTN1.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						GAGTGTCTGGCTATGGCGGGG	0.612000													5	35					0.000157383	0.000184418	0.003080	1	0
SCUBE3	222663	broad.mit.edu	37	6	35210811	35210811	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:35210811G>T	ENST00000274938.7	+	15	1707	c.1707G>T	c.(1705-1707)ctG>ctT	p.L569L	SCUBE3_ENST00000394681.1_Silent_p.L585L	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	569					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						GCTGTGGGCTGCCCTGCCTCC	0.622000													10	56					6.40141e-05	7.73298e-05	0.010729	1	0
SLC1A6	6511	broad.mit.edu	37	19	15064949	15064949	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:15064949G>T	ENST00000430939.2	-	7	1299	c.1170C>A	c.(1168-1170)atC>atA	p.I390I	SLC1A6_ENST00000600144.1_Silent_p.I376I|SLC1A6_ENST00000221742.3_Silent_p.I454I			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	454					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity	p.I454I(1)		breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CCCCTCACCTGATGGTTGTGA	0.592000													12	33					4.3838e-07	5.98551e-07	0.001855	1	0
HHIPL1	84439	broad.mit.edu	37	14	100118597	100118597	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:100118597G>T	ENST00000330710.5	+	2	390	c.292G>T	c.(292-294)Gag>Tag	p.E98*	HHIPL1_ENST00000357223.2_Nonsense_Mutation_p.E98*	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	98					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				CTATGACGCCGAGGACCCATT	0.592000													12	35					3.27435e-08	4.74188e-08	0.002450	1	0
ASTN1	460	broad.mit.edu	37	1	177133679	177133679	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:177133679A>T	ENST00000367654.2	-	1	147	c.134T>A	c.(133-135)cTg>cAg	p.L45Q	ASTN1_ENST00000424564.2_Missense_Mutation_p.L45Q|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000361833.2_Missense_Mutation_p.L45Q|ASTN1_ENST00000367657.3_Missense_Mutation_p.L45Q			O14525	ASTN1_HUMAN	astrotactin 1	45					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CAGGAAGGGCAGTGCCGACAC	0.662000													8	26					0	0	0.008291	0	0
GZMH	2999	broad.mit.edu	37	14	25077588	25077588	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:25077588G>T	ENST00000216338.4	-	2	130	c.86C>A	c.(85-87)cCc>cAc	p.P29H	GZMH_ENST00000557220.2_Missense_Mutation_p.P29H|GZMH_ENST00000382548.4_Missense_Mutation_p.P29H|RP11-104E19.1_ENST00000557736.1_RNA|RP11-104E19.1_ENST00000555300.1_RNA	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	29	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		GCGGGAGTGGGGCTTGGCCTC	0.542000													12	100					4.3838e-07	5.98551e-07	0.001855	1	0
CLASP1	23332	broad.mit.edu	37	2	122122783	122122783	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:122122783T>C	ENST00000263710.4	-	36	4353	c.3964A>G	c.(3964-3966)Aag>Gag	p.K1322E	CLASP1_ENST00000541377.1_Missense_Mutation_p.K1261E|CLASP1_ENST00000541859.1_Missense_Mutation_p.K1039E|CLASP1_ENST00000545861.1_Missense_Mutation_p.K1029E|CLASP1_ENST00000409078.3_Missense_Mutation_p.K1255E|CLASP1_ENST00000397587.3_Missense_Mutation_p.K1262E|CLASP1_ENST00000455322.2_Missense_Mutation_p.K1278E	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1322	Interaction with CLIP2 (By similarity).|Interaction with PHLDB2 and RSN.|Localization to kinetochores.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					AGGGCTCCCTTCCGTTCCTCC	0.567000													4	13					0	0	0.009096	0	0
DAPK2	23604	broad.mit.edu	37	15	64204383	64204383	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:64204383T>A	ENST00000261891.3	-	9	877	c.872A>T	c.(871-873)cAg>cTg	p.Q291L	DAPK2_ENST00000457488.1_Missense_Mutation_p.Q291L			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	291	Calmodulin-binding.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		CATGGCTTGCTGGTTGTCCAC	0.622000													4	10					0	0	0.009096	0	0
ZNF467	168544	broad.mit.edu	37	7	149462026	149462026	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:149462026C>G	ENST00000302017.3	-	5	1978	c.1565G>C	c.(1564-1566)cGc>cCc	p.R522P	ZNF467_ENST00000484747.1_Intron	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGAAGCTGCGGGCGCAGAC	0.701000													5	52					0	0	0.000602	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489935	20489935	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:20489935C>A	ENST00000573854.1	+	10	1331	c.1217C>A	c.(1216-1218)aCa>aAa	p.T406K	ACSM2A_ENST00000536134.1_Missense_Mutation_p.T178K|ACSM2A_ENST00000575690.1_Missense_Mutation_p.T406K|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000417235.2_Missense_Mutation_p.T327K|ACSM2A_ENST00000396104.2_Missense_Mutation_p.T406K|ACSM2A_ENST00000219054.6_Missense_Mutation_p.T406K	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	406					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CCCCCCGGCACAGAAGGAGAC	0.512000													13	48					2.62699e-14	4.63158e-14	0.003163	1	0
OR51A4	401666	broad.mit.edu	37	11	4968029	4968029	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:4968029G>C	ENST00000380373.2	-	1	327	c.302C>G	c.(301-303)gCc>gGc	p.A101G	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAATTCCTGGGCAAAGCAGGC	0.443000													11	92					0	0	0.001855	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140594	3140594	+	Translation_Start_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:3140594C>A	ENST00000575108.1	-	0	547				ZSCAN10_ENST00000538082.2_Missense_Mutation_p.G144W|ZSCAN10_ENST00000572548.1_3'UTR|ZSCAN10_ENST00000252463.2_Missense_Mutation_p.G226W			Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10						negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CAGGCAGCCCCTTTGGGCTCT	0.612000													8	52					3.09899e-07	4.27198e-07	0.004482	1	0
ATRNL1	26033	broad.mit.edu	37	10	117027883	117027883	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:117027883G>T	ENST00000355044.3	+	13	2188	c.2062G>T	c.(2062-2064)Gac>Tac	p.D688Y		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	688	PSI 2.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATGGTGTGATGACAAGAAATG	0.408000													9	40					0.000274275	0.000316429	0.004482	1	0
DUSP27	92235	broad.mit.edu	37	1	167097512	167097512	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:167097512C>T	ENST00000361200.2	+	6	3310	c.3144C>T	c.(3142-3144)tcC>tcT	p.S1048S	DUSP27_ENST00000271385.5_Silent_p.S1048S|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Silent_p.S1048S			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1048					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCCCAGAGTCCTCAGAAAGGG	0.562000													6	25					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179468686	179468686	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179468686T>A	ENST00000589042.1	-	282	54952	c.54728A>T	c.(54727-54729)cAg>cTg	p.Q18243L	TTN_ENST00000342175.6_Missense_Mutation_p.Q9370L|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.Q9178L|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q9303L|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.Q16602L|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Q15675L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16602	Fibronectin type-III 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTCTGAACTGGTATTTAAC	0.458000													44	258					0	0	0.009718	0	0
ABCA2	20	broad.mit.edu	37	9	139911094	139911094	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:139911094C>A	ENST00000265662.5	-	20	3002	c.2855G>T	c.(2854-2856)tGg>tTg	p.W952L	ABCA2_ENST00000341511.6_Missense_Mutation_p.W952L|ABCA2_ENST00000371605.3_Missense_Mutation_p.W951L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	951					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGTGCGTGCCCACGGCCAGCT	0.672000													8	23					0.000157383	0.000184418	0.003080	1	0
LGR6	59352	broad.mit.edu	37	1	202270015	202270015	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:202270015A>T	ENST00000367278.3	+	8	913	c.824A>T	c.(823-825)aAg>aTg	p.K275M	LGR6_ENST00000439764.2_Missense_Mutation_p.K136M|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Missense_Mutation_p.K223M	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	275						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						ATCCCAGAAAAGGCCTTCATG	0.502000													18	77					0	0	0.006122	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679016	37679016	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:37679016G>T	ENST00000379800.3	-	1	787	c.378C>A	c.(376-378)taC>taA	p.Y126*		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	126	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TTGTATGCACGTATTCAATTC	0.403000													8	64					3.09899e-07	4.27198e-07	0.004482	1	0
FKBP9L	360132	broad.mit.edu	37	7	55755566	55755566	+	RNA	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:55755566C>G	ENST00000455909.1	-	0	440					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						CCATCCCCAACACAACTTGCC	0.512000													21	84					0	0	0.002780	0	0
CLCN3	1182	broad.mit.edu	37	4	170613336	170613336	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:170613336C>G	ENST00000513761.1	+	7	1360	c.801C>G	c.(799-801)atC>atG	p.I267M	CLCN3_ENST00000504131.2_Missense_Mutation_p.I250M|CLCN3_ENST00000360642.3_Missense_Mutation_p.I267M|CLCN3_ENST00000347613.4_Missense_Mutation_p.I267M	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	267					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		TTAAAACCATCACATTAGTCC	0.388000													19	114					0	0	0.007413	0	0
GOLGA3	2802	broad.mit.edu	37	12	133354352	133354352	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:133354352G>A	ENST00000204726.3	-	19	4180	c.3622C>T	c.(3622-3624)Cac>Tac	p.H1208Y	GOLGA3_ENST00000456883.2_Missense_Mutation_p.H1208Y|GOLGA3_ENST00000450791.2_Missense_Mutation_p.H1208Y	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1208					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCCTTGAAGTGGCGGCGGTTA	0.617000													11	11					0	0	0.008291	0	0
GFRA1	2674	broad.mit.edu	37	10	118030335	118030335	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:118030335C>A	ENST00000439649.3	-	3	700	c.334_splice	c.e3+1	p.Q111_splice	GFRA1_ENST00000369236.1_Splice_Site_p.Q111_splice|GFRA1_ENST00000355422.6_Splice_Site_p.Q111_splice	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	111					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CACGCGTACCCTGCAGGCTCT	0.612000													6	42					0.00198382	0.00219304	0.001984	1	0
TAS2R16	50833	broad.mit.edu	37	7	122634999	122634999	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:122634999G>T	ENST00000249284.2	-	1	755	c.690C>A	c.(688-690)gcC>gcA	p.A230A		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	230					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding	p.A230A(2)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TAAATAAGACGGCAAGGGACC	0.433000													12	112					0.000978159	0.00110043	0.010729	1	0
IGHV2-70	28454	broad.mit.edu	37	14	107178997	107178997	+	RNA	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:107178997C>G	ENST00000390634.2	-	0	255																											TCCCTGGGGGCTGACGGATCC	0.542000													6	67					0	0	0.001984	0	0
OR2G3	81469	broad.mit.edu	37	1	247769675	247769675	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247769675G>C	ENST00000320002.2	+	1	820	c.788G>C	c.(787-789)aGt>aCt	p.S263T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTGCAACCTAGTGACAGCTAT	0.463000													9	47					0	0	0.004482	0	0
IL22RA2	116379	broad.mit.edu	37	6	137468906	137468906	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:137468906A>T	ENST00000296980.2	-	6	895	c.595T>A	c.(595-597)Tat>Aat	p.Y199N	IL22RA2_ENST00000339602.3_Intron|IL22RA2_ENST00000349184.4_Missense_Mutation_p.Y167N	NM_052962.2	NP_443194.1	Q969J5	I22R2_HUMAN	interleukin 22 receptor, alpha 2	199	Fibronectin type-III 3.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity			endometrium(1)|large_intestine(1)|lung(3)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		AGTAGTTCATAGTAATCTTCT	0.274000													10	55					0	0	0.006214	0	0
OR6A2	8590	broad.mit.edu	37	11	6816649	6816649	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6816649G>T	ENST00000332601.3	-	1	479	c.291C>A	c.(289-291)atC>atA	p.I97I		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTCAAAGGAGATTAGCTGTC	0.468000													15	19					7.93312e-07	1.07125e-06	0.002450	1	0
DPYD	1806	broad.mit.edu	37	1	97564188	97564188	+	Splice_Site	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:97564188T>G	ENST00000370192.3	-	21	2723	c.2622_splice	c.e21-1	p.K875_splice	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	875					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTTGGCAGTTTCTAAAAGGAA	0.328000													3	5					0	0	0.004672	0	0
SLC25A28	81894	broad.mit.edu	37	10	101371021	101371021	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:101371021C>A	ENST00000370495.4	-	4	708	c.680G>T	c.(679-681)aGc>aTc	p.S227I	SLC25A28_ENST00000496035.1_5'UTR	NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	227					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		GGTGGTGTAGCTGCGGTAAAA	0.532000													16	36					2.23348e-06	2.95335e-06	0.004007	1	0
PTDSS1	9791	broad.mit.edu	37	8	97307406	97307406	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:97307406G>T	ENST00000517309.1	+	5	848	c.522G>T	c.(520-522)tgG>tgT	p.W174C	PTDSS1_ENST00000455950.2_Missense_Mutation_p.W28C|PTDSS1_ENST00000518776.1_3'UTR	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	174					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GACATTTCTGGGGCTGGGCCA	0.468000													5	38					0.000602214	0.000681505	0.000602	1	0
LOC645166	645166	broad.mit.edu	37	1	148932898	148932898	+	RNA	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:148932898C>G	ENST00000539543.1	+	0	154					NR_027355.1																						GCTCAGTCTGCGGCCAAGACT	0.617000													6	121					0	0	0.003080	0	0
ASCC3	10973	broad.mit.edu	37	6	101073156	101073156	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:101073156C>A	ENST00000369162.2	-	30	5041	c.4697G>T	c.(4696-4698)cGt>cTt	p.R1566L		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1566	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		ACGAGTTTGACGTCTTGATGA	0.398000													11	24					2.80697e-09	4.24753e-09	0.010729	1	0
HNRNPR	10236	broad.mit.edu	37	1	23637164	23637164	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:23637164C>A	ENST00000478691.1	-	10	1662	c.1391G>T	c.(1390-1392)cGg>cTg	p.R464L	HNRNPR_ENST00000374612.1_Missense_Mutation_p.R562L|HNRNPR_ENST00000374616.3_Missense_Mutation_p.R565L|HNRNPR_ENST00000302271.6_Missense_Mutation_p.R562L|HNRNPR_ENST00000476660.1_5'UTR|HNRNPR_ENST00000427764.2_Missense_Mutation_p.R524L|HNRNPR_ENST00000606561.1_Missense_Mutation_p.R423L|HNRNPR_ENST00000426846.2_Missense_Mutation_p.R402L	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	562	3 X 11 AA approximate repeats of D-D-Y-Y- G-Y-D-Y-H-D-Y.|RNA-binding RGG-box.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding	p.R562Q(2)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		ACGATTGCCCCGAGATCCACG	0.587000													14	66					0.00244969	0.00270458	0.002450	1	0
ZNF716	441234	broad.mit.edu	37	7	57528796	57528796	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:57528796A>T	ENST00000420713.1	+	4	741	c.629A>T	c.(628-630)gAg>gTg	p.E210V		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						CATACTAGGGAGAAGTCTTAC	0.353000													10	11					0	0	0.006214	0	0
DAB2	1601	broad.mit.edu	37	5	39376927	39376927	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:39376927C>A	ENST00000320816.6	-	12	2429	c.1962G>T	c.(1960-1962)atG>atT	p.M654I	DAB2_ENST00000509337.1_Missense_Mutation_p.M633I|DAB2_ENST00000339788.6_Missense_Mutation_p.M436I|DAB2_ENST00000545653.1_Missense_Mutation_p.M633I	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	654	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			AATCCTTAAACATTTCTTTCA	0.527000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	81					4.36969e-10	6.76712e-10	0.001855	1	0
WDR47	22911	broad.mit.edu	37	1	109554149	109554149	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:109554149T>C	ENST00000357672.3	-	4	810	c.435A>G	c.(433-435)gcA>gcG	p.A145A	WDR47_ENST00000369962.3_Silent_p.A173A|WDR47_ENST00000369965.4_Silent_p.A173A|WDR47_ENST00000400794.3_Silent_p.A180A|WDR47_ENST00000361054.3_Silent_p.A145A			O94967	WDR47_HUMAN	WD repeat domain 47	173										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GGATGAATTCTGCAACCATGA	0.438000													23	127					0	0	0.003330	0	0
TMTC1	83857	broad.mit.edu	37	12	29911707	29911707	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:29911707C>A	ENST00000256062.5	-	3	633	c.160G>T	c.(160-162)Gct>Tct	p.A54S	TMTC1_ENST00000551659.1_Missense_Mutation_p.A162S|TMTC1_ENST00000552618.1_Missense_Mutation_p.A162S|TMTC1_ENST00000381224.2_Missense_Mutation_p.A54S|TMTC1_ENST00000539277.1_Missense_Mutation_p.A162S	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	162						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					ACGATCCCAGCCACCTTGGAA	0.378000													6	21					3.59834e-05	4.44363e-05	0.001168	1	0
LPO	4025	broad.mit.edu	37	17	56329618	56329618	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:56329618A>G	ENST00000262290.4	+	8	1172	c.856A>G	c.(856-858)Act>Gct	p.T286A	LPO_ENST00000543544.1_Missense_Mutation_p.T227A|LPO_ENST00000582328.1_Missense_Mutation_p.T203A|LPO_ENST00000421678.2_Missense_Mutation_p.T203A	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	286					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						CGTCTGCCCCACTCCACCCTA	0.597000													22	37					0	0	0.012319	0	0
PKHD1	5314	broad.mit.edu	37	6	51524559	51524559	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:51524559T>A	ENST00000371117.3	-	61	10640	c.10365A>T	c.(10363-10365)tcA>tcT	p.S3455S		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3455					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AAGTAGACACTGACCCAGAAG	0.403000													6	42					0	0	0.001168	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122334710	122334710	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:122334710T>A	ENST00000398250.1	+	6	865	c.513T>A	c.(511-513)agT>agA	p.S171R	PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.S161R|PPAPDC1A_ENST00000439221.1_Missense_Mutation_p.S108R|PPAPDC1A_ENST00000496437.1_3'UTR|PPAPDC1A_ENST00000398248.1_Intron|PPAPDC1A_ENST00000541332.1_Missense_Mutation_p.S171R	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	171					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TCACCGAGAGTGGGCGGGGAA	0.582000													10	62					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179500696	179500696	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179500696C>A	ENST00000589042.1	-	226	41826	c.41602G>T	c.(41602-41604)Gta>Tta	p.V13868L	TTN_ENST00000342175.6_Missense_Mutation_p.V4995L|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V4803L|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V4928L|TTN_ENST00000591111.1_Missense_Mutation_p.V12227L|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V11300L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12227							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACCTACTACTTTTACGCAA	0.423000													17	169					3.41278e-10	5.3284e-10	0.004990	1	0
PANK3	79646	broad.mit.edu	37	5	167995915	167995915	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:167995915T>C	ENST00000239231.6	-	2	433	c.117A>G	c.(115-117)caA>caG	p.Q39Q		NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	39					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CAACTTCTTCTTGCTCTTCCT	0.423000													16	28					0	0	0.003163	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063718	247063718	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247063718C>A	ENST00000366508.1	-	9	1412	c.1276G>T	c.(1276-1278)Gga>Tga	p.G426*	AHCTF1_ENST00000326225.3_Nonsense_Mutation_p.G400*|AHCTF1_ENST00000391829.2_Nonsense_Mutation_p.G391*			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	391	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTTCCCTGTCCATATATATTC	0.348000													8	39					5.4927e-09	8.18194e-09	0.004482	1	0
GRM1	2911	broad.mit.edu	37	6	146351134	146351134	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:146351134G>T	ENST00000392299.2	+	2	951	c.481G>T	c.(481-483)Ggt>Tgt	p.G161C	GRM1_ENST00000507907.1_Missense_Mutation_p.G161C|GRM1_ENST00000355289.4_Missense_Mutation_p.G161C|GRM1_ENST00000492807.2_Missense_Mutation_p.G161C|GRM1_ENST00000361719.2_Missense_Mutation_p.G161C|GRM1_ENST00000282753.1_Missense_Mutation_p.G161C			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	161					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGGAGTGATCGGTCCCGGCTC	0.572000													19	30					1.01871e-10	1.61547e-10	0.008871	1	0
NCAPD3	23310	broad.mit.edu	37	11	134026925	134026925	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:134026925T>C	ENST00000534548.2	-	32	4304	c.4240A>G	c.(4240-4242)Agc>Ggc	p.S1414G		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1414					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TCGGGGGTGCTGATGGCCCGC	0.507000													14	89					0	0	0.004007	0	0
SEZ6L	23544	broad.mit.edu	37	22	26701995	26701995	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:26701995C>A	ENST00000529632.2	+	6	1595	c.1399C>A	c.(1399-1401)Cca>Aca	p.P467T	SEZ6L_ENST00000248933.6_Missense_Mutation_p.P467T|SEZ6L_ENST00000403121.1_Missense_Mutation_p.P240T|SEZ6L_ENST00000343706.4_Missense_Mutation_p.P467T|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P467T|SEZ6L_ENST00000402979.1_Missense_Mutation_p.P240T|SEZ6L_ENST00000360929.3_Missense_Mutation_p.P467T	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	467	CUB 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CGTCCTCTCCCCAAGTTACCC	0.572000													7	28					0.000157383	0.000184418	0.003080	1	0
FAM120C	54954	broad.mit.edu	37	X	54161386	54161386	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:54161386G>A	ENST00000375180.2	-	7	1550	c.1494C>T	c.(1492-1494)tcC>tcT	p.S498S	FAM120C_ENST00000328235.4_Silent_p.S498S	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	498										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AAGAGTCATAGGAGACAGCCC	0.512000													4	11					0	0	0.009096	0	0
EPHB1	2047	broad.mit.edu	37	3	134968220	134968220	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:134968220G>T	ENST00000398015.3	+	15	3103	c.2733G>T	c.(2731-2733)acG>acT	p.T911T	EPHB1_ENST00000493838.1_Silent_p.T472T	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	911	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CAGACTTCACGGCCTTTACCA	0.602000													26	17					1.85244e-09	2.8205e-09	0.003330	1	0
KPNA6	23633	broad.mit.edu	37	1	32623006	32623006	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:32623006G>A	ENST00000373625.3	+	4	384	c.291G>A	c.(289-291)caG>caA	p.Q97Q	KPNA6_ENST00000545542.1_Silent_p.Q102Q|KPNA6_ENST00000537234.1_Silent_p.Q94Q|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	97					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGACCTGCAGTTAGCAACCA	0.428000													9	27					0	0	0.006214	0	0
CDK11A	728642	broad.mit.edu	37	1	1654058	1654058	+	Translation_Start_Site	SNP	C	C	T	rs61777495	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:1654058C>T	ENST00000356200.3	-	0	212				CDK11A_ENST00000357760.2_Intron|CDK11A_ENST00000358779.5_Intron|CDK11A_ENST00000378635.3_Intron|CDK11A_ENST00000404249.3_Intron|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378638.2_De_novo_Start_OutOfFrame|CDK11A_ENST00000378633.1_Intron					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						AAGAACTTCACCGAAGAAGCG	0.338000													4	23					0	0	0.001168	0	0
COL17A1	1308	broad.mit.edu	37	10	105798268	105798268	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:105798268A>T	ENST00000353479.5	-	45	3256	c.2966T>A	c.(2965-2967)aTg>aAg	p.M989K	COL17A1_ENST00000369733.3_Missense_Mutation_p.M944K	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	989	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGACACGTACATGGTACTTGA	0.592000													25	68					0	0	0.003954	0	0
HCN1	348980	broad.mit.edu	37	5	45262699	45262699	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:45262699G>C	ENST00000303230.4	-	8	2054	c.1997C>G	c.(1996-1998)cCg>cGg	p.P666R		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	666						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGTGTACACCGGTGGAGATTG	0.577000													9	91					0	0	0.006214	0	0
CCDC141	285025	broad.mit.edu	37	2	179714841	179714841	+	Nonsense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179714841T>A	ENST00000420890.2	-	21	3409	c.3292A>T	c.(3292-3294)Aaa>Taa	p.K1098*	CCDC141_ENST00000295723.5_Nonsense_Mutation_p.K523*	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	523							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGAACCTCTTTGTGTTTTGTC	0.358000													12	32					0	0	0.001855	0	0
MORC3	23515	broad.mit.edu	37	21	37741461	37741461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:37741461G>T	ENST00000400485.1	+	15	1871	c.1795G>T	c.(1795-1797)Gaa>Taa	p.E599*	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	599					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						CATGAAATCAGAACAGAGTCA	0.433000													24	40					2.21704e-12	3.71813e-12	0.002780	1	0
LGALS9B	284194	broad.mit.edu	37	17	20354854	20354854	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:20354854C>A	ENST00000423676.3	-	10	927	c.864G>T	c.(862-864)tgG>tgT	p.W288C	LGALS9B_ENST00000324290.5_Missense_Mutation_p.W287C			Q3B8N2	LEG9B_HUMAN	lectin, galactoside-binding, soluble, 9B	288	Beta-galactoside binding 2 (By similarity).|Galectin 2.						sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	10						CCTCAGACCCCCAAGAGTTGT	0.577000													11	32					7.93312e-07	1.07125e-06	0.002450	1	0
EXOC4	60412	broad.mit.edu	37	7	133622741	133622741	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:133622741G>A	ENST00000253861.4	+	14	2154	c.2125G>A	c.(2125-2127)Gcc>Acc	p.A709T	EXOC4_ENST00000539845.1_Missense_Mutation_p.A608T|EXOC4_ENST00000545148.1_Missense_Mutation_p.A319T|EXOC4_ENST00000541309.1_5'UTR	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	709					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				TGACCTCAAAGCCTTGGCCAA	0.463000													35	65					0	0	0.003755	0	0
TNR	7143	broad.mit.edu	37	1	175331847	175331847	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:175331847C>T	ENST00000367674.1	-	14	3514	c.2806G>A	c.(2806-2808)Gtg>Atg	p.V936M	TNR_ENST00000263525.2_Missense_Mutation_p.V936M	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	936	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTGCCCCGCACGCTGTTGAGG	0.552000													19	62					0	0	0.006122	0	0
GABRG2	2566	broad.mit.edu	37	5	161576309	161576309	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:161576309A>G	ENST00000356592.3	+	8	1578	c.1118A>G	c.(1117-1119)aAg>aGg	p.K373R	GABRG2_ENST00000393933.4_Missense_Mutation_p.K278R|GABRG2_ENST00000414552.2_Missense_Mutation_p.K413R|GABRG2_ENST00000361925.4_Missense_Mutation_p.K373R	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	373					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GATAAAAAGAAGAAAAACCCT	0.388000													6	22					0	0	0.001984	0	0
KLHL11	55175	broad.mit.edu	37	17	40010890	40010890	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:40010890T>C	ENST00000319121.3	-	2	1289	c.1229A>G	c.(1228-1230)tAt>tGt	p.Y410C		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	410						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				TCCAGCAACATACACGTAGGA	0.408000													22	100					0	0	0.002299	0	0
LTC4S	4056	broad.mit.edu	37	5	179221117	179221117	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:179221117C>A	ENST00000292596.10	+	1	131	c.36C>A	c.(34-36)acC>acA	p.T12T	LTC4S_ENST00000401985.3_Silent_p.T12T|MAML1_ENST00000503050.1_3'UTR	NM_145867.1	NP_665874.1	Q16873	LTC4S_HUMAN	leukotriene C4 synthase	12					hormone biosynthetic process|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|prostanoid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear outer membrane	enzyme activator activity|glutathione peroxidase activity|leukotriene-C4 synthase activity|lipid binding			haematopoietic_and_lymphoid_tissue(1)	1	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Glutathione(DB00143)	CTGCTGTCACCCTCCTGGGAG	0.622000													11	29					9.70103e-10	1.49026e-09	0.008291	1	0
SALL1	6299	broad.mit.edu	37	16	51171227	51171227	+	Missense_Mutation	SNP	G	G	T	rs145423593		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:51171227G>T	ENST00000440970.1	-	3	3911	c.3480C>A	c.(3478-3480)aaC>aaA	p.N1160K	SALL1_ENST00000541611.1_Missense_Mutation_p.N80K|SALL1_ENST00000566102.1_3'UTR|SALL1_ENST00000251020.4_Missense_Mutation_p.N1257K	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1257					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.N1257N(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGATGCCACCGTTCTGAATGA	0.577000													11	27					3.86212e-05	4.72862e-05	0.008291	1	0
ZBTB21	49854	broad.mit.edu	37	21	43412040	43412040	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:43412040T>C	ENST00000310826.5	-	3	2348	c.2165A>G	c.(2164-2166)tAc>tGc	p.Y722C	ZBTB21_ENST00000398499.1_Missense_Mutation_p.Y722C|ZBTB21_ENST00000398505.3_Intron|ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398511.3_Missense_Mutation_p.Y722C	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GCGGCACTGGTAAACCTCCTT	0.502000													58	202					0	0	0.003610	0	0
TRAV27	28655	broad.mit.edu	37	14	22616550	22616550	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22616550C>A	ENST00000390457.2	+	0	388																											TCACTGCAGCCCAGCCTGGTG	0.552000													7	49					0.00198382	0.00219304	0.001984	1	0
OR51A4	401666	broad.mit.edu	37	11	4968004	4968004	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:4968004G>A	ENST00000380373.2	-	1	352	c.327C>T	c.(325-327)ttC>ttT	p.F109F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCAGTACTGAGAATCCATGAA	0.448000													13	125					0	0	0.004007	0	0
CDH10	1008	broad.mit.edu	37	5	24535843	24535843	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:24535843C>G	ENST00000264463.4	-	4	1122	c.615G>C	c.(613-615)ggG>ggC	p.G205G		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	205	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AATAGGGCTGCCCTTGAAGTA	0.443000										HNSCC(23;0.051)			14	64					0	0	0.002450	0	0
GSTA1	2938	broad.mit.edu	37	6	52657700	52657700	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:52657700A>C	ENST00000334575.5	-	6	655	c.500T>G	c.(499-501)gTc>gGc	p.V167G	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	167	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AAGCTCCTCGACGTAGTAGAG	0.532000													5	130					0	0	0.006214	0	0
BMP2K	55589	broad.mit.edu	37	4	79831904	79831904	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:79831904A>T	ENST00000335016.5	+	16	2369	c.2203A>T	c.(2203-2205)Aag>Tag	p.K735*	PAQR3_ENST00000295462.3_Intron	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	735						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						TCAAGTGCAAAAGGGGAATGA	0.438000													7	34					0	0	0.003080	0	0
FCRL3	115352	broad.mit.edu	37	1	157665394	157665394	+	Missense_Mutation	SNP	G	G	T	rs112099510		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:157665394G>T	ENST00000368184.3	-	8	1427	c.1136C>A	c.(1135-1137)cCg>cAg	p.P379Q	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.P379Q|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	379						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GTGAGATACCGGAACTGAAGG	0.572000													12	45					2.80697e-09	4.24753e-09	0.010729	1	0
CACNA1G	8913	broad.mit.edu	37	17	48683512	48683512	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:48683512T>C	ENST00000416767.4	+	23	4578	c.4550T>C	c.(4549-4551)cTg>cCg	p.L1517P	CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000515411.1_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000359106.5_Intron|CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000513689.2_Intron|CACNA1G_ENST00000510115.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000352832.5_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000507510.2_Intron|CACNA1G_ENST00000354983.4_Intron|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000507336.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000515765.1_Intron|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000360761.4_Intron			O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	0					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TCACACCCTCTGCTGTCTAAC	0.577000													8	25					0	0	0.003080	0	0
OR2L8	391190	broad.mit.edu	37	1	248112525	248112525	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248112525C>T	ENST00000357191.3	+	1	366	c.366C>T	c.(364-366)taC>taT	p.Y122Y	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATGATCGTTACATTGCTATTT	0.448000													32	152					0	0	0.008361	0	0
C7orf26	79034	broad.mit.edu	37	7	6639514	6639514	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:6639514A>T	ENST00000344417.5	+	4	902	c.635A>T	c.(634-636)gAg>gTg	p.E212V	C7orf26_ENST00000359073.5_Missense_Mutation_p.E193V|C7orf26_ENST00000472693.1_3'UTR	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	212										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		TGGATTTTTGAGGACCCAAGG	0.468000													72	104					0	0	0.003610	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961331	73961331	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:73961331C>T	ENST00000373468.1	-	3	3712	c.3061G>A	c.(3061-3063)Gat>Aat	p.D1021N	KIAA2022_ENST00000055682.5_Missense_Mutation_p.D1021N			Q5QGS0	K2022_HUMAN	KIAA2022	1021					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCAGTGATATCATCATCGCCA	0.478000													18	49					0	0	0.007413	0	0
TRAV12-1	28674	broad.mit.edu	37	14	22309871	22309871	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22309871G>T	ENST00000390433.1	+	0	255																											TTACAGCACAGCTCAATAGAG	0.483000													15	94					1.05317e-09	1.61211e-09	0.002450	1	0
BTBD11	121551	broad.mit.edu	37	12	108043084	108043084	+	Nonstop_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:108043084G>T	ENST00000490090.2	+	15	3024	c.3024G>T	c.(3022-3024)taG>taT	p.*1008Y	BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000494235.2_Intron|BTBD11_ENST00000280758.5_Intron|BTBD11_ENST00000357167.4_Intron			A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	0						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGCTATCATAGGTCCCTTGGG	0.483000													24	23					6.44725e-10	9.94868e-10	0.002299	1	0
OR6S1	341799	broad.mit.edu	37	14	21109704	21109704	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:21109704C>A	ENST00000320704.3	-	1	146	c.147G>T	c.(145-147)ggG>ggT	p.G49G		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CCCTTACCACCCCCACAATCA	0.463000													31	39					5.60225e-13	9.53492e-13	0.009535	1	0
FCN2	2220	broad.mit.edu	37	9	137779182	137779182	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:137779182C>G	ENST00000350339.2	+	7	763	c.749C>G	c.(748-750)gCa>gGa	p.A250G	FCN2_ENST00000291744.6_Missense_Mutation_p.A288G	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	288	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GGCAGCTTTGCAAATGGCATC	0.517000													11	30					0	0	0.008291	0	0
C14orf180	400258	broad.mit.edu	37	14	105054645	105054645	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:105054645G>T	ENST00000557649.1	+	4	612	c.277_splice	c.e4+1	p.R92_splice	C14orf180_ENST00000331952.2_Splice_Site_p.R92_splice|C14orf180_ENST00000410013.1_Splice_Site_p.R92_splice			Q8N912	CN180_HUMAN	chromosome 14 open reading frame 180	92						integral to membrane							Melanoma(154;0.226)	all cancers(16;0.00405)|OV - Ovarian serous cystadenocarcinoma(23;0.0319)|Epithelial(46;0.0784)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.127)		CCACTGTCAGGGGTGAGTTCT	0.662000													29	66					5.77227e-19	1.08562e-18	0.008361	1	0
MTOR	2475	broad.mit.edu	37	1	11194472	11194472	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:11194472C>A	ENST00000361445.4	-	37	5258	c.5182G>T	c.(5182-5184)Gcc>Tcc	p.A1728S	MTOR_ENST00000495435.1_5'UTR	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1728	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GCATGCTGGGCCTGTTGCTGC	0.562000													48	34					6.3008e-33	1.25797e-32	0.003610	1	0
WIPI1	55062	broad.mit.edu	37	17	66440643	66440643	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:66440643T>G	ENST00000262139.5	-	4	420	c.421A>C	c.(421-423)Aac>Cac	p.N141H	WIPI1_ENST00000546360.1_Missense_Mutation_p.N59H|WIPI1_ENST00000589459.1_5'UTR	NM_017983.5	NP_060453.3	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting 1	141					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	18						CCTGTTGGGTTTGCAGGAATA	0.423000													31	44					0	0	0.008361	0	0
ANKS1B	56899	broad.mit.edu	37	12	100169423	100169423	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:100169423C>A	ENST00000547776.2	-	7	863	c.864G>T	c.(862-864)gtG>gtT	p.V288V	ANKS1B_ENST00000329257.7_Silent_p.V288V|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	288						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TAGATCTTCCCACGCCTTCTA	0.348000													9	22					0.000673444	0.000759613	0.008291	1	0
NPY4R	5540	broad.mit.edu	37	10	47087349	47087349	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:47087349C>A	ENST00000374312.1	+	3	985	c.566C>A	c.(565-567)tCc>tAc	p.S189Y	NPY4R_ENST00000395716.1_Missense_Mutation_p.S189Y	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		AAGAACCACTCCAAGGCTCTG	0.582000													15	118					1.05317e-09	1.61211e-09	0.002450	1	0
TTN	7273	broad.mit.edu	37	2	179439522	179439522	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179439522G>C	ENST00000589042.1	-	326	71561	c.71337C>G	c.(71335-71337)acC>acG	p.T23779T	TTN_ENST00000342175.6_Silent_p.T14906T|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Silent_p.T14714T|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Silent_p.T14839T|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Silent_p.T22138T|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.T21211T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22138	Fibronectin type-III 73.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATAACGGTGGTTGCTAACT	0.468000													11	83					0	0	0.008291	0	0
CCDC126	90693	broad.mit.edu	37	7	23651099	23651099	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:23651099A>T	ENST00000307471.3	+	3	622	c.165A>T	c.(163-165)agA>agT	p.R55S	CCDC126_ENST00000409765.1_Missense_Mutation_p.R55S|CCDC126_ENST00000410069.1_Missense_Mutation_p.R55S|CCDC126_ENST00000486109.1_3'UTR	NM_138771.3	NP_620126.2	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126	55						extracellular region				endometrium(3)|kidney(1)|large_intestine(1)|ovary(1)|skin(1)	7						TAAGCAAAAGATATGTTAAAG	0.383000													11	30					0	0	0.010729	0	0
APOB	338	broad.mit.edu	37	2	21225603	21225603	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:21225603C>A	ENST00000233242.1	-	29	12818	c.12691G>T	c.(12691-12693)Gta>Tta	p.V4231L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4231					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCGAATATACCTGGGACAGT	0.418000													3	38					0.004672	0.0050606	0.004672	1	0
PDGFRA	5156	broad.mit.edu	37	4	55155249	55155249	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:55155249G>T	ENST00000257290.5	+	21	3179	c.2848G>T	c.(2848-2850)Gtg>Ttg	p.V950L	FIP1L1_ENST00000507166.1_Missense_Mutation_p.V710L	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	950	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GAGTGAGATTGTGGAGAATCT	0.488000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			10	28					3.86212e-05	4.72862e-05	0.008291	1	0
CCDC173	129881	broad.mit.edu	37	2	170502615	170502615	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:170502615A>T	ENST00000447353.1	-	9	1500	c.1395T>A	c.(1393-1395)gcT>gcA	p.A465A		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		TCTCCTTTTCAGCCACAAGAG	0.348000													45	277					0	0	0.003610	0	0
MED25	81857	broad.mit.edu	37	19	50340169	50340169	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:50340169A>T	ENST00000312865.6	+	18	2265	c.2212A>T	c.(2212-2214)Atg>Ttg	p.M738L	MED25_ENST00000538643.1_Missense_Mutation_p.M525L	NM_030973.3	NP_112235.2	Q71SY5	MED25_HUMAN	mediator complex subunit 25	738					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)|urinary_tract(1)	17		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		GCCCAGCGTCATGGAGGACGA	0.627000													4	8					0	0	0.009096	0	0
CPN1	1369	broad.mit.edu	37	10	101829578	101829578	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:101829578C>A	ENST00000370418.3	-	3	720	c.469G>T	c.(469-471)Gtg>Ttg	p.V157L		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	157	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TTCAGGTCCACTCCATTTGCA	0.443000													15	67					4.7546e-09	7.13813e-09	0.004007	1	0
GFRAL	389400	broad.mit.edu	37	6	55198732	55198732	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:55198732C>G	ENST00000340465.2	+	3	392	c.306C>G	c.(304-306)atC>atG	p.I102M		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	102						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAAAATGTATCAATAAATCAG	0.284000													21	71					0	0	0.002299	0	0
LRP1B	53353	broad.mit.edu	37	2	141459833	141459833	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:141459833C>A	ENST00000389484.3	-	39	7150	c.6179G>T	c.(6178-6180)cGc>cTc	p.R2060L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2060					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTGTCTGTGCGAGCATCACA	0.378000										TSP Lung(27;0.18)			10	56					3.86212e-05	4.72862e-05	0.008291	1	0
VPRBP	9730	broad.mit.edu	37	3	51458159	51458159	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:51458159C>A	ENST00000335891.5	-	7	927	c.918G>T	c.(916-918)cgG>cgT	p.R306R				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	755					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		AGGCCAGGGCCCGGATTTGGT	0.552000													23	79					4.26978e-12	7.05745e-12	0.003330	1	0
BICC1	80114	broad.mit.edu	37	10	60549116	60549116	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:60549116C>T	ENST00000373886.3	+	7	699	c.695C>T	c.(694-696)tCa>tTa	p.S232L		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	232					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						CAGCATATATCACAAACGTAC	0.418000													10	51					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179659182	179659182	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179659182G>T	ENST00000589042.1	-	8	1566	c.1342C>A	c.(1342-1344)Cag>Aag	p.Q448K	TTN_ENST00000342175.6_Missense_Mutation_p.Q448K|TTN_ENST00000460472.2_Missense_Mutation_p.Q448K|TTN_ENST00000360870.5_Missense_Mutation_p.Q448K|TTN_ENST00000359218.5_Missense_Mutation_p.Q448K|TTN_ENST00000591111.1_Missense_Mutation_p.Q448K|TTN_ENST00000342992.6_Missense_Mutation_p.Q448K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	448							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGCAGTCTGCTCTACAGCG	0.552000													21	101					4.54149e-19	8.5601e-19	0.002299	1	0
OR2T6	254879	broad.mit.edu	37	1	248551251	248551251	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248551251G>C	ENST00000355728.2	+	1	342	c.342G>C	c.(340-342)ctG>ctC	p.L114L		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATTCTTCCTGCTGGGGCTCA	0.567000													6	81					0	0	0.001984	0	0
ASIC4	55515	broad.mit.edu	37	2	220399896	220399896	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:220399896C>G	ENST00000358078.4	+	6	1474	c.1460C>G	c.(1459-1461)tCc>tGc	p.S487C	ASIC4_ENST00000347842.3_Missense_Mutation_p.S468C			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	468						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										GTTGCAGACTCCCTGGGTGGG	0.647000													16	44					0	0	0.007413	0	0
SHPRH	257218	broad.mit.edu	37	6	146271525	146271525	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:146271525T>G	ENST00000367503.3	-	4	1255	c.857A>C	c.(856-858)cAa>cCa	p.Q286P	SHPRH_ENST00000275233.7_Missense_Mutation_p.Q286P|SHPRH_ENST00000367505.2_Missense_Mutation_p.Q286P|SHPRH_ENST00000438092.2_Missense_Mutation_p.Q286P	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	286					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CTGCGTTTCTTGCTGATGTGT	0.473000													29	80					0	0	0.007291	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803266	185803266	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:185803266C>T	ENST00000302277.6	+	4	3737	c.3143C>T	c.(3142-3144)cCa>cTa	p.P1048L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1048						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAAAATGTACCATGTGAGGTC	0.458000													3	50					0	0	0.004672	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43625394	43625394	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:43625394C>A	ENST00000586348.1	+	0	45																											GTAGTCTTCTCCAGGGCTGTA	0.532000													35	284					1.06647e-15	1.9257e-15	0.003755	1	0
SPICE1	152185	broad.mit.edu	37	3	113188063	113188063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:113188063C>A	ENST00000295872.4	-	8	893	c.634G>T	c.(634-636)Gag>Tag	p.E212*		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	212					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						TCAAAATTCTCTTCTGTTAGT	0.308000													12	33					4.36969e-10	6.76712e-10	0.001855	1	0
RSPH10B	222967	broad.mit.edu	37	7	5966163	5966163	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:5966163A>G	ENST00000405415.1	-	20	2835	c.2449T>C	c.(2449-2451)Ttg>Ctg	p.L817L	RSPH10B_ENST00000404406.1_Silent_p.L817L|RSPH10B_ENST00000441023.2_Silent_p.L817L|RSPH10B_ENST00000539903.1_3'UTR|RSPH10B_ENST00000337579.3_Silent_p.L817L			B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B (Chlamydomonas)	817										breast(1)|kidney(1)|lung(4)|ovary(1)|skin(4)	11		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)		TCCTCTCTCAAGATGAAGATG	0.463000													30	123					0	0	0.002836	0	0
SCYL2	55681	broad.mit.edu	37	12	100728014	100728014	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:100728014A>T	ENST00000360820.2	+	14	2269	c.1832A>T	c.(1831-1833)gAg>gTg	p.E611V		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	611					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						ACTAAACTGGAGCAACTTCAT	0.328000													16	36					0	0	0.008871	0	0
RPAP1	26015	broad.mit.edu	37	15	41829177	41829177	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:41829177C>G	ENST00000304330.4	-	2	263	c.147G>C	c.(145-147)ccG>ccC	p.P49P	RPAP1_ENST00000561603.1_Silent_p.P49P	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	49						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGTCCTGGAGCGGAGGCCGGT	0.582000													22	101					0	0	0.003330	0	0
CSN2	1447	broad.mit.edu	37	4	70823204	70823204	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:70823204G>T	ENST00000353151.3	-	5	474	c.463C>A	c.(463-465)Cag>Aag	p.Q155K		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	155					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						GGAATAGGCTGAGGGACCTGC	0.537000													9	26					1.76689e-08	2.57834e-08	0.006214	1	0
FAM129A	116496	broad.mit.edu	37	1	184764954	184764954	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:184764954G>A	ENST00000367511.3	-	14	2137	c.1944C>T	c.(1942-1944)ccC>ccT	p.P648P	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	648					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TCCCATCTGGGGGTGGGCTTG	0.557000													14	46					0	0	0.004007	0	0
DGKE	8526	broad.mit.edu	37	17	54912249	54912249	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:54912249G>T	ENST00000284061.3	+	2	273	c.93G>T	c.(91-93)ctG>ctT	p.L31L	DGKE_ENST00000576869.1_3'UTR|C17orf67_ENST00000487705.1_Intron|DGKE_ENST00000572810.1_Silent_p.L31L	NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	31					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					GCTCGGTCCTGCTGCCGGTGT	0.677000													32	177					4.74835e-14	8.31204e-14	0.010818	1	0
GABRA4	2557	broad.mit.edu	37	4	46930604	46930604	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:46930604G>T	ENST00000264318.3	-	9	2285	c.1303C>A	c.(1303-1305)Cca>Aca	p.P435T		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	435					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CGGCTGAATGGGTTTGGACTG	0.463000													21	65					2.27525e-19	4.3122e-19	0.003954	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48913470	48913470	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:48913470G>T	ENST00000311378.4	+	1	700	c.172G>T	c.(172-174)Gca>Tca	p.A58S	WFIKKN2_ENST00000426127.1_Intron	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	58	WAP.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGGGTGGACGCACAGAGCAC	0.667000													12	11					5.50884e-06	7.0564e-06	0.001368	1	0
FERD3L	222894	broad.mit.edu	37	7	19184587	19184587	+	Nonsense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:19184587G>C	ENST00000275461.3	-	1	457	c.399C>G	c.(397-399)taC>taG	p.Y133*	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	133	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						GCCTTTTCTCGTAAGCAAACG	0.587000													7	32					0	0	0.003080	0	0
FLG	2312	broad.mit.edu	37	1	152280612	152280612	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152280612C>T	ENST00000368799.1	-	3	6785	c.6750G>A	c.(6748-6750)gaG>gaA	p.E2250E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2250	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTGTCCCTCACTGTCAC	0.587000									Ichthyosis				64	240					0	0	0.003610	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178081299	178081299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:178081299C>T	ENST00000411529.2	+	5	607	c.556C>T	c.(556-558)Cag>Tag	p.Q186*	HNRNPA3_ENST00000435711.1_Nonsense_Mutation_p.Q208*|HNRNPA3_ENST00000392524.2_Nonsense_Mutation_p.Q208*	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	208	RRM 2.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						ACAAGAGATGCAGTCTGCTGG	0.358000													10	156					0	0	0.001368	0	0
APOB	338	broad.mit.edu	37	2	21249662	21249662	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:21249662G>T	ENST00000233242.1	-	15	2369	c.2242C>A	c.(2242-2244)Cag>Aag	p.Q748K	APOB_ENST00000399256.4_Missense_Mutation_p.Q748K	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	748					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATACACACCTGCTCATGTTTA	0.378000													4	52					0.00909568	0.00969341	0.009096	1	0
DEFB113	245927	broad.mit.edu	37	6	49936501	49936501	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:49936501G>A	ENST00000398718.1	-	2	137	c.138C>T	c.(136-138)tgC>tgT	p.C46C		NM_001037729.1	NP_001032818.1	Q30KQ7	DB113_HUMAN	defensin, beta 113	46					defense response to bacterium	extracellular region				breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Lung NSC(77;0.042)					CCCAGCTGTTGCATTCCGGCT	0.403000													4	18					0	0	0.009096	0	0
FBN2	2201	broad.mit.edu	37	5	127685063	127685063	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:127685063C>A	ENST00000508053.1	-	29	3939	c.2965G>T	c.(2965-2967)Gat>Tat	p.D989Y	FBN2_ENST00000262464.4_Missense_Mutation_p.D989Y|FBN2_ENST00000508989.1_Missense_Mutation_p.D956Y			P35556	FBN2_HUMAN	fibrillin 2	989	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCAGTCCCATCCAACGTAAGG	0.453000													9	10					1.12685e-05	1.4264e-05	0.004482	1	0
OR10J1	26476	broad.mit.edu	37	1	159409967	159409967	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:159409967C>T	ENST00000423932.3	+	1	456	c.419C>T	c.(418-420)cCc>cTc	p.P140L	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	140					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					ATCTGCAACCCCCTGAGATAC	0.488000													23	87					0	0	0.002299	0	0
BTBD9	114781	broad.mit.edu	37	6	38560523	38560523	+	Nonsense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:38560523T>A	ENST00000481247.1	-	4	794	c.643A>T	c.(643-645)Aag>Tag	p.K215*	BTBD9_ENST00000419706.2_Nonsense_Mutation_p.K156*|BTBD9_ENST00000314100.6_Nonsense_Mutation_p.K147*|BTBD9_ENST00000408958.1_Nonsense_Mutation_p.K147*|BTBD9_ENST00000403056.1_Nonsense_Mutation_p.K215*	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	215	BACK.				cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						TGATTCTCCTTTGAATTGTGC	0.428000													6	34					0	0	0.001168	0	0
SPEF2	79925	broad.mit.edu	37	5	35753794	35753794	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:35753794C>A	ENST00000440995.2	+	24	3384	c.3384C>A	c.(3382-3384)gaC>gaA	p.D1128E	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.D1133E			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1133					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGCGGCTTGACATCATTAATG	0.507000													34	214					4.4194e-11	7.11992e-11	0.002836	1	0
ZNF669	79862	broad.mit.edu	37	1	247263971	247263971	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247263971C>A	ENST00000343381.6	-	4	1272	c.1100G>T	c.(1099-1101)tGt>tTt	p.C367F	ZNF669_ENST00000358785.4_3'UTR|ZNF669_ENST00000448299.2_Missense_Mutation_p.C281F	NM_024804.2	NP_079080.2	Q96BR6	ZN669_HUMAN	zinc finger protein 669	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(2)|lung(6)	17	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GGCTTTGCCACATTGTTTACA	0.408000													21	71					1.28384e-07	1.79863e-07	0.012319	1	0
MYPN	84665	broad.mit.edu	37	10	69909816	69909816	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:69909816A>G	ENST00000358913.5	+	6	1753	c.1265A>G	c.(1264-1266)tAc>tGc	p.Y422C	MYPN_ENST00000354393.2_Missense_Mutation_p.Y147C|MYPN_ENST00000373675.3_Missense_Mutation_p.Y422C|MYPN_ENST00000540630.1_Missense_Mutation_p.Y422C	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	422	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CCCACCAATTACTTGCAGGGA	0.358000													6	45					0	0	0.001984	0	0
PAMR1	25891	broad.mit.edu	37	11	35456112	35456112	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:35456112C>A	ENST00000378880.2	-	10	2019	c.1574G>T	c.(1573-1575)gGg>gTg	p.G525V	PAMR1_ENST00000532848.1_Missense_Mutation_p.G485V|PAMR1_ENST00000378878.3_Missense_Mutation_p.G414V|PAMR1_ENST00000278360.3_Missense_Mutation_p.G542V	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	525	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						GTAGAATTTCCCCAAAACAAC	0.537000													7	72					8.12818e-05	9.70302e-05	0.001984	1	0
CCT8L2	150160	broad.mit.edu	37	22	17073318	17073318	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:17073318C>T	ENST00000359963.3	-	1	382	c.123G>A	c.(121-123)caG>caA	p.Q41Q		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	41					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGCCAGGGTCTGGACTGCAG	0.647000													10	40					0	0	0.006214	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457187	110457187	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:110457187C>T	ENST00000378402.5	+	38	5193	c.5089C>T	c.(5089-5091)Cat>Tat	p.H1697Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1697	IPT/TIG 9.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCTTATGGGTCATTTCCCATG	0.438000										HNSCC(38;0.096)			53	77					0	0	0.003610	0	0
OR10H5	284433	broad.mit.edu	37	19	15905108	15905108	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:15905108G>A	ENST00000308940.8	+	1	348	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CATGCTGGCCGACCTGCTGTC	0.612000													6	74					0	0	0.001984	0	0
ZBTB11	27107	broad.mit.edu	37	3	101384010	101384010	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:101384010C>A	ENST00000312938.4	-	4	2001	c.1421G>T	c.(1420-1422)aGg>aTg	p.R474M		NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AACTTTCTGCCTATGTTTTGG	0.393000													26	76					7.33532e-06	9.382e-06	0.003954	1	0
NOTCH4	4855	broad.mit.edu	37	6	32183075	32183075	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:32183075A>T	ENST00000375023.3	-	12	2087	c.1949T>A	c.(1948-1950)cTc>cAc	p.L650H		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	650	EGF-like 16.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						ATCAGGACAGAGGCAGTTGGC	0.602000													4	16					0	0	0.009096	0	0
SEMA3E	9723	broad.mit.edu	37	7	83036427	83036427	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:83036427C>A	ENST00000307792.3	-	7	1266	c.799G>T	c.(799-801)Ggg>Tgg	p.G267W	SEMA3E_ENST00000427262.1_Missense_Mutation_p.G207W	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	267	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				CAGAGTCGCCCGACCCTGGTG	0.393000													18	46					1.15919e-05	1.46626e-05	0.008871	1	0
AGRN	375790	broad.mit.edu	37	1	982115	982115	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:982115G>T	ENST00000379370.2	+	18	3300	c.3250_splice	c.e18+1	p.G1084_splice		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1084	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TGGCTCTGGGGGTGAGCAGGG	0.672000													5	5					0.000602214	0.000681505	0.000602	1	0
TMTC1	83857	broad.mit.edu	37	12	29904677	29904677	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:29904677C>A	ENST00000256062.5	-	5	1009	c.536G>T	c.(535-537)gGc>gTc	p.G179V	TMTC1_ENST00000551659.1_Missense_Mutation_p.G287V|TMTC1_ENST00000552618.1_Missense_Mutation_p.G287V|TMTC1_ENST00000381224.2_Missense_Mutation_p.G179V|TMTC1_ENST00000539277.1_Missense_Mutation_p.G287V	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	287						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AGAGTGGCAGCCACCCCAAGC	0.627000													13	36					5.50884e-06	7.0564e-06	0.001368	1	0
CCT3	7203	broad.mit.edu	37	1	156280816	156280816	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:156280816C>A	ENST00000295688.3	-	12	1606	c.1326G>T	c.(1324-1326)caG>caT	p.Q442H	CCT3_ENST00000368261.3_Missense_Mutation_p.Q397H|CCT3_ENST00000368259.2_Missense_Mutation_p.Q404H|CCT3_ENST00000472765.2_Missense_Mutation_p.Q397H	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	442					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CCTCTAGGGCCTGGGCAACAG	0.577000													7	67					0.000157383	0.000184418	0.003080	1	0
GABRA6	2559	broad.mit.edu	37	5	161113970	161113970	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:161113970T>C	ENST00000523217.1	+	3	428	c.186T>C	c.(184-186)atT>atC	p.I62I	GABRA6_ENST00000274545.5_Silent_p.I62I|GABRA6_ENST00000522269.1_3'UTR	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	62					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAACAGACATTTATGTGACCA	0.458000										TCGA Ovarian(5;0.080)			3	53					0	0	0.004672	0	0
PLIN4	729359	broad.mit.edu	37	19	4511323	4511323	+	Silent	SNP	G	G	T	rs71263980		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:4511323G>T	ENST00000301286.3	-	3	2606	c.2607C>A	c.(2605-2607)ggC>ggA	p.G869G		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	869	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TAGTGTCCAGGCCCCCCTGGA	0.587000													10	85					4.68919e-08	6.75102e-08	0.008291	1	0
UGT3A1	133688	broad.mit.edu	37	5	35957310	35957310	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:35957310A>C	ENST00000274278.3	-	5	1412	c.1055T>G	c.(1054-1056)cTt>cGt	p.L352R	UGT3A1_ENST00000513233.1_5'UTR|UGT3A1_ENST00000503189.1_Missense_Mutation_p.L352R|UGT3A1_ENST00000507113.1_Missense_Mutation_p.L318R	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	352						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACTCTGAGGAAGCCAGTCCAC	0.512000													4	65					0	0	0.000602	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209195317	209195317	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:209195317G>T	ENST00000264380.4	+	23	4020	c.3862G>T	c.(3862-3864)Ggc>Tgc	p.G1288C		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1288					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CTTTGTTCATGGCCAAGGCTG	0.438000													28	156					3.65163e-15	6.57293e-15	0.006320	1	0
MCTP1	79772	broad.mit.edu	37	5	94353173	94353173	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:94353173C>G	ENST00000515393.1	-	2	735	c.736G>C	c.(736-738)Gct>Cct	p.A246P	MCTP1_ENST00000505208.1_Missense_Mutation_p.A25P|MCTP1_ENST00000312216.8_Missense_Mutation_p.A25P|MCTP1_ENST00000429576.2_Missense_Mutation_p.A25P	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	246					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CTGGTTCCAGCAGTGTTTATT	0.383000													15	22					0	0	0.002450	0	0
CPSF3L	54973	broad.mit.edu	37	1	1256375	1256375	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:1256375C>A	ENST00000540437.1	-	4	600		c.e4+1		CPSF3L_ENST00000421495.2_Intron|CPSF3L_ENST00000411962.1_Intron|CPSF3L_ENST00000545578.1_Splice_Site|CPSF3L_ENST00000419704.1_Splice_Site|CPSF3L_ENST00000450926.2_Splice_Site|CPSF3L_ENST00000435064.1_Splice_Site	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like							Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		AAGGGACTCACGTCGTCATTG	0.652000													16	61					0.00316338	0.00347245	0.003163	1	0
MBL2	4153	broad.mit.edu	37	10	54531239	54531239	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:54531239C>A	ENST00000373968.3	-	1	221	c.157G>T	c.(157-159)Gat>Tat	p.D53Y		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	53	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						TTGGTGCCATCACGCCCATCT	0.542000													10	38					4.68919e-08	6.75102e-08	0.008291	1	0
MYO7A	4647	broad.mit.edu	37	11	76867736	76867736	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:76867736C>A	ENST00000409709.3	+	6	773	c.501C>A	c.(499-501)agC>agA	p.S167R	MYO7A_ENST00000409893.1_Missense_Mutation_p.S167R|MYO7A_ENST00000458637.2_Missense_Mutation_p.S167R|MYO7A_ENST00000409619.2_Missense_Mutation_p.S156R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	167	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						AGACGGAGAGCACAAAGCTGA	0.612000													36	39					5.8336e-16	1.05669e-15	0.003271	1	0
OSMR	9180	broad.mit.edu	37	5	38933124	38933124	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:38933124C>G	ENST00000274276.3	+	18	2920	c.2518C>G	c.(2518-2520)Ctc>Gtc	p.L840V		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	840					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CTACCTTTATCTCCTTCCAAC	0.468000													115	116					0	0	0.003610	0	0
OR4M1	441670	broad.mit.edu	37	14	20249031	20249031	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20249031G>T	ENST00000315957.4	+	1	631	c.550G>T	c.(550-552)Gtt>Ttt	p.V184F		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATCACACAGGTTGTCCGGAT	0.468000													14	164					2.4624e-09	3.73928e-09	0.008871	1	0
GABRG1	2565	broad.mit.edu	37	4	46067421	46067421	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:46067421G>A	ENST00000295452.4	-	4	669	c.502C>T	c.(502-504)Ctt>Ttt	p.L168F		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	168					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CAAATTCGAAGCAGACGATTA	0.333000													4	26					0	0	0.009096	0	0
OR2W5	441932	broad.mit.edu	37	1	247654475	247654475	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247654475G>T	ENST00000522351.1	+	0	106							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CATCCTGGTGGGCTCTTCTGA	0.478000													13	52					2.61681e-11	4.23569e-11	0.002450	1	0
MYH1	4619	broad.mit.edu	37	17	10404639	10404639	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:10404639G>T	ENST00000226207.5	-	27	3620	c.3526C>A	c.(3526-3528)Cag>Aag	p.Q1176K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1176						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CGCATTTTCTGGAACTCAGCC	0.612000													45	46					6.61955e-31	1.31854e-30	0.003610	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144903151	144903151	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:144903151C>A	ENST00000529945.1	-	17	3669	c.3230G>T	c.(3229-3231)cGc>cTc	p.R1077L	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R914L|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R1051L|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.R701L|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R914L|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R914L|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.R1051L|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R914L|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R1077L|PDE4DIP_ENST00000524974.1_Intron|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R980L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	914					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TAGCCGACTGCGTAACACCTG	0.522000			T	PDGFRB	MPD								67	129					8.52622e-23	1.65238e-22	0.003610	1	0
ST8SIA4	7903	broad.mit.edu	37	5	100147663	100147663	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:100147663C>A	ENST00000231461.5	-	5	1278	c.968G>T	c.(967-969)aGg>aTg	p.R323M		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	323					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GGAAAAGTACCTATATTTTAA	0.353000													6	10					2.0095e-06	2.66743e-06	0.001984	1	0
CSMD3	114788	broad.mit.edu	37	8	113293519	113293519	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:113293519G>T	ENST00000297405.5	-	59	9636	c.9392C>A	c.(9391-9393)aCa>aAa	p.T3131K	CSMD3_ENST00000455883.2_Missense_Mutation_p.T2962K|CSMD3_ENST00000343508.3_Missense_Mutation_p.T3091K|CSMD3_ENST00000352409.3_Missense_Mutation_p.T3061K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3131	Sushi 23.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGAAAATGTTGTGCCATCAAT	0.413000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	14					0.00010058	0.000119569	0.001368	1	0
SYNDIG1	79953	broad.mit.edu	37	20	24524197	24524197	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:24524197A>G	ENST00000376862.3	+	2	1097	c.464A>G	c.(463-465)gAg>gGg	p.E155G		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	155	Poly-Glu.				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						GAGGAGGAGGAGTTCCAGGAG	0.527000													10	115					0	0	0.007413	0	0
CLEC12B	387837	broad.mit.edu	37	12	10167231	10167231	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:10167231C>A	ENST00000396502.1	+	3	428	c.300C>A	c.(298-300)aaC>aaA	p.N100K	CLEC12B_ENST00000338896.5_Missense_Mutation_p.N100K	NM_205852.2	NP_995324.2	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B	100						integral to membrane|plasma membrane	receptor activity|sugar binding			central_nervous_system(2)|large_intestine(2)|lung(5)	9						GCAACTCCAACAACTTGTCCA	0.428000													12	33					7.03913e-09	1.04583e-08	0.001368	1	0
TPR	7175	broad.mit.edu	37	1	186340118	186340118	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:186340118C>G	ENST00000367478.3	-	3	610	c.314G>C	c.(313-315)cGc>cCc	p.R105P	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	105					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GGCAATATTGCGATCCTGAGC	0.313000			T	NTRK1	papillary thyroid								8	49					0	0	0.004482	0	0
IL16	3603	broad.mit.edu	37	15	81561978	81561978	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:81561978G>T	ENST00000394660.2	+	5	1024	c.664G>T	c.(664-666)Ggc>Tgc	p.G222C	IL16_ENST00000302987.4_Missense_Mutation_p.G222C	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	222	Interaction with GRIN2A.|PDZ 1.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCTGATGAAGGGCCAGGCTAA	0.592000													54	30					4.25531e-23	8.31237e-23	0.003610	1	0
LILRA5	353514	broad.mit.edu	37	19	54818758	54818758	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:54818758C>A	ENST00000301219.3	-	7	959	c.840G>T	c.(838-840)ggG>ggT	p.G280G	LILRA5_ENST00000346508.3_Silent_p.G268G	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	280					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATATCAGAATCCCAAGGACCA	0.532000													32	15					1.30988e-24	2.57335e-24	0.010818	1	0
CSN2	1447	broad.mit.edu	37	4	70825776	70825776	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:70825776T>C	ENST00000353151.3	-	2	84	c.73A>G	c.(73-75)Agt>Ggt	p.S25G		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	25					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						CTTACCTCACTGCTTGAAAGG	0.323000													4	13					0	0	0.009096	0	0
OR2T10	127069	broad.mit.edu	37	1	248756958	248756958	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248756958C>A	ENST00000330500.2	-	1	142	c.112G>T	c.(112-114)Gct>Tct	p.A38S		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A38S(1)		breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGACACAGCCATCAAAAAT	0.443000													13	42					0.00010058	0.000119569	0.001368	1	0
NDST4	64579	broad.mit.edu	37	4	115792057	115792057	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:115792057C>A	ENST00000264363.2	-	7	2264	c.1586G>T	c.(1585-1587)gGg>gTg	p.G529V		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	529	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGTATATAACCCTAGGCGGTC	0.388000													8	30					5.4927e-09	8.18194e-09	0.004482	1	0
MAGI2	9863	broad.mit.edu	37	7	79082635	79082635	+	Translation_Start_Site	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:79082635A>G	ENST00000354212.4	-	1	255	c.2T>C	c.(1-3)aTg>aCg	p.M1T	MAGI2_ENST00000522391.1_Start_Codon_SNP_p.M1T|MAGI2-AS3_ENST00000429408.1_RNA|MAGI2-AS3_ENST00000446159.1_RNA|MAGI2_ENST00000419488.1_Start_Codon_SNP_p.M1T|MAGI2-AS3_ENST00000426835.1_RNA	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GCTTTTGGACATGGCAGTGGG	0.587000													11	95					0	0	0.001368	0	0
NCF1	653361	broad.mit.edu	37	7	74191693	74191693	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:74191693T>A	ENST00000289473.4	+	2	223	c.153_splice	c.e2+1	p.H51_splice	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	51	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						ACGAGTTCCATGTGAGTGTGG	0.587000													9	22					0	0	0.008291	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651720	84651720	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:84651720G>C	ENST00000286744.5	+	21	3564	c.3340G>C	c.(3340-3342)Gat>Cat	p.D1114H	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.D1114H	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1114						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGAGGTCAGCGATGATCTTGC	0.512000													12	30					0	0	0.010729	0	0
TET1	80312	broad.mit.edu	37	10	70446225	70446225	+	Missense_Mutation	SNP	A	A	G	rs141820172		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:70446225A>G	ENST00000373644.4	+	11	5374	c.5165A>G	c.(5164-5166)aAg>aGg	p.K1722R		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1722					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TTTGGCTCCAAGGAAGGAATG	0.498000													28	93					0	0	0.004656	0	0
FSCB	84075	broad.mit.edu	37	14	44975324	44975324	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:44975324G>C	ENST00000340446.4	-	1	1158	c.867C>G	c.(865-867)acC>acG	p.T289T		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	289						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CTTGGACATGGGTCTCTTCAG	0.493000													4	39					0	0	0.009096	0	0
APOB	338	broad.mit.edu	37	2	21234458	21234458	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:21234458C>A	ENST00000233242.1	-	26	5409	c.5282G>T	c.(5281-5283)gGc>gTc	p.G1761V		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1761					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGTGATAAGCCTGCAATGTT	0.383000													54	50					2.76378e-25	5.44833e-25	0.003610	1	0
PIK3C2A	5286	broad.mit.edu	37	11	17111392	17111392	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:17111392G>C	ENST00000265970.7	-	32	4953	c.4954C>G	c.(4954-4956)Ctg>Gtg	p.L1652V	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.L1272V|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1652	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TTCTCCCGCAGAGATTCTGCA	0.413000													18	99					0	0	0.007413	0	0
APOB	338	broad.mit.edu	37	2	21228567	21228567	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:21228567C>A	ENST00000233242.1	-	26	11300	c.11173G>T	c.(11173-11175)Gtt>Ttt	p.V3725F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3725					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAGCCAAAACTTTTACAGGG	0.408000													7	73					1.06961e-07	1.51455e-07	0.003080	1	0
ZNF460	10794	broad.mit.edu	37	19	57803294	57803294	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:57803294A>G	ENST00000360338.3	+	3	1707	c.1385A>G	c.(1384-1386)aAc>aGc	p.N462S	ZNF460_ENST00000537645.1_Missense_Mutation_p.N421S	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGGACCACAAACCTGATTCGA	0.532000													14	36					0	0	0.003163	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176765161	176765161	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:176765161T>A	ENST00000430069.1	-	9	1050	c.791A>T	c.(790-792)cAg>cTg	p.Q264L	TBL1XR1_ENST00000457928.2_Missense_Mutation_p.Q264L|TBL1XR1-AS1_ENST00000454723.2_RNA			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	264					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			GCCTTTATGCTGCCCTAAGGT	0.318000													4	6					0	0	0.009096	0	0
TRIML1	339976	broad.mit.edu	37	4	189067976	189067976	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:189067976C>T	ENST00000332517.3	+	6	997	c.856_splice	c.e6-1	p.T286_splice	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	286	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding	p.T286K(1)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCTCTTGCAGCGGAGATAACG	0.468000													36	117					0	0	0.005524	0	0
HAVCR2	84868	broad.mit.edu	37	5	156533651	156533651	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:156533651C>A	ENST00000307851.4	-	2	1111	c.381G>T	c.(379-381)ttG>ttT	p.L127F	HAVCR2_ENST00000522593.1_Missense_Mutation_p.L127F|CTB-120L21.1_ENST00000517708.1_RNA	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	127						integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTTGATGACCAACTTCAGGT	0.408000													6	17					0.00116845	0.00130426	0.001168	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113518730	113518730	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:113518730C>A	ENST00000284601.3	-	4	2485	c.2417G>T	c.(2416-2418)cGt>cTt	p.R806L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	806					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AATACCTAAACGTGATTCCTT	0.373000													19	61					3.99206e-14	7.00239e-14	0.007413	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38651256	38651256	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:38651256C>A	ENST00000494540.1	+	0	403					NR_003086.1																						TCTCTTTGGCCTCTTTTCAAG	0.378000													15	28					1.52009e-12	2.56683e-12	0.003163	1	0
ONECUT2	9480	broad.mit.edu	37	18	55103647	55103647	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:55103647C>T	ENST00000491143.2	+	1	731	c.699C>T	c.(697-699)ggC>ggT	p.G233G		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	233					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		CGCCGCTGGGCAACGGGCTAG	0.672000													3	19					0	0	0.009096	0	0
USHBP1	83878	broad.mit.edu	37	19	17369165	17369165	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:17369165A>G	ENST00000252597.3	-	8	1249	c.1076T>C	c.(1075-1077)cTg>cCg	p.L359P	USHBP1_ENST00000431146.2_Missense_Mutation_p.L295P	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	359							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						CAGAGCAAGCAGAACCCTGTA	0.582000													10	30					0	0	0.006214	0	0
SYT3	84258	broad.mit.edu	37	19	51135839	51135839	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51135839C>G	ENST00000338916.4	-	2	1011	c.378G>C	c.(376-378)ctG>ctC	p.L126L	SYT3_ENST00000593901.1_Silent_p.L126L|SYT3_ENST00000600079.1_Silent_p.L126L|SYT3_ENST00000544769.1_Silent_p.L126L	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	126						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GGCCGCCCAGCAGAGGATGGC	0.711000													6	5					0	0	0.001168	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5303493	5303493	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:5303493A>G	ENST00000274181.7	+	19	3040	c.2902A>G	c.(2902-2904)Agc>Ggc	p.S968G		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	968	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AGTCCCGGCCAGCCTGTGCCC	0.697000													10	31					0	0	0.006214	0	0
VCAN	1462	broad.mit.edu	37	5	82841407	82841407	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:82841407C>A	ENST00000265077.3	+	9	9882	c.9317C>A	c.(9316-9318)cCt>cAt	p.P3106H	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000512590.2_Missense_Mutation_p.P1304H|VCAN_ENST00000343200.5_Missense_Mutation_p.P2119H|VCAN_ENST00000342785.4_Missense_Mutation_p.P1352H|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Missense_Mutation_p.P365H|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3106	EGF-like 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACCTGTTATCCTACTGAAACT	0.468000													32	91					1.80694e-10	2.84445e-10	0.009535	1	0
PGBD1	84547	broad.mit.edu	37	6	28251657	28251657	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:28251657G>T	ENST00000405948.2	+	2	487	c.67G>T	c.(67-69)Gat>Tat	p.D23Y	PGBD1_ENST00000259883.3_Missense_Mutation_p.D23Y	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	23					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						GAAGGAGGAAGATCCCACCTG	0.537000													14	117					1.5842e-08	2.33354e-08	0.001855	1	0
ABCA8	10351	broad.mit.edu	37	17	66925834	66925834	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:66925834C>T	ENST00000269080.2	-	7	944	c.807G>A	c.(805-807)tgG>tgA	p.W269*	ABCA8_ENST00000586539.1_Nonsense_Mutation_p.W269*|ABCA8_ENST00000430352.2_Nonsense_Mutation_p.W269*	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	269						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					AGAGCAAACCCCAGGAGAGCC	0.363000													7	13					0	0	0.001984	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184612552	184612552	+	Silent	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:184612552A>C	ENST00000334690.6	+	19	2179	c.1977A>C	c.(1975-1977)ctA>ctC	p.L659L	TRAPPC11_ENST00000357207.4_Silent_p.L659L|TRAPPC11_ENST00000512476.1_Silent_p.L265L	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	659																	AGATGTGCCTAGTTCCTGGCA	0.323000													7	26					0	0	0.001984	0	0
NTN3	4917	broad.mit.edu	37	16	2522510	2522510	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2522510G>T	ENST00000293973.1	+	1	1011	c.808G>T	c.(808-810)Ggc>Tgc	p.G270C		NM_006181.2	NP_006172.1	O00634	NET3_HUMAN	netrin 3	270	Laminin EGF-like 1.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				breast(1)|central_nervous_system(2)|lung(3)|prostate(1)	7						GGACACACAGGGCCACCTGAT	0.682000													7	32					5.18039e-06	6.69053e-06	0.003080	1	0
OBSCN	84033	broad.mit.edu	37	1	228505766	228505766	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:228505766G>C	ENST00000570156.2	+	64	16968	c.16894G>C	c.(16894-16896)Ggt>Cgt	p.G5632R	OBSCN_ENST00000366707.4_Missense_Mutation_p.G2309R|OBSCN_ENST00000284548.11_Missense_Mutation_p.G4675R|OBSCN_ENST00000366709.4_Missense_Mutation_p.G1794R|OBSCN_ENST00000422127.1_Missense_Mutation_p.G4675R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4675	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGTCTCCCAGGGTCGGCAACA	0.642000													19	72					0	0	0.010504	0	0
MMP16	4325	broad.mit.edu	37	8	89068387	89068387	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:89068387C>A	ENST00000286614.6	-	8	1623	c.1342G>T	c.(1342-1344)Gtc>Ttc	p.V448F		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	448	Hemopexin-like 3.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding	p.V448I(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GTTTTCCCGACGTCCTCCCAC	0.413000													10	32					2.17888e-05	2.72201e-05	0.006214	1	0
SMO	6608	broad.mit.edu	37	7	128849169	128849169	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:128849169C>A	ENST00000249373.3	+	8	1677	c.1397C>A	c.(1396-1398)aCc>aAc	p.T466N		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	466					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GTGCTCATTACCTTCAGCTGC	0.592000			Mis		skin basal cell								29	54					5.45727e-16	9.89562e-16	0.008361	1	0
CCNE1	898	broad.mit.edu	37	19	30308449	30308449	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:30308449G>T	ENST00000357943.5	+	6	636	c.463G>T	c.(463-465)Gtg>Ttg	p.V155L	CCNE1_ENST00000262643.3_Splice_Site|CCNE1_ENST00000444983.2_Splice_Site			P24864	CCNE1_HUMAN	cyclin E1	155					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			GTTAATGGAGGTGAGCTTGAG	0.433000			A		serous ovarian								15	82					0.000308642	0.0003556	0.003163	1	0
TRAV8-7	28679	broad.mit.edu	37	14	22600744	22600744	+	RNA	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22600744T>C	ENST00000390456.3	+	0	89																											CACATCACTGTCTCTGAAGAA	0.483000													10	26					0	0	0.006214	0	0
NCAN	1463	broad.mit.edu	37	19	19338321	19338321	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:19338321C>A	ENST00000252575.5	+	8	1935	c.1892C>A	c.(1891-1893)cCt>cAt	p.P631H	NCAN_ENST00000538881.1_Missense_Mutation_p.P82H	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	631					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CCAGATCTCCCTATGATGGCC	0.632000													12	33					6.40141e-05	7.73298e-05	0.010729	1	0
KCNH8	131096	broad.mit.edu	37	3	19575573	19575573	+	Missense_Mutation	SNP	C	C	A	rs74606615		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:19575573C>A	ENST00000328405.2	+	16	3572	c.3306C>A	c.(3304-3306)aaC>aaA	p.N1102K		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1102						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TGAAAGATAACAAAGCCATAA	0.438000													9	10					0.000442599	0.00050587	0.006214	1	0
ANKRD49	54851	broad.mit.edu	37	11	94230194	94230194	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:94230194G>T	ENST00000544253.1	+	2	453	c.335G>T	c.(334-336)tGt>tTt	p.C112F	ANKRD49_ENST00000302755.4_Intron|ANKRD49_ENST00000544612.1_Intron|ANKRD49_ENST00000540349.1_Missense_Mutation_p.C112F			Q8WVL7	ANR49_HUMAN	ankyrin repeat domain 49	0					positive regulation of transcription, DNA-dependent					autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|urinary_tract(1)	12		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGCCTTTACTGTTATGGCCAT	0.398000													18	58					2.48551e-13	4.25133e-13	0.004990	1	0
CTDSP2	10106	broad.mit.edu	37	12	58220837	58220837	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:58220837T>C	ENST00000398073.2	-	4	599	c.296A>G	c.(295-297)cAa>cGa	p.Q99R	CTDSP2_ENST00000548823.1_Intron|CTDSP2_ENST00000547701.1_5'UTR	NM_005730.3	NP_005721.3	O14595	CTDS2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	99	FCP1 homology.				protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					GATCCTTCCTTGATCTTCCTC	0.502000													26	39					0	0	0.005443	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47585760	47585760	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:47585760G>A	ENST00000371917.4	+	9	1136	c.1136G>A	c.(1135-1137)cGc>cAc	p.R379H		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	379					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CTTGTGTTCCGCTCCCTGTGC	0.532000													14	51					0	0	0.004007	0	0
SPIDR	23514	broad.mit.edu	37	8	48614372	48614372	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:48614372C>T	ENST00000297423.4	+	13	2247	c.1863C>T	c.(1861-1863)ccC>ccT	p.P621P	SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000541342.1_Silent_p.P551P|SPIDR_ENST00000517693.1_Silent_p.P96P|SPIDR_ENST00000518074.1_Silent_p.P561P	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		ACGAAGACCCCATTTATAAGC	0.413000													31	123					0	0	0.010818	0	0
GMDS	2762	broad.mit.edu	37	6	1961137	1961137	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:1961137C>A	ENST00000380815.4	-	5	678	c.409G>T	c.(409-411)Gat>Tat	p.D137Y	GMDS_ENST00000530927.1_Missense_Mutation_p.D107Y	NM_001500.3	NP_001491.1	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	137					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity		GMDS/PDE8B(2)	breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|prostate(1)	21	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TTAACTGCATCTAGAAGTCGT	0.478000													27	36					1.26454e-06	1.70356e-06	0.005443	1	0
DNMBP	23268	broad.mit.edu	37	10	101716779	101716779	+	Missense_Mutation	SNP	C	C	A	rs138795130		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:101716779C>A	ENST00000342239.3	-	4	543	c.452G>T	c.(451-453)cGg>cTg	p.R151L	DNMBP_ENST00000324109.4_Missense_Mutation_p.R151L|DNMBP-AS1_ENST00000434409.1_RNA			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	151	SH3 3.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CATTAGGGCCCGGGCTTGTCC	0.557000													9	33					0.00448238	0.00490153	0.004482	1	0
DCLK1	9201	broad.mit.edu	37	13	36367543	36367543	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:36367543G>T	ENST00000255448.4	-	16	2229	c.2018C>A	c.(2017-2019)cCc>cAc	p.P673H	DCLK1_ENST00000379893.1_Missense_Mutation_p.P366H|DCLK1_ENST00000360631.3_Missense_Mutation_p.P673H	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	673					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ATTCGGCTTGGGGCCTGTGTT	0.428000													48	47					1.35964e-18	2.55155e-18	0.003610	1	0
SSTR4	6754	broad.mit.edu	37	20	23016573	23016573	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:23016573T>A	ENST00000255008.3	+	1	517	c.453T>A	c.(451-453)ccT>ccA	p.P151P	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	151					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGGTGCACCCTCTGCGCGCGG	0.667000													14	49					0	0	0.004007	0	0
VAV3	10451	broad.mit.edu	37	1	108313279	108313279	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:108313279T>G	ENST00000370056.4	-	6	901	c.627A>C	c.(625-627)gaA>gaC	p.E209D	VAV3_ENST00000371846.4_Missense_Mutation_p.E144D|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000527011.1_Missense_Mutation_p.E209D	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	209	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ACTCCAAAGTTTCTGTATATT	0.299000													5	43					0	0	0.000602	0	0
TLL1	7092	broad.mit.edu	37	4	166929094	166929094	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:166929094G>T	ENST00000061240.2	+	7	1458		c.e7-1		TLL1_ENST00000513213.1_Splice_Site|TLL1_ENST00000507499.1_Splice_Site	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CTGGTTCTTAGGTCAAGAGTA	0.403000													12	35					5.50884e-06	7.0564e-06	0.001368	1	0
FAT1	2195	broad.mit.edu	37	4	187517714	187517714	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:187517714C>A	ENST00000441802.2	-	25	13189	c.12980G>T	c.(12979-12981)aGc>aTc	p.S4327I		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4327					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AAAGTCCCAGCTAGGCTTCTG	0.512000										HNSCC(5;0.00058)			15	28					4.7546e-09	7.13813e-09	0.004007	1	0
TPTE2	93492	broad.mit.edu	37	13	20056679	20056679	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:20056679T>G	ENST00000400230.2	-	4	172	c.128A>C	c.(127-129)gAa>gCa	p.E43A	TPTE2_ENST00000457266.2_Missense_Mutation_p.E43A|TPTE2_ENST00000382977.4_Missense_Mutation_p.E43A|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000382975.4_Missense_Mutation_p.E43A|TPTE2_ENST00000400103.2_Missense_Mutation_p.E43A|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000382978.1_Missense_Mutation_p.E43A			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	43						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.E43A(1)		NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GGAAAGTCGTTCTAACATACT	0.313000													3	28					0	0	0.003080	0	0
ADH1A	124	broad.mit.edu	37	4	100208112	100208112	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:100208112G>T	ENST00000209668.2	-	3	267	c.154C>A	c.(154-156)Cac>Aac	p.H52N	ADH1A_ENST00000511656.1_5'UTR|RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	52					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTAACCACGTGGTCATCTGTG	0.473000													29	63					2.65835e-16	4.84078e-16	0.007291	1	0
OR2T33	391195	broad.mit.edu	37	1	248436792	248436792	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248436792C>A	ENST00000318021.2	-	1	346	c.325G>T	c.(325-327)Gag>Tag	p.E109*		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGGAAGCACTCTCCACCACCC	0.587000													9	86					6.90743e-12	1.13626e-11	0.003755	1	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459095	45459095	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:45459095G>T	ENST00000548424.1	+	0	448																											CGCACAAGCTGCTCAAACAGA	0.478000													6	30					6.5536e-12	1.08116e-11	0.003080	1	0
LGR5	8549	broad.mit.edu	37	12	71977430	71977430	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:71977430C>G	ENST00000266674.5	+	18	1951	c.1640C>G	c.(1639-1641)cCc>cGc	p.P547R	LGR5_ENST00000536515.1_Missense_Mutation_p.P475R|LGR5_ENST00000540815.2_Missense_Mutation_p.P523R|RP11-186F10.2_ENST00000546601.1_RNA			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	547						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CTTCTAGGCCCCTTCAAACCC	0.428000													23	81					0	0	0.003330	0	0
MUC16	94025	broad.mit.edu	37	19	9083001	9083001	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9083001C>A	ENST00000397910.4	-	1	9017	c.8814G>T	c.(8812-8814)agG>agT	p.R2938S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2939	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCATCCTTGCCCTTGGGTTTT	0.483000													21	31					1.50039e-11	2.44009e-11	0.012319	1	0
PTPRD	5789	broad.mit.edu	37	9	8521291	8521291	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:8521291T>C	ENST00000381196.4	-	17	1490	c.947A>G	c.(946-948)cAg>cGg	p.Q316R	PTPRD_ENST00000355233.5_Missense_Mutation_p.Q316R|PTPRD_ENST00000358503.5_Missense_Mutation_p.Q303R|PTPRD_ENST00000540109.1_Missense_Mutation_p.Q316R|PTPRD_ENST00000397606.3_Missense_Mutation_p.Q306R|PTPRD_ENST00000537002.1_Missense_Mutation_p.Q313R|PTPRD_ENST00000397611.3_Missense_Mutation_p.Q313R|PTPRD_ENST00000397617.3_Missense_Mutation_p.Q306R|PTPRD_ENST00000360074.4_Missense_Mutation_p.Q303R|PTPRD_ENST00000486161.1_Missense_Mutation_p.Q316R|PTPRD_ENST00000356435.5_Missense_Mutation_p.Q316R	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	316	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACAGTGATCTGTGCTATTGC	0.418000										TSP Lung(15;0.13)			10	41					0	0	0.006214	0	0
MYH3	4621	broad.mit.edu	37	17	10533637	10533637	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:10533637C>A	ENST00000583535.1	-	37	5512	c.5425G>T	c.(5425-5427)Ggg>Tgg	p.G1809W	MYH3_ENST00000226209.7_Missense_Mutation_p.G1809W	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1809					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TGCTTCTTCCCGCCCTTCAGC	0.612000													22	64					1.10923e-09	1.69641e-09	0.002780	1	0
OR6B1	135946	broad.mit.edu	37	7	143701304	143701304	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:143701304G>T	ENST00000408922.2	+	1	283	c.215G>T	c.(214-216)tGg>tTg	p.W72L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TTGGAGACCTGGTACATCTCT	0.448000													23	105					1.96895e-08	2.87076e-08	0.002780	1	0
BRWD3	254065	broad.mit.edu	37	X	79999660	79999660	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:79999660C>A	ENST00000373275.4	-	8	900	c.684G>T	c.(682-684)atG>atT	p.M228I		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	228										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AGTTAACAGCCATGTCAGAAA	0.438000													18	32					1.45105e-14	2.57682e-14	0.006122	1	0
ITGA8	8516	broad.mit.edu	37	10	15617595	15617595	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:15617595T>A	ENST00000378076.3	-	24	2726		c.e24-2			NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TGTGACACTCTGAAACATGAA	0.438000													10	25					0	0	0.006214	0	0
GCM2	9247	broad.mit.edu	37	6	10874559	10874559	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:10874559G>T	ENST00000379491.4	-	5	1337	c.1190C>A	c.(1189-1191)cCt>cAt	p.P397H	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	397					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TTTCATAGCAGGGGGCTGGTA	0.547000													38	91					3.62531e-18	6.75179e-18	0.004289	1	0
LRRC66	339977	broad.mit.edu	37	4	52861910	52861910	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:52861910G>T	ENST00000343457.3	-	4	1284	c.1278C>A	c.(1276-1278)taC>taA	p.Y426*		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	426						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CCATGTCATCGTAGAAGCCCT	0.537000													13	67					4.3838e-07	5.98551e-07	0.001855	1	0
TADA3	10474	broad.mit.edu	37	3	9832953	9832953	+	Silent	SNP	G	G	C	rs139007937		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:9832953G>C	ENST00000343450.2	-	2	745	c.198C>G	c.(196-198)gcC>gcG	p.A66A	TADA3_ENST00000301964.2_Silent_p.A66A|TADA3_ENST00000492635.1_5'UTR|TADA3_ENST00000440161.1_Silent_p.A66A	NM_133480.1	NP_597814.1	O75528	TADA3_HUMAN	transcriptional adaptor 3	66					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	16						CCTGGGTTTCGGCCTCAAGCA	0.592000													7	20					0	0	0.003080	0	0
HIVEP2	3097	broad.mit.edu	37	6	143080981	143080981	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:143080981C>A	ENST00000367603.2	-	9	7186	c.6444G>T	c.(6442-6444)agG>agT	p.R2148S	HIVEP2_ENST00000367604.1_Missense_Mutation_p.R2148S|HIVEP2_ENST00000012134.2_Missense_Mutation_p.R2148S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	2148	10 X 4 AA tandem repeats of S-P-[RGMKC]- [RK].|Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGTATAAAGCCCTTCTGGGAG	0.453000													21	26					5.26018e-13	8.96159e-13	0.012319	1	0
MS4A4A	51338	broad.mit.edu	37	11	60070044	60070044	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:60070044C>A	ENST00000355131.3	+	6	566	c.343C>A	c.(343-345)Cta>Ata	p.L115I	MS4A4A_ENST00000395016.3_Missense_Mutation_p.L115I|MS4A4A_ENST00000532114.1_Intron|MS4A4A_ENST00000337908.4_Missense_Mutation_p.L134I	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	134						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						CCGAGGTAGTCTAGGAATGAA	0.388000													8	44					5.18039e-06	6.69053e-06	0.003080	1	0
EPC2	26122	broad.mit.edu	37	2	149522656	149522656	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:149522656A>C	ENST00000258484.6	+	7	1115	c.1081A>C	c.(1081-1083)Aat>Cat	p.N361H		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	361					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		GCCTGTGATCAATAAGAGTGA	0.363000													5	38					0	0	0.001168	0	0
WIPF1	7456	broad.mit.edu	37	2	175436472	175436472	+	Nonsense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:175436472G>C	ENST00000392547.2	-	5	1160	c.1061C>G	c.(1060-1062)tCa>tGa	p.S354*	AC018890.6_ENST00000412835.1_RNA|WIPF1_ENST00000272746.5_Nonsense_Mutation_p.S354*|WIPF1_ENST00000359761.3_Nonsense_Mutation_p.S354*|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000409891.1_Nonsense_Mutation_p.S354*|WIPF1_ENST00000409415.3_Nonsense_Mutation_p.S354*|WIPF1_ENST00000392546.2_Nonsense_Mutation_p.S354*	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	354	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						AAGAGGACCTGAACGTCCTGG	0.612000													27	117					0	0	0.003954	0	0
IL17A	3605	broad.mit.edu	37	6	52052579	52052579	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:52052579G>T	ENST00000340057.1	+	2	251	c.206G>T	c.(205-207)cGa>cTa	p.R69L		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	69					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					TACTACAACCGATCCACCTCA	0.448000													19	88					4.63292e-17	8.5359e-17	0.008871	1	0
C1orf109	54955	broad.mit.edu	37	1	38155370	38155370	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:38155370C>A	ENST00000358011.4	-	2	372	c.183G>T	c.(181-183)ccG>ccT	p.P61P	C1orf109_ENST00000494120.1_5'UTR	NM_017850.1	NP_060320.1	Q9NX04	CA109_HUMAN	chromosome 1 open reading frame 109	61										lung(2)|prostate(2)	4		Myeloproliferative disorder(586;0.0393)				CCCGAAGCGCCGGCACATCCT	0.627000													15	46					6.31663e-08	9.04103e-08	0.003163	1	0
PDS5B	23047	broad.mit.edu	37	13	33275556	33275556	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:33275556A>G	ENST00000315596.10	+	17	2023	c.1837A>G	c.(1837-1839)Ata>Gta	p.I613V		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	613					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		ACCTGTGCACATAGATACCGA	0.393000													13	6					0	0	0.001855	0	0
PCDH17	27253	broad.mit.edu	37	13	58208942	58208942	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:58208942G>T	ENST00000377918.3	+	1	2288	c.2262G>T	c.(2260-2262)ggG>ggT	p.G754G		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	754					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGCTGGGTGGGGGCAAGGGCA	0.557000													8	30					5.18039e-06	6.69053e-06	0.003080	1	0
ZNF345	25850	broad.mit.edu	37	19	37368191	37368191	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:37368191A>T	ENST00000529555.1	+	2	1247	c.459A>T	c.(457-459)aaA>aaT	p.K153N	ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000420450.1_Missense_Mutation_p.K153N|ZNF345_ENST00000589046.1_Missense_Mutation_p.K153N			Q14585	ZN345_HUMAN	zinc finger protein 345	153					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATGTGGGAAAGCCTTTAGTT	0.423000													7	27					0	0	0.003080	0	0
GPR98	84059	broad.mit.edu	37	5	89933731	89933731	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:89933731G>T	ENST00000405460.2	+	11	2302	c.2206G>T	c.(2206-2208)Gaa>Taa	p.E736*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	736	Calx-beta 5.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGACATACCGGAAATGAATGA	0.353000													8	30					0.00448238	0.00490153	0.004482	1	0
COL5A1	1289	broad.mit.edu	37	9	137660255	137660255	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:137660255G>T	ENST00000371817.3	+	25	2646		c.e25-1			NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1						axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GTTTGTTCTAGGGTCCCTTGG	0.597000													24	45					1.64293e-13	2.82986e-13	0.003330	1	0
MYL2	4633	broad.mit.edu	37	12	111351114	111351114	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:111351114C>T	ENST00000228841.8	-	5	336	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	MYL2_ENST00000548438.1_Missense_Mutation_p.E83K	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	97	EF-hand 2.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						AGAATGGTTTCCTCAGGGTCC	0.587000													15	27					0	0	0.003163	0	0
IFI44	10561	broad.mit.edu	37	1	79116312	79116312	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:79116312G>T	ENST00000370747.4	+	2	517	c.432G>T	c.(430-432)caG>caT	p.Q144H	IFI44_ENST00000495254.1_Intron|IFI44_ENST00000545124.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	144					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						TCTCTATTCAGGATTATGAAG	0.338000													10	29					7.48243e-07	1.01278e-06	0.006214	1	0
UNC79	57578	broad.mit.edu	37	14	94007138	94007138	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:94007138C>A	ENST00000553484.1	+	13	1639	c.1485C>A	c.(1483-1485)caC>caA	p.H495Q	UNC79_ENST00000555664.1_Missense_Mutation_p.H495Q|UNC79_ENST00000393151.2_Missense_Mutation_p.H495Q|UNC79_ENST00000256339.4_Missense_Mutation_p.H318Q			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	495						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATGATAAACACGATCAGAGGC	0.433000													26	40					2.41591e-17	4.45596e-17	0.004656	1	0
PMEL	6490	broad.mit.edu	37	12	56351763	56351763	+	Missense_Mutation	SNP	C	C	A	rs145035997		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:56351763C>A	ENST00000548747.1	-	5	1237	c.575G>T	c.(574-576)cGg>cTg	p.R192L	PMEL_ENST00000548689.1_5'UTR|PMEL_ENST00000550447.1_Intron|PMEL_ENST00000539511.1_Missense_Mutation_p.R106L|PMEL_ENST00000550464.1_Missense_Mutation_p.R106L|PMEL_ENST00000536427.1_Missense_Mutation_p.R192L|PMEL_ENST00000360714.4_Missense_Mutation_p.R192L|PMEL_ENST00000548493.1_Missense_Mutation_p.R192L|PMEL_ENST00000449260.2_Missense_Mutation_p.R192L|PMEL_ENST00000552882.1_Missense_Mutation_p.R192L			P40967	PMEL_HUMAN	premelanosome protein	192					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCGGGATCCCCGGCGATGGTA	0.567000													22	33					1.50039e-11	2.44009e-11	0.012319	1	0
MRGPRX1	259249	broad.mit.edu	37	11	18955702	18955702	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:18955702C>A	ENST00000302797.3	-	1	854	c.630G>T	c.(628-630)ccG>ccT	p.P210P	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	210					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCCTGGTCAGCGGTATCTTCC	0.507000													6	18					0.00116845	0.00130426	0.001168	1	0
SERPINB12	89777	broad.mit.edu	37	18	61232706	61232706	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:61232706C>A	ENST00000382768.1	+	6	734	c.734C>A	c.(733-735)aCg>aAg	p.T245K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.T225K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	225					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity	p.T225M(1)		kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						AAGATGATGACGCAAAAAGGC	0.488000													12	58					3.07112e-06	4.01769e-06	0.010729	1	0
FLG	2312	broad.mit.edu	37	1	152275457	152275457	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152275457G>T	ENST00000368799.1	-	3	11940	c.11905C>A	c.(11905-11907)Caa>Aaa	p.Q3969K	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3969					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAACCTGATTGACCTTTTTGC	0.428000									Ichthyosis				36	35					2.19358e-23	4.28983e-23	0.005524	1	0
RIMS2	9699	broad.mit.edu	37	8	105161047	105161047	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:105161047G>T	ENST00000436393.2	+	23	3600	c.3359G>T	c.(3358-3360)aGt>aTt	p.S1120I	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1159					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCACGGAAAAGTCGCAGTGCT	0.453000										HNSCC(12;0.0054)			31	40					9.93527e-08	1.41497e-07	0.002836	1	0
SLITRK6	84189	broad.mit.edu	37	13	86370512	86370512	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:86370512C>A	ENST00000400286.2	-	2	730	c.132G>T	c.(130-132)atG>atT	p.M44I		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	44	LRRNT 1.					integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AATTTATTAGCATTGTGCCAT	0.408000													9	29					1.76689e-08	2.57834e-08	0.006214	1	0
SGMS2	166929	broad.mit.edu	37	4	108817003	108817003	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:108817003A>T	ENST00000394684.4	+	3	851	c.294A>T	c.(292-294)acA>acT	p.T98T	SGMS2_ENST00000359079.4_Silent_p.T98T|RP11-286E11.1_ENST00000499098.1_RNA|RP11-286E11.1_ENST00000513071.1_RNA|SGMS2_ENST00000394686.3_Silent_p.T98T	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	98					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TCATGATCACAGTTGTACATG	0.448000													15	35					0	0	0.003163	0	0
GPR85	54329	broad.mit.edu	37	7	112724719	112724719	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:112724719C>A	ENST00000501255.2	-	3	681	c.58G>T	c.(58-60)Gcc>Tcc	p.A20S	GPR85_ENST00000424100.1_Missense_Mutation_p.A20S|GPR85_ENST00000297146.2_Missense_Mutation_p.A20S|GPR85_ENST00000449591.1_Missense_Mutation_p.A20S	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	20						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						TTCAGAAAGGCTGTTAGAGGC	0.453000													12	45					0.00136819	0.00152426	0.001368	1	0
ESRRB	2103	broad.mit.edu	37	14	76966235	76966235	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:76966235C>T	ENST00000380887.2	+	8	1398	c.1326C>T	c.(1324-1326)ccC>ccT	p.P442P	ESRRB_ENST00000509242.1_Silent_p.P442P|ESRRB_ENST00000261532.7_3'UTR|RP11-187O7.3_ENST00000554926.1_lincRNA			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	442						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GAGGATCTCCCAAGGATGAAA	0.517000													15	24					0	0	0.002450	0	0
AKR1B10	57016	broad.mit.edu	37	7	134215442	134215442	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:134215442A>G	ENST00000359579.4	+	2	434	c.114A>G	c.(112-114)gcA>gcG	p.A38A	AKR1B10_ENST00000475559.1_3'UTR	NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	38					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						CCATTGATGCAGGATATCGGC	0.458000													15	106					0	0	0.003163	0	0
SCN2A	6326	broad.mit.edu	37	2	166245987	166245987	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:166245987G>A	ENST00000375437.2	+	27	5961	c.5671G>A	c.(5671-5673)Gtc>Atc	p.V1891I	SCN2A_ENST00000283256.6_Missense_Mutation_p.V1891I|SCN2A_ENST00000357398.3_Missense_Mutation_p.V1891I|SCN2A_ENST00000375427.2_Missense_Mutation_p.V1891I	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1891					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CCCCTCCAAAGTCTCTTATGA	0.453000													12	49					0	0	0.010729	0	0
RNASE4	6038	broad.mit.edu	37	14	21167586	21167586	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:21167586G>A	ENST00000555835.1	+	2	732	c.56G>A	c.(55-57)gGg>gAg	p.G19E	RP11-903H12.3_ENST00000554286.1_lincRNA|AL163636.6_ENST00000553909.1_RNA|RNASE4_ENST00000555597.1_Missense_Mutation_p.G19E|RNASE4_ENST00000397995.2_Missense_Mutation_p.G19E|RNASE4_ENST00000304704.4_Missense_Mutation_p.G19E	NM_002937.3	NP_002928.1	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4	19					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		ACCCTGCTGGGGCTGGGGCTG	0.572000													24	81					0	0	0.005443	0	0
OR6M1	390261	broad.mit.edu	37	11	123676174	123676174	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:123676174T>A	ENST00000309154.2	-	1	921	c.884A>T	c.(883-885)cAg>cTg	p.Q295L		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CAACACTTCCTGTACCTTCTC	0.408000													6	44					0	0	0.001984	0	0
CDH2	1000	broad.mit.edu	37	18	25565563	25565563	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:25565563C>A	ENST00000269141.3	-	12	2327	c.1904G>T	c.(1903-1905)gGa>gTa	p.G635V	CDH2_ENST00000399380.3_Missense_Mutation_p.G604V	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	635	Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AGCAAATGGTCCAGCATTTGG	0.383000													8	45					1.12685e-05	1.4264e-05	0.004482	1	0
TRBV6-8	28599	broad.mit.edu	37	7	142124152	142124152	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:142124152C>T	ENST00000390376.2	-	0	325																											ACTGCTGGCACACAAGTACAC	0.547000													123	299					0	0	0.003610	0	0
VPS16	64601	broad.mit.edu	37	20	2846072	2846072	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:2846072G>T	ENST00000380445.3	+	22	2274	c.2202G>T	c.(2200-2202)ctG>ctT	p.L734L	VPS16_ENST00000380469.3_Silent_p.L590L|VPS16_ENST00000380443.3_Silent_p.L420L|PTPRA_ENST00000380393.3_Intron	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	734					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						TGACTGCCCTGGCAGATTTGG	0.587000													4	19					0.000602214	0.000681505	0.000602	1	0
BUD13	84811	broad.mit.edu	37	11	116633838	116633838	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:116633838C>G	ENST00000260210.4	-	4	490	c.467G>C	c.(466-468)cGt>cCt	p.R156P	BUD13_ENST00000375445.3_Missense_Mutation_p.R156P	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	156	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGTGTCATGACGGGCCCTCCT	0.592000													31	98					0	0	0.009535	0	0
SLC22A8	9376	broad.mit.edu	37	11	62766429	62766429	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:62766429A>T	ENST00000336232.2	-	5	860	c.725T>A	c.(724-726)gTg>gAg	p.V242E	SLC22A8_ENST00000545207.1_Missense_Mutation_p.V151E|SLC22A8_ENST00000311438.8_Missense_Mutation_p.V242E|SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000430500.2_Missense_Mutation_p.V242E|SLC22A8_ENST00000535878.1_Missense_Mutation_p.V119E	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	242					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GGGAATGGACACAGTTAACTG	0.562000													10	51					0	0	0.006214	0	0
SLC14A2	8170	broad.mit.edu	37	18	43224063	43224063	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:43224063C>A	ENST00000255226.6	+	10	2105	c.1289C>A	c.(1288-1290)cCc>cAc	p.P430H	SLC14A2_ENST00000586448.1_Missense_Mutation_p.P430H	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	430						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTCACCTACCCCGAGGCCAAC	0.562000													26	108					1.16021e-09	1.7728e-09	0.007291	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178580565	178580565	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:178580565A>G	ENST00000251582.7	-	9	1543	c.1442T>C	c.(1441-1443)cTc>cCc	p.L481P	ADAMTS2_ENST00000274609.5_Missense_Mutation_p.L481P	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	481	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGTCCCGGGAGCTGGGGCAG	0.667000													4	17					0	0	0.009096	0	0
COQ9	57017	broad.mit.edu	37	16	57486804	57486804	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:57486804C>T	ENST00000262507.6	+	3	403	c.334C>T	c.(334-336)Ccc>Tcc	p.P112S	COQ9_ENST00000567072.1_Missense_Mutation_p.P112S|COQ9_ENST00000567933.1_Missense_Mutation_p.P112S	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	112					ubiquinone biosynthetic process	mitochondrion		p.P112S(2)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						TGAGTTTGTGCCCGCCCACGG	0.592000													4	87					0	0	0.000602	0	0
KIF26B	55083	broad.mit.edu	37	1	245582880	245582880	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:245582880G>T	ENST00000407071.2	+	4	1439		c.e4-1			NM_018012.3	NP_060482.2	Q2KJY2	KI26B_HUMAN	kinesin family member 26B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TTCTTTGTCAGATCTCCCAGC	0.537000													11	24					0.000673444	0.000759613	0.008291	1	0
DBH	1621	broad.mit.edu	37	9	136501680	136501680	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:136501680T>C	ENST00000393056.2	+	1	199	c.187T>C	c.(187-189)Tgg>Cgg	p.W63R		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	63	DOMON.				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GGAGCTCTCATGGAATGTCAG	0.652000													3	14					0	0	0.009096	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708782	36708782	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:36708782T>A	ENST00000264659.7	-	13	2605	c.2381A>T	c.(2380-2382)gAg>gTg	p.E794V	SRCIN1_ENST00000398579.4_5'UTR|SRCIN1_ENST00000578925.1_Missense_Mutation_p.E828V	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	666					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						CGCCTCCACCTCCACGCGCAG	0.672000													3	14					0	0	0.004672	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183248	39183248	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:39183248C>A	ENST00000361883.5	-	1	206	c.160G>T	c.(160-162)Ggg>Tgg	p.G54W		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	54	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament				central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CTGCAGGTCCCACTGGTTGAG	0.627000													11	80					6.40141e-05	7.73298e-05	0.010729	1	0
FLG	2312	broad.mit.edu	37	1	152284273	152284273	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152284273C>G	ENST00000368799.1	-	3	3124	c.3089G>C	c.(3088-3090)gGa>gCa	p.G1030A	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1030	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTCTTTCTCCTGGACTTGA	0.562000									Ichthyosis				263	319					0	0	0.003610	0	0
BSN	8927	broad.mit.edu	37	3	49690234	49690234	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:49690234G>A	ENST00000296452.4	+	5	3359	c.3245G>A	c.(3244-3246)cGg>cAg	p.R1082Q		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1082					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GAAGAACTGCGGGCCCAGCGG	0.657000													5	40					0	0	0.000602	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39190682	39190682	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:39190682G>T	ENST00000344363.5	-	1	425	c.392C>A	c.(391-393)cCa>cAa	p.P131Q		NM_030966.1	NP_112228.1	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	141						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCAGGTTGGGGGTGTGCA	0.667000													4	59					0.00909568	0.00969341	0.009096	1	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874330	74874330	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:74874330G>T	ENST00000331628.3	-	4	872	c.625C>A	c.(625-627)Cta>Ata	p.L209I	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.L209I	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	209					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						AGTGTGGCTAGGAAGAGGGCC	0.622000													36	56					1.836e-18	3.43426e-18	0.003755	1	0
MYO7B	4648	broad.mit.edu	37	2	128335809	128335809	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:128335809C>A	ENST00000389524.4	+	9	1004	c.951C>A	c.(949-951)gaC>gaA	p.D317E	MYO7B_ENST00000409816.2_Missense_Mutation_p.D317E|MYO7B_ENST00000428314.1_Missense_Mutation_p.D317E			Q6PIF6	MYO7B_HUMAN	myosin VIIB	317	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity	p.D317D(2)		breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGAGCTGGGACGTCATCAAGC	0.607000													6	33					3.59834e-05	4.44363e-05	0.001168	1	0
DNAH5	1767	broad.mit.edu	37	5	13752338	13752338	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:13752338T>C	ENST00000265104.4	-	64	11037	c.10933A>G	c.(10933-10935)Agg>Ggg	p.R3645G		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3645	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGCAAAGGCCTTCCAAGAGAA	0.408000									Kartagener syndrome				14	143					0	0	0.004007	0	0
CYB5R4	51167	broad.mit.edu	37	6	84634200	84634200	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:84634200G>C	ENST00000369681.4	+	10	843	c.703G>C	c.(703-705)Gag>Cag	p.E235Q		NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	235	CS.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		GCGGGTTGTTGAGAGTGTGGG	0.328000													9	34					0	0	0.006214	0	0
N4BP2	55728	broad.mit.edu	37	4	40104284	40104284	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:40104284G>T	ENST00000261435.6	+	4	1235	c.819G>T	c.(817-819)gaG>gaT	p.E273D		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	273						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TAGAATCTGAGTGCGTTGAGG	0.433000													21	36					2.37509e-13	4.0787e-13	0.010504	1	0
CDH16	1014	broad.mit.edu	37	16	66949151	66949151	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:66949151C>G	ENST00000299752.4	-	6	748	c.555G>C	c.(553-555)cgG>cgC	p.R185R	CDH16_ENST00000570262.1_Silent_p.R105R|CDH16_ENST00000394055.3_Silent_p.R185R|CDH16_ENST00000565796.1_Silent_p.R185R|CDH16_ENST00000568632.1_Intron	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	185	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GAGCCCCCAGCCGAGGCTCCA	0.627000													11	41					0	0	0.008291	0	0
ITGA4	3676	broad.mit.edu	37	2	182322569	182322569	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:182322569C>T	ENST00000397033.2	+	1	618	c.188C>T	c.(187-189)gCg>gTg	p.A63V	ITGA4_ENST00000339307.4_Missense_Mutation_p.A63V	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	63					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AGCCACGGGGCGAACCGATGG	0.627000													4	12					0	0	0.009096	0	0
CYP27C1	339761	broad.mit.edu	37	2	127957001	127957001	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:127957001T>C	ENST00000335247.7	-	4	633	c.503A>G	c.(502-504)cAg>cGg	p.Q168R	CYP27C1_ENST00000409327.1_Missense_Mutation_p.Q168R	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	168						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GTAGATCTCCTGCAGCGTCAG	0.577000													31	54					0	0	0.009535	0	0
MISP	126353	broad.mit.edu	37	19	757678	757678	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:757678G>T	ENST00000215582.6	+	2	835	c.732G>T	c.(730-732)gtG>gtT	p.V244V		NM_173481.2	NP_775752.1			mitotic spindle positioning																		ACGGGCACGTGGTTCCCATCA	0.662000													9	7					2.17888e-05	2.72201e-05	0.006214	1	0
GPATCH4	54865	broad.mit.edu	37	1	156565192	156565192	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:156565192C>T	ENST00000368232.4	-	8	1058	c.926G>A	c.(925-927)gGa>gAa	p.G309E	GPATCH4_ENST00000438976.2_Missense_Mutation_p.G314E	NM_015590.3|NM_182679.2	NP_056405.2|NP_872620.1	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4	309						intracellular	nucleic acid binding	p.G309E(1)		autonomic_ganglia(1)|breast(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(3)|stomach(1)	17	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCTTTTCCTCCTTCCTCCAA	0.522000													42	116					0	0	0.007835	0	0
PVRL4	81607	broad.mit.edu	37	1	161044151	161044151	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:161044151T>A	ENST00000368012.3	-	6	1315	c.1013A>T	c.(1012-1014)gAc>gTc	p.D338V	PVRL4_ENST00000453926.2_Missense_Mutation_p.D72V	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	338					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTTCCCAGAGTCTTCCTGGGG	0.602000													10	36					0	0	0.008291	0	0
OR52M1	119772	broad.mit.edu	37	11	4566790	4566790	+	Missense_Mutation	SNP	C	C	G	rs61751908	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:4566790C>G	ENST00000360213.1	+	1	370	c.370C>G	c.(370-372)Cgc>Ggc	p.R124G		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCTTTTGATCGCTACGTGGC	0.527000													15	28					0	0	0.002450	0	0
RLN2	6019	broad.mit.edu	37	9	5300235	5300235	+	Missense_Mutation	SNP	C	C	A	rs61738985	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:5300235C>A	ENST00000381627.3	-	2	809	c.421G>T	c.(421-423)Gca>Tca	p.A141S	RLN2_ENST00000308420.3_3'UTR	NM_134441.2	NP_604390.1	P04090	REL2_HUMAN	relaxin 2	141					female pregnancy	extracellular region	hormone activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	11	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTGCTGTCTGCGGCTTCACTT	0.368000													13	80					7.03913e-09	1.04583e-08	0.001368	1	0
ZNF274	10782	broad.mit.edu	37	19	58724056	58724056	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:58724056G>T	ENST00000326804.4	+	9	1965	c.1506G>T	c.(1504-1506)ggG>ggT	p.G502G	ZNF274_ENST00000345813.3_Silent_p.G470G|ZNF274_ENST00000424679.2_Silent_p.G397G|ZNF274_ENST00000597818.1_3'UTR	NM_133502.1	NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	503					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		TTCACAAGGGGAGCCAAGTTT	0.433000													26	53					7.88262e-20	1.50058e-19	0.003330	1	0
MALT1	10892	broad.mit.edu	37	18	56409154	56409154	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:56409154T>C	ENST00000348428.3	+	14	1919	c.1661T>C	c.(1660-1662)tTa>tCa	p.L554S	MALT1_ENST00000345724.3_Missense_Mutation_p.L543S|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	554	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						CGAAGTAGTTTATCTGAGAAG	0.388000			T	BIRC3	MALT								11	48					0	0	0.001368	0	0
DOCK1	1793	broad.mit.edu	37	10	129207637	129207637	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:129207637T>G	ENST00000280333.6	+	42	4371	c.4262T>G	c.(4261-4263)gTg>gGg	p.V1421G		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1421	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CACAGGCCAGTGTCAGAGCAG	0.443000													14	49					0	0	0.004990	0	0
ZFHX3	463	broad.mit.edu	37	16	72993483	72993483	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:72993483C>A	ENST00000268489.5	-	2	1234	c.562G>T	c.(562-564)Gca>Tca	p.A188S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	188					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TACACGGGTGCAGCACACGAA	0.617000													23	57					2.89027e-11	4.66514e-11	0.002299	1	0
PDSS2	57107	broad.mit.edu	37	6	107595379	107595379	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:107595379G>A	ENST00000369037.4	-	3	761	c.484C>T	c.(484-486)Cat>Tat	p.H162Y	PDSS2_ENST00000453874.2_Missense_Mutation_p.H162Y|PDSS2_ENST00000369031.4_Missense_Mutation_p.H162Y	NM_020381.3	NP_065114.3	Q86YH6	DLP1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 2	162					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)	19	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		ATCCCACGATGTACAAGGAGA	0.348000													11	21					0	0	0.008291	0	0
MMP2	4313	broad.mit.edu	37	16	55532201	55532201	+	Splice_Site	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:55532201G>C	ENST00000219070.4	+	11	2119	c.1609_splice	c.e11-1	p.G537_splice	MMP2_ENST00000570308.1_Splice_Site_p.G461_splice|MMP2_ENST00000543485.1_Splice_Site_p.G461_splice|MMP2_ENST00000437642.2_Splice_Site_p.G487_splice	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	537	Hemopexin-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TCCACCCCAGGGAATGAATAC	0.612000													12	32					0	0	0.002450	0	0
IFI16	3428	broad.mit.edu	37	1	158990202	158990202	+	Silent	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:158990202A>C	ENST00000295809.7	+	6	1299	c.1044A>C	c.(1042-1044)acA>acC	p.T348T	IFI16_ENST00000368131.4_Silent_p.T348T|IFI16_ENST00000368132.3_Silent_p.T348T|IFI16_ENST00000359709.3_Silent_p.T292T|IFI16_ENST00000430894.2_Silent_p.T296T|IFI16_ENST00000340979.6_Silent_p.T348T|IFI16_ENST00000448393.2_Silent_p.T348T			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	348	HIN-200 1.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					TAGTGGGGACAGGACAATGTC	0.363000													10	31					0	0	0.008291	0	0
SLC9B1	150159	broad.mit.edu	37	4	103866435	103866435	+	Missense_Mutation	SNP	C	C	A	rs4504256		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:103866435C>A	ENST00000296422.7	-	6	709	c.568G>T	c.(568-570)Ggt>Tgt	p.G190C	SLC9B1_ENST00000394789.3_Missense_Mutation_p.G190C	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	190						integral to membrane	solute:hydrogen antiporter activity										AGGCATGGACCTACAGCCAAT	0.388000													28	81					9.39395e-14	1.62784e-13	0.006320	1	0
RB1CC1	9821	broad.mit.edu	37	8	53555277	53555277	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:53555277T>C	ENST00000025008.5	-	17	4606	c.4083A>G	c.(4081-4083)caA>caG	p.Q1361Q	RB1CC1_ENST00000435644.2_Silent_p.Q1361Q|RB1CC1_ENST00000539297.1_Silent_p.Q1361Q|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1361					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TATCCCGTTCTTGTTGCTGCA	0.274000													12	18					0	0	0.001368	0	0
PLA2G7	7941	broad.mit.edu	37	6	46672424	46672424	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:46672424T>G	ENST00000274793.7	-	12	1395	c.1199A>C	c.(1198-1200)aAa>aCa	p.K400T	PLA2G7_ENST00000537365.1_Missense_Mutation_p.K400T	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	400					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			ATCAAAATCTTTATGAAGTCC	0.338000													4	25					0	0	0.001168	0	0
PCDH15	65217	broad.mit.edu	37	10	55780158	55780158	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:55780158C>T	ENST00000373965.2	-	21	2960	c.2566G>A	c.(2566-2568)Gga>Aga	p.G856R	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.G849R|PCDH15_ENST00000395445.1_Missense_Mutation_p.G856R|PCDH15_ENST00000437009.1_Missense_Mutation_p.G778R|PCDH15_ENST00000409834.1_Missense_Mutation_p.G460R|PCDH15_ENST00000395438.1_Missense_Mutation_p.G849R|PCDH15_ENST00000395432.2_Missense_Mutation_p.G812R|PCDH15_ENST00000414778.1_Missense_Mutation_p.G854R|PCDH15_ENST00000320301.6_Missense_Mutation_p.G849R|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.G827R|PCDH15_ENST00000395430.1_Missense_Mutation_p.G849R|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.G849R	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	849	Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATTTGCTCCAAGGTCGACA	0.388000										HNSCC(58;0.16)			17	81					0	0	0.006122	0	0
COL5A3	50509	broad.mit.edu	37	19	10107362	10107362	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:10107362G>A	ENST00000264828.3	-	12	1352	c.1267C>T	c.(1267-1269)Cct>Tct	p.P423S	CTD-2553C6.1_ENST00000592332.1_RNA	NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	423	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGGCCAGCAGGGCCCTgagag	0.607000													4	7					0	0	0.009096	0	0
FLG	2312	broad.mit.edu	37	1	152275775	152275775	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152275775C>A	ENST00000368799.1	-	3	11622	c.11587G>T	c.(11587-11589)Gtt>Ttt	p.V3863F	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3863	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGGCTAACACTGGATCCC	0.567000									Ichthyosis				31	209					1.39806e-14	2.48784e-14	0.008361	1	0
LPPR4	9890	broad.mit.edu	37	1	99771527	99771527	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:99771527C>A	ENST00000370185.3	+	7	1750	c.1253C>A	c.(1252-1254)cCg>cAg	p.P418Q	LPPR4_ENST00000457765.1_Missense_Mutation_p.P360Q|LPPR4_ENST00000370184.1_Missense_Mutation_p.P260Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		418							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AATACCTTGCCGCGAGCCAAT	0.498000													15	29					6.72482e-11	1.07037e-10	0.003163	1	0
USH2A	7399	broad.mit.edu	37	1	215847454	215847454	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:215847454T>A	ENST00000366943.2	-	63	14185	c.13799A>T	c.(13798-13800)aAg>aTg	p.K4600M	USH2A_ENST00000307340.3_Missense_Mutation_p.K4600M			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4600	Fibronectin type-III 31.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGAAATGGCTTCAGCTGGTT	0.398000										HNSCC(13;0.011)			19	48					0	0	0.008871	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999226	143999226	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:143999226C>T	ENST00000323110.2	-	1	33	c.31G>A	c.(31-33)Gtg>Atg	p.V11M		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	11					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCGCTGCCACGCACACCTCT	0.612000									Familial Hyperaldosteronism type I				50	59					0	0	0.003610	0	0
CDH2	1000	broad.mit.edu	37	18	25565564	25565564	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:25565564C>A	ENST00000269141.3	-	12	2326	c.1903G>T	c.(1903-1905)Gga>Tga	p.G635*	CDH2_ENST00000399380.3_Nonsense_Mutation_p.G604*	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	635	Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GCAAATGGTCCAGCATTTGGA	0.383000													11	41					1.08611e-07	1.52534e-07	0.010729	1	0
FBN2	2201	broad.mit.edu	37	5	127637170	127637170	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:127637170C>G	ENST00000508053.1	-	53	6924	c.5950G>C	c.(5950-5952)Gtg>Ctg	p.V1984L	FBN2_ENST00000262464.4_Missense_Mutation_p.V1984L			P35556	FBN2_HUMAN	fibrillin 2	1984	EGF-like 33; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTCTGCACACCTGACCAAAA	0.368000													17	18					0	0	0.010504	0	0
NEK3	4752	broad.mit.edu	37	13	52710340	52710340	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:52710340C>T	ENST00000452082.2	-	11	2328	c.1098G>A	c.(1096-1098)caG>caA	p.Q366Q	NEK3_ENST00000339406.3_Silent_p.Q362Q|NEK3_ENST00000400357.2_Silent_p.Q345Q|NEK3_ENST00000378101.2_Silent_p.Q362Q			P51956	NEK3_HUMAN	NIMA-related kinase 3	362					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		TTTTCTCCCACTGTCGTCTAT	0.403000													14	44					0	0	0.003163	0	0
DPY19L2	283417	broad.mit.edu	37	12	63987882	63987882	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:63987882G>C	ENST00000324472.4	-	16	1748	c.1565C>G	c.(1564-1566)aCa>aGa	p.T522R		NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	522					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATAAATGTTTGTAGCTAAAAC	0.239000													12	14					0	0	0.001855	0	0
USH2A	7399	broad.mit.edu	37	1	216498711	216498711	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:216498711G>T	ENST00000366943.2	-	6	1465	c.1079C>A	c.(1078-1080)aCa>aAa	p.T360K	USH2A_ENST00000307340.3_Missense_Mutation_p.T360K|USH2A_ENST00000366942.3_Missense_Mutation_p.T360K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	360	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTAATGTTTGTAAACACATT	0.368000										HNSCC(13;0.011)			8	56					0.000157383	0.000184418	0.003080	1	0
TPK1	27010	broad.mit.edu	37	7	144345917	144345917	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:144345917C>G	ENST00000360057.3	-	5	343	c.241G>C	c.(241-243)Gaa>Caa	p.E81Q	TPK1_ENST00000547966.1_5'UTR|TPK1_ENST00000538212.2_Missense_Mutation_p.E76Q|TPK1_ENST00000378099.3_Missense_Mutation_p.E81Q|TPK1_ENST00000549981.1_5'UTR	NM_022445.3	NP_071890.2	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	81					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	GCATAGTATTCTCTGACTTCA	0.308000													15	128					0	0	0.003163	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714288	74714288	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:74714288A>G	ENST00000373032.3	-	1	248	c.156T>C	c.(154-156)tcT>tcC	p.S52S		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	52					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					GCTCCAGAAAAGAATCGAAGT	0.532000													34	196					0	0	0.003271	0	0
SI	6476	broad.mit.edu	37	3	164724632	164724632	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:164724632C>A	ENST00000264382.3	-	37	4440	c.4378G>T	c.(4378-4380)Gga>Tga	p.G1460*		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1460	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTGACCATCCATAGAGATTG	0.343000										HNSCC(35;0.089)			3	15					6.4e-05	7.73298e-05	0.004672	1	0
CHMP6	79643	broad.mit.edu	37	17	78968447	78968447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:78968447G>T	ENST00000325167.5	+	2	208	c.130G>T	c.(130-132)Gag>Tag	p.E44*		NM_024591.4	NP_078867.2	Q96FZ7	CHMP6_HUMAN	charged multivesicular body protein 6	44					cellular membrane organization|endosome transport|protein transport	cytosol|endomembrane system|late endosome membrane	protein N-terminus binding			lung(2)|ovary(1)	3	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0175)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCTGGAGCGCGAGCGCGCCCT	0.716000													7	8					2.7689e-08	4.02685e-08	0.001984	1	0
ASXL3	80816	broad.mit.edu	37	18	31325106	31325106	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:31325106C>A	ENST00000269197.5	+	12	5294	c.5294C>A	c.(5293-5295)cCa>cAa	p.P1765Q		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1765					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AAAGTGTTGCCACAGCCCAGA	0.512000													9	20					5.4927e-09	8.18194e-09	0.004482	1	0
CSMD2	114784	broad.mit.edu	37	1	34238303	34238303	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:34238303C>G	ENST00000373381.4	-	13	1889	c.1713G>C	c.(1711-1713)cgG>cgC	p.R571R	CSMD2_ENST00000338325.1_Silent_p.R179R	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	531	Sushi 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGCCTTCCCTCCGGCCATATG	0.522000													11	61					0	0	0.008291	0	0
SPAST	6683	broad.mit.edu	37	2	32361981	32361981	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:32361981G>T	ENST00000315285.3	+	11	1482	c.1357G>T	c.(1357-1359)Ggg>Tgg	p.G453W	SPAST_ENST00000345662.1_Missense_Mutation_p.G421W	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	453	Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAGAAGAGAAGGGGAGCACGA	0.333000													6	16					0.00307968	0.00338706	0.003080	1	0
PER2	8864	broad.mit.edu	37	2	239161571	239161571	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:239161571C>T	ENST00000254657.3	-	19	3372	c.3093G>A	c.(3091-3093)caG>caA	p.Q1031Q	AC096574.4_ENST00000456601.1_RNA|PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	1031					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GCGCCTTCGGCTGCTGGTCCC	0.617000													8	83					0	0	0.003080	0	0
PIEZO2	63895	broad.mit.edu	37	18	10681675	10681675	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:10681675C>A	ENST00000302079.6	-	46	7233	c.7234G>T	c.(7234-7236)Gct>Tct	p.A2412S	PIEZO2_ENST00000285141.4_Missense_Mutation_p.A267S|PIEZO2_ENST00000503781.3_Missense_Mutation_p.A2475S|PIEZO2_ENST00000580640.1_Missense_Mutation_p.A2500S|PIEZO2_ENST00000538948.1_Missense_Mutation_p.A432S			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2475						integral to membrane	ion channel activity										CTAGAAAAAGCTTGTATAAAT	0.393000													10	42					7.48243e-07	1.01278e-06	0.006214	1	0
TRPC4	7223	broad.mit.edu	37	13	38237773	38237773	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:38237773G>T	ENST00000379705.3	-	6	2325	c.1468C>A	c.(1468-1470)Ctg>Atg	p.L490M	TRPC4_ENST00000379681.3_Missense_Mutation_p.L490M|TRPC4_ENST00000338947.5_Missense_Mutation_p.L317M|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000358477.2_Missense_Mutation_p.L490M|TRPC4_ENST00000447043.1_Missense_Mutation_p.L490M|TRPC4_ENST00000355779.2_Missense_Mutation_p.L490M|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000379673.2_Missense_Mutation_p.L490M|TRPC4_ENST00000379679.1_Missense_Mutation_p.L317M			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	490					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATCAGACGCAGAGAACTGAAG	0.438000													4	31					0.00909568	0.00969341	0.009096	1	0
PLXNA4	91584	broad.mit.edu	37	7	132193255	132193255	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:132193255C>A	ENST00000359827.3	-	2	1160	c.198G>T	c.(196-198)ggG>ggT	p.G66G	PLXNA4_ENST00000321063.4_Silent_p.G66G|PLXNA4_ENST00000423507.2_Silent_p.G66G|PLXNA4_ENST00000378539.5_Silent_p.G66G			Q9HCM2	PLXA4_HUMAN	plexin A4	66	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GATTGACGGCCCCCAAGTAAA	0.572000													34	51					9.8876e-21	1.89485e-20	0.004878	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3687105	3687105	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:3687105G>T	ENST00000344754.4	-	2	297	c.298C>A	c.(298-300)Ctg>Atg	p.L100M	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.L100M	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	100	Ig-like V-type.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TTCAGCAGCAGGTTGCACACC	0.637000													12	44					5.50884e-06	7.0564e-06	0.001368	1	0
TOR1AIP1	26092	broad.mit.edu	37	1	179870504	179870504	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:179870504G>T	ENST00000435319.3	+	5	911	c.720G>T	c.(718-720)agG>agT	p.R240S	TOR1AIP1_ENST00000474875.1_3'UTR|TOR1AIP1_ENST00000271583.3_Missense_Mutation_p.R241S	NM_001267578.1|NM_015602.3	NP_001254507.1|NP_056417.2	Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1	240						integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						CCAGATCCAGGGATTCTGATG	0.338000													5	24					0.000602214	0.000681505	0.000602	1	0
PYDC2	152138	broad.mit.edu	37	3	191179241	191179241	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:191179241C>A	ENST00000518817.1	+	1	290	c.290C>A	c.(289-291)cCt>cAt	p.P97H		NM_001083308.1	NP_001076777.1	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	97						cytoplasm|nucleus				breast(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	10						ATGCCCCCACCTTAACCCCTC	0.483000													16	64					5.3912e-06	6.94714e-06	0.006122	1	0
MMRN1	22915	broad.mit.edu	37	4	90816678	90816678	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:90816678C>A	ENST00000394980.1	+	2	875	c.556C>A	c.(556-558)Cgg>Agg	p.R186R	MMRN1_ENST00000394981.1_Silent_p.R152R|MMRN1_ENST00000264790.2_Silent_p.R186R			Q13201	MMRN1_HUMAN	multimerin 1	186					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATACCTCAGCCGGGGTGACAG	0.473000													8	27					1.06961e-07	1.51455e-07	0.003080	1	0
UBE2D1	7321	broad.mit.edu	37	10	60124613	60124613	+	Nonsense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:60124613C>G	ENST00000373910.4	+	5	508	c.281C>G	c.(280-282)tCa>tGa	p.S94*		NM_001204880.1|NM_003338.4	NP_001191809.1|NP_003329.1	P51668	UB2D1_HUMAN	ubiquitin-conjugating enzyme E2D 1	94					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|BMP signaling pathway|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K48-linked ubiquitination|transforming growth factor beta receptor signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|prostate(1)|skin(2)	10						TCACAATGGTCACCAGCTCTG	0.338000													8	34					0	0	0.006214	0	0
PIK3R5	23533	broad.mit.edu	37	17	8785176	8785176	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:8785176C>T	ENST00000447110.1	-	16	2352	c.2228G>A	c.(2227-2229)cGc>cAc	p.R743H	PIK3R5_ENST00000581552.1_Missense_Mutation_p.R743H|PIK3R5_ENST00000584803.1_Missense_Mutation_p.R742H	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	743	Interaction with G beta gamma proteins (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GTTGCTCCAGCGACTTCGTCC	0.612000													3	10					0	0	0.004672	0	0
SIM1	6492	broad.mit.edu	37	6	100838856	100838856	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:100838856G>T	ENST00000369208.3	-	12	2464	c.1682C>A	c.(1681-1683)cCc>cAc	p.P561H	SIM1_ENST00000262901.4_Missense_Mutation_p.P561H			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	561	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AATTTTGCTGGGTTCATGTGG	0.468000													6	60					3.59834e-05	4.44363e-05	0.001168	1	0
IL16	3603	broad.mit.edu	37	15	81582867	81582867	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:81582867A>T	ENST00000394660.2	+	11	1766	c.1406A>T	c.(1405-1407)cAg>cTg	p.Q469L	IL16_ENST00000302987.4_Missense_Mutation_p.Q469L	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	469					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GAGAGGCATCAGTGGAGTCTG	0.408000													18	12					0	0	0.010504	0	0
PKNOX2	63876	broad.mit.edu	37	11	125299986	125299986	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:125299986G>T	ENST00000298282.9	+	12	1412	c.1141G>T	c.(1141-1143)Gct>Tct	p.A381S	PKNOX2_ENST00000530517.1_3'UTR|PKNOX2_ENST00000542175.1_Missense_Mutation_p.A317S	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	381						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CAACTCCATCGCTGCGGGGGT	0.627000													7	64					8.12818e-05	9.70302e-05	0.001984	1	0
DNAJC6	9829	broad.mit.edu	37	1	65858405	65858405	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:65858405G>T	ENST00000395325.3	+	12	1746	c.1589G>T	c.(1588-1590)gGt>gTt	p.G530V	DNAJC6_ENST00000371069.4_Missense_Mutation_p.G587V|DNAJC6_ENST00000263441.7_Missense_Mutation_p.G517V	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	530	Poly-Gly.|Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						CTGTTTGGGGGTGGAGGTGCA	0.577000													7	21					3.09899e-07	4.27198e-07	0.004482	1	0
TF	7018	broad.mit.edu	37	3	133467322	133467322	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:133467322A>T	ENST00000402696.3	+	2	595	c.110A>T	c.(109-111)aAg>aTg	p.K37M	TF_ENST00000475382.1_3'UTR|TFP1_ENST00000460564.1_RNA|TF_ENST00000264998.3_Intron	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	37	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GAGGCCACTAAGTGCCAGAGT	0.557000													17	29					0	0	0.004990	0	0
IFT140	9742	broad.mit.edu	37	16	1574791	1574791	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:1574791G>A	ENST00000426508.2	-	23	3354	c.2991C>T	c.(2989-2991)gtC>gtT	p.V997V	IFT140_ENST00000361339.5_Silent_p.V191V	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	997										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				TTACCTTCTGGACATTGCCCT	0.637000													15	44					0	0	0.002450	0	0
ZNF679	168417	broad.mit.edu	37	7	63727040	63727040	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:63727040G>T	ENST00000421025.1	+	5	1298	c.1029G>T	c.(1027-1029)aaG>aaT	p.K343N	ZNF679_ENST00000255746.4_Missense_Mutation_p.K343N	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						AGAAACATAAGATAATTCATA	0.403000													8	19					0.000157383	0.000184418	0.003080	1	0
TTN	7273	broad.mit.edu	37	2	179592456	179592456	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179592456C>A	ENST00000589042.1	-	68	20073	c.19849G>T	c.(19849-19851)Ggt>Tgt	p.G6617C	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G6300C|TTN_ENST00000342992.6_Missense_Mutation_p.G5373C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6300	Ig-like 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTAGGACCTGAGACAAGT	0.393000													43	171					7.05121e-23	1.36806e-22	0.010771	1	0
ALDH3B1	221	broad.mit.edu	37	11	67790069	67790069	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:67790069C>A	ENST00000539229.1	+	10	1066	c.950C>A	c.(949-951)aCg>aAg	p.T317K	ALDH3B1_ENST00000007633.8_Missense_Mutation_p.T317K|ALDH3B1_ENST00000342456.6_Missense_Mutation_p.T281K|ALDH3B1_ENST00000316367.6_Intron|ALDH3B1_ENST00000434449.1_3'UTR	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	319					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	GCAGCCCCCACGGTGCTGGTG	0.667000													19	27					5.35267e-07	7.29678e-07	0.007413	1	0
ARMC2	84071	broad.mit.edu	37	6	109274530	109274530	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:109274530G>T	ENST00000392644.4	+	13	2059	c.1891G>T	c.(1891-1893)Gtg>Ttg	p.V631L	ARMC2_ENST00000368972.3_Missense_Mutation_p.V466L	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	631							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CCCGGGGATAGTGGGCCTGCT	0.642000													6	19					5.18039e-06	6.69053e-06	0.003080	1	0
ST8SIA3	51046	broad.mit.edu	37	18	55024505	55024505	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:55024505C>A	ENST00000324000.3	+	3	2698	c.664C>A	c.(664-666)Ctc>Atc	p.L222I		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	222					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TTACAACAATCTCTTGACTAT	0.423000													8	29					0.000157383	0.000184418	0.003080	1	0
MACF1	23499	broad.mit.edu	37	1	39920741	39920741	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:39920741G>A	ENST00000564288.1	+	89	21824	c.21047G>A	c.(21046-21048)cGa>cAa	p.R7016Q	MACF1_ENST00000289893.4_Missense_Mutation_p.R5459Q|MACF1_ENST00000361689.2_Missense_Mutation_p.R4957Q|MACF1_ENST00000539005.1_Missense_Mutation_p.R4827Q|MACF1_ENST00000317713.7_Missense_Mutation_p.R4957Q|MACF1_ENST00000567887.1_Missense_Mutation_p.R7053Q|MACF1_ENST00000545844.1_Missense_Mutation_p.R4957Q|MACF1_ENST00000372915.3_Missense_Mutation_p.R6915Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6915					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.R4957Q(1)|p.R5459Q(1)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AACATTGACCGAGTTAAAGCC	0.527000													10	46					0	0	0.001368	0	0
C1QB	713	broad.mit.edu	37	1	22987440	22987440	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:22987440G>T	ENST00000509305.1	+	3	663	c.317G>T	c.(316-318)gGc>gTc	p.G106V	C1QB_ENST00000314933.6_Missense_Mutation_p.G108V			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	108	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGAGCCCCAGGCCCCAAAGGT	0.637000													17	47					9.16793e-09	1.35625e-08	0.004990	1	0
PTCHD4	442213	broad.mit.edu	37	6	47847003	47847003	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:47847003G>A	ENST00000339488.4	-	3	1610	c.1577C>T	c.(1576-1578)cCc>cTc	p.P526L		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	526						integral to membrane	hedgehog receptor activity										GTACTCTAGGGGCTCATAGAC	0.473000													7	9					0	0	0.001984	0	0
TNS3	64759	broad.mit.edu	37	7	47467916	47467916	+	Nonsense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:47467916G>C	ENST00000398879.1	-	9	749	c.383C>G	c.(382-384)tCa>tGa	p.S128*	TNS3_ENST00000311160.9_Nonsense_Mutation_p.S128*|TNS3_ENST00000458317.2_Nonsense_Mutation_p.S128*|TNS3_ENST00000355730.3_Nonsense_Mutation_p.S128*|TNS3_ENST00000442536.2_Nonsense_Mutation_p.S128*			Q68CZ2	TENS3_HUMAN	tensin 3	128	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CTACCTGGCTGAGACGTTGGT	0.527000													9	28					0	0	0.004482	0	0
MELK	9833	broad.mit.edu	37	9	36633107	36633107	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:36633107A>T	ENST00000543751.1	+	9	793	c.648A>T	c.(646-648)ccA>ccT	p.P216P	MELK_ENST00000536860.1_Silent_p.P200P|MELK_ENST00000298048.2_Silent_p.P248P|MELK_ENST00000536987.1_Silent_p.P117P|MELK_ENST00000536329.1_Silent_p.P177P|MELK_ENST00000538311.1_Silent_p.P54P|MELK_ENST00000545008.1_Silent_p.P177P|MELK_ENST00000541717.1_Silent_p.P248P	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	248	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			AGGTGGACCCAAAGAAACGGA	0.363000													19	42					0	0	0.006122	0	0
MTMR12	54545	broad.mit.edu	37	5	32263282	32263282	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:32263282C>A	ENST00000382142.3	-	7	820	c.650G>T	c.(649-651)cGg>cTg	p.R217L	MTMR12_ENST00000280285.5_Missense_Mutation_p.R217L|MTMR12_ENST00000264934.5_Missense_Mutation_p.R217L	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	217	Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GCCTTTGGTCCGTTCCAGTTC	0.418000													25	157					2.79863e-10	4.38147e-10	0.004656	1	0
SLC8A3	6547	broad.mit.edu	37	14	70633658	70633658	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:70633658T>A	ENST00000381269.2	-	2	2235	c.1482A>T	c.(1480-1482)ccA>ccT	p.P494P	SLC8A3_ENST00000528359.1_Silent_p.P494P|SLC8A3_ENST00000356921.2_Silent_p.P494P|SLC8A3_ENST00000357887.3_Silent_p.P494P|SLC8A3_ENST00000534137.1_Silent_p.P494P	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	494					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCCCCTCCTCTGGCTGCTCCT	0.512000													26	56					0	0	0.004656	0	0
ZNF208	7757	broad.mit.edu	37	19	22156554	22156554	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:22156554C>A	ENST00000397126.4	-	4	1430	c.1282G>T	c.(1282-1284)Gaa>Taa	p.E428*	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCACATTCTTCACATTTGTAG	0.393000													11	28					2.27111e-07	3.15096e-07	0.001368	1	0
CLEC3A	10143	broad.mit.edu	37	16	78064496	78064496	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:78064496G>T	ENST00000299642.4	+	3	464	c.379G>T	c.(379-381)Ggt>Tgt	p.G127C	RP11-281J9.2_ENST00000563114.1_RNA|CLEC3A_ENST00000575655.1_Missense_Mutation_p.G118C|CLEC3A_ENST00000565808.1_3'UTR	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	118	C-type lectin.				skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						CCAAGACTATGGTAAAAGGAG	0.483000													6	33					0.00116845	0.00130426	0.001168	1	0
SNRPN	6638	broad.mit.edu	37	15	25222171	25222171	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:25222171C>A	ENST00000444203.2	+	5	1466	c.427C>A	c.(427-429)Cag>Aag	p.Q143K	SNRPN_ENST00000400097.1_Missense_Mutation_p.Q139K|SNRPN_ENST00000390687.4_Missense_Mutation_p.Q139K|SNRPN_ENST00000400098.1_Missense_Mutation_p.Q139K|SNRPN_ENST00000400100.1_Missense_Mutation_p.Q139K|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000346403.6_Missense_Mutation_p.Q139K|SNRPN_ENST00000577565.1_Missense_Mutation_p.Q139K|SNRPN_ENST00000554227.2_Missense_Mutation_p.Q143K			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	139					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GGGACCATCCCAGCAGGTGAG	0.532000									Prader-Willi syndrome				9	13					0.00448238	0.00490153	0.004482	1	0
OR56A4	120793	broad.mit.edu	37	11	6023867	6023867	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6023867A>G	ENST00000330728.4	-	1	557	c.512T>C	c.(511-513)aTg>aCg	p.M171T		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATGACCATGAACGTGCA	0.498000													14	19					0	0	0.003163	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87453466	87453466	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:87453466G>A	ENST00000268616.4	-	6	774	c.557C>T	c.(556-558)cCt>cTt	p.P186L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	186					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CACGTGAGAAGGTAATGAGGC	0.393000													6	46					0	0	0.001168	0	0
CACNA2D1	781	broad.mit.edu	37	7	81596490	81596490	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:81596490T>A	ENST00000356860.3	-	31	2835	c.2497A>T	c.(2497-2499)Agt>Tgt	p.S833C	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.S845C|CACNA2D1_ENST00000535308.1_Missense_Mutation_p.S45C	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	845						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTTACGTCACTGTTTCTTTTG	0.303000													3	22					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179464352	179464352	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179464352G>C	ENST00000589042.1	-	289	56500	c.56276C>G	c.(56275-56277)aCt>aGt	p.T18759S	TTN_ENST00000342175.6_Missense_Mutation_p.T9886S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T9694S|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T9819S|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.T17118S|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T16191S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17118	Fibronectin type-III 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATAAGCCAGTGTCACTCCT	0.418000													23	355					0	0	0.002780	0	0
RCAN1	1827	broad.mit.edu	37	21	35890403	35890403	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:35890403G>A	ENST00000481448.1	-	5	1194	c.708C>T	c.(706-708)taC>taT	p.Y236Y	RCAN1_ENST00000443408.2_Silent_p.Y111Y|RCAN1_ENST00000381132.2_Silent_p.Y191Y|RCAN1_ENST00000381135.3_Silent_p.Y236Y|RCAN1_ENST00000482533.1_Silent_p.Y111Y|RCAN1_ENST00000313806.4_Silent_p.Y246Y|RCAN1_ENST00000487990.1_Silent_p.Y111Y|RCAN1_ENST00000399272.1_Silent_p.Y165Y|RCAN1_ENST00000489903.1_5'UTR			P53805	RCAN1_HUMAN	regulator of calcineurin 1	246					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)	5						GGATCGGCGTGTACTCCGGCC	0.502000													27	95					0	0	0.008361	0	0
SRC	6714	broad.mit.edu	37	20	36026134	36026134	+	Missense_Mutation	SNP	A	A	T	rs138818786		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:36026134A>T	ENST00000373578.2	+	9	1085	c.736A>T	c.(736-738)Acc>Tcc	p.T246S	SRC_ENST00000373567.2_Missense_Mutation_p.T246S|SRC_ENST00000445403.1_Missense_Mutation_p.T246S|SRC_ENST00000373558.2_Missense_Mutation_p.T252S|SRC_ENST00000358208.4_Missense_Mutation_p.T246S|SRC_ENST00000477066.1_3'UTR|SRC_ENST00000360723.4_Missense_Mutation_p.T252S	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	246	SH2.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CCGCCTCACCACCGTGTGCCC	0.687000													9	17					0	0	0.008291	0	0
TNN	63923	broad.mit.edu	37	1	175067674	175067674	+	Missense_Mutation	SNP	G	G	T	rs149504279		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:175067674G>T	ENST00000239462.4	+	9	2175	c.2062G>T	c.(2062-2064)Gtg>Ttg	p.V688L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	688	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix		p.V688M(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CATGGTGCACGTGTGGGCCCA	0.612000													21	78					2.44723e-14	4.32797e-14	0.004656	1	0
RPL26L1	51121	broad.mit.edu	37	5	172395553	172395553	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:172395553G>T	ENST00000521476.1	+	3	384	c.260G>T	c.(259-261)cGt>cTt	p.R87L	RPL26L1_ENST00000265100.2_Missense_Mutation_p.R87L|RPL26L1_ENST00000519974.1_Missense_Mutation_p.R87L|RPL26L1_ENST00000519239.1_Missense_Mutation_p.R87L			Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	87					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	7	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CGGGTGCAGCGTGAGAAGGCC	0.502000													20	90					8.34094e-07	1.12455e-06	0.008871	1	0
MMRN1	22915	broad.mit.edu	37	4	90874223	90874223	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:90874223C>A	ENST00000394980.1	+	9	3660	c.3341C>A	c.(3340-3342)cCt>cAt	p.P1114H	MMRN1_ENST00000394981.1_Missense_Mutation_p.P417H|MMRN1_ENST00000508372.1_Missense_Mutation_p.P856H|MMRN1_ENST00000264790.2_Missense_Mutation_p.P1114H			Q13201	MMRN1_HUMAN	multimerin 1	1114	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATGACTATACCTGGTCCTATC	0.368000													12	45					2.27111e-07	3.15096e-07	0.001368	1	0
OR5AK2	390181	broad.mit.edu	37	11	56756798	56756798	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56756798C>T	ENST00000326855.2	+	1	452	c.410C>T	c.(409-411)tCc>tTc	p.S137F		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						GTAATCATGTCCCGAACAGTC	0.443000													12	67					0	0	0.010729	0	0
USH2A	7399	broad.mit.edu	37	1	216495284	216495284	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:216495284T>C	ENST00000366943.2	-	9	1971	c.1585A>G	c.(1585-1587)Aca>Gca	p.T529A	USH2A_ENST00000307340.3_Missense_Mutation_p.T529A|USH2A_ENST00000366942.3_Missense_Mutation_p.T529A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	529	Laminin EGF-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGCTTGTTGTGTCGCAGTTA	0.423000										HNSCC(13;0.011)			8	76					0	0	0.008291	0	0
OR6K2	81448	broad.mit.edu	37	1	158670034	158670034	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:158670034G>T	ENST00000359610.2	-	1	452	c.409C>A	c.(409-411)Ccc>Acc	p.P137T		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					CATAGCTTGGGGGTCATGATA	0.488000													12	51					1.08611e-07	1.52534e-07	0.010729	1	0
UNC5A	90249	broad.mit.edu	37	5	176289768	176289768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:176289768C>T	ENST00000329542.4	+	2	488	c.214C>T	c.(214-216)Cag>Tag	p.Q72*		NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	72	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCCGCCACGCAGATCTTCTT	0.637000													40	89					0	0	0.011902	0	0
TRBV6-4	28603	broad.mit.edu	37	7	142250940	142250940	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:142250940C>A	ENST00000390360.3	-	0	127																											TGTCATGCTCCGTCCTGCTGC	0.498000													29	81					9.78485e-24	1.91574e-23	0.002836	1	0
SLC4A2	6522	broad.mit.edu	37	7	150764060	150764060	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150764060G>T	ENST00000485713.1	+	7	1986	c.946G>T	c.(946-948)Gcc>Tcc	p.A316S	SLC4A2_ENST00000310317.5_Missense_Mutation_p.A234S|SLC4A2_ENST00000392826.2_Missense_Mutation_p.A307S|SLC4A2_ENST00000461735.1_Missense_Mutation_p.A302S|SLC4A2_ENST00000413384.2_Missense_Mutation_p.A316S	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	316	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGACCCCGGGCCCCCCACAA	0.632000													13	87					3.27435e-08	4.74188e-08	0.002450	1	0
LRP1B	53353	broad.mit.edu	37	2	141707882	141707882	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:141707882G>A	ENST00000389484.3	-	20	4029	c.3058C>T	c.(3058-3060)Cca>Tca	p.P1020S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1020	LDL-receptor class A 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTGGCCTGGGATGCATCTG	0.453000										TSP Lung(27;0.18)			6	14					0	0	0.001168	0	0
NELFA	7469	broad.mit.edu	37	4	1985073	1985073	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:1985073C>A	ENST00000382882.3	-	11	2710	c.1593G>T	c.(1591-1593)aaG>aaT	p.K531N	NELFA_ENST00000411638.1_Missense_Mutation_p.K520N|NELFA_ENST00000542778.1_Missense_Mutation_p.K385N	NM_005663.4	NP_005654.3			negative elongation factor complex member A																		TGGGCTTGTACTTCTTGAAGC	0.577000													6	56					2.0095e-06	2.66743e-06	0.001984	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90500556	90500556	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:90500556G>A	ENST00000325643.5	+	4	1220	c.1154G>A	c.(1153-1155)cGg>cAg	p.R385Q		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAAAGAAAACGGGCCGACCAC	0.572000													10	44					0	0	0.008291	0	0
PLA2G7	7941	broad.mit.edu	37	6	46672422	46672422	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:46672422C>G	ENST00000274793.7	-	12	1397	c.1201G>C	c.(1201-1203)Gat>Cat	p.D401H	PLA2G7_ENST00000537365.1_Missense_Mutation_p.D401H	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	401					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TGATCAAAATCTTTATGAAGT	0.343000													4	25					0	0	0.001168	0	0
KRT71	112802	broad.mit.edu	37	12	52946599	52946599	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:52946599G>A	ENST00000267119.5	-	1	332	c.263C>T	c.(262-264)gCc>gTc	p.A88V		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	88	Gly-rich.|Head.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		AGGCCCCAGGGCCACACTGCC	0.642000													11	58					0	0	0.010729	0	0
PCDH10	57575	broad.mit.edu	37	4	134073551	134073551	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:134073551G>A	ENST00000264360.4	+	1	3082	c.2256G>A	c.(2254-2256)ctG>ctA	p.L752L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	752	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATACTTGTCTGGCCAGCGATT	0.592000													11	34					0	0	0.010729	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15881915	15881915	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:15881915G>T	ENST00000587443.2	-	0	982					NR_033864.1																						CGGCATCTGTGAAGTCGTGCA	0.522000													16	29					4.14922e-12	6.87802e-12	0.004007	1	0
PRSS21	10942	broad.mit.edu	37	16	2868930	2868930	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2868930C>T	ENST00000455114.1	+	4	610	c.504C>T	c.(502-504)gaC>gaT	p.D168D	PRSS21_ENST00000005995.3_Silent_p.D170D|PRSS21_ENST00000450020.3_Silent_p.D170D|PRSS21_ENST00000575739.1_3'UTR	NM_001270452.1|NM_006799.3|NM_144956.2	NP_001257381.1|NP_006790.1|NP_659205.1	Q9Y6M0	TEST_HUMAN	protease, serine, 21 (testisin)	170	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	15						ACCGGACAGACTGCTGGGTGA	0.552000													4	39					0	0	0.009096	0	0
KCNK10	54207	broad.mit.edu	37	14	88729848	88729848	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:88729848T>A	ENST00000340700.5	-	2	536	c.85A>T	c.(85-87)Aac>Tac	p.N29Y	KCNK10_ENST00000312350.5_Missense_Mutation_p.N34Y|KCNK10_ENST00000319231.5_Missense_Mutation_p.N34Y	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	29					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						GGTTGCCCGTTAGTGGCGCTC	0.607000													4	57					0	0	0.000602	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794563	140794563	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:140794563G>T	ENST00000398610.2	+	1	1821	c.1821G>T	c.(1819-1821)tgG>tgT	p.W607C	PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGCCTGGCTGTCCTACC	0.706000													25	31					5.35356e-11	8.56071e-11	0.002780	1	0
AGPAT4	56895	broad.mit.edu	37	6	161560499	161560499	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:161560499C>T	ENST00000320285.4	-	8	1209	c.997G>A	c.(997-999)Ggg>Agg	p.G333R	AGPAT4_ENST00000366911.5_3'UTR|AGPAT4_ENST00000457520.2_Missense_Mutation_p.G171R	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	333					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		AGGGAAGACCCGCTCCTGATC	0.637000													25	95					0	0	0.003330	0	0
AE000661.37	0	broad.mit.edu	37	14	22919114	22919114	+	RNA	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22919114G>A	ENST00000514473.2	-	0	225				TRDJ1_ENST00000390473.1_RNA																							AAAGGAACCCGTGTGACTGTG	0.438000													12	34					0	0	0.010729	0	0
ASIC3	9311	broad.mit.edu	37	7	150746083	150746083	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150746083C>A	ENST00000357922.4	+	1	705	c.111C>A	c.(109-111)agC>agA	p.S37R	ASIC3_ENST00000349064.5_Missense_Mutation_p.S37R|ASIC3_ENST00000297512.8_Missense_Mutation_p.S37R	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	37					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										GGCCAGGCAGCCTGAGCCTGC	0.697000													10	53					3.86212e-05	4.72862e-05	0.008291	1	0
ZNF75A	7627	broad.mit.edu	37	16	3367345	3367345	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:3367345G>T	ENST00000574298.1	+	6	840	c.367G>T	c.(367-369)Gga>Tga	p.G123*	ZNF75A_ENST00000498240.2_3'UTR	NM_153028.2	NP_694573.1	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(7)|prostate(1)	12						GCACAGAGTGGGAAAATGGCA	0.393000													6	18					3.59834e-05	4.44363e-05	0.001168	1	0
NPAP1	23742	broad.mit.edu	37	15	24921403	24921403	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:24921403C>T	ENST00000329468.2	+	1	863	c.389C>T	c.(388-390)cCa>cTa	p.P130L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTGCCTTCACCACGTGAGCCG	0.627000													11	16					0	0	0.008291	0	0
IGKV1D-12	28903	broad.mit.edu	37	2	90199071	90199071	+	RNA	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:90199071A>T	ENST00000390276.2	+	0	413																											CAGTTTGCAAAGTGGGGTCCC	0.507000													6	103					0	0	0.004482	0	0
SDPR	8436	broad.mit.edu	37	2	192701246	192701246	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:192701246C>A	ENST00000304141.4	-	2	1010	c.681G>T	c.(679-681)agG>agT	p.R227S		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	227						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TTTTCTCTGCCCTACTTTCTT	0.488000													35	73					3.67414e-24	7.20987e-24	0.012213	1	0
FAT4	79633	broad.mit.edu	37	4	126411837	126411837	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:126411837T>C	ENST00000394329.3	+	17	13873	c.13860T>C	c.(13858-13860)taT>taC	p.Y4620Y	FAT4_ENST00000335110.5_Silent_p.Y2861Y	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4620					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAGAGCACTATGACATTGACA	0.488000													12	49					0	0	0.001368	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497162	1497162	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:1497162G>T	ENST00000421627.2	+	2	437	c.303G>T	c.(301-303)gcG>gcT	p.A101A		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	180					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGGCCCACGCGGGCGCCAAGA	0.672000													5	11					1.23904e-05	1.56037e-05	0.000602	1	0
TNIK	23043	broad.mit.edu	37	3	170912349	170912349	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:170912349C>G	ENST00000436636.2	-	5	726	c.382G>C	c.(382-384)Gag>Cag	p.E128Q	TNIK_ENST00000475336.1_Missense_Mutation_p.E128Q|TNIK_ENST00000470834.1_Missense_Mutation_p.E128Q|TNIK_ENST00000369326.5_Missense_Mutation_p.E128Q|TNIK_ENST00000538048.1_Missense_Mutation_p.E128Q|TNIK_ENST00000460047.1_Missense_Mutation_p.E128Q|TNIK_ENST00000488470.1_Missense_Mutation_p.E128Q|TNIK_ENST00000357327.5_Missense_Mutation_p.E128Q|TNIK_ENST00000341852.6_Missense_Mutation_p.E128Q|TNIK_ENST00000284483.8_Missense_Mutation_p.E128Q	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	128	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GCAATCCACTCCTCTTTCAAC	0.478000													17	236					0	0	0.004990	0	0
FANCL	55120	broad.mit.edu	37	2	58431271	58431271	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:58431271C>T	ENST00000402135.3	-	6	501	c.465G>A	c.(463-465)aaG>aaA	p.K155K	FANCL_ENST00000403676.1_Silent_p.K38K|FANCL_ENST00000540646.1_Intron|FANCL_ENST00000233741.4_Silent_p.K155K|FANCL_ENST00000403295.3_Silent_p.K155K	NM_001114636.1	NP_001108108.1	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L	155					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)	8						ATACCTTTGCCTTCAACTTGA	0.393000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				15	75					0	0	0.004007	0	0
FGF13	2258	broad.mit.edu	37	X	137717645	137717645	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:137717645C>A	ENST00000315930.6	-	4	1235	c.574G>T	c.(574-576)Gct>Tct	p.A192S	FGF13_ENST00000441825.2_Missense_Mutation_p.A173S|FGF13_ENST00000541469.1_Missense_Mutation_p.A146S|FGF13_ENST00000370603.3_Missense_Mutation_p.A202S|FGF13_ENST00000305414.4_Missense_Mutation_p.A139S	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	192					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					AGAAAATGAGCTGCAGGCTTG	0.388000													18	28					1.55795e-14	2.75809e-14	0.012319	1	0
ASXL3	80816	broad.mit.edu	37	18	31326041	31326041	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:31326041A>T	ENST00000269197.5	+	12	6229	c.6229A>T	c.(6229-6231)Agc>Tgc	p.S2077C		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2077					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GGGCATATGTAGCAATATAAA	0.428000													10	63					0	0	0.008291	0	0
KRAS	3845	broad.mit.edu	37	12	25398220	25398220	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:25398220A>T	ENST00000311936.3	-	2	290	c.99T>A	c.(97-99)gaT>gaA	p.D33E	KRAS_ENST00000557334.1_Missense_Mutation_p.D33E|KRAS_ENST00000256078.4_Missense_Mutation_p.D33E|KRAS_ENST00000556131.1_Missense_Mutation_p.D33E	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	33					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding		UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CTATTGTTGGATCATATTCGT	0.373000		119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	11					0	0	0.001168	0	0
NCAPD3	23310	broad.mit.edu	37	11	134062584	134062584	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:134062584C>A	ENST00000534548.2	-	16	2109	c.2045_splice	c.e16+1	p.S682_splice		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	682					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GTTAACCTACCTCAGTTCCTG	0.483000													10	35					0.00621372	0.0067052	0.006214	1	0
XYLB	9942	broad.mit.edu	37	3	38404451	38404451	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:38404451G>C	ENST00000207870.3	+	4	324	c.234G>C	c.(232-234)aaG>aaC	p.K78N	XYLB_ENST00000542835.1_Intron	NM_005108.3	NP_005099.2	O75191	XYLB_HUMAN	xylulokinase homolog (H. influenzae)	78					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			endometrium(3)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|prostate(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TCTTGGAGAAGATGAAGGCTT	0.512000													22	51					0	0	0.002299	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872537	57872537	+	Missense_Mutation	SNP	G	G	T	rs142371581	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:57872537G>T	ENST00000393797.2	-	6	725	c.533C>A	c.(532-534)cCg>cAg	p.P178Q	ARHGAP9_ENST00000393791.3_Missense_Mutation_p.P107Q|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.P107Q|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.P107Q|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.P186Q			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	107					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			AAACAACTTCGGCCCTGGAAA	0.567000													8	21					0.000157383	0.000184418	0.003080	1	0
PXMP4	11264	broad.mit.edu	37	20	32302524	32302524	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:32302524C>A	ENST00000409299.3	-	2	224	c.132G>T	c.(130-132)cgG>cgT	p.R44R	PXMP4_ENST00000344022.3_Silent_p.R44R|PXMP4_ENST00000217398.3_Silent_p.R44R	NM_007238.4	NP_009169.3	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4, 24kDa	44						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity	p.R44L(1)		NS(1)|endometrium(2)|large_intestine(2)|lung(8)	13						CGTGAGGGGCCCGGATTTTGG	0.502000													19	115					1.10513e-12	1.86981e-12	0.002299	1	0
SI	6476	broad.mit.edu	37	3	164764657	164764657	+	Missense_Mutation	SNP	A	A	T	rs121912613		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:164764657A>T	ENST00000264382.3	-	16	1921	c.1859T>A	c.(1858-1860)cTg>cAg	p.L620Q		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	620	Isomaltase.		L -> P (in CSID; SI accumulates predominantly in the ER).		carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTGAACTCCAGCATTCCAGT	0.363000										HNSCC(35;0.089)			11	43					0	0	0.003163	0	0
ZBTB11	27107	broad.mit.edu	37	3	101384009	101384009	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:101384009C>A	ENST00000312938.4	-	4	2002	c.1422G>T	c.(1420-1422)agG>agT	p.R474S		NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CAACTTTCTGCCTATGTTTTG	0.393000													26	76					7.33532e-06	9.382e-06	0.003954	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873836	91873836	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:91873836G>T	ENST00000373094.1	+	7	4786	c.3941G>T	c.(3940-3942)aGt>aTt	p.S1314I	PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000361655.2_Missense_Mutation_p.S1296I|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S1306I|PCDH11X_ENST00000373088.1_Missense_Mutation_p.S1277I|PCDH11X_ENST00000298274.8_Missense_Mutation_p.S1277I|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S1304I	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1314					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTTCATCCCAGTGATGATTCA	0.483000													15	101					2.98522e-18	5.56571e-18	0.003163	1	0
DNAH9	1770	broad.mit.edu	37	17	11687858	11687858	+	Splice_Site	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:11687858T>C	ENST00000262442.3	+	41	8129		c.e41+2		DNAH9_ENST00000454412.2_Splice_Site	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ATTTTCCAGGTGAGTTCATCG	0.473000													20	66					0	0	0.002780	0	0
NPHP4	261734	broad.mit.edu	37	1	5927116	5927116	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:5927116T>A	ENST00000378156.4	-	25	3797	c.3532A>T	c.(3532-3534)Aac>Tac	p.N1178Y	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	1178					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CAGATGACGTTCGGGTCGCTG	0.602000													5	5					0	0	0.001168	0	0
ASCC3	10973	broad.mit.edu	37	6	101307034	101307034	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:101307034C>A	ENST00000369143.2	-	4	577	c.286G>T	c.(286-288)Gag>Tag	p.E96*	ASCC3_ENST00000369162.2_Intron|ASCC3_ENST00000522650.1_Intron	NM_022091.3	NP_071374.1	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		ttctcatcctcctcttttcca	0.388000													14	27					2.23348e-06	2.95335e-06	0.004007	1	0
BASP1	10409	broad.mit.edu	37	5	17275863	17275863	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:17275863G>T	ENST00000322611.3	+	2	798	c.538G>T	c.(538-540)Gcc>Tcc	p.A180S		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	180					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						CTCGGAGGCTGCCCCCTCTTC	0.667000													6	53					5.9392e-07	8.07712e-07	0.001168	1	0
CPE	1363	broad.mit.edu	37	4	166405746	166405746	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:166405746C>A	ENST00000402744.4	+	5	1243	c.963C>A	c.(961-963)agC>agA	p.S321R		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	321					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTGGTACAGCGTACCTGGAG	0.453000													47	159					5.34276e-22	1.02617e-21	0.003610	1	0
FLG	2312	broad.mit.edu	37	1	152281738	152281738	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152281738C>A	ENST00000368799.1	-	3	5659	c.5624G>T	c.(5623-5625)gGa>gTa	p.G1875V	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1875	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGCCGTCTCCTGATTGTTT	0.582000									Ichthyosis				77	350					1.15413e-51	2.32584e-51	0.003610	1	0
SLC39A12	221074	broad.mit.edu	37	10	18280167	18280167	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:18280167G>T	ENST00000377369.2	+	8	1630	c.1357G>T	c.(1357-1359)Gga>Tga	p.G453*	SLC39A12_ENST00000377374.4_Nonsense_Mutation_p.G453*|SLC39A12_ENST00000377371.3_Nonsense_Mutation_p.G453*|SLC39A12_ENST00000539911.1_Nonsense_Mutation_p.G319*	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	453					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						GGGATTAATTGGAGGCATCCA	0.343000													14	45					0.00185496	0.00206253	0.001855	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107423348	107423348	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:107423348G>T	ENST00000409382.3	-	6	1986	c.1376C>A	c.(1375-1377)tCc>tAc	p.S459Y	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.S459Y	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	459					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CTGCCGCACGGATGGGATATA	0.507000													14	17					9.31168e-06	1.18569e-05	0.001855	1	0
PCP4	5121	broad.mit.edu	37	21	41300977	41300977	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:41300977G>A	ENST00000328619.5	+	3	315	c.130G>A	c.(130-132)Gtg>Atg	p.V44M	PCP4_ENST00000468717.1_3'UTR	NM_006198.2	NP_006189.2	P48539	PCP4_HUMAN	Purkinje cell protein 4	44	IQ.				central nervous system development	cytosol|nucleus				large_intestine(2)|lung(1)|skin(1)	4		Prostate(19;2.65e-06)|all_epithelial(19;0.138)				ACGTGCAGCGGTGGCCATTCA	0.463000													5	47					0	0	0.000602	0	0
CHRNA4	1137	broad.mit.edu	37	20	61991028	61991028	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:61991028C>A	ENST00000370263.4	-	2	321	c.100G>T	c.(100-102)Gcc>Tcc	p.A34S	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	34					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCGGCGTGGGCCCGGGTCTCC	0.672000													4	39					0.000602214	0.000681505	0.000602	1	0
HTR2C	3358	broad.mit.edu	37	X	113965977	113965977	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:113965977C>A	ENST00000276198.1	+	4	1038	c.310C>A	c.(310-312)Cta>Ata	p.L104I	HTR2C_ENST00000371950.3_Missense_Mutation_p.L104I|HTR2C_ENST00000371951.1_Missense_Mutation_p.L104I	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	104					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GCTAGTGGGACTACTTGTCAT	0.388000													16	16					1.33834e-09	2.03954e-09	0.007413	1	0
ANKRD11	29123	broad.mit.edu	37	16	89347829	89347829	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:89347829C>A	ENST00000301030.4	-	9	5581	c.5121G>T	c.(5119-5121)acG>acT	p.T1707T	ANKRD11_ENST00000378330.2_Silent_p.T1707T	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1707						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ATAGCACCGACGTAGGGGTGG	0.672000													25	80					5.35356e-11	8.56071e-11	0.002780	1	0
MB21D1	115004	broad.mit.edu	37	6	74150094	74150094	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:74150094C>A	ENST00000370315.3	-	3	1046	c.952G>T	c.(952-954)Gtg>Ttg	p.V318L	MB21D1_ENST00000370318.1_Missense_Mutation_p.V318L	NM_138441.2	NP_612450.2	Q8N884	M21D1_HUMAN	Mab-21 domain containing 1	318										central_nervous_system(1)|large_intestine(4)|lung(1)	6						GTTATATCCACAGATATTTTT	0.413000													20	19					5.03518e-11	8.08168e-11	0.007413	1	0
SLC8A3	6547	broad.mit.edu	37	14	70530647	70530647	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:70530647C>A	ENST00000357887.3	-	3	2538		c.e3-1		SLC8A3_ENST00000381269.2_Intron|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000528359.1_Splice_Site|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000534137.1_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3						cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AATTGTTTTGCTGTGGATGGA	0.393000													7	30					8.12818e-05	9.70302e-05	0.001984	1	0
PDILT	204474	broad.mit.edu	37	16	20380973	20380973	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:20380973A>T	ENST00000302451.4	-	8	1205	c.957T>A	c.(955-957)aaT>aaA	p.N319K		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	319					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						AGACACGTCCATTTCTGGGTT	0.473000													20	68					0	0	0.010504	0	0
PSG4	5672	broad.mit.edu	37	19	43698662	43698662	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:43698662G>A	ENST00000405312.3	-	5	1310	c.1073C>T	c.(1072-1074)tCt>tTt	p.S358F	PSG4_ENST00000244295.9_Missense_Mutation_p.S265F|PSG4_ENST00000433626.2_Missense_Mutation_p.S265F	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	358	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CCGTGGGTTAGACTCGGCGAA	0.468000													87	66					0	0	0.003610	0	0
CHRM4	1132	broad.mit.edu	37	11	46407467	46407467	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:46407467A>T	ENST00000433765.2	-	1	640	c.641T>A	c.(640-642)cTg>cAg	p.L214Q		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	214					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GTGGATGTACAGCACCGTCAT	0.597000													5	15					0	0	0.000602	0	0
CALD1	800	broad.mit.edu	37	7	134617956	134617956	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:134617956A>G	ENST00000361388.2	+	5	902	c.436A>G	c.(436-438)Act>Gct	p.T146A	CALD1_ENST00000393118.2_Missense_Mutation_p.T140A|CALD1_ENST00000361901.2_Missense_Mutation_p.T146A|CALD1_ENST00000543443.1_Missense_Mutation_p.T151A|CALD1_ENST00000417172.1_Missense_Mutation_p.T146A|CALD1_ENST00000422748.1_Missense_Mutation_p.T146A|CALD1_ENST00000361675.2_Missense_Mutation_p.T146A|CALD1_ENST00000424922.1_Missense_Mutation_p.T140A|CALD1_ENST00000495522.1_Missense_Mutation_p.T140A	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	359	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						AGAAAATGAAACTACCGAGAA	0.458000													8	19					0	0	0.006214	0	0
XIRP2	129446	broad.mit.edu	37	2	168107039	168107039	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168107039C>A	ENST00000409195.1	+	9	9226	c.9137C>A	c.(9136-9138)cCc>cAc	p.P3046H	XIRP2_ENST00000409273.1_Missense_Mutation_p.P2824H|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.P3046H|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2871					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGAAATAAACCCACTAGTCTT	0.333000													15	82					1.45105e-14	2.57682e-14	0.006122	1	0
FBXL2	25827	broad.mit.edu	37	3	33419616	33419616	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:33419616A>C	ENST00000484457.1	+	12	962	c.871A>C	c.(871-873)Atg>Ctg	p.M291L	FBXL2_ENST00000446237.3_Start_Codon_SNP_p.M1L|FBXL2_ENST00000283627.6_3'UTR|FBXL2_ENST00000542085.1_Start_Codon_SNP_p.M1L|FBXL2_ENST00000538892.1_Missense_Mutation_p.M223L|FBXL2_ENST00000538181.1_Missense_Mutation_p.M207L|FBXL2_ENST00000507198.1_Missense_Mutation_p.M223L	NM_012157.3	NP_036289.3	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	291					interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						ATTGGAGAAGATGGATCTTGA	0.542000													16	22					0	0	0.003163	0	0
CPED1	79974	broad.mit.edu	37	7	120911434	120911434	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:120911434G>T	ENST00000310396.5	+	22	3285	c.2818G>T	c.(2818-2820)Ggg>Tgg	p.G940W		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TATAACAATGGGGCGTTACAA	0.348000													42	43					4.67007e-22	8.97969e-22	0.008740	1	0
NFX1	4799	broad.mit.edu	37	9	33364755	33364755	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:33364755G>A	ENST00000379540.3	+	21	3084	c.3022G>A	c.(3022-3024)Gtg>Atg	p.V1008M	NFX1_ENST00000379521.4_Missense_Mutation_p.V1008M	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	1008	R3H.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		GGAAACCCTCGTGGAGGCCGT	0.423000													4	29					0	0	0.001168	0	0
PAIP1	10605	broad.mit.edu	37	5	43548014	43548014	+	Splice_Site	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:43548014T>G	ENST00000306846.3	-	3	669	c.435_splice	c.e3-1	p.E146_splice	PAIP1_ENST00000436644.2_Splice_Site_p.E67_splice|PAIP1_ENST00000338972.4_Splice_Site_p.E34_splice|PAIP1_ENST00000514514.1_Splice_Site_p.E67_splice	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	146					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					CTCATAGGATTCCTACGGATC	0.363000													6	33					0	0	0.001168	0	0
HYAL4	23553	broad.mit.edu	37	7	123514871	123514871	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:123514871T>A	ENST00000223026.4	+	4	1649	c.1011T>A	c.(1009-1011)gtT>gtA	p.V337V	HYAL4_ENST00000476325.1_Silent_p.V337V	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	337					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						CAGGCATTGTTATTTGGGGAG	0.358000													4	49					0	0	0.001168	0	0
FBXO30	84085	broad.mit.edu	37	6	146126176	146126176	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:146126176C>A	ENST00000237281.4	-	2	1532	c.1366G>T	c.(1366-1368)Gtt>Ttt	p.V456F		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	456							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		TGAGTCCCAACGTCAATGTGA	0.433000													11	76					3.07112e-06	4.01769e-06	0.010729	1	0
NANP	140838	broad.mit.edu	37	20	25596977	25596977	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:25596977C>A	ENST00000304788.3	-	2	557	c.331G>T	c.(331-333)Gca>Tca	p.A111S		NM_152667.2	NP_689880.1	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	111					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity			endometrium(2)|lung(2)|prostate(1)	5						ACGTCTTCTGCTAGTGTCATA	0.443000													9	57					7.48243e-07	1.01278e-06	0.006214	1	0
PDE3A	5139	broad.mit.edu	37	12	20790087	20790087	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:20790087T>G	ENST00000359062.3	+	9	2095	c.2055T>G	c.(2053-2055)atT>atG	p.I685M	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	685					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGGACTCAATTATGGAGCAGC	0.343000													5	19					0	0	0.001168	0	0
MGAM	8972	broad.mit.edu	37	7	141795484	141795484	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:141795484C>A	ENST00000475668.2	+	64	7632	c.7578C>A	c.(7576-7578)ggC>ggA	p.G2526G	MGAM_ENST00000549489.2_Silent_p.G1630G			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1630					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.G1630G(1)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACACGGAGGGCGTCACTGTTG	0.483000													56	194					3.7469e-33	7.48944e-33	0.003610	1	0
WWP2	11060	broad.mit.edu	37	16	69965789	69965789	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:69965789G>T	ENST00000359154.2	+	16	1779	c.1678G>T	c.(1678-1680)Gcc>Tcc	p.A560S	WWP2_ENST00000542271.1_Missense_Mutation_p.A444S|WWP2_ENST00000568684.1_Missense_Mutation_p.A121S|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Missense_Mutation_p.A560S|WWP2_ENST00000356003.2_Missense_Mutation_p.A560S	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	560	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGGGGGCATCGCCAGGTGAGC	0.612000													19	70					5.03518e-11	8.08168e-11	0.007413	1	0
KCNH8	131096	broad.mit.edu	37	3	19559492	19559492	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:19559492C>G	ENST00000328405.2	+	15	2811	c.2545C>G	c.(2545-2547)Cca>Gca	p.P849A		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	849						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CTTTTCAGATCCAGAGATTGG	0.413000													12	29					0	0	0.001855	0	0
SVEP1	79987	broad.mit.edu	37	9	113169173	113169173	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:113169173C>A	ENST00000401783.2	-	38	9043	c.8707G>T	c.(8707-8709)Gaa>Taa	p.E2903*	SVEP1_ENST00000297826.5_Nonsense_Mutation_p.E829*|SVEP1_ENST00000374469.1_Nonsense_Mutation_p.E2880*	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2903	Sushi 25.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCCAGGCCTTCCGTCACCCCA	0.552000													12	43					1.08611e-07	1.52534e-07	0.010729	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803074	185803074	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:185803074T>C	ENST00000302277.6	+	4	3545	c.2951T>C	c.(2950-2952)aTg>aCg	p.M984T		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	984						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CAAGGAAAGATGAATGAGACA	0.418000													15	33					0	0	0.003163	0	0
NALCN	259232	broad.mit.edu	37	13	101714375	101714375	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:101714375A>C	ENST00000251127.6	-	41	4781	c.4700T>G	c.(4699-4701)gTg>gGg	p.V1567G		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1567						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGCTTGGCCACCTCCTCCTC	0.607000													4	30					0	0	0.001168	0	0
SOST	50964	broad.mit.edu	37	17	41835995	41835995	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:41835995C>T	ENST00000301691.2	-	1	161	c.115G>A	c.(115-117)Gag>Aag	p.E39K		NM_025237.2	NP_079513.1	Q9BQB4	SOST_HUMAN	sclerostin	39					negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding			large_intestine(2)|lung(3)|prostate(1)	6		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		TCTCCGAGCTCGGGGATGATT	0.632000													6	77					0	0	0.003080	0	0
TMTC1	83857	broad.mit.edu	37	12	29904703	29904703	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:29904703C>A	ENST00000256062.5	-	5	983	c.510G>T	c.(508-510)cgG>cgT	p.R170R	TMTC1_ENST00000551659.1_Silent_p.R278R|TMTC1_ENST00000552618.1_Silent_p.R278R|TMTC1_ENST00000381224.2_Silent_p.R170R|TMTC1_ENST00000539277.1_Silent_p.R278R	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	278						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGTGAGGGAACCGCTGCTGCT	0.647000													6	23					2.0095e-06	2.66743e-06	0.001984	1	0
SPTA1	6708	broad.mit.edu	37	1	158590119	158590119	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:158590119C>T	ENST00000368148.3	-	44	6438	c.6258G>A	c.(6256-6258)gaG>gaA	p.E2086E	SPTA1_ENST00000368147.3_Silent_p.E2083E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2086					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCAAGAAGTCCTCATGGTCTT	0.488000													11	35					0	0	0.010729	0	0
MUC17	140453	broad.mit.edu	37	7	100663478	100663478	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:100663478C>A	ENST00000306151.4	+	1	126	c.62C>A	c.(61-63)cCa>cAa	p.P21Q		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	21						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCTTGCCCCCACAAGCTGCT	0.667000													10	23					0.00185496	0.00206253	0.001855	1	0
HGFAC	3083	broad.mit.edu	37	4	3443844	3443844	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:3443844G>T	ENST00000382774.3	+	1	231	c.117_splice	c.e1+1	p.G39_splice	HGFAC_ENST00000511533.1_Splice_Site_p.G39_splice	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	39					proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CAGCCTGGCGGGGTGAGCACT	0.706000													16	26					8.60227e-14	1.49216e-13	0.004007	1	0
SLITRK6	84189	broad.mit.edu	37	13	86368804	86368804	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:86368804G>C	ENST00000400286.2	-	2	2438	c.1840C>G	c.(1840-1842)Ctt>Gtt	p.L614V		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	614						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATAATCAGAAGTCCCAATATT	0.413000													15	48					0	0	0.002450	0	0
RIMS2	9699	broad.mit.edu	37	8	104898412	104898412	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:104898412G>A	ENST00000507740.1	+	2	1245	c.1009G>A	c.(1009-1011)Gat>Aat	p.D337N	RIMS2_ENST00000436393.2_Missense_Mutation_p.D307N|RIMS2_ENST00000262231.10_Missense_Mutation_p.D337N|RIMS2_ENST00000406091.3_Missense_Mutation_p.D529N	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	560					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACAAGTTGTGATGATGTTGA	0.363000										HNSCC(12;0.0054)			5	15					0	0	0.004482	0	0
AP3B2	8120	broad.mit.edu	37	15	83349497	83349497	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:83349497A>G	ENST00000261722.3	-	8	989	c.782T>C	c.(781-783)cTa>cCa	p.L261P	RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535359.1_Missense_Mutation_p.L261P|AP3B2_ENST00000535348.1_Missense_Mutation_p.L229P	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	261					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GTTCTCCTCTAGTAGGGATTC	0.687000													5	16					0	0	0.001984	0	0
MMP2	4313	broad.mit.edu	37	16	55525805	55525805	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:55525805T>A	ENST00000219070.4	+	8	1782	c.1273T>A	c.(1273-1275)Tac>Aac	p.Y425N	MMP2_ENST00000570308.1_Missense_Mutation_p.Y349N|MMP2_ENST00000543485.1_Missense_Mutation_p.Y349N|MMP2_ENST00000437642.2_Missense_Mutation_p.Y375N	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	425	Collagenase-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GGCACCCATTTACACCTACAC	0.612000													14	54					0	0	0.003163	0	0
HGF	3082	broad.mit.edu	37	7	81350088	81350088	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:81350088C>A	ENST00000222390.5	-	10	1470	c.1244G>T	c.(1243-1245)tGg>tTg	p.W415L	HGF_ENST00000457544.2_Missense_Mutation_p.W410L	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	415	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GTTCTTGTCCCACATTGAACA	0.328000													12	19					1.61879e-10	2.55294e-10	0.001368	1	0
CWC25	54883	broad.mit.edu	37	17	36963160	36963160	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:36963160T>A	ENST00000225428.4	-	7	1057	c.760A>T	c.(760-762)Atg>Ttg	p.M254L	CWC25_ENST00000536127.1_Missense_Mutation_p.M191L	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	254										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						TGGTTCTTCATCCCATGCCCT	0.537000													26	42					0	0	0.005443	0	0
MAEL	84944	broad.mit.edu	37	1	166973514	166973514	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:166973514A>T	ENST00000367872.4	+	6	865	c.621A>T	c.(619-621)ccA>ccT	p.P207P	MAEL_ENST00000367870.2_Silent_p.P176P|MAEL_ENST00000491055.1_3'UTR	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	207					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						ATCCCAACCCAGGGAACTGGC	0.348000													5	41					0	0	0.000602	0	0
FBXL7	23194	broad.mit.edu	37	5	15928503	15928503	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:15928503G>T	ENST00000504595.1	+	3	1113	c.632G>T	c.(631-633)tGc>tTc	p.C211F	FBXL7_ENST00000329673.7_Missense_Mutation_p.C199F|FBXL7_ENST00000510662.1_Missense_Mutation_p.C164F	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	211					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCCCAGTGCTGCCCCGAACTG	0.582000													9	86					5.4927e-09	8.18194e-09	0.004482	1	0
LAMA2	3908	broad.mit.edu	37	6	129486760	129486760	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:129486760T>A	ENST00000421865.2	+	9	1295	c.1246T>A	c.(1246-1248)Tgc>Agc	p.C416S		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	416	Laminin EGF-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCCATGTCATTGCGATCCAAT	0.383000													5	22					0	0	0.001168	0	0
SMG7	9887	broad.mit.edu	37	1	183514116	183514116	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:183514116G>T	ENST00000367537.3	+	17	2183	c.1988G>T	c.(1987-1989)gGc>gTc	p.G663V	SMG7_ENST00000347615.2_Missense_Mutation_p.G680V|SMG7_ENST00000508461.1_Missense_Mutation_p.G638V|SMG7_ENST00000515829.2_Missense_Mutation_p.G634V|SMG7_ENST00000456731.2_Missense_Mutation_p.G592V|SMG7_ENST00000507469.1_Missense_Mutation_p.G634V			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	680	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TTTTCTATGGGCTCAGGTTAC	0.488000													17	151					3.41278e-10	5.3284e-10	0.004990	1	0
EVC2	132884	broad.mit.edu	37	4	5620325	5620325	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:5620325C>G	ENST00000310917.2	-	15	3077	c.2346G>C	c.(2344-2346)atG>atC	p.M782I	EVC2_ENST00000344408.5_Missense_Mutation_p.M862I|EVC2_ENST00000344938.1_Missense_Mutation_p.M862I	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	862						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						AGCTCCTGTCCATCTGAGCAA	0.592000													9	9					0	0	0.004482	0	0
DENND2C	163259	broad.mit.edu	37	1	115130046	115130046	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:115130046G>A	ENST00000393274.1	-	20	3342	c.2717C>T	c.(2716-2718)tCg>tTg	p.S906L	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393277.1_Missense_Mutation_p.S794L|DENND2C_ENST00000393276.3_Missense_Mutation_p.S849L	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	906										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGGGCTCCGACTCAGGAAT	0.468000													47	78					0	0	0.003610	0	0
IAPP	3375	broad.mit.edu	37	12	21531349	21531349	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:21531349T>A	ENST00000240652.3	+	3	395	c.259T>A	c.(259-261)Ttg>Atg	p.L87M	SLCO1A2_ENST00000537524.1_Intron|IAPP_ENST00000542023.1_3'UTR|SLCO1A2_ENST00000307378.6_Intron|IAPP_ENST00000539393.1_Missense_Mutation_p.L87M|SLCO1A2_ENST00000473830.1_Intron	NM_000415.2	NP_000406.1	P10997	IAPP_HUMAN	islet amyloid polypeptide	87					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity			lung(3)	3					Perindopril(DB00790)	ACTGAATTACTTGCCCCTTTA	0.383000													8	41					0	0	0.003080	0	0
RBM12B	389677	broad.mit.edu	37	8	94746596	94746596	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:94746596C>A	ENST00000399300.2	-	3	2256	c.2043G>T	c.(2041-2043)gaG>gaT	p.E681D	RBM12B_ENST00000517700.1_Intron|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	681							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCCTAAAGTCCTCCTCTGGGG	0.617000													42	75					6.68952e-21	1.2834e-20	0.013114	1	0
PROS1	5627	broad.mit.edu	37	3	93646175	93646175	+	Translation_Start_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:93646175C>A	ENST00000407433.1	-	0	320				PROS1_ENST00000394236.3_Missense_Mutation_p.Q51H			P07225	PROS_HUMAN	protein S (alpha)						leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CAAGATTACCCTGTTTGGTTT	0.398000													16	34					6.72482e-11	1.07037e-10	0.003163	1	0
CCDC172	374355	broad.mit.edu	37	10	118101646	118101646	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:118101646T>C	ENST00000333254.3	+	5	632	c.381T>C	c.(379-381)ctT>ctC	p.L127L	CCDC172_ENST00000497093.1_3'UTR	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		AAAGAGAGCTTTTGATGAAAG	0.289000													12	30					0	0	0.010729	0	0
KCNH5	27133	broad.mit.edu	37	14	63174542	63174542	+	Missense_Mutation	SNP	G	G	T	rs144667189	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:63174542G>T	ENST00000322893.7	-	11	2919	c.2651C>A	c.(2650-2652)cCg>cAg	p.P884Q	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	884					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTGCTCTAGCGGACTTCGGGC	0.502000													10	61					1.76689e-08	2.57834e-08	0.006214	1	0
NCKIPSD	51517	broad.mit.edu	37	3	48717147	48717147	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:48717147C>A	ENST00000294129.2	-	8	1470		c.e8-1		NCKIPSD_ENST00000416649.2_Splice_Site|NCKIPSD_ENST00000341520.4_Splice_Site	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain						cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTCGGTGTTCCTGGCAGGGAA	0.582000													8	18					0.000157383	0.000184418	0.003080	1	0
SLCO2A1	6578	broad.mit.edu	37	3	133664069	133664069	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:133664069C>G	ENST00000310926.4	-	10	1604	c.1331G>C	c.(1330-1332)tGc>tCc	p.C444S	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.C368S	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	444	Kazal-like.				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GTCCCTGCGGCAGGCAGGAGA	0.532000													27	148					0	0	0.005443	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306845	2306845	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:2306845C>G	ENST00000290974.2	-	8	1561	c.1222G>C	c.(1222-1224)Ggg>Cgg	p.G408R	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.G338R|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.G378R|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	408					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						TCTGCCGTCCCCTCCACGTCA	0.701000													30	28					0	0	0.009535	0	0
FNDC1	84624	broad.mit.edu	37	6	159654268	159654268	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:159654268C>G	ENST00000297267.9	+	11	2924	c.2724C>G	c.(2722-2724)gaC>gaG	p.D908E	FNDC1_ENST00000340366.6_Missense_Mutation_p.D845E	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	908						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCTGGGAGGACTTAAGGAGAA	0.607000													16	11					0	0	0.003163	0	0
PKD1L1	168507	broad.mit.edu	37	7	47933617	47933617	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:47933617C>A	ENST00000289672.2	-	15	2361	c.2311G>T	c.(2311-2313)Gtg>Ttg	p.V771L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	771	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TCCAGGCCCACACAGTAGTTG	0.587000													29	11					1.06647e-15	1.9257e-15	0.003755	1	0
USH2A	7399	broad.mit.edu	37	1	216052381	216052381	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:216052381C>A	ENST00000366943.2	-	42	8669	c.8283G>T	c.(8281-8283)atG>atT	p.M2761I	USH2A_ENST00000307340.3_Missense_Mutation_p.M2761I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2761	Fibronectin type-III 14.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAGGGTCAGGCATGTGAATCT	0.403000										HNSCC(13;0.011)			13	90					1.3612e-06	1.8252e-06	0.003163	1	0
HTR6	3362	broad.mit.edu	37	1	19992779	19992779	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:19992779G>C	ENST00000289753.1	+	1	1000	c.533G>C	c.(532-534)gGc>gCc	p.G178A		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	178					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CCCGTCCCTGGCCAGTGCCGC	0.692000													9	37					0	0	0.006214	0	0
SERPINB3	6317	broad.mit.edu	37	18	61328425	61328425	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:61328425G>T	ENST00000283752.5	-	2	169	c.26C>A	c.(25-27)aCc>aAc	p.T9N	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.T9N	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	9					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CATGAACTTGGTGTTGGCTTC	0.418000													18	94					4.35082e-09	6.56633e-09	0.010504	1	0
ITGA2B	3674	broad.mit.edu	37	17	42457493	42457493	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:42457493C>A	ENST00000262407.5	-	17	1660	c.1629G>T	c.(1627-1629)cgG>cgT	p.R543R	ITGA2B_ENST00000353281.4_Silent_p.R543R|ITGA2B_ENST00000377068.3_3'UTR	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	543					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGGCTTCTGCCGGTCCAGCT	0.682000													14	31					4.7546e-09	7.13813e-09	0.004007	1	0
PACRGL	133015	broad.mit.edu	37	4	20728923	20728923	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:20728923A>T	ENST00000360916.5	+	8	1016	c.625A>T	c.(625-627)Atc>Ttc	p.I209F	PACRGL_ENST00000507634.1_Missense_Mutation_p.I209F|PACRGL_ENST00000538990.1_Missense_Mutation_p.I111F|PACRGL_ENST00000503585.1_Missense_Mutation_p.I236F|PACRGL_ENST00000295290.8_Missense_Mutation_p.I209F|PACRGL_ENST00000444671.2_Missense_Mutation_p.I111F|PACRGL_ENST00000502374.1_3'UTR|PACRGL_ENST00000502938.1_Missense_Mutation_p.I75F|PACRGL_ENST00000513459.1_Missense_Mutation_p.I156F	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	236							binding			endometrium(2)|lung(7)|prostate(1)	10						CCTTAGCATCATCAAATCTAA	0.378000													16	55					0	0	0.004007	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562978	145562978	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:145562978C>A	ENST00000355594.4	+	10	2753	c.2666C>A	c.(2665-2667)gCc>gAc	p.A889D		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	889										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCTCAGGCAGCCGAACAAGAG	0.647000													6	39					8.12818e-05	9.70302e-05	0.001984	1	0
FAM131B	9715	broad.mit.edu	37	7	143053924	143053924	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:143053924G>T	ENST00000409408.1	-	6	2426	c.718C>A	c.(718-720)Cca>Aca	p.P240T	FAM131B_ENST00000443739.2_Missense_Mutation_p.P268T|FAM131B_ENST00000409222.3_Missense_Mutation_p.P240T|FAM131B_ENST00000409578.1_Missense_Mutation_p.P256T|FAM131B_ENST00000409346.1_Missense_Mutation_p.P240T			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	240										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					CCTGAAGCTGGTTGGGAAGGT	0.602000													43	71					6.4771e-29	1.2857e-28	0.010771	1	0
ETS2	2114	broad.mit.edu	37	21	40194635	40194635	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:40194635A>C	ENST00000360214.3	+	11	1692	c.1232A>C	c.(1231-1233)aAg>aCg	p.K411T	ETS2_ENST00000360938.3_Missense_Mutation_p.K411T	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	411					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				AATAAGCCCAAGATGAACTAC	0.483000													10	45					0	0	0.010729	0	0
ITGA8	8516	broad.mit.edu	37	10	15647745	15647745	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:15647745C>A	ENST00000378076.3	-	19	2301	c.1948G>T	c.(1948-1950)Gac>Tac	p.D650Y		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	650					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						AGCTTCAAGTCAGGAACACAC	0.393000													8	28					5.18039e-06	6.69053e-06	0.003080	1	0
RGS4	5999	broad.mit.edu	37	1	163042650	163042650	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:163042650C>A	ENST00000421743.2	+	4	656	c.496C>A	c.(496-498)Cat>Aat	p.H166N	RGS4_ENST00000527809.1_Missense_Mutation_p.H51N|RGS4_ENST00000367909.6_Missense_Mutation_p.H69N|RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000367906.3_Missense_Mutation_p.H51N|RGS4_ENST00000531057.1_Missense_Mutation_p.H69N|RGS4_ENST00000367908.4_Missense_Mutation_p.H69N	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	69	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						CCTGATTAGTCATGAATGTAA	0.403000													6	18					5.18039e-06	6.69053e-06	0.003080	1	0
HEPHL1	341208	broad.mit.edu	37	11	93834389	93834389	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:93834389C>G	ENST00000315765.9	+	14	2471	c.2463C>G	c.(2461-2463)aaC>aaG	p.N821K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	821	Plastocyanin-like 5.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGGTGGGCAACACCGTCCTGA	0.453000													3	108					0	0	0.009096	0	0
OR9G4	283189	broad.mit.edu	37	11	56511071	56511071	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56511071G>T	ENST00000302957.3	-	1	216	c.217C>A	c.(217-219)Cct>Act	p.P73T		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AAGTACATAGGTGTATGCAAG	0.408000													10	33					0.00621372	0.0067052	0.006214	1	0
LAMC1	3915	broad.mit.edu	37	1	183106963	183106963	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:183106963G>T	ENST00000258341.4	+	26	4730		c.e26+1			NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)						axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCAGGGATGGTAAGAGGTTT	0.383000													12	11					5.50884e-06	7.0564e-06	0.001368	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140794562	140794562	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:140794562G>T	ENST00000398610.2	+	1	1820	c.1820G>T	c.(1819-1821)tGg>tTg	p.W607L	PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAACGCCTGGCTGTCCTAC	0.706000													27	32					7.92952e-12	1.30065e-11	0.003954	1	0
CDC42BPG	55561	broad.mit.edu	37	11	64596949	64596949	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:64596949C>G	ENST00000342711.5	-	30	3960	c.3961G>C	c.(3961-3963)Ggc>Cgc	p.G1321R		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1321	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						TTACCCCAGCCCATGGGCGCT	0.642000													19	27					0	0	0.012319	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076401	57076401	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:57076401C>A	ENST00000532437.1	-	5	4095	c.3784G>T	c.(3784-3786)Ggt>Tgt	p.G1262C	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.G1262C			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1262	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GCCTCCACACCTGACCAGTCA	0.582000													42	136					1.15505e-17	2.1442e-17	0.009718	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29897000	29897000	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:29897000C>A	ENST00000308713.5	-	8	1806	c.1279G>T	c.(1279-1281)Gag>Tag	p.E427*	SEZ6L2_ENST00000537485.1_Nonsense_Mutation_p.E383*|SEZ6L2_ENST00000346932.5_Nonsense_Mutation_p.E313*|SEZ6L2_ENST00000350527.3_Nonsense_Mutation_p.E357*	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	427	CUB 2.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGACCCCGCTCGGGGACATCG	0.587000													18	46					5.3912e-06	6.94714e-06	0.006122	1	0
CHD7	55636	broad.mit.edu	37	8	61766937	61766937	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:61766937G>A	ENST00000423902.2	+	32	7270	c.6791G>A	c.(6790-6792)aGa>aAa	p.R2264K	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2264					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCTGTCTCTAGAGGGAAGAAT	0.413000													3	30					0	0	0.004672	0	0
HFE2	148738	broad.mit.edu	37	1	145414786	145414786	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:145414786G>T	ENST00000336751.5	+	2	243	c.5G>T	c.(4-6)gGg>gTg	p.G2V	HFE2_ENST00000357836.5_Intron|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000475797.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	2					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATAGGTATGGGGGAGCCAGGC	0.567000													19	39					1.00905e-13	1.74327e-13	0.008871	1	0
HGF	3082	broad.mit.edu	37	7	81386583	81386583	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:81386583C>A	ENST00000222390.5	-	4	630	c.404G>T	c.(403-405)aGc>aTc	p.S135I	HGF_ENST00000444829.2_Missense_Mutation_p.S135I|HGF_ENST00000453411.1_Missense_Mutation_p.S135I|HGF_ENST00000453018.1_Missense_Mutation_p.S32I|HGF_ENST00000457544.2_Missense_Mutation_p.S135I|HGF_ENST00000354224.6_Missense_Mutation_p.S135I|HGF_ENST00000423064.2_Missense_Mutation_p.S135I	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	135	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TCCCTTGTAGCTGCGTCCTTT	0.363000													6	62					1.12685e-05	1.4264e-05	0.004482	1	0
DACH1	1602	broad.mit.edu	37	13	72049304	72049304	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:72049304G>A	ENST00000305425.4	-	10	2480	c.2058C>T	c.(2056-2058)ggC>ggT	p.G686G	DACH1_ENST00000354591.4_Silent_p.G484G|DACH1_ENST00000359684.2_Silent_p.G738G|DACH1_ENST00000313174.7_Silent_p.G538G	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	736	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CTGTTCTGCCGCCACTGCGGT	0.408000													16	24					0	0	0.004990	0	0
INSL4	3641	broad.mit.edu	37	9	5233662	5233662	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:5233662T>C	ENST00000239316.4	+	2	310	c.205T>C	c.(205-207)Tca>Cca	p.S69P		NM_002195.1	NP_002186.1	Q14641	INSL4_HUMAN	insulin-like 4 (placenta)	69					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding			endometrium(2)|lung(2)|skin(1)|urinary_tract(1)	6	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		AGAAATGGTGTCAACCTCCAA	0.403000													14	21					0	0	0.001855	0	0
FAM129A	116496	broad.mit.edu	37	1	184764355	184764355	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:184764355G>A	ENST00000367511.3	-	14	2736	c.2543C>T	c.(2542-2544)tCt>tTt	p.S848F	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	848	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GATGGGGTCAGAACCTAAGGT	0.602000													7	58					0	0	0.001984	0	0
FAM160A2	84067	broad.mit.edu	37	11	6245023	6245023	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6245023C>A	ENST00000265978.4	-	3	952	c.594G>T	c.(592-594)ctG>ctT	p.L198L	FAM160A2_ENST00000524416.1_Silent_p.L198L|FAM160A2_ENST00000449352.2_Silent_p.L198L	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	198					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GAGGTGGCTGCAGGAAGAACT	0.602000													17	50					2.23348e-06	2.95335e-06	0.004007	1	0
FLT4	2324	broad.mit.edu	37	5	180038481	180038481	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:180038481T>A	ENST00000261937.6	-	27	3616		c.e27-2		FLT4_ENST00000393347.3_Splice_Site|FLT4_ENST00000502649.1_Splice_Site	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTCTTCCTCCTGGCGGGAACA	0.682000													8	29					0	0	0.004482	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871691	51871691	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:51871691T>C	ENST00000371497.5	+	2	2581	c.1694T>C	c.(1693-1695)cTg>cCg	p.L565P	TSHZ2_ENST00000329613.6_Missense_Mutation_p.L562P|TSHZ2_ENST00000603338.2_Missense_Mutation_p.L562P	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	565					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TCCCAGGTACTGCAGATCCGG	0.587000													14	73					0	0	0.004007	0	0
MMS22L	253714	broad.mit.edu	37	6	97677230	97677230	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:97677230C>A	ENST00000275053.4	-	14	1844	c.1579G>T	c.(1579-1581)Ggt>Tgt	p.G527C	MMS22L_ENST00000369251.2_Missense_Mutation_p.G487C	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	527					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						TTCTGTAGACCAACTTCAGTT	0.318000													6	11					0.00116845	0.00130426	0.001168	1	0
MAP2K6	5608	broad.mit.edu	37	17	67501928	67501928	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:67501928G>T	ENST00000590474.1	+	2	311	c.24G>T	c.(22-24)aaG>aaT	p.K8N	MAP2K6_ENST00000589647.1_5'UTR	NM_002758.3	NP_002749.2	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	8					activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	20	Breast(10;6.05e-10)					TAGGCAAGAAGCGAAACCCTG	0.433000													34	64					5.43694e-19	1.02367e-18	0.005524	1	0
CDA	978	broad.mit.edu	37	1	20915674	20915674	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:20915674C>T	ENST00000375071.3	+	1	234	c.52C>T	c.(52-54)Ctg>Ttg	p.L18L	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	18					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	TGTCCAGCAGCTGCTGGTTTG	0.627000													8	42					0	0	0.006214	0	0
CSPG4	1464	broad.mit.edu	37	15	75982619	75982619	+	Missense_Mutation	SNP	C	C	T	rs141025839		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:75982619C>T	ENST00000308508.5	-	3	879	c.787G>A	c.(787-789)Gtg>Atg	p.V263M		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	263	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						TTCTCCACCACGGCCCGCAGG	0.627000													23	16					0	0	0.003954	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317158	154317158	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:154317158G>T	ENST00000368489.3	+	21	2282	c.2282G>T	c.(2281-2283)gGc>gTc	p.G761V		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	747					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CGCTCCGTAGGCAACGGCTTC	0.552000											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	66					3.99206e-14	7.00239e-14	0.007413	1	0
CIDEC	63924	broad.mit.edu	37	3	9911574	9911574	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:9911574G>A	ENST00000336832.2	-	5	685	c.546C>T	c.(544-546)cgC>cgT	p.R182R	CIDEC_ENST00000383817.1_Intron|CIDEC_ENST00000455015.1_Silent_p.R108R|CIDEC_ENST00000430427.1_Silent_p.R192R|CIDEC_ENST00000443115.1_Intron|CIDEC_ENST00000423850.1_Silent_p.R108R	NM_001199552.1|NM_001199623.1|NM_022094.3	NP_001186481.1|NP_001186552.1|NP_071377.2	Q96AQ7	CIDEC_HUMAN	cell death-inducing DFFA-like effector c	182					apoptosis|induction of apoptosis	cytosol|focal adhesion|nucleus				breast(2)|central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	8	Medulloblastoma(99;0.227)					ACTTCATGATGCGCTTGGCCC	0.532000													8	31					0	0	0.003080	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471813	47471813	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:47471813C>A	ENST00000266581.4	-	2	1439	c.973G>T	c.(973-975)Ggt>Tgt	p.G325C	AMIGO2_ENST00000321382.3_Missense_Mutation_p.G325C|AMIGO2_ENST00000550413.1_Missense_Mutation_p.G325C|AMIGO2_ENST00000429635.1_Missense_Mutation_p.G325C	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	325	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					TTATCTGGACCCACCCAGATG	0.468000													20	91					1.50039e-11	2.44009e-11	0.012319	1	0
FAT3	120114	broad.mit.edu	37	11	92258098	92258098	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:92258098C>A	ENST00000298047.6	+	2	3608	c.3591C>A	c.(3589-3591)gcC>gcA	p.A1197A	FAT3_ENST00000409404.2_Silent_p.A1197A|FAT3_ENST00000525166.1_Silent_p.A1047A|FAT3_ENST00000541502.1_Silent_p.A1197A			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1197	Cadherin 11.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTTTTTTGCCATCAATATCA	0.373000										TCGA Ovarian(4;0.039)			8	36					0.000157383	0.000184418	0.003080	1	0
VAV3	10451	broad.mit.edu	37	1	108145771	108145771	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:108145771A>G	ENST00000370056.4	-	23	2304	c.2030T>C	c.(2029-2031)aTg>aCg	p.M677T	VAV3_ENST00000415432.2_Missense_Mutation_p.M117T|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000544443.1_Missense_Mutation_p.M81T|VAV3_ENST00000527011.1_Missense_Mutation_p.M677T	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	677	SH2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CAATCTTTCCATTGCTCCAGC	0.358000													8	40					0	0	0.004482	0	0
MUC17	140453	broad.mit.edu	37	7	100684764	100684764	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:100684764A>G	ENST00000306151.4	+	3	10131	c.10067A>G	c.(10066-10068)gAg>gGg	p.E3356G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3356	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGTTCTGAGGCTAGCACC	0.483000													87	520					0	0	0.003610	0	0
KEL	3792	broad.mit.edu	37	7	142651292	142651292	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:142651292C>G	ENST00000355265.2	-	8	1377	c.903G>C	c.(901-903)atG>atC	p.M301I	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	301					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					CGATAGTGACCATCTGGAAGA	0.552000													12	26					0	0	0.010729	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644684	20644684	+	RNA	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:20644684G>C	ENST00000428453.1	-	0	3187																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ACAGGGAAGGGAGACGGCCAC	0.632000													4	9					0	0	0.009096	0	0
CXorf66	347487	broad.mit.edu	37	X	139047602	139047602	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:139047602C>A	ENST00000370540.1	-	1	77	c.54G>T	c.(52-54)atG>atT	p.M18I		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	18						integral to membrane		p.M18I(1)		breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						GGTTTGTAGTCATGCAATTAT	0.318000													14	37					0.00244969	0.00270458	0.002450	1	0
ASIC2	40	broad.mit.edu	37	17	31352947	31352947	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:31352947G>A	ENST00000225823.2	-	5	2064	c.1192C>T	c.(1192-1194)Cta>Tta	p.L398L	ASIC2_ENST00000359872.6_Silent_p.L347L|ASIC2_ENST00000448983.1_5'UTR	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	347					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	TACTGACCTAGGGCAGGCTCT	0.527000													15	33					0	0	0.002450	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798067	55798067	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55798067C>A	ENST00000313555.1	+	1	173	c.173C>A	c.(172-174)cCc>cAc	p.P58H		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					CTTCAAATTCCCATGTATTAT	0.343000													9	27					5.4927e-09	8.18194e-09	0.004482	1	0
XIRP2	129446	broad.mit.edu	37	2	168100659	168100659	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168100659A>C	ENST00000409195.1	+	9	2846	c.2757A>C	c.(2755-2757)caA>caC	p.Q919H	XIRP2_ENST00000409273.1_Missense_Mutation_p.Q697H|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.Q919H|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	744					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTGAAACCCAACCTCTGGAAG	0.363000													3	34					0	0	0.004672	0	0
B3GAT2	135152	broad.mit.edu	37	6	71603926	71603926	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:71603926C>A	ENST00000230053.6	-	2	1249	c.641G>T	c.(640-642)gGg>gTg	p.G214V		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	214					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						GTAGCGCCGCCCACCAACCAG	0.547000													33	44					4.4194e-11	7.11992e-11	0.002836	1	0
GIMAP4	55303	broad.mit.edu	37	7	150267034	150267034	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150267034A>T	ENST00000255945.2	+	2	220	c.45A>T	c.(43-45)ccA>ccT	p.P15P	GIMAP4_ENST00000461940.1_Silent_p.P15P|GIMAP4_ENST00000494750.1_Intron	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	15							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGCACACCAGGGGCCAGTT	0.557000													16	51					0	0	0.007413	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744697	135744697	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:135744697G>T	ENST00000375845.3	-	7	1775	c.1745C>A	c.(1744-1746)cCc>cAc	p.P582H	MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Missense_Mutation_p.P599H|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.P469H	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CCAAGGCCTGGGGTCCACAAG	0.428000													12	57					1.08611e-07	1.52534e-07	0.010729	1	0
PI15	51050	broad.mit.edu	37	8	75737725	75737725	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:75737725G>C	ENST00000260113.2	+	2	420	c.241G>C	c.(241-243)Gtg>Ctg	p.V81L	PI15_ENST00000523773.1_Missense_Mutation_p.V81L|RP11-758M4.4_ENST00000518128.1_RNA|RP11-758M4.4_ENST00000523860.1_RNA	NM_015886.3	NP_056970.1	O43692	PI15_HUMAN	peptidase inhibitor 15	81						extracellular region	peptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|skin(1)	30	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TCGGGGCAAAGTGTTCCCACC	0.388000													6	27					0	0	0.001168	0	0
ROBO1	6091	broad.mit.edu	37	3	79638972	79638972	+	Splice_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:79638972A>T	ENST00000464233.1	-	2	202		c.e2+1			NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CACAGCACTTACCTGGAATAA	0.368000													21	42					0	0	0.002299	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84517949	84517949	+	RNA	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:84517949G>A	ENST00000331369.5	+	0	143																											CGAAATGGCCGCGTCCAGTCA	0.587000													4	11					0	0	0.009096	0	0
GRIP1	23426	broad.mit.edu	37	12	66773138	66773138	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:66773138G>T	ENST00000359742.4	-	20	2783	c.2543C>A	c.(2542-2544)cCa>cAa	p.P848Q	GRIP1_ENST00000286445.7_Missense_Mutation_p.P848Q|GRIP1_ENST00000398016.3_Missense_Mutation_p.P796Q			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	848					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTTAGTGACTGGGGACAAGCT	0.483000													13	124					6.31663e-08	9.04103e-08	0.003163	1	0
LILRP2	79166	broad.mit.edu	37	19	55222078	55222078	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:55222078C>A	ENST00000413439.1	+	0	1605																											GCTGAATTCCCCATGAGTCCT	0.602000													34	41					9.93527e-08	1.41497e-07	0.002836	1	0
HSD3B2	3284	broad.mit.edu	37	1	119964541	119964541	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:119964541C>A	ENST00000543831.1	+	4	666	c.417C>A	c.(415-417)aaC>aaA	p.N139K	HSD3B2_ENST00000369416.3_Missense_Mutation_p.N139K	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	139					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TCATCCAGAACGGCCACGAAG	0.537000													30	54					3.73148e-12	6.1975e-12	0.007291	1	0
RBBP5	5929	broad.mit.edu	37	1	205064008	205064008	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:205064008G>A	ENST00000264515.6	-	13	1722	c.1581C>T	c.(1579-1581)ccC>ccT	p.P527P	RBBP5_ENST00000367164.1_Intron	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	527					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			TACCTGTCAAGGGCTGGCTGA	0.483000													23	103					0	0	0.003954	0	0
AAMP	14	broad.mit.edu	37	2	219130619	219130619	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:219130619C>T	ENST00000248450.4	-	7	984	c.814G>A	c.(814-816)Ggc>Agc	p.G272S	AAMP_ENST00000420660.1_Missense_Mutation_p.G253S|AAMP_ENST00000444053.1_Missense_Mutation_p.G273S			Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	272					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(4)|ovary(2)|skin(1)	11		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATCAAGCTGCCATCCTGGTTG	0.637000													4	17					0	0	0.009096	0	0
PIGG	54872	broad.mit.edu	37	4	494291	494291	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:494291G>A	ENST00000453061.2	+	2	367	c.261G>A	c.(259-261)gtG>gtA	p.V87V	PIGG_ENST00000502311.1_3'UTR|PIGG_ENST00000509768.1_5'UTR|PIGG_ENST00000503111.1_5'UTR|PIGG_ENST00000296306.7_5'UTR|PIGG_ENST00000504346.1_5'UTR|PIGG_ENST00000383028.4_Silent_p.V87V|PIGG_ENST00000310340.5_Silent_p.V87V|PIGG_ENST00000536264.1_5'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	87					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CAAAGGGTGTGAAATTTATGC	0.438000													14	33					0	0	0.003163	0	0
ABCA12	26154	broad.mit.edu	37	2	215838689	215838689	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:215838689C>T	ENST00000272895.7	-	36	5765	c.5546G>A	c.(5545-5547)tGc>tAc	p.C1849Y	ABCA12_ENST00000389661.4_Missense_Mutation_p.C1531Y	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1849					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATTTTCTGAGCAGGAGCAAAC	0.378000													15	29					0	0	0.003163	0	0
OR11G2	390439	broad.mit.edu	37	14	20666300	20666300	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20666300C>A	ENST00000357366.3	+	1	806	c.806C>A	c.(805-807)gCa>gAa	p.A269E		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTCCCTTCAGCAGCTGGGAGA	0.517000													18	145					9.16793e-09	1.35625e-08	0.004990	1	0
DOCK3	1795	broad.mit.edu	37	3	51399971	51399971	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:51399971A>T	ENST00000266037.9	+	49	5182	c.5159A>T	c.(5158-5160)aAc>aTc	p.N1720I		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1720						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCGTATCCCAACCCCAGGTAC	0.547000													12	26					0	0	0.001855	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432292	107432292	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:107432292G>T	ENST00000340010.5	-	4	549	c.365C>A	c.(364-366)tCc>tAc	p.S122Y	SLC26A3_ENST00000422236.2_Missense_Mutation_p.S87Y	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	122					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity	p.S122F(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TATGTGTCTGGAAGTGCCGAA	0.403000													25	61					8.24728e-16	1.49232e-15	0.004656	1	0
MAEA	10296	broad.mit.edu	37	4	1309328	1309328	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:1309328C>T	ENST00000303400.4	+	3	459	c.396C>T	c.(394-396)caC>caT	p.H132H	MAEA_ENST00000264750.6_Silent_p.H132H|MAEA_ENST00000505839.1_Silent_p.H84H|MAEA_ENST00000452175.2_Intron|MAEA_ENST00000505177.2_Silent_p.H132H|MAEA_ENST00000510794.1_Silent_p.H131H|MAEA_ENST00000514708.1_Silent_p.H132H	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	132	LisH.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			TGGTGGAGCACCTGCTGCGTT	0.672000													25	46					0	0	0.004656	0	0
AHCTF1	25909	broad.mit.edu	37	1	247024416	247024416	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247024416C>A	ENST00000366508.1	-	29	4158	c.4022G>T	c.(4021-4023)gGa>gTa	p.G1341V	AHCTF1_ENST00000326225.3_Missense_Mutation_p.G1315V|AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Missense_Mutation_p.G1306V			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1306	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ACTGCTGTTTCCTTTGCTCAC	0.448000													8	27					0.000157383	0.000184418	0.003080	1	0
ZNF711	7552	broad.mit.edu	37	X	84520185	84520185	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:84520185T>A	ENST00000360700.4	+	6	1726	c.840T>A	c.(838-840)ctT>ctA	p.L280L	ZNF711_ENST00000395402.1_Silent_p.L258L|ZNF711_ENST00000542798.1_Silent_p.L76L|ZNF711_ENST00000373165.3_Silent_p.L280L|ZNF711_ENST00000276123.3_Silent_p.L280L			Q9Y462	ZN711_HUMAN	zinc finger protein 711	280					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						CTGGAGTGCTTGACCAGAGCC	0.398000													4	20					0	0	0.000602	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338566	28338566	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:28338566C>T	ENST00000284987.5	-	1	266	c.145G>A	c.(145-147)Gag>Aag	p.E49K		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	49					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGCACCTCCTCCCCCTGCCGC	0.751000													3	13					0	0	0.004672	0	0
MIR523	574471	broad.mit.edu	37	19	54201656	54201656	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:54201656C>A	ENST00000385281.1	+	0	18					NR_030193.1																						CTGTGACCCTCTAGAGGGAAG	0.423000													26	26					2.61193e-14	4.60976e-14	0.009535	1	0
CDC42BPG	55561	broad.mit.edu	37	11	64596950	64596950	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:64596950C>A	ENST00000342711.5	-	30	3959	c.3960G>T	c.(3958-3960)atG>atT	p.M1320I		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1320	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						TACCCCAGCCCATGGGCGCTG	0.642000													20	27					1.87028e-06	2.49033e-06	0.012319	1	0
OR9G1	390174	broad.mit.edu	37	11	56468178	56468178	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56468178G>T	ENST00000312153.1	+	1	315	c.315G>T	c.(313-315)ggG>ggT	p.G105G		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TCTCTGCAGGGCTGGCCTATA	0.532000													12	96					9.31168e-06	1.18569e-05	0.001855	1	0
SCML4	256380	broad.mit.edu	37	6	108070974	108070974	+	Missense_Mutation	SNP	G	G	T	rs112676572		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:108070974G>T	ENST00000369022.2	-	2	235	c.26C>A	c.(25-27)cCg>cAg	p.P9Q	SCML4_ENST00000369021.3_Missense_Mutation_p.P38Q|SCML4_ENST00000369020.3_Missense_Mutation_p.P67Q			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		GGTACTCCGCGGAGGTGAGAG	0.582000													9	30					1.76689e-08	2.57834e-08	0.006214	1	0
PEX2	5828	broad.mit.edu	37	8	77895554	77895554	+	Silent	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:77895554T>G	ENST00000419564.2	-	4	1325	c.861A>C	c.(859-861)gtA>gtC	p.V287V	PEX2_ENST00000522527.1_Silent_p.V287V|PEX2_ENST00000357039.4_Silent_p.V287V|PEX2_ENST00000520103.1_Silent_p.V287V	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	287					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						GCAGACTGTGTACTTCTGTGC	0.383000													21	96					0	0	0.002780	0	0
WNK1	65125	broad.mit.edu	37	12	977171	977171	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:977171G>T	ENST00000537687.1	+	9	2922	c.2279G>T	c.(2278-2280)cGt>cTt	p.R760L	WNK1_ENST00000315939.6_Intron|WNK1_ENST00000574564.1_Missense_Mutation_p.R59L|WNK1_ENST00000530271.2_Missense_Mutation_p.R845L|WNK1_ENST00000340908.4_Intron|WNK1_ENST00000535572.1_Intron	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	763					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCCCAGCGGCGTAAGAGCACC	0.517000													17	73					2.48551e-13	4.25133e-13	0.004990	1	0
PPP1R21	129285	broad.mit.edu	37	2	48687233	48687233	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:48687233G>T	ENST00000294952.8	+	6	697		c.e6-1		PPP1R21_ENST00000281394.4_Splice_Site|PPP1R21_ENST00000449090.2_Splice_Site	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21											endometrium(2)|kidney(4)|lung(9)	15						CTGAAATTCAGGTGAAATCTC	0.433000													6	6					0.00116845	0.00130426	0.001168	1	0
OR4N4	283694	broad.mit.edu	37	15	22383165	22383165	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:22383165A>T	ENST00000328795.4	+	1	784	c.693A>T	c.(691-693)gaA>gaT	p.E231D	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CAGCTTCTGAAGGGAAGAACA	0.493000													11	111					0	0	0.010729	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135239893	135239893	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:135239893G>A	ENST00000265605.2	-	7	1192	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	ALDH8A1_ENST00000367847.2_Missense_Mutation_p.P325L|ALDH8A1_ENST00000367845.2_Missense_Mutation_p.P321L	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	375					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		TATCACCGTGGGAAGCATAAA	0.512000													22	75					0	0	0.010504	0	0
LMNA	4000	broad.mit.edu	37	1	156105882	156105882	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:156105882A>G	ENST00000368300.4	+	6	1339	c.1127A>G	c.(1126-1128)tAc>tGc	p.Y376C	LMNA_ENST00000368301.2_Missense_Mutation_p.Y376C|LMNA_ENST00000473598.2_Missense_Mutation_p.Y277C|LMNA_ENST00000347559.2_Missense_Mutation_p.Y376C|LMNA_ENST00000361308.4_Missense_Mutation_p.Y376C|LMNA_ENST00000448611.2_Missense_Mutation_p.Y264C|LMNA_ENST00000392353.3_Missense_Mutation_p.Y295C|LMNA_ENST00000368299.3_Missense_Mutation_p.Y376C|LMNA_ENST00000496738.1_3'UTR|LMNA_ENST00000368297.1_Missense_Mutation_p.Y295C	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	376	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					ATCCACGCCTACCGCAAGCTC	0.647000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				7	27					0	0	0.008291	0	0
MBIP	51562	broad.mit.edu	37	14	36785946	36785946	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:36785946G>A	ENST00000416007.4	-	2	289	c.202C>T	c.(202-204)Cct>Tct	p.P68S	MBIP_ENST00000318473.7_Missense_Mutation_p.P68S|MBIP_ENST00000359527.7_Missense_Mutation_p.P68S	NM_001144891.1|NM_016586.2	NP_001138363.1|NP_057670.2	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1	68					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity			breast(2)|large_intestine(1)|lung(5)	8	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		AGCAATGCAGGCTGGAATGCC	0.388000													4	39					0	0	0.009096	0	0
OR2C3	81472	broad.mit.edu	37	1	247695553	247695553	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247695553C>T	ENST00000366487.3	-	2	622	c.261G>A	c.(259-261)tgG>tgA	p.W87*	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TCTGTGGTCCCCAGAGGTTAG	0.547000													16	53					0	0	0.003163	0	0
KDR	3791	broad.mit.edu	37	4	55987331	55987331	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:55987331G>T	ENST00000263923.4	-	2	389	c.94C>A	c.(94-96)Ccc>Acc	p.P32T		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	32					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CTGAGCCTGGGCAGATCAAGA	0.348000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			3	39					0.00909568	0.00969341	0.009096	1	0
TUBB2A	7280	broad.mit.edu	37	6	3155958	3155958	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:3155958C>A	ENST00000333628.3	-	3	240	c.178G>T	c.(178-180)Gta>Tta	p.V60L	TUBB2A_ENST00000489942.1_5'UTR	NM_001069.2	NP_001060.1	Q13885	TBB2A_HUMAN	tubulin, beta 2A class IIa	60					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCCCGAGGTACATATTTGTTA	0.527000													7	38					1.06961e-07	1.51455e-07	0.003080	1	0
KRT79	338785	broad.mit.edu	37	12	53223890	53223890	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:53223890C>T	ENST00000330553.5	-	4	806	c.772G>A	c.(772-774)Gca>Aca	p.A258T		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	258	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCATGTATGCTGCATCCACA	0.582000													11	22					0	0	0.010729	0	0
LYST	1130	broad.mit.edu	37	1	235972423	235972423	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:235972423G>A	ENST00000389794.3	-	5	1869	c.1695C>T	c.(1693-1695)tcC>tcT	p.S565S	LYST_ENST00000389793.2_Silent_p.S565S|LYST_ENST00000536965.1_Silent_p.S565S			Q99698	LYST_HUMAN	lysosomal trafficking regulator	565					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGCTGCTCAAGGAAGCCTGCT	0.458000													18	76					0	0	0.008871	0	0
EPHA4	2043	broad.mit.edu	37	2	222429103	222429103	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:222429103C>A	ENST00000281821.2	-	3	212	c.171G>T	c.(169-171)gtG>gtT	p.V57V	EPHA4_ENST00000392071.4_Silent_p.V6V|EPHA4_ENST00000409938.1_Silent_p.V57V|EPHA4_ENST00000409854.1_Silent_p.V57V	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	57						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CCATGATACTCACTTCCTCCC	0.418000													4	72					1.23904e-05	1.56037e-05	0.000602	1	0
TRIM26	7726	broad.mit.edu	37	6	30166684	30166684	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:30166684C>A	ENST00000454678.2	-	4	633	c.197G>T	c.(196-198)cGa>cTa	p.R66L	TRIM26_ENST00000487829.1_5'UTR|TRIM26_ENST00000453195.1_Missense_Mutation_p.R66L|TRIM26_ENST00000437089.1_Missense_Mutation_p.R66L	NM_003449.4	NP_003440.1	Q12899	TRI26_HUMAN	tripartite motif containing 26	66							DNA binding|zinc ion binding			lung(1)|ovary(2)	3						CCACACGGGTCGGATGTTCTC	0.632000													19	29					5.03518e-11	8.08168e-11	0.007413	1	0
PPP2R2B	5521	broad.mit.edu	37	5	146030164	146030164	+	Missense_Mutation	SNP	C	C	A	rs143485788	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:146030164C>A	ENST00000394413.3	-	5	1141	c.571G>T	c.(571-573)Gct>Tct	p.A191S	PPP2R2B_ENST00000453001.1_Missense_Mutation_p.A191S|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.A191S|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.A194S|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.A257S|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.A180S|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.A249S|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.A191S|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.A197S|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.A180S			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	191					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTCATCAGCGGACATGTAG	0.423000													8	17					0.000157383	0.000184418	0.003080	1	0
GPR142	350383	broad.mit.edu	37	17	72367926	72367926	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:72367926C>A	ENST00000335666.4	+	4	624	c.576C>A	c.(574-576)tcC>tcA	p.S192S		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	192						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						GGAGGCCCTCCTACTACTACC	0.652000													10	18					3.07112e-06	4.01769e-06	0.010729	1	0
ASF1A	25842	broad.mit.edu	37	6	119222019	119222019	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:119222019C>A	ENST00000229595.5	+	2	392	c.198C>A	c.(196-198)ccC>ccA	p.P66P	MCM9_ENST00000316316.6_Intron	NM_014034.2	NP_054753.1	Q9Y294	ASF1A_HUMAN	anti-silencing function 1A histone chaperone	66	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding			endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		GTCCTGTTCCCGCAGGAAGGC	0.348000													28	108					4.74835e-14	8.31204e-14	0.010818	1	0
PSG7	5676	broad.mit.edu	37	19	43439795	43439795	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:43439795C>A	ENST00000446844.3	-	0	280				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CCAGATGTGGCCAGTAAGATT	0.453000													62	77					1.4051e-37	2.8217e-37	0.003610	1	0
ZCCHC8	55596	broad.mit.edu	37	12	122973980	122973980	+	Nonsense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:122973980T>A	ENST00000336229.4	-	5	584	c.454A>T	c.(454-456)Aaa>Taa	p.K152*	ZCCHC8_ENST00000543897.1_5'UTR|ZCCHC8_ENST00000536306.1_5'UTR	NM_017612.3	NP_060082.2	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	152						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TCTTCCACTTTGTGGTCCTCC	0.368000													6	12					0	0	0.001984	0	0
COL4A4	1286	broad.mit.edu	37	2	227886798	227886798	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:227886798C>T	ENST00000396625.3	-	44	4389	c.4182G>A	c.(4180-4182)atG>atA	p.M1394I	COL4A4_ENST00000329662.7_Missense_Mutation_p.M1391I	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1394	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CAGGGAGCCCCATGGCTCCTT	0.527000													44	158					0	0	0.010771	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29900017	29900017	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:29900017G>T	ENST00000308713.5	-	6	1410	c.883C>A	c.(883-885)Cgg>Agg	p.R295R	SEZ6L2_ENST00000537485.1_Silent_p.R251R|SEZ6L2_ENST00000346932.5_Silent_p.R181R|SEZ6L2_ENST00000562159.1_5'UTR|SEZ6L2_ENST00000350527.3_Silent_p.R225R	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	295	Sushi 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGGGCCGGCCGGGGAGGGAAG	0.642000													5	20					0.00198382	0.00219304	0.001984	1	0
MYT1L	23040	broad.mit.edu	37	2	1805558	1805558	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:1805558A>G	ENST00000399161.2	-	23	3933	c.3186T>C	c.(3184-3186)gaT>gaC	p.D1062D	MYT1L_ENST00000428368.2_Silent_p.D1060D|MYT1L_ENST00000407844.1_Silent_p.D58D	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1062					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGATTTCTTCATCATTTTCTA	0.294000													13	74					0	0	0.001855	0	0
SCAND3	114821	broad.mit.edu	37	6	28543261	28543261	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:28543261C>A	ENST00000452236.2	-	3	1838	c.1221G>T	c.(1219-1221)cgG>cgT	p.R407R		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	407	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ACTTTAATGACCGCAAAAAAG	0.383000													5	40					0.000602214	0.000681505	0.000602	1	0
POGK	57645	broad.mit.edu	37	1	166818420	166818420	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:166818420G>A	ENST00000367875.1	+	5	964	c.604G>A	c.(604-606)Gca>Aca	p.A202T	POGK_ENST00000367876.4_Missense_Mutation_p.A202T|POGK_ENST00000536514.1_Missense_Mutation_p.A117T|POGK_ENST00000537173.1_Missense_Mutation_p.A84T			Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	202					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	22						CAGTTACGACGCAGGGTTCAA	0.542000													9	35					0	0	0.006214	0	0
PER1	5187	broad.mit.edu	37	17	8049961	8049961	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:8049961C>A	ENST00000317276.4	-	15	2095	c.1858G>T	c.(1858-1860)Gcc>Tcc	p.A620S	PER1_ENST00000581082.1_Missense_Mutation_p.A600S|PER1_ENST00000354903.5_Missense_Mutation_p.A604S	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	620	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CAGCTGGAGGCTTCTTTCCTC	0.642000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					9	26					3.09899e-07	4.27198e-07	0.004482	1	0
PIK3C2G	5288	broad.mit.edu	37	12	18573954	18573954	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:18573954C>A	ENST00000433979.1	+	16	2388	c.2272C>A	c.(2272-2274)Cca>Aca	p.P758T	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P758T|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P799T	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	758					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GGAATATCTCCCACAGCTAGT	0.343000													23	38					5.49717e-05	6.72093e-05	0.003330	1	0
CASKIN1	57524	broad.mit.edu	37	16	2239298	2239298	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2239298T>C	ENST00000343516.6	-	5	519	c.427A>G	c.(427-429)Atg>Gtg	p.M143V		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	143					signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TTGTCCACCATGCACGGGTTA	0.697000													7	30					0	0	0.003080	0	0
BCR	613	broad.mit.edu	37	22	23523546	23523546	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:23523546G>T	ENST00000305877.8	+	1	1150	c.399G>T	c.(397-399)agG>agT	p.R133S	BCR_ENST00000398512.5_Missense_Mutation_p.R133S|BCR_ENST00000359540.3_Missense_Mutation_p.R133S	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	133	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						CCGCCCGCAGGCCCGGGGCAG	0.801000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								4	12					0.00909568	0.00969341	0.009096	1	0
DENND2C	163259	broad.mit.edu	37	1	115168040	115168040	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:115168040T>A	ENST00000393274.1	-	4	1191	c.566A>T	c.(565-567)aAg>aTg	p.K189M	DENND2C_ENST00000393277.1_Missense_Mutation_p.K189M|DENND2C_ENST00000393276.3_Missense_Mutation_p.K189M	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	189										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTAAGCTCTTGGTTATTCC	0.383000													4	34					0	0	0.000602	0	0
BDKRB2	624	broad.mit.edu	37	14	96707667	96707667	+	Silent	SNP	C	C	A	rs138780728		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:96707667C>A	ENST00000542454.2	+	3	4009	c.921C>A	c.(919-921)atC>atA	p.I307I	BDKRB2_ENST00000554311.1_Silent_p.I334I|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000306005.3_Silent_p.I334I|BDKRB2_ENST00000539359.1_Silent_p.I307I			P30411	BKRB2_HUMAN	bradykinin receptor B2	334					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		TGTACGTGATCGTGGGCAAGC	0.562000													8	29					0.00307968	0.00338706	0.003080	1	0
PTCHD3	374308	broad.mit.edu	37	10	27687737	27687737	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:27687737G>T	ENST00000438700.3	-	4	1907	c.1790C>A	c.(1789-1791)aCa>aAa	p.T597K		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	597					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CTCACTCCTTGTGAGAAAGGG	0.378000													8	22					1.26484e-09	1.93097e-09	0.003080	1	0
TPTE	7179	broad.mit.edu	37	21	10910354	10910354	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:10910354C>A	ENST00000298232.7	-	21	1715	c.1348G>T	c.(1348-1350)Gac>Tac	p.D450Y	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.D468Y|TPTE_ENST00000342420.5_Missense_Mutation_p.D430Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	468	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTAGACCGTCGAATACATCA	0.338000													21	92					1.22574e-08	1.81017e-08	0.002299	1	0
FANCM	57697	broad.mit.edu	37	14	45645576	45645576	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:45645576A>T	ENST00000267430.5	+	14	3704	c.3619A>T	c.(3619-3621)Aga>Tga	p.R1207*	FANCM_ENST00000542564.2_Nonsense_Mutation_p.R1181*	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1207					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TCGTGATCAGAGAGGTGTACA	0.348000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				11	38					0	0	0.008291	0	0
IFNK	56832	broad.mit.edu	37	9	27524686	27524686	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:27524686C>A	ENST00000276943.2	+	1	375	c.352C>A	c.(352-354)Ctt>Att	p.L118I	MOB3B_ENST00000262244.5_Intron	NM_020124.2	NP_064509.2	Q9P0W0	IFNK_HUMAN	interferon, kappa	118					cytokine-mediated signaling pathway|defense response|natural killer cell activation|negative regulation of cell proliferation|positive regulation of innate immune response|regulation of transcription, DNA-dependent|response to virus	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			large_intestine(1)	1		all_neural(11;7.9e-11)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.000158)		CCAAATAGGACTTGATCAGCA	0.408000													17	146					1.01871e-10	1.61547e-10	0.008871	1	0
SLC26A3	1811	broad.mit.edu	37	7	107432291	107432291	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:107432291G>T	ENST00000340010.5	-	4	550	c.366C>A	c.(364-366)tcC>tcA	p.S122S	SLC26A3_ENST00000422236.2_Silent_p.S87S	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	122					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATATGTGTCTGGAAGTGCCGA	0.403000													24	61					3.6726e-16	6.67358e-16	0.003954	1	0
CDCA3	83461	broad.mit.edu	37	12	6958844	6958844	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:6958844C>A	ENST00000422785.3	-	4	533	c.429G>T	c.(427-429)gaG>gaT	p.E143D	CDCA3_ENST00000538862.2_Missense_Mutation_p.E143D|CDCA3_ENST00000535406.1_Missense_Mutation_p.E143D|CDCA3_ENST00000540683.1_Missense_Mutation_p.E143D|CDCA3_ENST00000229265.6_Missense_Mutation_p.E118D			Q99618	CDCA3_HUMAN	cell division cycle associated 3	143					cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						TGGAGGGGAACTCAGTCTGGT	0.547000													38	43					6.05902e-23	1.18089e-22	0.003755	1	0
SCN11A	11280	broad.mit.edu	37	3	38888354	38888354	+	Missense_Mutation	SNP	C	C	A	rs143852849	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:38888354C>A	ENST00000302328.3	-	26	5405	c.5207G>T	c.(5206-5208)gGt>gTt	p.G1736V	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1698V|SCN11A_ENST00000450244.1_Missense_Mutation_p.G1736V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1736					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AATAGCAGCACCTCTTTCCTC	0.443000													18	62					3.32936e-07	4.57487e-07	0.006122	1	0
CAMK2D	817	broad.mit.edu	37	4	114424132	114424132	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:114424132T>A	ENST00000454265.2	-	15	1877	c.1017_splice	c.e15-1	p.E340_splice	CAMK2D_ENST00000394524.3_Intron|CAMK2D_ENST00000514328.1_Intron|CAMK2D_ENST00000296402.5_Intron|CAMK2D_ENST00000505990.1_Splice_Site_p.E349_splice|CAMK2D_ENST00000511664.1_Splice_Site_p.E349_splice|CAMK2D_ENST00000394522.3_Splice_Site_p.E329_splice|CAMK2D_ENST00000508738.1_Intron|CAMK2D_ENST00000342666.5_Intron|CAMK2D_ENST00000394526.2_Intron|CAMK2D_ENST00000515496.1_Intron|CAMK2D_ENST00000429180.1_Intron|CAMK2D_ENST00000418639.2_Splice_Site_p.E329_splice|CAMK2D_ENST00000379773.2_Intron			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	327					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AGTTTGGGGCTCCTGAGTGAG	0.383000													11	35					0	0	0.008291	0	0
NOS3	4846	broad.mit.edu	37	7	150698406	150698406	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150698406T>A	ENST00000297494.3	+	11	1678	c.1321T>A	c.(1321-1323)Tgc>Agc	p.C441S	NOS3_ENST00000484524.1_Missense_Mutation_p.C441S|NOS3_ENST00000467517.1_Missense_Mutation_p.C441S|NOS3_ENST00000461406.1_Missense_Mutation_p.C235S	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	441	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CAGGGGGGGCTGCCCTGCAGA	0.617000													57	67					0	0	0.003610	0	0
DMP1	1758	broad.mit.edu	37	4	88584385	88584385	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:88584385G>A	ENST00000339673.6	+	6	1554	c.1455G>A	c.(1453-1455)gaG>gaA	p.E485E	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Silent_p.E469E|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	485					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AAAACATTGAGATAGAGAGCC	0.463000													22	110					0	0	0.010504	0	0
TBC1D9	23158	broad.mit.edu	37	4	141598060	141598060	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:141598060G>T	ENST00000442267.2	-	6	1121	c.1047C>A	c.(1045-1047)atC>atA	p.I349I		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	349	GRAM 2.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CACGGAGCGGGATAATGAGGC	0.358000													10	44					0.000442599	0.00050587	0.006214	1	0
MMP16	4325	broad.mit.edu	37	8	89086929	89086929	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:89086929C>G	ENST00000286614.6	-	7	1407	c.1126G>C	c.(1126-1128)Gga>Cga	p.G376R	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	376	Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						ATTGGGTATCCATCCATCACC	0.463000													13	63					0	0	0.001368	0	0
PLA2R1	22925	broad.mit.edu	37	2	160884857	160884857	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:160884857G>T	ENST00000283243.7	-	6	1177	c.971C>A	c.(970-972)cCa>cAa	p.P324Q	PLA2R1_ENST00000392771.1_Missense_Mutation_p.P324Q	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	324	C-type lectin 1.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TTCAACAAATGGCTCAAAATT	0.353000													5	68					1.024e-07	1.45717e-07	0.000602	1	0
SESN3	143686	broad.mit.edu	37	11	94963990	94963990	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:94963990G>C	ENST00000536441.1	-	1	371	c.35C>G	c.(34-36)gCc>gGc	p.A12G	RP11-712B9.2_ENST00000536683.1_RNA|SESN3_ENST00000416495.2_Missense_Mutation_p.A12G|SESN3_ENST00000537480.1_Intron|RP11-712B9.2_ENST00000543150.1_RNA|SESN3_ENST00000278499.2_Intron|SESN3_ENST00000393234.1_Missense_Mutation_p.A12G|RP11-712B9.2_ENST00000534891.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	12					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		CAGGTAGTTGGCGGCGGCCGA	0.751000													5	15					0	0	0.000602	0	0
OR5A1	219982	broad.mit.edu	37	11	59211169	59211169	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:59211169C>A	ENST00000302030.2	+	1	553	c.528C>A	c.(526-528)atC>atA	p.I176I		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GACCCAACATCATCAACCACT	0.537000													100	161					5.25376e-55	1.06e-54	0.003610	1	0
CUX2	23316	broad.mit.edu	37	12	111729346	111729346	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:111729346C>A	ENST00000261726.6	+	5	580	c.426C>A	c.(424-426)ctC>ctA	p.L142L		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	142						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CCGAGCTCCTCAGCCCCAAAG	0.602000													8	20					0.00621372	0.0067052	0.006214	1	0
MYF6	4618	broad.mit.edu	37	12	81101569	81101569	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:81101569C>T	ENST00000228641.3	+	1	293	c.71C>T	c.(70-72)cCa>cTa	p.P24L		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	24					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						ACTCTGCAGCCATTAGAAGTG	0.527000													25	49					0	0	0.003330	0	0
PAPPA2	60676	broad.mit.edu	37	1	176809373	176809373	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:176809373G>C	ENST00000367662.3	+	22	6431	c.5267G>C	c.(5266-5268)gGa>gCa	p.G1756A		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1756					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TATGACGGGGGAGACTGCTGC	0.537000													23	95					0	0	0.003330	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504519	66504519	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:66504519A>G	ENST00000360242.5	+	2	636	c.519A>G	c.(517-519)caA>caG	p.Q173Q	CCDC102B_ENST00000319445.6_Silent_p.Q173Q|CCDC102B_ENST00000584156.1_Silent_p.Q173Q|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000358653.5_Silent_p.Q173Q	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	173										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				ATACAGACCAATTTCAATTGA	0.373000													18	79					0	0	0.004990	0	0
KCNA4	3739	broad.mit.edu	37	11	30033219	30033219	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:30033219C>A	ENST00000328224.6	-	2	2240	c.1007G>T	c.(1006-1008)aGg>aTg	p.R336M		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	336						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GACGAGATCCCTGTCGTCCCT	0.512000													10	63					0.00621372	0.0067052	0.006214	1	0
HR	55806	broad.mit.edu	37	8	21978634	21978634	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:21978634A>G	ENST00000381418.4	-	10	3791	c.2311T>C	c.(2311-2313)Ttg>Ctg	p.L771L	HR_ENST00000312841.8_Silent_p.L771L	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	771							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TCATGGCCCAAGCAGAGTTTG	0.652000													15	61					0	0	0.003163	0	0
METTL4	64863	broad.mit.edu	37	18	2555033	2555033	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:2555033C>A	ENST00000319888.6	-	4	1262	c.464G>T	c.(463-465)aGg>aTg	p.R155M	METTL4_ENST00000574538.1_Missense_Mutation_p.R155M			Q8N3J2	METL4_HUMAN	methyltransferase like 4	155					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						AATCAGCTCCCTGATCTGTAA	0.338000													26	50					7.16444e-05	8.64258e-05	0.003954	1	0
NPFFR2	10886	broad.mit.edu	37	4	72994393	72994393	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:72994393G>A	ENST00000308744.6	+	2	489	c.391G>A	c.(391-393)Gat>Aat	p.D131N	NPFFR2_ENST00000395999.1_Missense_Mutation_p.D32N|NPFFR2_ENST00000344413.5_Intron|NPFFR2_ENST00000358749.3_Missense_Mutation_p.D29N	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	131					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCTGTACTCAGATATTAATAT	0.373000													5	24					0	0	0.000602	0	0
SNRNP40	9410	broad.mit.edu	37	1	31744346	31744346	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:31744346C>A	ENST00000263694.4	-	6	673	c.654_splice	c.e6-1	p.V219_splice	SNRNP40_ENST00000489853.1_5'UTR|SNRNP40_ENST00000446633.2_Splice_Site_p.V219_splice	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	219						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						AGGTCCCAGACCTGCAAAAAC	0.443000													7	50					0.000157383	0.000184418	0.003080	1	0
PTPRT	11122	broad.mit.edu	37	20	40979359	40979359	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:40979359G>T	ENST00000373198.3	-	11	2009	c.1774C>A	c.(1774-1776)Cct>Act	p.P592T	PTPRT_ENST00000356100.2_Missense_Mutation_p.P592T|PTPRT_ENST00000373184.1_Missense_Mutation_p.P592T|PTPRT_ENST00000373193.3_Missense_Mutation_p.P592T|PTPRT_ENST00000373190.1_Missense_Mutation_p.P592T|PTPRT_ENST00000373201.1_Missense_Mutation_p.P592T|PTPRT_ENST00000373187.1_Missense_Mutation_p.P592T	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	592	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCGTACTCAGGCATGGATGGA	0.562000													27	50					7.26314e-15	1.30191e-14	0.007291	1	0
NOVA1	4857	broad.mit.edu	37	14	26918139	26918139	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:26918139C>A	ENST00000539517.2	-	5	867	c.550G>T	c.(550-552)Ggt>Tgt	p.G184C	NOVA1_ENST00000267422.7_Missense_Mutation_p.G62C|NOVA1_ENST00000465357.2_Missense_Mutation_p.G160C	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	187	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		ATTATCAGACCTGCTGTGCTG	0.398000													5	70					0.000602214	0.000681505	0.000602	1	0
OR2T10	127069	broad.mit.edu	37	1	248756959	248756959	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248756959C>A	ENST00000330500.2	-	1	141	c.111G>T	c.(109-111)atG>atT	p.M37I		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGACACAGCCATCAAAAATA	0.448000													13	41					0.00010058	0.000119569	0.001368	1	0
MGA	23269	broad.mit.edu	37	15	41989080	41989080	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:41989080G>A	ENST00000219905.7	+	3	2053	c.1872G>A	c.(1870-1872)aaG>aaA	p.K624K	MGA_ENST00000389936.4_Silent_p.K624K|MGA_ENST00000545763.1_Silent_p.K624K|MGA_ENST00000566586.1_Silent_p.K624K|MGA_ENST00000570161.1_Silent_p.K624K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	624						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AACTCTGTAAGGCAGGACGAC	0.443000													6	3					0	0	0.001168	0	0
PCDH15	65217	broad.mit.edu	37	10	55780091	55780091	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:55780091G>T	ENST00000373965.2	-	21	3027	c.2633C>A	c.(2632-2634)aCa>aAa	p.T878K	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.T871K|PCDH15_ENST00000395445.1_Missense_Mutation_p.T878K|PCDH15_ENST00000437009.1_Missense_Mutation_p.T800K|PCDH15_ENST00000409834.1_Missense_Mutation_p.T482K|PCDH15_ENST00000395438.1_Missense_Mutation_p.T871K|PCDH15_ENST00000395432.2_Missense_Mutation_p.T834K|PCDH15_ENST00000414778.1_Missense_Mutation_p.T876K|PCDH15_ENST00000320301.6_Missense_Mutation_p.T871K|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.T849K|PCDH15_ENST00000395430.1_Missense_Mutation_p.T871K|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.T871K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	871	Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TAGTTCTCCTGTAAATGGATG	0.403000										HNSCC(58;0.16)			29	81					1.08312e-15	1.95371e-15	0.009535	1	0
CRYBA1	1411	broad.mit.edu	37	17	27579114	27579114	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:27579114G>T	ENST00000225387.3	+	4	249	c.248G>T	c.(247-249)gGg>gTg	p.G83V		NM_005208.4	NP_005199.2	P05813	CRBA1_HUMAN	crystallin, beta A1	83	Beta/gamma crystallin 'Greek key' 2.				visual perception	soluble fraction	structural constituent of eye lens			breast(1)|large_intestine(2)|lung(1)|prostate(1)	5			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			AGCTTCTGTGGGCAACAGTTT	0.507000											OREG0024293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	82					6.31663e-08	9.04103e-08	0.003163	1	0
UBE2NL	389898	broad.mit.edu	37	X	142967330	142967330	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:142967330C>A	ENST00000370494.1	+	1	158	c.128C>A	c.(127-129)tCa>tAa	p.S43*		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	43							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGGGGAATCAAAGGATTCC	0.463000													31	38					8.16721e-17	1.49356e-16	0.010818	1	0
VPS35	55737	broad.mit.edu	37	16	46705670	46705670	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:46705670C>A	ENST00000299138.7	-	12	1529	c.1471G>T	c.(1471-1473)Gtg>Ttg	p.V491L		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	491					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				AAGCGGCCCACAAGGCTCTGC	0.463000													9	18					1.58986e-06	2.11859e-06	0.008291	1	0
IRS4	8471	broad.mit.edu	37	X	107976299	107976299	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:107976299G>A	ENST00000372129.2	-	1	3352	c.3276C>T	c.(3274-3276)ttC>ttT	p.F1092F		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1092						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CTGCTGCAAAGAAACTTTGAG	0.582000													5	84					0	0	0.002450	0	0
MUC16	94025	broad.mit.edu	37	19	9058542	9058542	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9058542G>A	ENST00000397910.4	-	3	29107	c.28904C>T	c.(28903-28905)aCa>aTa	p.T9635I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9637	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGTGACATTGTGGACTGAGC	0.498000													6	46					0	0	0.001984	0	0
SERINC5	256987	broad.mit.edu	37	5	79498704	79498704	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:79498704C>A	ENST00000507668.2	-	2	346		c.e2+1		SERINC5_ENST00000512972.2_Splice_Site|SERINC5_ENST00000513907.1_Splice_Site|SERINC5_ENST00000512721.1_Splice_Site|SERINC5_ENST00000509193.1_Splice_Site	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5						phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane		p.?(2)		endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GACAAACTTACGTGCTCTTTC	0.493000													4	12					0.00909568	0.00969341	0.009096	1	0
HECTD4	283450	broad.mit.edu	37	12	112622545	112622545	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:112622545C>T	ENST00000550722.1	-	61	10182	c.9787G>A	c.(9787-9789)Gac>Aac	p.D3263N	HECTD4_ENST00000377560.5_Missense_Mutation_p.D3237N|HECTD4_ENST00000430131.2_Missense_Mutation_p.D2987N	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		ACGCCCTCGTCCAGGTGGGTG	0.667000													30	90					0	0	0.012213	0	0
DCHS1	8642	broad.mit.edu	37	11	6661175	6661175	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6661175G>T	ENST00000299441.3	-	2	2081	c.1670C>A	c.(1669-1671)cCt>cAt	p.P557H		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	557	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAGGCTAGAGGGGGCAGGCC	0.562000													15	48					2.23348e-06	2.95335e-06	0.004007	1	0
MAATS1	89876	broad.mit.edu	37	3	119445164	119445164	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:119445164G>T	ENST00000273390.5	+	7	906	c.829G>T	c.(829-831)Gag>Tag	p.E277*		NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		GGAGAGGAAGGAGTGGGCCTT	0.488000													7	16					5.18039e-06	6.69053e-06	0.003080	1	0
SPRTN	83932	broad.mit.edu	37	1	231488891	231488891	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:231488891C>T	ENST00000295050.7	+	5	1590	c.1254C>T	c.(1252-1254)gaC>gaT	p.D418D		NM_001010984.2|NM_032018.5	NP_001010984.1|NP_114407.3			SprT-like N-terminal domain																		CTGTTTTTGACAATTTTTTTA	0.398000													10	26					0	0	0.008291	0	0
OPN1SW	611	broad.mit.edu	37	7	128415650	128415650	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:128415650C>G	ENST00000249389.2	-	1	194	c.195G>C	c.(193-195)ttG>ttC	p.L65F		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	65					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						GGGGCTGCCGCAACTTTTTGT	0.552000													38	86					0	0	0.005524	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963430	88963430	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:88963430C>A	ENST00000333190.4	+	4	1743	c.1134C>A	c.(1132-1134)gcC>gcA	p.A378A		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	378						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATAGTGATGCCAGGATATCTG	0.393000										HNSCC(36;0.09)			14	29					6.31663e-08	9.04103e-08	0.003163	1	0
OTOF	9381	broad.mit.edu	37	2	26691303	26691303	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:26691303C>T	ENST00000272371.2	-	33	4189	c.4063G>A	c.(4063-4065)Gag>Aag	p.E1355K	OTOF_ENST00000403946.3_Missense_Mutation_p.E1355K|OTOF_ENST00000402415.3_Missense_Mutation_p.E665K|OTOF_ENST00000339598.3_Missense_Mutation_p.E588K|OTOF_ENST00000338581.6_Missense_Mutation_p.E588K	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1355					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTCCTTCTCCTCCAAGTCA	0.567000													6	38					0	0	0.003080	0	0
EPHA10	284656	broad.mit.edu	37	1	38227570	38227570	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:38227570C>A	ENST00000373048.4	-	3	356	c.357G>T	c.(355-357)gcG>gcT	p.A119A	EPHA10_ENST00000319637.6_Silent_p.A119A|EPHA10_ENST00000427468.2_Silent_p.A119A	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	119						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGCAGGTACCCGCGGCGCCAG	0.657000													16	121					3.52763e-06	4.59742e-06	0.004990	1	0
RECK	8434	broad.mit.edu	37	9	36117143	36117143	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:36117143G>T	ENST00000377966.3	+	17	2788	c.2222G>T	c.(2221-2223)gGa>gTa	p.G741V		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	741	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TACCAAAGAGGAAAAAGCCTC	0.438000													7	28					5.18039e-06	6.69053e-06	0.003080	1	0
USH2A	7399	broad.mit.edu	37	1	216462717	216462717	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:216462717G>C	ENST00000366943.2	-	11	2262	c.1876C>G	c.(1876-1878)Cga>Gga	p.R626G	USH2A_ENST00000307340.3_Missense_Mutation_p.R626G|USH2A_ENST00000366942.3_Missense_Mutation_p.R626G			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	626	Laminin EGF-like 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCAACTTGTCGGAAAAAGTAA	0.413000										HNSCC(13;0.011)			7	43					0	0	0.006214	0	0
NBPF1	55672	broad.mit.edu	37	1	16893836	16893836	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:16893836C>T	ENST00000430580.2	-	25	3564	c.2677G>A	c.(2677-2679)Gag>Aag	p.E893K	NBPF1_ENST00000432949.1_Missense_Mutation_p.G296E|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	893	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCCAGCAGCTCCCTGCTGAGC	0.483000													35	1047					0	0	0.003271	0	0
GABRR2	2570	broad.mit.edu	37	6	89977760	89977760	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:89977760G>T	ENST00000402938.3	-	5	701	c.568C>A	c.(568-570)Cag>Aag	p.Q190K	GABRR2_ENST00000602399.1_Missense_Mutation_p.Q215K			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	215					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		GAACAGGTCTGGGAGTCCAGG	0.453000													3	8					0.004672	0.0050606	0.004672	1	0
MMP26	56547	broad.mit.edu	37	11	5010967	5010967	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:5010967G>A	ENST00000380390.1	+	3	405	c.189G>A	c.(187-189)cgG>cgA	p.R63R	MMP26_ENST00000477339.1_3'UTR|MMP26_ENST00000300762.1_Silent_p.R63R			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	63					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		AATTCCATCGGAATGGGACAG	0.522000													7	15					0	0	0.003080	0	0
KLK4	9622	broad.mit.edu	37	19	51410274	51410274	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51410274C>A	ENST00000324041.1	-	5	680	c.681G>T	c.(679-681)ccG>ccT	p.P227P	KLK4_ENST00000431178.2_3'UTR	NM_004917.3	NP_004908.3	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4	227	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(8)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CTTGGCCACACGGGGCTTTTC	0.547000													18	56					1.37522e-17	2.54468e-17	0.007413	1	0
RFWD2	64326	broad.mit.edu	37	1	175996778	175996778	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:175996778C>A	ENST00000367669.3	-	15	2173	c.1659G>T	c.(1657-1659)gaG>gaT	p.E553D	RFWD2_ENST00000308769.8_Missense_Mutation_p.E529D	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	553					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TAGCCTTTGCCTCAATGCTTG	0.403000													9	22					3.86212e-05	4.72862e-05	0.008291	1	0
RET	5979	broad.mit.edu	37	10	43606842	43606842	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:43606842T>C	ENST00000355710.3	+	7	1683	c.1451T>C	c.(1450-1452)aTg>aCg	p.M484T	RET_ENST00000340058.5_Missense_Mutation_p.M484T	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	484					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTTCACTACATGGTGGTGGCC	0.632000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				11	27					0	0	0.008291	0	0
OR4A47	403253	broad.mit.edu	37	11	48511136	48511136	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:48511136C>A	ENST00000446524.1	+	1	868	c.792C>A	c.(790-792)ccC>ccA	p.P264P		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P264P(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						GGACCTTCCCCATTGACAAAT	0.423000													48	115					1.86277e-20	3.55394e-20	0.003610	1	0
NEB	4703	broad.mit.edu	37	2	152507197	152507197	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:152507197T>A	ENST00000397345.3	-	53	7320	c.7118A>T	c.(7117-7119)cAg>cTg	p.Q2373L	NEB_ENST00000409198.1_Missense_Mutation_p.Q2373L|NEB_ENST00000603639.1_Missense_Mutation_p.Q2373L|NEB_ENST00000604864.1_Missense_Mutation_p.Q2373L|NEB_ENST00000172853.10_Missense_Mutation_p.Q2373L|NEB_ENST00000427231.2_Missense_Mutation_p.Q2373L	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	2373					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AACCAACTCCTGACACTTCTT	0.453000													33	332					0	0	0.010818	0	0
XYLT1	64131	broad.mit.edu	37	16	17353102	17353102	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:17353102G>T	ENST00000261381.6	-	3	740	c.656C>A	c.(655-657)cCc>cAc	p.P219H		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	219					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCTGTCCCCGGGAGGCAGCAC	0.587000													28	130					5.61819e-17	1.0318e-16	0.005443	1	0
SDC2	6383	broad.mit.edu	37	8	97605770	97605770	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:97605770A>T	ENST00000302190.4	+	2	1044	c.123A>T	c.(121-123)tcA>tcT	p.S41S	SDC2_ENST00000519914.1_Silent_p.S12S|SDC2_ENST00000522911.1_Silent_p.S12S|SDC2_ENST00000518385.1_Intron	NM_002998.3	NP_002989.2	P34741	SDC2_HUMAN	syndecan 2	41						integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			breast(1)|cervix(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|stomach(2)	16	Breast(36;3.41e-05)				Sargramostim(DB00020)	AAGAAGCTTCAGGAGTGTATC	0.488000													8	28					0	0	0.003080	0	0
ANK3	288	broad.mit.edu	37	10	61846462	61846462	+	Missense_Mutation	SNP	T	T	C	rs142538212		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:61846462T>C	ENST00000280772.1	-	30	3912	c.3721A>G	c.(3721-3723)Aat>Gat	p.N1241D	ANK3_ENST00000355288.2_Missense_Mutation_p.N375D|ANK3_ENST00000503366.1_Missense_Mutation_p.N1242D|ANK3_ENST00000373827.2_Missense_Mutation_p.N1235D	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1241					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGACGCAGATTGGGTGTAGTG	0.428000													19	34					0	0	0.008871	0	0
ANK2	287	broad.mit.edu	37	4	113970948	113970948	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:113970948A>G	ENST00000357077.4	+	1	117	c.64A>G	c.(64-66)Agg>Ggg	p.R22G	ANK2_ENST00000506722.1_Intron|RP11-650J17.1_ENST00000508959.1_RNA|ANK2_ENST00000394537.3_Missense_Mutation_p.R22G|ANK2_ENST00000264366.6_Missense_Mutation_p.R22G	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	22					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGTAGTCAGAGGAGAAAAAG	0.408000													5	13					0	0	0.000602	0	0
POLQ	10721	broad.mit.edu	37	3	121212454	121212454	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:121212454C>G	ENST00000264233.5	-	15	2521	c.2393G>C	c.(2392-2394)cGg>cCg	p.R798P		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	798					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TAAGGATACCCGAACCAGGTC	0.493000								DNA polymerases (catalytic subunits)					17	14					0	0	0.004007	0	0
RPL22L1	200916	broad.mit.edu	37	3	170587948	170587948	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:170587948C>A	ENST00000295830.8	-	1	324	c.9_splice	c.e1+1	p.P3_splice	RPL22L1_ENST00000463836.1_Splice_Site_p.P3_splice	NM_001099645.1	NP_001093115.1	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	3					translation	ribosome	structural constituent of ribosome			kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	4	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GCTCACTCACCGGCGCCATCT	0.547000													10	58					2.27111e-07	3.15096e-07	0.001368	1	0
LILRA4	23547	broad.mit.edu	37	19	54850149	54850149	+	Silent	SNP	G	G	T	rs149986255	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:54850149G>T	ENST00000291759.4	-	2	114	c.58C>A	c.(58-60)Cgg>Agg	p.R20R		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	20						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GCCTGCACCCGGGTCCTGGGG	0.622000											OREG0003656	type=REGULATORY REGION|Gene=LILRA4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	24					2.79863e-10	4.38147e-10	0.004656	1	0
C9orf72	203228	broad.mit.edu	37	9	27548256	27548256	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:27548256C>A	ENST00000380003.3	-	11	1487	c.1424G>T	c.(1423-1425)cGa>cTa	p.R475L	C9orf72_ENST00000488117.1_5'UTR	NM_001256054.1|NM_018325.3	NP_001242983.1|NP_060795.1	Q96LT7	CI072_HUMAN	chromosome 9 open reading frame 72	475										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		TAGAACATCTCGTTCTTGCAC	0.403000													23	21					1.10513e-12	1.86981e-12	0.002299	1	0
SMAP1	60682	broad.mit.edu	37	6	71566579	71566579	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:71566579A>G	ENST00000370455.3	+	9	1055	c.807A>G	c.(805-807)ccA>ccG	p.P269P	SMAP1_ENST00000370452.3_Silent_p.P242P|B3GAT2_ENST00000230053.6_3'UTR|SMAP1_ENST00000316999.5_Silent_p.P242P	NM_001044305.1	NP_001037770.1	Q8IYB5	SMAP1_HUMAN	small ArfGAP 1	269					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						CCTCTGCACCAGCAGCTGCAA	0.393000													7	27					0	0	0.004482	0	0
AIRE	326	broad.mit.edu	37	21	45709916	45709916	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:45709916C>A	ENST00000291582.5	+	7	971	c.844C>A	c.(844-846)Cct>Act	p.P282T		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	282					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CGTTCCCGCCCCTCTGGCCCT	0.687000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				9	11					0.000673444	0.000759613	0.008291	1	0
KIF17	57576	broad.mit.edu	37	1	21031213	21031213	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:21031213G>A	ENST00000247986.2	-	5	1160	c.850C>T	c.(850-852)Cac>Tac	p.H284Y	KIF17_ENST00000400463.3_Missense_Mutation_p.H284Y|KIF17_ENST00000375044.1_Missense_Mutation_p.H184Y			Q9P2E2	KIF17_HUMAN	kinesin family member 17	284					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TAGGGGACGTGCTTACAGCGC	0.662000													11	77					0	0	0.001368	0	0
ITGA2B	3674	broad.mit.edu	37	17	42451767	42451767	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:42451767C>A	ENST00000262407.5	-	29	3046	c.3015G>T	c.(3013-3015)ctG>ctT	p.L1005L	ITGA2B_ENST00000353281.4_Silent_p.L971L	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	1005					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GCAGGCCACCCAGCACACCCA	0.647000													26	88					3.08376e-08	4.47719e-08	0.003330	1	0
FAM188A	80013	broad.mit.edu	37	10	15902296	15902296	+	Translation_Start_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:15902296C>A	ENST00000277632.3	-	1	223	c.3G>T	c.(1-3)atG>atT	p.M1I	FAM188A_ENST00000477891.1_5'UTR	NM_024948.2	NP_079224.1	Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	1					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						TCAGTTCGGACATGATGAGGA	0.637000													3	10					0.004672	0.0050606	0.004672	1	0
TTN	7273	broad.mit.edu	37	2	179453306	179453306	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179453306G>T	ENST00000589042.1	-	304	63370	c.63146C>A	c.(63145-63147)cCa>cAa	p.P21049Q	TTN_ENST00000342175.6_Missense_Mutation_p.P12176Q|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P11984Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P12109Q|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P19408Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P18481Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19408	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCAAGCTTGGTTCTCCAAT	0.433000													44	312					1.89013e-27	3.74323e-27	0.003610	1	0
OR51V1	283111	broad.mit.edu	37	11	5221672	5221672	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:5221672C>G	ENST00000321255.1	-	1	258	c.259G>C	c.(259-261)Gtg>Ctg	p.V87L		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGTGTACACAGTGGACAGC	0.532000													14	28					0	0	0.003163	0	0
MYLK2	85366	broad.mit.edu	37	20	30409403	30409403	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:30409403C>A	ENST00000375994.2	+	3	908	c.635C>A	c.(634-636)cCa>cAa	p.P212Q	MYLK2_ENST00000375985.4_Missense_Mutation_p.P212Q			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	212					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GAGAAAACCCCAGGCCAGGCT	0.607000													23	86					2.70639e-06	3.56497e-06	0.002299	1	0
ZNF578	147660	broad.mit.edu	37	19	53013861	53013861	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:53013861C>T	ENST00000421239.2	+	6	471	c.227C>T	c.(226-228)tCa>tTa	p.S76L		NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GAGGTCTTGTCAACAGGGCAA	0.383000													23	72					0	0	0.002780	0	0
GYPE	2996	broad.mit.edu	37	4	144797935	144797935	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:144797935G>T	ENST00000358615.4	-	3	261	c.210C>A	c.(208-210)atC>atA	p.I70I	GYPE_ENST00000437468.2_Silent_p.I70I	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)	70						integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					AAATTAAGATGATCATTCCAA	0.383000													3	18					0.004672	0.0050606	0.004672	1	0
ADCY2	108	broad.mit.edu	37	5	7784551	7784551	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:7784551C>T	ENST00000338316.4	+	19	2547	c.2458C>T	c.(2458-2460)Ctg>Ttg	p.L820L	ADCY2_ENST00000537121.1_Silent_p.L640L	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	820					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						ACTGCTTGTTCTGGGTAGACA	0.373000													10	109					0	0	0.008291	0	0
ITGA2B	3674	broad.mit.edu	37	17	42457494	42457494	+	Missense_Mutation	SNP	C	C	A	rs139770734		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:42457494C>A	ENST00000262407.5	-	17	1659	c.1628G>T	c.(1627-1629)cGg>cTg	p.R543L	ITGA2B_ENST00000353281.4_Missense_Mutation_p.R543L|ITGA2B_ENST00000377068.3_3'UTR	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	543					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGCTTCTGCCGGTCCAGCTG	0.682000													14	32					2.32078e-09	3.52735e-09	0.003163	1	0
SWT1	54823	broad.mit.edu	37	1	185191038	185191038	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:185191038G>T	ENST00000367500.4	+	15	2344	c.2179G>T	c.(2179-2181)Ggt>Tgt	p.G727C	SWT1_ENST00000367501.3_Missense_Mutation_p.G727C	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	727										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						AAAGCAGGAAGGTACTTCATT	0.373000													23	101					5.26018e-13	8.96159e-13	0.012319	1	0
PRUNE2	158471	broad.mit.edu	37	9	79325548	79325548	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:79325548T>G	ENST00000428286.1	-	8	1765	c.565A>C	c.(565-567)Aat>Cat	p.N189H	PRUNE2_ENST00000376718.3_Missense_Mutation_p.N548H			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	548					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GATGAATAATTAGACATGTTG	0.502000													8	11					0	0	0.003080	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	52					0	0	0.009096	0	0
CARD17	440068	broad.mit.edu	37	11	104970149	104970149	+	Splice_Site	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:104970149C>G	ENST00000375707.1	-	3	291		c.e3-1		CASP1_ENST00000415981.2_Intron|CARD16_ENST00000525374.1_Intron|CASP1_ENST00000598974.1_Intron|CASP1_ENST00000594519.1_Intron|CASP1_ENST00000593315.1_Intron	NM_001007232.1	NP_001007233.1			caspase recruitment domain family, member 17											breast(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	6						GATGTTGGACCTAGAGAAAGA	0.393000													13	27					0	0	0.001368	0	0
KIAA1644	85352	broad.mit.edu	37	22	44692601	44692601	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:44692601C>G	ENST00000381176.4	-	3	364	c.232G>C	c.(232-234)Gcg>Ccg	p.A78P		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	78						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TGCATCACCGCCTGGAACTCC	0.597000													38	98					0	0	0.006999	0	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720917	31720917	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:31720917T>C	ENST00000334160.4	-	1	7	c.8A>G	c.(7-9)tAc>tGc	p.Y3C		NM_181624.1	NP_853655.1	A1A580	KR231_HUMAN	keratin associated protein 23-1	3						intermediate filament				large_intestine(1)|lung(4)|prostate(1)	6						GCAGCAGTTGTAGGACATGTT	0.547000													14	61					0	0	0.002450	0	0
RDM1	201299	broad.mit.edu	37	17	34251770	34251770	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:34251770C>A	ENST00000394529.3	-	3	823	c.337G>T	c.(337-339)Gag>Tag	p.E113*	RDM1_ENST00000293273.6_Nonsense_Mutation_p.E136*|RDM1_ENST00000431884.2_Nonsense_Mutation_p.E136*|RDM1_ENST00000591402.1_Intron|RDM1_ENST00000394528.3_Nonsense_Mutation_p.E136*|RDM1_ENST00000430160.2_Nonsense_Mutation_p.E113*|RDM1_ENST00000394527.1_Intron|RDM1_ENST00000425909.3_Intron|RDM1_ENST00000419453.2_Nonsense_Mutation_p.E113*	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	136	Necessary for nuclear and nucleolar localization.				DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TCAGAAAGCTCCTGAAGCTGT	0.418000								Other identified genes with known or suspected DNA repair function					33	42					1.26612e-14	2.26008e-14	0.003271	1	0
SDK1	221935	broad.mit.edu	37	7	4249736	4249736	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:4249736G>T	ENST00000404826.2	+	38	5620	c.5481G>T	c.(5479-5481)gcG>gcT	p.A1827A	SDK1_ENST00000389531.3_Silent_p.A1807A	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1827	Fibronectin type-III 12.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCCTGCGGCGGCCAACGGCA	0.637000													26	51					3.01185e-09	4.54953e-09	0.003954	1	0
OLFML2B	25903	broad.mit.edu	37	1	161976182	161976182	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:161976182C>A	ENST00000294794.3	-	4	1051	c.628G>T	c.(628-630)Ggc>Tgc	p.G210C	OLFML2B_ENST00000367940.2_Missense_Mutation_p.G210C	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	210										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TTTTCTTTGCCTCGCTTATTC	0.448000													28	94					1.32181e-22	2.5473e-22	0.007291	1	0
HOXB1	3211	broad.mit.edu	37	17	46608020	46608020	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:46608020C>A	ENST00000239174.6	-	1	339	c.247G>T	c.(247-249)Ggg>Tgg	p.G83W	HOXB1_ENST00000577092.1_Missense_Mutation_p.G83W	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	83						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity	p.G83W(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GGAGCATACCCCGAGGGCGCG	0.652000													34	74					7.11191e-15	1.27613e-14	0.002836	1	0
TRAF7	84231	broad.mit.edu	37	16	2226101	2226101	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2226101G>A	ENST00000326181.6	+	19	1930	c.1798G>A	c.(1798-1800)Ggc>Agc	p.G600S		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	600					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GGGCCACGTGGGCACCGTGTA	0.652000													4	16					0	0	0.009096	0	0
OR8H2	390151	broad.mit.edu	37	11	55872770	55872770	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55872770G>A	ENST00000313503.1	+	1	252	c.252G>A	c.(250-252)gcG>gcA	p.A84A		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAACCTTAGCGAACTTACTGA	0.438000										HNSCC(53;0.14)			42	269					0	0	0.003610	0	0
CACNA1E	777	broad.mit.edu	37	1	181707532	181707532	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:181707532G>T	ENST00000526775.1	+	23	3690	c.3525G>T	c.(3523-3525)acG>acT	p.T1175T	CACNA1E_ENST00000357570.5_Silent_p.T1145T|CACNA1E_ENST00000367567.4_Silent_p.T801T|CACNA1E_ENST00000358338.5_Silent_p.T1126T|CACNA1E_ENST00000360108.3_Silent_p.T1175T|CACNA1E_ENST00000367570.1_Silent_p.T1194T|CACNA1E_ENST00000367573.2_Silent_p.T1194T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1194					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.T1194T(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ATGTGTTCACGGGCGTGTTCA	0.473000													108	121					1.09637e-55	2.21463e-55	0.003610	1	0
KIT	3815	broad.mit.edu	37	4	55561731	55561731	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:55561731C>T	ENST00000288135.5	+	2	218	c.121C>T	c.(121-123)Cca>Tca	p.P41S		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	41	Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ATCCATCCATCCAGGAAAATC	0.483000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				16	18					0	0	0.003163	0	0
TMEM132B	114795	broad.mit.edu	37	12	126135313	126135313	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:126135313T>A	ENST00000299308.3	+	7	1721	c.1713T>A	c.(1711-1713)cgT>cgA	p.R571R	TMEM132B_ENST00000535886.1_Silent_p.R83R	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	571						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCACAGTGCGTGTCCTCACCC	0.592000													10	30					0	0	0.010729	0	0
SRSF2	6427	broad.mit.edu	37	17	74732406	74732406	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:74732406C>T	ENST00000392485.2	-	2	675	c.503G>A	c.(502-504)aGg>aAg	p.R168K	MFSD11_ENST00000586622.1_5'UTR|RP11-318A15.7_ENST00000587459.1_Intron|SRSF2_ENST00000359995.5_Missense_Mutation_p.R168K|SRSF2_ENST00000508921.3_Missense_Mutation_p.R156K|MFSD11_ENST00000588460.1_5'UTR	NM_003016.4	NP_003007.2	Q01130	SRSF2_HUMAN	serine/arginine-rich splicing factor 2	168	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(320)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)	329						GGACTTGGACCTTCGTGCGGA	0.617000			Mis		"""MDS, CLL"""								21	104					0	0	0.002299	0	0
LAMB2	3913	broad.mit.edu	37	3	49163401	49163401	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:49163401C>T	ENST00000418109.1	-	18	2507	c.2344_splice	c.e18+1	p.L781_splice	LAMB2_ENST00000305544.4_Splice_Site_p.L781_splice	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	781					cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACACTCACGCAGGGCACCAT	0.607000													9	32					0	0	0.006214	0	0
ZNF670	93474	broad.mit.edu	37	1	247202732	247202732	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:247202732G>T	ENST00000366503.2	-	2	269	c.111C>A	c.(109-111)ttC>ttA	p.F37L		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			CCAGGTTCCTGAAGATTTCTT	0.453000													9	47					2.17888e-05	2.72201e-05	0.006214	1	0
COL12A1	1303	broad.mit.edu	37	6	75865471	75865471	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:75865471T>A	ENST00000322507.8	-	16	3659	c.3350A>T	c.(3349-3351)tAt>tTt	p.Y1117F	COL12A1_ENST00000416123.2_Missense_Mutation_p.Y1117F|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Missense_Mutation_p.Y1117F	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1117	Fibronectin type-III 8.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGTGACTTTATAACCCTTCAC	0.498000													22	83					0	0	0.002780	0	0
PABPC4L	132430	broad.mit.edu	37	4	135122082	135122082	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:135122082G>T	ENST00000529122.2	-	2	349	c.267C>A	c.(265-267)agC>agA	p.S89R	PABPC4L_ENST00000421491.3_Missense_Mutation_p.S31R	NM_001114734.1	NP_001108206.2			poly(A) binding protein, cytoplasmic 4-like											breast(1)|endometrium(2)	3						GCCCCACAGTGCTGAACTTCC	0.572000													4	2					0.00909568	0.00969341	0.009096	1	0
INS	3630	broad.mit.edu	37	11	2181169	2181169	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:2181169C>A	ENST00000397262.1	-	2	478	c.246G>T	c.(244-246)ctG>ctT	p.L82L	INS_ENST00000250971.3_Silent_p.L82L|INS_ENST00000512523.1_Silent_p.L70L|INS-IGF2_ENST00000397270.1_Intron|INS_ENST00000381330.4_Silent_p.L82L	NM_001185098.1	NP_001172027.1			insulin											haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	5		Lung NSC(207;8.94e-06)|all_epithelial(84;3.17e-05)|all_lung(207;3.67e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.14)		GGGACCCCTCCAGGGCCAAGG	0.662000													3	8					6.4e-05	7.73298e-05	0.004672	1	0
SFRP2	6423	broad.mit.edu	37	4	154707014	154707014	+	Splice_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:154707014A>T	ENST00000274063.4	-	2	868		c.e2+1			NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2						brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				TGTATTACTTACCAAAATCAT	0.318000													3	15					0	0	0.004672	0	0
REPIN1	29803	broad.mit.edu	37	7	150069097	150069097	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150069097G>T	ENST00000397281.2	+	4	1256	c.767G>T	c.(766-768)cGc>cTc	p.R256L	REPIN1_ENST00000489432.2_Missense_Mutation_p.R313L|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000425389.2_Missense_Mutation_p.R256L|REPIN1_ENST00000444957.1_Missense_Mutation_p.R256L|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000466559.1_3'UTR|REPIN1_ENST00000540729.1_Missense_Mutation_p.R256L	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	256					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTCACCGCCGCGTGCACACG	0.682000													9	51					0.00621372	0.0067052	0.006214	1	0
TOP1	7150	broad.mit.edu	37	20	39728849	39728849	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:39728849A>G	ENST00000361337.2	+	12	1379	c.1129A>G	c.(1129-1131)Atc>Gtc	p.I377V	RP1-1J6.2_ENST00000454626.1_RNA	NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	377					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	GAAGAGACGAATCATGCCCGA	0.507000			T	NUP98	AML*								10	34					0	0	0.010729	0	0
PRDM1	639	broad.mit.edu	37	6	106543577	106543577	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:106543577C>T	ENST00000369096.4	+	3	613	c.379C>T	c.(379-381)Cct>Tct	p.P127S	PRDM1_ENST00000369091.2_Missense_Mutation_p.P91S	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	127	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TGACACAGTTCCTAAGAACGC	0.393000			"""D, N, Mis, F, S"""		DLBCL								5	18					0	0	0.000602	0	0
ANKRD26	22852	broad.mit.edu	37	10	27294557	27294557	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:27294557C>A	ENST00000376087.4	-	34	5260	c.5095G>T	c.(5095-5097)Gaa>Taa	p.E1699*	ANKRD26_ENST00000376070.3_Nonsense_Mutation_p.E1256*|ANKRD26_ENST00000436985.2_Nonsense_Mutation_p.E1715*	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1698						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TGTACATATTCTCTTGATGCT	0.318000													10	54					2.17888e-05	2.72201e-05	0.006214	1	0
MRM1	79922	broad.mit.edu	37	17	34958299	34958299	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:34958299C>A	ENST00000250156.7	+	1	299	c.60C>A	c.(58-60)ttC>ttA	p.F20L		NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	20					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCCGTCATTTCTCCCATGCAG	0.677000													13	55					0.00010058	0.000119569	0.001368	1	0
LINGO2	158038	broad.mit.edu	37	9	27949889	27949889	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:27949889G>T	ENST00000379992.2	-	6	1230	c.781C>A	c.(781-783)Ctg>Atg	p.L261M	LINGO2_ENST00000308675.3_Missense_Mutation_p.L261M	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	261						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		ACAGTAGACAGATTGGTGTTG	0.463000													26	183					1.42536e-11	2.32908e-11	0.004656	1	0
XIRP2	129446	broad.mit.edu	37	2	168114542	168114542	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168114542A>T	ENST00000409728.1	+	11	1674	c.1585A>T	c.(1585-1587)Atg>Ttg	p.M529L	XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409605.1_Missense_Mutation_p.M274L|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409756.2_Missense_Mutation_p.M496L|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.M496L|XIRP2_ENST00000420519.1_Missense_Mutation_p.M529L	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAACCAAATATGTGTAAAAA	0.348000													9	43					0	0	0.004482	0	0
GRM8	2918	broad.mit.edu	37	7	126882944	126882944	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:126882944C>G	ENST00000339582.2	-	2	1123	c.315G>C	c.(313-315)acG>acC	p.T105T	GRM8_ENST00000444921.2_Silent_p.T105T|GRM8_ENST00000405249.1_Silent_p.T105T|GRM8_ENST00000358373.3_Silent_p.T105T			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	105					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCTAGAGCACGTGTCGAGGA	0.483000										HNSCC(24;0.065)			10	52					0	0	0.006214	0	0
GRIN3A	116443	broad.mit.edu	37	9	104448970	104448970	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:104448970G>T	ENST00000361820.3	-	2	1812	c.1212C>A	c.(1210-1212)acC>acA	p.T404T		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	404					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTTGGATCATGGTGGCTGTGG	0.468000													19	30					2.35188e-11	3.81764e-11	0.006122	1	0
SSH1	54434	broad.mit.edu	37	12	109200079	109200079	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:109200079C>G	ENST00000326495.5	-	9	916	c.823G>C	c.(823-825)Gag>Cag	p.E275Q	SSH1_ENST00000551165.1_Missense_Mutation_p.E275Q|SSH1_ENST00000360239.3_5'UTR|SSH1_ENST00000326470.5_Missense_Mutation_p.E286Q	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	275					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGTCTTACCTCTTTGGAAGTC	0.527000													47	78					0	0	0.003610	0	0
PKD1L2	114780	broad.mit.edu	37	16	81161599	81161599	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:81161599G>T	ENST00000533478.1	-	0	4171				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AAGAGGGCAAGAGCTTTCCTG	0.517000													5	11					0.00116845	0.00130426	0.001168	1	0
XIRP2	129446	broad.mit.edu	37	2	168102030	168102030	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168102030A>G	ENST00000409195.1	+	9	4217	c.4128A>G	c.(4126-4128)caA>caG	p.Q1376Q	XIRP2_ENST00000409273.1_Silent_p.Q1154Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.Q1376Q|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1201					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTGTCACACAAGAAGACATTC	0.363000													9	33					0	0	0.004482	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244675	49244675	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:49244675G>T	ENST00000332955.2	-	9	1362	c.815C>A	c.(814-816)gCg>gAg	p.A272E		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	272					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		CTCCGTGGTCGCCTCCCCCGG	0.562000													15	33					6.72482e-11	1.07037e-10	0.003163	1	0
IL1RL1	9173	broad.mit.edu	37	2	102965695	102965695	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:102965695T>A	ENST00000233954.1	+	10	1545	c.1274T>A	c.(1273-1275)cTa>cAa	p.L425Q		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	425	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						AGAGATATGCTACCTGGAGAA	0.413000													15	16					0	0	0.003163	0	0
TRIM72	493829	broad.mit.edu	37	16	31230632	31230632	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:31230632G>T	ENST00000322122.3	+	4	793	c.509G>T	c.(508-510)gGg>gTg	p.G170V		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	170					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						CAGTTCCGGGGGGCCGTGGGG	0.657000													9	61					4.68919e-08	6.75102e-08	0.008291	1	0
SVEP1	79987	broad.mit.edu	37	9	113217973	113217973	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:113217973A>G	ENST00000401783.2	-	22	4020	c.3684T>C	c.(3682-3684)tgT>tgC	p.C1228C	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374469.1_Silent_p.C1205C|SVEP1_ENST00000302728.8_Silent_p.C1228C	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1228	EGF-like 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGTCTGTTTCACACTTTAAGC	0.403000													5	11					0	0	0.000602	0	0
JPH2	57158	broad.mit.edu	37	20	42788499	42788499	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:42788499T>C	ENST00000372980.3	-	2	1800	c.928A>G	c.(928-930)Agt>Ggt	p.S310G		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	310					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGGAGGCCACTGGAGCGTTCG	0.672000													3	17					0	0	0.004672	0	0
RYR3	6263	broad.mit.edu	37	15	33945067	33945067	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:33945067C>A	ENST00000389232.4	+	32	4361	c.4291C>A	c.(4291-4293)Ctg>Atg	p.L1431M	RYR3_ENST00000415757.3_Missense_Mutation_p.L1431M	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1431	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGAAAGGAACTGGGCACCTG	0.557000													36	22					2.6416e-12	4.42584e-12	0.006230	1	0
MUC16	94025	broad.mit.edu	37	19	9075151	9075151	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9075151G>T	ENST00000397910.4	-	3	12498	c.12295C>A	c.(12295-12297)Cca>Aca	p.P4099T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4101	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCGCCAGGTGGACTTGTTTGC	0.507000													9	53					0.000274275	0.000316429	0.004482	1	0
ZFPM2	23414	broad.mit.edu	37	8	106813771	106813771	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:106813771T>A	ENST00000407775.2	+	8	1711	c.1461T>A	c.(1459-1461)aaT>aaA	p.N487K	RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.N218K|ZFPM2_ENST00000520492.1_Missense_Mutation_p.N355K|ZFPM2_ENST00000517361.1_Missense_Mutation_p.N355K|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	487					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTCAGCCTAATATTGGGCCTT	0.438000													49	50					0	0	0.013114	0	0
PAPPA2	60676	broad.mit.edu	37	1	176734887	176734887	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:176734887G>C	ENST00000367662.3	+	15	5401	c.4237G>C	c.(4237-4239)Ggc>Cgc	p.G1413R		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1413	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TACCTCTATAGGCCCAGGTCT	0.517000													24	85					0	0	0.003330	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763239	62763239	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:62763239G>T	ENST00000336232.2	-	7	1073	c.938C>A	c.(937-939)aCc>aAc	p.T313N	SLC22A8_ENST00000545207.1_Missense_Mutation_p.T222N|SLC22A8_ENST00000311438.8_Missense_Mutation_p.T313N|SLC22A8_ENST00000430500.2_Missense_Mutation_p.T313N|SLC22A8_ENST00000535878.1_Missense_Mutation_p.T190N	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	313					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GTCACTTGCGGTGTACTTGGC	0.597000													12	129					2.68362e-12	4.47878e-12	0.001368	1	0
ITSN1	6453	broad.mit.edu	37	21	35166694	35166694	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:35166694T>C	ENST00000381318.3	+	17	2162	c.1874T>C	c.(1873-1875)aTg>aCg	p.M625T	ITSN1_ENST00000381285.4_Missense_Mutation_p.M625T|ITSN1_ENST00000379960.5_Missense_Mutation_p.M625T|ITSN1_ENST00000399326.3_Missense_Mutation_p.M625T|ITSN1_ENST00000399338.4_Missense_Mutation_p.M625T|ITSN1_ENST00000381291.4_Missense_Mutation_p.M625T|ITSN1_ENST00000399353.1_Missense_Mutation_p.M588T|ITSN1_ENST00000399355.2_Missense_Mutation_p.M625T|ITSN1_ENST00000399349.1_Missense_Mutation_p.M625T|ITSN1_ENST00000399352.1_Missense_Mutation_p.M625T|ITSN1_ENST00000437442.2_Missense_Mutation_p.M625T|ITSN1_ENST00000399367.3_Missense_Mutation_p.M625T|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	625	KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						CAAAAGTCCATGGAGGCTGAA	0.383000													9	27					0	0	0.004482	0	0
PLCE1	51196	broad.mit.edu	37	10	96039631	96039631	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:96039631G>T	ENST00000260766.3	+	20	5392	c.4758G>T	c.(4756-4758)gaG>gaT	p.E1586D	PLCE1_ENST00000371380.2_Missense_Mutation_p.E1586D|PLCE1_ENST00000371375.1_Missense_Mutation_p.E1278D|PLCE1-AS1_ENST00000596633.1_RNA|PLCE1-AS1_ENST00000425267.3_RNA|PLCE1_ENST00000371385.3_Missense_Mutation_p.E1278D	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1586					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AAGATGAGGAGGACGAATATG	0.428000											OREG0020383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	32					2.48551e-13	4.25133e-13	0.004990	1	0
ABCC4	10257	broad.mit.edu	37	13	95714958	95714958	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:95714958C>A	ENST00000376887.4	-	26	3480	c.3366_splice	c.e26+1	p.Q1122_splice	ABCC4_ENST00000412704.1_Splice_Site_p.Q1075_splice	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1122	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ACTTGCATACCTGAGGTATGA	0.348000													24	79					3.01185e-09	4.54953e-09	0.003954	1	0
ANO4	121601	broad.mit.edu	37	12	101295493	101295493	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:101295493G>T	ENST00000538618.1	+	4	428	c.428G>T	c.(427-429)cGc>cTc	p.R143L	ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392979.3_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GTGGCAAGCCGCCCAGCGTCA	0.493000										HNSCC(74;0.22)			10	48					0.00621372	0.0067052	0.006214	1	0
KIAA1109	84162	broad.mit.edu	37	4	123161088	123161088	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:123161088A>T	ENST00000264501.4	+	29	4624	c.4251A>T	c.(4249-4251)aaA>aaT	p.K1417N	KIAA1109_ENST00000455637.1_Missense_Mutation_p.K1417N|KIAA1109_ENST00000388738.3_Missense_Mutation_p.K1417N			Q2LD37	K1109_HUMAN	KIAA1109	1417	Poly-Lys.				regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CGGGTAGAAAAAAGAAGAAAA	0.453000													9	12					0	0	0.004482	0	0
CCL13	6357	broad.mit.edu	37	17	32685094	32685094	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:32685094T>A	ENST00000225844.2	+	3	316	c.241T>A	c.(241-243)Tgg>Agg	p.W81R		NM_005408.2	NP_005399.1	Q99616	CCL13_HUMAN	chemokine (C-C motif) ligand 13	81					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				AAAGGAGAAGTGGGTCCAGAA	0.488000													11	43					0	0	0.010729	0	0
CEP112	201134	broad.mit.edu	37	17	64125897	64125897	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:64125897G>A	ENST00000392769.2	-	6	827	c.609C>T	c.(607-609)gaC>gaT	p.D203D	CEP112_ENST00000535342.2_Silent_p.D203D|CEP112_ENST00000537949.1_Silent_p.D203D	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	203						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GAGCTTCAATGTCACTATCAT	0.313000													9	53					0	0	0.004482	0	0
DAAM1	23002	broad.mit.edu	37	14	59757977	59757977	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:59757977G>T	ENST00000395125.1	+	2	249	c.226G>T	c.(226-228)Gca>Tca	p.A76S	DAAM1_ENST00000351081.1_Missense_Mutation_p.A76S|DAAM1_ENST00000556135.1_Missense_Mutation_p.A76S|DAAM1_ENST00000360909.3_Missense_Mutation_p.A76S	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	76	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AGCCATGTTTGCACTTCCAGC	0.338000													10	14					3.07112e-06	4.01769e-06	0.010729	1	0
CYP1B1	1545	broad.mit.edu	37	2	38301699	38301699	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:38301699C>A	ENST00000260630.3	-	2	1234	c.833G>T	c.(832-834)aGg>aTg	p.R278M	CYP1B1_ENST00000494864.1_Intron|CYP1B1_ENST00000407341.1_Missense_Mutation_p.R278M	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	278					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	TTCGCAGTGCCTCAAGAACTT	0.622000													3	16					6.4e-05	7.73298e-05	0.004672	1	0
DZIP1L	199221	broad.mit.edu	37	3	137786534	137786534	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:137786534G>T	ENST00000327532.2	-	14	2203	c.1841C>A	c.(1840-1842)cCg>cAg	p.P614Q		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	614						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						AGAACTGAACGGGGGCGTGCT	0.547000													5	18					1.23904e-05	1.56037e-05	0.000602	1	0
GOLGA3	2802	broad.mit.edu	37	12	133372567	133372567	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:133372567C>A	ENST00000204726.3	-	11	2898	c.2340G>T	c.(2338-2340)gcG>gcT	p.A780A	GOLGA3_ENST00000537452.1_Silent_p.A780A|GOLGA3_ENST00000545875.1_Silent_p.A780A|GOLGA3_ENST00000456883.2_Silent_p.A780A|GOLGA3_ENST00000450791.2_Silent_p.A780A	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	780					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCTGCAAAGCCGCCTCCAAGA	0.587000													12	31					2.27111e-07	3.15096e-07	0.001368	1	0
TRAF7	84231	broad.mit.edu	37	16	2226102	2226102	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2226102G>T	ENST00000326181.6	+	19	1931	c.1799G>T	c.(1798-1800)gGc>gTc	p.G600V		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	600					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GGCCACGTGGGCACCGTGTAT	0.652000													4	15					2.56e-06	3.37731e-06	0.009096	1	0
VPS13D	55187	broad.mit.edu	37	1	12374349	12374349	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:12374349C>A	ENST00000358136.3	+	30	7243	c.7113C>A	c.(7111-7113)acC>acA	p.T2371T	VPS13D_ENST00000356315.4_Silent_p.T2371T	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2371					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACAGCAGCACCACCCAAGGGT	0.507000													12	16					2.27111e-07	3.15096e-07	0.001368	1	0
PAK7	57144	broad.mit.edu	37	20	9546846	9546846	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:9546846C>A	ENST00000378429.3	-	6	1722	c.1176G>T	c.(1174-1176)tcG>tcT	p.S392S	PAK7_ENST00000378423.1_Silent_p.S392S|PAK7_ENST00000353224.5_Silent_p.S392S	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	392	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.S392S(1)		NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			AGATGTACTGCGAACTGCTCT	0.597000													17	51					2.23348e-06	2.95335e-06	0.004007	1	0
DDX18	8886	broad.mit.edu	37	2	118579481	118579481	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:118579481G>T	ENST00000263239.2	+	6	923	c.795G>T	c.(793-795)atG>atT	p.M265I	DDX18_ENST00000474694.1_3'UTR	NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	265	Helicase ATP-binding.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AACTAGCCATGCAAACCTTTG	0.438000													11	53					6.40141e-05	7.73298e-05	0.010729	1	0
SAP30L	79685	broad.mit.edu	37	5	153835567	153835567	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:153835567G>T	ENST00000297109.6	+	4	1179	c.531G>T	c.(529-531)gaG>gaT	p.E177D	SAP30L_ENST00000426761.2_Missense_Mutation_p.E131D|SAP30L_ENST00000440364.2_Missense_Mutation_p.E136D	NM_024632.5	NP_078908.1	Q9HAJ7	SP30L_HUMAN	SAP30-like	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|metal ion binding			breast(1)|lung(3)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			AGAAATCGGAGGGTGGCAAGC	0.433000													16	33					3.45872e-05	4.30836e-05	0.004007	1	0
CYTH3	9265	broad.mit.edu	37	7	6217528	6217528	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:6217528T>A	ENST00000350796.3	-	5	430	c.294A>T	c.(292-294)ccA>ccT	p.P98P		NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	98	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						CGACGTCTTCTGGGGAACTCT	0.443000													43	52					0	0	0.008740	0	0
ZNF536	9745	broad.mit.edu	37	19	30935048	30935048	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:30935048C>A	ENST00000355537.3	+	2	726	c.579C>A	c.(577-579)cgC>cgA	p.R193R		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGCGTGTGCGCGAGGAGAACC	0.692000													3	10					0.004672	0.0050606	0.004672	1	0
CXorf22	170063	broad.mit.edu	37	X	36007542	36007542	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:36007542G>T	ENST00000297866.5	+	16	2886	c.2820G>T	c.(2818-2820)gcG>gcT	p.A940A		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	940										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AAGGAAACGCGTTGAAGCTAA	0.373000													8	14					1.12685e-05	1.4264e-05	0.004482	1	0
TRANK1	9881	broad.mit.edu	37	3	36899193	36899193	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:36899193C>A	ENST00000301807.6	-	12	2135	c.238G>T	c.(238-240)Ggt>Tgt	p.G80C	TRANK1_ENST00000429976.2_Missense_Mutation_p.G630C|TRANK1_ENST00000428977.2_Missense_Mutation_p.G80C	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	630					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GATGTGTGACCAGGGGCAGTG	0.577000													27	62					6.32553e-13	1.07553e-12	0.004656	1	0
GTPBP4	23560	broad.mit.edu	37	10	1060227	1060227	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:1060227G>T	ENST00000360803.4	+	15	1665	c.1583G>T	c.(1582-1584)gGt>gTt	p.G528V	GTPBP4_ENST00000538293.1_Missense_Mutation_p.G412V|GTPBP4_ENST00000545048.1_Missense_Mutation_p.G481V	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	528					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		CGTAGTCTTGGTGTTGACATG	0.403000													9	45					1.58986e-06	2.11859e-06	0.008291	1	0
CYP3A43	64816	broad.mit.edu	37	7	99454461	99454461	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:99454461A>T	ENST00000354829.2	+	9	907	c.804A>T	c.(802-804)cgA>cgT	p.R268R	CYP3A43_ENST00000417625.1_Silent_p.R158R|CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000342499.4_Silent_p.R128R|CYP3A43_ENST00000222382.5_Silent_p.R268R|CYP3A43_ENST00000312017.5_Silent_p.R268R|CYP3A43_ENST00000415413.1_Silent_p.R57R|CYP3A43_ENST00000444905.1_Silent_p.R15R	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	268			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TCCAGCATCGAGTAGATTTCT	0.428000													50	89					0	0	0.003610	0	0
ZNF365	22891	broad.mit.edu	37	10	64148220	64148220	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:64148220G>A	ENST00000395254.3	+	3	1089	c.809G>A	c.(808-810)cGg>cAg	p.R270Q	ZNF365_ENST00000410046.3_Missense_Mutation_p.R270Q|ZNF365_ENST00000395255.3_Missense_Mutation_p.R270Q|ZNF365_ENST00000466727.1_3'UTR	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGGAAAGCCCGGCTCCAGGAC	0.498000													8	47					0	0	0.003080	0	0
DNAH9	1770	broad.mit.edu	37	17	11687751	11687751	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:11687751C>T	ENST00000262442.3	+	41	8024	c.7956C>T	c.(7954-7956)atC>atT	p.I2652I	DNAH9_ENST00000454412.2_Silent_p.I2652I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2652	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCCACTGATCGATCTGGCCC	0.512000													29	78					0	0	0.006320	0	0
LGSN	51557	broad.mit.edu	37	6	63990329	63990329	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:63990329A>T	ENST00000370657.4	-	4	1160	c.1127T>A	c.(1126-1128)cTg>cAg	p.L376Q	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	376					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ACTCTTCTTCAGGTCTTTCCT	0.458000													21	63					0	0	0.012319	0	0
CENPF	1063	broad.mit.edu	37	1	214803990	214803990	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:214803990G>C	ENST00000366955.3	+	9	1476	c.1308G>C	c.(1306-1308)caG>caC	p.Q436H		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	436	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ACGTCCTGCAGGCTGAACTGG	0.478000													17	68					0	0	0.004990	0	0
TTN	7273	broad.mit.edu	37	2	179482673	179482673	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179482673G>T	ENST00000589042.1	-	253	47629	c.47405C>A	c.(47404-47406)tCt>tAt	p.S15802Y	TTN_ENST00000342175.6_Missense_Mutation_p.S6929Y|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S6737Y|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S6862Y|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S14161Y|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S13234Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14161	Fibronectin type-III 14.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACCTGATAGAAGTCTTGTC	0.468000													85	115					1.59228e-47	3.20508e-47	0.003610	1	0
CSMD3	114788	broad.mit.edu	37	8	113293559	113293559	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:113293559C>A	ENST00000297405.5	-	59	9596	c.9352G>T	c.(9352-9354)Gga>Tga	p.G3118*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.G2949*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.G3078*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.G3048*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3118	Sushi 23.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GCTGTGGTTCCTGGGTTACCA	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	9					0.000157383	0.000184418	0.003080	1	0
ZNF41	7592	broad.mit.edu	37	X	47308150	47308150	+	Nonsense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:47308150G>C	ENST00000377065.4	-	5	1658	c.1019C>G	c.(1018-1020)tCa>tGa	p.S340*	ZNF41_ENST00000397050.2_Nonsense_Mutation_p.S350*|ZNF41_ENST00000313116.7_Nonsense_Mutation_p.S340*	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	382						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				AATGAGGTTTGATTTGAGGGT	0.413000													23	53					0	0	0.002780	0	0
C12orf49	79794	broad.mit.edu	37	12	117175674	117175674	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:117175674C>T	ENST00000261318.3	-	1	192	c.32G>A	c.(31-33)cGg>cAg	p.R11Q	C12orf49_ENST00000536380.1_Silent_p.P33P	NM_024738.1	NP_079014.1	Q9H741	CL049_HUMAN	chromosome 12 open reading frame 49	11						extracellular region				endometrium(1)|lung(1)|ovary(1)|skin(1)	4	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		CCGCAGAAGCCGGCGCCACAC	0.731000													6	8					0	0	0.001168	0	0
DDB2	1643	broad.mit.edu	37	11	47256366	47256366	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:47256366G>T	ENST00000256996.4	+	6	956	c.761G>T	c.(760-762)tGt>tTt	p.C254F	DDB2_ENST00000378603.3_Missense_Mutation_p.C190F|DDB2_ENST00000378601.3_Intron|DDB2_ENST00000378600.3_Intron	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	254					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						AACCCATGCTGTGATTGGTTC	0.537000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				11	20					4.68919e-08	6.75102e-08	0.008291	1	0
CHAT	1103	broad.mit.edu	37	10	50863149	50863149	+	Missense_Mutation	SNP	G	G	T	rs141881680		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:50863149G>T	ENST00000395562.2	+	13	1866	c.1397G>T	c.(1396-1398)cGa>cTa	p.R466L	CHAT_ENST00000395559.2_Missense_Mutation_p.R430L|CHAT_ENST00000339797.1_Missense_Mutation_p.R430L|CHAT_ENST00000455728.2_Missense_Mutation_p.R430L|CHAT_ENST00000337653.2_Missense_Mutation_p.R548L|CHAT_ENST00000351556.3_Missense_Mutation_p.R430L	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	548					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	AGGCTCCATCGAAGACTGGTG	0.507000													8	50					1.76689e-08	2.57834e-08	0.006214	1	0
IKBIP	121457	broad.mit.edu	37	12	99020244	99020244	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:99020244C>A	ENST00000299157.4	-	3	971	c.598G>T	c.(598-600)Gaa>Taa	p.E200*	IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000342502.2_Intron|IKBIP_ENST00000420861.1_Intron	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	201					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						TTTAGCCGTTCAGTGAGCAAT	0.363000													16	49					2.31682e-05	2.89014e-05	0.003163	1	0
GRIK1	2897	broad.mit.edu	37	21	30953808	30953808	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:30953808C>T	ENST00000399914.1	-	12	2325	c.1804G>A	c.(1804-1806)Gtg>Atg	p.V602M	GRIK1_ENST00000389125.3_Missense_Mutation_p.V602M|GRIK1_ENST00000535441.1_Missense_Mutation_p.V619M|GRIK1_ENST00000327783.4_Missense_Mutation_p.V617M|GRIK1_ENST00000399909.1_Missense_Mutation_p.V602M|GRIK1_ENST00000399913.1_Missense_Mutation_p.V617M|GRIK1_ENST00000309434.7_Missense_Mutation_p.V619M|GRIK1_ENST00000399907.1_Missense_Mutation_p.V617M|GRIK1_ENST00000389124.2_Missense_Mutation_p.V617M			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	617					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTGTTTTCCACCACGTCTGAG	0.448000													13	34					0	0	0.001855	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918453	51918453	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51918453G>T	ENST00000353836.5	-	7	1533	c.1312C>A	c.(1312-1314)Ctc>Atc	p.L438I	SIGLEC10_ENST00000441969.3_Missense_Mutation_p.L380I|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.L438I|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.L348I|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.L380I|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.L390I|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.L355I|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.L438I|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.L290I	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	438	Ig-like C2-type 3.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GAGAGGCTGAGAGAGACGTGC	0.657000													13	43					2.27111e-07	3.15096e-07	0.001368	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85466740	85466740	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:85466740C>T	ENST00000393217.2	+	11	2812	c.2751C>T	c.(2749-2751)caC>caT	p.H917H		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	917										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TCTGCCATCACTTGGGCACCT	0.398000													14	19					0	0	0.003163	0	0
GSTA1	2938	broad.mit.edu	37	6	52657705	52657705	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:52657705G>T	ENST00000334575.5	-	6	650	c.495C>A	c.(493-495)taC>taA	p.Y165*	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	165	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	CCTCGACGTAGTAGAGAAGTT	0.527000													5	124					0.000442599	0.00050587	0.006214	1	0
CCL17	6361	broad.mit.edu	37	16	57449018	57449018	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:57449018G>T	ENST00000219244.4	+	3	225	c.96G>T	c.(94-96)gaG>gaT	p.E32D		NM_002987.2	NP_002978.1	Q92583	CCL17_HUMAN	chemokine (C-C motif) ligand 17	32					cell-cell signaling|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|multicellular organismal development	extracellular space	chemokine activity			breast(1)|endometrium(1)|lung(2)|ovary(1)	5						TGGGCCGGGAGTGCTGCCTGG	0.607000													19	86					3.32936e-07	4.57487e-07	0.006122	1	0
SHANK1	50944	broad.mit.edu	37	19	51171708	51171708	+	Missense_Mutation	SNP	C	C	T	rs148644527	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51171708C>T	ENST00000293441.1	-	22	3527	c.3509G>A	c.(3508-3510)cGc>cAc	p.R1170H	SHANK1_ENST00000359082.3_Missense_Mutation_p.R1161H|SHANK1_ENST00000391813.1_Missense_Mutation_p.R557H|SHANK1_ENST00000391814.1_Missense_Mutation_p.R1178H	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1170					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTGGCTGCTGCGGCCGCTGCT	0.776000													8	12					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179436920	179436920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179436920G>A	ENST00000589042.1	-	326	74163	c.73939C>T	c.(73939-73941)Cga>Tga	p.R24647*	TTN_ENST00000342175.6_Nonsense_Mutation_p.R15774*|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.R15582*|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.R15707*|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.R23006*|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.R22079*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23006	Fibronectin type-III 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTAGAATTCGGCTGCCTCCA	0.468000													5	68					0	0	0.000602	0	0
PCDH17	27253	broad.mit.edu	37	13	58208940	58208940	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:58208940G>A	ENST00000377918.3	+	1	2286	c.2260G>A	c.(2260-2262)Ggg>Agg	p.G754R		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	754					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCAGCTGGGTGGGGGCAAGGG	0.557000													8	31					0	0	0.003080	0	0
SALL1	6299	broad.mit.edu	37	16	51174255	51174255	+	Missense_Mutation	SNP	C	C	A	rs80248061	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:51174255C>A	ENST00000440970.1	-	2	2018	c.1587G>T	c.(1585-1587)gaG>gaT	p.E529D	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.E626D	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	626					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCATGCCACTCTCTTCGCTTT	0.652000													6	33					0.00116845	0.00130426	0.001168	1	0
ABCA7	10347	broad.mit.edu	37	19	1043816	1043816	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:1043816C>G	ENST00000263094.6	+	10	1254	c.1023C>G	c.(1021-1023)gaC>gaG	p.D341E	ABCA7_ENST00000435683.2_Missense_Mutation_p.D203E|ABCA7_ENST00000433129.1_Missense_Mutation_p.D341E	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	341					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATGAACGACAGTTCCAATG	0.637000													23	85					0	0	0.002780	0	0
KCNH4	23415	broad.mit.edu	37	17	40315736	40315736	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:40315736G>A	ENST00000264661.3	-	13	2697	c.2365C>T	c.(2365-2367)Cag>Tag	p.Q789*	KCNH4_ENST00000607371.1_Nonsense_Mutation_p.Q789*	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	789					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTGTGGCCCTGGCCAGCCAGG	0.662000													5	13					0	0	0.000602	0	0
LST3	0	broad.mit.edu	37	12	21205070	21205070	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:21205070T>A	ENST00000381541.3	+	10	1437	c.1372T>A	c.(1372-1374)Tat>Aat	p.Y458N	SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.Y458N|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.Y411N|LST3_ENST00000540229.1_Intron																							ACCACTTTCTTATTGCAACTC	0.373000													9	38					0	0	0.004482	0	0
FAM47B	170062	broad.mit.edu	37	X	34962866	34962866	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:34962866G>T	ENST00000329357.5	+	1	1954	c.1918G>T	c.(1918-1920)Gat>Tat	p.D640Y		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	640										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AGACGTCACAGATGCATCAAA	0.383000													25	24					9.86323e-18	1.83296e-17	0.003954	1	0
INSR	3643	broad.mit.edu	37	19	7125416	7125416	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:7125416T>G	ENST00000341500.5	-	16	3139	c.3100A>C	c.(3100-3102)Atc>Ctc	p.I1034L	INSR_ENST00000302850.5_Missense_Mutation_p.I1046L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1046	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCACCCTTGATGATGTCCCTG	0.602000													11	56					0	0	0.008291	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607054	84607054	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:84607054A>C	ENST00000344803.2	+	4	1716	c.1669A>C	c.(1669-1671)Agt>Cgt	p.S557R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GTCCTTGCCTAGTACCCAACC	0.512000													21	57					0	0	0.002780	0	0
EGFR	1956	broad.mit.edu	37	7	55266471	55266471	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:55266471C>A	ENST00000275493.2	+	23	2940	c.2763C>A	c.(2761-2763)agC>agA	p.S921R	EGFR_ENST00000454757.2_Missense_Mutation_p.S868R|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Missense_Mutation_p.S876R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	921	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S921R(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCCCTGCCAGCGAGATCTCCT	0.512000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			14	94					7.93312e-07	1.07125e-06	0.002450	1	0
MIR379	494328	broad.mit.edu	37	14	101488424	101488424	+	RNA	SNP	G	G	T	rs72631818		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:101488424G>T	ENST00000362218.3	+	0	59					NR_029871.1																						ACTATGGAACGTAGGCGTTAT	0.512000													9	26					1.76689e-08	2.57834e-08	0.006214	1	0
PRMT8	56341	broad.mit.edu	37	12	3677990	3677990	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:3677990G>C	ENST00000382622.3	+	5	990	c.600G>C	c.(598-600)gtG>gtC	p.V200V	PRMT8_ENST00000452611.2_Silent_p.V191V|PRMT8_ENST00000261252.4_3'UTR	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	200					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TCAACACGGTGATCTTTGCCA	0.572000													19	76					0	0	0.008871	0	0
CROCC	9696	broad.mit.edu	37	1	17292337	17292337	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:17292337G>C	ENST00000375541.5	+	28	4594	c.4525G>C	c.(4525-4527)Ggg>Cgg	p.G1509R		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1509					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGCAGTGCGCGGGGCCCTCCG	0.672000													14	26					0	0	0.002450	0	0
CLCN4	1183	broad.mit.edu	37	X	10176261	10176261	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:10176261C>G	ENST00000380833.4	+	9	1411	c.1020C>G	c.(1018-1020)gtC>gtG	p.V340V	CLCN4_ENST00000380829.1_Intron|CLCN4_ENST00000421085.2_Silent_p.V246V	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	340						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TGCTTGGGGTCTTCGGGGGCT	0.577000													48	62					0	0	0.003610	0	0
AEBP1	165	broad.mit.edu	37	7	44146316	44146316	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:44146316C>T	ENST00000223357.3	+	2	730	c.425C>T	c.(424-426)cCc>cTc	p.P142L		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	142	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						ACCAAGAAGCCCAAGGAGAAG	0.632000													5	29					0	0	0.000602	0	0
RXRG	6258	broad.mit.edu	37	1	165380219	165380219	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:165380219T>C	ENST00000359842.5	-	5	1052	c.750A>G	c.(748-750)acA>acG	p.T250T	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	250	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CATAGGATTCTGTCTTTGGTT	0.478000													14	41					0	0	0.003163	0	0
DIAPH3	81624	broad.mit.edu	37	13	60348955	60348955	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:60348955C>T	ENST00000400324.4	-	26	3386	c.3166G>A	c.(3166-3168)Ggt>Agt	p.G1056S	DIAPH3_ENST00000267215.4_Missense_Mutation_p.G1056S|DIAPH3_ENST00000400319.1_Missense_Mutation_p.G986S|DIAPH3_ENST00000400320.1_Missense_Mutation_p.G1010S|DIAPH3_ENST00000400330.1_Missense_Mutation_p.G1056S|DIAPH3_ENST00000377908.2_Missense_Mutation_p.G1045S|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	1056					actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GTCTCATCACCCTCTGTGAAA	0.498000													17	26					0	0	0.007413	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617528	77617528	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:77617528C>T	ENST00000521891.2	+	2	1653	c.1205C>T	c.(1204-1206)cCa>cTa	p.P402L	ZFHX4_ENST00000455469.2_Missense_Mutation_p.P402L|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P402L|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.P402L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	402						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCCAAATGCCAAAGGCTGAA	0.527000										HNSCC(33;0.089)			11	12					0	0	0.008291	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													3	20					0	0	0.004672	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930790	133930790	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:133930790G>T	ENST00000298622.4	+	2	483	c.345G>T	c.(343-345)cgG>cgT	p.R115R		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGAACCAGCGGCTGCAGGCAC	0.612000													11	50					4.68919e-08	6.75102e-08	0.008291	1	0
NOS1	4842	broad.mit.edu	37	12	117685232	117685232	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:117685232C>T	ENST00000317775.6	-	18	3429	c.2744G>A	c.(2743-2745)aGg>aAg	p.R915K	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R949K	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	915	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTTCAGGATCCTCTCCCCTCC	0.562000													19	49					0	0	0.008871	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	A	rs28934576	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:7577120C>A	ENST00000420246.2	-	8	950	c.818G>T	c.(817-819)cGt>cTt	p.R273L	TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.R273L|TP53_ENST00000445888.2_Missense_Mutation_p.R273L|TP53_ENST00000359597.4_Missense_Mutation_p.R273L|TP53_ENST00000455263.2_Missense_Mutation_p.R273L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	7					3.52763e-06	4.59742e-06	0.004990	1	0
AREG	374	broad.mit.edu	37	4	75311105	75311105	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:75311105C>G	ENST00000395748.3	+	1	255	c.43C>G	c.(43-45)Ctc>Gtc	p.L15V	AREG_ENST00000502307.1_Missense_Mutation_p.L15V|AREG_ENST00000264487.2_Missense_Mutation_p.L15V	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	15					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			GGTGCTGTCGCTCTTGATACT	0.622000													3	6					0	0	0.001168	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145015899	145015899	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:145015899G>A	ENST00000369359.4	-	3	440	c.402C>T	c.(400-402)ccC>ccT	p.P134P	PDE4DIP_ENST00000530740.1_Silent_p.P134P|PDE4DIP_ENST00000493130.2_Silent_p.P63P|PDE4DIP_ENST00000478649.2_Silent_p.P63P|PDE4DIP_ENST00000313382.9_Silent_p.P63P|PDE4DIP_ENST00000369348.3_Silent_p.P134P			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTACCTGAGGGGGTTTCTCAA	0.458000			T	PDGFRB	MPD								14	601					0	0	0.002450	0	0
PCDH10	57575	broad.mit.edu	37	4	134072215	134072215	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:134072215C>A	ENST00000264360.4	+	1	1746	c.920C>A	c.(919-921)aCt>aAt	p.T307N		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	307	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		TCGCCGCGCACTGGCAGACTG	0.647000													8	48					1.58986e-06	2.11859e-06	0.008291	1	0
F5	2153	broad.mit.edu	37	1	169519150	169519150	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:169519150G>A	ENST00000367796.3	-	10	1701	c.1500C>T	c.(1498-1500)tgC>tgT	p.C500C	F5_ENST00000546081.1_3'UTR|F5_ENST00000367797.3_Silent_p.C500C			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	500	F5/8 type A 2.|Plastocyanin-like 3.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTCTTGTTAAGCACTGGGCAT	0.453000													36	46					0	0	0.003271	0	0
CDH5	1003	broad.mit.edu	37	16	66436744	66436744	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:66436744C>A	ENST00000341529.3	+	12	2175	c.2027C>A	c.(2026-2028)cCc>cAc	p.P676H	CDH5_ENST00000539168.1_Missense_Mutation_p.P115H	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	676					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		cccccgcggcccgcgcTGGAC	0.721000													8	8					0.000274275	0.000316429	0.004482	1	0
FARP1	10160	broad.mit.edu	37	13	99042248	99042248	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:99042248G>T	ENST00000376586.2	+	10	1229	c.893G>T	c.(892-894)aGt>aTt	p.S298I	FARP1_ENST00000319562.6_Missense_Mutation_p.S298I|FARP1_ENST00000595437.1_Missense_Mutation_p.S298I			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	298	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTGATGGCCAGTCGGGATTTC	0.438000													15	55					8.60227e-14	1.49216e-13	0.004007	1	0
MTMR12	54545	broad.mit.edu	37	5	32263287	32263287	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:32263287C>A	ENST00000382142.3	-	7	815	c.645G>T	c.(643-645)ctG>ctT	p.L215L	MTMR12_ENST00000280285.5_Silent_p.L215L|MTMR12_ENST00000264934.5_Silent_p.L215L	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	215	Myotubularin phosphatase.					cytoplasm	phosphatase activity	p.L215L(1)		breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGGTCCGTTCCAGTTCCCAAC	0.423000													26	153					2.12542e-12	3.57494e-12	0.006320	1	0
ITGA8	8516	broad.mit.edu	37	10	15726004	15726004	+	Splice_Site	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:15726004G>C	ENST00000378076.3	-	4	920	c.568_splice	c.e4+1	p.N189_splice		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	189					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GTTGCTTACTGTTCCGGCAAG	0.453000													9	42					0	0	0.010729	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881338	228881338	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:228881338G>C	ENST00000392056.3	-	7	4278	c.4232C>G	c.(4231-4233)cCt>cGt	p.P1411R	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P1411R	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1411						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TATTGGTACAGGGTCCTGGCA	0.453000													13	69					0	0	0.001368	0	0
DNTT	1791	broad.mit.edu	37	10	98097906	98097906	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:98097906C>A	ENST00000419175.1	+	11	1622	c.1452C>A	c.(1450-1452)ctC>ctA	p.L484L	DNTT_ENST00000371174.2_Silent_p.L485L	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	485	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		GGATATTCCTCAAAGCAGAAA	0.353000													7	23					0.00307968	0.00338706	0.003080	1	0
PARP3	10039	broad.mit.edu	37	3	51981799	51981799	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:51981799C>G	ENST00000417220.2	+	11	1808	c.1320C>G	c.(1318-1320)ttC>ttG	p.F440L	PARP3_ENST00000486510.1_3'UTR|PARP3_ENST00000398755.3_Missense_Mutation_p.F447L|PARP3_ENST00000431474.1_Missense_Mutation_p.F440L			Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	440	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCTACATGTTCCTGGGTGAGG	0.612000													25	64					0	0	0.003330	0	0
NLRP7	199713	broad.mit.edu	37	19	55449504	55449504	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:55449504A>G	ENST00000446217.1	-	7	2523	c.2121T>C	c.(2119-2121)ttT>ttC	p.F707F	NLRP7_ENST00000340844.2_Silent_p.F679F|NLRP7_ENST00000328092.5_Silent_p.F651F|NLRP7_ENST00000592784.1_Silent_p.F679F|NLRP7_ENST00000590030.1_Silent_p.F679F|NLRP7_ENST00000588756.1_Silent_p.F679F|NLRP7_ENST00000448121.2_Silent_p.F651F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	679							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCACTTCCAGAAACTTGAGGT	0.493000													14	111					0	0	0.001855	0	0
CELSR2	1952	broad.mit.edu	37	1	109795090	109795090	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:109795090G>T	ENST00000271332.3	+	1	2450	c.2389G>T	c.(2389-2391)Gac>Tac	p.D797Y		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	797	Cadherin 6.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCAGAAGTCCGACACCACCTA	0.572000													9	23					0.000442599	0.00050587	0.006214	1	0
SOX5	6660	broad.mit.edu	37	12	23687399	23687399	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:23687399G>T	ENST00000546136.1	-	14	2009	c.2007C>A	c.(2005-2007)gcC>gcA	p.A669A	SOX5_ENST00000396007.2_Silent_p.A296A|SOX5_ENST00000309359.1_Silent_p.A669A|SOX5_ENST00000537393.1_Silent_p.A647A|SOX5_ENST00000545921.1_Silent_p.A672A|SOX5_ENST00000541536.1_Silent_p.A561A|SOX5_ENST00000451604.2_Silent_p.A682A|SOX5_ENST00000381381.2_Silent_p.A561A			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	682					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						TCCCAGCCATGGCGATGGCTC	0.557000													14	21					6.31663e-08	9.04103e-08	0.003163	1	0
SOX5	6660	broad.mit.edu	37	12	23687398	23687398	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:23687398T>A	ENST00000546136.1	-	14	2010	c.2008A>T	c.(2008-2010)Atg>Ttg	p.M670L	SOX5_ENST00000396007.2_Missense_Mutation_p.M297L|SOX5_ENST00000309359.1_Missense_Mutation_p.M670L|SOX5_ENST00000537393.1_Missense_Mutation_p.M648L|SOX5_ENST00000545921.1_Missense_Mutation_p.M673L|SOX5_ENST00000541536.1_Missense_Mutation_p.M562L|SOX5_ENST00000451604.2_Missense_Mutation_p.M683L|SOX5_ENST00000381381.2_Missense_Mutation_p.M562L			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	683					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						ATCCCAGCCATGGCGATGGCT	0.557000													14	21					0	0	0.004007	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694733	153694733	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:153694733C>G	ENST00000369682.3	+	16	2989	c.2814C>G	c.(2812-2814)gaC>gaG	p.D938E		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	938	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAACGTTTGACCAAGTGAGTC	0.672000													34	82					0	0	0.003755	0	0
CEP128	145508	broad.mit.edu	37	14	81259188	81259188	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:81259188C>A	ENST00000555265.1	-	14	1851	c.1476G>T	c.(1474-1476)caG>caT	p.Q492H	CEP128_ENST00000281129.3_Missense_Mutation_p.Q492H			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	492						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TAAGCTTCCACTGCCTAATGG	0.458000													34	68					1.36161e-19	2.58346e-19	0.004289	1	0
NEB	4703	broad.mit.edu	37	2	152348631	152348631	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:152348631T>A	ENST00000397345.3	-	178	25240	c.25038A>T	c.(25036-25038)caA>caT	p.Q8346H	NEB_ENST00000397336.2_Missense_Mutation_p.Q321H|NEB_ENST00000409198.1_Missense_Mutation_p.Q6490H|NEB_ENST00000603639.1_Missense_Mutation_p.Q8346H|NEB_ENST00000604864.1_Missense_Mutation_p.Q8346H|NEB_ENST00000509223.2_Missense_Mutation_p.Q259H|RIF1_ENST00000457745.1_Intron|NEB_ENST00000498015.2_5'UTR|NEB_ENST00000172853.10_Missense_Mutation_p.Q6490H|NEB_ENST00000427231.2_Missense_Mutation_p.Q8346H	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6490					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTCCTGATCTTGGTCATTCC	0.428000													17	197					0	0	0.004990	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798068	55798068	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55798068C>T	ENST00000313555.1	+	1	174	c.174C>T	c.(172-174)ccC>ccT	p.P58P		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					TTCAAATTCCCATGTATTATT	0.338000													9	28					0	0	0.004482	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937337	82937337	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:82937337T>A	ENST00000274341.4	-	5	1893	c.1043A>T	c.(1042-1044)tAc>tTc	p.Y348F		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	348	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		TCTGAAGCAGTAGACACCATA	0.448000													24	109					0	0	0.005443	0	0
VAMP5	10791	broad.mit.edu	37	2	85818874	85818874	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:85818874G>C	ENST00000306384.4	+	2	113	c.30G>C	c.(28-30)caG>caC	p.Q10H		NM_006634.2	NP_006625.1	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	10	v-SNARE coiled-coil homology.				cell differentiation|vesicle-mediated transport	endomembrane system				NS(1)|large_intestine(3)|lung(1)	5						AGCGGTGCCAGCAGCAGGCGA	0.602000													4	46					0	0	0.009096	0	0
KIF5C	3800	broad.mit.edu	37	2	149847596	149847596	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:149847596G>T	ENST00000435030.1	+	16	2157	c.1789G>T	c.(1789-1791)Gag>Tag	p.E597*	KIF5C_ENST00000414838.2_Nonsense_Mutation_p.E502*|KIF5C_ENST00000397413.1_Nonsense_Mutation_p.E365*|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	597					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		GATGAAGTCAGAGGTCAAGTC	0.547000													12	16					2.27111e-07	3.15096e-07	0.001368	1	0
OR10A4	283297	broad.mit.edu	37	11	6898667	6898667	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6898667C>A	ENST00000379829.2	+	1	812	c.789C>A	c.(787-789)ccC>ccA	p.P263P		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATTTCCGACCCCAATCCAGTG	0.517000													14	39					9.31168e-06	1.18569e-05	0.001855	1	0
CDH10	1008	broad.mit.edu	37	5	24498512	24498512	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:24498512C>A	ENST00000264463.4	-	9	2017	c.1510G>T	c.(1510-1512)Ggg>Tgg	p.G504W	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	504	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTTACCTGCCCTGGTCTGGCA	0.388000										HNSCC(23;0.051)			34	24					8.73648e-17	1.59596e-16	0.004289	1	0
TCF23	150921	broad.mit.edu	37	2	27373134	27373134	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:27373134C>A	ENST00000296096.5	+	2	496	c.366C>A	c.(364-366)gcC>gcA	p.A122A		NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	122	Helix-loop-helix motif.				cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTCGCCGCCAGCTACATAG	0.672000													19	100					8.34094e-07	1.12455e-06	0.008871	1	0
OR2L3	391192	broad.mit.edu	37	1	248224240	248224240	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248224240C>A	ENST00000359959.3	+	1	257	c.257C>A	c.(256-258)tCt>tAt	p.S86Y	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GATTTTCTGTCTGGTAACAAG	0.443000													19	192					1.836e-18	3.43426e-18	0.003755	1	0
PEBP4	157310	broad.mit.edu	37	8	22570953	22570953	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:22570953G>T	ENST00000256404.6	-	7	705	c.614C>A	c.(613-615)aCc>aAc	p.T205N	RP11-459E5.1_ENST00000523627.1_RNA	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	205						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		AGCCTGGAGGGTTGGTGAGTC	0.572000													10	18					1.08611e-07	1.52534e-07	0.010729	1	0
ZNF257	113835	broad.mit.edu	37	19	22256291	22256291	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:22256291G>T	ENST00000594947.1	+	3	295	c.151G>T	c.(151-153)Gac>Tac	p.D51Y	ZNF257_ENST00000600162.1_Missense_Mutation_p.D51Y	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTCTAAGCCAGACCTGATCAC	0.413000													30	101					1.22384e-17	2.267e-17	0.002836	1	0
GRB14	2888	broad.mit.edu	37	2	165353989	165353989	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:165353989T>C	ENST00000263915.3	-	10	1654	c.1116A>G	c.(1114-1116)tcA>tcG	p.S372S	GRB14_ENST00000543549.1_Silent_p.S285S	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	372					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						GGGAATTCTCTGATATACTTC	0.353000													12	78					0	0	0.001368	0	0
C17orf70	80233	broad.mit.edu	37	17	79516286	79516286	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:79516286C>T	ENST00000537152.1	-	4	1421	c.896G>A	c.(895-897)aGt>aAt	p.S299N	C17orf70_ENST00000327787.8_Missense_Mutation_p.S450N	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	450					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CTGACCTGCACTCTCTGTGGT	0.607000													10	46					0	0	0.006214	0	0
TAAR1	134864	broad.mit.edu	37	6	132966951	132966951	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:132966951G>T	ENST00000275216.1	-	1	191	c.192C>A	c.(190-192)tcC>tcA	p.S64S		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	64						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	CAGTGGCCATGGAATGAATGA	0.418000													12	52					2.80697e-09	4.24753e-09	0.010729	1	0
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:33962623T>G	ENST00000389232.4	+	38	5796	c.5726T>G	c.(5725-5727)gTt>gGt	p.V1909G	RYR3_ENST00000415757.3_Missense_Mutation_p.V1909G	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.V1909G(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.473000													7	9					0	0	0.004482	0	0
EHMT1	79813	broad.mit.edu	37	9	140671225	140671225	+	Silent	SNP	G	G	A	rs139206060		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:140671225G>A	ENST00000460843.1	+	12	1974	c.1947G>A	c.(1945-1947)tcG>tcA	p.S649S	EHMT1_ENST00000334856.6_Silent_p.S618S|EHMT1_ENST00000371394.2_3'UTR|EHMT1_ENST00000462484.1_Silent_p.S649S	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	649					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		ACACCACCTCGACCGTGACAC	0.627000													8	34					0	0	0.003080	0	0
MUL1	79594	broad.mit.edu	37	1	20828626	20828626	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:20828626C>T	ENST00000264198.3	-	3	401	c.265G>A	c.(265-267)Ggg>Agg	p.G89R		NM_024544.2	NP_078820.2	Q969V5	MUL1_HUMAN	mitochondrial E3 ubiquitin protein ligase 1	89					activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(5)	11		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		TGAATTACCCCCTTGCAGTTT	0.463000													4	76					0	0	0.009096	0	0
CCDC36	339834	broad.mit.edu	37	3	49282262	49282262	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:49282262T>C	ENST00000366429.2	+	5	658	c.579T>C	c.(577-579)ccT>ccC	p.P193P	CCDC36_ENST00000451634.2_Silent_p.P183P|CCDC36_ENST00000452691.2_Intron|CCDC36_ENST00000438782.1_Intron|CCDC36_ENST00000296449.5_Intron			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	0										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GTGAGGTTCCTCACAGGGTTT	0.507000													2	11					0	0	0.004672	0	0
C11orf63	79864	broad.mit.edu	37	11	122756812	122756812	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:122756812G>T	ENST00000227349.2	+	2	552	c.255G>T	c.(253-255)ctG>ctT	p.L85L	C11orf63_ENST00000531316.1_Silent_p.L85L|C11orf63_ENST00000307257.6_Silent_p.L85L	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	85										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GGGGAAGCCTGCACGAGATGG	0.532000													20	49					1.96292e-10	3.08152e-10	0.010504	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33616005	33616005	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:33616005A>T	ENST00000504830.1	-	15	2651	c.2316T>A	c.(2314-2316)ttT>ttA	p.F772L	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.F687L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	772	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TGTCATACTGAAAGACAGTCC	0.478000										HNSCC(64;0.19)			11	125					0	0	0.008291	0	0
CSMD3	114788	broad.mit.edu	37	8	113504867	113504867	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:113504867C>A	ENST00000297405.5	-	31	5373	c.5129G>T	c.(5128-5130)gGc>gTc	p.G1710V	CSMD3_ENST00000455883.2_Missense_Mutation_p.G1606V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1670V|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1710V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1710	Sushi 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAGTCTGGTGCCATTCATTAT	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	51					2.32078e-09	3.52735e-09	0.003163	1	0
SLC16A2	6567	broad.mit.edu	37	X	73641730	73641730	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:73641730C>A	ENST00000276033.5	+	1	646	c.480C>A	c.(478-480)cgC>cgA	p.R160R	SLC16A2_ENST00000587091.1_Silent_p.R86R			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	86						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	TAGAGACCCGCGGCACCGCGC	0.697000													11	14					6.40141e-05	7.73298e-05	0.010729	1	0
UBBP4	23666	broad.mit.edu	37	17	21731178	21731178	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:21731178G>T	ENST00000584755.1	+	2	877	c.480G>T	c.(478-480)ctG>ctT	p.L160L	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Silent_p.L160L																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TGAAGACCCTGACCGGCAAGA	0.532000													15	49					3.99206e-14	7.00239e-14	0.007413	1	0
NPEPPS	9520	broad.mit.edu	37	17	45695735	45695735	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:45695735T>C	ENST00000322157.4	+	20	2552	c.2315T>C	c.(2314-2316)aTg>aCg	p.M772T	RP11-580I16.2_ENST00000582066.1_RNA|RP11-580I16.2_ENST00000582389.1_RNA|NPEPPS_ENST00000530173.1_Missense_Mutation_p.M768T|NPEPPS_ENST00000544660.1_Missense_Mutation_p.M692T	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	772					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						CAAGCAGATATGCAAGAAGAG	0.398000													7	39					0	0	0.003080	0	0
MYPN	84665	broad.mit.edu	37	10	69948766	69948766	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:69948766G>A	ENST00000358913.5	+	13	3296	c.2808G>A	c.(2806-2808)gaG>gaA	p.E936E	MYPN_ENST00000354393.2_Silent_p.E661E|MYPN_ENST00000540630.1_Silent_p.E936E	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	936						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						AACATGATGAGATCCCCACGG	0.433000													15	36					0	0	0.002450	0	0
TRIM48	79097	broad.mit.edu	37	11	55032762	55032762	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55032762C>A	ENST00000417545.2	+	2	517	c.431C>A	c.(430-432)cCc>cAc	p.P144H		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	128						intracellular	zinc ion binding	p.P128H(1)|p.P144H(1)		endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AGACACTGTCCCGCTGAGTGG	0.493000													7	33					2.17888e-05	2.72201e-05	0.006214	1	0
HRNR	388697	broad.mit.edu	37	1	152188238	152188238	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152188238G>T	ENST00000368801.2	-	3	5942	c.5867C>A	c.(5866-5868)tCt>tAt	p.S1956Y	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1956					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCAGAACCAGACCCATGTCG	0.617000													41	835					2.95478e-19	5.5939e-19	0.008740	1	0
PPIG	9360	broad.mit.edu	37	2	170493265	170493265	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:170493265A>G	ENST00000260970.3	+	14	1717	c.1497A>G	c.(1495-1497)gaA>gaG	p.E499E	PPIG_ENST00000409714.3_Silent_p.E484E|PPIG_ENST00000482772.1_3'UTR|PPIG_ENST00000448752.2_Silent_p.E499E	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	499					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ATGTTAAAGAAAAAGAAAAGC	0.323000													5	33					0	0	0.001168	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200821748	200821748	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:200821748C>T	ENST00000358823.2	+	12	3815	c.3545C>T	c.(3544-3546)aCt>aTt	p.T1182I	CAMSAP2_ENST00000413307.2_Missense_Mutation_p.T1166I|CAMSAP2_ENST00000236925.4_Missense_Mutation_p.T1193I	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	1193						cytoplasm|microtubule	protein binding										GAAAAGGAAACTCAGCTCCGG	0.398000													7	38					0	0	0.003080	0	0
ARAP2	116984	broad.mit.edu	37	4	36195269	36195269	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:36195269T>A	ENST00000303965.4	-	7	1977	c.1487_splice	c.e7-1	p.G496_splice		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	496	PH 1.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						ACATGCGTTTTCTGCAAAACA	0.259000													17	10					0	0	0.006122	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530833	80530833	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:80530833C>A	ENST00000295057.3	-	2	768	c.112G>T	c.(112-114)Ggg>Tgg	p.G38W	CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.G38W|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000466387.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	38	LRRNT.					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						TGCGGGCACCCGCTGGGGGCG	0.697000										HNSCC(69;0.2)			16	15					5.3912e-06	6.94714e-06	0.006122	1	0
IFNA7	3444	broad.mit.edu	37	9	21201913	21201913	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:21201913G>A	ENST00000239347.3	-	1	291	c.252C>T	c.(250-252)atC>atT	p.I84I		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	84					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGGTCTGCTGGATCATCTCAT	0.478000													22	148					0	0	0.003954	0	0
RYR2	6262	broad.mit.edu	37	1	237870417	237870417	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:237870417G>T	ENST00000366574.2	+	68	10066	c.9749G>T	c.(9748-9750)tGg>tTg	p.W3250L	RYR2_ENST00000542537.1_Missense_Mutation_p.W3234L|RYR2_ENST00000360064.6_Missense_Mutation_p.W3248L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3250					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTCGTTGGTGGGAGCATGGA	0.498000													12	42					5.16669e-11	8.28501e-11	0.010729	1	0
AK9	221264	broad.mit.edu	37	6	109850183	109850183	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:109850183C>A	ENST00000355283.1	-	5	1147	c.901G>T	c.(901-903)Ggg>Tgg	p.G301W	AK9_ENST00000424296.2_Intron|AK9_ENST00000341338.6_Intron					adenylate kinase 9																		gagtgagaccctgttttgaaa	0.453000													9	7					0.000442599	0.00050587	0.006214	1	0
LOC349160	349160	broad.mit.edu	37	7	136848978	136848978	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:136848978G>T	ENST00000439694.1	-	0	164				AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000599888.1_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000593789.1_RNA																							GACCACCTCTGTCCCTCTCCT	0.517000													18	33					3.32936e-07	4.57487e-07	0.006122	1	0
PDYN	5173	broad.mit.edu	37	20	1961312	1961312	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:1961312G>T	ENST00000217305.2	-	4	647	c.422C>A	c.(421-423)gCa>gAa	p.A141E	PDYN_ENST00000540134.1_Missense_Mutation_p.A141E|PDYN_ENST00000539905.1_Missense_Mutation_p.A141E|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	141					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity	p.A141V(1)		endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTCAGACTCTGCTCCCTCCCT	0.547000													14	41					3.27435e-08	4.74188e-08	0.002450	1	0
C20orf194	25943	broad.mit.edu	37	20	3299041	3299041	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:3299041T>A	ENST00000252032.9	-	17	1430	c.1363A>T	c.(1363-1365)Atg>Ttg	p.M455L	C20orf194_ENST00000453730.2_Missense_Mutation_p.M193L	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	455										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						TAGACGGCCATACAAGCCTGC	0.403000													12	23					0	0	0.001368	0	0
EPN1	29924	broad.mit.edu	37	19	56203177	56203177	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:56203177G>T	ENST00000411543.2	+	7	1625	c.1078G>T	c.(1078-1080)Gac>Tac	p.D360Y	EPN1_ENST00000085079.7_Missense_Mutation_p.D249Y|EPN1_ENST00000270460.6_Missense_Mutation_p.D274Y	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	274	8 X 3 AA repeats of [ED]-P-W.|Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CCCGACCACAGACCCCTGGGG	0.692000													25	25					1.55469e-16	2.83406e-16	0.003330	1	0
FANK1	92565	broad.mit.edu	37	10	127693614	127693614	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:127693614G>C	ENST00000368695.1	+	7	805	c.683G>C	c.(682-684)tGt>tCt	p.C228S	FANK1_ENST00000368693.1_Missense_Mutation_p.C234S|FANK1_ENST00000477963.1_3'UTR	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	234						cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				AAGGATGGCTGTGAGGTACGG	0.532000													12	63					0	0	0.010729	0	0
PZP	5858	broad.mit.edu	37	12	9348939	9348939	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:9348939G>A	ENST00000261336.2	-	10	1107	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L	PZP_ENST00000381997.2_Missense_Mutation_p.P229L	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TGCAAAAAAGGGGATTCCTTG	0.418000													7	26					0	0	0.003080	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098496	9098496	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:9098496C>A	ENST00000377424.4	-	10	1347	c.1168G>T	c.(1168-1170)Ggg>Tgg	p.G390W	SLC2A5_ENST00000535586.1_Missense_Mutation_p.G275W|SLC2A5_ENST00000536305.1_Missense_Mutation_p.G331W	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	390					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTACTGGGCCCGAGGGCATGT	0.572000													22	45					2.21704e-12	3.71813e-12	0.002780	1	0
LMF1	64788	broad.mit.edu	37	16	961035	961035	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:961035G>A	ENST00000262301.11	-	4	577	c.559C>T	c.(559-561)Ctg>Ttg	p.L187L	LMF1_ENST00000543238.1_Intron|LMF1_ENST00000568897.1_5'UTR|LMF1_ENST00000539379.1_3'UTR|LMF1_ENST00000399843.2_Silent_p.L187L	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	187						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				AGAGGGCACAGGAAGATCCCC	0.552000													11	12					0	0	0.008291	0	0
MAML1	9794	broad.mit.edu	37	5	179192625	179192625	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:179192625G>T	ENST00000292599.3	+	2	877	c.614G>T	c.(613-615)aGt>aTt	p.S205I	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	205					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTAACCCCAGTGAGTCATTT	0.537000													8	25					7.48243e-07	1.01278e-06	0.006214	1	0
WDR49	151790	broad.mit.edu	37	3	167245610	167245610	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:167245610G>A	ENST00000308378.3	-	11	1851	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	WDR49_ENST00000476376.1_Nonsense_Mutation_p.Q341*|WDR49_ENST00000453925.2_Intron|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	516										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						ATTTCTACCTGACCAAAGATC	0.383000													6	18					0	0	0.001168	0	0
CEP112	201134	broad.mit.edu	37	17	63847968	63847968	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:63847968T>A	ENST00000392769.2	-	21	2566	c.2348A>T	c.(2347-2349)gAg>gTg	p.E783V	CEP112_ENST00000541355.1_Missense_Mutation_p.E418V|CEP112_ENST00000580482.1_5'UTR|CEP112_ENST00000535342.2_Missense_Mutation_p.E783V|CEP112_ENST00000537949.1_Missense_Mutation_p.E741V	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	783						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						CTTTTTCAGCTCTATTTTCAT	0.378000													26	111					0	0	0.006320	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147869463	147869463	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:147869463C>T	ENST00000361727.3	+	18	3419	c.2903C>T	c.(2902-2904)aCc>aTc	p.T968I	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.T27I	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	968	EGF-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCCATTGCACCAGCTATGGA	0.493000										HNSCC(39;0.1)			18	94					0	0	0.008871	0	0
AK8	158067	broad.mit.edu	37	9	135739083	135739083	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:135739083G>C	ENST00000298545.3	-	4	823	c.302C>G	c.(301-303)aCc>aGc	p.T101S	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	101						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						TCTGGCTTCGGTGGCCGTATA	0.542000													8	29					0	0	0.004482	0	0
RYR2	6262	broad.mit.edu	37	1	237666694	237666694	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:237666694G>A	ENST00000366574.2	+	22	2819	c.2502G>A	c.(2500-2502)gtG>gtA	p.V834V	RYR2_ENST00000542537.1_Silent_p.V818V|RYR2_ENST00000360064.6_Silent_p.V832V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	834					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGTTGAAAGTGGAACACAGCC	0.507000													13	49					0	0	0.001368	0	0
KCNH8	131096	broad.mit.edu	37	3	19389399	19389399	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:19389399G>C	ENST00000328405.2	+	5	1019	c.753G>C	c.(751-753)ctG>ctC	p.L251L	KCNH8_ENST00000475063.1_3'UTR	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	251						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						ATGACGACCTGTCCACAACTC	0.423000													19	48					0	0	0.007413	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148080953	148080953	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:148080953C>A	ENST00000361727.3	+	22	4204	c.3688C>A	c.(3688-3690)Ccc>Acc	p.P1230T	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.P289T|CNTNAP2_ENST00000463592.2_3'UTR	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1230					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGCCACCGACCCCTGGCACCT	0.587000										HNSCC(39;0.1)			9	32					0.000442599	0.00050587	0.006214	1	0
ANKRD42	338699	broad.mit.edu	37	11	82924021	82924021	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:82924021G>T	ENST00000526731.1	+	6	1009	c.586_splice	c.e6-1	p.G196_splice	ANKRD42_ENST00000393392.2_Intron|ANKRD42_ENST00000533342.1_Intron|ANKRD42_ENST00000531895.1_Intron|RP11-727A23.7_ENST00000531869.1_RNA|ANKRD42_ENST00000393389.3_3'UTR|ANKRD42_ENST00000260047.6_Intron			Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	0										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						GCCTACGGAGGTGGCAGCCAT	0.423000													8	12					0.00448238	0.00490153	0.004482	1	0
SLC47A1	55244	broad.mit.edu	37	17	19470125	19470125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:19470125C>T	ENST00000270570.4	+	13	1215	c.1129C>T	c.(1129-1131)Cag>Tag	p.Q377*	SLC47A1_ENST00000436810.2_Nonsense_Mutation_p.Q354*|SLC47A1_ENST00000575023.1_Intron|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000395585.1_Nonsense_Mutation_p.Q377*|SLC47A1_ENST00000457293.1_Nonsense_Mutation_p.Q377*|SLC47A1_ENST00000571335.1_Nonsense_Mutation_p.Q182*	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	377						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TCTGGTGGCTCAGGTGGTTCC	0.423000													34	25					0	0	0.003755	0	0
REP15	387849	broad.mit.edu	37	12	27849605	27849605	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:27849605A>T	ENST00000310791.2	+	1	178	c.110A>T	c.(109-111)gAg>gTg	p.E37V	RP11-1060J15.4_ENST00000536922.1_RNA|RP11-1060J15.4_ENST00000536317.1_RNA	NM_001029874.1	NP_001025045.1	Q6BDI9	REP15_HUMAN	RAB15 effector protein	37						early endosome membrane				breast(1)|cervix(1)|large_intestine(2)|lung(4)|ovary(1)	9	Lung SC(9;0.0873)					AAACTGAAGGAGTACCTTGGA	0.453000													16	11					0	0	0.004007	0	0
TRPM3	80036	broad.mit.edu	37	9	73442800	73442800	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:73442800T>C	ENST00000377110.2	-	6	1179	c.936A>G	c.(934-936)caA>caG	p.Q312Q	TRPM3_ENST00000396280.5_Silent_p.Q159Q|TRPM3_ENST00000396285.1_Silent_p.Q159Q|TRPM3_ENST00000396292.4_Silent_p.Q159Q|TRPM3_ENST00000377101.1_Silent_p.Q159Q|TRPM3_ENST00000377111.2_Silent_p.Q312Q|TRPM3_ENST00000377105.1_Silent_p.Q159Q|TRPM3_ENST00000377106.1_Silent_p.Q159Q|TRPM3_ENST00000408909.2_Silent_p.Q159Q|TRPM3_ENST00000423814.3_Silent_p.Q314Q|TRPM3_ENST00000357533.2_Silent_p.Q314Q|TRPM3_ENST00000396283.1_Silent_p.Q159Q|TRPM3_ENST00000361823.5_Silent_p.Q159Q|TRPM3_ENST00000360823.2_Silent_p.Q159Q|TRPM3_ENST00000358082.3_Silent_p.Q159Q	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	312						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GCTTTTCCAGTTGTCTTCGAA	0.448000													20	71					0	0	0.010504	0	0
KIAA0556	23247	broad.mit.edu	37	16	27709764	27709764	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:27709764A>G	ENST00000261588.4	+	9	1075	c.1056A>G	c.(1054-1056)gcA>gcG	p.A352A	CTD-2049O4.1_ENST00000564893.1_RNA|KIAA0556_ENST00000567894.1_3'UTR	NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	352										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						TGGAGAACGCAGCCCTGCAGA	0.642000													12	30					0	0	0.010729	0	0
LBP	3929	broad.mit.edu	37	20	36974972	36974972	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:36974972C>A	ENST00000217407.2	+	1	214	c.53C>A	c.(52-54)aCg>aAg	p.T18K		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	18					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TTGCTGCTTACGTCCACCCCA	0.612000													12	44					4.36969e-10	6.76712e-10	0.001855	1	0
C1orf173	127254	broad.mit.edu	37	1	75037803	75037803	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:75037803G>T	ENST00000326665.5	-	14	3809	c.3591C>A	c.(3589-3591)tcC>tcA	p.S1197S	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1197	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTCCCTGCTGGACAGCTCTT	0.557000													32	78					1.62565e-12	2.73969e-12	0.012213	1	0
ITSN1	6453	broad.mit.edu	37	21	35254742	35254742	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:35254742T>A	ENST00000381318.3	+	35	4825	c.4537T>A	c.(4537-4539)Tat>Aat	p.Y1513N	ITSN1_ENST00000381285.4_Missense_Mutation_p.Y1513N|ITSN1_ENST00000399326.3_3'UTR|ITSN1_ENST00000437442.2_Missense_Mutation_p.Y1452N|ITSN1_ENST00000399367.3_Missense_Mutation_p.Y1508N|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1513	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						AAACCTGCAGTATAAAATGTA	0.433000													5	23					0	0	0.001168	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661953	77661953	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:77661953G>T	ENST00000296043.6	+	5	3580	c.2627G>T	c.(2626-2628)cGt>cTt	p.R876L		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	876					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GACAGCGGCCGTGGCCCCCAG	0.692000													3	20					0.004672	0.0050606	0.004672	1	0
NCOR1	9611	broad.mit.edu	37	17	15964934	15964934	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:15964934G>A	ENST00000268712.3	-	37	5919	c.5662C>T	c.(5662-5664)Cca>Tca	p.P1888S	NCOR1_ENST00000395857.3_Missense_Mutation_p.P472S|NCOR1_ENST00000395851.1_Intron	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1888	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TTGCCACTTGGAAAGGCTGAA	0.478000													24	64					0	0	0.002780	0	0
BRAF	673	broad.mit.edu	37	7	140476711	140476711	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:140476711C>T	ENST00000288602.6	-	13	1755		c.e13+1			NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B						activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATGGAACTTACTCCATGCCCT	0.363000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				13	69					0	0	0.001855	0	0
GPR158	57512	broad.mit.edu	37	10	25885700	25885700	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:25885700G>T	ENST00000376351.3	+	10	2486	c.2127G>T	c.(2125-2127)ttG>ttT	p.L709F	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	709						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AGCACAGCTTGGATCCAGAGG	0.473000													13	45					4.36969e-10	6.76712e-10	0.001855	1	0
ELTD1	64123	broad.mit.edu	37	1	79383622	79383622	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:79383622G>T	ENST00000370742.3	-	11	1638	c.1575C>A	c.(1573-1575)aaC>aaA	p.N525K		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	525					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AAAATCCCTTGTTGTAGATGA	0.413000													52	54					9.57592e-29	1.89862e-28	0.003610	1	0
CLSTN2	64084	broad.mit.edu	37	3	140282886	140282886	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:140282886C>A	ENST00000458420.3	+	16	2756	c.2566C>A	c.(2566-2568)Cgg>Agg	p.R856R		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	856					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GTACCGGGTCCGGATCGCCCA	0.542000										HNSCC(16;0.037)			36	72					4.3181e-19	8.15694e-19	0.002836	1	0
NAP1L1	4673	broad.mit.edu	37	12	76453598	76453598	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:76453598C>T	ENST00000261182.8	-	6	895	c.409G>A	c.(409-411)Gat>Aat	p.D137N	NAP1L1_ENST00000535020.2_Missense_Mutation_p.D137N|NAP1L1_ENST00000393263.3_Missense_Mutation_p.D137N|NAP1L1_ENST00000431879.3_Intron|NAP1L1_ENST00000552342.1_Missense_Mutation_p.D137N|NAP1L1_ENST00000544816.1_5'UTR|NAP1L1_ENST00000549596.1_Missense_Mutation_p.D137N|NAP1L1_ENST00000542344.1_Missense_Mutation_p.D96N|NAP1L1_ENST00000547773.1_Missense_Mutation_p.D74N|NAP1L1_ENST00000548044.1_Missense_Mutation_p.D96N	NM_004537.4|NM_139207.2	NP_004528.1|NP_631946.1	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	137	Asp/Glu-rich (acidic).				DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	9		Colorectal(145;0.09)				TCTTCTTCATCTGGTTTCCAT	0.289000													8	25					0	0	0.003080	0	0
COMP	1311	broad.mit.edu	37	19	18895885	18895885	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:18895885C>T	ENST00000542601.2	-	15	2025	c.1636G>A	c.(1636-1638)Ggc>Agc	p.G546S	COMP_ENST00000425807.1_Missense_Mutation_p.G526S|COMP_ENST00000222271.2_Missense_Mutation_p.G579S			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	579	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						AAGTCCACGCCATTGAAGGCA	0.592000													15	40					0	0	0.004007	0	0
DDX47	51202	broad.mit.edu	37	12	12966355	12966355	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:12966355G>T	ENST00000358007.3	+	1	76	c.54G>T	c.(52-54)gtG>gtT	p.V18V	RP11-59H1.3_ENST00000534843.1_3'UTR|DDX47_ENST00000352940.4_Silent_p.V18V	NM_016355.3	NP_057439.2	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	18						nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		AGCCGATTGTGGAAGAGGAGG	0.567000											OREG0021680	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	9					0.00024832	0.000288615	0.009096	1	0
ASNSD1	54529	broad.mit.edu	37	2	190535324	190535324	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:190535324C>G	ENST00000260952.4	+	6	2217	c.1804C>G	c.(1804-1806)Cgg>Ggg	p.R602G	ASNSD1_ENST00000607062.1_Missense_Mutation_p.R121G	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	602					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			TCTGCCCAAACGGGCCATGCA	0.408000													4	52					0	0	0.009096	0	0
C2orf53	339779	broad.mit.edu	37	2	27360302	27360302	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:27360302C>A	ENST00000335524.3	-	3	1421	c.896G>T	c.(895-897)gGc>gTc	p.G299V		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	299										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGCGGAGGCCGAAGCCGAT	0.657000													7	22					0.00198382	0.00219304	0.001984	1	0
PRDM13	59336	broad.mit.edu	37	6	100056737	100056737	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:100056737C>A	ENST00000369214.1	+	2	556	c.295C>A	c.(295-297)Ccc>Acc	p.P99T	PRDM13_ENST00000369215.4_Missense_Mutation_p.P89T	NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	89	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		TGCAGACTTACCCGGAGGACA	0.587000													10	15					0.000978159	0.00110043	0.010729	1	0
SLC29A1	2030	broad.mit.edu	37	6	44197352	44197352	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:44197352C>T	ENST00000393841.1	+	5	629	c.138C>T	c.(136-138)tcC>tcT	p.S46S	SLC29A1_ENST00000472176.1_3'UTR|SLC29A1_ENST00000371708.1_Silent_p.S46S|SLC29A1_ENST00000371731.1_Silent_p.S46S|SLC29A1_ENST00000371724.1_Silent_p.S46S|SLC29A1_ENST00000427851.2_Silent_p.S46S|SLC29A1_ENST00000371740.5_Silent_p.S46S|SLC29A1_ENST00000393844.1_Silent_p.S46S|SLC29A1_ENST00000313248.7_Silent_p.S125S|SLC29A1_ENST00000371755.3_Silent_p.S46S|SLC29A1_ENST00000371713.1_Silent_p.S46S	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	46					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	TGGACATGTCCCAGAATGTGT	0.567000													7	51					0	0	0.001984	0	0
OR5A1	219982	broad.mit.edu	37	11	59210894	59210894	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:59210894C>A	ENST00000302030.2	+	1	278	c.253C>A	c.(253-255)Ctc>Atc	p.L85I		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						TCCCAATATGCTCACTGACTT	0.478000													11	101					4.68919e-08	6.75102e-08	0.008291	1	0
DGKB	1607	broad.mit.edu	37	7	14775792	14775792	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:14775792A>G	ENST00000403951.2	-	5	615	c.196T>C	c.(196-198)Ttc>Ctc	p.F66L	DGKB_ENST00000406247.3_Missense_Mutation_p.F66L|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000407950.1_Missense_Mutation_p.F59L|DGKB_ENST00000444700.2_Missense_Mutation_p.F59L|DGKB_ENST00000402815.1_Missense_Mutation_p.F66L|DGKB_ENST00000399322.3_Missense_Mutation_p.F66L|DGKB_ENST00000258767.5_Missense_Mutation_p.F66L			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	66					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	GTCTTCATGAATAGTTTGAAA	0.338000													3	18					0	0	0.009096	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914644	94914644	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:94914644G>A	ENST00000334708.3	-	2	532	c.468C>T	c.(466-468)agC>agT	p.S156S	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	156					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GCTCCTTGATGCTGTCCAAAT	0.468000													40	94					0	0	0.007835	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798258	55798258	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55798258C>A	ENST00000313555.1	+	1	364	c.364C>A	c.(364-366)Cgc>Agc	p.R122S		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	122			R -> L (in dbSNP:rs12224086).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122C(3)		endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GGCTTATGACCGCTATGCAGC	0.458000													16	34					6.31663e-08	9.04103e-08	0.003163	1	0
SLIT3	6586	broad.mit.edu	37	5	168201290	168201290	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:168201290C>T	ENST00000519560.1	-	13	1664	c.1245G>A	c.(1243-1245)ctG>ctA	p.L415L	SLIT3_ENST00000404867.3_Silent_p.L415L|SLIT3_ENST00000332966.8_Silent_p.L415L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	415					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGATGGTCTGCAGCTTGTTGT	0.572000													48	97					0	0	0.003610	0	0
TRAV18	28665	broad.mit.edu	37	14	22471641	22471641	+	RNA	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22471641T>C	ENST00000390446.3	+	0	169																											CAGTGGAGACTCGGTTACCCA	0.453000													31	24					0	0	0.010818	0	0
FMN2	56776	broad.mit.edu	37	1	240341258	240341258	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:240341258C>A	ENST00000319653.9	+	3	2050	c.1820C>A	c.(1819-1821)cCc>cAc	p.P607H	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	607					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTTAGTCAACCCACACACTCA	0.413000													8	50					1.76689e-08	2.57834e-08	0.006214	1	0
MUC16	94025	broad.mit.edu	37	19	9069697	9069697	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9069697T>A	ENST00000397910.4	-	3	17952	c.17749A>T	c.(17749-17751)Agc>Tgc	p.S5917C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5919	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGGAGGGCTTTGCCATGAC	0.493000													20	26					0	0	0.008871	0	0
ZNF252P	286101	broad.mit.edu	37	8	146220657	146220657	+	RNA	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:146220657G>C	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						ATGAAGCATGGAGTGGAGGTG	0.418000													6	34					0	0	0.001168	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43737469	43737469	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:43737469C>A	ENST00000377564.3	+	3	732	c.339C>A	c.(337-339)ttC>ttA	p.F113L	CNTNAP3B_ENST00000276974.6_Missense_Mutation_p.F113L	NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	113	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						TCCTGATGTTCAGTGATGGTG	0.483000													22	71					5.45024e-15	9.80017e-15	0.003330	1	0
GPBP1	65056	broad.mit.edu	37	5	56542933	56542933	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:56542933A>G	ENST00000424459.3	+	9	2029	c.755A>G	c.(754-756)aAt>aGt	p.N252S	GPBP1_ENST00000538707.1_Missense_Mutation_p.N239S|GPBP1_ENST00000454432.2_Missense_Mutation_p.N252S|GPBP1_ENST00000506184.2_Missense_Mutation_p.N232S|GPBP1_ENST00000264779.6_Missense_Mutation_p.N239S|GPBP1_ENST00000514387.2_Missense_Mutation_p.N61S|GPBP1_ENST00000511209.1_Missense_Mutation_p.N239S	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		ACAAAAGAAAATAAAGTTGGA	0.348000													9	30					0	0	0.001368	0	0
RABGGTA	5875	broad.mit.edu	37	14	24737089	24737089	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:24737089A>G	ENST00000399409.3	-	12	1706	c.1223T>C	c.(1222-1224)tTc>tCc	p.F408S	RABGGTA_ENST00000560777.1_Missense_Mutation_p.F17S|RABGGTA_ENST00000216840.6_Missense_Mutation_p.F408S	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	408					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		GAGGGTCTGGAAGTACTGCAG	0.602000													3	25					0	0	0.004672	0	0
C1orf173	127254	broad.mit.edu	37	1	75037774	75037774	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:75037774C>A	ENST00000326665.5	-	14	3838	c.3620G>T	c.(3619-3621)gGg>gTg	p.G1207V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1207	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTGGCGGTGCCCTTCCTTCAG	0.597000													6	90					0.000157383	0.000184418	0.003080	1	0
KIAA1109	84162	broad.mit.edu	37	4	123246455	123246455	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:123246455A>G	ENST00000264501.4	+	65	11348	c.10975A>G	c.(10975-10977)Act>Gct	p.T3659A	KIAA1109_ENST00000455637.1_Missense_Mutation_p.T3659A|KIAA1109_ENST00000388738.3_Missense_Mutation_p.T3659A			Q2LD37	K1109_HUMAN	KIAA1109	3659					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ACCTAGAGTAACTTTTAATAT	0.323000													11	36					0	0	0.010729	0	0
CECR5	27440	broad.mit.edu	37	22	17630584	17630584	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:17630584C>T	ENST00000336737.4	-	2	203	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	CECR5_ENST00000480451.1_5'UTR|CECR5_ENST00000399852.3_Intron|CECR5_ENST00000155674.5_Missense_Mutation_p.G30S	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	60							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				ACTCTGTGGCCCCGCACAAGC	0.532000													17	47					0	0	0.007413	0	0
MRGPRF	116535	broad.mit.edu	37	11	68777349	68777349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:68777349C>T	ENST00000309099.6	-	2	403	c.21G>A	c.(19-21)tgG>tgA	p.W7*	MRGPRF_ENST00000441623.1_Nonsense_Mutation_p.W7*|MRGPRF_ENST00000320913.6_Nonsense_Mutation_p.W7*	NM_145015.4	NP_659452.3	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	7						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|lung(4)	7			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GATGGGCCTCCCAGGAGCAGT	0.672000													10	39					0	0	0.006214	0	0
FRG1B	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D|FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													3	51					0	0	0.000602	0	0
TRAV3	28690	broad.mit.edu	37	14	22192451	22192451	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22192451G>T	ENST00000390425.2	+	0	402																											GGATAACCTGGTTAAAGGCAG	0.458000													17	25					8.60227e-14	1.49216e-13	0.004007	1	0
VWC2	375567	broad.mit.edu	37	7	49842402	49842402	+	Nonsense_Mutation	SNP	C	C	A	rs147623371		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:49842402C>A	ENST00000340652.3	+	3	1348	c.792C>A	c.(790-792)taC>taA	p.Y264*		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	264	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space		p.Y264Y(1)		cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						ACCCTGTGTACGAGCCTGATC	0.572000													10	74					4.68919e-08	6.75102e-08	0.008291	1	0
NBEA	26960	broad.mit.edu	37	13	35615209	35615209	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:35615209G>T	ENST00000540320.1	+	2	968	c.434G>T	c.(433-435)cGa>cTa	p.R145L	NBEA_ENST00000379939.2_Missense_Mutation_p.R145L|NBEA_ENST00000310336.4_Missense_Mutation_p.R145L|NBEA_ENST00000400445.3_Missense_Mutation_p.R145L			Q8NFP9	NBEA_HUMAN	neurobeachin	145						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCCATTCTACGAAAAAGTGTT	0.408000													27	48					1.33986e-20	2.55914e-20	0.004656	1	0
HIVEP3	59269	broad.mit.edu	37	1	42045856	42045856	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:42045856G>T	ENST00000372584.1	-	3	5627	c.4613C>A	c.(4612-4614)tCt>tAt	p.S1538Y	HIVEP3_ENST00000247584.5_Missense_Mutation_p.S1538Y|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S1538Y|HIVEP3_ENST00000429157.2_Missense_Mutation_p.S1538Y	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1538					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGTTTGCCAGATGGCTGGGG	0.547000													8	72					0.00307968	0.00338706	0.003080	1	0
PGAP1	80055	broad.mit.edu	37	2	197705997	197705997	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:197705997G>A	ENST00000354764.3	-	27	2844	c.2730C>T	c.(2728-2730)ttC>ttT	p.F910F		NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1	910					attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						AAAGAGGAATGAAGACAAAGC	0.378000													4	43					0	0	0.009096	0	0
POLQ	10721	broad.mit.edu	37	3	121187155	121187155	+	Missense_Mutation	SNP	C	C	A	rs146701093	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:121187155C>A	ENST00000264233.5	-	23	6970	c.6842G>T	c.(6841-6843)gGc>gTc	p.G2281V		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2281					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		CACCTACCTGCCCATGGGAAG	0.348000								DNA polymerases (catalytic subunits)					21	64					5.26018e-13	8.96159e-13	0.012319	1	0
JPH3	57338	broad.mit.edu	37	16	87678336	87678336	+	Silent	SNP	C	C	G	rs112449440		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:87678336C>G	ENST00000284262.2	+	2	1097	c.855C>G	c.(853-855)acC>acG	p.T285T		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	285					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding	p.T285T(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCACCACCACCGAGACCTACG	0.672000													15	45					0	0	0.004990	0	0
MYO5B	4645	broad.mit.edu	37	18	47527634	47527634	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:47527634G>A	ENST00000285039.7	-	5	902	c.603C>T	c.(601-603)ccC>ccT	p.P201P		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	201	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCTCCATGATGGGACTGGATG	0.587000													11	59					0	0	0.010729	0	0
DCC	1630	broad.mit.edu	37	18	50866234	50866234	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:50866234G>A	ENST00000442544.2	+	15	2932	c.2316G>A	c.(2314-2316)gtG>gtA	p.V772V	DCC_ENST00000412726.1_Silent_p.V620V|DCC_ENST00000581580.1_Silent_p.V427V	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	772	Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGAGACAGTGCGTGTGGACA	0.418000													8	37					0	0	0.004482	0	0
CXorf22	170063	broad.mit.edu	37	X	35971832	35971832	+	Missense_Mutation	SNP	C	C	G	rs137975595	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:35971832C>G	ENST00000297866.5	+	7	1236	c.1170C>G	c.(1168-1170)atC>atG	p.I390M		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	390										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						ATAAAACCATCAAAAGTAAGT	0.294000													5	13					0	0	0.000602	0	0
GPATCH1	55094	broad.mit.edu	37	19	33597774	33597774	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:33597774G>T	ENST00000170564.2	+	10	1568	c.1254G>T	c.(1252-1254)cgG>cgT	p.R418R		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	418						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					CCTCCAAACGGGCTGAGTTGC	0.463000													14	17					1.5842e-08	2.33354e-08	0.001855	1	0
MACF1	23499	broad.mit.edu	37	1	39854322	39854322	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:39854322G>C	ENST00000564288.1	+	58	16585	c.15808G>C	c.(15808-15810)Gat>Cat	p.D5270H	MACF1_ENST00000289893.4_Missense_Mutation_p.D3710H|MACF1_ENST00000361689.2_Missense_Mutation_p.D3208H|MACF1_ENST00000539005.1_Missense_Mutation_p.D3187H|MACF1_ENST00000317713.7_Missense_Mutation_p.D3208H|MACF1_ENST00000567887.1_Missense_Mutation_p.D5307H|MACF1_ENST00000545844.1_Missense_Mutation_p.D3208H|MACF1_ENST00000372915.3_Missense_Mutation_p.D5275H			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5275					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACAATTAGCAGATTTTAAAGT	0.408000													7	45					0	0	0.003080	0	0
OR5L1	219437	broad.mit.edu	37	11	55578958	55578958	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55578958T>A	ENST00000333973.2	+	1	105	c.16T>A	c.(16-18)Tgc>Agc	p.C6S		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				CAAGGAAAACTGCACCACTGT	0.398000													16	124					0	0	0.009535	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698695	111698695	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:111698695C>A	ENST00000340433.2	+	1	969	c.739C>A	c.(739-741)Ccc>Acc	p.P247T		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	247							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						CCTCTTTAGCCCCACAGATCC	0.552000													37	63					3.76114e-14	6.62438e-14	0.004289	1	0
FAT1	2195	broad.mit.edu	37	4	187627857	187627857	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:187627857G>A	ENST00000441802.2	-	2	3334	c.3125C>T	c.(3124-3126)aCa>aTa	p.T1042I		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1042	Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTCTTTCACTGTCCCCTTTTC	0.478000										HNSCC(5;0.00058)			14	78					0	0	0.002450	0	0
MXRA5	25878	broad.mit.edu	37	X	3241306	3241306	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:3241306G>A	ENST00000217939.6	-	5	2574	c.2420C>T	c.(2419-2421)aCc>aTc	p.T807I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	807						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGGACTTGTGGTTTTAATCAA	0.478000													20	33					0	0	0.012319	0	0
SAMD9	54809	broad.mit.edu	37	7	92732038	92732038	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:92732038G>A	ENST00000379958.2	-	3	3642	c.3373C>T	c.(3373-3375)Caa>Taa	p.Q1125*		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1125						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGTAGACTTGACCCAGTGTA	0.358000													40	92					0	0	0.009718	0	0
ZNF416	55659	broad.mit.edu	37	19	58084093	58084093	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:58084093T>G	ENST00000196489.3	-	4	1401	c.1179A>C	c.(1177-1179)caA>caC	p.Q393H		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		GGCTGAAGCTTTGTCTGAATA	0.453000													28	21					0	0	0.008361	0	0
USP7	7874	broad.mit.edu	37	16	9009313	9009313	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:9009313C>A	ENST00000344836.4	-	9	1174	c.976G>T	c.(976-978)Ggc>Tgc	p.G326C	USP7_ENST00000535863.1_Missense_Mutation_p.G227C|USP7_ENST00000381886.4_Missense_Mutation_p.G310C	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	326					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						ACCATTTTGCCGCGGAATAAT	0.343000													14	34					4.7546e-09	7.13813e-09	0.004007	1	0
NRG3	10718	broad.mit.edu	37	10	84733613	84733613	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:84733613C>A	ENST00000372142.2	+	8	965	c.691C>A	c.(691-693)Cag>Aag	p.Q231K	NRG3_ENST00000372141.2_Missense_Mutation_p.Q452K|NRG3_ENST00000545131.1_Missense_Mutation_p.Q102K|NRG3_ENST00000556918.1_Missense_Mutation_p.Q282K|NRG3_ENST00000404547.1_Missense_Mutation_p.Q452K|NRG3_ENST00000537893.1_Missense_Mutation_p.Q102K|NRG3_ENST00000404576.2_Missense_Mutation_p.Q256K	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	452	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TGTCGGCCCCCAGTCATTCCC	0.502000													18	37					2.35188e-11	3.81764e-11	0.006122	1	0
APOB	338	broad.mit.edu	37	2	21227239	21227239	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:21227239T>G	ENST00000233242.1	-	28	12116	c.11989A>C	c.(11989-11991)Atc>Ctc	p.I3997L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3997					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAGGTGGAGATGCCTTTCTTG	0.502000													36	32					0	0	0.004289	0	0
IRS4	8471	broad.mit.edu	37	X	107976307	107976307	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:107976307G>A	ENST00000372129.2	-	1	3344	c.3268C>T	c.(3268-3270)Caa>Taa	p.Q1090*		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1090						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						AAGAAACTTTGAGAACGGCTT	0.567000													5	86					0	0	0.001368	0	0
MYH2	4620	broad.mit.edu	37	17	10426462	10426462	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:10426462A>T	ENST00000245503.5	-	39	6002	c.5618T>A	c.(5617-5619)tTg>tAg	p.L1873*	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Nonsense_Mutation_p.L1873*|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1873					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTTATCTACCAAATCTTGAAG	0.323000													8	20					0	0	0.006214	0	0
TRPM8	79054	broad.mit.edu	37	2	234879034	234879034	+	Silent	SNP	G	G	T	rs139854519		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:234879034G>T	ENST00000324695.4	+	17	2359	c.2319G>T	c.(2317-2319)tcG>tcT	p.S773S	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	773						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TCCTGTACTCGCTGGTCTTTG	0.562000													24	133					3.6726e-16	6.67358e-16	0.003954	1	0
OR4M2	390538	broad.mit.edu	37	15	22368783	22368783	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:22368783G>T	ENST00000332663.2	+	1	306	c.208G>T	c.(208-210)Gat>Tat	p.D70Y	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCCTTCCTTGATATTTGGTA	0.418000													85	280					2.56433e-40	5.15564e-40	0.003610	1	0
ASTN1	460	broad.mit.edu	37	1	176857216	176857216	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:176857216G>C	ENST00000367654.2	-	18	3102	c.3089C>G	c.(3088-3090)cCa>cGa	p.P1030R	ASTN1_ENST00000424564.2_Missense_Mutation_p.P1022R|ASTN1_ENST00000361833.2_Missense_Mutation_p.P1022R|ASTN1_ENST00000367657.3_Missense_Mutation_p.P1022R			O14525	ASTN1_HUMAN	astrotactin 1	1030	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CACAGGCTGTGGGAGAGGCGC	0.502000													3	52					0	0	0.004672	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73066625	73066625	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:73066625C>A	ENST00000263674.3	+	4	3851	c.3501C>A	c.(3499-3501)aaC>aaA	p.N1167K		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1167	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						ATATCGATAACTTCCTCAATG	0.552000													12	43					3.07112e-06	4.01769e-06	0.010729	1	0
COL9A1	1297	broad.mit.edu	37	6	71004241	71004241	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:71004241C>T	ENST00000357250.6	-	5	483	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	COL9A1_ENST00000370496.3_Missense_Mutation_p.E109K	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	109	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GAGTATTCTTCAGGCAGTCCA	0.393000													18	59					0	0	0.007413	0	0
PLAGL2	5326	broad.mit.edu	37	20	30785203	30785203	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:30785203C>T	ENST00000246229.4	-	3	807	c.543G>A	c.(541-543)cgG>cgA	p.R181R		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	181						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGCCTGCTACCCGGCGTGAGT	0.617000													5	12					0	0	0.001168	0	0
IGLV3-19	28797	broad.mit.edu	37	22	23063423	23063423	+	RNA	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:23063423G>A	ENST00000390309.2	+	0	170																											ATGCCAAGGAGACAGCCTCAG	0.532000													4	24					0	0	0.009096	0	0
ENOX1	55068	broad.mit.edu	37	13	43934144	43934144	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:43934144C>T	ENST00000261488.6	-	7	1009	c.432G>A	c.(430-432)gtG>gtA	p.V144V	ENOX1_ENST00000412891.1_Silent_p.V144V|ENOX1_ENST00000482207.1_5'UTR|ENOX1_ENST00000540032.1_5'UTR	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	144	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CTCCGACAAACACGGTCTTAC	0.378000													8	19					0	0	0.003080	0	0
OR8J3	81168	broad.mit.edu	37	11	55904431	55904431	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55904431A>C	ENST00000301529.1	-	1	763	c.764T>G	c.(763-765)aTg>aGg	p.M255R		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					CATAAATAGCATTGTCCCATA	0.428000													10	74					0	0	0.008291	0	0
DTX2	113878	broad.mit.edu	37	7	76112351	76112351	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:76112351C>T	ENST00000324432.5	+	5	1305	c.795C>T	c.(793-795)aaC>aaT	p.N265N	DTX2_ENST00000446820.2_Silent_p.N265N|DTX2_ENST00000446600.1_Silent_p.N174N|DTX2_ENST00000430490.2_Silent_p.N265N|DTX2_ENST00000307569.8_Silent_p.N265N|DTX2_ENST00000413936.2_Silent_p.N265N	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	265					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						ACACCACCAACGCCTGGGGCG	0.672000													12	176					0	0	0.001368	0	0
ICK	22858	broad.mit.edu	37	6	52871145	52871145	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:52871145A>G	ENST00000356971.3	-	14	2201	c.1712T>C	c.(1711-1713)gTa>gCa	p.V571A	ICK_ENST00000350082.5_Missense_Mutation_p.V571A	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	571					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TGCTAGGTGTACCCTCTGCAT	0.413000													4	56					0	0	0.009096	0	0
GPR114	221188	broad.mit.edu	37	16	57600520	57600520	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:57600520A>T	ENST00000340339.4	+	7	1079	c.556A>T	c.(556-558)Acc>Tcc	p.T186S	GPR114_ENST00000349457.3_Missense_Mutation_p.T186S|GPR114_ENST00000394361.4_3'UTR	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	186	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						GGAAGGCTACACCCTGACCTG	0.617000													24	46					0	0	0.002780	0	0
RGS7	6000	broad.mit.edu	37	1	240969580	240969580	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:240969580C>G	ENST00000366565.1	-	15	1510	c.1129G>C	c.(1129-1131)Gta>Cta	p.V377L	RGS7_ENST00000366564.1_Missense_Mutation_p.V377L|RGS7_ENST00000348120.2_Missense_Mutation_p.V324L|RGS7_ENST00000401882.1_Missense_Mutation_p.V324L|RGS7_ENST00000407727.1_Missense_Mutation_p.V377L|RGS7_ENST00000446183.2_Missense_Mutation_p.V293L|RGS7_ENST00000366563.1_Missense_Mutation_p.V377L|RGS7_ENST00000331110.7_Missense_Mutation_p.V351L|RGS7_ENST00000366562.4_Missense_Mutation_p.V377L	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	377	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CTTGAGGGTACTTCTTTAATA	0.453000													35	50					0	0	0.002836	0	0
SLC8A3	6547	broad.mit.edu	37	14	70527586	70527586	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:70527586C>A	ENST00000381269.2	-	3	2608	c.1855G>T	c.(1855-1857)Ggt>Tgt	p.G619C	SLC8A3_ENST00000533899.1_5'UTR|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000528359.1_Intron|SLC8A3_ENST00000356921.2_Missense_Mutation_p.G619C|SLC8A3_ENST00000216568.7_5'UTR|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000357887.3_Intron|SLC8A3_ENST00000534137.1_Missense_Mutation_p.G619C	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	619	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTCGGTTCACCAAGGGCAATG	0.353000													14	31					0.000308642	0.0003556	0.003163	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156906634	156906634	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:156906634T>G	ENST00000368194.3	-	40	5643	c.4604A>C	c.(4603-4605)cAt>cCt	p.H1535P	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.H1495P|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.H911P|ARHGEF11_ENST00000487682.1_5'UTR	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1495					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCCAGTTCATGGCTGTTCCT	0.582000													23	103					0	0	0.002299	0	0
HEATR5B	54497	broad.mit.edu	37	2	37304053	37304053	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:37304053C>A	ENST00000233099.5	-	4	543		c.e4+1		HEATR5B_ENST00000354531.2_Splice_Site	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B								binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GTAAAACTTACCTCTGCACTT	0.358000													21	7					8.10497e-08	1.15622e-07	0.010504	1	0
LAMA4	3910	broad.mit.edu	37	6	112462121	112462121	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:112462121C>A	ENST00000230538.7	-	22	3214	c.2817G>T	c.(2815-2817)gtG>gtT	p.V939V	LAMA4_ENST00000424408.2_Silent_p.V932V|LAMA4_ENST00000389463.4_Silent_p.V932V|LAMA4_ENST00000522006.1_Silent_p.V932V	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	939	Laminin G-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATGTTTTCCCACCCTATTGA	0.343000													13	35					0.00136819	0.00152426	0.001368	1	0
OCA2	4948	broad.mit.edu	37	15	28200349	28200349	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:28200349C>T	ENST00000354638.3	-	17	1952	c.1797G>A	c.(1795-1797)caG>caA	p.Q599Q	OCA2_ENST00000353809.5_Silent_p.Q575Q|OCA2_ENST00000382996.2_Silent_p.Q599Q	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	599					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TTTTGTCCTCCTGTGAGATCT	0.483000									Oculocutaneous Albinism				36	23					0	0	0.009718	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160253760	160253760	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:160253760A>T	ENST00000264431.4	+	11	1982	c.1563A>T	c.(1561-1563)aaA>aaT	p.K521N		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	521					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGAACAAAAAAAGTAAAGCCA	0.408000													5	27					0	0	0.000602	0	0
TACC2	10579	broad.mit.edu	37	10	123970198	123970198	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:123970198G>T	ENST00000369005.1	+	9	6598	c.6258G>T	c.(6256-6258)tcG>tcT	p.S2086S	TACC2_ENST00000453444.2_Silent_p.S2090S|TACC2_ENST00000369004.3_Silent_p.S164S|TACC2_ENST00000515603.1_Silent_p.S2041S|TACC2_ENST00000358010.1_Silent_p.S232S|TACC2_ENST00000260733.3_Silent_p.S164S|TACC2_ENST00000515273.1_Silent_p.S2090S|TACC2_ENST00000513429.1_Silent_p.S232S|TACC2_ENST00000360561.3_Silent_p.S164S|TACC2_ENST00000334433.3_Silent_p.S2086S|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000368999.1_Silent_p.S164S	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2086						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGTCCCGGTCGCTCAGCCTGC	0.577000													9	38					7.48243e-07	1.01278e-06	0.006214	1	0
SH3GL3	6457	broad.mit.edu	37	15	84245427	84245427	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:84245427G>T	ENST00000324537.5	+	9	1074	c.582G>T	c.(580-582)gcG>gcT	p.A194A	SH3GL3_ENST00000427482.2_Silent_p.A186A|SH3GL3_ENST00000535412.1_Silent_p.A186A|SH3GL3_ENST00000434347.1_Silent_p.A194A			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	186	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						TCAGACAAGCGGTAGAAAAAT	0.358000													9	10					0.000274275	0.000316429	0.004482	1	0
EGLN2	112398	broad.mit.edu	37	19	41312536	41312536	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:41312536G>T	ENST00000593726.1	+	2	1948	c.920G>T	c.(919-921)tGc>tTc	p.C307F	EGLN2_ENST00000406058.2_Missense_Mutation_p.C307F|EGLN2_ENST00000303961.4_Missense_Mutation_p.C307F|RAB4B-EGLN2_ENST00000594136.1_3'UTR|CTC-490E21.12_ENST00000601627.1_Intron|EGLN2_ENST00000594140.1_Missense_Mutation_p.C25F			Q96KS0	EGLN2_HUMAN	egl-9 family hypoxia-inducible factor 2	307	Fe2OG dioxygenase.				cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	GATGGGCGCTGCATCACCTGT	0.632000											OREG0025478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	39					4.3838e-07	5.98551e-07	0.001855	1	0
HOXB1	3211	broad.mit.edu	37	17	46606917	46606917	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:46606917T>G	ENST00000239174.6	-	2	990	c.898A>C	c.(898-900)Acc>Ccc	p.T300P	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	300						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTTCAGGAGGTGACAGAGCTG	0.662000													10	39					0	0	0.001368	0	0
GLG1	2734	broad.mit.edu	37	16	74640625	74640625	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:74640625G>C	ENST00000422840.2	-	1	367	c.368C>G	c.(367-369)aCc>aGc	p.T123S	GLG1_ENST00000447066.2_Missense_Mutation_p.T123S|GLG1_ENST00000205061.5_Missense_Mutation_p.T123S	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	123						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						GCACACGCGGGTCACGTCCTC	0.716000													10	38					0	0	0.010729	0	0
DNAJC8	22826	broad.mit.edu	37	1	28527766	28527766	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:28527766C>A	ENST00000263697.4	-	9	781	c.755G>T	c.(754-756)cGt>cTt	p.R252L	DNAJC8_ENST00000489277.1_5'UTR	NM_014280.2	NP_055095.2	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	252					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		CGGTCACTCACGTTGCTCCAT	0.512000													20	106					1.96292e-10	3.08152e-10	0.010504	1	0
MYH6	4624	broad.mit.edu	37	14	23871912	23871912	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:23871912G>T	ENST00000405093.3	-	11	1066	c.996C>A	c.(994-996)gcC>gcA	p.A332A	MYH6_ENST00000356287.3_Silent_p.A332A	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	332	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCACATCGGTGGCCATGAGCT	0.632000													9	40					0.000274275	0.000316429	0.004482	1	0
CSRNP3	80034	broad.mit.edu	37	2	166533059	166533059	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:166533059T>A	ENST00000314499.7	+	6	1022	c.646T>A	c.(646-648)Tgc>Agc	p.C216S	CSRNP3_ENST00000409420.1_Missense_Mutation_p.C248S|CSRNP3_ENST00000342316.4_Missense_Mutation_p.C216S	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	216	Cys-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						TGGCTGTGACTGCCGAGTGTT	0.542000													9	78					0	0	0.004482	0	0
KCNJ10	3766	broad.mit.edu	37	1	160012258	160012258	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:160012258C>G	ENST00000368089.3	-	2	291	c.65G>C	c.(64-66)gGc>gCc	p.G22A		NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	22						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TATCCCTGGGCCCATTAGGGG	0.542000													8	62					0	0	0.004482	0	0
CPSF1	29894	broad.mit.edu	37	8	145622131	145622131	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:145622131T>C	ENST00000349769.3	-	24	2700	c.2606A>G	c.(2605-2607)cAa>cGa	p.Q869R		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	869					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			AAGCAGCTCTTGGTCCACATG	0.612000													11	12					0	0	0.001368	0	0
STK10	6793	broad.mit.edu	37	5	171481639	171481639	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:171481639G>T	ENST00000176763.5	-	17	2929	c.2586C>A	c.(2584-2586)caC>caA	p.H862Q		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	862	Gln-rich.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTGGTTCTCGTGTTTCTGCT	0.652000													25	86					4.72057e-08	6.79051e-08	0.003954	1	0
SSH1	54434	broad.mit.edu	37	12	109182873	109182873	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:109182873C>A	ENST00000326495.5	-	15	2134	c.2041G>T	c.(2041-2043)Gcc>Tcc	p.A681S	SSH1_ENST00000360239.3_Missense_Mutation_p.A369S	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	681					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGTAGGAAGGCTGGCTGGGTG	0.657000													9	14					0.000442599	0.00050587	0.006214	1	0
TRANK1	9881	broad.mit.edu	37	3	36896947	36896947	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:36896947C>G	ENST00000301807.6	-	12	4381	c.2484G>C	c.(2482-2484)tcG>tcC	p.S828S	TRANK1_ENST00000429976.2_Silent_p.S1378S|TRANK1_ENST00000428977.2_Silent_p.S828S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1378					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCCTGAGCTTCGACAGCCTCC	0.493000													38	69					0	0	0.003755	0	0
NPR3	4883	broad.mit.edu	37	5	32739067	32739067	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:32739067T>A	ENST00000265074.8	+	3	1333	c.990T>A	c.(988-990)ccT>ccA	p.P330P	NPR3_ENST00000415167.2_Silent_p.P330P|NPR3_ENST00000415685.2_Silent_p.P114P|NPR3_ENST00000434067.2_Silent_p.P114P	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	330					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	CAGTGAAACCTGAGTTTGAGA	0.448000													19	119					0	0	0.006122	0	0
ADCY2	108	broad.mit.edu	37	5	7414860	7414860	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:7414860G>T	ENST00000338316.4	+	2	474	c.385G>T	c.(385-387)Ggc>Tgc	p.G129C		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	129					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GTGTTTTGGAGGCACCGTCTC	0.443000													46	79					1.61572e-30	3.21462e-30	0.010771	1	0
C9orf171	389799	broad.mit.edu	37	9	135357749	135357749	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:135357749C>T	ENST00000343036.2	+	2	296	c.248C>T	c.(247-249)gCg>gTg	p.A83V	C9orf171_ENST00000393216.2_Intron|C9orf171_ENST00000393215.3_Intron	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	83								p.A83E(1)		large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						GACTCCTCAGCGGTGCAGAAA	0.493000													14	25					0	0	0.003163	0	0
RGS18	64407	broad.mit.edu	37	1	192150512	192150512	+	Missense_Mutation	SNP	G	G	T	rs112220830		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:192150512G>T	ENST00000367460.3	+	4	555	c.374G>T	c.(373-375)aGc>aTc	p.S125I		NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	125	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TTCAAGAAAAGCAAGGGACCT	0.328000													17	21					1.5739e-10	2.48899e-10	0.004007	1	0
MCF2	4168	broad.mit.edu	37	X	138684576	138684576	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:138684576C>A	ENST00000520602.1	-	19	2290	c.2005G>T	c.(2005-2007)Gca>Tca	p.A669S	MCF2_ENST00000338585.6_Missense_Mutation_p.A625S|MCF2_ENST00000370578.4_Missense_Mutation_p.A754S|MCF2_ENST00000414978.1_Missense_Mutation_p.A669S|MCF2_ENST00000536274.1_Missense_Mutation_p.A570S|MCF2_ENST00000519895.1_Missense_Mutation_p.A685S|MCF2_ENST00000370573.4_Missense_Mutation_p.A609S|MCF2_ENST00000370576.4_Missense_Mutation_p.A609S			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	609	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TGGAAAAATGCGCATTCTGAA	0.294000													21	51					2.37509e-13	4.0787e-13	0.010504	1	0
TRPC4	7223	broad.mit.edu	37	13	38225495	38225495	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:38225495G>T	ENST00000379705.3	-	8	2843	c.1986C>A	c.(1984-1986)agC>agA	p.S662R	TRPC4_ENST00000379681.3_Missense_Mutation_p.S662R|TRPC4_ENST00000338947.5_Missense_Mutation_p.S489R|TRPC4_ENST00000358477.2_Missense_Mutation_p.S662R|TRPC4_ENST00000447043.1_Missense_Mutation_p.S662R|TRPC4_ENST00000355779.2_Missense_Mutation_p.S662R|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Intron|TRPC4_ENST00000379679.1_Missense_Mutation_p.S489R			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	662	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GAGACTTGGGGCTCGGGATGA	0.423000													12	53					6.40141e-05	7.73298e-05	0.010729	1	0
NRCAM	4897	broad.mit.edu	37	7	107823173	107823173	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:107823173C>A	ENST00000379028.3	-	23	2966	c.2496G>T	c.(2494-2496)gaG>gaT	p.E832D	NRCAM_ENST00000413765.2_Missense_Mutation_p.E813D|NRCAM_ENST00000351718.4_Missense_Mutation_p.E816D|NRCAM_ENST00000379022.4_Missense_Mutation_p.E832D|NRCAM_ENST00000379024.4_Missense_Mutation_p.E813D|NRCAM_ENST00000425651.2_Missense_Mutation_p.E832D			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	832	Fibronectin type-III 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						CTACAGCTGGCTCGGGGGCAA	0.483000													20	42					1.96292e-10	3.08152e-10	0.010504	1	0
PRG3	10394	broad.mit.edu	37	11	57145281	57145281	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:57145281T>A	ENST00000287143.2	-	5	645	c.536A>T	c.(535-537)gAt>gTt	p.D179V		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	179	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						GTGGCTCCCATCAGTCCAGCA	0.562000													6	26					0	0	0.001984	0	0
PVRL2	5819	broad.mit.edu	37	19	45391414	45391414	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:45391414A>G	ENST00000252483.5	+	9	1395	c.1395A>G	c.(1393-1395)ggA>ggG	p.G465G	CTB-129P6.4_ENST00000585408.1_RNA	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	465					adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		AACGGTCAGGACCCTTGCACC	0.592000													11	40					0	0	0.008291	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948138	119948138	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:119948138A>T	ENST00000307142.4	+	3	810	c.614A>T	c.(613-615)cAg>cTg	p.Q205L	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.Q205L|SYNPO2_ENST00000434046.2_Missense_Mutation_p.Q205L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	205						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCCCTTTCACAGGAGAGACAT	0.537000													9	21					0	0	0.004482	0	0
C14orf28	122525	broad.mit.edu	37	14	45369870	45369870	+	Missense_Mutation	SNP	A	A	T	rs143625340		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:45369870A>T	ENST00000325192.3	+	2	507	c.232A>T	c.(232-234)Agg>Tgg	p.R78W	RP11-857B24.5_ENST00000555157.1_RNA|C14orf28_ENST00000557112.1_Missense_Mutation_p.R78W	NM_001017923.1	NP_001017923.1	Q4W4Y0	CN028_HUMAN	chromosome 14 open reading frame 28	78										endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(2)	11						AAACTTCCCTAGGGAACTCTC	0.343000													7	18					0	0	0.001984	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999948	46999948	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:46999948G>T	ENST00000374314.4	+	1	2023	c.1068G>T	c.(1066-1068)gcG>gcT	p.A356A	GPRIN2_ENST00000374317.1_Silent_p.A356A			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	356										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CCCTGGAAGCGCCTGCAGCCC	0.677000													12	91					3.07112e-06	4.01769e-06	0.010729	1	0
CKAP5	9793	broad.mit.edu	37	11	46783552	46783552	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:46783552T>C	ENST00000529230.1	-	32	4265	c.4219A>G	c.(4219-4221)Aat>Gat	p.N1407D	CKAP5_ENST00000415402.1_Missense_Mutation_p.N1407D|CKAP5_ENST00000354558.3_Missense_Mutation_p.N1407D|CKAP5_ENST00000312055.5_Missense_Mutation_p.N1407D			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1407					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TCACTCACATTTCCAATCAGT	0.438000													8	58					0	0	0.003080	0	0
LILRB4	11006	broad.mit.edu	37	19	55177354	55177354	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:55177354C>A	ENST00000391736.1	+	9	1161	c.846C>A	c.(844-846)caC>caA	p.H282Q	LILRB4_ENST00000430952.2_Missense_Mutation_p.H282Q|LILRB4_ENST00000391733.3_Missense_Mutation_p.H282Q|LILRB4_ENST00000391734.3_Missense_Mutation_p.H282Q|LILRB4_ENST00000270452.2_Missense_Mutation_p.H282Q	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	282						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		tcctccAACACTGGCGTCAGG	0.587000													20	18					1.00905e-13	1.74327e-13	0.008871	1	0
RP11-166D19.1	0	broad.mit.edu	37	11	121970474	121970474	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:121970474C>T	ENST00000531381.1	-	0	732				MIR125B1_ENST00000385236.1_RNA																							AAGCACGACTCGCAGCTCCCA	0.413000													11	19					0	0	0.010729	0	0
PALM	5064	broad.mit.edu	37	19	746629	746629	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:746629G>C	ENST00000264560.7	+	8	1041	c.847G>C	c.(847-849)Gag>Cag	p.E283Q	PALM_ENST00000606643.1_3'UTR|PALM_ENST00000338448.5_Missense_Mutation_p.E327Q	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	327					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		CATCACGGCGGAGCTGGTGGT	0.627000													6	14					0	0	0.001168	0	0
PLCXD3	345557	broad.mit.edu	37	5	41381964	41381964	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:41381964C>T	ENST00000377801.3	-	2	850	c.776G>A	c.(775-777)gGg>gAg	p.G259E	PLCXD3_ENST00000328457.3_Missense_Mutation_p.G259E			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	259					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						ACTTGCCACCCCTTTGACCAC	0.418000													13	122					0	0	0.001368	0	0
REM1	28954	broad.mit.edu	37	20	30064471	30064471	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:30064471G>T	ENST00000201979.2	+	2	516	c.223G>T	c.(223-225)Ggc>Tgc	p.G75C	DEFB124_ENST00000481595.1_5'UTR	NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	75					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CGACTCTGAAGGCTCCTGGGA	0.597000													22	38					6.33239e-15	1.13745e-14	0.010504	1	0
BAGE2	85319	broad.mit.edu	37	21	11049552	11049552	+	RNA	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:11049552G>C	ENST00000470054.1	-	0	556									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTGACCACAAGTAGTACAAAA	0.448000													5	66					0	0	0.001168	0	0
COL9A1	1297	broad.mit.edu	37	6	71009794	71009794	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:71009794T>A	ENST00000357250.6	-	4	409	c.251A>T	c.(250-252)cAg>cTg	p.Q84L	COL9A1_ENST00000370496.3_Missense_Mutation_p.Q84L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	84	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GTAAGCCACCTGCAATGTAGC	0.363000													11	33					0	0	0.010729	0	0
CCDC37	348807	broad.mit.edu	37	3	126135295	126135295	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:126135295C>A	ENST00000393425.1	+	5	461	c.362C>A	c.(361-363)gCc>gAc	p.A121D	CCDC37_ENST00000505024.1_Missense_Mutation_p.A121D|CCDC37_ENST00000352312.1_Missense_Mutation_p.A121D			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	121										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CGCGCCGAGGCCGAGCATCAG	0.677000													4	21					0.00024832	0.000288615	0.009096	1	0
OR6K3	391114	broad.mit.edu	37	1	158686986	158686986	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:158686986T>A	ENST00000368146.1	-	1	967	c.968A>T	c.(967-969)cAa>cTa	p.Q323L	OR6K3_ENST00000368145.1_Missense_Mutation_p.Q307L			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	323					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					CAACACTTTTTGAAGACAGAA	0.388000													16	96					0	0	0.003163	0	0
CALR3	125972	broad.mit.edu	37	19	16595992	16595992	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:16595992C>T	ENST00000269881.3	-	4	536	c.474G>A	c.(472-474)aaG>aaA	p.K158K	CTD-3222D19.2_ENST00000409035.1_Intron	NM_145046.4	NP_659483.2	Q96L12	CALR3_HUMAN	calreticulin 3	158	N-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|prostate(1)|skin(1)	15						TGATCAGTTTCTTGTTTTCGT	0.308000													6	13					0	0	0.001168	0	0
WDR72	256764	broad.mit.edu	37	15	53998260	53998260	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:53998260A>T	ENST00000396328.1	-	10	1205	c.966T>A	c.(964-966)cgT>cgA	p.R322R	WDR72_ENST00000559418.1_Silent_p.R332R|WDR72_ENST00000360509.5_Silent_p.R322R|WDR72_ENST00000557913.1_Silent_p.R319R	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	322										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TAACAAAGGGACGGCTCTGTT	0.383000													7	12					0	0	0.001984	0	0
ARAP2	116984	broad.mit.edu	37	4	36230838	36230838	+	Nonsense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:36230838T>A	ENST00000303965.4	-	2	760	c.271A>T	c.(271-273)Aag>Tag	p.K91*		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	91					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TGGTAATCCTTTGAAGGGTCA	0.363000													14	42					0	0	0.002450	0	0
TEKT5	146279	broad.mit.edu	37	16	10788224	10788224	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:10788224C>T	ENST00000283025.2	-	1	578	c.507G>A	c.(505-507)ttG>ttA	p.L169L		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	169					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TGACCGTCTCCAAGTTCTGGT	0.612000													33	154					0	0	0.003755	0	0
TTN	7273	broad.mit.edu	37	2	179501527	179501527	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179501527C>T	ENST00000589042.1	-	225	41152		c.e225-1		TTN_ENST00000342175.6_Splice_Site|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Splice_Site|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Splice_Site|TTN_ENST00000591111.1_Splice_Site|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGGTACACCTAATTCAAAG	0.433000													6	54					0	0	0.001168	0	0
FGB	2244	broad.mit.edu	37	4	155487640	155487640	+	Splice_Site	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:155487640G>A	ENST00000302068.4	+	3	369		c.e3-1		FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_Splice_Site	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TTTGTTTTTAGGGGGTGTTGT	0.388000													6	39					0	0	0.001984	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790029	6790029	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6790029G>T	ENST00000338569.2	-	1	257	c.160C>A	c.(160-162)Cgg>Agg	p.R54R		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	54			R -> P (in dbSNP:rs10839616).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGTGGAGCCGGGCTTCTATG	0.542000													20	49					7.41877e-09	1.10128e-08	0.012319	1	0
CROT	54677	broad.mit.edu	37	7	87021880	87021880	+	Splice_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:87021880A>T	ENST00000331536.3	+	15	1610		c.e15-1		CROT_ENST00000442291.1_Splice_Site|CROT_ENST00000419147.2_Splice_Site	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase						fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TTTTTAATACAGCTTCGTGAG	0.343000													20	113					0	0	0.010504	0	0
HCK	3055	broad.mit.edu	37	20	30689292	30689292	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:30689292C>A	ENST00000534862.1	+	14	1854	c.1491C>A	c.(1489-1491)gcC>gcA	p.A497A	HCK_ENST00000520553.1_Silent_p.A496A|HCK_ENST00000518730.1_Silent_p.A495A|HCK_ENST00000375852.2_Silent_p.A517A|HCK_ENST00000375862.2_Silent_p.A516A|HCK_ENST00000538448.1_Silent_p.A496A	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	517	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCTACACGGCCACAGAGAGCC	0.607000													4	18					0.00909568	0.00969341	0.009096	1	0
SPEN	23013	broad.mit.edu	37	1	16257201	16257201	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:16257201C>G	ENST00000375759.3	+	11	4670	c.4466C>G	c.(4465-4467)cCt>cGt	p.P1489R		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1489					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCTCCAAGACCTATTCCATCC	0.378000													14	29					0	0	0.001855	0	0
OR4N4	283694	broad.mit.edu	37	15	22382574	22382574	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:22382574C>G	ENST00000328795.4	+	1	193	c.102C>G	c.(100-102)ttC>ttG	p.F34L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTTAATTTTCTACCTTATCA	0.423000													27	178					0	0	0.005443	0	0
DNM1P46	196968	broad.mit.edu	37	15	100341411	100341411	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:100341411G>T	ENST00000341853.1	-	0	262					NR_003260.1																						AAGGGCATCAGGGTGGCCAGG	0.582000													8	20					2.17888e-05	2.72201e-05	0.006214	1	0
USP31	57478	broad.mit.edu	37	16	23101980	23101980	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:23101980C>T	ENST00000219689.7	-	7	1379	c.1380G>A	c.(1378-1380)gtG>gtA	p.V460V		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	460					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		CTCGGTTACACACCAACAGGA	0.438000													7	36					0	0	0.003080	0	0
RYR2	6262	broad.mit.edu	37	1	237777402	237777402	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:237777402C>A	ENST00000366574.2	+	37	5291	c.4974C>A	c.(4972-4974)ctC>ctA	p.L1658L	RYR2_ENST00000542537.1_Silent_p.L1642L|RYR2_ENST00000360064.6_Silent_p.L1656L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1658	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCACACTCTCCGGCTCTACT	0.498000													7	33					8.12818e-05	9.70302e-05	0.001984	1	0
NLRC5	84166	broad.mit.edu	37	16	57060697	57060697	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:57060697G>T	ENST00000436936.1	+	6	2067	c.1842G>T	c.(1840-1842)gaG>gaT	p.E614D	NLRC5_ENST00000539144.1_Missense_Mutation_p.E614D|NLRC5_ENST00000308149.7_Missense_Mutation_p.E614D|NLRC5_ENST00000262510.6_Missense_Mutation_p.E614D			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	614					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AGGTTGTAGAGCTGTGTCACT	0.572000													23	29					3.62473e-10	5.64394e-10	0.012319	1	0
MUC16	94025	broad.mit.edu	37	19	9084796	9084796	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9084796G>T	ENST00000397910.4	-	1	7222	c.7019C>A	c.(7018-7020)aCa>aAa	p.T2340K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2340	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTGAAACTGTGCTGGTCTC	0.473000													8	23					0.000274275	0.000316429	0.004482	1	0
PDGFRA	5156	broad.mit.edu	37	4	55151608	55151608	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:55151608C>A	ENST00000257290.5	+	17	2725	c.2394C>A	c.(2392-2394)ttC>ttA	p.F798L	FIP1L1_ENST00000507166.1_Missense_Mutation_p.F558L	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	798	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGTTGAGCTTCACCTATCAAG	0.393000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			15	26					1.15088e-07	1.61367e-07	0.004007	1	0
MAGEB4	4115	broad.mit.edu	37	X	30261205	30261205	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:30261205G>A	ENST00000378982.2	+	1	1149	c.953G>A	c.(952-954)cGg>cAg	p.R318Q		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	318										breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						GCTGGAGCCCGGCCCAGAGTT	0.532000													12	17					0	0	0.010729	0	0
NRXN1	9378	broad.mit.edu	37	2	50850623	50850623	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:50850623C>A	ENST00000404971.1	-	7	2401	c.1062G>T	c.(1060-1062)atG>atT	p.M354I	NRXN1_ENST00000406859.3_Missense_Mutation_p.M321I|NRXN1_ENST00000401669.2_Missense_Mutation_p.M321I|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.M321I|NRXN1_ENST00000405472.3_Missense_Mutation_p.M321I|NRXN1_ENST00000402717.3_Missense_Mutation_p.M321I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	321	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGTGTGAAGCATCAGTCCAT	0.433000													35	66					6.90743e-12	1.13626e-11	0.003755	1	0
GYPC	2995	broad.mit.edu	37	2	127453522	127453522	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:127453522G>T	ENST00000259254.4	+	4	522	c.190_splice	c.e4-1	p.G64_splice	GYPC_ENST00000409836.3_Splice_Site_p.G45_splice|GYPC_ENST00000464053.1_3'UTR|GYPC_ENST00000356887.7_Splice_Site_p.G43_splice	NM_002101.4	NP_002092.1	P04921	GLPC_HUMAN	glycophorin C (Gerbich blood group)	64						cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|prostate(2)|urinary_tract(1)	13	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CCACCTGCAGGTGTGATTGCT	0.587000													9	94					3.86212e-05	4.72862e-05	0.008291	1	0
ATP7B	540	broad.mit.edu	37	13	52548750	52548750	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:52548750A>G	ENST00000242839.4	-	2	762	c.606T>C	c.(604-606)aaT>aaC	p.N202N	ATP7B_ENST00000542656.1_Silent_p.N170N|ATP7B_ENST00000418097.2_Silent_p.N202N|ATP7B_ENST00000344297.5_Silent_p.N202N|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000448424.2_Silent_p.N202N|ATP7B_ENST00000400370.3_Silent_p.N202N|ATP7B_ENST00000400366.3_Silent_p.N202N	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	202	HMA 2.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATCCCATGTCATTTACATGGT	0.473000									Wilson disease				21	83					0	0	0.012319	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885086	88885086	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:88885086G>T	ENST00000319675.3	-	1	1210	c.1114C>A	c.(1114-1116)Ctc>Atc	p.L372I		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	372										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AAGCCCCCGAGGCGAGAAGAG	0.592000													9	39					2.17888e-05	2.72201e-05	0.006214	1	0
ZIC4	84107	broad.mit.edu	37	3	147120515	147120515	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:147120515T>A	ENST00000383075.3	-	2	582	c.70_splice	c.e2+1	p.S24_splice	ZIC4_ENST00000525172.2_Splice_Site_p.S74_splice|ZIC4_ENST00000425731.3_Splice_Site_p.S62_splice|ZIC4_ENST00000484399.1_Splice_Site_p.S24_splice|ZIC4_ENST00000491672.1_Splice_Site_p.S24_splice|ZIC4_ENST00000473123.1_Splice_Site_p.S24_splice	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	24	Poly-Ser.					nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TTTAACTTACTTGACTCTTTA	0.333000													16	39					0	0	0.008871	0	0
COL1A2	1278	broad.mit.edu	37	7	94043556	94043556	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:94043556C>T	ENST00000297268.6	+	29	2159	c.1688C>T	c.(1687-1689)cCc>cTc	p.P563L		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	563					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCTCAGGTCCCGCTGGTGAA	0.433000										HNSCC(75;0.22)			5	36					0	0	0.001984	0	0
PRSS38	339501	broad.mit.edu	37	1	228003799	228003799	+	Silent	SNP	C	C	A	rs138900240		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:228003799C>A	ENST00000366757.3	+	2	181	c.157C>A	c.(157-159)Cgg>Agg	p.R53R		NM_183062.2	NP_898885.1	A1L453	PRS38_HUMAN	protease, serine, 38	53					proteolysis	extracellular region	serine-type endopeptidase activity	p.?(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						AGCCTGTGGTCGGCCCAGCAT	0.701000													15	53					1.99824e-07	2.79266e-07	0.004990	1	0
DCC	1630	broad.mit.edu	37	18	50683813	50683813	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:50683813G>T	ENST00000442544.2	+	8	1965	c.1349G>T	c.(1348-1350)cGc>cTc	p.R450L	DCC_ENST00000412726.1_Missense_Mutation_p.R298L|DCC_ENST00000581580.1_Missense_Mutation_p.R105L	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	450	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTCAGCTGGCGCCCACCTGCA	0.502000													17	65					7.07596e-05	8.54184e-05	0.006122	1	0
OR5M10	390167	broad.mit.edu	37	11	56345057	56345057	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56345057C>A	ENST00000526812.2	-	1	206	c.141G>T	c.(139-141)ctG>ctT	p.L47L		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TCCTGATCAGCAGGATCATGC	0.468000													32	66					2.08457e-15	3.75616e-15	0.010818	1	0
DACH1	1602	broad.mit.edu	37	13	72255997	72255997	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:72255997G>T	ENST00000305425.4	-	2	1322	c.900C>A	c.(898-900)tcC>tcA	p.S300S	DACH1_ENST00000354591.4_Silent_p.S300S|DACH1_ENST00000359684.2_Silent_p.S300S|DACH1_ENST00000313174.7_Silent_p.S300S	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	298	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGTTCTCTGGGGAGGTGACAC	0.418000													3	34					2.89027e-11	4.66514e-11	0.002299	1	0
DLG4	1742	broad.mit.edu	37	17	7107104	7107104	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:7107104C>A	ENST00000399510.2	-	7	1223	c.371G>T	c.(370-372)gGt>gTt	p.G124V	DLG4_ENST00000399506.2_Missense_Mutation_p.G81V|DLG4_ENST00000485100.1_Missense_Mutation_p.G78V|DLG4_ENST00000302955.6_Missense_Mutation_p.G78V	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	81	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						GTCAGTGCCACCTGCGATGCT	0.612000													8	13					5.18039e-06	6.69053e-06	0.003080	1	0
OR4K5	79317	broad.mit.edu	37	14	20389373	20389373	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20389373G>T	ENST00000315915.4	+	1	633	c.608G>T	c.(607-609)aGt>aTt	p.S203I		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTCAATAGTGGAATTCTT	0.418000													57	87					2.44813e-32	4.88207e-32	0.003610	1	0
OR9Q1	219956	broad.mit.edu	37	11	57947257	57947257	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:57947257T>A	ENST00000335397.3	+	3	657	c.341T>A	c.(340-342)cTc>cAc	p.L114H		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GACTGCTACCTCTTGGCCCTC	0.557000													13	60					0	0	0.001855	0	0
IBTK	25998	broad.mit.edu	37	6	82910357	82910357	+	Silent	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:82910357T>G	ENST00000306270.7	-	20	3408	c.2859A>C	c.(2857-2859)gtA>gtC	p.V953V	IBTK_ENST00000503631.1_Silent_p.V752V|IBTK_ENST00000510291.1_Silent_p.V953V	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	953					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CTCCATCTTCTACTTCCAAAT	0.318000													5	19					0	0	0.000602	0	0
NUP210L	91181	broad.mit.edu	37	1	154108410	154108410	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:154108410G>T	ENST00000368559.3	-	7	960	c.889C>A	c.(889-891)Caa>Aaa	p.Q297K	NUP210L_ENST00000271854.3_Missense_Mutation_p.Q297K	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	297						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CTATGGTCTTGCAATTCCAGT	0.413000													9	46					3.86212e-05	4.72862e-05	0.008291	1	0
ADH1B	125	broad.mit.edu	37	4	100237443	100237443	+	Silent	SNP	C	C	A	rs146657145		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:100237443C>A	ENST00000305046.8	-	4	343	c.276G>T	c.(274-276)ccG>ccT	p.P92P	ADH1B_ENST00000394887.3_Silent_p.P52P			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	92					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GAGTAAAGAGCGGGATGACTT	0.373000													10	25					2.17888e-05	2.72201e-05	0.006214	1	0
PROK1	84432	broad.mit.edu	37	1	110996618	110996618	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:110996618C>A	ENST00000271331.3	+	2	125	c.108C>A	c.(106-108)acC>acA	p.T36T		NM_032414.2	NP_115790.1	P58294	PROK1_HUMAN	prokineticin 1	36					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGGCAGGCACCTGCTGTGCCA	0.627000													4	19					0.000602214	0.000681505	0.000602	1	0
C10orf54	64115	broad.mit.edu	37	10	73511558	73511558	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:73511558G>A	ENST00000394957.3	-	6	823	c.765C>T	c.(763-765)ccC>ccT	p.P255P	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	255						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CTTTGGCCTCGGGTATCCCCT	0.607000													14	37					0	0	0.001855	0	0
VCPIP1	80124	broad.mit.edu	37	8	67578701	67578701	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:67578701C>A	ENST00000310421.4	-	1	751	c.493G>T	c.(493-495)Gac>Tac	p.D165Y		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	165					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			AAGGCGCGGTCACCCAGTAAG	0.552000													21	74					1.9806e-07	2.77026e-07	0.002299	1	0
HGF	3082	broad.mit.edu	37	7	81386553	81386553	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:81386553C>A	ENST00000222390.5	-	4	660	c.434G>T	c.(433-435)aGt>aTt	p.S145I	HGF_ENST00000444829.2_Missense_Mutation_p.S145I|HGF_ENST00000453411.1_Missense_Mutation_p.S145I|HGF_ENST00000453018.1_Missense_Mutation_p.S42I|HGF_ENST00000457544.2_Missense_Mutation_p.S145I|HGF_ENST00000354224.6_Missense_Mutation_p.S145I|HGF_ENST00000423064.2_Missense_Mutation_p.S145I	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	145	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTTGATGCCACTCTTAGTGAT	0.378000													22	48					2.98393e-07	4.1366e-07	0.002780	1	0
MYO7B	4648	broad.mit.edu	37	2	128331623	128331623	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:128331623C>T	ENST00000389524.4	+	7	774	c.721C>T	c.(721-723)Cgg>Tgg	p.R241W	MYO7B_ENST00000409816.2_Missense_Mutation_p.R241W|MYO7B_ENST00000428314.1_Missense_Mutation_p.R241W			Q6PIF6	MYO7B_HUMAN	myosin VIIB	241	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGAGAAGTCCCGGGTCTGCCG	0.607000													25	98					0	0	0.005443	0	0
SPEG	10290	broad.mit.edu	37	2	220353835	220353835	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:220353835C>A	ENST00000312358.7	+	35	8341	c.8209C>A	c.(8209-8211)Cac>Aac	p.H2737N	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2737	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CAACGTGACCCACCTGCCAGT	0.607000													22	83					2.70639e-06	3.56497e-06	0.002299	1	0
CCDC171	203238	broad.mit.edu	37	9	15971664	15971664	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:15971664G>A	ENST00000380701.3	+	26	4139	c.3811G>A	c.(3811-3813)Gac>Aac	p.D1271N	CCDC171_ENST00000486641.2_Intron	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1271																	TCTTCCTGCTGACACAACTGG	0.368000													18	113					0	0	0.007413	0	0
ADGRG6	57211	broad.mit.edu	37	6	142741181	142741181	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:142741181G>T	ENST00000230173.6	+	22	3735	c.3259G>T	c.(3259-3261)Gcc>Tcc	p.A1087S	GPR126_ENST00000367608.2_Missense_Mutation_p.A1059S|GPR126_ENST00000367609.3_Missense_Mutation_p.A1087S|GPR126_ENST00000296932.8_Missense_Mutation_p.A1059S	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	1087					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TGCATTCTTTGCCTGGGGACC	0.433000													23	103					3.8784e-16	7.0401e-16	0.012319	1	0
FBXL7	23194	broad.mit.edu	37	5	15928016	15928016	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:15928016C>T	ENST00000504595.1	+	3	626	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C	FBXL7_ENST00000329673.7_Missense_Mutation_p.R37C|FBXL7_ENST00000510662.1_Missense_Mutation_p.R2C	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	49					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CCTGAGCATGCGCACACTGAG	0.567000													19	184					0	0	0.012319	0	0
BACH2	60468	broad.mit.edu	37	6	90660542	90660542	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:90660542C>A	ENST00000257749.4	-	7	1990	c.1283G>T	c.(1282-1284)cGg>cTg	p.R428L	RP3-512E2.2_ENST00000413986.1_RNA|RP3-512E2.2_ENST00000445838.1_RNA|BACH2_ENST00000537989.1_Missense_Mutation_p.R428L|BACH2_ENST00000343122.3_Missense_Mutation_p.R428L	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	428						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CACGCTCCTCCGGTCCAGCTC	0.602000													10	51					9.70103e-10	1.49026e-09	0.008291	1	0
ADSSL1	122622	broad.mit.edu	37	14	105206120	105206120	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:105206120A>T	ENST00000332972.5	+	5	731	c.572A>T	c.(571-573)cAg>cTg	p.Q191L	ADSSL1_ENST00000330877.2_Missense_Mutation_p.Q148L	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	148					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GACGGACTTCAGGAAGTGCAG	0.592000													20	25					0	0	0.012319	0	0
PRDM14	63978	broad.mit.edu	37	8	70981464	70981464	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:70981464G>T	ENST00000276594.2	-	2	833	c.632C>A	c.(631-633)cCc>cAc	p.P211H		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CTCCAGGCTGGGAGTGACCCC	0.592000													50	39					1.22102e-19	2.31926e-19	0.003610	1	0
MEGF10	84466	broad.mit.edu	37	5	126771134	126771134	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:126771134G>T	ENST00000274473.6	+	17	2324	c.2057G>T	c.(2056-2058)aGa>aTa	p.R686I	MEGF10_ENST00000503335.2_Missense_Mutation_p.R686I	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	686	EGF-like 12.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CCCATTGACAGATCTTGTCAG	0.423000													9	10					1.12685e-05	1.4264e-05	0.004482	1	0
MX2	4600	broad.mit.edu	37	21	42748938	42748938	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:42748938A>G	ENST00000330714.3	+	2	289	c.105A>G	c.(103-105)ccA>ccG	p.P35P	MX2_ENST00000543692.1_Silent_p.P35P	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	35					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGCCACCGCCATTCGGCACAG	0.498000													15	70					0	0	0.004007	0	0
OR8H1	219469	broad.mit.edu	37	11	56057627	56057627	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56057627C>G	ENST00000313022.2	-	1	939	c.912G>C	c.(910-912)atG>atC	p.M304I		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					GTCTTCTCTGCATGACTCTAA	0.348000													25	89					0	0	0.003954	0	0
ITGA7	3679	broad.mit.edu	37	12	56089355	56089355	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:56089355C>A	ENST00000257880.7	-	15	2305	c.2086G>T	c.(2086-2088)Gcc>Tcc	p.A696S	ITGA7_ENST00000394229.2_Missense_Mutation_p.A652S|ITGA7_ENST00000347027.6_Missense_Mutation_p.A646S|ITGA7_ENST00000257879.6_Missense_Mutation_p.A652S|ITGA7_ENST00000394230.2_Missense_Mutation_p.A656S|ITGA7_ENST00000452168.2_Missense_Mutation_p.A559S|ITGA7_ENST00000553804.1_Missense_Mutation_p.A656S|ITGA7_ENST00000555728.1_Missense_Mutation_p.A696S			Q13683	ITA7_HUMAN	integrin, alpha 7	696					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGAAGCGGGCGCGGACCAGC	0.587000													14	47					1.3612e-06	1.8252e-06	0.003163	1	0
PAPPA2	60676	broad.mit.edu	37	1	176811528	176811528	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:176811528G>T	ENST00000367662.3	+	23	6478	c.5314G>T	c.(5314-5316)Gct>Tct	p.A1772S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1772					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CATTCCATTTGCTGCTGACTG	0.502000													5	33					2.0095e-06	2.66743e-06	0.001984	1	0
SALL1	6299	broad.mit.edu	37	16	51171426	51171426	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:51171426G>T	ENST00000440970.1	-	3	3712	c.3281C>A	c.(3280-3282)gCa>gAa	p.A1094E	SALL1_ENST00000541611.1_Missense_Mutation_p.A14E|SALL1_ENST00000566102.1_3'UTR|SALL1_ENST00000251020.4_Missense_Mutation_p.A1191E	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1191					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACCCCGTCGTGCAGGGGTGCT	0.547000													5	27					3.59834e-05	4.44363e-05	0.001168	1	0
INHBA	3624	broad.mit.edu	37	7	41739856	41739856	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:41739856C>T	ENST00000242208.4	-	2	363	c.117G>A	c.(115-117)gcG>gcA	p.A39A	INHBA-AS1_ENST00000415848.2_RNA|INHBA-AS1_ENST00000422822.1_RNA|AC005027.3_ENST00000416150.1_RNA|INHBA-AS1_ENST00000420821.1_RNA|INHBA_ENST00000442711.1_Silent_p.A39A	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	39					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GGGCGGCCAGCGCACAGGACG	0.577000										TSP Lung(11;0.080)			105	129					0	0	0.003610	0	0
LPHN1	22859	broad.mit.edu	37	19	14266339	14266339	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:14266339T>A	ENST00000340736.6	-	19	3438	c.3140_splice	c.e19-1	p.K1047_splice	CTB-55O6.12_ENST00000592086.1_RNA|LPHN1_ENST00000361434.3_Splice_Site_p.K1042_splice|CTB-55O6.12_ENST00000588658.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1047					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCGCCCAGGATCTGGGAGTGG	0.677000													22	27					0	0	0.002299	0	0
PCDH15	65217	broad.mit.edu	37	10	55569178	55569178	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:55569178T>A	ENST00000395445.1	-	36	5026	c.4632A>T	c.(4630-4632)agA>agT	p.R1544S	PCDH15_ENST00000395442.1_Missense_Mutation_p.R409S|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.R740S|PCDH15_ENST00000395440.1_Missense_Mutation_p.R478S	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGGGAATATTCTGGCTCTCT	0.433000										HNSCC(58;0.16)			26	88					0	0	0.003330	0	0
TTN	7273	broad.mit.edu	37	2	179417574	179417574	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179417574G>T	ENST00000589042.1	-	335	90277	c.90053C>A	c.(90052-90054)cCc>cAc	p.P30018H	TTN_ENST00000342175.6_Missense_Mutation_p.P21145H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P20953H|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P21078H|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P28377H|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P27450H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28377	Ig-like 136.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTTCACAGGGTTCCCCAAT	0.433000													13	64					0.00010058	0.000119569	0.001368	1	0
DGKI	9162	broad.mit.edu	37	7	137080404	137080404	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:137080404G>T	ENST00000453654.1	-	32	2567	c.2028C>A	c.(2026-2028)aaC>aaA	p.N676K	DGKI_ENST00000288490.5_Missense_Mutation_p.N1007K|DGKI_ENST00000446122.1_Missense_Mutation_p.N989K|DGKI_ENST00000424189.2_Missense_Mutation_p.N1020K|DGKI_ENST00000494390.1_5'UTR			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1007					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						ACACAGCCCGGTTCCGCTGGC	0.562000													15	72					7.05477e-17	1.2915e-16	0.004990	1	0
OR52R1	119695	broad.mit.edu	37	11	4825302	4825302	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:4825302C>A	ENST00000380382.1	-	1	545	c.546G>T	c.(544-546)caG>caT	p.Q182H	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.Q103H|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAAGAACACCTGGATGAGGC	0.522000													18	33					1.33834e-09	2.03954e-09	0.007413	1	0
DPY19L4	286148	broad.mit.edu	37	8	95792642	95792642	+	Splice_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:95792642A>T	ENST00000414645.2	+	15	1730	c.1632_splice	c.e15+1	p.E544_splice		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	544						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TTATGGAAAGAGGtaaaaaaa	0.299000													5	15					0	0	0.000602	0	0
OPRM1	4988	broad.mit.edu	37	6	154414435	154414435	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:154414435G>T	ENST00000229768.5	+	4	1245	c.1195G>T	c.(1195-1197)Gct>Tct	p.A399S	OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000414028.2_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000434900.2_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000419506.2_Intron|OPRM1_ENST00000522555.1_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GTCTTGCTGGGCTCTAGAGCA	0.468000													21	120					4.54149e-19	8.5601e-19	0.002299	1	0
LRP2	4036	broad.mit.edu	37	2	170063602	170063602	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:170063602C>T	ENST00000263816.3	-	39	6913	c.6628G>A	c.(6628-6630)Ggg>Agg	p.G2210R		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2210					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGTCTCTGCCCATAGTCAGCC	0.493000													24	168					0	0	0.004656	0	0
ANK2	287	broad.mit.edu	37	4	114275488	114275488	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:114275488C>A	ENST00000357077.4	+	38	5767	c.5714C>A	c.(5713-5715)tCg>tAg	p.S1905*	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Nonsense_Mutation_p.S1872*	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1872	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCACCTGTTTCGCCTTCAGGC	0.493000													16	26					1.3612e-06	1.8252e-06	0.003163	1	0
GABRP	2568	broad.mit.edu	37	5	170222293	170222293	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:170222293G>T	ENST00000518525.1	+	6	786	c.322G>T	c.(322-324)Gat>Tat	p.D108Y	GABRP_ENST00000519598.1_Missense_Mutation_p.D108Y|GABRP_ENST00000519385.1_Missense_Mutation_p.D108Y|GABRP_ENST00000265294.4_Missense_Mutation_p.D108Y			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	108						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCACTCTGGATGCCCGCCT	0.572000													36	64					3.86903e-22	7.44777e-22	0.002836	1	0
CYSLTR2	57105	broad.mit.edu	37	13	49281037	49281037	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:49281037C>A	ENST00000282018.3	+	1	87	c.84C>A	c.(82-84)agC>agA	p.S28R		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	28					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	ATAACAACAGCAGGAACTGCA	0.378000													8	43					0.00448238	0.00490153	0.004482	1	0
L1CAM	3897	broad.mit.edu	37	X	153133866	153133866	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:153133866C>A	ENST00000370060.1	-	14	1783	c.1594G>T	c.(1594-1596)Ggt>Tgt	p.G532C	L1CAM_ENST00000543994.1_Missense_Mutation_p.G534C|L1CAM_ENST00000361981.3_Missense_Mutation_p.G527C|L1CAM_ENST00000538883.1_Missense_Mutation_p.G534C|L1CAM_ENST00000361699.4_Missense_Mutation_p.G532C|L1CAM_ENST00000370055.1_Missense_Mutation_p.G527C|L1CAM_ENST00000370057.3_Missense_Mutation_p.G532C	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	532	Ig-like C2-type 6.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCCTGGAACCTTTCTTCTCG	0.612000													37	71					3.54561e-26	7.01369e-26	0.009718	1	0
TOR1B	27348	broad.mit.edu	37	9	132569606	132569606	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:132569606G>C	ENST00000259339.2	+	3	665	c.605G>C	c.(604-606)gGa>gCa	p.G202A		NM_014506.1	NP_055321.1	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B)	202					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)	12		Ovarian(14;0.0586)				CAGGTTGACGGAGTGTCTTAC	0.473000													34	94					0	0	0.003755	0	0
SMG1	23049	broad.mit.edu	37	16	18853565	18853565	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:18853565C>A	ENST00000446231.2	-	40	6843	c.6431G>T	c.(6430-6432)gGa>gTa	p.G2144V	SMG1_ENST00000389467.3_Missense_Mutation_p.G2144V			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2144					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CCCATCTGATCCAAGAAAGAG	0.418000													10	23					0.000442599	0.00050587	0.006214	1	0
SCN11A	11280	broad.mit.edu	37	3	38888539	38888539	+	Missense_Mutation	SNP	C	C	A	rs148011334		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:38888539C>A	ENST00000302328.3	-	26	5220	c.5022G>T	c.(5020-5022)atG>atT	p.M1674I	SCN11A_ENST00000456224.3_Missense_Mutation_p.M1636I|SCN11A_ENST00000450244.1_Missense_Mutation_p.M1674I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1674					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTCACTCACCATGGGCAAGT	0.463000													9	38					2.17888e-05	2.72201e-05	0.006214	1	0
DLG4	1742	broad.mit.edu	37	17	7107105	7107105	+	Missense_Mutation	SNP	C	C	A	rs12452520		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:7107105C>A	ENST00000399510.2	-	7	1222	c.370G>T	c.(370-372)Ggt>Tgt	p.G124C	DLG4_ENST00000399506.2_Missense_Mutation_p.G81C|DLG4_ENST00000485100.1_Missense_Mutation_p.G78C|DLG4_ENST00000302955.6_Missense_Mutation_p.G78C	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	81	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TCAGTGCCACCTGCGATGCTG	0.612000													8	13					5.18039e-06	6.69053e-06	0.003080	1	0
ZNF775	285971	broad.mit.edu	37	7	150094380	150094380	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:150094380G>T	ENST00000329630.5	+	3	918	c.811G>T	c.(811-813)Ggc>Tgc	p.G271C		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		cgcggtctccggccccgaggg	0.756000													8	5					5.18039e-06	6.69053e-06	0.003080	1	0
CDC27	996	broad.mit.edu	37	17	45214564	45214564	+	Missense_Mutation	SNP	A	A	T	rs78525224		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:45214564A>T	ENST00000066544.3	-	14	1960	c.1867T>A	c.(1867-1869)Tgt>Agt	p.C623S	CDC27_ENST00000527547.1_Missense_Mutation_p.C622S|CDC27_ENST00000446365.2_Missense_Mutation_p.C562S|CDC27_ENST00000531206.1_Missense_Mutation_p.C629S	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	623					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TTTCGAAAACAAGCTAATGCT	0.378000													3	17					0	0	0.004672	0	0
OR14C36	127066	broad.mit.edu	37	1	248512964	248512964	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248512964G>T	ENST00000317861.1	+	1	888	c.888G>T	c.(886-888)aaG>aaT	p.K296N		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						AGCAAATAAAGGTGGCCATCA	0.378000													12	95					1.61879e-10	2.55294e-10	0.001368	1	0
NEO1	4756	broad.mit.edu	37	15	73528767	73528767	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:73528767G>T	ENST00000339362.5	+	9	1818	c.1371G>T	c.(1369-1371)ttG>ttT	p.L457F	NEO1_ENST00000261908.6_Missense_Mutation_p.L457F|NEO1_ENST00000560262.1_Missense_Mutation_p.L457F|NEO1_ENST00000558964.1_Missense_Mutation_p.L457F|NEO1_ENST00000560352.1_3'UTR			Q92859	NEO1_HUMAN	neogenin 1	457	Fibronectin type-III 1.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TCATCAAATTGACGTGGCGGA	0.557000													50	26					4.86159e-25	9.57283e-25	0.003610	1	0
PEX2	5828	broad.mit.edu	37	8	77895675	77895675	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:77895675C>A	ENST00000419564.2	-	4	1204	c.740G>T	c.(739-741)tGt>tTt	p.C247F	PEX2_ENST00000522527.1_Missense_Mutation_p.C247F|PEX2_ENST00000357039.4_Missense_Mutation_p.C247F|PEX2_ENST00000520103.1_Missense_Mutation_p.C247F	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	247					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						CCACTCTCCACATAGAGCGCA	0.428000													7	45					0.00198382	0.00219304	0.001984	1	0
NOX3	50508	broad.mit.edu	37	6	155750056	155750056	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:155750056G>T	ENST00000159060.2	-	9	1119	c.1017C>A	c.(1015-1017)acC>acA	p.T339T		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	339	FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CAGAGGTAAGGGTGAAGGGGT	0.582000													11	60					6.40141e-05	7.73298e-05	0.010729	1	0
VEGFC	7424	broad.mit.edu	37	4	177608561	177608561	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:177608561C>T	ENST00000280193.2	-	6	1340	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K	RP11-313E19.2_ENST00000509194.1_RNA|RP11-313E19.2_ENST00000504017.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	309	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity	p.E309*(1)		biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTGTCTAGTTCTTTGTGGGGT	0.507000													39	49					0	0	0.006230	0	0
FCRL5	83416	broad.mit.edu	37	1	157497563	157497563	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:157497563G>T	ENST00000361835.3	-	9	1961	c.1804C>A	c.(1804-1806)Cat>Aat	p.H602N	FCRL5_ENST00000368191.3_Missense_Mutation_p.H517N|FCRL5_ENST00000368190.3_Missense_Mutation_p.H602N|FCRL5_ENST00000356953.4_Missense_Mutation_p.H602N	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	602	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACATCCTCATGATAAAACCAG	0.577000													16	73					4.7546e-09	7.13813e-09	0.004007	1	0
FTSJ3	117246	broad.mit.edu	37	17	61898278	61898278	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:61898278G>A	ENST00000427159.2	-	18	2638	c.1993C>T	c.(1993-1995)Ccc>Tcc	p.P665S		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	665					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						AGGCCTTCGGGGTCCAGTATC	0.473000													27	55					0	0	0.009535	0	0
OR2L8	391190	broad.mit.edu	37	1	248112346	248112346	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248112346A>G	ENST00000357191.3	+	1	187	c.187A>G	c.(187-189)Agt>Ggt	p.S63G	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TTTCCTACTGAGTCAGCTCTC	0.428000													26	262					0	0	0.005443	0	0
C4orf32	132720	broad.mit.edu	37	4	113108033	113108033	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:113108033G>T	ENST00000309733.4	+	2	522	c.338G>T	c.(337-339)gGc>gTc	p.G113V		NM_152400.2	NP_689613.1	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	113						integral to membrane							Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		TGGTTCCTTGGCCTGCAAGCC	0.393000													20	77					8.00594e-06	1.02321e-05	0.007413	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765999	171765999	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:171765999C>A	ENST00000311601.5	-	13	2280	c.2110G>T	c.(2110-2112)Gag>Tag	p.E704*	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	704					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCAGGCCCCTCTCCTGGGAGG	0.642000													8	20					1.06961e-07	1.51455e-07	0.003080	1	0
EDIL3	10085	broad.mit.edu	37	5	83549934	83549934	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:83549934G>T	ENST00000296591.5	-	2	582	c.164C>A	c.(163-165)aCa>aAa	p.T55K	EDIL3_ENST00000380138.3_Missense_Mutation_p.T55K	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	55	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GTTGGGGTCTGTGAAGCCATC	0.403000													3	20					0.00024832	0.000288615	0.009096	1	0
CSMD1	64478	broad.mit.edu	37	8	2857553	2857553	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:2857553G>C	ENST00000602557.1	-	54	8688	c.8133C>G	c.(8131-8133)ttC>ttG	p.F2711L	CSMD1_ENST00000602723.1_Missense_Mutation_p.F2653L|CSMD1_ENST00000400186.3_Missense_Mutation_p.F2653L|CSMD1_ENST00000542608.1_Missense_Mutation_p.F2652L|CSMD1_ENST00000537824.1_Missense_Mutation_p.F2710L|CSMD1_ENST00000520002.1_Missense_Mutation_p.F2711L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2711	Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCACAAGCCGGAAACCAGGAT	0.532000													19	72					0	0	0.012319	0	0
ASB5	140458	broad.mit.edu	37	4	177143474	177143474	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:177143474G>T	ENST00000296525.3	-	3	487	c.374C>A	c.(373-375)gCa>gAa	p.A125E	ASB5_ENST00000511879.1_5'UTR|ASB5_ENST00000512254.1_Missense_Mutation_p.A72E	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	125					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATTAGCTCCTGCTTCCAGCAG	0.418000													20	36					5.35267e-07	7.29678e-07	0.007413	1	0
PRAMEF1	65121	broad.mit.edu	37	1	12853545	12853545	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:12853545C>A	ENST00000332296.7	+	2	272	c.169C>A	c.(169-171)Cag>Aag	p.Q57K		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	57										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGATGGTTCAGGCCTGGCC	0.547000													20	165					1.00905e-13	1.74327e-13	0.008871	1	0
FAT3	120114	broad.mit.edu	37	11	92538504	92538504	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:92538504G>C	ENST00000298047.6	+	10	9099	c.9082G>C	c.(9082-9084)Gtg>Ctg	p.V3028L	FAT3_ENST00000409404.2_Missense_Mutation_p.V3028L|FAT3_ENST00000525166.1_Missense_Mutation_p.V2878L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3028	Cadherin 27.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAATAGCCCAGTGTGTGATCA	0.428000										TCGA Ovarian(4;0.039)			8	17					0	0	0.003080	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249829	61249829	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:61249829C>A	ENST00000338608.2	+	3	281	c.156C>A	c.(154-156)ggC>ggA	p.G52G	RP11-286N22.8_ENST00000543044.1_3'UTR|RP11-286N22.8_ENST00000544880.1_Intron|PPP1R32_ENST00000432063.2_Silent_p.G52G	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	52																	TAGGCACCGGCTACAAATCAA	0.607000											OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	37					0.000978159	0.00110043	0.010729	1	0
RAP1GAP	5909	broad.mit.edu	37	1	21928224	21928224	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:21928224C>T	ENST00000542643.2	-	22	1985	c.1683G>A	c.(1681-1683)gaG>gaA	p.E561E	RAP1GAP_ENST00000374761.2_Silent_p.E566E|RAP1GAP_ENST00000374765.4_Silent_p.E535E|RAP1GAP_ENST00000290101.4_Silent_p.E599E|RAP1GAP_ENST00000374763.2_Silent_p.E620E	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	535					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TGGATGAGTTCTCCGACTTGG	0.662000													4	32					0	0	0.009096	0	0
LINC00842	643650	broad.mit.edu	37	10	47133600	47133600	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:47133600C>A	ENST00000422732.2	-	0	435					NR_033957.1																						accaccaccacgactgccacc	0.483000													11	59					9.70103e-10	1.49026e-09	0.008291	1	0
MAEL	84944	broad.mit.edu	37	1	166990948	166990948	+	Silent	SNP	C	C	T	rs146423777		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:166990948C>T	ENST00000367872.4	+	12	1405	c.1161C>T	c.(1159-1161)agC>agT	p.S387S	MAEL_ENST00000367870.2_Silent_p.S356S|MAEL_ENST00000491055.1_3'UTR	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	387					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						AAAACAGCAGCGTTCGGGGAA	0.378000													23	20					0	0	0.003330	0	0
MYBPC1	4604	broad.mit.edu	37	12	102038463	102038463	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:102038463C>A	ENST00000549145.1	+	11	918	c.818C>A	c.(817-819)cCt>cAt	p.P273H	MYBPC1_ENST00000361466.2_Missense_Mutation_p.P285H|MYBPC1_ENST00000361685.2_Missense_Mutation_p.P285H|MYBPC1_ENST00000360610.2_Missense_Mutation_p.P260H|MYBPC1_ENST00000392934.3_Missense_Mutation_p.P247H|MYBPC1_ENST00000452455.2_Missense_Mutation_p.P260H|MYBPC1_ENST00000441232.1_Missense_Mutation_p.P260H|MYBPC1_ENST00000536007.1_Missense_Mutation_p.P241H|MYBPC1_ENST00000541119.1_Missense_Mutation_p.P248H|MYBPC1_ENST00000547405.1_Missense_Mutation_p.P234H|MYBPC1_ENST00000545503.2_Missense_Mutation_p.P260H|MYBPC1_ENST00000547509.1_Missense_Mutation_p.P246H|MYBPC1_ENST00000553190.1_Missense_Mutation_p.P260H|MYBPC1_ENST00000551300.1_Missense_Mutation_p.P161H|MYBPC1_ENST00000550270.1_Missense_Mutation_p.P260H|MYBPC1_ENST00000550501.1_Intron			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	260	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						ATTCTTGATCCTGCATATCAG	0.348000													4	18					0.00024832	0.000288615	0.009096	1	0
RPN2	6185	broad.mit.edu	37	20	35812692	35812692	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:35812692G>T	ENST00000237530.6	+	2	434	c.123G>T	c.(121-123)ctG>ctT	p.L41L	RPN2_ENST00000373622.5_Silent_p.L41L	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	41					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				AAGCCTCGCTGGATCGCCCTT	0.537000													21	49					1.55795e-14	2.75809e-14	0.012319	1	0
FAM105A	54491	broad.mit.edu	37	5	14610259	14610259	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:14610259T>C	ENST00000274217.3	+	8	1027	c.907T>C	c.(907-909)Ttt>Ctt	p.F303L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	303										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					GATTGATATGTTTATACTTGG	0.448000													21	112					0	0	0.002780	0	0
OR5R1	219479	broad.mit.edu	37	11	56185245	56185245	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56185245A>C	ENST00000312253.1	-	1	463	c.464T>G	c.(463-465)gTt>gGt	p.V155G		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					GAAGAGGGCAACCAGGAAGCT	0.453000													11	107					0	0	0.010729	0	0
FBXW7	55294	broad.mit.edu	37	4	153268138	153268138	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:153268138G>A	ENST00000281708.4	-	4	1899	c.670C>T	c.(670-672)Cga>Tga	p.R224*	FBXW7_ENST00000603841.1_Nonsense_Mutation_p.R224*|FBXW7_ENST00000263981.5_Nonsense_Mutation_p.R144*|FBXW7_ENST00000296555.5_Nonsense_Mutation_p.R106*|FBXW7_ENST00000603548.1_Nonsense_Mutation_p.R224*|FBXW7_ENST00000393956.3_Nonsense_Mutation_p.R48*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	224					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R224*(5)|p.R106*(1)|p.R144*(1)|p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GATGTAATTCGGCGTCGTTGT	0.448000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								17	64					0	0	0.006122	0	0
SLC6A17	388662	broad.mit.edu	37	1	110740984	110740984	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:110740984C>T	ENST00000331565.4	+	12	2587	c.2102C>T	c.(2101-2103)tCa>tTa	p.S701L		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	701					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GGCAGCACATCACCCCTGGAG	0.642000													8	39					0	0	0.003080	0	0
MYH13	8735	broad.mit.edu	37	17	10250078	10250078	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:10250078A>T	ENST00000418404.3	-	12	1345	c.1182T>A	c.(1180-1182)tcT>tcA	p.S394S	MYH13_ENST00000570743.1_Silent_p.S394S|MYH13_ENST00000252172.4_Silent_p.S394S			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	394	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCATTTCTGCAGAATTCAGTC	0.468000													11	14					0	0	0.008291	0	0
ADCY2	108	broad.mit.edu	37	5	7789875	7789875	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:7789875G>A	ENST00000338316.4	+	20	2679	c.2590G>A	c.(2590-2592)Gtg>Atg	p.V864M	ADCY2_ENST00000537121.1_Missense_Mutation_p.V684M	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	864					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TCCCGCGCACGTGGCTGAGCA	0.587000													20	99					0	0	0.007413	0	0
LRP1B	53353	broad.mit.edu	37	2	141108558	141108558	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:141108558A>T	ENST00000389484.3	-	77	12671	c.11700T>A	c.(11698-11700)ggT>ggA	p.G3900G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3900					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATATATAAAACCCAGGATAT	0.294000										TSP Lung(27;0.18)			7	52					0	0	0.003080	0	0
BAAT	570	broad.mit.edu	37	9	104133520	104133520	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:104133520C>A	ENST00000259407.2	-	2	275	c.167G>T	c.(166-168)gGt>gTt	p.G56V	BAAT_ENST00000395051.3_Missense_Mutation_p.G56V	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	56					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GTCCACCTCACCGAATTCATT	0.463000													13	37					2.68362e-12	4.47878e-12	0.001368	1	0
ZNF560	147741	broad.mit.edu	37	19	9584916	9584916	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9584916C>T	ENST00000301480.4	-	4	329	c.116G>A	c.(115-117)aGa>aAa	p.R39K		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	39	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CATCACATCTCTGTATAAGTT	0.438000													8	50					0	0	0.003080	0	0
IHH	3549	broad.mit.edu	37	2	219920022	219920022	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:219920022C>A	ENST00000295731.5	-	3	1142	c.1143G>T	c.(1141-1143)gtG>gtT	p.V381V		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	381					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTACCAATGCACACCCTCCC	0.652000													8	11					1.12685e-05	1.4264e-05	0.004482	1	0
SERPINA4	5267	broad.mit.edu	37	14	95030053	95030053	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:95030053C>A	ENST00000557004.1	+	2	655	c.234C>A	c.(232-234)tcC>tcA	p.S78S	SERPINA4_ENST00000298841.5_Silent_p.S78S|SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Silent_p.S78S			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	78					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		TCTTTTTCTCCCCGCTGAGCA	0.617000													12	51					4.36969e-10	6.76712e-10	0.001855	1	0
SYT10	341359	broad.mit.edu	37	12	33559883	33559883	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:33559883A>G	ENST00000228567.3	-	3	1214	c.918T>C	c.(916-918)taT>taC	p.Y306Y	SYT10_ENST00000535526.1_Silent_p.Y125Y	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	306	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTAGTTGATCATATGCTACAG	0.343000													7	20					0	0	0.004482	0	0
NAV3	89795	broad.mit.edu	37	12	78522620	78522620	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:78522620C>A	ENST00000397909.2	+	18	4588	c.4415C>A	c.(4414-4416)gCt>gAt	p.A1472D	NAV3_ENST00000228327.6_Missense_Mutation_p.A1472D|NAV3_ENST00000266692.7_Missense_Mutation_p.A1295D|NAV3_ENST00000536525.2_Missense_Mutation_p.A1472D			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1472	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCTTCTGCAGCTGGAAAATAC	0.443000										HNSCC(70;0.22)			17	33					3.52763e-06	4.59742e-06	0.004990	1	0
NKIRAS2	28511	broad.mit.edu	37	17	40174455	40174455	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:40174455G>T	ENST00000307641.5	+	3	754	c.133G>T	c.(133-135)Ggc>Tgc	p.G45C	NKIRAS2_ENST00000393880.1_Missense_Mutation_p.G45C|NKIRAS2_ENST00000393881.3_Missense_Mutation_p.G45C|NKIRAS2_ENST00000393884.2_Missense_Mutation_p.G43C|NKIRAS2_ENST00000393885.4_Missense_Mutation_p.G45C|NKIRAS2_ENST00000479407.1_Missense_Mutation_p.G45C|NKIRAS2_ENST00000462043.2_Intron|NKIRAS2_ENST00000449471.4_Missense_Mutation_p.G45C|NKIRAS2_ENST00000316082.4_Missense_Mutation_p.G45C	NM_001001349.2	NP_001001349.1	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2	45	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	9		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CATCTACGTGGGCTCCATTGA	0.552000													14	39					2.31682e-05	2.89014e-05	0.003163	1	0
NDUFS2	4720	broad.mit.edu	37	1	161179353	161179353	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:161179353C>T	ENST00000392179.4	+	5	834	c.595C>T	c.(595-597)Cct>Tct	p.P199S	NDUFS2_ENST00000367993.3_Missense_Mutation_p.P199S|NDUFS2_ENST00000476409.2_Missense_Mutation_p.P101S	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	199					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	GGCCATGACCCCTTTCTTCTG	0.483000											OREG0013941	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	10					0	0	0.008871	0	0
MOG	4340	broad.mit.edu	37	6	29638542	29638542	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:29638542G>A	ENST00000376894.4	+	7	892	c.774G>A	c.(772-774)caG>caA	p.Q258Q	MOG_ENST00000483013.1_Intron|MOG_ENST00000376891.4_Intron|MOG_ENST00000376917.3_Intron|MOG_ENST00000376898.3_Intron|MOG_ENST00000431798.2_Intron|MOG_ENST00000416766.2_Intron|MOG_ENST00000490427.1_Intron|MOG_ENST00000533330.2_Intron|MOG_ENST00000376902.3_Intron|MOG_ENST00000494692.1_Intron|MOG_ENST00000396704.3_Intron|MOG_ENST00000376888.2_Intron|MOG_ENST00000396701.2_Intron			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	0					cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						TAAAAAGCCAGGAAAGGGAGA	0.458000													11	15					0	0	0.008291	0	0
LAMP5	24141	broad.mit.edu	37	20	9498814	9498814	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:9498814G>A	ENST00000246070.2	+	5	1095	c.603G>A	c.(601-603)atG>atA	p.M201I	LAMP5_ENST00000427562.2_Missense_Mutation_p.M157I	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	201						integral to membrane		p.M201fs*33(1)									CGGTCACCATGATCCTGTCTG	0.498000													8	32					0	0	0.003080	0	0
DIAPH3	81624	broad.mit.edu	37	13	60566710	60566710	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:60566710C>A	ENST00000400324.4	-	10	1242	c.1022G>T	c.(1021-1023)tGt>tTt	p.C341F	DIAPH3_ENST00000267215.4_Missense_Mutation_p.C341F|DIAPH3_ENST00000400319.1_Missense_Mutation_p.C271F|DIAPH3_ENST00000400320.1_Missense_Mutation_p.C295F|DIAPH3_ENST00000400330.1_Missense_Mutation_p.C341F|DIAPH3_ENST00000377908.2_Missense_Mutation_p.C330F|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	341	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GAGCTGCATACAAGCTACCTA	0.378000													3	12					0.004672	0.0050606	0.004672	1	0
SERPINA11	256394	broad.mit.edu	37	14	94914504	94914504	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:94914504G>T	ENST00000334708.3	-	2	672	c.608C>A	c.(607-609)aCg>aAg	p.T203K	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	203					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity	p.T385R(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		AACCATGAACGTGTCCTGGCT	0.468000													28	45					2.48779e-11	4.03445e-11	0.005443	1	0
WDR75	84128	broad.mit.edu	37	2	190334125	190334125	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:190334125G>A	ENST00000314761.4	+	16	1839	c.1779G>A	c.(1777-1779)gaG>gaA	p.E593E		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	593						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			CTAATTCAGAGAATATTGCTG	0.368000													10	27					0	0	0.006214	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455189	84455189	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:84455189C>A	ENST00000377084.2	-	1	1339	c.454G>T	c.(454-456)Gac>Tac	p.D152Y		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	152						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTGTTCAAGTCCTGGAAGGCC	0.488000													14	49					4.3838e-07	5.98551e-07	0.001855	1	0
LTV1	84946	broad.mit.edu	37	6	144179062	144179062	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:144179062G>A	ENST00000367576.5	+	6	847	c.713G>A	c.(712-714)aGt>aAt	p.S238N		NM_032860.3	NP_116249.2	Q96GA3	LTV1_HUMAN	LTV1 homolog (S. cerevisiae)	238										breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)		GAAACAAAGAGTCGCTTCACG	0.468000													4	29					0	0	0.009096	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72489072	72489072	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:72489072A>T	ENST00000373208.1	+	5	893	c.893A>T	c.(892-894)gAg>gTg	p.E298V	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.E298V	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	298	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						TACCACGATGAGTCCCTGGGG	0.483000													9	62					0	0	0.008291	0	0
LEFTY1	10637	broad.mit.edu	37	1	226075184	226075184	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:226075184G>C	ENST00000272134.5	-	3	731	c.652C>G	c.(652-654)Ctg>Gtg	p.L218V	RP4-559A3.7_ENST00000432920.2_Missense_Mutation_p.A326G	NM_020997.3	NP_066277.1	O75610	LFTY1_HUMAN	left-right determination factor 1	218					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					AAGCGGACCAGCTTGTGGGCG	0.701000													4	43					0	0	0.000602	0	0
LPPR4	9890	broad.mit.edu	37	1	99771526	99771526	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:99771526C>A	ENST00000370185.3	+	7	1749	c.1252C>A	c.(1252-1254)Ccg>Acg	p.P418T	LPPR4_ENST00000457765.1_Missense_Mutation_p.P360T|LPPR4_ENST00000370184.1_Missense_Mutation_p.P260T	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		418							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CAATACCTTGCCGCGAGCCAA	0.498000													15	29					6.72482e-11	1.07037e-10	0.003163	1	0
KCNAB2	8514	broad.mit.edu	37	1	6142306	6142306	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:6142306G>C	ENST00000164247.1	+	6	817	c.253G>C	c.(253-255)Gat>Cat	p.D85H	KCNAB2_ENST00000378092.1_Missense_Mutation_p.D71H|KCNAB2_ENST00000378111.1_Missense_Mutation_p.D85H|KCNAB2_ENST00000378097.1_Missense_Mutation_p.D85H|KCNAB2_ENST00000458166.2_Missense_Mutation_p.D18H|KCNAB2_ENST00000378087.3_Missense_Mutation_p.D85H|KCNAB2_ENST00000378083.3_Missense_Mutation_p.D118H|KCNAB2_ENST00000602612.1_Missense_Mutation_p.D85H|KCNAB2_ENST00000352527.1_Missense_Mutation_p.D71H|KCNAB2_ENST00000341524.1_Missense_Mutation_p.D85H	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	85						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity	p.D85N(1)		large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		CAACCTCTTCGATACAGCAGA	0.557000													24	75					0	0	0.005443	0	0
ACKR3	57007	broad.mit.edu	37	2	237489920	237489920	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:237489920C>T	ENST00000272928.3	+	2	1122	c.812C>T	c.(811-813)gCg>gTg	p.A271V		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		TACCACGTGGCGGTGCTGCTG	0.607000													16	77					0	0	0.003163	0	0
C6orf106	64771	broad.mit.edu	37	6	34614553	34614553	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:34614553C>A	ENST00000374023.3	-	3	579	c.336G>T	c.(334-336)ggG>ggT	p.G112G	C6orf106_ENST00000374026.3_Intron|C6orf106_ENST00000374021.1_Silent_p.G38G	NM_024294.2	NP_077270.1	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106	112										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10						TAAGACAAACCCCTGGAGGCC	0.468000													17	111					3.52763e-06	4.59742e-06	0.004990	1	0
FZR1	51343	broad.mit.edu	37	19	3532599	3532599	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:3532599C>T	ENST00000441788.2	+	11	1429	c.1193C>T	c.(1192-1194)aCg>aTg	p.T398M	FZR1_ENST00000395095.3_Missense_Mutation_p.T398M|FZR1_ENST00000313639.8_Missense_Mutation_p.T309M	NM_016263.3	NP_057347.2	Q9UM11	FZR_HUMAN	fizzy/cell division cycle 20 related 1 (Drosophila)	398					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			endometrium(1)|kidney(4)|liver(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTATCGACACGGGCTCCCAA	0.662000													5	13					0	0	0.001168	0	0
PLXNA4	91584	broad.mit.edu	37	7	131878928	131878928	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:131878928C>G	ENST00000359827.3	-	14	3711	c.2749G>C	c.(2749-2751)Gag>Cag	p.E917Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E917Q			Q9HCM2	PLXA4_HUMAN	plexin A4	917	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCCCCCATCTCACACACGATC	0.592000													39	60					0	0	0.004878	0	0
PPY	5539	broad.mit.edu	37	17	42018976	42018976	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:42018976C>T	ENST00000591228.1	-	2	134	c.47G>A	c.(46-48)tGc>tAc	p.C16Y	PPY_ENST00000225992.3_Missense_Mutation_p.C16Y|PPY_ENST00000587006.1_Missense_Mutation_p.C16Y			P01298	PAHO_HUMAN	pancreatic polypeptide	16					digestion|protein secretion	extracellular region	hormone activity			large_intestine(2)|lung(1)|skin(1)	4		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CAGAGCCACGCAGGTGGACAG	0.642000													9	39					0	0	0.004482	0	0
ACSS2	55902	broad.mit.edu	37	20	33509666	33509666	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:33509666T>C	ENST00000360596.2	+	13	1756	c.1545T>C	c.(1543-1545)taT>taC	p.Y515Y	ACSS2_ENST00000336325.4_Silent_p.Y465Y|ACSS2_ENST00000253382.5_Silent_p.Y528Y|ACSS2_ENST00000476922.1_Intron	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	515					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTGAAGGTTATCTGGTGAGGC	0.493000													35	194					0	0	0.003271	0	0
OLFML2B	25903	broad.mit.edu	37	1	161976233	161976233	+	Missense_Mutation	SNP	C	C	T	rs138803828		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:161976233C>T	ENST00000294794.3	-	4	1000	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	OLFML2B_ENST00000367940.2_Missense_Mutation_p.E193K	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	193										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TTGATTTGTTCATTTTCCTTG	0.418000													16	59					0	0	0.003163	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29698967	29698967	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:29698967C>A	ENST00000304863.4	-	2	735	c.313G>T	c.(313-315)Gaa>Taa	p.E105*		NM_006003.2	NP_005994.2	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	105					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			TCGCTGCTTTCTCTTGAAGAC	0.473000													29	50					2.12542e-12	3.57494e-12	0.006320	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798783	55798783	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55798783G>T	ENST00000313555.1	+	1	889	c.889G>T	c.(889-891)Gtg>Ttg	p.V297L		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					AAACAAGGATGTGAAAAATGC	0.313000													15	46					6.53275e-17	1.19721e-16	0.002450	1	0
IGHV3-43	28426	broad.mit.edu	37	14	106926442	106926442	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:106926442C>T	ENST00000434710.1	-	0	179																											AGGGACCCCCCAGGCTGTACC	0.577000													24	74					0	0	0.004656	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102516461	102516461	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:102516461G>C	ENST00000360184.4	+	77	13902	c.13738G>C	c.(13738-13740)Gcc>Ccc	p.A4580P	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4580					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						ACTGTCCAATGCCATCTCAAC	0.562000													17	33					0	0	0.007413	0	0
ITGB3	3690	broad.mit.edu	37	17	45361879	45361879	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:45361879G>C	ENST00000559488.1	+	4	448	c.432G>C	c.(430-432)atG>atC	p.M144I	ITGB3_ENST00000571680.1_Missense_Mutation_p.M144I|ITGB3_ENST00000560629.1_Missense_Mutation_p.G133R|ITGB3_ENST00000435993.2_Missense_Mutation_p.M97I	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	144	VWFA.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	ACTACTTGATGGACCTGTCTT	0.488000													17	63					0	0	0.004007	0	0
ZNF703	80139	broad.mit.edu	37	8	37556059	37556059	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:37556059C>G	ENST00000331569.4	+	2	1869	c.1640C>G	c.(1639-1641)cCc>cGc	p.P547R		NM_025069.1	NP_079345.1	Q9H7S9	ZN703_HUMAN	zinc finger protein 703	547					adherens junction assembly|mammary gland epithelial cell differentiation|negative regulation of homotypic cell-cell adhesion|negative regulation of transcription, DNA-dependent|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of mammary gland epithelial cell proliferation|regulation of canonical Wnt receptor signaling pathway|regulation of cell cycle|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding		FGFR1/ZNF703(2)	breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)	7			BRCA - Breast invasive adenocarcinoma(5;7.93e-25)|LUSC - Lung squamous cell carcinoma(8;1.05e-09)			CGGTACCACCCCTATGGCAAG	0.677000													3	9					0	0	0.004672	0	0
ZNF430	80264	broad.mit.edu	37	19	21240398	21240398	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:21240398C>G	ENST00000261560.5	+	5	1465	c.1284C>G	c.(1282-1284)ccC>ccG	p.P428P		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						GAGAGAAACCCTACAAATGTG	0.363000													7	19					0	0	0.003080	0	0
SATL1	340562	broad.mit.edu	37	X	84349161	84349161	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:84349161C>A	ENST00000509231.1	-	4	1928	c.1849G>T	c.(1849-1851)Gac>Tac	p.D617Y	SATL1_ENST00000332921.5_Missense_Mutation_p.D430Y|SATL1_ENST00000395409.3_Missense_Mutation_p.D430Y			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	430							N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						ACATAAAAGTCCTCTAGGTAA	0.353000													5	31					5.9392e-07	8.07712e-07	0.001168	1	0
CELA1	1990	broad.mit.edu	37	12	51723585	51723585	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:51723585C>G	ENST00000293636.1	-	7	682	c.642G>C	c.(640-642)gtG>gtC	p.V214V		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	214	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						ACTTGCCATTCACCAAGCAAT	0.557000													26	58					0	0	0.005443	0	0
LINGO4	339398	broad.mit.edu	37	1	151774717	151774717	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:151774717A>G	ENST00000368820.3	-	2	1401	c.464T>C	c.(463-465)cTa>cCa	p.L155P		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	155						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GAGGCTGCCTAGCTCCCCAAA	0.597000													20	97					0	0	0.008871	0	0
GPRC6A	222545	broad.mit.edu	37	6	117113850	117113850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:117113850C>A	ENST00000310357.3	-	6	2257	c.2236G>T	c.(2236-2238)Gag>Tag	p.E746*	GPRC6A_ENST00000530250.1_Nonsense_Mutation_p.E571*|GPRC6A_ENST00000368549.3_Nonsense_Mutation_p.E675*	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	746					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATGGATCCCTCCTCACACTCC	0.468000													9	11					1.76689e-08	2.57834e-08	0.006214	1	0
ULK1	8408	broad.mit.edu	37	12	132403802	132403802	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:132403802T>G	ENST00000321867.4	+	24	2908	c.2557T>G	c.(2557-2559)Ttc>Gtc	p.F853V	ULK1_ENST00000540647.1_Missense_Mutation_p.F98V	NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	853					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CACGCTGCTGTTCGTGCAGCA	0.682000													9	16					0	0	0.008291	0	0
KCNE1	3753	broad.mit.edu	37	21	35821760	35821760	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:35821760G>A	ENST00000337385.3	-	3	548	c.173C>T	c.(172-174)aCc>aTc	p.T58I	KCNE1_ENST00000416357.2_Missense_Mutation_p.T58I|KCNE1_ENST00000399286.2_Missense_Mutation_p.T58I|KCNE1_ENST00000399284.1_Missense_Mutation_p.T58I|KCNE1_ENST00000432085.1_Missense_Mutation_p.T58I|KCNE1_ENST00000399289.3_Missense_Mutation_p.T58I	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	58			TL -> PP (in JLNS2).		blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	GATGCCCAGGGTGAAGAAGCC	0.602000													13	35					0	0	0.001368	0	0
SLC20A2	6575	broad.mit.edu	37	8	42294897	42294897	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:42294897C>A	ENST00000342228.3	-	8	1502	c.1133G>T	c.(1132-1134)cGg>cTg	p.R378L	SLC20A2_ENST00000520262.1_Missense_Mutation_p.R378L|SLC20A2_ENST00000520179.1_Missense_Mutation_p.R378L	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	378					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCGCAGCAGCCGGTAGTTGCT	0.597000													30	78					8.4185e-14	1.46769e-13	0.012213	1	0
ENOPH1	58478	broad.mit.edu	37	4	83378077	83378077	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:83378077G>T	ENST00000273920.3	+	5	800	c.532G>T	c.(532-534)Ggt>Tgt	p.G178C	ENOPH1_ENST00000509635.1_Missense_Mutation_p.G90C	NM_021204.3	NP_067027.1	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	178					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|skin(1)	13						GCTTGTTGATGGTCACTTTGA	0.408000													5	25					0.000602214	0.000681505	0.000602	1	0
FLT1	2321	broad.mit.edu	37	13	29004227	29004227	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:29004227A>G	ENST00000282397.4	-	8	1317	c.1066T>C	c.(1066-1068)Tct>Cct	p.S356P	FLT1_ENST00000539099.1_Missense_Mutation_p.S356P|FLT1_ENST00000541932.1_Missense_Mutation_p.S356P	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	356	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ACTTTCATAGAGAGCCGGTAA	0.433000													13	46					0	0	0.002450	0	0
CCDC14	64770	broad.mit.edu	37	3	123665764	123665764	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:123665764C>A	ENST00000485727.1	-	4	5223	c.631G>T	c.(631-633)Gat>Tat	p.D211Y	CCDC14_ENST00000483247.1_Intron|CCDC14_ENST00000488653.2_Missense_Mutation_p.D411Y|CCDC14_ENST00000489746.1_Missense_Mutation_p.D211Y|CCDC14_ENST00000433542.2_Missense_Mutation_p.D370Y|CCDC14_ENST00000310351.4_Missense_Mutation_p.D251Y			Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	411						centrosome				NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)	21		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GTTTTTGTATCTCGCACATGT	0.383000													31	80					8.88839e-20	1.69017e-19	0.010818	1	0
LHX6	26468	broad.mit.edu	37	9	124976256	124976256	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:124976256G>T	ENST00000559895.1	-	4	1106	c.228C>A	c.(226-228)atC>atA	p.I76I	LHX6_ENST00000340587.3_Silent_p.I292I|LHX6_ENST00000373754.2_Silent_p.I263I|LHX6_ENST00000373755.2_Silent_p.I263I|LHX6_ENST00000541397.2_Silent_p.I281I|LHX6_ENST00000394319.4_Silent_p.I292I	NM_001242335.1	NP_001229264.1	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	263	LIM zinc-binding 1.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						GTCCCACCTGGATGACTCTCC	0.716000													4	13					0.00024832	0.000288615	0.009096	1	0
SLC38A6	145389	broad.mit.edu	37	14	61518616	61518616	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:61518616G>T	ENST00000354886.2	+	14	1326	c.1162G>T	c.(1162-1164)Gtt>Ttt	p.V388F	SLC38A6_ENST00000267488.4_Missense_Mutation_p.V388F|SLC38A6_ENST00000456840.2_Missense_Mutation_p.V365F	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	388					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TGCAATATATGTTCCTGACAT	0.318000													4	25					0.00024832	0.000288615	0.009096	1	0
KNSTRN	90417	broad.mit.edu	37	15	40675063	40675063	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:40675063G>T	ENST00000416151.2	+	1	142	c.27G>T	c.(25-27)ctG>ctT	p.L9L	KNSTRN_ENST00000448395.2_Silent_p.L9L|KNSTRN_ENST00000249776.8_Silent_p.L9L	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		CCCCGCCCCTGGACAGAGTTT	0.592000													6	7					8.12818e-05	9.70302e-05	0.001984	1	0
HOXA1	3198	broad.mit.edu	37	7	27135176	27135176	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:27135176A>T	ENST00000343060.4	-	1	417	c.356T>A	c.(355-357)gTa>gAa	p.V119E	HOXA1_ENST00000355633.5_Splice_Site	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	119						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CCCACCACTTACGTCTGCTTC	0.567000													36	24					0	0	0.004289	0	0
SCN3A	6328	broad.mit.edu	37	2	166026976	166026976	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:166026976G>A	ENST00000360093.3	-	4	838	c.347C>T	c.(346-348)cCt>cTt	p.P116L	SCN3A_ENST00000283254.7_Missense_Mutation_p.P116L|SCN3A_ENST00000409101.3_Missense_Mutation_p.P116L	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	116						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTTCCTAACAGGGTTTAGTGG	0.313000													6	43					0	0	0.001168	0	0
MYH8	4626	broad.mit.edu	37	17	10309664	10309664	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:10309664C>G	ENST00000403437.2	-	20	2316	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	741	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AGCCTTCTTGCTGTCAATGAA	0.353000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				12	10					0	0	0.001855	0	0
BMS1	9790	broad.mit.edu	37	10	43316061	43316061	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:43316061A>T	ENST00000374518.4	+	17	2938	c.2875A>T	c.(2875-2877)Atc>Ttc	p.I959F		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	959					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ACTGTATTATATCGAAGACCA	0.423000													12	40					0	0	0.001368	0	0
CSMD1	64478	broad.mit.edu	37	8	2875998	2875998	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:2875998C>A	ENST00000602557.1	-	53	8588		c.e53+1		CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000537824.1_Splice_Site|CSMD1_ENST00000520002.1_Splice_Site			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GATGAATTTACCCAGACATCG	0.438000													30	97					1.39806e-14	2.48784e-14	0.008361	1	0
ZNF813	126017	broad.mit.edu	37	19	53994294	53994294	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:53994294C>A	ENST00000396403.4	+	4	936	c.808C>A	c.(808-810)Cct>Act	p.P270T	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TGGGGAGAAACCTTACAGGTG	0.423000													3	48					0.004672	0.0050606	0.004672	1	0
PTPRJ	5795	broad.mit.edu	37	11	48146544	48146544	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:48146544G>T	ENST00000418331.2	+	6	1251	c.899G>T	c.(898-900)cGg>cTg	p.R300L	PTPRJ_ENST00000440289.2_Missense_Mutation_p.R300L	NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	300	Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GAGAGAAGCCGGGCAGGGAGC	0.587000													40	253					7.05121e-23	1.36806e-22	0.010771	1	0
SMIM8	57150	broad.mit.edu	37	6	88049924	88049924	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:88049924G>T	ENST00000392863.1	+	4	315	c.226G>T	c.(226-228)Gac>Tac	p.D76Y	SMIM8_ENST00000229570.5_Missense_Mutation_p.D76Y	NM_001042493.1	NP_001035958.1			small integral membrane protein 8																		GAATAAAAAGGACCTCTATGA	0.393000													12	22					1.61879e-10	2.55294e-10	0.001368	1	0
LIG1	3978	broad.mit.edu	37	19	48640796	48640796	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:48640796T>A	ENST00000263274.7	-	13	1656	c.1237A>T	c.(1237-1239)Agg>Tgg	p.R413W	LIG1_ENST00000427526.2_Missense_Mutation_p.R382W|LIG1_ENST00000536218.1_Missense_Mutation_p.R345W	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	413					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CCAGTGAGCCTGGCGATGTCG	0.667000								Nucleotide excision repair (NER)					5	15					0	0	0.001984	0	0
ORC1	4998	broad.mit.edu	37	1	52859452	52859452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:52859452G>A	ENST00000371568.3	-	6	963	c.745C>T	c.(745-747)Cag>Tag	p.Q249*	ORC1_ENST00000371566.1_Nonsense_Mutation_p.Q249*	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	249					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GAAGTCTGCTGGGACATCTGA	0.413000													8	26					0	0	0.006214	0	0
LHFPL3	375612	broad.mit.edu	37	7	103969353	103969353	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:103969353C>T	ENST00000535008.1	+	1	250	c.126C>T	c.(124-126)atC>atT	p.I42I	LHFPL3_ENST00000424859.1_Silent_p.I28I|LHFPL3_ENST00000543266.1_Silent_p.I42I|LHFPL3_ENST00000401970.2_Silent_p.I28I			Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	28						integral to membrane				kidney(1)|large_intestine(2)|lung(6)	9						TGTGGGCCATCTTCACCATCT	0.647000													10	25					0	0	0.008291	0	0
TNN	63923	broad.mit.edu	37	1	175097863	175097863	+	Missense_Mutation	SNP	C	C	A	rs113025105	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:175097863C>A	ENST00000239462.4	+	15	3424	c.3311C>A	c.(3310-3312)aCg>aAg	p.T1104K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1104	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GACATGGAAACGGACGGAGGT	0.587000													8	45					0.000274275	0.000316429	0.004482	1	0
TRPS1	7227	broad.mit.edu	37	8	116599565	116599565	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:116599565C>T	ENST00000395715.3	-	5	2940	c.2363G>A	c.(2362-2364)gGg>gAg	p.G788E	TRPS1_ENST00000519076.1_Missense_Mutation_p.G529E|TRPS1_ENST00000519674.1_Missense_Mutation_p.G775E|TRPS1_ENST00000220888.5_Missense_Mutation_p.G775E|TRPS1_ENST00000520276.1_Missense_Mutation_p.G779E	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	775	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTCTTTGAGCCCGTCCTTCTC	0.507000									Langer-Giedion syndrome				128	154					0	0	0.003610	0	0
WDR62	284403	broad.mit.edu	37	19	36562599	36562599	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:36562599G>T	ENST00000401500.2	+	8	1059	c.1024G>T	c.(1024-1026)Gca>Tca	p.A342S	WDR62_ENST00000378860.4_3'UTR|WDR62_ENST00000388999.3_Missense_Mutation_p.A342S|WDR62_ENST00000270301.7_Missense_Mutation_p.A342S	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	342					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTAGACGTGGCACAGGGCCT	0.607000													19	11					3.62473e-10	5.64394e-10	0.012319	1	0
FLG2	388698	broad.mit.edu	37	1	152326860	152326860	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152326860G>T	ENST00000388718.5	-	3	3474	c.3402C>A	c.(3400-3402)ggC>ggA	p.G1134G	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1134	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTTACCTGTGCCTGACCCAT	0.532000													51	174					2.65591e-33	5.31491e-33	0.003610	1	0
FFAR2	2867	broad.mit.edu	37	19	35941285	35941285	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:35941285G>T	ENST00000599180.1	+	2	749	c.669G>T	c.(667-669)ctG>ctT	p.L223L	FFAR2_ENST00000246549.2_Silent_p.L223L|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	223						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCGTGGGGCTGGCTGTGGTGA	0.612000													16	48					1.3612e-06	1.8252e-06	0.003163	1	0
FAM71A	149647	broad.mit.edu	37	1	212798530	212798530	+	Missense_Mutation	SNP	C	C	A	rs144071564	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:212798530C>A	ENST00000294829.3	+	1	742	c.311C>A	c.(310-312)gCc>gAc	p.A104D	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	104										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CATGGCCAGGCCACCAAGAGA	0.547000													24	49					6.21321e-17	1.13986e-16	0.002780	1	0
PRDM15	63977	broad.mit.edu	37	21	43236155	43236155	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:43236155C>A	ENST00000422911.1	-	20	2570	c.2469G>T	c.(2467-2469)aaG>aaT	p.K823N	PRDM15_ENST00000269844.3_Missense_Mutation_p.K1132N|PRDM15_ENST00000398548.1_Missense_Mutation_p.K803N|PRDM15_ENST00000538201.1_Missense_Mutation_p.K786N|PRDM15_ENST00000447207.2_Missense_Mutation_p.K766N			P57071	PRD15_HUMAN	PR domain containing 15	1132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CCTTGTGCAGCTTCATGTGGT	0.627000													13	44					2.27111e-07	3.15096e-07	0.001368	1	0
ALAS2	212	broad.mit.edu	37	X	55052265	55052265	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:55052265T>G	ENST00000330807.5	-	2	306	c.169A>C	c.(169-171)Aag>Cag	p.K57Q	ALAS2_ENST00000335854.4_Missense_Mutation_p.K57Q|ALAS2_ENST00000396198.3_Missense_Mutation_p.K81Q	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	57					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	CCTCCAGCCTTTGTTGCCTTA	0.473000													10	27					0	0	0.010729	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361312	70361312	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:70361312T>A	ENST00000305107.6	-	1	314	c.268A>T	c.(268-270)Atc>Ttc	p.I90F	UGT2B4_ENST00000381096.3_Intron|UGT2B4_ENST00000512583.1_Missense_Mutation_p.I90F|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	90					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						AGCTGCTTGATAATATCCTCA	0.358000													3	17					0	0	0.004672	0	0
SPTBN1	6711	broad.mit.edu	37	2	54859864	54859864	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:54859864C>G	ENST00000333896.5	+	16	4072	c.3687C>G	c.(3685-3687)aaC>aaG	p.N1229K	SPTBN1_ENST00000356805.4_Missense_Mutation_p.N1242K	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1242					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGAACATCAACTCAGATCGCA	0.507000													17	20					0	0	0.007413	0	0
PTH2R	5746	broad.mit.edu	37	2	209302551	209302551	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:209302551G>A	ENST00000272847.2	+	4	569	c.356G>A	c.(355-357)tGg>tAg	p.W119*	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	119						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		AATAAAACATGGGCCAATTAT	0.413000													12	31					0	0	0.010729	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871405	120871405	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:120871405G>A	ENST00000273666.6	+	8	1022	c.751G>A	c.(751-753)Gag>Aag	p.E251K	STXBP5L_ENST00000492541.1_Missense_Mutation_p.E251K|STXBP5L_ENST00000472879.1_Missense_Mutation_p.E251K|STXBP5L_ENST00000497029.1_Missense_Mutation_p.E251K|STXBP5L_ENST00000471454.1_Missense_Mutation_p.E251K	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	251					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TTATTATGATGAGGTAAGTGA	0.353000													8	33					0	0	0.006214	0	0
TNFAIP8L2	79626	broad.mit.edu	37	1	151131197	151131197	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:151131197C>A	ENST00000368910.3	+	2	150	c.24C>A	c.(22-24)agC>agA	p.S8R		NM_024575.4	NP_078851.2	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 2	8					innate immune response					lung(1)|skin(2)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCTCAAAGAGCCTGGCACTGC	0.512000													7	47					0.00307968	0.00338706	0.003080	1	0
RING1	6015	broad.mit.edu	37	6	33179254	33179254	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:33179254G>T	ENST00000374656.4	+	5	983	c.775G>T	c.(775-777)Ggt>Tgt	p.G259C	RING1_ENST00000478431.1_3'UTR	NM_002931.3	NP_002922.2	Q06587	RING1_HUMAN	ring finger protein 1	259	Gly-rich.|Necessary for interaction with CBX2 (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			endometrium(5)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|skin(4)	17						CCCAGAGCCAGGTGGAGAAAT	0.677000													3	11					0.004672	0.0050606	0.004672	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125521572	125521572	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:125521572T>A	ENST00000431078.1	+	16	2742	c.2378T>A	c.(2377-2379)gTc>gAc	p.V793D		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	793	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGAACGCCGTCTCATTTTAT	0.423000													34	55					0	0	0.004289	0	0
CPNE7	27132	broad.mit.edu	37	16	89663001	89663001	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:89663001G>T	ENST00000268720.5	+	17	2004	c.1874G>T	c.(1873-1875)gGa>gTa	p.G625V	CPNE7_ENST00000566398.1_3'UTR|CPNE7_ENST00000319518.8_Missense_Mutation_p.G550V	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	625					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GTCCCTGCCGGAGAGGCCAGC	0.667000													4	41					0.000602214	0.000681505	0.000602	1	0
BCAN	63827	broad.mit.edu	37	1	156617404	156617404	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:156617404C>T	ENST00000329117.4	+	4	907	c.571C>T	c.(571-573)Cag>Tag	p.Q191*	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Nonsense_Mutation_p.Q191*	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	191	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CACCCCGGAGCAGCTCTATGC	0.622000													10	86					0	0	0.008291	0	0
ZNF80	7634	broad.mit.edu	37	3	113955509	113955509	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:113955509C>A	ENST00000482457.2	-	1	916	c.413G>T	c.(412-414)tGt>tTt	p.C138F		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	138						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GGTCTTTCCACACTCGCTGCA	0.512000													9	24					1.58986e-06	2.11859e-06	0.008291	1	0
THBS1	7057	broad.mit.edu	37	15	39884809	39884809	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:39884809A>T	ENST00000260356.5	+	17	2738	c.2573A>T	c.(2572-2574)aAc>aTc	p.N858I		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	858					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ACCTGTGACAACAATCAGGAT	0.443000													5	6					0	0	0.000602	0	0
PEG3	5178	broad.mit.edu	37	19	57325715	57325715	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:57325715T>A	ENST00000326441.9	-	10	4458	c.4095A>T	c.(4093-4095)gcA>gcT	p.A1365A	PEG3_ENST00000598410.1_Silent_p.A1241A|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000593695.1_Silent_p.A1239A|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Silent_p.A1365A|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1365	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ctgctgcagctgctgctgctT	0.468000													13	27					0	0	0.001368	0	0
HBD	3045	broad.mit.edu	37	11	5255238	5255238	+	Missense_Mutation	SNP	C	C	A	rs35329985		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:5255238C>A	ENST00000380299.3	-	2	512	c.298G>T	c.(298-300)Gat>Tat	p.D100Y	HBD_ENST00000292901.3_Missense_Mutation_p.D100Y	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	100			D -> N (in Canada; O(2) affinity up; dbSNP:rs35329985).		blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCTCAGGATCCACGTGCAGC	0.478000													7	36					8.12818e-05	9.70302e-05	0.001984	1	0
MYT1L	23040	broad.mit.edu	37	2	1891331	1891331	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:1891331G>A	ENST00000399161.2	-	17	3318	c.2571C>T	c.(2569-2571)ccC>ccT	p.P857P	MYT1L_ENST00000428368.2_Silent_p.P855P	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	857					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCACCTCCCCGGGATACCGTC	0.502000													57	50					0	0	0.003610	0	0
COL4A5	1287	broad.mit.edu	37	X	107929351	107929351	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:107929351G>T	ENST00000328300.6	+	48	4551	c.4307G>T	c.(4306-4308)gGa>gTa	p.G1436V	COL4A5_ENST00000361603.2_Missense_Mutation_p.G1430V	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1430	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGTCTGCCAGGACAGCCAGGT	0.547000									Alport syndrome with Diffuse Leiomyomatosis				6	15					3.59834e-05	4.44363e-05	0.001168	1	0
TSHZ3	57616	broad.mit.edu	37	19	31769324	31769324	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:31769324G>A	ENST00000240587.4	-	2	1702	c.1375C>T	c.(1375-1377)Cct>Tct	p.P459S		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	459					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					ATGCTGGCAGGTGTATTGGAG	0.552000													4	116					0	0	0.009096	0	0
NPAS2	4862	broad.mit.edu	37	2	101609882	101609882	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:101609882G>T	ENST00000335681.5	+	20	2470	c.2185G>T	c.(2185-2187)Gtc>Ttc	p.V729F	NPAS2_ENST00000542504.1_Missense_Mutation_p.V794F	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	729					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.V729I(1)		cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCCGATGCCCGTCCTGCTGAT	0.652000													20	22					1.01871e-10	1.61547e-10	0.008871	1	0
AHNAK2	113146	broad.mit.edu	37	14	105409436	105409436	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:105409436C>T	ENST00000333244.5	-	7	12471	c.12352G>A	c.(12352-12354)Gac>Aac	p.D4118N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4118						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGGACAGGTCCCCCTCCAGC	0.587000													69	242					0	0	0.003610	0	0
CD200R1	131450	broad.mit.edu	37	3	112648206	112648206	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:112648206C>A	ENST00000471858.1	-	3	514	c.282G>T	c.(280-282)gaG>gaT	p.E94D	CD200R1_ENST00000295863.4_Missense_Mutation_p.E72D|CD200R1_ENST00000308611.3_Missense_Mutation_p.E117D|CD200R1_ENST00000440122.2_Missense_Mutation_p.E117D|CD200R1_ENST00000490004.1_Missense_Mutation_p.E94D	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	94	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TTTCCTTGGTCTCATTTGTTT	0.448000													10	44					6.40141e-05	7.73298e-05	0.010729	1	0
OR6K2	81448	broad.mit.edu	37	1	158670151	158670151	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:158670151G>C	ENST00000359610.2	-	1	335	c.292C>G	c.(292-294)Ctg>Gtg	p.L98V		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TACATCTGCAGGAGACAACCA	0.473000													11	48					0	0	0.008291	0	0
C1orf216	127703	broad.mit.edu	37	1	36181870	36181870	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:36181870G>A	ENST00000270815.4	-	2	823	c.53C>T	c.(52-54)cCa>cTa	p.P18L	C1orf216_ENST00000503824.1_5'UTR	NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	18										kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TCCAGGAGGTGGGTCCCCCAG	0.572000											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	0.003080	0	0
GPR98	84059	broad.mit.edu	37	5	89933730	89933730	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:89933730G>T	ENST00000405460.2	+	11	2301	c.2205G>T	c.(2203-2205)ccG>ccT	p.P735P		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	735	Calx-beta 5.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGACATACCGGAAATGAATG	0.353000													8	30					0.00448238	0.00490153	0.004482	1	0
MUC16	94025	broad.mit.edu	37	19	9090897	9090897	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9090897G>T	ENST00000397910.4	-	1	1121	c.918C>A	c.(916-918)ctC>ctA	p.L306L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	306	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGGGAGGTGAGACTCTGGC	0.498000													21	56					1.9806e-07	2.77026e-07	0.002299	1	0
ENOX1	55068	broad.mit.edu	37	13	43935502	43935502	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:43935502G>T	ENST00000261488.6	-	6	872	c.295C>A	c.(295-297)Ctg>Atg	p.L99M	ENOX1_ENST00000412891.1_Missense_Mutation_p.L99M	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	99	Pro-rich.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGAGGTACCAGTCCAAGGCCT	0.453000													14	22					0.000151284	0.000179598	0.001855	1	0
RRAGD	58528	broad.mit.edu	37	6	90089038	90089038	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:90089038A>T	ENST00000369415.4	-	4	940	c.664T>A	c.(664-666)Tat>Aat	p.Y222N	RRAGD_ENST00000492783.1_5'UTR|RRAGD_ENST00000359203.2_Missense_Mutation_p.Y71N	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	222					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		GAATGATCATATATGCTTGTC	0.373000													5	19					0	0	0.000602	0	0
COL6A3	1293	broad.mit.edu	37	2	238277749	238277749	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:238277749C>A	ENST00000295550.4	-	10	4809	c.4357G>T	c.(4357-4359)Gca>Tca	p.A1453S	COL6A3_ENST00000353578.4_Missense_Mutation_p.A1247S|COL6A3_ENST00000347401.3_Missense_Mutation_p.A1252S|COL6A3_ENST00000346358.4_Missense_Mutation_p.A1253S|COL6A3_ENST00000472056.1_Missense_Mutation_p.A846S|COL6A3_ENST00000409809.1_Missense_Mutation_p.A1247S	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1453	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGAATATGTGCAAAGCCATCT	0.468000													12	11					1.5842e-08	2.33354e-08	0.001855	1	0
NIPBL	25836	broad.mit.edu	37	5	37006617	37006617	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:37006617G>C	ENST00000282516.8	+	17	4513	c.4014G>C	c.(4012-4014)caG>caC	p.Q1338H	NIPBL_ENST00000448238.2_Missense_Mutation_p.Q1338H	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1338					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAGTTATACAGTACACTAAAT	0.338000													3	36					0	0	0.004672	0	0
MATK	4145	broad.mit.edu	37	19	3779011	3779011	+	Silent	SNP	C	C	A	rs140717053	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:3779011C>A	ENST00000310132.6	-	12	1574	c.1176G>T	c.(1174-1176)gcG>gcT	p.A392A	MATK_ENST00000395045.2_Silent_p.A393A|MATK_ENST00000585778.1_Silent_p.A392A|MATK_ENST00000395040.2_Silent_p.A351A	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	392	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCCTCGGGCGCCGTCCACT	0.647000													4	21					0.000602214	0.000681505	0.000602	1	0
OR4K1	79544	broad.mit.edu	37	14	20403925	20403925	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20403925G>C	ENST00000285600.4	+	1	159	c.100G>C	c.(100-102)Gtc>Ctc	p.V34L		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTTCTCTATAGTCTATGTGAC	0.378000													42	173					0	0	0.009718	0	0
BDP1	55814	broad.mit.edu	37	5	70785389	70785389	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:70785389G>T	ENST00000358731.4	+	10	1635	c.1372G>T	c.(1372-1374)Gac>Tac	p.D458Y	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	458	Required for phosphorylation by CSNK2A1.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATTAGAAGTAGACCTAAATCA	0.428000													11	17					1.08611e-07	1.52534e-07	0.010729	1	0
TTN	7273	broad.mit.edu	37	2	179516249	179516249	+	Nonsense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179516249T>A	ENST00000589042.1	-	207	39702	c.39478A>T	c.(39478-39480)Aag>Tag	p.K13160*	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Nonsense_Mutation_p.K11653*|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.K10726*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11513	Ig-like 87.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACCTCCTTGGGCACCTCG	0.443000													4	108					0	0	0.000602	0	0
HOXD9	3235	broad.mit.edu	37	2	176988789	176988789	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:176988789C>T	ENST00000249499.6	+	2	1354	c.945C>T	c.(943-945)cgC>cgT	p.R315R	HOXD-AS2_ENST00000440016.2_RNA	NM_014213.3	NP_055028.3	P28356	HXD9_HUMAN	homeobox D9	315						nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGGACCGGCGCTACGAGGTGG	0.502000													26	89					0	0	0.005443	0	0
EFNB3	1949	broad.mit.edu	37	17	7612491	7612491	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:7612491C>A	ENST00000226091.2	+	5	1017	c.620C>A	c.(619-621)cCc>cAc	p.P207H		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	207					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				CCAGGTGACCCCACCAGCAAT	0.687000													13	23					0.00316338	0.00347245	0.003163	1	0
OR5L2	26338	broad.mit.edu	37	11	55595022	55595022	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55595022A>T	ENST00000378397.1	+	1	328	c.328A>T	c.(328-330)Act>Tct	p.T110S		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				ATGTGGAGTCACTGAGGTCTT	0.493000										HNSCC(27;0.073)			13	58					0	0	0.001368	0	0
SCN4A	6329	broad.mit.edu	37	17	62018185	62018185	+	Silent	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:62018185G>C	ENST00000578147.1	-	24	5533	c.5457C>G	c.(5455-5457)ccC>ccG	p.P1819P	SCN4A_ENST00000435607.1_Silent_p.P1819P			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1819					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGGAGGGGCGGGAGGCCAGG	0.672000													14	51					0	0	0.002450	0	0
LOC440040	440040	broad.mit.edu	37	11	49598243	49598243	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:49598243C>A	ENST00000527477.1	+	0	847																											GTCATTGGGCCTGGTTCCAGT	0.502000													3	25					3.59834e-05	4.44363e-05	0.001168	1	0
PALLD	23022	broad.mit.edu	37	4	169846183	169846183	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:169846183G>C	ENST00000335742.7	+	20	4144	c.2787G>C	c.(2785-2787)aaG>aaC	p.K929N	PALLD_ENST00000261509.6_Missense_Mutation_p.K1087N|PALLD_ENST00000505667.1_Missense_Mutation_p.K1104N|PALLD_ENST00000512127.1_Missense_Mutation_p.K705N|CBR4_ENST00000509108.1_Intron|PALLD_ENST00000507735.1_Missense_Mutation_p.K600N			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1311					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGTCAGCCAAGAATGAAGCAG	0.463000									Pancreatic Cancer, Familial Clustering of				8	39					0	0	0.004482	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813782	106813782	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:106813782C>A	ENST00000407775.2	+	8	1722	c.1472C>A	c.(1471-1473)tCt>tAt	p.S491Y	RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S222Y|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S359Y|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S359Y|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	491					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ATTGGGCCTTCTTTCCCTGTG	0.443000													17	90					3.32936e-07	4.57487e-07	0.006122	1	0
KIF21B	23046	broad.mit.edu	37	1	200971298	200971298	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:200971298C>A	ENST00000332129.2	-	9	1709	c.1393G>T	c.(1393-1395)Gcc>Tcc	p.A465S	KIF21B_ENST00000461742.2_Missense_Mutation_p.A465S|KIF21B_ENST00000360529.5_Missense_Mutation_p.A465S|KIF21B_ENST00000422435.2_Missense_Mutation_p.A465S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	465					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CCGGCCTTGGCTAGCAGCAGG	0.642000													21	26					1.01871e-10	1.61547e-10	0.008871	1	0
TPR	7175	broad.mit.edu	37	1	186342569	186342569	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:186342569T>A	ENST00000367478.3	-	2	474	c.178A>T	c.(178-180)Agg>Tgg	p.R60W	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	60					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGGGACAACCTCTTTTCTATT	0.348000			T	NTRK1	papillary thyroid								4	30					0	0	0.000602	0	0
DSCR9	257203	broad.mit.edu	37	21	38593547	38593547	+	RNA	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:38593547G>A	ENST00000454482.2	+	0	1154					NR_026719.2																						GTATAGACGAGCCCATGTCTG	0.716000											OREG0026204	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	37					0	0	0.006214	0	0
GSTM5	2949	broad.mit.edu	37	1	110257957	110257957	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:110257957C>A	ENST00000369813.1	+	5	1444	c.539C>A	c.(538-540)tCg>tAg	p.S180*	GSTM5_ENST00000492718.1_3'UTR|GSTM5_ENST00000256593.3_Intron|GSTM5_ENST00000369812.5_Intron			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	aagaataactcgtatgtattg	0.448000													6	8					3.59834e-05	4.44363e-05	0.001168	1	0
BFSP2	8419	broad.mit.edu	37	3	133118939	133118939	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:133118939G>A	ENST00000302334.2	+	1	101	c.12G>A	c.(10-12)agG>agA	p.R4R		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	4	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						TGAGTGAGAGGCGAGTGGTAG	0.622000													4	60					0	0	0.009096	0	0
ZNF157	7712	broad.mit.edu	37	X	47269737	47269737	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:47269737C>A	ENST00000377073.3	+	2	221	c.135C>A	c.(133-135)gaC>gaA	p.D45E		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	45	KRAB.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						ACAGACTGGACCCTGCTCAGA	0.527000													24	42					5.35356e-11	8.56071e-11	0.002780	1	0
REM1	28954	broad.mit.edu	37	20	30064472	30064472	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:30064472G>T	ENST00000201979.2	+	2	517	c.224G>T	c.(223-225)gGc>gTc	p.G75V	DEFB124_ENST00000481595.1_5'UTR	NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	75					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GACTCTGAAGGCTCCTGGGAG	0.597000													22	37					2.37509e-13	4.0787e-13	0.010504	1	0
TCP10L2	401285	broad.mit.edu	37	6	167592025	167592025	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:167592025G>C	ENST00000366832.2	+	5	783	c.652G>C	c.(652-654)Gga>Cga	p.G218R		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	218										endometrium(1)|kidney(2)|lung(3)	6						GTCTGAAGACGGAAAGGTGAC	0.507000													7	90					0	0	0.006214	0	0
SESN2	83667	broad.mit.edu	37	1	28598184	28598184	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:28598184G>T	ENST00000253063.3	+	3	477		c.e3-1			NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2						cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGTTGGCAGGTCCTTCGGG	0.567000													18	21					6.94344e-10	1.06951e-09	0.006122	1	0
WDR7	23335	broad.mit.edu	37	18	54688028	54688028	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:54688028G>T	ENST00000254442.3	+	27	4428	c.4217G>T	c.(4216-4218)gGa>gTa	p.G1406V	WDR7_ENST00000357574.3_Missense_Mutation_p.G1373V|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	1406										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		GCTCCTGATGGAAGATATCTT	0.413000													13	64					0.000151284	0.000179598	0.001855	1	0
ALOX5	240	broad.mit.edu	37	10	45941035	45941035	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:45941035T>G	ENST00000374391.2	+	14	1978	c.1925T>G	c.(1924-1926)cTc>cGc	p.L642R	ALOX5_ENST00000542434.1_Missense_Mutation_p.L585R|RP11-67C2.2_ENST00000435635.1_RNA	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	642	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CGCAAGAACCTCGAGGCCATT	0.537000													15	40					0	0	0.002450	0	0
PCDH8	5100	broad.mit.edu	37	13	53418746	53418746	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:53418746G>T	ENST00000377942.3	-	3	3365	c.3162C>A	c.(3160-3162)tcC>tcA	p.S1054S	PCDH8_ENST00000338862.4_Silent_p.S957S	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	1054					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TGCCAGGAGGGGACTGGTAGA	0.562000													14	63					2.61681e-11	4.23569e-11	0.002450	1	0
GLRB	2743	broad.mit.edu	37	4	158091864	158091864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:158091864G>A	ENST00000264428.4	+	10	1748	c.1478G>A	c.(1477-1479)tGg>tAg	p.W493*	GLRB_ENST00000512619.1_3'UTR|GLRB_ENST00000509282.1_Nonsense_Mutation_p.W493*|GLRB_ENST00000541722.1_3'UTR	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	493					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GTTATATATTGGTCTATATAT	0.338000													3	32					0	0	0.004672	0	0
VAV3	10451	broad.mit.edu	37	1	108507484	108507484	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:108507484G>T	ENST00000370056.4	-	1	282	c.8C>A	c.(7-9)cCg>cAg	p.P3Q	VAV3-AS1_ENST00000438318.1_RNA|VAV3_ENST00000527011.1_Missense_Mutation_p.P3Q	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	3	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CTGCTTCCACGGCTCCATGCC	0.746000													4	7					0.00198382	0.00219304	0.001984	1	0
CDH18	1016	broad.mit.edu	37	5	19612661	19612661	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:19612661A>T	ENST00000507958.1	-	8	1683	c.693T>A	c.(691-693)caT>caA	p.H231Q	CDH18_ENST00000511273.1_Missense_Mutation_p.H231Q|CDH18_ENST00000502796.1_Missense_Mutation_p.H231Q|CDH18_ENST00000506372.1_Missense_Mutation_p.H231Q|CDH18_ENST00000274170.4_Missense_Mutation_p.H231Q|CDH18_ENST00000382275.1_Missense_Mutation_p.H231Q			Q13634	CAD18_HUMAN	cadherin 18, type 2	231	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTACGGAGTAATGTTCTCTGG	0.393000													11	81					0	0	0.001368	0	0
RYR2	6262	broad.mit.edu	37	1	237802473	237802473	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:237802473T>A	ENST00000366574.2	+	46	7404	c.7087T>A	c.(7087-7089)Tca>Aca	p.S2363T	RYR2_ENST00000542537.1_Missense_Mutation_p.S2347T|RYR2_ENST00000360064.6_Missense_Mutation_p.S2361T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2363	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGATGGTCCCTCACCAAATAG	0.443000													3	21					0	0	0.009096	0	0
OR2T33	391195	broad.mit.edu	37	1	248436766	248436766	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248436766G>T	ENST00000318021.2	-	1	372	c.351C>A	c.(349-351)gcC>gcA	p.A117A		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGCGGTCATAGGCCATGGCTG	0.597000													9	75					0.000978159	0.00110043	0.010729	1	0
SSPO	23145	broad.mit.edu	37	7	149477177	149477177	+	RNA	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:149477177A>T	ENST00000378016.2	+	0	1354							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCTGTGCCAGGCGGCACAT	0.657000													4	9					0	0	0.009096	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397300	5397300	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:5397300C>G	ENST00000341928.2	-	18	2938	c.2598G>C	c.(2596-2598)gcG>gcC	p.A866A	EPB41L3_ENST00000544123.1_Silent_p.A697A|EPB41L3_ENST00000342933.3_Silent_p.A866A|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000540638.2_Silent_p.A644A|EPB41L3_ENST00000400111.3_Silent_p.A644A|EPB41L3_ENST00000427684.2_Silent_p.A163A|EPB41L3_ENST00000542146.1_Silent_p.A171A	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	866	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CATCCCCACTCGCGTGCACCA	0.617000													8	45					0	0	0.004482	0	0
XYLT1	64131	broad.mit.edu	37	16	17353101	17353101	+	Silent	SNP	G	G	T	rs146043560	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:17353101G>T	ENST00000261381.6	-	3	741	c.657C>A	c.(655-657)ccC>ccA	p.P219P		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	219					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTCTGTCCCCGGGAGGCAGCA	0.587000													28	132					5.61819e-17	1.0318e-16	0.005443	1	0
XPNPEP1	7511	broad.mit.edu	37	10	111639976	111639976	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:111639976G>T	ENST00000369680.4	-	12	1271	c.1023C>A	c.(1021-1023)ctC>ctA	p.L341L	XPNPEP1_ENST00000322238.8_Silent_p.L384L|XPNPEP1_ENST00000502935.1_Silent_p.L384L|XPNPEP1_ENST00000369683.1_Silent_p.L270L	NM_020383.3	NP_065116.3	Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	341					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		AGAGTTCACAGAGAGCAACAG	0.368000													10	54					2.68362e-12	4.47878e-12	0.001368	1	0
KDM3B	51780	broad.mit.edu	37	5	137708510	137708510	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:137708510A>T	ENST00000314358.5	+	2	540	c.340A>T	c.(340-342)Att>Ttt	p.I114F		NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	114					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TCGAGTCTCCATTGCACAATG	0.498000													11	12					0	0	0.001368	0	0
ANK2	287	broad.mit.edu	37	4	114276613	114276613	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:114276613C>A	ENST00000357077.4	+	38	6892	c.6839C>A	c.(6838-6840)cCc>cAc	p.P2280H	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P2247H	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2247					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAGAGCATCCCACGACCAAA	0.468000													11	33					0.000673444	0.000759613	0.008291	1	0
CASP8	841	broad.mit.edu	37	2	202149719	202149719	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:202149719G>T	ENST00000358485.4	+	8	1356	c.1160G>T	c.(1159-1161)gGa>gTa	p.G387V	CASP8_ENST00000264274.9_Missense_Mutation_p.G244V|CASP8_ENST00000264275.5_Missense_Mutation_p.G345V|CASP8_ENST00000323492.7_Missense_Mutation_p.G313V|CASP8_ENST00000432109.2_Missense_Mutation_p.G328V|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000392259.2_3'UTR	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	328					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GGCACTGATGGACAGGAGGCC	0.468000										HNSCC(4;0.00038)			38	91					1.03484e-13	1.78603e-13	0.005524	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735707	55735707	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55735707G>C	ENST00000312345.2	-	1	283	c.233C>G	c.(232-234)aCt>aGt	p.T78S		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					TCCTTTCTGAGTCCAAATGTC	0.383000													6	44					0	0	0.001168	0	0
HEATR2	54919	broad.mit.edu	37	7	803466	803466	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:803466G>T	ENST00000297440.6	+	8	1658	c.1638G>T	c.(1636-1638)ctG>ctT	p.L546L	HEATR2_ENST00000313147.5_Silent_p.L546L	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	546							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TGGACTCACTGGCCATGGTGG	0.602000													13	78					1.05317e-09	1.61211e-09	0.002450	1	0
GXYLT2	727936	broad.mit.edu	37	3	73016750	73016750	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:73016750G>T	ENST00000389617.4	+	6	1190	c.1029G>T	c.(1027-1029)atG>atT	p.M343I		NM_001080393.1	NP_001073862.1	A0PJZ3	GXLT2_HUMAN	glucoside xylosyltransferase 2	343					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	18						ATCACTGCATGTACGGAAGCA	0.502000													3	15					0.00909568	0.00969341	0.009096	1	0
GPR112	139378	broad.mit.edu	37	X	135426568	135426568	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:135426568A>G	ENST00000394143.1	+	6	994	c.703A>G	c.(703-705)Aca>Gca	p.T235A	GPR112_ENST00000370652.1_Missense_Mutation_p.T235A|GPR112_ENST00000287534.4_Missense_Mutation_p.T172A|GPR112_ENST00000412101.1_Missense_Mutation_p.T30A|GPR112_ENST00000394141.1_Missense_Mutation_p.T30A	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	235					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGAAAATATGACAATTCAAGA	0.318000													5	11					0	0	0.000602	0	0
SLIT3	6586	broad.mit.edu	37	5	168310292	168310292	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:168310292C>A	ENST00000519560.1	-	5	882	c.463G>T	c.(463-465)Ggc>Tgc	p.G155C	SLIT3_ENST00000404867.3_Missense_Mutation_p.G155C|SLIT3_ENST00000332966.8_Missense_Mutation_p.G155C	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	155					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGGTGATGCCGCGGAACGCC	0.502000													10	21					3.86212e-05	4.72862e-05	0.008291	1	0
SBF1	6305	broad.mit.edu	37	22	50894717	50894717	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:50894717T>A	ENST00000380817.2	-	31	4377	c.4194A>T	c.(4192-4194)ccA>ccT	p.P1398P	SBF1_ENST00000390679.3_Silent_p.P1372P|SBF1_ENST00000348911.6_Silent_p.P1373P	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1372	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGGCAGCCTGGGACACATG	0.637000													4	12					0	0	0.009096	0	0
CHST12	55501	broad.mit.edu	37	7	2473087	2473087	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:2473087C>T	ENST00000258711.6	+	2	948	c.813C>T	c.(811-813)gcC>gcT	p.A271A		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	271					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GCAAGTTCGCCGTGCCCATGC	0.647000													19	68					0	0	0.007413	0	0
CLEC16A	23274	broad.mit.edu	37	16	11056400	11056400	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:11056400A>T	ENST00000409790.1	+	3	528	c.298A>T	c.(298-300)Acc>Tcc	p.T100S	CLEC16A_ENST00000409552.3_Missense_Mutation_p.T100S	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	100										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GCTGCTGCAGACCTTGAACAT	0.478000													61	89					0	0	0.003610	0	0
IGHV3OR15-7	28318	broad.mit.edu	37	15	20193360	20193360	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:20193360C>A	ENST00000558565.2	-	0	10																											CCAGCTCAGCCCAAACTCCAT	0.493000													23	71					1.55469e-16	2.83406e-16	0.003330	1	0
IRS4	8471	broad.mit.edu	37	X	107976275	107976275	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:107976275G>A	ENST00000372129.2	-	1	3376	c.3300C>T	c.(3298-3300)gtC>gtT	p.V1100V		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	1100	Ala-rich.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GAAAAGCAGAGACAGCGGCTC	0.572000													8	90					0	0	0.002450	0	0
SEMA5A	9037	broad.mit.edu	37	5	9136667	9136667	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:9136667C>T	ENST00000382496.5	-	13	2213	c.1548G>A	c.(1546-1548)ctG>ctA	p.L516L		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	516					cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGCTCTCCTCCAGGCTTGTGC	0.552000													23	111					0	0	0.002299	0	0
TTN	7273	broad.mit.edu	37	2	179499928	179499928	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179499928T>C	ENST00000589042.1	-	228	42212	c.41988A>G	c.(41986-41988)caA>caG	p.Q13996Q	TTN_ENST00000342175.6_Silent_p.Q5123Q|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Silent_p.Q4931Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Silent_p.Q5056Q|TTN_ENST00000591111.1_Silent_p.Q12355Q|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.Q11428Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12355	Ig-like 95.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTTTCCATTGTCCAGGAA	0.373000													13	154					0	0	0.002450	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090699	238090699	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:238090699C>A	ENST00000450451.1	+	0	2205					NR_027247.2																						TGACAGGCTACCTCATGAAGA	0.617000													3	19					0.004672	0.0050606	0.004672	1	0
BCLAF1	9774	broad.mit.edu	37	6	136597197	136597197	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:136597197G>C	ENST00000531224.1	-	5	1718	c.1466C>G	c.(1465-1467)aCa>aGa	p.T489R	BCLAF1_ENST00000527536.1_Missense_Mutation_p.T489R|BCLAF1_ENST00000392348.2_Missense_Mutation_p.T487R|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000353331.4_Missense_Mutation_p.T487R|BCLAF1_ENST00000527759.1_Missense_Mutation_p.T487R	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	489					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTTCTTTACTGTTATTCTTTC	0.368000													14	106					0	0	0.001855	0	0
TECTA	7007	broad.mit.edu	37	11	121016361	121016361	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:121016361G>T	ENST00000392793.1	+	12	3912	c.3641G>T	c.(3640-3642)gGc>gTc	p.G1214V	TECTA_ENST00000264037.2_Missense_Mutation_p.G1214V|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1214	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACTGATTTTGGCCTGAAGGTT	0.517000													7	101					8.12818e-05	9.70302e-05	0.001984	1	0
SSPO	23145	broad.mit.edu	37	7	149493717	149493717	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:149493717G>T	ENST00000378016.2	+	0	6713							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAGGGGTTGGACTCCGCTGT	0.657000													17	21					1.02788e-11	1.68119e-11	0.004990	1	0
TTN	7273	broad.mit.edu	37	2	179474428	179474428	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179474428T>A	ENST00000589042.1	-	272	51946	c.51722A>T	c.(51721-51723)aAa>aTa	p.K17241I	TTN_ENST00000342175.6_Missense_Mutation_p.K8368I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K8176I|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.K8301I|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K15600I|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K14673I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15600							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTACAGCTTTGGTTGGAGG	0.418000													31	262					0	0	0.008361	0	0
PAN2	9924	broad.mit.edu	37	12	56726626	56726626	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:56726626C>A	ENST00000425394.2	-	2	629	c.253G>T	c.(253-255)Gag>Tag	p.E85*	PAN2_ENST00000257931.5_Nonsense_Mutation_p.E85*|PAN2_ENST00000440411.3_Nonsense_Mutation_p.E85*|PAN2_ENST00000548043.1_Nonsense_Mutation_p.E85*	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	85					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGCATCTCCTCGTGCAAGTCA	0.512000													21	67					1.55795e-14	2.75809e-14	0.012319	1	0
ATAD3A	55210	broad.mit.edu	37	1	1463089	1463089	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:1463089T>C	ENST00000378755.5	+	14	1590	c.1496T>C	c.(1495-1497)cTg>cCg	p.L499P	ATAD3A_ENST00000378756.3_Missense_Mutation_p.L451P|ATAD3A_ENST00000536055.1_Missense_Mutation_p.L372P	NM_018188.3	NP_060658.3	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	499							ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(4)|kidney(6)|large_intestine(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		ATGCTGGTCCTGGCCAGCAAC	0.657000													9	43					0	0	0.004482	0	0
MUC16	94025	broad.mit.edu	37	19	9048196	9048196	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9048196T>A	ENST00000397910.4	-	5	33638	c.33435A>T	c.(33433-33435)tcA>tcT	p.S11145S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11147	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACCTCAGGTGAAACAGTTA	0.458000													5	41					0	0	0.000602	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764098	92764098	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:92764098A>G	ENST00000318238.4	-	5	2403	c.1187T>C	c.(1186-1188)cTa>cCa	p.L396P	SAMD9L_ENST00000437805.1_Missense_Mutation_p.L396P|SAMD9L_ENST00000411955.1_Missense_Mutation_p.L396P	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	396										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AACCAGCTTTAGTCCTTCACT	0.363000													29	142					0	0	0.007291	0	0
OR4D2	124538	broad.mit.edu	37	17	56247175	56247175	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:56247175C>A	ENST00000545221.1	+	1	159	c.159C>A	c.(157-159)tcC>tcA	p.S53S		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						CCTCTGATTCCCAGCTCCACA	0.488000													22	151					1.66031e-10	2.61601e-10	0.003954	1	0
CACNA1S	779	broad.mit.edu	37	1	201046249	201046249	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:201046249C>T	ENST00000362061.3	-	12	1852	c.1626G>A	c.(1624-1626)tgG>tgA	p.W542*	CACNA1S_ENST00000367338.3_Nonsense_Mutation_p.W542*	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	542					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCAGCGACGTCCAATATCTGA	0.597000													11	19					0	0	0.010729	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280557	122280557	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:122280557C>A	ENST00000398250.1	+	5	747	c.395C>A	c.(394-396)cCc>cAc	p.P132H	PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.P122H|PPAPDC1A_ENST00000439221.1_Intron|PPAPDC1A_ENST00000398248.1_Intron|PPAPDC1A_ENST00000541332.1_Missense_Mutation_p.P132H	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	132					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		ACAGGTGACCCCGATCTGGTG	0.512000													14	42					4.7546e-09	7.13813e-09	0.004007	1	0
SLC26A5	375611	broad.mit.edu	37	7	103048298	103048298	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:103048298C>T	ENST00000306312.3	-	8	1149	c.888_splice	c.e8+1	p.A296_splice	SLC26A5_ENST00000393730.1_Splice_Site_p.A296_splice|SLC26A5_ENST00000356767.4_Splice_Site_p.A296_splice|SLC26A5_ENST00000393735.2_Splice_Site_p.A296_splice|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000432958.2_Splice_Site_p.A296_splice|SLC26A5_ENST00000339444.6_Splice_Site_p.A296_splice|SLC26A5_ENST00000393727.1_Splice_Site_p.A296_splice|SLC26A5_ENST00000393729.1_Splice_Site_p.A259_splice|SLC26A5_ENST00000393723.1_Splice_Site_p.A296_splice	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	296					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						GGTGACTTACCGCAAAGAACT	0.438000													5	74					0	0	0.001168	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38609996	38609996	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:38609996C>T	ENST00000222345.6	+	9	2851	c.2342C>T	c.(2341-2343)cCc>cTc	p.P781L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	781	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCCCCATCCCCAGTGGAACC	0.542000													10	54					0	0	0.001368	0	0
ZP1	22917	broad.mit.edu	37	11	60637239	60637239	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:60637239T>C	ENST00000278853.5	+	3	548	c.548T>C	c.(547-549)cTg>cCg	p.L183P		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	183					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CCCAGCCCACTGGACCCAGGG	0.632000													4	23					0	0	0.000602	0	0
CABYR	26256	broad.mit.edu	37	18	21735744	21735744	+	Silent	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:21735744T>C	ENST00000399496.3	+	4	444	c.279T>C	c.(277-279)tcT>tcC	p.S93S	CABYR_ENST00000399481.2_5'UTR|CABYR_ENST00000415309.2_Silent_p.S93S|CABYR_ENST00000399499.1_Silent_p.S93S|CABYR_ENST00000327201.6_5'UTR|CABYR_ENST00000581397.1_Silent_p.S93S	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	93					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					CTGTAGAATCTAAAGTACCTA	0.378000													27	26					0	0	0.006320	0	0
PCDH17	27253	broad.mit.edu	37	13	58207659	58207659	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:58207659G>T	ENST00000377918.3	+	1	1005	c.979G>T	c.(979-981)Ggg>Tgg	p.G327W		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	327	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCGAGACCTGGGGCCTAACCC	0.602000													8	52					0.000274275	0.000316429	0.004482	1	0
OR5D18	219438	broad.mit.edu	37	11	55587679	55587679	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55587679G>T	ENST00000333976.4	+	1	594	c.574G>T	c.(574-576)Gat>Tat	p.D192Y		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D192Y(1)		NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TTCTTGCTCTGATACTTACAT	0.403000													43	93					6.57855e-14	1.15041e-13	0.009718	1	0
HMCN1	83872	broad.mit.edu	37	1	186059943	186059943	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:186059943G>T	ENST00000271588.4	+	64	10010	c.9781G>T	c.(9781-9783)Gga>Tga	p.G3261*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.G3261*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3261	Ig-like C2-type 31.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTCCTTCTAGGAGAAAATGT	0.398000													12	39					2.27111e-07	3.15096e-07	0.001368	1	0
TXK	7294	broad.mit.edu	37	4	48069685	48069685	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:48069685C>A	ENST00000264316.4	-	15	1638	c.1553G>T	c.(1552-1554)cGg>cTg	p.R518L	TXK_ENST00000507351.1_Missense_Mutation_p.R173L	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	518	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity	p.R518L(1)		breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						TGTGACAGCCCGCAGCAGCTC	0.483000													19	100					8.10497e-08	1.15622e-07	0.010504	1	0
GRM1	2911	broad.mit.edu	37	6	146480667	146480667	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:146480667C>A	ENST00000392299.2	+	3	1354	c.884C>A	c.(883-885)aCa>aAa	p.T295K	GRM1_ENST00000507907.1_Missense_Mutation_p.T295K|GRM1_ENST00000355289.4_Missense_Mutation_p.T295K|GRM1_ENST00000492807.2_Missense_Mutation_p.T295K|GRM1_ENST00000361719.2_Missense_Mutation_p.T295K|GRM1_ENST00000282753.1_Missense_Mutation_p.T295K			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	295					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GAAGGCATGACAGTGCGAGGA	0.562000													24	37					6.12954e-19	1.15155e-18	0.004656	1	0
ZNF827	152485	broad.mit.edu	37	4	146806953	146806953	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:146806953C>A	ENST00000508784.1	-	4	1851	c.1624G>T	c.(1624-1626)Gac>Tac	p.D542Y	ZNF827_ENST00000379448.4_Missense_Mutation_p.D542Y|ZNF827_ENST00000513320.1_Missense_Mutation_p.D192Y			Q17R98	ZN827_HUMAN	zinc finger protein 827	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					GCGGGCCTGTCGGCAGCATTC	0.572000													13	39					4.93089e-13	8.42565e-13	0.002450	1	0
EXT2	2132	broad.mit.edu	37	11	44129620	44129620	+	Missense_Mutation	SNP	G	G	T	rs115948531	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:44129620G>T	ENST00000395673.3	+	2	513	c.457G>T	c.(457-459)Gtc>Ttc	p.V153F	EXT2_ENST00000358681.4_Missense_Mutation_p.V120F|EXT2_ENST00000533608.1_Missense_Mutation_p.V120F|EXT2_ENST00000343631.3_Missense_Mutation_p.V120F|EXT2_ENST00000529186.1_3'UTR	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	120					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						TGACTTTGGCGTCTCTGTCAG	0.458000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				18	30					1.50039e-11	2.44009e-11	0.012319	1	0
KPNA6	23633	broad.mit.edu	37	1	32627617	32627617	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:32627617A>T	ENST00000373625.3	+	8	810	c.717A>T	c.(715-717)cgA>cgT	p.R239R	KPNA6_ENST00000545542.1_Silent_p.R244R|KPNA6_ENST00000537234.1_Silent_p.R236R|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	239	NLS binding site (major) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				ATCTCTGCCGAGGGAAAAACC	0.498000													11	14					0	0	0.001368	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100533317	100533317	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:100533317C>T	ENST00000268070.4	-	20	2990	c.2885G>A	c.(2884-2886)aGa>aAa	p.R962K		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	962	TSP type-1 4.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTCCTCGGCTCTCGGCCTCGT	0.612000													13	28					0	0	0.001368	0	0
FAM47B	170062	broad.mit.edu	37	X	34961513	34961513	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:34961513C>A	ENST00000329357.5	+	1	601	c.565C>A	c.(565-567)Ccg>Acg	p.P189T		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	189	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GGAATCCTGCCCGCGGCCTCC	0.647000													11	19					1.58986e-06	2.11859e-06	0.008291	1	0
DEPTOR	64798	broad.mit.edu	37	8	121021350	121021350	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:121021350C>T	ENST00000286234.5	+	8	1209	c.1079C>T	c.(1078-1080)cCt>cTt	p.P360L	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Missense_Mutation_p.P259L	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	360	PDZ.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						CCCAGTGGCCCTGCAGCCGCA	0.507000													27	32					0	0	0.003954	0	0
CASZ1	54897	broad.mit.edu	37	1	10711081	10711081	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:10711081C>A	ENST00000377022.3	-	12	3050	c.2733G>T	c.(2731-2733)ccG>ccT	p.P911P	CASZ1_ENST00000344008.5_Silent_p.P911P|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	911					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CACCGGGTTCCGGCTTCACTT	0.701000													3	16					6.4e-05	7.73298e-05	0.004672	1	0
ADAM32	203102	broad.mit.edu	37	8	39044509	39044509	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:39044509G>T	ENST00000379907.4	+	11	1124	c.997G>T	c.(997-999)Gac>Tac	p.D333Y	ADAM32_ENST00000519315.1_Intron|ADAM32_ENST00000437682.2_Intron	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	333	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			ATCATATGACGACCCAAAGAA	0.348000													9	25					5.4927e-09	8.18194e-09	0.004482	1	0
PTTG2	10744	broad.mit.edu	37	4	37962214	37962214	+	Silent	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:37962214A>G	ENST00000504686.1	+	1	159	c.159A>G	c.(157-159)ccA>ccG	p.P53P	TBC1D1_ENST00000508802.1_Intron|TBC1D1_ENST00000261439.4_Intron	NM_006607.2	NP_006598.2	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	53					chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding			breast(1)|endometrium(1)|lung(4)|skin(1)	7						ACGATGCTCCATCAGCCTTAC	0.433000													16	38					0	0	0.003163	0	0
GALNT18	374378	broad.mit.edu	37	11	11470442	11470442	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:11470442T>C	ENST00000227756.4	-	2	688	c.277A>G	c.(277-279)Aca>Gca	p.T93A		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		GAGGAGTCTGTGAAGGGCTCG	0.612000													5	2					0	0	0.000602	0	0
SNHG14	104472715	broad.mit.edu	37	15	25342831	25342831	+	RNA	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:25342831T>A	ENST00000546682.1	+	0	1229				SNHG14_ENST00000549804.2_RNA|SNORD116-25_ENST00000516517.1_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						GACTTTAAAATGGATCTCATC	0.478000													11	18					0	0	0.001368	0	0
OGDH	4967	broad.mit.edu	37	7	44664004	44664004	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:44664004A>C	ENST00000222673.5	+	2	104	c.62A>C	c.(61-63)aAg>aCg	p.K21T	OGDH_ENST00000444676.1_Missense_Mutation_p.K21T|OGDH_ENST00000443864.2_Missense_Mutation_p.K21T|OGDH_ENST00000439616.2_Missense_Mutation_p.K21T|OGDH_ENST00000447398.1_Missense_Mutation_p.K21T|OGDH_ENST00000449767.1_Missense_Mutation_p.K21T	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	21					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CAGACTGTTAAGACATTTTCA	0.438000													77	36					0	0	0.003610	0	0
ERCC4	2072	broad.mit.edu	37	16	14029051	14029051	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:14029051G>A	ENST00000311895.7	+	8	1271	c.1262G>A	c.(1261-1263)aGa>aAa	p.R421K	CTD-2135D7.2_ENST00000575137.1_RNA|CTD-2135D7.2_ENST00000570663.1_RNA	NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	421					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						TCCCAGCTGAGAGACTATATC	0.413000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				17	46					0	0	0.007413	0	0
GZMH	2999	broad.mit.edu	37	14	25077587	25077587	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:25077587G>T	ENST00000216338.4	-	2	131	c.87C>A	c.(85-87)ccC>ccA	p.P29P	GZMH_ENST00000557220.2_Silent_p.P29P|GZMH_ENST00000382548.4_Silent_p.P29P|RP11-104E19.1_ENST00000557736.1_RNA|RP11-104E19.1_ENST00000555300.1_RNA	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	29	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		GGCGGGAGTGGGGCTTGGCCT	0.547000													11	101					4.3838e-07	5.98551e-07	0.001855	1	0
ZNF484	83744	broad.mit.edu	37	9	95608877	95608877	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:95608877T>C	ENST00000395505.2	-	3	2176	c.2084A>G	c.(2083-2085)cAg>cGg	p.Q695R	ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000375495.3_Missense_Mutation_p.Q731R|ZNF484_ENST00000395506.3_Missense_Mutation_p.Q733R|ZNF484_ENST00000332591.6_Missense_Mutation_p.Q695R	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						GTGTGACTTCTGGATGAAGGA	0.378000													11	33					0	0	0.008291	0	0
NFATC3	4775	broad.mit.edu	37	16	68156795	68156795	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:68156795C>T	ENST00000349223.5	+	2	1233	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S	NFATC3_ENST00000575270.1_Missense_Mutation_p.P337S|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.P337S|NFATC3_ENST00000329524.4_Missense_Mutation_p.P337S	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	337					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GACTGACATCCCTCTCAAAAC	0.473000													25	97					0	0	0.003330	0	0
F8	2157	broad.mit.edu	37	X	154132669	154132669	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:154132669T>C	ENST00000360256.4	-	17	5917	c.5717A>G	c.(5716-5718)aAa>aGa	p.K1906R		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1906	F5/8 type A 3.|Plastocyanin-like 6.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GTACCAGCTTTTGGTCTCATC	0.448000													51	68					0	0	0.003610	0	0
PSG11	5680	broad.mit.edu	37	19	43519313	43519313	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:43519313C>G	ENST00000401740.1	-	4	1022	c.919G>C	c.(919-921)Gcc>Ccc	p.A307P	PSG11_ENST00000403486.1_Missense_Mutation_p.A185P|PSG11_ENST00000320078.7_Missense_Mutation_p.A307P|PSG11_ENST00000306322.7_Missense_Mutation_p.A185P			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	307	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				TCGCCAGTGGCTGAGTTACGA	0.458000													85	43					0	0	0.003610	0	0
GRIK1	2897	broad.mit.edu	37	21	31045395	31045395	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:31045395C>A	ENST00000399914.1	-	4	1155	c.634G>T	c.(634-636)Gcc>Tcc	p.A212S	GRIK1_ENST00000389125.3_Missense_Mutation_p.A212S|GRIK1_ENST00000535441.1_Missense_Mutation_p.A212S|GRIK1_ENST00000327783.4_Missense_Mutation_p.A212S|GRIK1_ENST00000399909.1_Missense_Mutation_p.A212S|GRIK1_ENST00000399913.1_Missense_Mutation_p.A212S|GRIK1_ENST00000309434.7_Missense_Mutation_p.A212S|GRIK1_ENST00000399907.1_Missense_Mutation_p.A212S|GRIK1_ENST00000389124.2_Missense_Mutation_p.A212S|GRIK1_ENST00000472429.1_5'UTR			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	212					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AAAGGCTTGGCATCTTTATTC	0.408000													58	77					1.4709e-25	2.9063e-25	0.003610	1	0
ZNF606	80095	broad.mit.edu	37	19	58490783	58490783	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:58490783T>A	ENST00000341164.4	-	7	1885	c.1265A>T	c.(1264-1266)cAt>cTt	p.H422L	ZNF606_ENST00000536132.1_Missense_Mutation_p.H332L	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H422R(2)		NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TTCTCCAGTATGAGTTTTCTT	0.398000													22	11					0	0	0.010504	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41447987	41447987	+	RNA	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:41447987C>G	ENST00000599198.1	+	0	894					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						CCAACCCACACAGTGAATTCA	0.592000													5	23					0	0	0.001984	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090683	238090683	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:238090683G>T	ENST00000450451.1	+	0	2189					NR_027247.2																						CTGGCTGGCAGGGACCTGACA	0.622000													11	13					3.07112e-06	4.01769e-06	0.010729	1	0
ZNF416	55659	broad.mit.edu	37	19	58084091	58084091	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:58084091C>A	ENST00000196489.3	-	4	1403	c.1181G>T	c.(1180-1182)aGc>aTc	p.S394I		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AAGGCTGAAGCTTTGTCTGAA	0.453000													26	23					1.5548e-18	2.91461e-18	0.005443	1	0
OR2L13	284521	broad.mit.edu	37	1	248263312	248263312	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248263312G>T	ENST00000366478.2	+	3	972	c.635G>T	c.(634-636)gGc>gTc	p.G212V	OR2L13_ENST00000358120.2_Missense_Mutation_p.G212V	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.G212D(2)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CCTTTCATTGGCATCACTTCT	0.428000													11	60					3.07112e-06	4.01769e-06	0.010729	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	18023766	18023766	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:18023766G>T	ENST00000361221.3	+	29	3890	c.3731G>T	c.(3730-3732)gGg>gTg	p.G1244V	ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.G1205V|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.G947V|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.G1205V|ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.G1017V	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	1244					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		ATCTCCGGCGGGCAGGGCTAC	0.687000													29	20					6.38683e-12	1.05466e-11	0.008361	1	0
C4orf50	389197	broad.mit.edu	37	4	5961151	5961151	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:5961151A>T	ENST00000531445.1	-	7	2250	c.2204T>A	c.(2203-2205)aTt>aAt	p.I735N	C4orf50_ENST00000324058.5_Missense_Mutation_p.I261N			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	261										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						ATTGCTGCAAATGCTTTGTCT	0.488000													13	39					0	0	0.001855	0	0
SMARCA5	8467	broad.mit.edu	37	4	144442691	144442691	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:144442691A>T	ENST00000283131.3	+	3	824	c.362A>T	c.(361-363)aAa>aTa	p.K121I		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	121					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					TTGAAGATGAAACCAGGGCGC	0.383000													9	25					0	0	0.006214	0	0
USH2A	7399	broad.mit.edu	37	1	215847984	215847984	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:215847984G>T	ENST00000366943.2	-	63	13655	c.13269C>A	c.(13267-13269)gcC>gcA	p.A4423A	USH2A_ENST00000307340.3_Silent_p.A4423A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4423	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATTCGTGCAGGCTACAAGGG	0.507000										HNSCC(13;0.011)			12	36					5.50884e-06	7.0564e-06	0.001368	1	0
CPEB2	132864	broad.mit.edu	37	4	15009984	15009984	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:15009984C>A	ENST00000538197.1	+	3	1967	c.1967C>A	c.(1966-1968)cCa>cAa	p.P656Q	CPEB2_ENST00000541112.1_Missense_Mutation_p.P656Q|CPEB2_ENST00000382395.3_Intron|CPEB2_ENST00000382401.3_Intron|RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000442003.2_Intron|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000259997.5_Missense_Mutation_p.P219Q|CPEB2_ENST00000345451.3_Intron|CPEB2_ENST00000507071.1_Missense_Mutation_p.P219Q	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	219					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						TTGCAGTTGCCAGCTTGGGGC	0.443000													6	24					2.7689e-08	4.02685e-08	0.001984	1	0
BCLAF1	9774	broad.mit.edu	37	6	136589325	136589325	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:136589325C>A	ENST00000531224.1	-	10	2624	c.2372G>T	c.(2371-2373)gGa>gTa	p.G791V	BCLAF1_ENST00000527536.1_Missense_Mutation_p.G791V|BCLAF1_ENST00000392348.2_Missense_Mutation_p.G789V|BCLAF1_ENST00000530767.1_Missense_Mutation_p.G618V|BCLAF1_ENST00000031135.9_Missense_Mutation_p.G9V|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000353331.4_Missense_Mutation_p.G789V|BCLAF1_ENST00000527759.1_Missense_Mutation_p.G789V	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	791					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCGGCTAACTCCTGCAAAGCC	0.378000													9	99					1.3612e-06	1.8252e-06	0.003163	1	0
MCM6	4175	broad.mit.edu	37	2	136624258	136624258	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:136624258C>A	ENST00000264156.2	-	5	716	c.656G>T	c.(655-657)aGt>aTt	p.S219I		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	219					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GCGGGGGATACTCCCTCGAGG	0.448000													4	54					0.00024832	0.000288615	0.009096	1	0
PAX2	5076	broad.mit.edu	37	10	102509555	102509555	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:102509555C>T	ENST00000370296.2	+	2	646	c.96C>T	c.(94-96)ccC>ccT	p.P32P	PAX2_ENST00000556085.1_Silent_p.P31P|PAX2_ENST00000361791.3_Silent_p.P32P|PAX2_ENST00000553492.1_Intron|PAX2_ENST00000355243.3_Silent_p.P32P|PAX2_ENST00000428433.1_Silent_p.P32P			Q02962	PAX2_HUMAN	paired box 2	32	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		ACGGCCGGCCCCTACCCGACG	0.657000													12	33					0	0	0.001368	0	0
KIAA1109	84162	broad.mit.edu	37	4	123237904	123237904	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:123237904A>T	ENST00000264501.4	+	62	10930	c.10557A>T	c.(10555-10557)cgA>cgT	p.R3519R	KIAA1109_ENST00000455637.1_Silent_p.R3519R|KIAA1109_ENST00000388738.3_Silent_p.R3519R			Q2LD37	K1109_HUMAN	KIAA1109	3519					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CAGATTATCGAAGACAGGCAG	0.398000													20	39					0	0	0.002299	0	0
DDX5	1655	broad.mit.edu	37	17	62496295	62496295	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:62496295G>C	ENST00000225792.5	-	13	1992	c.1591C>G	c.(1591-1593)Cag>Gag	p.Q531E	DDX5_ENST00000578804.1_Missense_Mutation_p.Q531E|DDX5_ENST00000450599.2_Missense_Mutation_p.Q452E|DDX5_ENST00000580026.1_5'UTR	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	531					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			ACACCATTCTGAGTTTTTGCC	0.418000			T	ETV4	prostate								30	126					0	0	0.002836	0	0
AKAP9	10142	broad.mit.edu	37	7	91631164	91631164	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:91631164G>T	ENST00000359028.2	+	9	2194	c.1969G>T	c.(1969-1971)Gaa>Taa	p.E657*	AKAP9_ENST00000356239.3_Nonsense_Mutation_p.E645*|AKAP9_ENST00000358100.2_Nonsense_Mutation_p.E657*			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	657	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GGAAGATTTAGAAATTGAACA	0.333000			T	BRAF	papillary thyroid								19	25					5.03518e-11	8.08168e-11	0.007413	1	0
UNC45B	146862	broad.mit.edu	37	17	33497163	33497163	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:33497163G>T	ENST00000268876.5	+	12	1675	c.1578G>T	c.(1576-1578)cgG>cgT	p.R526R	UNC45B_ENST00000591048.1_Intron|UNC45B_ENST00000378449.1_Intron|UNC45B_ENST00000433649.1_Silent_p.R526R|UNC45B_ENST00000394570.2_Silent_p.R526R	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	526					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TAGACACTCGGACCCGACGCT	0.607000													22	89					6.44725e-10	9.94868e-10	0.002299	1	0
OR4D1	26689	broad.mit.edu	37	17	56233080	56233080	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:56233080G>T	ENST00000268912.5	+	1	587	c.566G>T	c.(565-567)tGc>tTc	p.C189F		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						AGACTTGCCTGCACTGATACC	0.488000													21	98					8.10497e-08	1.15622e-07	0.010504	1	0
LAMA2	3908	broad.mit.edu	37	6	129634139	129634139	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:129634139G>T	ENST00000421865.2	+	23	3357	c.3308G>T	c.(3307-3309)tGc>tTc	p.C1103F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1103	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TACCCTCGCTGCAATCTCTGT	0.468000													15	54					1.3612e-06	1.8252e-06	0.003163	1	0
GDF2	2658	broad.mit.edu	37	10	48414232	48414232	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:48414232C>T	ENST00000249598.1	-	2	795	c.636G>A	c.(634-636)aaG>aaA	p.K212K		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	212					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GGACCCAGCGCTTCACGGCGC	0.587000													12	59					0	0	0.001368	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033530	82033530	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:82033530G>A	ENST00000328945.5	-	3	495	c.368C>T	c.(367-369)aCt>aTt	p.T123I	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	123					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						GACATTGAAAGTGCTGGTGTA	0.488000													19	59					0	0	0.006122	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490554	141490554	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:141490554G>T	ENST00000247883.4	+	1	538	c.393G>T	c.(391-393)ctG>ctT	p.L131L		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	131					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					GGTGCCTTCTGGGCTACTTTA	0.463000													18	44					3.51602e-12	5.84529e-12	0.008871	1	0
SSPO	23145	broad.mit.edu	37	7	149490413	149490413	+	RNA	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:149490413C>A	ENST00000378016.2	+	0	5889							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGACGGAGCCCTGTGAGGGGT	0.642000													11	43					9.05144e-12	1.48326e-11	0.001855	1	0
ACSM5	54988	broad.mit.edu	37	16	20451195	20451195	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:20451195A>T	ENST00000331849.4	+	13	1757	c.1610A>T	c.(1609-1611)cAg>cTg	p.Q537L		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	537					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CGGGAACTCCAGGAGCATGTG	0.493000													18	102					0	0	0.004990	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644564	74644564	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:74644564G>T	ENST00000541184.1	-	7	1109	c.632C>A	c.(631-633)gCc>gAc	p.A211D	ZDHHC15_ENST00000373361.3_Missense_Mutation_p.P180T|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.A220D	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	220						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						AAACATGCAGGCCACAAAGAG	0.383000													4	4					0.00909568	0.00969341	0.009096	1	0
RRM1	6240	broad.mit.edu	37	11	4133143	4133143	+	Silent	SNP	A	A	T	rs12807843		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:4133143A>T	ENST00000300738.5	+	7	705	c.501A>T	c.(499-501)ccA>ccT	p.P167P	RRM1_ENST00000423050.2_Silent_p.P70P	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	167					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	CTGAAAGACCACAACATATGT	0.373000													3	13					0	0	0.009096	0	0
CSMD3	114788	broad.mit.edu	37	8	113569024	113569024	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:113569024C>A	ENST00000297405.5	-	25	4446	c.4202G>T	c.(4201-4203)aGg>aTg	p.R1401M	CSMD3_ENST00000455883.2_Missense_Mutation_p.R1297M|CSMD3_ENST00000343508.3_Missense_Mutation_p.R1361M|CSMD3_ENST00000352409.3_Missense_Mutation_p.R1401M	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1401	Sushi 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTCCCATGCCCTTCTCTCCCC	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	27					2.89027e-11	4.66514e-11	0.002299	1	0
APOBEC1	339	broad.mit.edu	37	12	7805356	7805356	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:7805356G>A	ENST00000229304.4	-	3	140	c.120C>T	c.(118-120)taC>taT	p.Y40Y		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	40					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						ACTTGATTTCGTAGAGCAGAC	0.448000													10	39					0	0	0.008291	0	0
NFRKB	4798	broad.mit.edu	37	11	129753093	129753093	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:129753093C>T	ENST00000446488.3	-	8	928	c.825G>A	c.(823-825)ccG>ccA	p.P275P	NFRKB_ENST00000524794.1_Silent_p.P300P|NFRKB_ENST00000524746.1_Silent_p.P275P|NFRKB_ENST00000304521.5_Silent_p.P275P	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	275					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TCAAAAGGTCCGGGTGATCCT	0.468000													20	46					0	0	0.002780	0	0
CEP120	153241	broad.mit.edu	37	5	122717864	122717864	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:122717864C>A	ENST00000306467.5	-	14	2348	c.2044G>T	c.(2044-2046)Gct>Tct	p.A682S	CEP120_ENST00000306481.6_Missense_Mutation_p.A656S|CEP120_ENST00000328236.5_Missense_Mutation_p.A682S			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	682						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TCTGCAAGAGCCTGCATATGA	0.368000													13	24					8.60227e-14	1.49216e-13	0.004007	1	0
SARS2	54938	broad.mit.edu	37	19	39408393	39408393	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:39408393C>A	ENST00000221431.6	-	12	1290	c.1131G>T	c.(1129-1131)gaG>gaT	p.E377D	SARS2_ENST00000594171.1_Missense_Mutation_p.E187D|SARS2_ENST00000430193.3_Missense_Mutation_p.E377D|SARS2_ENST00000448145.2_Missense_Mutation_p.E377D|SARS2_ENST00000600042.1_Missense_Mutation_p.E379D|SARS2_ENST00000598831.1_Missense_Mutation_p.E25D|CTC-360G5.8_ENST00000599996.1_Missense_Mutation_p.D447Y	NM_017827.3	NP_060297.1	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2, mitochondrial	377					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTGTCAAGATCTCCATCTGAA	0.637000													16	32					0.000422831	0.000486837	0.004007	1	0
HECW2	57520	broad.mit.edu	37	2	197183691	197183691	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:197183691A>T	ENST00000260983.2	-	9	2105	c.1923T>A	c.(1921-1923)gcT>gcA	p.A641A	HECW2_ENST00000409111.1_Silent_p.A285A	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	641					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AGGAGCTGTCAGCGCATTCCA	0.582000													6	29					0	0	0.001168	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092431	30092431	+	RNA	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:30092431C>G	ENST00000567636.1	+	0	806					NR_003558.1																						TGGTCCACCCCCTCCTCAAGT	0.537000													13	62					0	0	0.001368	0	0
SYTL1	84958	broad.mit.edu	37	1	27677381	27677381	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:27677381G>T	ENST00000543823.1	+	10	1564	c.1102G>T	c.(1102-1104)Gaa>Taa	p.E368*	SYTL1_ENST00000318074.5_Nonsense_Mutation_p.E356*|SYTL1_ENST00000490170.1_3'UTR			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	368	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCGAAGTTGAAGTGCCCCT	0.692000													11	40					3.86212e-05	4.72862e-05	0.008291	1	0
TRIM24	8805	broad.mit.edu	37	7	138239468	138239468	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:138239468G>T	ENST00000343526.4	+	9	1502	c.1287G>T	c.(1285-1287)gaG>gaT	p.E429D	TRIM24_ENST00000497516.1_3'UTR|TRIM24_ENST00000415680.2_Missense_Mutation_p.E429D			O15164	TIF1A_HUMAN	tripartite motif containing 24	429					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						AGGATAAAGAGAGCCAGCCAC	0.373000													40	60					1.96642e-18	3.67022e-18	0.006999	1	0
SEC63	11231	broad.mit.edu	37	6	108214792	108214792	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:108214792G>C	ENST00000369002.4	-	16	1747	c.1568C>G	c.(1567-1569)aCt>aGt	p.T523S		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	523	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TGATTTAGCAGTTTTCTTGGG	0.378000													16	106					0	0	0.003163	0	0
MGA	23269	broad.mit.edu	37	15	41989078	41989078	+	Nonsense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:41989078A>T	ENST00000219905.7	+	3	2051	c.1870A>T	c.(1870-1872)Aag>Tag	p.K624*	MGA_ENST00000389936.4_Nonsense_Mutation_p.K624*|MGA_ENST00000545763.1_Nonsense_Mutation_p.K624*|MGA_ENST00000566586.1_Nonsense_Mutation_p.K624*|MGA_ENST00000570161.1_Nonsense_Mutation_p.K624*	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	624						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAAACTCTGTAAGGCAGGACG	0.443000													6	4					0	0	0.001168	0	0
MTMR12	54545	broad.mit.edu	37	5	32229899	32229899	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:32229899G>A	ENST00000382142.3	-	16	2399	c.2229C>T	c.(2227-2229)gaC>gaT	p.D743D	MTMR12_ENST00000280285.5_Silent_p.D689D|MTMR12_ENST00000264934.5_Silent_p.D633D	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	743						cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CATCCCCTAGGTCCACGAACT	0.507000													18	87					0	0	0.006122	0	0
IQSEC1	9922	broad.mit.edu	37	3	12950017	12950017	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:12950017C>G	ENST00000273221.4	-	12	2845	c.2629G>C	c.(2629-2631)Gag>Cag	p.E877Q		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	877					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TTCTGCTTCTCGAGCTCCGCT	0.627000													41	64					0	0	0.009718	0	0
SCML2	10389	broad.mit.edu	37	X	18276333	18276333	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:18276333G>A	ENST00000251900.4	-	10	1263	c.1104C>T	c.(1102-1104)ggC>ggT	p.G368G	SCML2_ENST00000398048.3_Silent_p.G104G	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	368					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					CCAGATGAGGGCCAAAGTTTC	0.463000													16	53					0	0	0.003163	0	0
RTTN	25914	broad.mit.edu	37	18	67863821	67863821	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:67863821C>A	ENST00000255674.6	-	7	1043	c.757G>T	c.(757-759)Gtg>Ttg	p.V253L	RTTN_ENST00000437017.1_Missense_Mutation_p.V253L|RTTN_ENST00000454359.1_Missense_Mutation_p.V253L	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	253							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				AGGCAGGACACCGACTGTAAT	0.413000													24	37					2.21704e-12	3.71813e-12	0.002780	1	0
GJA5	2702	broad.mit.edu	37	1	147230755	147230755	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:147230755C>T	ENST00000271348.2	-	2	753	c.592G>A	c.(592-594)Gta>Ata	p.V198I	GJA5_ENST00000369237.1_Missense_Mutation_p.V198I	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	198					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GGCCGGGATACGTAACAGTTG	0.567000													10	34					0	0	0.006214	0	0
FYN	2534	broad.mit.edu	37	6	111983136	111983136	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:111983136C>A	ENST00000354650.3	-	14	2026	c.1420G>T	c.(1420-1422)Gag>Tag	p.E474*	FYN_ENST00000368678.4_Nonsense_Mutation_p.E471*|FYN_ENST00000229471.4_Nonsense_Mutation_p.E419*|FYN_ENST00000229470.5_Nonsense_Mutation_p.E422*|FYN_ENST00000538466.1_Nonsense_Mutation_p.E471*|FYN_ENST00000368667.2_Nonsense_Mutation_p.E474*|FYN_ENST00000368682.3_Nonsense_Mutation_p.E471*|FYN_ENST00000356013.2_Nonsense_Mutation_p.E419*	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	474	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCCAGCACCTCCCGGTTGTTC	0.607000													13	75					0.00136819	0.00152426	0.001368	1	0
ABHD4	63874	broad.mit.edu	37	14	23078735	23078735	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:23078735C>A	ENST00000428304.2	+	6	928	c.858C>A	c.(856-858)atC>atA	p.I286I		NM_022060.2	NP_071343.2	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	286					lipid catabolic process		hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(3)|prostate(1)	14	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		TCACTATGATCTACGGGTCCG	0.517000													6	46					8.12818e-05	9.70302e-05	0.001984	1	0
TP63	8626	broad.mit.edu	37	3	189455623	189455623	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:189455623G>C	ENST00000264731.3	+	2	246	c.157G>C	c.(157-159)Gag>Cag	p.E53Q	TP63_ENST00000392460.3_Missense_Mutation_p.E53Q|TP63_ENST00000320472.5_Missense_Mutation_p.E53Q|TP63_ENST00000440651.2_Missense_Mutation_p.E53Q|TP63_ENST00000418709.2_Missense_Mutation_p.E53Q|TP63_ENST00000382063.4_Missense_Mutation_p.E53Q	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	53	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCTCAGTCCAGAGGTTTTCCA	0.388000										HNSCC(45;0.13)			9	30					0	0	0.004482	0	0
HGF	3082	broad.mit.edu	37	7	81388113	81388113	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:81388113C>A	ENST00000222390.5	-	3	488	c.262G>T	c.(262-264)Gtt>Ttt	p.V88F	HGF_ENST00000444829.2_Missense_Mutation_p.V88F|HGF_ENST00000453411.1_Missense_Mutation_p.V88F|HGF_ENST00000453018.1_5'UTR|HGF_ENST00000457544.2_Missense_Mutation_p.V88F|HGF_ENST00000354224.6_Missense_Mutation_p.V88F|HGF_ENST00000423064.2_Missense_Mutation_p.V88F	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	88	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTATCAAAAACAAAAGCCCTG	0.338000													22	32					9.62636e-23	1.86348e-22	0.002299	1	0
OR10A4	283297	broad.mit.edu	37	11	6898042	6898042	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:6898042C>T	ENST00000379829.2	+	1	187	c.164C>T	c.(163-165)gCa>gTa	p.A55V		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCTGACTCTGCACTACAAAGT	0.443000													14	53					0	0	0.001855	0	0
NRG3	10718	broad.mit.edu	37	10	84744865	84744865	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:84744865G>A	ENST00000372142.2	+	11	1278	c.1004G>A	c.(1003-1005)aGt>aAt	p.S335N	NRG3_ENST00000372141.2_Missense_Mutation_p.S532N|NRG3_ENST00000545131.1_Missense_Mutation_p.S182N|NRG3_ENST00000556918.1_Missense_Mutation_p.S362N|NRG3_ENST00000404547.1_Missense_Mutation_p.S556N|NRG3_ENST00000537893.1_Missense_Mutation_p.S182N|NRG3_ENST00000404576.2_Missense_Mutation_p.S336N	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	556					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TATTCATCCAGTGGTTTAAAA	0.403000													34	183					0	0	0.010818	0	0
SPERT	220082	broad.mit.edu	37	13	46287685	46287685	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:46287685G>A	ENST00000378966.3	+	2	833	c.417G>A	c.(415-417)ctG>ctA	p.L139L	SPERT_ENST00000310521.1_Silent_p.L175L			Q8NA61	SPERT_HUMAN	spermatid associated	175						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ACAAGTCTCTGCGGGAGGAGA	0.602000													8	56					0	0	0.004482	0	0
DNAH1	25981	broad.mit.edu	37	3	52412653	52412653	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:52412653C>T	ENST00000420323.2	+	47	7495	c.7234C>T	c.(7234-7236)Ctt>Ttt	p.L2412F		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2412	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACGGAGCCCCTTGTGGAAGC	0.617000													31	93					0	0	0.008361	0	0
IAPP	3375	broad.mit.edu	37	12	21531345	21531345	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:21531345T>G	ENST00000240652.3	+	3	391	c.255T>G	c.(253-255)aaT>aaG	p.N85K	SLCO1A2_ENST00000537524.1_Intron|IAPP_ENST00000542023.1_3'UTR|SLCO1A2_ENST00000307378.6_Intron|IAPP_ENST00000539393.1_Missense_Mutation_p.N85K|SLCO1A2_ENST00000473830.1_Intron	NM_000415.2	NP_000406.1	P10997	IAPP_HUMAN	islet amyloid polypeptide	85					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity			lung(3)	3					Perindopril(DB00790)	AGCCACTGAATTACTTGCCCC	0.398000													15	34					0	0	0.002450	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041051	64041051	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:64041051G>A	ENST00000324472.4	-	5	866	c.683C>T	c.(682-684)cCt>cTt	p.P228L	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	228					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCATTAAGAGGTTCTATTCT	0.323000													10	33					0	0	0.001855	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19687566	19687566	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr21:19687566G>A	ENST00000284885.3	-	17	1962	c.1929C>T	c.(1927-1929)tgC>tgT	p.C643C		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	643	LDL-receptor class A 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						GGTCTGCCTTGCATGGCTCTA	0.413000													6	27					0	0	0.001168	0	0
EPHA4	2043	broad.mit.edu	37	2	222301814	222301814	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:222301814G>T	ENST00000281821.2	-	12	2144	c.2103C>A	c.(2101-2103)taC>taA	p.Y701*	EPHA4_ENST00000392071.4_Nonsense_Mutation_p.Y650*|EPHA4_ENST00000409938.1_Nonsense_Mutation_p.Y701*|EPHA4_ENST00000409854.1_Nonsense_Mutation_p.Y701*	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	701	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CATTCTCCATGTACTCTGTTA	0.388000													10	42					1.58986e-06	2.11859e-06	0.008291	1	0
PAPPA2	60676	broad.mit.edu	37	1	176708847	176708847	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:176708847C>A	ENST00000367662.3	+	13	5048	c.3884C>A	c.(3883-3885)cCg>cAg	p.P1295Q		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1295					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CATCAGCAGCCGACAGTGACT	0.483000													11	27					1.08611e-07	1.52534e-07	0.010729	1	0
FLNC	2318	broad.mit.edu	37	7	128490526	128490526	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:128490526G>T	ENST00000325888.8	+	32	5648	c.5387G>T	c.(5386-5388)gGg>gTg	p.G1796V	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.G1763V	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1796					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GTGCAGAAAGGGGAGCTCACA	0.597000													40	73					1.07121e-22	2.06667e-22	0.006999	1	0
JPH3	57338	broad.mit.edu	37	16	87678337	87678337	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:87678337G>A	ENST00000284262.2	+	2	1098	c.856G>A	c.(856-858)Gag>Aag	p.E286K		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	286					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CACCACCACCGAGACCTACGT	0.672000													16	45					0	0	0.004990	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255361	15255361	+	Silent	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:15255361A>T	ENST00000378116.4	-	8	2232	c.2226T>A	c.(2224-2226)tcT>tcA	p.S742S		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	742						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TATCTACGCCAGAGTCCAAAC	0.507000													11	50					0	0	0.008291	0	0
KIF4B	285643	broad.mit.edu	37	5	154394958	154394958	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:154394958T>A	ENST00000435029.4	+	1	1699	c.1539T>A	c.(1537-1539)acT>acA	p.T513T		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	513					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTTTTACCACTCAGCATGCTC	0.498000													11	33					0	0	0.008291	0	0
MRVI1	10335	broad.mit.edu	37	11	10648107	10648107	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:10648107G>T	ENST00000547195.1	-	8	1001	c.501C>A	c.(499-501)gaC>gaA	p.D167E	MRVI1_ENST00000552103.1_Missense_Mutation_p.D167E|MRVI1_ENST00000527509.2_Missense_Mutation_p.D167E|MRVI1_ENST00000436272.1_Missense_Mutation_p.D231E|MRVI1_ENST00000423302.2_Missense_Mutation_p.D258E|MRVI1_ENST00000545852.1_5'UTR|MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000534266.2_5'UTR|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000541483.1_Intron|MRVI1_ENST00000421747.1_Missense_Mutation_p.D249E|MRVI1_ENST00000531107.1_Missense_Mutation_p.D250E	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	231	Interaction with PRKG1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TCTGCTTCCTGTCAGCTAGCC	0.532000													3	13					6.4e-05	7.73298e-05	0.004672	1	0
TENM2	57451	broad.mit.edu	37	5	167674058	167674058	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:167674058C>A	ENST00000519204.1	+	26	5869	c.5751C>A	c.(5749-5751)gtC>gtA	p.V1917V	TENM2_ENST00000545108.1_Silent_p.V2037V|TENM2_ENST00000403607.2_Silent_p.V1862V|TENM2_ENST00000518659.1_Silent_p.V2038V|TENM2_ENST00000520394.1_Silent_p.V1799V					teneurin transmembrane protein 2																		GTACCGCCGTCACCTTCGGGT	0.542000													17	33					9.16793e-09	1.35625e-08	0.004990	1	0
OR5B3	441608	broad.mit.edu	37	11	58170407	58170407	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:58170407C>A	ENST00000309403.2	-	1	475	c.476G>T	c.(475-477)gGg>gTg	p.G159V		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AAATGTGTCCCCAGTGTGGAT	0.453000													19	50					0.00152264	0.00169522	0.010504	1	0
WBSCR17	64409	broad.mit.edu	37	7	71135054	71135054	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:71135054C>A	ENST00000333538.5	+	8	1998	c.1364C>A	c.(1363-1365)cCa>cAa	p.P455Q	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	455						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATGTTTACCCAGAAATGAGA	0.428000													58	128					6.60958e-23	1.28673e-22	0.003610	1	0
CDH10	1008	broad.mit.edu	37	5	24537582	24537582	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:24537582C>A	ENST00000264463.4	-	3	940	c.433G>T	c.(433-435)Gag>Tag	p.E145*		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	145	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E145K(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATCACAAACTCTGACTCTGGC	0.423000										HNSCC(23;0.051)			24	181					7.92952e-12	1.30065e-11	0.003954	1	0
VCP	7415	broad.mit.edu	37	9	35065277	35065277	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:35065277G>A	ENST00000358901.6	-	5	1442	c.547C>T	c.(547-549)Cac>Tac	p.H183Y		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	183					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCTTCGCAGTGGATCACTGTG	0.473000													19	42					0	0	0.007413	0	0
PRDM10	56980	broad.mit.edu	37	11	129793258	129793258	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:129793258T>C	ENST00000358825.5	-	14	2162	c.1931A>G	c.(1930-1932)tAc>tGc	p.Y644C	PRDM10_ENST00000526082.1_Missense_Mutation_p.Y558C|PRDM10_ENST00000528746.1_Missense_Mutation_p.Y614C|PRDM10_ENST00000304538.6_Missense_Mutation_p.Y554C|PRDM10_ENST00000360871.3_Missense_Mutation_p.Y640C|PRDM10_ENST00000423662.2_Missense_Mutation_p.Y558C	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TGTGCACTGGTAGATCTTTTC	0.512000											OREG0021513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					0	0	0.009096	0	0
SLC39A12	221074	broad.mit.edu	37	10	18280168	18280168	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:18280168G>T	ENST00000377369.2	+	8	1631	c.1358G>T	c.(1357-1359)gGa>gTa	p.G453V	SLC39A12_ENST00000377374.4_Missense_Mutation_p.G453V|SLC39A12_ENST00000377371.3_Missense_Mutation_p.G453V|SLC39A12_ENST00000539911.1_Missense_Mutation_p.G319V	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	453					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						GGATTAATTGGAGGCATCCAT	0.343000													15	45					0.000219431	0.000256775	0.002450	1	0
TFAP2B	7021	broad.mit.edu	37	6	50807921	50807921	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:50807921T>G	ENST00000263046.4	+	7	1186	c.1020T>G	c.(1018-1020)ttT>ttG	p.F340L	TFAP2B_ENST00000393655.3_Missense_Mutation_p.F331L			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	331					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					AAACGGAGTTTCCCGCCAAAG	0.478000													31	122					0	0	0.009535	0	0
PCLO	27445	broad.mit.edu	37	7	82545187	82545187	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:82545187C>G	ENST00000423517.2	-	7	12452	c.12115G>C	c.(12115-12117)Gat>Cat	p.D4039H	PCLO_ENST00000333891.8_Missense_Mutation_p.D4039H|PCLO_ENST00000437081.1_Missense_Mutation_p.D759H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3970					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTATGGTGATCAATATCTGCA	0.403000													31	61					0	0	0.007291	0	0
UTS2R	2837	broad.mit.edu	37	17	80332573	80332573	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:80332573G>T	ENST00000313135.2	+	1	421	c.373G>T	c.(373-375)Gtg>Ttg	p.V125L		NM_018949.1	NP_061822.1	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	125						integral to membrane|plasma membrane				breast(1)|endometrium(4)|kidney(1)|lung(2)	8	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			GGGCTGCCGCGTGCTCTTCGG	0.657000													14	33					4.3838e-07	5.98551e-07	0.001855	1	0
OR4S2	219431	broad.mit.edu	37	11	55418948	55418948	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55418948C>A	ENST00000312422.2	+	1	569	c.569C>A	c.(568-570)aCa>aAa	p.T190K		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TGCACAGAAACATACATTGTT	0.448000													32	140					6.53348e-20	1.24513e-19	0.003755	1	0
CFHR3	10878	broad.mit.edu	37	1	196762605	196762605	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:196762605T>A	ENST00000367425.4	+	6	1047	c.955T>A	c.(955-957)Tgt>Agt	p.C319S	CFHR3_ENST00000391985.3_Missense_Mutation_p.C258S	NM_021023.5	NP_066303.2			complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TCAAGCAGTGTGTCGGGAAGG	0.373000													14	66					0	0	0.003163	0	0
ZNF213	7760	broad.mit.edu	37	16	3191229	3191229	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:3191229C>T	ENST00000396878.3	+	6	1736	c.1261C>T	c.(1261-1263)Cgt>Tgt	p.R421C	ZNF213_ENST00000416391.2_Missense_Mutation_p.R263C|ZNF213_ENST00000574902.1_Missense_Mutation_p.R421C|ZNF213_ENST00000576416.1_Missense_Mutation_p.R421C	NM_001134655.1|NM_004220.2	NP_001128127.1|NP_004211.1	O14771	ZN213_HUMAN	zinc finger protein 213	421					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	16						GGACCATCGGCGTGTGCACAC	0.657000													7	26					0	0	0.003080	0	0
OR4S2	219431	broad.mit.edu	37	11	55419038	55419038	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55419038T>A	ENST00000312422.2	+	1	659	c.659T>A	c.(658-660)cTa>cAa	p.L220Q		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				AGCATCATCCTAGTTTCCCTG	0.493000													20	92					0	0	0.007413	0	0
AKAP6	9472	broad.mit.edu	37	14	33291653	33291653	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:33291653A>G	ENST00000280979.4	+	13	4804	c.4634A>G	c.(4633-4635)aAt>aGt	p.N1545S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1545					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAAAGTGGCAATATAGAAAAG	0.398000													11	58					0	0	0.010729	0	0
TRPM3	80036	broad.mit.edu	37	9	73255569	73255569	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:73255569A>T	ENST00000377110.2	-	10	1596	c.1353T>A	c.(1351-1353)aaT>aaA	p.N451K	TRPM3_ENST00000396280.5_Missense_Mutation_p.N298K|TRPM3_ENST00000396285.1_Missense_Mutation_p.N298K|TRPM3_ENST00000396292.4_Missense_Mutation_p.N323K|TRPM3_ENST00000377111.2_Missense_Mutation_p.N451K|TRPM3_ENST00000377105.1_Missense_Mutation_p.N298K|TRPM3_ENST00000377106.1_Missense_Mutation_p.N323K|TRPM3_ENST00000408909.2_Missense_Mutation_p.N298K|TRPM3_ENST00000423814.3_Missense_Mutation_p.N478K|TRPM3_ENST00000357533.2_Missense_Mutation_p.N453K|TRPM3_ENST00000360823.2_Missense_Mutation_p.N323K|TRPM3_ENST00000358082.3_Missense_Mutation_p.N323K	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	476						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GGGCCGAGGCATTGGCTCCTG	0.522000											OREG0019249	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	0.004672	0	0
SRFBP1	153443	broad.mit.edu	37	5	121356024	121356024	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:121356024G>T	ENST00000339397.4	+	6	666	c.594G>T	c.(592-594)gtG>gtT	p.V198V		NM_152546.2	NP_689759.2	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|skin(1)	15		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		CTAAAGCAGTGACTATTGCAA	0.383000													4	24					0.00024832	0.000288615	0.009096	1	0
RPRD1A	55197	broad.mit.edu	37	18	33610792	33610792	+	Silent	SNP	T	T	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:33610792T>G	ENST00000399022.4	-	4	636	c.465A>C	c.(463-465)ggA>ggC	p.G155G	RPRD1A_ENST00000588737.1_Silent_p.G119G|RPRD1A_ENST00000357384.4_Silent_p.G155G|RPRD1A_ENST00000337059.5_Silent_p.G119G|RPRD1A_ENST00000319040.6_Silent_p.G155G|RPRD1A_ENST00000590898.1_Silent_p.G119G	NM_018170.3	NP_060640.2	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing 1A	155										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(2)	12						CACTTGGAGATCCCAGAGAGG	0.358000													3	20					0	0	0.004672	0	0
KLHL4	56062	broad.mit.edu	37	X	86880684	86880684	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:86880684G>A	ENST00000373119.4	+	6	1357	c.1212G>A	c.(1210-1212)atG>atA	p.M404I	KLHL4_ENST00000373114.4_Missense_Mutation_p.M404I	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	404						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TGGAAGCTATGAAGTATCATC	0.443000													7	28					0	0	0.003080	0	0
CASC3	22794	broad.mit.edu	37	17	38319962	38319962	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:38319962G>T	ENST00000264645.7	+	7	1240	c.1014G>T	c.(1012-1014)cgG>cgT	p.R338R		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	338					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						ATGGTGGCCGGTCTGGTGAGA	0.552000													35	190					4.3181e-19	8.15694e-19	0.002836	1	0
RNPS1	10921	broad.mit.edu	37	16	2314333	2314333	+	Splice_Site	SNP	C	C	A	rs112148202		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:2314333C>A	ENST00000565678.1	-	3	617		c.e3-1		RNPS1_ENST00000397086.2_Splice_Site|RNPS1_ENST00000320225.5_Splice_Site|RNPS1_ENST00000561718.1_Splice_Site|RNPS1_ENST00000567147.1_Splice_Site|RNPS1_ENST00000568631.1_Splice_Site|RNPS1_ENST00000301730.8_Splice_Site|RNPS1_ENST00000566458.1_Splice_Site|RNPS1_ENST00000569598.2_Intron			Q15287	RNPS1_HUMAN	RNA binding protein S1, serine-rich domain						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|urinary_tract(1)	9						TGAAGGAGCCCTGGATGGTGA	0.547000													38	39					1.07121e-22	2.06667e-22	0.006999	1	0
SPRY2	10253	broad.mit.edu	37	13	80911327	80911327	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:80911327C>A	ENST00000377102.1	-	2	1491	c.514G>T	c.(514-516)Ggc>Tgc	p.G172C	SPRY2_ENST00000540649.1_Missense_Mutation_p.G172C|SPRY2_ENST00000377104.3_Missense_Mutation_p.G172C			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	172					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		GCGTGCAGGCCCAAATCTTCC	0.552000													7	30					1.06961e-07	1.51455e-07	0.003080	1	0
RYR2	6262	broad.mit.edu	37	1	237837423	237837423	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:237837423C>A	ENST00000366574.2	+	59	8935	c.8618C>A	c.(8617-8619)cCc>cAc	p.P2873H	RYR2_ENST00000542537.1_Missense_Mutation_p.P2857H|RYR2_ENST00000360064.6_Missense_Mutation_p.P2871H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2873	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGCTGGTGCCCTATGATACA	0.413000													18	74					2.94398e-08	4.27786e-08	0.007413	1	0
ATRX	546	broad.mit.edu	37	X	76939494	76939494	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:76939494T>A	ENST00000373344.5	-	9	1468	c.1254A>T	c.(1252-1254)cgA>cgT	p.R418R	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Silent_p.R380R	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	418					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CATCCATCGCTCGAAACTCGG	0.373000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						59	87					0	0	0.003610	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597469	136597469	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:136597469T>A	ENST00000531224.1	-	5	1446	c.1194A>T	c.(1192-1194)gaA>gaT	p.E398D	BCLAF1_ENST00000527536.1_Missense_Mutation_p.E398D|BCLAF1_ENST00000392348.2_Missense_Mutation_p.E396D|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E396D|BCLAF1_ENST00000527759.1_Missense_Mutation_p.E396D	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	398					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGTCATCCCCTTCTGAATCAT	0.443000													37	230					0	0	0.007835	0	0
FSTL5	56884	broad.mit.edu	37	4	162307033	162307033	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:162307033C>A	ENST00000306100.5	-	16	2846	c.2410G>T	c.(2410-2412)Ggc>Tgc	p.G804C	FSTL5_ENST00000379164.4_Missense_Mutation_p.G803C|RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000536695.1_Missense_Mutation_p.G803C|FSTL5_ENST00000427802.2_Missense_Mutation_p.G794C	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	804						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCAAACAAGCCACTGTCCTGG	0.443000													14	72					9.31168e-06	1.18569e-05	0.001855	1	0
TEX35	84066	broad.mit.edu	37	1	178485794	178485794	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:178485794T>A	ENST00000367641.3	+	5	320	c.261T>A	c.(259-261)ttT>ttA	p.F87L	TEX35_ENST00000367642.3_Intron|TEX35_ENST00000367639.1_Missense_Mutation_p.F95L|TEX35_ENST00000319416.2_Missense_Mutation_p.F87L|TEX35_ENST00000258298.2_Missense_Mutation_p.F11L|TEX35_ENST00000367643.3_Missense_Mutation_p.F87L					testis expressed 35																		TTCACGAATTTGTGGAAATTA	0.438000													4	15					0	0	0.000602	0	0
RNA5-8SP2	100873571	broad.mit.edu	37	16	33965520	33965520	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:33965520C>T	ENST00000363564.1	+	0	95																											TGATCATCGACACTTCGAACG	0.557000													3	19					0	0	0.001168	0	0
TMCO3	55002	broad.mit.edu	37	13	114175005	114175005	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:114175005G>A	ENST00000434316.2	+	8	1659	c.1300G>A	c.(1300-1302)Gtc>Atc	p.V434I	TMCO3_ENST00000375391.1_Intron|TMCO3_ENST00000474393.1_3'UTR	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	434						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CTTCATGGCCGTCATGCCGAC	0.512000													3	33					0	0	0.004672	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858450	43858450	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:43858450C>T	ENST00000389420.3	-	10	1452	c.1453G>A	c.(1453-1455)Gga>Aga	p.G485R	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G485R	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	485	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGCTTGTTTCCATCATATCGT	0.398000													10	55					0	0	0.006214	0	0
WIPF3	644150	broad.mit.edu	37	7	29915475	29915475	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:29915475G>A	ENST00000409290.1	+	2	120	c.120G>A	c.(118-120)agG>agA	p.R40R	WIPF3_ENST00000242140.5_Silent_p.R40R|WIPF3_ENST00000409123.1_Silent_p.R40R	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	40										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						GCTTGCGAAGGGCAGATCCGA	0.527000													5	42					0	0	0.000602	0	0
GABRP	2568	broad.mit.edu	37	5	170235603	170235603	+	Splice_Site	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:170235603G>A	ENST00000518525.1	+	9	1143		c.e9-1		GABRP_ENST00000519598.1_Splice_Site|GABRP_ENST00000519385.1_Splice_Site|GABRP_ENST00000265294.4_Splice_Site			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi							cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TACCCTTTCAGGAAATTACAC	0.403000													8	28					0	0	0.004482	0	0
GYPA	2993	broad.mit.edu	37	4	145039884	145039884	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:145039884T>A	ENST00000360771.4	-	4	369	c.254A>T	c.(253-255)cAt>cTt	p.H85L	GYPA_ENST00000512064.1_Intron|GYPA_ENST00000504786.1_Missense_Mutation_p.H53L|GYPA_ENST00000512789.1_Missense_Mutation_p.H20L|GYPA_ENST00000324022.10_Missense_Mutation_p.H52L|GYPA_ENST00000535709.1_Missense_Mutation_p.H59L|GYPA_ENST00000503627.1_Intron|RP11-673E1.4_ENST00000506982.1_RNA|GYPB_ENST00000283126.7_Intron	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	85					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					AGAGAAATGATGGGCAAGTTG	0.313000													11	48					0	0	0.001855	0	0
MANEA	79694	broad.mit.edu	37	6	96054232	96054232	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:96054232G>T	ENST00000358812.4	+	5	1474	c.1340G>T	c.(1339-1341)aGt>aTt	p.S447I		NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	447	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		GAAAAATACAGTAAGGAAAGA	0.358000													7	17					0.00307968	0.00338706	0.003080	1	0
C1orf95	375057	broad.mit.edu	37	1	226784531	226784531	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:226784531G>T	ENST00000366788.3	+	2	336	c.231G>T	c.(229-231)ctG>ctT	p.L77L	C1orf95_ENST00000366789.4_Silent_p.L77L	NM_001003665.3	NP_001003665.1	Q69YW2	CA095_HUMAN	chromosome 1 open reading frame 95	77						integral to membrane				large_intestine(1)|lung(4)|ovary(3)	8	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		TCACTGTGCTGTGCGGGGCCC	0.612000													17	87					1.56452e-12	2.63927e-12	0.007413	1	0
SWT1	54823	broad.mit.edu	37	1	185153929	185153929	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:185153929G>T	ENST00000367500.4	+	9	1460	c.1295G>T	c.(1294-1296)cGt>cTt	p.R432L	SWT1_ENST00000367501.3_Missense_Mutation_p.R432L	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	432	PINc.							p.R432H(1)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						GAGCTAGATCGTATGAAGGAA	0.343000													8	56					5.4927e-09	8.18194e-09	0.004482	1	0
FAM171B	165215	broad.mit.edu	37	2	187615934	187615934	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:187615934G>C	ENST00000304698.5	+	5	1001	c.798G>C	c.(796-798)aaG>aaC	p.K266N		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	266				K -> R (in Ref. 4; AAL57220).		integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AAGAACTAAAGGTCAATGGCT	0.353000													10	71					0	0	0.006214	0	0
BCAS1	8537	broad.mit.edu	37	20	52645453	52645453	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:52645453C>A	ENST00000395961.3	-	4	367	c.201G>T	c.(199-201)acG>acT	p.T67T	BCAS1_ENST00000371440.3_Silent_p.T67T|BCAS1_ENST00000371435.2_Silent_p.T67T|BCAS1_ENST00000411563.1_5'UTR	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	67						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CACTTATCTCCGTTGTCTCGG	0.483000													8	31					0.000157383	0.000184418	0.003080	1	0
TP53BP2	7159	broad.mit.edu	37	1	223984286	223984286	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:223984286C>G	ENST00000391878.2	-	14	2336	c.1568G>C	c.(1567-1569)gGt>gCt	p.G523A	TP53BP2_ENST00000391879.2_5'UTR|TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000343537.7_Missense_Mutation_p.G652A	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	646					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TACAGGCTTACCATATACTAA	0.403000													8	82					0	0	0.004482	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120350915	120350915	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:120350915G>T	ENST00000397843.2	+	38	4179	c.4013G>T	c.(4012-4014)cGg>cTg	p.R1338L	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.R1235L|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.R1319L	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1338					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTTGCTCCACGGGATTCAGTG	0.478000			T	MLL	AML								16	44					4.14922e-12	6.87802e-12	0.004007	1	0
PDHA2	5161	broad.mit.edu	37	4	96762193	96762193	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:96762193A>T	ENST00000295266.4	+	1	955	c.892A>T	c.(892-894)Agt>Tgt	p.S298C		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	298					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TCCTGGAGTCAGTTATCGTAC	0.428000													24	33					0	0	0.003954	0	0
FAM149A	25854	broad.mit.edu	37	4	187086567	187086567	+	Silent	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:187086567C>G	ENST00000356371.5	+	11	1986	c.1986C>G	c.(1984-1986)gtC>gtG	p.V662V	FAM149A_ENST00000227065.4_Silent_p.V371V|FAM149A_ENST00000502970.1_Silent_p.V371V|FAM149A_ENST00000514153.1_Silent_p.V371V|FAM149A_ENST00000503432.1_Silent_p.V371V|FAM149A_ENST00000389354.5_Silent_p.V371V			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	662										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		CCCCGCTAGTCACGGAGACCA	0.532000													9	40					0	0	0.008291	0	0
EXO1	9156	broad.mit.edu	37	1	242035553	242035553	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:242035553C>T	ENST00000366548.3	+	12	2080	c.1487C>T	c.(1486-1488)gCa>gTa	p.A496V	EXO1_ENST00000348581.5_Missense_Mutation_p.A496V|EXO1_ENST00000518483.1_Missense_Mutation_p.A496V	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	496					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GAAAGTGGTGCAGTTGTGGTT	0.363000								Editing and processing nucleases					11	47					0	0	0.010729	0	0
CPED1	79974	broad.mit.edu	37	7	120911435	120911435	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:120911435G>T	ENST00000310396.5	+	22	3286	c.2819G>T	c.(2818-2820)gGg>gTg	p.G940V		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATAACAATGGGGCGTTACAAA	0.348000													44	43					5.20006e-24	1.01926e-23	0.011902	1	0
NUP205	23165	broad.mit.edu	37	7	135309933	135309933	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:135309933G>C	ENST00000285968.6	+	32	4527	c.4501G>C	c.(4501-4503)Gat>Cat	p.D1501H		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1501					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GGCTCTACTTGATAGAATTGT	0.413000													18	99					0	0	0.004990	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913726	77913726	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:77913726G>T	ENST00000321110.1	-	2	487	c.192C>A	c.(190-192)ctC>ctA	p.L64L		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	64	Pro-rich.						nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TGTGCTCTGGGAGCTTCTGGG	0.587000													6	15					8.12818e-05	9.70302e-05	0.001984	1	0
ZP4	57829	broad.mit.edu	37	1	238049089	238049089	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:238049089C>A	ENST00000366570.4	-	7	1095	c.937G>T	c.(937-939)Gga>Tga	p.G313*	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	313	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GTGAGGGGTCCAGGCTGGGTC	0.527000													11	38					5.50884e-06	7.0564e-06	0.001368	1	0
STXBP5	134957	broad.mit.edu	37	6	147685201	147685201	+	Silent	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:147685201A>C	ENST00000367481.3	+	23	2980	c.2872A>C	c.(2872-2874)Aga>Cga	p.R958R	STXBP5_ENST00000321680.6_Silent_p.R994R|STXBP5_ENST00000179882.6_Silent_p.R649R|STXBP5_ENST00000367480.3_Silent_p.R941R	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	994					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GCGGATAGCCAGAACGTTCTG	0.363000													13	74					0	0	0.004007	0	0
DNAH11	8701	broad.mit.edu	37	7	21723444	21723444	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:21723444C>G	ENST00000328843.6	+	33	5555	c.5524C>G	c.(5524-5526)Cac>Gac	p.H1842D	DNAH11_ENST00000409508.3_Missense_Mutation_p.H1835D			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1842	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCAACTTCGTCACCGATGGGA	0.443000									Kartagener syndrome				17	155					0	0	0.004007	0	0
LIMK2	3985	broad.mit.edu	37	22	31668610	31668610	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:31668610G>A	ENST00000331728.4	+	13	1592	c.1478G>A	c.(1477-1479)cGc>cAc	p.R493H	LIMK2_ENST00000333611.4_Missense_Mutation_p.R472H|LIMK2_ENST00000406516.1_Missense_Mutation_p.R415H|LIMK2_ENST00000444929.2_Missense_Mutation_p.R247H|LIMK2_ENST00000340552.4_Missense_Mutation_p.R472H	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	493	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						ACCAAGAAACGCACCTTGCGC	0.582000													3	22					0	0	0.004672	0	0
EPHB6	2051	broad.mit.edu	37	7	142561061	142561061	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:142561061G>T	ENST00000392957.2	+	5	863	c.76G>T	c.(76-78)Gtg>Ttg	p.V26L	EPHB6_ENST00000442129.1_Missense_Mutation_p.V26L|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	26						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCTGCTCCTGGTGTCTTCAGT	0.567000													3	51					0.004672	0.0050606	0.004672	1	0
SALL3	27164	broad.mit.edu	37	18	76754811	76754811	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:76754811C>A	ENST00000536229.3	+	1	3130	c.2421C>A	c.(2419-2421)agC>agA	p.S807R	SALL3_ENST00000575389.2_Missense_Mutation_p.S940R|SALL3_ENST00000537592.2_Missense_Mutation_p.S940R			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCCGGACAGCCCAgccgccg	0.731000													3	5					0.004672	0.0050606	0.004672	1	0
SLC9A5	6553	broad.mit.edu	37	16	67290373	67290373	+	Splice_Site	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:67290373G>T	ENST00000299798.11	+	6	978	c.911_splice	c.e6-1	p.V305_splice	SLC9A5_ENST00000561472.2_3'UTR	NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	305					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CTCTCCCAGGGTGACCATGTG	0.547000													12	23					2.68362e-12	4.47878e-12	0.001368	1	0
DMRT2	10655	broad.mit.edu	37	9	1057240	1057240	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:1057240G>A	ENST00000382251.3	+	5	1982	c.1653G>A	c.(1651-1653)agG>agA	p.R551R	DMRT2_ENST00000259622.6_3'UTR|DMRT2_ENST00000302441.6_Silent_p.R551R|DMRT2_ENST00000358146.2_Silent_p.R551R|DMRT2_ENST00000382255.3_3'UTR			Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor 2	551					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)|prostate(2)	4		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TTCTTAAGAGGCCTTCATCTG	0.398000													15	37					0	0	0.004007	0	0
CST11	140880	broad.mit.edu	37	20	23433353	23433353	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:23433353T>A	ENST00000377009.3	-	1	129	c.96A>T	c.(94-96)ctA>ctT	p.L32L	CST11_ENST00000377007.3_Silent_p.L32L	NM_130794.1	NP_570612.1	Q9H112	CST11_HUMAN	cystatin 11	32					defense response to bacterium	cytoplasm|nucleus	cysteine-type endopeptidase inhibitor activity			kidney(2)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	14	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CATGGACGCTTAGAAAGGTTT	0.498000													23	74					0	0	0.003330	0	0
ALOX12	239	broad.mit.edu	37	17	6909277	6909277	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:6909277G>A	ENST00000251535.6	+	10	1402	c.1349G>A	c.(1348-1350)cGg>cAg	p.R450Q	AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000399540.2_Intron|AC027763.2_ENST00000573939.1_Intron|AC027763.2_ENST00000399541.2_Intron|AC027763.2_ENST00000574377.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	450	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						CTGGCTGACCGGGGCCTGCTG	0.617000													7	47					0	0	0.003080	0	0
AKAP6	9472	broad.mit.edu	37	14	33292084	33292084	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:33292084A>T	ENST00000280979.4	+	13	5235	c.5065A>T	c.(5065-5067)Aca>Tca	p.T1689S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1689	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGCATCTCTAACAGAACTTAG	0.443000													19	48					0	0	0.006122	0	0
GRM2	2912	broad.mit.edu	37	3	51746995	51746995	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:51746995G>T	ENST00000395052.3	+	3	1191	c.957G>T	c.(955-957)ctG>ctT	p.L319L	GRM2_ENST00000442933.2_Silent_p.L319L|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	319					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCATCGAGCTGGCCTCCTACC	0.612000													10	24					1.04858e-14	1.87761e-14	0.006214	1	0
PRAM1	84106	broad.mit.edu	37	19	8564440	8564440	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:8564440C>A	ENST00000423345.4	-	2	772	c.252G>T	c.(250-252)ccG>ccT	p.P84P	PRAM1_ENST00000255612.3_Silent_p.P84P			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	132	8 X 12 AA repeats of K-P-P-[PQ]-P-[EQ]- [VAF]-T-D-L-P-K.|Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						CCTCAGGCGGCGGGGGCTTCT	0.667000													10	90					0.000442599	0.00050587	0.006214	1	0
VCAN	1462	broad.mit.edu	37	5	82841424	82841424	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:82841424G>T	ENST00000265077.3	+	9	9899	c.9334G>T	c.(9334-9336)Gta>Tta	p.V3112L	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000512590.2_Missense_Mutation_p.V1310L|VCAN_ENST00000343200.5_Missense_Mutation_p.V2125L|VCAN_ENST00000342785.4_Missense_Mutation_p.V1358L|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Missense_Mutation_p.V371L|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3112	EGF-like 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AACTTCCTACGTATGCACCTG	0.463000													33	77					6.70999e-13	1.13864e-12	0.004289	1	0
XIRP2	129446	broad.mit.edu	37	2	168107258	168107258	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168107258C>A	ENST00000409195.1	+	9	9445	c.9356C>A	c.(9355-9357)cCg>cAg	p.P3119Q	XIRP2_ENST00000409273.1_Missense_Mutation_p.P2897Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.P3119Q|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2944					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACACGCCCACCGTCACCAACT	0.423000													31	30					3.17567e-06	4.15131e-06	0.008361	1	0
RASA2	5922	broad.mit.edu	37	3	141304930	141304930	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:141304930C>T	ENST00000286364.3	+	18	1851	c.1816C>T	c.(1816-1818)Ctg>Ttg	p.L606L	RASA2_ENST00000452898.1_Silent_p.L606L|RASA2_ENST00000509118.1_3'UTR			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	606	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity	p.L606V(2)		NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						GCCTGTGCACCTGAAAGAAGG	0.378000													8	8					0	0	0.004482	0	0
MTMR12	54545	broad.mit.edu	37	5	32243643	32243643	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:32243643A>T	ENST00000382142.3	-	11	1254	c.1084T>A	c.(1084-1086)Tgg>Agg	p.W362R	MTMR12_ENST00000280285.5_Missense_Mutation_p.W362R|MTMR12_ENST00000264934.5_Missense_Mutation_p.W362R	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	362	Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						ATGTCAAGCCAGCTGCTACTT	0.333000													13	64					0	0	0.001368	0	0
OR5H6	79295	broad.mit.edu	37	3	97983944	97983944	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:97983944C>A	ENST00000383696.2	+	1	857	c.816C>A	c.(814-816)acC>acA	p.T272T	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	272			T -> A (in dbSNP:rs9853906).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T272T(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GCCCCCTCACCTTCAAATATC	0.408000													7	33					8.12818e-05	9.70302e-05	0.001984	1	0
MAST1	22983	broad.mit.edu	37	19	12949442	12949442	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:12949442G>A	ENST00000251472.4	+	1	95	c.56G>A	c.(55-57)gGc>gAc	p.G19D	MAST1_ENST00000591495.1_Intron	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	19					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						TCCTTCCCCGGCGGCAGTATG	0.667000													7	18					0	0	0.006214	0	0
POF1B	79983	broad.mit.edu	37	X	84585958	84585958	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:84585958C>A	ENST00000262753.4	-	7	996	c.851G>T	c.(850-852)gGa>gTa	p.G284V	POF1B_ENST00000373145.3_Missense_Mutation_p.G284V	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	284							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						ACAGTACCTTCCTCCAATTCT	0.358000													4	26					0.00909568	0.00969341	0.009096	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227348267	227348267	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:227348267G>C	ENST00000366769.3	-	6	1961	c.670C>G	c.(670-672)Ctg>Gtg	p.L224V	CDC42BPA_ENST00000334218.5_Missense_Mutation_p.L224V|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.L224V|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.L224V|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.L224V|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.L224V|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.L224V	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	224	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ATCAGCTTCAGACAAGAACCA	0.299000													11	73					0	0	0.010729	0	0
SH3GL3	6457	broad.mit.edu	37	15	84241444	84241444	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:84241444G>C	ENST00000324537.5	+	8	975	c.483G>C	c.(481-483)gaG>gaC	p.E161D	SH3GL3_ENST00000427482.2_Missense_Mutation_p.E153D|SH3GL3_ENST00000535412.1_Missense_Mutation_p.E153D|SH3GL3_ENST00000434347.1_Missense_Mutation_p.E161D			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	153	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						ATTTAAAAGAGATCGGGGTAA	0.338000													6	12					0	0	0.001984	0	0
MARCH11	441061	broad.mit.edu	37	5	16177928	16177928	+	Silent	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:16177928C>T	ENST00000332432.8	-	2	799	c.600G>A	c.(598-600)ctG>ctA	p.L200L	MARCH11_ENST00000505509.1_5'UTR	NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	200						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						TCCATTTTAGCAGGCACAGCT	0.438000													31	78					0	0	0.002836	0	0
MMP8	4317	broad.mit.edu	37	11	102586169	102586169	+	Splice_Site	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:102586169C>T	ENST00000236826.3	-	7	1001		c.e7-1			NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)						collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		CCAGAAGTACCTAACGGAACA	0.418000													16	9					0	0	0.003163	0	0
ACKR2	1238	broad.mit.edu	37	3	42906417	42906417	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:42906417C>A	ENST00000422265.1	+	3	598	c.423C>A	c.(421-423)gaC>gaA	p.D141E	ACKR2_ENST00000273145.2_Missense_Mutation_p.D141E|ACKR2_ENST00000471537.1_Intron|ACKR2_ENST00000442925.1_Missense_Mutation_p.D141E|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		TGAGCCTGGACAAGTACCTGG	0.517000													21	90					1.22574e-08	1.81017e-08	0.002299	1	0
LOC647264	647264	broad.mit.edu	37	13	64321217	64321217	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:64321217G>T	ENST00000453638.2	+	1	284	c.284G>T	c.(283-285)gGg>gTg	p.G95V																	endometrium(2)|lung(1)|urinary_tract(1)	4						ttcggctgtgggtatggctgt	0.547000													20	54					8.10497e-08	1.15622e-07	0.010504	1	0
IFRD1	3475	broad.mit.edu	37	7	112098960	112098960	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:112098960C>G	ENST00000403825.3	+	5	715	c.454C>G	c.(454-456)Ctt>Gtt	p.L152V	IFRD1_ENST00000535603.1_Missense_Mutation_p.L102V|IFRD1_ENST00000486688.1_3'UTR|IFRD1_ENST00000005558.4_Missense_Mutation_p.L152V	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	152					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						AGCATCTGTTCTTTGTATTCA	0.408000													11	34					0	0	0.001855	0	0
LNX2	222484	broad.mit.edu	37	13	28122554	28122554	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:28122554T>A	ENST00000316334.3	-	10	2120	c.1991A>T	c.(1990-1992)cAc>cTc	p.H664L		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	664	PDZ 4.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		TAGTGCAGAGTGGCTCATGCC	0.453000													4	13					0	0	0.009096	0	0
NBPF1	55672	broad.mit.edu	37	1	16901707	16901707	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:16901707C>T	ENST00000430580.2	-	20	3024	c.2137G>A	c.(2137-2139)Gat>Aat	p.D713N	NBPF1_ENST00000432949.1_Missense_Mutation_p.D171N|NBPF1_ENST00000287968.8_Missense_Mutation_p.D78N	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	713	NBPF 3.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACATCTTCATCGTCATCGTTG	0.433000													6	372					0	0	0.006214	0	0
FSIP2	401024	broad.mit.edu	37	2	186673154	186673154	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:186673154C>A	ENST00000343098.5	+	17	19388	c.19388C>A	c.(19387-19389)tCa>tAa	p.S6463*	FSIP2_ENST00000424728.1_Nonsense_Mutation_p.S6374*	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AAAAACTTATCAAAGACTGAG	0.353000													4	15					0.00909568	0.00969341	0.009096	1	0
PM20D2	135293	broad.mit.edu	37	6	89859008	89859008	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:89859008G>A	ENST00000275072.4	+	2	585	c.490G>A	c.(490-492)Gaa>Aaa	p.E164K		NM_001010853.1	NP_001010853.1	Q8IYS1	P20D2_HUMAN	peptidase M20 domain containing 2	164							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|skin(1)	12		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)		AACCCCTGCAGAAGAAGATGG	0.403000													23	67					0	0	0.012319	0	0
TTN	7273	broad.mit.edu	37	2	179441663	179441663	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:179441663C>A	ENST00000589042.1	-	324	69623	c.69399G>T	c.(69397-69399)atG>atT	p.M23133I	TTN_ENST00000342175.6_Missense_Mutation_p.M14260I|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.M14068I|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.M14193I|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.M21492I|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.M20565I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21492	Ig-like 118.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTGTCTACCATTTTGACAG	0.393000													36	296					1.07121e-22	2.06667e-22	0.006999	1	0
DNAH3	55567	broad.mit.edu	37	16	20996803	20996803	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:20996803G>A	ENST00000261383.3	-	48	7260	c.7261C>T	c.(7261-7263)Cgt>Tgt	p.R2421C	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2421	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCAGGACACGGCAGATCCTA	0.552000													10	25					0	0	0.008291	0	0
ZBTB24	9841	broad.mit.edu	37	6	109787142	109787142	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:109787142T>C	ENST00000230122.3	-	7	2173	c.2006A>G	c.(2005-2007)cAg>cGg	p.Q669R	MICAL1_ENST00000368952.4_5'UTR	NM_001164313.1|NM_014797.2	NP_001157785.1|NP_055612.2	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24	669					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CTGCAGGTGCTGAGCTGGATC	0.557000													12	49					0	0	0.001368	0	0
BCL6	604	broad.mit.edu	37	3	187447539	187447539	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:187447539C>A	ENST00000406870.2	-	5	1020	c.654G>T	c.(652-654)atG>atT	p.M218I	BCL6_ENST00000232014.4_Missense_Mutation_p.M218I|RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.M218I|RP11-211G3.3_ENST00000449623.1_Intron	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	218					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGGCCACAGGCATCCGGACAT	0.617000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								6	17					0.00116845	0.00130426	0.001168	1	0
C6	729	broad.mit.edu	37	5	41142944	41142944	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:41142944C>T	ENST00000263413.3	-	18	3052	c.2788G>A	c.(2788-2790)Gga>Aga	p.G930R	C6_ENST00000337836.5_Missense_Mutation_p.G930R	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	930	C5b-binding domain.|Complement control factor I module 2.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AAACACTTTCCAGGATGCAGT	0.413000													8	84					0	0	0.004482	0	0
XIST	7503	broad.mit.edu	37	X	73064668	73064668	+	RNA	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:73064668G>T	ENST00000429829.1	-	0	7920					NR_001564.2																						ATTGACCAAGGTGCATGGCTG	0.488000													24	31					4.26978e-12	7.05745e-12	0.003330	1	0
SH2D4B	387694	broad.mit.edu	37	10	82403816	82403816	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:82403816C>A	ENST00000470604.2	+	8	1271	c.1271C>A	c.(1270-1272)cCa>cAa	p.P424Q	SH2D4B_ENST00000313455.4_Silent_p.T303T|SH2D4B_ENST00000339284.2_Silent_p.T351T|SH2D4B_ENST00000372150.3_3'UTR			Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B	424										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)	13			Colorectal(32;0.229)			GACAGCCCACCAGACTACCAT	0.373000													7	23					3.09899e-07	4.27198e-07	0.004482	1	0
KTI12	112970	broad.mit.edu	37	1	52499412	52499412	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:52499412C>T	ENST00000371614.1	-	1	76	c.22G>A	c.(22-24)Ggg>Agg	p.G8R	TXNDC12_ENST00000472624.1_Intron|RP11-91A18.4_ENST00000425802.1_RNA|TXNDC12_ENST00000371626.4_Intron	NM_138417.2	NP_612426.1	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated (S. cerevisiae)	8							ATP binding			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)|urinary_tract(1)	12						TACGGCAGCCCGCAAAACACC	0.672000													3	13					0	0	0.004672	0	0
SLC25A18	83733	broad.mit.edu	37	22	18070036	18070036	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:18070036C>T	ENST00000327451.5	+	8	1082	c.544C>T	c.(544-546)Ctc>Ttc	p.L182F	SLC25A18_ENST00000399813.1_Missense_Mutation_p.L182F|AC004019.13_ENST00000443935.1_RNA	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	182						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	CCTGGCTGGGCTCTACAGGGG	0.652000													12	48					0	0	0.004007	0	0
HOXB1	3211	broad.mit.edu	37	17	46606916	46606916	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:46606916G>A	ENST00000239174.6	-	2	991	c.899C>T	c.(898-900)aCc>aTc	p.T300I	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	300						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AGTTCAGGAGGTGACAGAGCT	0.667000													10	38					0	0	0.010729	0	0
GPR17	2840	broad.mit.edu	37	2	128408417	128408417	+	Silent	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:128408417C>A	ENST00000544369.1	+	4	803	c.192C>A	c.(190-192)tcC>tcA	p.S64S	LIMS2_ENST00000409455.1_Intron|LIMS2_ENST00000324938.5_Intron|LIMS2_ENST00000409808.2_Intron|GPR17_ENST00000486700.1_3'UTR|LIMS2_ENST00000545738.2_Intron|LIMS2_ENST00000355119.4_Intron|GPR17_ENST00000272644.3_Silent_p.S64S|LIMS2_ENST00000410011.1_Intron|GPR17_ENST00000393018.3_Silent_p.S64S	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	64						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		tgttcgcctccttctaccttc	0.572000											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	58					6.44725e-10	9.94868e-10	0.002299	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455035	84455035	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:84455035C>A	ENST00000377084.2	-	1	1493	c.608G>T	c.(607-609)gGt>gTt	p.G203V		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	203						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTCCGCAATACCAGGGATTTG	0.542000													15	46					1.52009e-12	2.56683e-12	0.003163	1	0
SLC26A7	115111	broad.mit.edu	37	8	92375762	92375762	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:92375762A>T	ENST00000276609.3	+	13	1723	c.1484A>T	c.(1483-1485)gAc>gTc	p.D495V	SLC26A7_ENST00000523719.1_Missense_Mutation_p.D495V|SLC26A7_ENST00000309536.2_Missense_Mutation_p.D495V|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	495	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACAGAAATGGACAGTGTAAGT	0.249000													7	22					0	0	0.003080	0	0
EEF1D	1936	broad.mit.edu	37	8	144662227	144662227	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:144662227C>A	ENST00000532400.1	-	3	264	c.209G>T	c.(208-210)tGg>tTg	p.W70L	RP11-661A12.7_ENST00000529247.1_RNA|EEF1D_ENST00000442189.2_Silent_p.V620V|EEF1D_ENST00000532741.1_Silent_p.V670V|EEF1D_ENST00000528610.1_Silent_p.V230V|EEF1D_ENST00000529272.1_Silent_p.V254V|EEF1D_ENST00000423316.2_Silent_p.V620V|EEF1D_ENST00000317198.6_Silent_p.V254V|EEF1D_ENST00000524624.1_Silent_p.V230V|EEF1D_ENST00000419152.2_Silent_p.V254V|EEF1D_ENST00000526838.1_Silent_p.V235V|EEF1D_ENST00000395119.3_Silent_p.V254V|EEF1D_ENST00000531621.1_Silent_p.V211V			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			AGTCTGTCCCCACCTTGTCGT	0.632000													17	24					1.5739e-10	2.48899e-10	0.004007	1	0
SPTBN1	6711	broad.mit.edu	37	2	54874368	54874368	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:54874368G>A	ENST00000333896.5	+	23	5313	c.4928G>A	c.(4927-4929)cGg>cAg	p.R1643Q	SPTBN1_ENST00000356805.4_Missense_Mutation_p.R1656Q	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1656	Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AAGACCAGCCGGGCCCTGGTG	0.562000													6	58					0	0	0.003080	0	0
KLF17	128209	broad.mit.edu	37	1	44595237	44595237	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:44595237G>T	ENST00000372299.3	+	2	352	c.294G>T	c.(292-294)atG>atT	p.M98I	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	98					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGCGTGGTATGAGCTACTGCC	0.567000													36	102					8.05343e-35	1.61538e-34	0.008740	1	0
HYOU1	10525	broad.mit.edu	37	11	118916543	118916543	+	Splice_Site	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:118916543C>A	ENST00000404233.3	-	25	3012	c.2887_splice	c.e25-1	p.G963_splice	HYOU1_ENST00000529972.1_Splice_Site_p.G901_splice|HYOU1_ENST00000525859.1_Splice_Site_p.G901_splice	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	963						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		TGGCTCGGATCCTGCTTTGGG	0.547000													5	34					3.59834e-05	4.44363e-05	0.001168	1	0
VGLL3	389136	broad.mit.edu	37	3	87017913	87017913	+	Missense_Mutation	SNP	A	A	T	rs35544388		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:87017913A>T	ENST00000398399.2	-	3	1127	c.764T>A	c.(763-765)cTg>cAg	p.L255Q	VGLL3_ENST00000383698.3_Missense_Mutation_p.L255Q	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GGATGGATCCAGGGCAGAGCC	0.587000													19	27					0	0	0.007413	0	0
NEB	4703	broad.mit.edu	37	2	152422283	152422283	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:152422283G>C	ENST00000397345.3	-	115	18410	c.18208C>G	c.(18208-18210)Ctg>Gtg	p.L6070V	NEB_ENST00000409198.1_Missense_Mutation_p.L4369V|NEB_ENST00000603639.1_Missense_Mutation_p.L6070V|NEB_ENST00000604864.1_Missense_Mutation_p.L6070V|NEB_ENST00000172853.10_Missense_Mutation_p.L4369V|NEB_ENST00000427231.2_Missense_Mutation_p.L6070V	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6064					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACAGAATCCAGTGGGATCCAG	0.478000													8	8					0	0	0.004482	0	0
FAM131B	9715	broad.mit.edu	37	7	143053913	143053913	+	Silent	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:143053913T>A	ENST00000409408.1	-	6	2437	c.729A>T	c.(727-729)ggA>ggT	p.G243G	FAM131B_ENST00000443739.2_Silent_p.G271G|FAM131B_ENST00000409222.3_Silent_p.G243G|FAM131B_ENST00000409578.1_Silent_p.G259G|FAM131B_ENST00000409346.1_Silent_p.G243G			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	243										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					GAGCAGAGTATCCTGAAGCTG	0.602000													23	96					0	0	0.012319	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355660	33355660	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:33355660G>A	ENST00000023064.4	-	3	301	c.110C>T	c.(109-111)tCc>tTc	p.S37F	SLC7A9_ENST00000590341.1_Missense_Mutation_p.S37F|SLC7A9_ENST00000587772.1_Missense_Mutation_p.S37F	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	37					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CACGATGATGGAGATGCCACT	0.627000													26	114					0	0	0.006320	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22354535	22354535	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:22354535C>G	ENST00000396037.4	-	5	1503	c.1022G>C	c.(1021-1023)aGa>aCa	p.R341T	ST8SIA1_ENST00000539510.1_Missense_Mutation_p.R198T	NM_003034.3	NP_003025.1	Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	341					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						CAGCTGCATTCTCAGTGCACC	0.463000													31	104					0	0	0.008361	0	0
OR4D5	219875	broad.mit.edu	37	11	123810330	123810330	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:123810330C>T	ENST00000307033.2	+	1	81	c.7C>T	c.(7-9)Cca>Tca	p.P3S		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCAGATGAATCCAGCAAATCA	0.418000													9	54					0	0	0.006214	0	0
ABCB4	5244	broad.mit.edu	37	7	87037415	87037415	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:87037415A>G	ENST00000265723.4	-	25	3328	c.3217T>C	c.(3217-3219)Tgt>Cgt	p.C1073R	ABCB4_ENST00000545634.1_Missense_Mutation_p.C1073R|ABCB4_ENST00000359206.3_Missense_Mutation_p.C1073R|ABCB4_ENST00000358400.3_Missense_Mutation_p.C1026R|ABCB4_ENST00000453593.1_Missense_Mutation_p.C1026R	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1073	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTCTTCCCACAGCCACTGCTG	0.572000													26	73					0	0	0.003954	0	0
TCHH	7062	broad.mit.edu	37	1	152084342	152084342	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:152084342G>T	ENST00000368804.1	-	2	1350	c.1351C>A	c.(1351-1353)Cag>Aag	p.Q451K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	451	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctctcctcctgctcgcgcttc	0.682000													11	41					9.31168e-06	1.18569e-05	0.001855	1	0
ADAM22	53616	broad.mit.edu	37	7	87737540	87737540	+	Nonsense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:87737540C>G	ENST00000398204.4	+	5	763	c.440C>G	c.(439-441)tCa>tGa	p.S147*	ADAM22_ENST00000439864.1_Nonsense_Mutation_p.S147*|ADAM22_ENST00000398209.3_Nonsense_Mutation_p.S147*|ADAM22_ENST00000265727.7_Nonsense_Mutation_p.S147*|ADAM22_ENST00000398201.4_Nonsense_Mutation_p.S147*|ADAM22_ENST00000315984.7_Nonsense_Mutation_p.S147*	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	147					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AACCCTGACTCATTTGTTGCA	0.363000													5	41					0	0	0.001168	0	0
LPPR5	163404	broad.mit.edu	37	1	99418878	99418878	+	Splice_Site	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:99418878T>A	ENST00000370188.3	-	3	731		c.e3-2		LPPR5_ENST00000263177.4_Splice_Site	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN								integral to membrane	hydrolase activity										TATAAATTCCTGGGGAAGAAA	0.388000													8	11					0	0	0.003080	0	0
OR5M10	390167	broad.mit.edu	37	11	56345131	56345131	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:56345131G>C	ENST00000526812.2	-	1	132	c.67C>G	c.(67-69)Cta>Gta	p.L23V		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						ATCTTCTCTAGCACTGGGTCG	0.463000													21	81					0	0	0.012319	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177226	89177226	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:89177226G>T	ENST00000561129.2	+	1	272	c.142G>T	c.(142-144)Gag>Tag	p.E48*	TGIF2LX_ENST00000283891.5_Nonsense_Mutation_p.E48*			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	48						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						TGCCTTACCAGAGCACAAGAA	0.517000													4	30					0.00909568	0.00969341	0.009096	1	0
AE000661.37	0	broad.mit.edu	37	14	22932185	22932185	+	RNA	SNP	T	T	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:22932185T>A	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA|TRDC_ENST00000390477.2_RNA																							GACTTTGAAGTGAAGACAGAT	0.403000													6	47					0	0	0.001984	0	0
MSGN1	343930	broad.mit.edu	37	2	17998011	17998011	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:17998011A>C	ENST00000281047.3	+	1	249	c.226A>C	c.(226-228)Agt>Cgt	p.S76R		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	76					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CGGGGCCAGCAGTGGGGGCAG	0.637000													19	36					0	0	0.007413	0	0
ZNF99	7652	broad.mit.edu	37	19	22939489	22939489	+	Silent	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:22939489G>T	ENST00000397104.3	-	7	2681	c.2682C>A	c.(2680-2682)ggC>ggA	p.G894G						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAAAACCTTTGCCACATTCTT	0.353000													4	26					0.00909568	0.00969341	0.009096	1	0
FLNC	2318	broad.mit.edu	37	7	128482971	128482971	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:128482971C>G	ENST00000325888.8	+	16	2774	c.2513C>G	c.(2512-2514)gCg>gGg	p.A838G	FLNC_ENST00000346177.6_Missense_Mutation_p.A838G	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	838					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCACCAGGGGCGGGCCGCTAC	0.592000													15	34					0	0	0.004990	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967313	106967313	+	RNA	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:106967313C>T	ENST00000390622.2	-	0	390																											GCTTCTTCACCTCAGCCCCAG	0.552000													15	55					0	0	0.002450	0	0
FAM188B	84182	broad.mit.edu	37	7	30825406	30825406	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:30825406C>T	ENST00000265299.6	+	4	538	c.461C>T	c.(460-462)tCa>tTa	p.S154L	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	154										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AATTTTGTATCATCTAAAAGG	0.428000													16	75					0	0	0.003163	0	0
MUC16	94025	broad.mit.edu	37	19	9066013	9066013	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:9066013G>T	ENST00000397910.4	-	3	21636	c.21433C>A	c.(21433-21435)Cca>Aca	p.P7145T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7147	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACAAGTTCTGGGCTTGTGTGT	0.498000													35	43					6.90743e-12	1.13626e-11	0.003755	1	0
KLK2	3817	broad.mit.edu	37	19	51379746	51379746	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51379746G>A	ENST00000325321.3	+	3	450	c.225G>A	c.(223-225)ctG>ctA	p.L75L	KLK2_ENST00000358049.4_Silent_p.L75L|KLK2_ENST00000391810.2_5'UTR|KLK2_ENST00000597509.1_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	75	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		AGGTCTGGCTGGGTCGGCACA	0.572000			T	ETV4	prostate								7	11					0	0	0.001984	0	0
FAT3	120114	broad.mit.edu	37	11	92086959	92086959	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:92086959G>A	ENST00000298047.6	+	1	1698	c.1681G>A	c.(1681-1683)Gag>Aag	p.E561K	FAT3_ENST00000409404.2_Missense_Mutation_p.E561K|FAT3_ENST00000525166.1_Missense_Mutation_p.E411K|FAT3_ENST00000541502.1_Missense_Mutation_p.E561K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	561	Cadherin 5.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCATGAAAGTGAGGTCAATGT	0.423000										TCGA Ovarian(4;0.039)			11	62					0	0	0.008291	0	0
NEDD4	4734	broad.mit.edu	37	15	56130727	56130727	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:56130727C>T	ENST00000508342.1	-	18	3663	c.3364G>A	c.(3364-3366)Gat>Aat	p.D1122N	NEDD4_ENST00000338963.2_Missense_Mutation_p.D1050N|NEDD4_ENST00000506154.1_Missense_Mutation_p.D1106N|NEDD4_ENST00000435532.3_Missense_Mutation_p.D703N			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1122	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity	p.D1050N(1)|p.D703N(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		AGTTCTTCATCTATGATAAAC	0.308000													9	12					0	0	0.006214	0	0
LYRM2	57226	broad.mit.edu	37	6	90347478	90347478	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:90347478T>C	ENST00000523377.1	-	2	205	c.169A>G	c.(169-171)Aaa>Gaa	p.K57E	LYRM2_ENST00000520441.1_Missense_Mutation_p.K57E|LYRM2_ENST00000517396.1_5'UTR|LYRM2_ENST00000520318.1_Missense_Mutation_p.K57E	NM_020466.4	NP_065199.1	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	57										kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		GTGGCACTTTTGTTTCTTCTG	0.373000													35	124					0	0	0.006999	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156651182	156651182	+	Splice_Site	SNP	A	A	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr4:156651182A>T	ENST00000296518.7	+	10	2081	c.1871_splice	c.e10-1	p.R624_splice	GUCY1A3_ENST00000511108.1_Splice_Site_p.R624_splice|GUCY1A3_ENST00000455639.2_Splice_Site_p.R624_splice|GUCY1A3_ENST00000513574.1_Splice_Site_p.R624_splice|GUCY1A3_ENST00000506455.1_Splice_Site_p.R624_splice|GUCY1A3_ENST00000393832.3_Splice_Site_p.R366_splice			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	624					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATATTTTCAGATTACTCAAAG	0.363000													3	26					0	0	0.004672	0	0
TTC18	118491	broad.mit.edu	37	10	75072269	75072269	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:75072269C>A	ENST00000310715.3	-	11	1375	c.1255G>T	c.(1255-1257)Gaa>Taa	p.E419*	TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000401621.2_Nonsense_Mutation_p.E419*|TTC18_ENST00000394865.1_Nonsense_Mutation_p.E419*	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	419							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					ATATCCTTTTCTTTCACTGGT	0.388000													9	110					1.76689e-08	2.57834e-08	0.006214	1	0
CDH9	1007	broad.mit.edu	37	5	26881700	26881700	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:26881700G>T	ENST00000231021.4	-	12	2087	c.1915C>A	c.(1915-1917)Caa>Aaa	p.Q639K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	639					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTTTTCTTTGCCTCTTCAAT	0.393000													32	40					2.61193e-14	4.60976e-14	0.009535	1	0
PLEKHA6	22874	broad.mit.edu	37	1	204228631	204228631	+	Silent	SNP	G	G	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:204228631G>A	ENST00000272203.3	-	8	1078	c.762C>T	c.(760-762)ccC>ccT	p.P254P	PLEKHA6_ENST00000414478.1_Silent_p.P274P	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	254	Pro-rich.									breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TTGGGCCCTCGGGGTAAGGGC	0.662000													7	38					0	0	0.001984	0	0
IL23R	149233	broad.mit.edu	37	1	67724433	67724434	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:67724433_67724434insA	ENST00000347310.5	+	11	1683_1684	c.1512_1513insA	c.(1510-1515)atcttcfs	p.F505fs	IL23R_ENST00000395227.1_Frame_Shift_Ins_p.F250fs|IL23R_ENST00000371002.1_3'UTR|IL23R_ENST00000473881.1_3'UTR	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	505					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						ATAATGAAATTACTTCCTTAAC	0.347													13	28	---	---	---	---					
ASH1L	55870	broad.mit.edu	37	1	155451048	155451048	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:155451048delG	ENST00000368346.3	-	3	2252	c.1613delC	c.(1612-1614)ttfs	p.S538fs	ASH1L_ENST00000392403.3_Frame_Shift_Del_p.S538fs			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	538					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AGATACATCAGAAGCACCTCC	0.438													8	73	---	---	---	---					
SUCO	51430	broad.mit.edu	37	1	172501855	172501856	+	Frame_Shift_Ins	INS	-	-	T	rs74124228	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:172501855_172501856insT	ENST00000367723.3	+	1	367_368	c.243_244insT	c.(241-246)gagggafs	p.E81fs		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		CTAGGAGGGACTGGGAAAGAGA	0.510													8	34	---	---	---	---					
TNR	7143	broad.mit.edu	37	1	175355240	175355240	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:175355240delG	ENST00000367674.1	-	8	2413	c.1705delC	c.(1705-1707)gafs	p.R569fs	TNR_ENST00000263525.2_Frame_Shift_Del_p.R569fs	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	569	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACCTCGTATCGGGAGCCAGGC	0.627													19	72	---	---	---	---					
OR2M5	127059	broad.mit.edu	37	1	248308469	248308469	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:248308469delC	ENST00000366476.1	+	1	20	c.20delC	c.(19-21)acfs	p.T7fs		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T7N(1)		NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAGAATCAGACCTTCAACTCT	0.428													50	201	---	---	---	---					
SH3BP5L	80851	broad.mit.edu	37	1	249106309	249106309	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr1:249106309delG	ENST00000366472.5	-	7	2201	c.972delC	c.(970-972)ccfs	p.P324fs	SH3BP5L_ENST00000475978.1_5'UTR|SH3BP5L_ENST00000411742.2_Frame_Shift_Del_p.P292fs	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	324										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGGCGGGGCCGGGCCCCAGGC	0.711													8	36	---	---	---	---					
PXDN	7837	broad.mit.edu	37	2	1667450	1667451	+	Frame_Shift_Ins	INS	-	-	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:1667450_1667451insC	ENST00000252804.4	-	12	1543_1544	c.1493_1494insG	c.(1492-1494)gcafs	p.A498fs		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	498	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATTCGTACTGGCCCTGGTCGTG	0.619													8	102	---	---	---	---					
NRXN1	9378	broad.mit.edu	37	2	50724570	50724571	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:50724570_50724571insT	ENST00000404971.1	-	15	4238_4239	c.2899_2900insA	c.(2899-2901)gcafs	p.A967fs	NRXN1_ENST00000401669.2_Frame_Shift_Ins_p.A927fs|NRXN1_ENST00000406859.3_Frame_Shift_Ins_p.A927fs|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000405472.3_Frame_Shift_Ins_p.A919fs|NRXN1_ENST00000406316.2_Frame_Shift_Ins_p.A927fs|NRXN1_ENST00000402717.3_Frame_Shift_Ins_p.A919fs	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	927	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAAAGATGCATAGAAGTGTAG	0.396													11	28	---	---	---	---					
CNTNAP5	129684	broad.mit.edu	37	2	125530420	125530421	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:125530420_125530421insT	ENST00000431078.1	+	17	2939_2940	c.2575_2576insT	c.(2575-2577)ggafs	p.G859fs		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	859	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.V859A(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GAATGGTCCTGTGGAGCTTGTA	0.510													16	75	---	---	---	---					
ARHGAP15	55843	broad.mit.edu	37	2	143973977	143973978	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:143973977_143973978insA	ENST00000409869.1	+	5	436_437	c.259_260insA	c.(259-261)aaafs	p.K87fs	ARHGAP15_ENST00000295095.6_Frame_Shift_Ins_p.K87fs			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	87	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		AGGTTATCTGCAAAAAGCTAAA	0.312													17	78	---	---	---	---					
ZEB2	9839	broad.mit.edu	37	2	145187395	145187395	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:145187395delC	ENST00000558170.2	-	3	1456	c.272delG	c.(271-273)gtfs	p.G92fs	ZEB2_ENST00000303660.4_Frame_Shift_Del_p.G92fs|ZEB2_ENST00000409487.3_Frame_Shift_Del_p.G92fs|ZEB2_ENST00000539609.3_Frame_Shift_Del_p.G92fs	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	92						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTCCACTCCACCCTCCCTTAT	0.517													15	79	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168102600	168102600	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:168102600delG	ENST00000409195.1	+	9	4787	c.4698delG	c.(4696-4698)cafs	p.Q1566fs	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Del_p.Q1566fs|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Del_p.Q1344fs	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1391					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGTTATCCAGGCTCCTGGAA	0.353													16	31	---	---	---	---					
CCDC108	255101	broad.mit.edu	37	2	219900384	219900384	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr2:219900384delG	ENST00000341552.5	-	5	443	c.360delC	c.(358-360)ccfs	p.P120fs	CCDC108_ENST00000410037.1_Frame_Shift_Del_p.P55fs|CCDC108_ENST00000409865.3_Frame_Shift_Del_p.P109fs|CCDC108_ENST00000324264.6_Frame_Shift_Del_p.P55fs|CCDC108_ENST00000295729.2_Frame_Shift_Del_p.P55fs|CCDC108_ENST00000453220.1_Frame_Shift_Del_p.P120fs|CCDC108_ENST00000441968.1_Frame_Shift_Del_p.P120fs	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	120						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGAGCTTGCGGGCTGTTCAG	0.567													14	27	---	---	---	---					
C3orf20	84077	broad.mit.edu	37	3	14770100	14770100	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:14770100delA	ENST00000253697.3	+	12	2297	c.1845delA	c.(1843-1845)tcfs	p.S615fs	C3orf20_ENST00000412910.1_Frame_Shift_Del_p.S493fs|C3orf20_ENST00000435614.1_Frame_Shift_Del_p.S493fs	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	615						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TGGAATCCTCAATTGCAGAGA	0.502													7	34	---	---	---	---					
KLHL18	23276	broad.mit.edu	37	3	47382105	47382105	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:47382105delG	ENST00000232766.5	+	8	1185	c.1165delG	c.(1165-1167)ggfs	p.G390fs	KLHL18_ENST00000455924.2_Frame_Shift_Del_p.G278fs	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	390										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CTACGTCTGTGGGGGCTACGA	0.577													21	95	---	---	---	---					
SEMA5B	54437	broad.mit.edu	37	3	122641169	122641170	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr3:122641169_122641170insT	ENST00000195173.4	-	11	1700_1701	c.1397_1398insA	c.(1396-1398)cgafs	p.R466fs	SEMA5B_ENST00000451055.2_Frame_Shift_Ins_p.R520fs|SEMA5B_ENST00000357599.3_Frame_Shift_Ins_p.R466fs			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	466	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCACGCTGTCCTGGGTGACACA	0.649													10	18	---	---	---	---					
FAM173B	134145	broad.mit.edu	37	5	10239355	10239356	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:10239355_10239356insA	ENST00000511437.1	-	2	141_142	c.129_130insT	c.(127-132)cttgggfs	p.G44fs	FAM173B_ENST00000280330.8_5'UTR|FAM173B_ENST00000510047.1_Frame_Shift_Ins_p.G44fs|FAM173B_ENST00000510052.1_5'UTR	NM_199133.3	NP_954584.2	Q6P4H8	F173B_HUMAN	family with sequence similarity 173, member B	44						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	16						GTGCCACCCACAAGCCCAGTAA	0.480													23	254	---	---	---	---					
ROPN1L	83853	broad.mit.edu	37	5	10461430	10461431	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:10461430_10461431insT	ENST00000503804.1	+	5	1073_1074	c.552_553insT	c.(550-555)cctggafs	p.G185fs	ROPN1L_ENST00000274134.4_Frame_Shift_Ins_p.G185fs|ROPN1L_ENST00000510520.1_3'UTR			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	185					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						ATGTGTCTCCCTTGGAGACGGA	0.505													53	291	---	---	---	---					
DNAH5	1767	broad.mit.edu	37	5	13701425	13701426	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:13701425_13701426insA	ENST00000265104.4	-	77	13562_13563	c.13458_13459insT	c.(13456-13461)ttacccfs	p.LP4486fs		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4486					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCTGGGGGTTAAAAAAACCCG	0.426									Kartagener syndrome				18	203	---	---	---	---					
GPR150	285601	broad.mit.edu	37	5	94956920	94956920	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr5:94956920delC	ENST00000380007.2	+	1	1139	c.941delC	c.(940-942)gcfs	p.A314fs		NM_199243.1	NP_954713.1	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	314						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(2)	2		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		TACTTTGCCGCCCGGCTGGCG	0.741													3	3	---	---	---	---					
TUBB2B	347733	broad.mit.edu	37	6	3225019	3225020	+	Frame_Shift_Ins	INS	-	-	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:3225019_3225020insC	ENST00000259818.7	-	4	1494_1495	c.1303_1304insG	c.(1303-1305)gttfs	p.V435fs	TUBB2B_ENST00000473006.1_5'UTR	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	435					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				CTCCTCGAACTCCCCTTGTTCG	0.653													11	57	---	---	---	---					
TTK	7272	broad.mit.edu	37	6	80715639	80715639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr6:80715639delT	ENST00000509894.1	+	2	908	c.79delT	c.(79-81)ttfs	p.F27fs	TTK_ENST00000369798.2_Frame_Shift_Del_p.F27fs|TTK_ENST00000230510.3_Frame_Shift_Del_p.F27fs			P33981	TTK_HUMAN	TTK protein kinase	27					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TAAAAATAAGTTTAAAAATGA	0.303													24	23	---	---	---	---					
CCDC126	90693	broad.mit.edu	37	7	23651005	23651005	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:23651005delT	ENST00000307471.3	+	3	528	c.71delT	c.(70-72)atfs	p.I24fs	CCDC126_ENST00000410069.1_Frame_Shift_Del_p.I24fs|CCDC126_ENST00000409765.1_Frame_Shift_Del_p.I24fs|CCDC126_ENST00000486109.1_3'UTR	NM_138771.3	NP_620126.2	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126	24						extracellular region				endometrium(3)|kidney(1)|large_intestine(1)|ovary(1)|skin(1)	7						TTTGGACTCATTTGGGGATTG	0.338													7	47	---	---	---	---					
ZKSCAN5	23660	broad.mit.edu	37	7	99123799	99123800	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:99123799_99123800insT	ENST00000394170.2	+	6	1387_1388	c.1136_1137insT	c.(1135-1137)tggfs	p.W379fs	ZKSCAN5_ENST00000326775.5_Frame_Shift_Ins_p.W379fs|ZKSCAN5_ENST00000451158.1_Frame_Shift_Ins_p.W379fs	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	379					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGCGGAGAATGTGGGAAGAGCT	0.535													9	130	---	---	---	---					
CHRM2	1129	broad.mit.edu	37	7	136701006	136701007	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr7:136701006_136701007insT	ENST00000445907.2	+	3	1922_1923	c.1394_1395insT	c.(1393-1395)aagfs	p.K465fs	AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000401861.1_Frame_Shift_Ins_p.K465fs|CHRM2_ENST00000320658.5_Frame_Shift_Ins_p.K465fs|CHRM2_ENST00000397608.3_Frame_Shift_Ins_p.K465fs|CHRM2_ENST00000402486.3_Frame_Shift_Ins_p.K465fs|CHRM2_ENST00000453373.1_Frame_Shift_Ins_p.K465fs|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	465					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATAGGCGCTACAAGGTAAAATA	0.406													30	51	---	---	---	---					
CSMD1	64478	broad.mit.edu	37	8	2949144	2949144	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr8:2949144delC	ENST00000602557.1	-	49	7737	c.7182delG	c.(7180-7182)ggfs	p.G2394fs	CSMD1_ENST00000542608.1_Frame_Shift_Del_p.G2393fs|CSMD1_ENST00000400186.3_Frame_Shift_Del_p.G2394fs|CSMD1_ENST00000537824.1_Frame_Shift_Del_p.G2393fs|CSMD1_ENST00000520002.1_Frame_Shift_Del_p.G2394fs|CSMD1_ENST00000602723.1_Frame_Shift_Del_p.G2394fs			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2394	CUB 14.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGTATGATTCCCACTTAAGA	0.408													6	13	---	---	---	---					
KIAA2026	158358	broad.mit.edu	37	9	5968043	5968044	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:5968043_5968044insT	ENST00000399933.3	-	3	2186_2187	c.2187_2188insA	c.(2185-2190)aacaaafs	p.NK729fs	KIAA2026_ENST00000381461.2_Frame_Shift_Ins_p.NK729fs	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	729	Lys-rich.							p.A730fs*15(1)		breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTGTGTTTTGCTTTTTTTTTGA	0.327													2	4	---	---	---	---					
C9orf172	389813	broad.mit.edu	37	9	139740876	139740876	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr9:139740876delC	ENST00000436881.1	+	1	2010	c.2010delC	c.(2008-2010)tgfs	p.C670fs		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	670										endometrium(2)|large_intestine(1)|lung(6)	9						ATGCGCGCTGCCGGCGCACCG	0.701													10	24	---	---	---	---					
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>AGGAGGggg	p.428_429insRR	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insRR	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													4	5	---	---	---	---					
GLUD1P7	414212	broad.mit.edu	37	10	48966970	48966970	+	RNA	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr10:48966970delG	ENST00000594520.1	+	0	716																											ttttgtttttgtttttgcttt	0.468													13	24	---	---	---	---					
PHRF1	57661	broad.mit.edu	37	11	608054	608064	+	Frame_Shift_Del	DEL	CAGCCCGAAGG	CAGCCCGAAGG	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:608054_608064delCAGCCCGAAGG	ENST00000264555.5	+	14	2726_2736	c.2598_2608delCAGCCCGAAGG	c.(2596-2610)aaccfs	p.NSPKA866fs	PHRF1_ENST00000413872.2_Frame_Shift_Del_p.NSPKA864fs|PHRF1_ENST00000533464.1_Frame_Shift_Del_p.NSPKA862fs|PHRF1_ENST00000416188.2_Frame_Shift_Del_p.NSPKA865fs	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	866							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						TCTCCATCAACAGCCCGAAGGCCCAGACGGT	0.673													13	84	---	---	---	---					
ASCL3	56676	broad.mit.edu	37	11	8959302	8959303	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:8959302_8959303insT	ENST00000325884.1	-	2	465_466	c.406_407insA	c.(406-408)agcfs	p.S136fs	ASCL3_ENST00000531618.1_Frame_Shift_Ins_p.S136fs	NM_020646.1	NP_065697.1	Q9NQ33	ASCL3_HUMAN	achaete-scute family bHLH transcription factor 3	135	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus	DNA binding			breast(1)|large_intestine(2)|lung(5)|stomach(1)	9				Epithelial(150;1.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0228)		GATCGCAGCTCTGAGGGTTTCC	0.490													10	39	---	---	---	---					
METTL15	196074	broad.mit.edu	37	11	28318438	28318438	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:28318438delC	ENST00000342303.5	+	6	1193	c.738delC	c.(736-738)tafs	p.Y246fs	METTL15_ENST00000303459.6_Frame_Shift_Del_p.Y246fs|METTL15_ENST00000406787.3_Frame_Shift_Del_p.P232fs|METTL15_ENST00000407364.3_Frame_Shift_Del_p.Y246fs	NM_152636.2	NP_689849.2	A6NJ78	MET15_HUMAN	methyltransferase like 15	246							methyltransferase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	14						GCAGCATCTACCCCATCACCA	0.448													19	87	---	---	---	---					
OR4C15	81309	broad.mit.edu	37	11	55322642	55322642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55322642delG	ENST00000314644.2	+	1	860	c.860delG	c.(859-861)tgfs	p.W287fs		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GAAGGGCGCTGGAAAGCTCTC	0.438										HNSCC(20;0.049)			48	92	---	---	---	---					
OR4C16	219428	broad.mit.edu	37	11	55339859	55339859	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55339859delA	ENST00000314634.3	+	1	256	c.256delA	c.(256-258)agfs	p.K87fs		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K86*(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TGCCCTTTTGAAGAAGACAAC	0.433													50	188	---	---	---	---					
OR8H2	390151	broad.mit.edu	37	11	55872601	55872602	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:55872601_55872602delTG	ENST00000313503.1	+	1	83_84	c.83_84delTG	c.(82-84)cfs	p.L28fs		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CAGATGGCTCTGTTTATGCTAT	0.431										HNSCC(53;0.14)			67	116	---	---	---	---					
FOSL1	8061	broad.mit.edu	37	11	65664461	65664461	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:65664461delG	ENST00000312562.2	-	2	302	c.116delC	c.(115-117)cafs	p.P39fs	FOSL1_ENST00000531493.1_Frame_Shift_Del_p.P39fs|FOSL1_ENST00000532401.1_Frame_Shift_Del_p.P39fs|FOSL1_ENST00000448083.2_Intron	NM_005438.3	NP_005429.1	P15407	FOSL1_HUMAN	FOS-like antigen 1	39					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	10				READ - Rectum adenocarcinoma(159;0.168)		GTTGATGCTTGGCACCAGGTG	0.557													16	50	---	---	---	---					
CATSPER1	117144	broad.mit.edu	37	11	65788097	65788098	+	Splice_Site	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:65788097_65788098insA	ENST00000312106.5	-	7	2065_2066	c.1927_splice	c.e7-1	p.G643_splice		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	643					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						TGTACCAGGCGCCTAGGGGGAG	0.594													8	35	---	---	---	---					
CRTAM	56253	broad.mit.edu	37	11	122742061	122742061	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr11:122742061delC	ENST00000227348.4	+	10	1183	c.1136delC	c.(1135-1137)tafs	p.S379fs	CRTAM_ENST00000533709.1_Frame_Shift_Del_p.S180fs	NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	379					cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GTACAACATTCAAAATTAGAA	0.413													25	44	---	---	---	---					
CAPZA3	93661	broad.mit.edu	37	12	18891436	18891436	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:18891436delG	ENST00000317658.3	+	1	392	c.234delG	c.(232-234)atfs	p.M78fs		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	78					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				ACAATGTAATGGGCGACTACC	0.423													16	55	---	---	---	---					
NTS	4922	broad.mit.edu	37	12	86268206	86268207	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr12:86268206_86268207insA	ENST00000256010.6	+	1	132_133	c.25_26insA	c.(25-27)tgtfs	p.C9fs	NTS_ENST00000551529.1_Frame_Shift_Ins_p.C9fs	NM_006183.4	NP_006174.1	P30990	NEUT_HUMAN	neurotensin	9					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity			large_intestine(2)|lung(6)	8						GAAAATCCAGCTTGTATGCATG	0.446													27	61	---	---	---	---					
ALG11	440138	broad.mit.edu	37	13	52598351	52598351	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:52598351delA	ENST00000521508.1	+	3	490	c.485delA	c.(484-486)gafs	p.E162fs	ALG11_ENST00000519151.1_3'UTR|ALG11_ENST00000523764.1_Intron	NM_001004127.2	NP_001004127.2			ALG11, alpha-1,2-mannosyltransferase											endometrium(1)|large_intestine(6)|lung(4)|ovary(2)	13		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.44e-08)		CTTGGCTGGGAAGCTCTAATG	0.423													16	87	---	---	---	---					
KLHL1	57626	broad.mit.edu	37	13	70681505	70681505	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr13:70681505delC	ENST00000377844.4	-	1	1086	c.327delG	c.(325-327)ggfs	p.G109fs	KLHL1_ENST00000545028.1_5'UTR|ATXN8OS_ENST00000414504.2_RNA	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	109					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GAGTGCCCTGCCCAGGAGCCC	0.602													17	50	---	---	---	---					
OR4K5	79317	broad.mit.edu	37	14	20389492	20389493	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20389492_20389493insA	ENST00000315915.4	+	1	752_753	c.727_728insA	c.(727-729)tatfs	p.Y243fs		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTGGCTTCCCATATTGCAGTA	0.401													35	145	---	---	---	---					
OR4K1	79544	broad.mit.edu	37	14	20404324	20404324	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:20404324delC	ENST00000285600.4	+	1	558	c.499delC	c.(499-501)cafs	p.P167fs		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AGTGGACCTGCCATTCTGTGG	0.458													20	84	---	---	---	---					
CYP46A1	10858	broad.mit.edu	37	14	100182233	100182233	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:100182233delC	ENST00000554176.1	+	3	987	c.321delC	c.(319-321)cgfs	p.R109fs	CYP46A1_ENST00000261835.3_Frame_Shift_Del_p.R262fs|CYP46A1_ENST00000423126.2_Frame_Shift_Del_p.R165fs			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	262					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGGTCCAGCGCCGCCGGGAAG	0.647													10	28	---	---	---	---					
EVL	51466	broad.mit.edu	37	14	100551124	100551125	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr14:100551124_100551125delAT	ENST00000544450.2	+	2	407_408	c.124_125delAT	c.(124-126)cfs	p.I42fs	EVL_ENST00000402714.2_Frame_Shift_Del_p.I36fs|EVL_ENST00000392920.3_Frame_Shift_Del_p.I38fs|EVL_ENST00000555048.1_3'UTR			Q9UI08	EVL_HUMAN	Enah/Vasp-like	36	WH1.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				ATTCAGCCGGATCAACATCTAC	0.510													20	62	---	---	---	---					
LRRC57	255252	broad.mit.edu	37	15	42840305	42840306	+	Splice_Site	DEL	CA	CA	-	rs150825131		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr15:42840305_42840306delCA	ENST00000323443.2	-	2	588_589	c.223_splice	c.e2+1	p.L74_splice	LRRC57_ENST00000397130.3_Splice_Site_p.L74_splice|LRRC57_ENST00000563454.1_Splice_Site_p.L74_splice			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	74										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		GAGCCATACTCAGTTTGTTGTT	0.465													10	51	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32126964	32126964	+	RNA	DEL	T	T	-	rs77063499		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:32126964delT	ENST00000564145.1	-	0	456																											TTGCCCCCCCTGCCGCCGCGG	0.692													2	4	---	---	---	---					
HYDIN	54768	broad.mit.edu	37	16	70977826	70977826	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr16:70977826delC	ENST00000393567.2	-	42	6708	c.6558delG	c.(6556-6558)ggfs	p.G2186fs		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2186										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGTGGATGGGCCCCGGGGGGA	0.582													11	17	---	---	---	---					
GAA	2548	broad.mit.edu	37	17	78083808	78083808	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr17:78083808delG	ENST00000302262.3	+	9	1610	c.1391delG	c.(1390-1392)agfs	p.R464fs	GAA_ENST00000390015.3_Frame_Shift_Del_p.R464fs	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	464					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGTCTGCGGAGGGGGGTTTTC	0.657													16	86	---	---	---	---					
CEP76	79959	broad.mit.edu	37	18	12697226	12697227	+	Frame_Shift_Ins	INS	-	-	C			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:12697226_12697227insC	ENST00000262127.2	-	5	926_927	c.701_702insG	c.(700-702)ggtfs	p.G234fs	RP11-973H7.2_ENST00000585331.1_RNA|CEP76_ENST00000423709.2_Frame_Shift_Ins_p.G159fs	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	234					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCATACCTACACCCATAAGTTC	0.342													19	20	---	---	---	---					
ZNF236	7776	broad.mit.edu	37	18	74583718	74583718	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr18:74583718delC	ENST00000253159.8	+	5	796	c.598delC	c.(598-600)cgfs	p.P200fs	ZNF236_ENST00000583095.1_Intron|ZNF236_ENST00000320610.9_Frame_Shift_Del_p.P202fs	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	200					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTATTCGTGTCCGCACTGTGG	0.438													20	53	---	---	---	---					
SHANK1	50944	broad.mit.edu	37	19	51175344	51175344	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:51175344delG	ENST00000293441.1	-	21	2623	c.2605delC	c.(2605-2607)agfs	p.Q869fs	SHANK1_ENST00000391814.1_Frame_Shift_Del_p.Q877fs|SHANK1_ENST00000391813.1_Frame_Shift_Del_p.Q256fs|SHANK1_ENST00000359082.3_Frame_Shift_Del_p.Q860fs	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	869					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TAACTTGGCTGGGCACGGTGG	0.562													11	8	---	---	---	---					
ZNF534	147658	broad.mit.edu	37	19	52941322	52941322	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:52941322delC	ENST00000332323.6	+	4	709	c.648delC	c.(646-648)aafs	p.N216fs	ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Frame_Shift_Del_p.N203fs	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						GCCTTACTAACCGTCAAGTAA	0.388													13	44	---	---	---	---					
LILRB5	10990	broad.mit.edu	37	19	54758761	54758762	+	Frame_Shift_Ins	INS	-	-	G	rs149797743	byFrequency	TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:54758761_54758762insG	ENST00000450632.1	-	6	1141_1142	c.1064_1065insC	c.(1063-1065)cctfs	p.P355fs	LILRB5_ENST00000316219.5_Frame_Shift_Ins_p.P364fs|LILRB5_ENST00000345866.6_Frame_Shift_Ins_p.P264fs|LILRB5_ENST00000449561.2_Frame_Shift_Ins_p.P364fs			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	364	Ig-like C2-type 4.			L -> S (in Ref. 2; BAB71361).	cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity	p.P364Q(1)|p.P355Q(1)		NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTAGACACAGCGGGGGATGGGC	0.550													12	43	---	---	---	---					
BRSK1	84446	broad.mit.edu	37	19	55815133	55815133	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr19:55815133delG	ENST00000309383.1	+	12	1502	c.1225delG	c.(1225-1227)ggfs	p.G412fs	BRSK1_ENST00000326848.7_Frame_Shift_Del_p.G107fs|BRSK1_ENST00000590333.1_Frame_Shift_Del_p.G428fs	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	412					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CACCGATGCCGGGGGTGGTGG	0.662													13	37	---	---	---	---					
EPB41L1	2036	broad.mit.edu	37	20	34809839	34809840	+	Frame_Shift_Ins	INS	-	-	G			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr20:34809839_34809840insG	ENST00000338074.2	+	20	2654_2655	c.2493_2494insG	c.(2491-2496)acgggafs	p.TG831fs	EPB41L1_ENST00000373946.3_Frame_Shift_Ins_p.TG651fs|EPB41L1_ENST00000373950.2_Frame_Shift_Ins_p.TG722fs|EPB41L1_ENST00000373941.1_Frame_Shift_Ins_p.TG830fs|EPB41L1_ENST00000202028.5_Frame_Shift_Ins_p.TG729fs|EPB41L1_ENST00000441639.1_Frame_Shift_Ins_p.TG729fs	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	831	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					TCATCATTACTGGGGATGAAGA	0.540													49	67	---	---	---	---					
MN1	4330	broad.mit.edu	37	22	28194910	28194912	+	In_Frame_Del	DEL	TGT	TGT	-	rs45520238		TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:28194910_28194912delTGT	ENST00000302326.4	-	1	2574_2576	c.1620_1622delACA	c.(1618-1623)cag>ca	p.QQ548del		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	548	Poly-Gln.						binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						ttgctgttgctgttgctgctgct	0.655			T	ETV6	"""AML, meningioma"""								3	3	---	---	---	---					
MCHR1	2847	broad.mit.edu	37	22	41077634	41077634	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chr22:41077634delC	ENST00000249016.4	+	2	1667	c.971delC	c.(970-972)acfs	p.T324fs	MCHR1_ENST00000381433.2_Frame_Shift_Del_p.T198fs|MCHR1_ENST00000498400.1_3'UTR	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	324					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						AAGAGGGTGACCCGCACAGCC	0.627													7	22	---	---	---	---					
PIM2	11040	broad.mit.edu	37	X	48772296	48772296	+	Splice_Site	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:48772296delC	ENST00000376509.4	-	4	785		c.e4+1			NM_006875.3	NP_006866.2	Q9P1W9	PIM2_HUMAN	pim-2 oncogene						anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						AGAAGCCTTACCATCAAAGTC	0.488													8	29	---	---	---	---					
PCDH19	57526	broad.mit.edu	37	X	99657667	99657667	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7039-01A-11D-1945-08	TCGA-95-7039-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d834605-102b-4b3a-a2fa-b26525c77acf	fd2074ee-309f-48f9-a122-92a5bb8ee1f2	g.chrX:99657667delC	ENST00000373034.4	-	3	4146	c.2471delG	c.(2470-2472)gcfs	p.G824fs	PCDH19_ENST00000420881.2_Frame_Shift_Del_p.G777fs|PCDH19_ENST00000255531.7_Frame_Shift_Del_p.G777fs	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	824					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GCGGCGGCAGCCCAGGGGCAG	0.547													11	8	---	---	---	---					
