Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NAV2	89797	broad.mit.edu	37	11	20129313	20129313	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:20129313C>T	ENST00000396085.1	+	37	7315	c.6954C>T	c.(6952-6954)gtC>gtT	p.V2318V	NAV2_ENST00000349880.4_Silent_p.V2315V|NAV2_ENST00000396087.3_Silent_p.V2374V|NAV2_ENST00000527559.2_Silent_p.V2303V|NAV2_ENST00000311043.8_Silent_p.V1379V|NAV2_ENST00000533917.1_Silent_p.V1379V|NAV2_ENST00000360655.4_Silent_p.V2251V|NAV2_ENST00000540292.1_Silent_p.V2305V	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2374						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TGGAAGCCGTCAGAGAAGGAC	0.552000													63	117					0	0	0.048971	0	0
EDNRB	1910	broad.mit.edu	37	13	78477365	78477365	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:78477365T>C	ENST00000377211.4	-	4	1149	c.997A>G	c.(997-999)Att>Gtt	p.I333V	EDNRB_ENST00000334286.5_Missense_Mutation_p.I243V|EDNRB_ENST00000446573.1_Missense_Mutation_p.I243V	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	243					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TCCATCGTAATTATATCAAAA	0.398000													51	100					0	0	0.048971	0	0
TARBP1	6894	broad.mit.edu	37	1	234546274	234546274	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:234546274C>T	ENST00000040877.1	-	23	3708	c.3709G>A	c.(3709-3711)Gaa>Aaa	p.E1237K		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1237					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AGATTTTCTTCACCCTGAAAA	0.348000													9	44					0	0	0.047766	0	0
TRAF5	7188	broad.mit.edu	37	1	211529722	211529722	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:211529722A>G	ENST00000261464.5	+	4	344	c.290A>G	c.(289-291)aAt>aGt	p.N97S	TRAF5_ENST00000427925.2_Missense_Mutation_p.N97S|TRAF5_ENST00000336184.2_Missense_Mutation_p.N97S|TRAF5_ENST00000367004.3_Missense_Mutation_p.N97S|TRAF5_ENST00000462410.1_3'UTR	NM_001033910.2	NP_001029082.1	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	97					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TTTAAAGACAATTGTTGCAAA	0.358000													34	50					0	0	0.064281	0	0
COL4A3	1285	broad.mit.edu	37	2	228118844	228118844	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:228118844A>G	ENST00000396578.3	+	14	944	c.782A>G	c.(781-783)aAg>aGg	p.K261R	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000437673.1_RNA|AC097662.2_ENST00000606119.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	261	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAGGGGGAAAAGGGAGACAAG	0.433000													3	92					0	0	0.021553	0	0
CD70	970	broad.mit.edu	37	19	6590912	6590912	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:6590912G>C	ENST00000245903.3	-	1	251	c.102C>G	c.(100-102)ctC>ctG	p.L34L	CD70_ENST00000423145.3_Silent_p.L34L	NM_001252.3	NP_001243.1	P32970	CD70_HUMAN	CD70 molecule	34					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|skin(1)	11						TGCACACCACGAGGCAGATCA	0.622000													25	83					0	0	0.027356	0	0
GPATCH2L	55668	broad.mit.edu	37	14	76638254	76638254	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:76638254C>T	ENST00000261530.7	+	4	862	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L	GPATCH2L_ENST00000312858.5_Silent_p.L266L|GPATCH2L_ENST00000557263.1_Silent_p.L266L|GPATCH2L_ENST00000556663.1_Silent_p.L266L	NM_017926.2	NP_060396.2			G patch domain containing 2-like																		CCCTAATCTTCTGCCCAAGTG	0.413000													50	104					0	0	0.048971	0	0
C15orf60	283677	broad.mit.edu	37	15	73852120	73852120	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:73852120C>T	ENST00000331090.6	+	6	692	c.664C>T	c.(664-666)Cat>Tat	p.H222Y	C15orf60_ENST00000560581.1_Missense_Mutation_p.H194Y	NM_001042367.1	NP_001035826.1	Q7Z4M0	CO060_HUMAN	chromosome 15 open reading frame 60	222										endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|pancreas(1)|prostate(2)	17						GGAGCTGCCCCATGTCTATGA	0.468000													27	61					0	0	0.027356	0	0
ACSM5	54988	broad.mit.edu	37	16	20435296	20435296	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:20435296G>T	ENST00000331849.4	+	6	973	c.826G>T	c.(826-828)Gtg>Ttg	p.V276L		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	276					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CACTGGCTGGGTGAAGGCAGC	0.502000													88	91					3.01496e-42	4.02762e-42	0.048971	1	0
MYH2	4620	broad.mit.edu	37	17	10428230	10428230	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:10428230G>C	ENST00000245503.5	-	34	5199	c.4815C>G	c.(4813-4815)agC>agG	p.S1605R	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.S1605R	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1605					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CATCCAGCGTGCTCTGCATGG	0.453000													47	47					0	0	0.048971	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98380131	98380131	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:98380131G>A	ENST00000339364.5	-	12	2038	c.1919C>T	c.(1918-1920)tCg>tTg	p.S640L	PIK3AP1_ENST00000371109.3_Missense_Mutation_p.S239L|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.S462L	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	640						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AAAGGACTCCGATCGTTTCTT	0.512000													72	127					0	0	0.048971	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427669	25427669	+	RNA	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:25427669C>A	ENST00000424208.1	+	0	272					NR_003305.1																						CCCAGGAGGGCCCCTGTATTT	0.557000													30	78					5.77227e-19	7.16417e-19	0.037714	1	0
C10orf137	26098	broad.mit.edu	37	10	127414318	127414318	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:127414318G>C	ENST00000337623.3	+	6	808	c.703G>C	c.(703-705)Gat>Cat	p.D235H	C10orf137_ENST00000356792.4_Missense_Mutation_p.D235H	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GTCCAGTTCAGATCAGACAAA	0.483000													13	31					0	0	0.013537	0	0
MRPL22	29093	broad.mit.edu	37	5	154346452	154346452	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:154346452C>G	ENST00000523037.1	+	7	657	c.616C>G	c.(616-618)Cta>Gta	p.L206V	MRPL22_ENST00000439747.3_Missense_Mutation_p.L232V|MRPL22_ENST00000522038.1_Missense_Mutation_p.L212V|MRPL22_ENST00000265229.8_Missense_Mutation_p.L126V|MRPL22_ENST00000518364.1_3'UTR	NM_014180.3	NP_054899.2	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22	206					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGTTCACACTCTATGATGAGG	0.433000													4	4					0	0	0.014758	0	0
COL11A1	1301	broad.mit.edu	37	1	103404613	103404613	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:103404613C>T	ENST00000358392.2	-	44	3769	c.3452G>A	c.(3451-3453)aGc>aAc	p.S1151N	COL11A1_ENST00000512756.1_Missense_Mutation_p.S1023N|COL11A1_ENST00000370096.3_Missense_Mutation_p.S1139N|COL11A1_ENST00000353414.4_Missense_Mutation_p.S1100N	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1139	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCACCCTTGCTGCCTTTTTG	0.328000													40	85					0	0	0.048971	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12252977	12252977	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:12252977G>T	ENST00000376259.3	+	6	698	c.609G>T	c.(607-609)acG>acT	p.T203T	TNFRSF1B_ENST00000492361.1_3'UTR	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	203					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GCACGTCCACGTCCCCCACCC	0.622000													16	44					6.44725e-10	7.25575e-10	0.069288	1	0
SLC35G3	146861	broad.mit.edu	37	17	33520613	33520613	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:33520613G>T	ENST00000297307.5	-	1	799	c.714C>A	c.(712-714)ctC>ctA	p.L238L		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	238						integral to membrane											GCAGCACAAAGAGGCCTGGCA	0.612000													26	67					2.12542e-12	2.45106e-12	0.030593	1	0
CNTN1	1272	broad.mit.edu	37	12	41353010	41353010	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:41353010C>T	ENST00000551295.2	+	15	1895	c.1778C>T	c.(1777-1779)tCa>tTa	p.S593L	CNTN1_ENST00000347616.1_Missense_Mutation_p.S593L|CNTN1_ENST00000547849.1_Missense_Mutation_p.S593L|CNTN1_ENST00000547702.1_Missense_Mutation_p.S593L|CNTN1_ENST00000348761.2_Missense_Mutation_p.S582L|CNTN1_ENST00000360099.3_Missense_Mutation_p.S593L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	593	Ig-like C2-type 6.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GACAATTCTTCAGCTTCAGCT	0.383000													16	36					0	0	0.033300	0	0
A1CF	29974	broad.mit.edu	37	10	52575818	52575818	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:52575818G>C	ENST00000395489.2	-	11	1464	c.1068C>G	c.(1066-1068)gcC>gcG	p.A356A	ASAH2B_ENST00000483649.1_3'UTR|A1CF_ENST00000373993.1_Silent_p.A363A|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000374001.1_Silent_p.A363A|A1CF_ENST00000395495.1_Silent_p.A308A|A1CF_ENST00000373997.3_Silent_p.A363A|A1CF_ENST00000282641.2_Silent_p.A363A|A1CF_ENST00000373995.3_Silent_p.A371A	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	363					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GTCCTTTGGTGGCTGGGAAAT	0.483000													17	51					0	0	0.049695	0	0
SLC44A3	126969	broad.mit.edu	37	1	95290143	95290143	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:95290143C>A	ENST00000271227.6	+	3	332	c.230C>A	c.(229-231)tCc>tAc	p.S77Y	SLC44A3_ENST00000467909.1_Missense_Mutation_p.S29Y|SLC44A3_ENST00000527077.1_Missense_Mutation_p.S41Y|SLC44A3_ENST00000532427.1_Missense_Mutation_p.S29Y|SLC44A3_ENST00000529450.1_Missense_Mutation_p.S77Y|SLC44A3_ENST00000446120.2_Missense_Mutation_p.S41Y	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	77						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	AAGAAGAACTCCCCCGTGGAA	0.507000													34	89					3.38236e-24	4.28922e-24	0.027894	1	0
EIF1AX	1964	broad.mit.edu	37	X	20153879	20153879	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:20153879T>G	ENST00000379607.5	-	3	384	c.181A>C	c.(181-183)Atc>Ctc	p.I61L	EIF1AX_ENST00000379593.1_Missense_Mutation_p.I33L	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	61	S1-like.					cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TTTCCTCTGATGTGACATAAC	0.378000													45	25					0	0	0.048971	0	0
COL22A1	169044	broad.mit.edu	37	8	139839014	139839014	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:139839014G>A	ENST00000303045.6	-	6	1302	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S	COL22A1_ENST00000435777.1_Missense_Mutation_p.P286S	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	286	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AAACCTTGGGGGAACACATCC	0.522000										HNSCC(7;0.00092)			12	29					0	0	0.010729	0	0
CALCR	799	broad.mit.edu	37	7	93067425	93067425	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:93067425C>G	ENST00000359558.2	-	13	1278	c.979G>C	c.(979-981)Gtg>Ctg	p.V327L	CALCR_ENST00000394441.1_Missense_Mutation_p.V293L|CALCR_ENST00000421592.1_Missense_Mutation_p.V309L|CALCR_ENST00000426151.1_Missense_Mutation_p.V293L|CALCR_ENST00000360249.4_Missense_Mutation_p.V309L	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	309					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGGGTTTCCACACTCAGCCAG	0.348000													14	60					0	0	0.055883	0	0
LIPH	200879	broad.mit.edu	37	3	185245369	185245369	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:185245369G>C	ENST00000296252.4	-	4	672	c.531C>G	c.(529-531)ctC>ctG	p.L177L	LIPH_ENST00000424591.2_Intron	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	177			Missing (in LAH2).		lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CTGCAGGGTCGAGGCCTGGAA	0.547000													40	34					0	0	0.027894	0	0
ACSM4	341392	broad.mit.edu	37	12	7480967	7480967	+	Nonstop_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:7480967T>C	ENST00000399422.4	+	13	1789	c.1741T>C	c.(1741-1743)Tag>Cag	p.*581Q		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	0					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GAGAGGAAGATAGTTTGATAA	0.348000													5	8					0	0	0.021553	0	0
BRINP2	57795	broad.mit.edu	37	1	177199193	177199193	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:177199193G>T	ENST00000361539.4	+	2	493	c.181G>T	c.(181-183)Gac>Tac	p.D61Y		NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		61						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GCTGCTCACAGACCGGGGCCC	0.642000													31	82					4.11147e-13	4.76495e-13	0.064281	1	0
C11orf74	119710	broad.mit.edu	37	11	36657643	36657643	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:36657643G>T	ENST00000446510.2	+	4	433	c.334G>T	c.(334-336)Gag>Tag	p.E112*	C11orf74_ENST00000534635.1_Intron|C11orf74_ENST00000334307.5_Nonsense_Mutation_p.E112*|C11orf74_ENST00000347206.4_Intron			Q86VG3	CK074_HUMAN	chromosome 11 open reading frame 74	112										breast(1)|kidney(1)|large_intestine(1)|lung(5)	8	all_lung(20;0.226)	all_hematologic(20;0.0118)				CATGGATGAAGAGATTAAACC	0.328000													15	20					3.99206e-14	4.6574e-14	0.043863	1	0
ALDH8A1	64577	broad.mit.edu	37	6	135263570	135263570	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:135263570G>A	ENST00000265605.2	-	3	487	c.419C>T	c.(418-420)aCg>aTg	p.T140M	RP11-349J5.2_ENST00000416448.2_RNA|ALDH8A1_ENST00000367847.2_Missense_Mutation_p.T140M|ALDH8A1_ENST00000367845.2_Missense_Mutation_p.T140M	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	140					retinal metabolic process	cytoplasm	retinal dehydrogenase activity	p.T140M(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		GGCCCGCACCGTGTAGTGCAT	0.582000													30	68					0	0	0.054565	0	0
ZNF223	7766	broad.mit.edu	37	19	44570323	44570323	+	Silent	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:44570323T>C	ENST00000591793.1	+	7	755	c.672T>C	c.(670-672)ccT>ccC	p.P224P	ZNF223_ENST00000434772.3_Silent_p.P114P			Q9UK11	ZN223_HUMAN	zinc finger protein 223	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				TAACCAGGCCTCAAGACTCTA	0.473000													12	41					0	0	0.013537	0	0
IGSF8	93185	broad.mit.edu	37	1	160064708	160064708	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:160064708G>A	ENST00000368086.1	-	2	609	c.393C>T	c.(391-393)tcC>tcT	p.S131S	IGSF8_ENST00000314485.7_Silent_p.S131S|IGSF8_ENST00000460351.1_5'UTR			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	131	Ig-like C2-type 1.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGGTATCAGTGGAGGGGGTGT	0.632000													20	73					0	0	0.076483	0	0
OR2B6	26212	broad.mit.edu	37	6	27925535	27925535	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:27925535G>T	ENST00000244623.1	+	1	517	c.517G>T	c.(517-519)Gtg>Ttg	p.V173L		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGACCCCTATGTGATAGATCA	0.483000													49	90					7.50695e-29	9.71325e-29	0.048971	1	0
MAP3K12	7786	broad.mit.edu	37	12	53875980	53875980	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:53875980C>G	ENST00000267079.2	-	14	2451	c.2226G>C	c.(2224-2226)ctG>ctC	p.L742L	MAP3K12_ENST00000547488.1_Silent_p.L775L|MAP3K12_ENST00000547035.1_Silent_p.L775L	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	742					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						GGCGCATGTTCAGGCTCTGAG	0.498000											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	126					0	0	0.048971	0	0
UPF1	5976	broad.mit.edu	37	19	18974407	18974407	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:18974407A>G	ENST00000262803.5	+	19	3033	c.2761A>G	c.(2761-2763)Aac>Gac	p.N921D	UPF1_ENST00000599848.1_Missense_Mutation_p.N932D	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	932					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						GAAGCTGGTCAACACTATCAA	0.607000													8	13					0	0	0.047766	0	0
CCNE1	898	broad.mit.edu	37	19	30313407	30313407	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:30313407T>C	ENST00000262643.3	+	11	1286	c.1007T>C	c.(1006-1008)aTg>aCg	p.M336T	CCNE1_ENST00000444983.2_Missense_Mutation_p.M321T|CCNE1_ENST00000357943.5_Missense_Mutation_p.M293T	NM_001238.2	NP_001229.1	P24864	CCNE1_HUMAN	cyclin E1	336					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			CCATTTGCCATGGTTATAAGG	0.498000			A		serous ovarian								58	103					0	0	0.048971	0	0
KLHL5	51088	broad.mit.edu	37	4	39077583	39077583	+	Splice_Site	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:39077583A>G	ENST00000261425.3	+	3	535		c.e3-1		KLHL5_ENST00000381930.3_Splice_Site|KLHL5_ENST00000359687.2_Splice_Site|KLHL5_ENST00000504108.1_Splice_Site|KLHL5_ENST00000261426.5_Intron|KLHL5_ENST00000508137.2_Splice_Site	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5							cytoplasm|cytoskeleton	actin binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						TTTTCTTTTCAGGACTTCCAA	0.323000													18	52					0	0	0.076483	0	0
CDX4	1046	broad.mit.edu	37	X	72667226	72667226	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:72667226C>A	ENST00000373514.2	+	1	137	c.137C>A	c.(136-138)gCg>gAg	p.A46E		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	46						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					AATTTCGCTGCGGCACCGGCT	0.647000													11	5					0.00244969	0.00251435	0.020292	1	0
FAT3	120114	broad.mit.edu	37	11	92430571	92430571	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:92430571G>T	ENST00000298047.6	+	3	3646	c.3629G>T	c.(3628-3630)aGg>aTg	p.R1210M	FAT3_ENST00000409404.2_Missense_Mutation_p.R1210M|FAT3_ENST00000525166.1_Missense_Mutation_p.R1060M			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1210	Cadherin 11.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAACTTCAAGGAAATTGGAT	0.383000										TCGA Ovarian(4;0.039)			5	48					0.0293803	0.0298061	0.029380	1	0
C10orf68	79741	broad.mit.edu	37	10	33137593	33137593	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:33137593C>T	ENST00000375030.2	+	20	2066	c.1448C>T	c.(1447-1449)aCa>aTa	p.T483I	C10orf68_ENST00000375028.3_Missense_Mutation_p.T528I|C10orf68_ENST00000375025.4_Missense_Mutation_p.T588I			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	524										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						AGGAGCATTACACCAAGTAAA	0.279000													11	50					0	0	0.010729	0	0
C2CD3	26005	broad.mit.edu	37	11	73801966	73801966	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:73801966C>A	ENST00000334126.7	-	20	3759	c.3533G>T	c.(3532-3534)gGc>gTc	p.G1178V	C2CD3_ENST00000313663.7_Missense_Mutation_p.G1178V			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1178	C2 1.					centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GTACCTTAGGCCCACATCCAG	0.488000													12	26					1.5842e-08	1.75743e-08	0.016723	1	0
GALR1	2587	broad.mit.edu	37	18	74962762	74962762	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:74962762C>G	ENST00000299727.3	+	1	258	c.258C>G	c.(256-258)ctC>ctG	p.L86L		NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	86					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity	p.L86L(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CCTACCTGCTCTTCTGCATCC	0.622000													61	48					0	0	0.048971	0	0
OR5T2	219464	broad.mit.edu	37	11	55999647	55999647	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55999647A>T	ENST00000313264.4	-	1	1090	c.1015T>A	c.(1015-1017)Tca>Aca	p.S339T		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	339					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TTTTTCATTGAGTCTTTTACA	0.333000													25	45					0	0	0.024334	0	0
CMYA5	202333	broad.mit.edu	37	5	79084793	79084793	+	Splice_Site	SNP	G	G	C	rs57346823		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:79084793G>C	ENST00000446378.2	+	10	11586		c.e10-1		CTC-431G16.2_ENST00000421252.2_RNA	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5							perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTTGTATTTAGATCTTTCTCT	0.333000													19	13					0	0	0.055883	0	0
GRAMD4	23151	broad.mit.edu	37	22	47022849	47022849	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:47022849G>C	ENST00000406902.1	+	2	366	c.153G>C	c.(151-153)ctG>ctC	p.L51L	GRAMD4_ENST00000361034.3_Silent_p.L51L|GRAMD4_ENST00000490378.1_Intron			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	51					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GCGAGGAGCTGAGGGACCCTG	0.652000													6	84					0	0	0.021553	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917367	48917367	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:48917367G>A	ENST00000311378.4	+	2	1246	c.718G>A	c.(718-720)Gag>Aag	p.E240K	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.E147K	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	240	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCCCCGGCCTGAGATCACCTG	0.622000													32	63					0	0	0.080422	0	0
DZIP3	9666	broad.mit.edu	37	3	108355516	108355516	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:108355516G>T	ENST00000361582.3	+	11	1202	c.972G>T	c.(970-972)agG>agT	p.R324S	DZIP3_ENST00000463306.1_Missense_Mutation_p.R324S	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	324					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						ACATGGTAAGGATGCTGCAAT	0.284000													46	143					6.70656e-16	8.03868e-16	0.048971	1	0
PRKRIP1	79706	broad.mit.edu	37	7	102047917	102047917	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:102047917G>A	ENST00000496391.1	+	9	1739	c.429G>A	c.(427-429)aaG>aaA	p.K143K	PRKRIP1_ENST00000397912.3_Silent_p.K143K|PRKRIP1_ENST00000462601.1_Silent_p.K86K|PRKRIP1_ENST00000354783.4_Intron|PRKRIP1_ENST00000482465.1_3'UTR			Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	143	Required for RNA-binding (By similarity).					nucleolus				endometrium(1)|lung(4)|ovary(1)	6						TGGCAAAGAAGATGAAACTTG	0.348000													12	48					0	0	0.020292	0	0
SPTLC1	10558	broad.mit.edu	37	9	94874764	94874764	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:94874764T>G	ENST00000262554.2	-	2	143	c.138A>C	c.(136-138)ttA>ttC	p.L46F	SPTLC1_ENST00000482632.1_5'UTR|SPTLC1_ENST00000337841.4_Missense_Mutation_p.L46F	NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	46						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ATCGTTCTTGTAATTTGTAAG	0.348000													18	96					0	0	0.069288	0	0
EGFR	1956	broad.mit.edu	37	7	55211028	55211028	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:55211028A>G	ENST00000275493.2	+	3	448	c.271A>G	c.(271-273)Att>Gtt	p.I91V	EGFR_ENST00000455089.1_Missense_Mutation_p.I91V|EGFR_ENST00000442591.1_Missense_Mutation_p.I91V|EGFR_ENST00000342916.3_Missense_Mutation_p.I91V|EGFR_ENST00000344576.2_Missense_Mutation_p.I91V|EGFR_ENST00000454757.2_Missense_Mutation_p.I38V|EGFR_ENST00000420316.2_Missense_Mutation_p.I91V	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	91					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.I91L(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTATGTCCTCATTGCCCTCAA	0.413000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			36	95					0	0	0.027894	0	0
PDCL2	132954	broad.mit.edu	37	4	56448305	56448305	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:56448305G>T	ENST00000295645.4	-	2	208	c.106C>A	c.(106-108)Cgt>Agt	p.R36S		NM_152401.2	NP_689614.2	Q8N4E4	PDCL2_HUMAN	phosducin-like 2	36								p.R36C(1)		endometrium(1)|kidney(1)|lung(4)|ovary(1)	7	Lung NSC(11;0.00256)|Glioma(25;0.08)|all_epithelial(27;0.0863)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.69e-07)|Lung(4;1.03e-06)|Epithelial(7;0.00669)			TTCTGTAAACGTAAAACCATT	0.363000													8	40					0.00307968	0.00315633	0.038147	1	0
OR51F1	256892	broad.mit.edu	37	11	4790238	4790238	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:4790238C>A	ENST00000380383.1	-	1	930	c.931G>T	c.(931-933)Gct>Tct	p.A311S	MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.A304S|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	304						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTGAGCATAGCCTTGCGGATT	0.428000													26	76					5.45727e-16	6.56373e-16	0.037714	1	0
AKAP6	9472	broad.mit.edu	37	14	33290675	33290675	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:33290675G>A	ENST00000280979.4	+	13	3826	c.3656G>A	c.(3655-3657)tGg>tAg	p.W1219*	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1219					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCCCTGGAATGGGATGAAATG	0.403000													25	63					0	0	0.027356	0	0
SMG1	23049	broad.mit.edu	37	16	18826800	18826800	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:18826800G>T	ENST00000446231.2	-	59	10888	c.10476C>A	c.(10474-10476)atC>atA	p.I3492I	SMG1_ENST00000389467.3_Silent_p.I3493I			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3492					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.I3492M(1)|p.I3488M(1)		NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AGGTGGGAGTGATTTCCTGGA	0.373000													6	110					3.59834e-05	3.79343e-05	0.021553	1	0
TMEM260	54916	broad.mit.edu	37	14	57082682	57082682	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:57082682G>C	ENST00000261556.6	+	8	1000	c.878G>C	c.(877-879)aGg>aCg	p.R293T	TMEM260_ENST00000553335.1_3'UTR|TMEM260_ENST00000536419.1_5'UTR|TMEM260_ENST00000538838.1_Missense_Mutation_p.R293T	NM_017799.3	NP_060269.3			transmembrane protein 260																		ACAAATATGAGGACCGAACTC	0.313000													42	79					0	0	0.048971	0	0
SDPR	8436	broad.mit.edu	37	2	192701335	192701335	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:192701335G>A	ENST00000304141.4	-	2	921	c.592C>T	c.(592-594)Cac>Tac	p.H198Y		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	198						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCCACGGTGTGCAGGGTTTCC	0.547000													14	38					0	0	0.038395	0	0
CDH9	1007	broad.mit.edu	37	5	26988330	26988330	+	Silent	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:26988330T>A	ENST00000231021.4	-	2	283	c.111A>T	c.(109-111)atA>atT	p.I37I		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	37					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TCAGACCCGCTATCTTTTTGC	0.393000													20	66					0	0	0.049695	0	0
TFB1M	51106	broad.mit.edu	37	6	155606413	155606413	+	Splice_Site	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:155606413T>C	ENST00000367166.4	-	5	602		c.e5-2			NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TGCAAGTCTCTAGAGAGAGAC	0.398000													11	21					0	0	0.069234	0	0
TPPP2	122664	broad.mit.edu	37	14	21499323	21499323	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:21499323C>T	ENST00000460647.2	+	3	450	c.326C>T	c.(325-327)aCt>aTt	p.T109I	TPPP2_ENST00000321760.6_Splice_Site_p.T109_splice|TPPP2_ENST00000530140.2_Splice_Site_p.T109_splice|NDRG2_ENST00000403829.3_Intron			P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family member 2	109						cytoplasm				endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACTGGCGCTACTGTGAGTGAC	0.532000													26	56					0	0	0.050027	0	0
CARD11	84433	broad.mit.edu	37	7	2954905	2954905	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:2954905C>G	ENST00000396946.4	-	21	3208	c.2805G>C	c.(2803-2805)ctG>ctC	p.L935L		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	935					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TGGTGGCGTCCAGCGAGGACC	0.627000			Mis		DLBCL								72	43					0	0	0.048971	0	0
LEFTY1	10637	broad.mit.edu	37	1	226076613	226076613	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:226076613C>A	ENST00000272134.5	-	1	233	c.154G>T	c.(154-156)Gtc>Ttc	p.V52F	LEFTY1_ENST00000492457.1_Intron|RP4-559A3.7_ENST00000432920.2_Intron	NM_020997.3	NP_066277.1	O75610	LFTY1_HUMAN	left-right determination factor 1	52					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					GTGGGGATGACCAGCTCCTCC	0.701000													4	33					1.23904e-05	1.31016e-05	0.014758	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103153800	103153800	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:103153800G>A	ENST00000375735.2	+	73	11020	c.10876G>A	c.(10876-10878)Gtg>Atg	p.V3626M	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.V3633M|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3626					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AAGCTGGGCCGTGGCAACATT	0.353000													9	24					0	0	0.069234	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37947399	37947399	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:37947399G>A	ENST00000373087.6	+	4	897	c.781G>A	c.(781-783)Gag>Aag	p.E261K		NM_025079.2	NP_079355.2	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	261					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCGCTTCATCGAGGAGCGGCT	0.572000													14	22					0	0	0.024245	0	0
TBC1D9	23158	broad.mit.edu	37	4	141578791	141578791	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:141578791G>A	ENST00000442267.2	-	12	2171	c.2097C>T	c.(2095-2097)ttC>ttT	p.F699F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	699	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTCCTTCATAGAAGAAACAGT	0.473000													45	44					0	0	0.048971	0	0
OR4A5	81318	broad.mit.edu	37	11	51412202	51412202	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:51412202G>T	ENST00000319760.6	-	1	246	c.194C>A	c.(193-195)tCa>tAa	p.S65*		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				ATCTATAAATGACAGGCAGGC	0.443000													17	52					4.63292e-17	5.64008e-17	0.049695	1	0
VRK3	51231	broad.mit.edu	37	19	50498136	50498136	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:50498136C>A	ENST00000599538.1	-	9	1469	c.805G>T	c.(805-807)Gcc>Tcc	p.A269S	VRK3_ENST00000593919.1_Missense_Mutation_p.A269S|VRK3_ENST00000316763.3_Missense_Mutation_p.A269S|VRK3_ENST00000594948.1_Missense_Mutation_p.A269S|VRK3_ENST00000601912.1_Missense_Mutation_p.A219S|VRK3_ENST00000594092.1_Missense_Mutation_p.A269S|VRK3_ENST00000377011.2_Missense_Mutation_p.A219S|VRK3_ENST00000601341.1_Missense_Mutation_p.A219S|VRK3_ENST00000443401.2_Missense_Mutation_p.A38S|VRK3_ENST00000424804.2_5'UTR			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	269	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		ACATCCAGGGCCGACTGAAGG	0.622000													20	49					1.10513e-12	1.27867e-12	0.069288	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090711	238090711	+	RNA	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:238090711C>A	ENST00000450451.1	+	0	2217					NR_027247.2																						TCATGAAGATCCTCACCGAGC	0.607000													7	10					0.000157383	0.000164676	0.038147	1	0
KCNK13	56659	broad.mit.edu	37	14	90650453	90650453	+	Splice_Site	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:90650453A>G	ENST00000282146.4	+	2	775		c.e2-1			NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13							integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TCTCTCCTGCAGGGTTTGGGA	0.458000													24	55					0	0	0.024334	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68220796	68220796	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:68220796C>T	ENST00000347230.4	-	38	7258	c.7120G>A	c.(7120-7122)Gcc>Acc	p.A2374T	ZFYVE26_ENST00000557306.1_Missense_Mutation_p.A220T	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2374					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		ACCTTGCAGGCAACATCCATT	0.438000													49	160					0	0	0.048971	0	0
RNGTT	8732	broad.mit.edu	37	6	89388103	89388103	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:89388103C>T	ENST00000369485.4	-	14	1661	c.1475G>A	c.(1474-1476)gGa>gAa	p.G492E	RNGTT_ENST00000265607.6_Missense_Mutation_p.G469E|RNGTT_ENST00000369475.3_Missense_Mutation_p.G492E|RNGTT_ENST00000538899.1_Missense_Mutation_p.G409E	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	492	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TTCATAACCTCCAACATACAG	0.328000													20	41					0	0	0.024334	0	0
MACROD2	140733	broad.mit.edu	37	20	14665577	14665577	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:14665577C>G	ENST00000217246.4	+	5	785	c.390C>G	c.(388-390)atC>atG	p.I130M	MACROD2_ENST00000310348.4_Missense_Mutation_p.I130M|MACROD2_ENST00000464883.1_3'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	130	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGCAAAAATCACATGTGGCT	0.428000													44	85					0	0	0.048971	0	0
PCGF2	7703	broad.mit.edu	37	17	36895085	36895085	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:36895085C>T	ENST00000580830.1	-	8	1047	c.346G>A	c.(346-348)Gag>Aag	p.E116K	PCGF2_ENST00000360797.2_Missense_Mutation_p.E116K|PCGF2_ENST00000585100.1_Missense_Mutation_p.E116K|PCGF2_ENST00000578109.1_Missense_Mutation_p.E62K|PCGF2_ENST00000579882.1_Missense_Mutation_p.E116K|PCGF2_ENST00000581345.1_Missense_Mutation_p.E116K			P35227	PCGF2_HUMAN	polycomb group ring finger 2	116					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					TCCAAGACCTCGCCGCGGTCC	0.597000													33	239					0	0	0.025465	0	0
RELN	5649	broad.mit.edu	37	7	103368615	103368615	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:103368615G>A	ENST00000424685.2	-	7	855	c.696C>T	c.(694-696)ggC>ggT	p.G232G	RELN_ENST00000428762.1_Silent_p.G232G|RELN_ENST00000343529.5_Silent_p.G232G			P78509	RELN_HUMAN	reelin	232					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCATAATCGCGCCACACTGTT	0.448000													50	67					0	0	0.048971	0	0
EVX2	344191	broad.mit.edu	37	2	176948242	176948242	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:176948242A>G	ENST00000308618.4	-	1	399	c.263T>C	c.(262-264)gTc>gCc	p.V88A		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	88						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		TTCGGAGGAGACGGTGCTTTC	0.627000													19	59					0	0	0.062417	0	0
FAM169A	26049	broad.mit.edu	37	5	74109750	74109750	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:74109750C>G	ENST00000389156.4	-	6	675	c.585G>C	c.(583-585)ggG>ggC	p.G195G	FAM169A_ENST00000380515.3_3'UTR|FAM169A_ENST00000510496.1_Intron	NM_015566.2	NP_056381.1	Q9Y6X4	F169A_HUMAN	family with sequence similarity 169, member A	195										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	27						GCATGTGAAGCCCAAAATCTT	0.408000													4	78					0	0	0.014758	0	0
TNR	7143	broad.mit.edu	37	1	175332847	175332847	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:175332847G>T	ENST00000367674.1	-	13	3412	c.2704C>A	c.(2704-2706)Caa>Aaa	p.Q902K	TNR_ENST00000263525.2_Missense_Mutation_p.Q902K	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	902	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TTGTTACCTTGGGTGGGTCGA	0.453000													52	125					4.60343e-24	5.82713e-24	0.048971	1	0
CCDC19	25790	broad.mit.edu	37	1	159850455	159850455	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:159850455C>A	ENST00000426543.2	-	8	1133	c.678G>T	c.(676-678)atG>atT	p.M226I	CCDC19_ENST00000368099.4_Missense_Mutation_p.M311I|CCDC19_ENST00000476696.1_5'UTR			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	311						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TCTCAGCTTGCATCTTCAGTT	0.473000													13	57					1.05317e-09	1.18334e-09	0.020292	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118386379	118386379	+	RNA	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:118386379T>A	ENST00000537242.1	+	0	361				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		CCCCAGAAAATGTTTGAAGTG	0.522000													10	12					0	0	0.016723	0	0
GRB10	2887	broad.mit.edu	37	7	50671734	50671734	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:50671734T>A	ENST00000403097.1	-	16	2267	c.1487A>T	c.(1486-1488)gAa>gTa	p.E496V	GRB10_ENST00000398810.2_Missense_Mutation_p.E444V|GRB10_ENST00000357271.5_Missense_Mutation_p.E456V|GRB10_ENST00000439599.1_Missense_Mutation_p.E496V|GRB10_ENST00000335866.3_Missense_Mutation_p.E444V|GRB10_ENST00000401949.1_Missense_Mutation_p.E502V|GRB10_ENST00000402578.1_Missense_Mutation_p.E444V|GRB10_ENST00000402497.1_Missense_Mutation_p.E444V|GRB10_ENST00000407526.1_Missense_Mutation_p.E444V|GRB10_ENST00000406641.1_Missense_Mutation_p.E444V|GRB10_ENST00000398812.2_Missense_Mutation_p.E502V			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	502	SH2.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CCTGTGGGATTCCTCCCTGGA	0.532000									Russell-Silver syndrome				71	223					0	0	0.048971	0	0
PIF1	80119	broad.mit.edu	37	15	65108962	65108962	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:65108962G>T	ENST00000268043.4	-	12	1771	c.1677C>A	c.(1675-1677)ggC>ggA	p.G559G	PIF1_ENST00000559239.1_Silent_p.G559G|PIF1_ENST00000333425.6_Silent_p.G559G			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	559	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						CCAGGGTCATGCCCTGGGGGA	0.617000													13	34					0.00136819	0.00141259	0.013537	1	0
PAF1	54623	broad.mit.edu	37	19	39876822	39876822	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:39876822C>T	ENST00000221265.3	-	14	1735	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K	PAF1_ENST00000595564.1_Missense_Mutation_p.M397I|PAF1_ENST00000221266.7_Missense_Mutation_p.M374I	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	469					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCTCTGTCCTCATCATCAGAG	0.617000													70	115					0	0	0.048971	0	0
PLCB3	5331	broad.mit.edu	37	11	64033811	64033811	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:64033811C>G	ENST00000540288.1	+	28	3394	c.3291C>G	c.(3289-3291)atC>atG	p.I1097M	PLCB3_ENST00000325234.5_Missense_Mutation_p.I1030M|PLCB3_ENST00000279230.6_Missense_Mutation_p.I1097M	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	1097				REKKELQKILDRKRHNSISEAKMRDKHKKEA -> SWPSWP RSVRSSGRGSPRRSAGACWARCRRG (in Ref. 2; CAA85776).	intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						TGCAGAAGATCCTGGACAGAA	0.587000													10	56					0	0	0.020292	0	0
ERO1L	30001	broad.mit.edu	37	14	53138391	53138391	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:53138391C>A	ENST00000395686.3	-	6	688	c.465G>T	c.(463-465)tgG>tgT	p.W155C		NM_014584.1	NP_055399.1	Q96HE7	ERO1A_HUMAN	ERO1-like (S. cerevisiae)	155					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor		ERO1L/FERMT2(2)	breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12	Breast(41;0.226)					CATGCTTGGTCCACTGAAGAA	0.274000													10	37					3.27435e-08	3.60952e-08	0.020292	1	0
TMEM225	338661	broad.mit.edu	37	11	123753962	123753962	+	Silent	SNP	A	A	G	rs148160664		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:123753962A>G	ENST00000375026.2	-	4	777	c.561T>C	c.(559-561)tcT>tcC	p.S187S		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	187						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TATCTTCGATAGAATTCTCAG	0.433000													8	38					0	0	0.024245	0	0
EPX	8288	broad.mit.edu	37	17	56280473	56280473	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:56280473C>T	ENST00000225371.5	+	11	1850	c.1740C>T	c.(1738-1740)ctC>ctT	p.L580L		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	580					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						TCTGTGGGCTCTCCCAGCCCC	0.522000													37	56					0	0	0.025465	0	0
KEAP1	9817	broad.mit.edu	37	19	10610405	10610405	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:10610405G>A	ENST00000171111.5	-	2	852	c.305C>T	c.(304-306)tCa>tTa	p.S102L	KEAP1_ENST00000393623.2_Missense_Mutation_p.S102L	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	102	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AGGGCTGGATGAGGCCAGCAC	0.627000													16	21					0	0	0.028581	0	0
PAH	5053	broad.mit.edu	37	12	103238149	103238149	+	Missense_Mutation	SNP	C	C	T	rs62508679		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:103238149C>T	ENST00000553106.1	-	10	1502	c.1030G>A	c.(1030-1032)Ggt>Agt	p.G344S	PAH_ENST00000307000.2_Missense_Mutation_p.G339S	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	344			G -> R (in PKU).|G -> V (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AGCCCAGCACCATATGCCTTT	0.438000													10	12					0	0	0.028581	0	0
ITGA2	3673	broad.mit.edu	37	5	52374604	52374604	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:52374604C>G	ENST00000296585.5	+	24	2971	c.2828C>G	c.(2827-2829)tCt>tGt	p.S943C		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	943					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TCCAACAGATCTACCAACATA	0.318000													11	12					0	0	0.013537	0	0
RNF219	79596	broad.mit.edu	37	13	79233246	79233246	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:79233246T>C	ENST00000282003.6	-	1	68	c.10A>G	c.(10-12)Acc>Gcc	p.T4A		NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	4							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TTCTGCACGGTCTGAGCCATG	0.597000													11	18					0	0	0.016723	0	0
TRIM29	23650	broad.mit.edu	37	11	119989012	119989012	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:119989012C>A	ENST00000341846.5	-	7	1967	c.1546G>T	c.(1546-1548)Gtc>Ttc	p.V516F	TRIM29_ENST00000529044.1_Missense_Mutation_p.V255F|TRIM29_ENST00000524816.3_Missense_Mutation_p.V82F|TRIM29_ENST00000528870.1_Missense_Mutation_p.V49F|TRIM29_ENST00000541857.1_Missense_Mutation_p.V249F|TRIM29_ENST00000525887.1_5'UTR	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	516					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TACTCCCAGACCCGGGAGGTG	0.602000													20	29					7.41877e-09	8.25619e-09	0.062417	1	0
GLTSCR1L	23506	broad.mit.edu	37	6	42797548	42797548	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:42797548C>T	ENST00000314073.5	+	6	1653	c.1477C>T	c.(1477-1479)Cag>Tag	p.Q493*	GLTSCR1L_ENST00000394168.1_Nonsense_Mutation_p.Q493*					GLTSCR1-like																		TGCCTCTCCTCAGCTTGTGGG	0.542000													37	94					0	0	0.036044	0	0
ATP10B	23120	broad.mit.edu	37	5	160047577	160047577	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:160047577G>C	ENST00000327245.5	-	15	3039	c.2193C>G	c.(2191-2193)gcC>gcG	p.A731A	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	731					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTAGGCATGGGCAGCGTGCA	0.652000													15	38					0	0	0.038395	0	0
MUC16	94025	broad.mit.edu	37	19	9062050	9062050	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:9062050G>C	ENST00000397910.4	-	3	25599	c.25396C>G	c.(25396-25398)Cag>Gag	p.Q8466E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8468	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGTGAACTGATCAGGCCCT	0.498000													56	142					0	0	0.048971	0	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768547	31768547	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:31768547T>A	ENST00000355459.2	+	1	156	c.143T>A	c.(142-144)cTg>cAg	p.L48Q		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	48	5 X 10 AA approximate repeats.					intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ACGTGCCAGCTGGGTTCCTCT	0.612000													22	59					0	0	0.076483	0	0
DEFB4A	1673	broad.mit.edu	37	8	7752238	7752238	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:7752238A>G	ENST00000302247.2	+	1	88	c.4A>G	c.(4-6)Agg>Ggg	p.R2G		NM_004942.2	NP_004933.1	O15263	DFB4A_HUMAN	defensin, beta 4A	2					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|immune response	extracellular region				lung(1)	1						ATCAGCCATGAGGGTCTTGTA	0.527000													7	112					0	0	0.069234	0	0
KMT2C	58508	broad.mit.edu	37	7	151945009	151945009	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:151945009G>T	ENST00000355193.2	-	14	2728	c.2510C>A	c.(2509-2511)cCt>cAt	p.P837H	KMT2C_ENST00000262189.6_Missense_Mutation_p.P837H					lysine (K)-specific methyltransferase 2C																		AGGTCTACCAGGAGAAAATTT	0.373000													15	207					1.55795e-14	1.8298e-14	0.062417	1	0
USH2A	7399	broad.mit.edu	37	1	216062108	216062108	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:216062108G>T	ENST00000366943.2	-	41	8269	c.7883C>A	c.(7882-7884)cCa>cAa	p.P2628Q	RP5-1111A8.3_ENST00000414995.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.P2628Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2628	Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCTGGACTTGGGATCCCTTC	0.498000										HNSCC(13;0.011)			35	28					6.00712e-18	7.37717e-18	0.050027	1	0
SMC3	9126	broad.mit.edu	37	10	112337194	112337194	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:112337194C>T	ENST00000361804.4	+	5	340	c.214C>T	c.(214-216)Cgt>Tgt	p.R72C	SMC3_ENST00000462899.1_3'UTR	NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	72					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TACTGGTCCTCGTGTTATTTC	0.299000													10	18					0	0	0.016723	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433423	73433423	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:73433423C>A	ENST00000263666.4	-	10	2408	c.2294G>T	c.(2293-2295)cGc>cTc	p.R765L	PDZRN3_ENST00000535920.1_Missense_Mutation_p.R487L|PDZRN3_ENST00000479530.1_Missense_Mutation_p.R482L|PDZRN3_ENST00000466780.1_Missense_Mutation_p.R422L|PDZRN3_ENST00000462146.2_Missense_Mutation_p.R422L	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	765							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CGGGGTGCTGCGGCAGCTCTC	0.647000													9	19					1.08611e-07	1.18608e-07	0.010729	1	0
BPIFB3	359710	broad.mit.edu	37	20	31647283	31647283	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:31647283C>T	ENST00000375494.3	+	3	381	c.381C>T	c.(379-381)tgC>tgT	p.C127C		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	127	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										GCATGCATTGCTCTGGGTGAG	0.602000													7	22					0	0	0.029380	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89918168	89918168	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:89918168C>T	ENST00000548729.1	-	3	452	c.150G>A	c.(148-150)caG>caA	p.Q50Q	POC1B_ENST00000549504.1_Intron|POC1B_ENST00000541909.1_Intron|GALNT4_ENST00000529983.2_Silent_p.Q53Q|POC1B_ENST00000313546.3_Intron|POC1B-GALNT4_ENST00000547474.1_Intron|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000393179.4_Intron|POC1B-GALNT4_ENST00000413530.1_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					CCGTATTTTTCTGGAGGTCTG	0.562000											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	12					0	0	0.069234	0	0
LRP5	4041	broad.mit.edu	37	11	68193529	68193529	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:68193529G>T	ENST00000294304.7	+	16	3617	c.3511G>T	c.(3511-3513)Gac>Tac	p.D1171Y		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1171	Beta-propeller 4.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTACTGGATCGACCGCCAGCA	0.642000													52	124					1.22119e-34	1.62207e-34	0.048971	1	0
GPR124	25960	broad.mit.edu	37	8	37691560	37691560	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:37691560G>A	ENST00000315215.7	+	11	1885	c.1522G>A	c.(1522-1524)Gag>Aag	p.E508K	GPR124_ENST00000412232.2_Missense_Mutation_p.E508K			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	508					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GGCCCAGCGCGAGGACAAGGC	0.662000													46	98					0	0	0.039052	0	0
NR5A2	2494	broad.mit.edu	37	1	200080447	200080447	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:200080447C>A	ENST00000367362.3	+	6	1474	c.1228C>A	c.(1228-1230)Caa>Aaa	p.Q410K	NR5A2_ENST00000236914.3_Missense_Mutation_p.Q364K|NR5A2_ENST00000544748.1_Missense_Mutation_p.Q338K	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	410					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					TACTGGGCAACAAGTGAGTGT	0.423000													11	46					0.010729	0.0109321	0.010729	1	0
KCNB1	3745	broad.mit.edu	37	20	47990541	47990541	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:47990541G>A	ENST00000371741.4	-	2	1722	c.1556C>T	c.(1555-1557)tCt>tTt	p.S519F		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	519	Poly-Ser.				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGAGGACTAGAAGACGATCT	0.468000													181	194					0	0	0.048971	0	0
ZNF157	7712	broad.mit.edu	37	X	47271817	47271817	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:47271817C>G	ENST00000377073.3	+	4	431	c.345C>G	c.(343-345)ctC>ctG	p.L115L		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	115					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						ATAATGCCCTCAGGCATGATA	0.393000													34	20					0	0	0.074837	0	0
MFAP1	4236	broad.mit.edu	37	15	44106739	44106739	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:44106739C>T	ENST00000267812.3	-	4	809	c.577G>A	c.(577-579)Gat>Aat	p.D193N		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	193						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TCCATCTCATCTTCACTGTCT	0.448000													71	128					0	0	0.048971	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453917	84453917	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:84453917C>A	ENST00000377084.2	-	1	2611	c.1726G>T	c.(1726-1728)Gag>Tag	p.E576*		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	576	LRRCT 2.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGGCAGATCTCGTCATTGGAG	0.542000													10	34					6.40141e-05	6.72821e-05	0.010729	1	0
SPATA31D5P	347127	broad.mit.edu	37	9	84534351	84534351	+	RNA	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:84534351C>A	ENST00000527857.1	+	0	4373					NR_026851.1																						TCCCTAAGAACCCTTTTCCTT	0.517000													7	6					3.07112e-06	3.26219e-06	0.010729	1	0
LCMT1	51451	broad.mit.edu	37	16	25175941	25175941	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:25175941G>C	ENST00000399069.3	+	7	747	c.592G>C	c.(592-594)Gaa>Caa	p.E198Q	LCMT1_ENST00000572869.1_3'UTR|LCMT1_ENST00000380966.4_Missense_Mutation_p.E143Q	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	198							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CCTGATAGCTGAATGTGTGCT	0.423000													43	44					0	0	0.039052	0	0
FBXO18	84893	broad.mit.edu	37	10	5965635	5965635	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:5965635C>T	ENST00000379999.5	+	17	2631	c.2527C>T	c.(2527-2529)Cag>Tag	p.Q843*	FBXO18_ENST00000379994.1_Intron|FBXO18_ENST00000397269.3_Nonsense_Mutation_p.Q279*|FBXO18_ENST00000362091.4_Nonsense_Mutation_p.Q792*	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	792					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						GATCCTTCTTCAGCCAGAGGA	0.438000													17	52					0	0	0.049695	0	0
TRPM3	80036	broad.mit.edu	37	9	73477941	73477941	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:73477941G>T	ENST00000377110.2	-	3	588	c.345C>A	c.(343-345)ctC>ctA	p.L115L	TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000377105.1_5'UTR|TRPM3_ENST00000437699.3_5'UTR|TRPM3_ENST00000423814.3_Silent_p.L117L|TRPM3_ENST00000377106.1_5'UTR|TRPM3_ENST00000377111.2_Silent_p.L115L|TRPM3_ENST00000377097.3_5'UTR|TRPM3_ENST00000357533.2_Silent_p.L117L|TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000396283.1_5'UTR	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	115						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CATTTCGGGAGAGGCGACTTT	0.507000													31	76					1.02151e-06	1.09503e-06	0.054565	1	0
SMARCD1	6602	broad.mit.edu	37	12	50483734	50483734	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:50483734T>A	ENST00000394963.4	+	7	1237	c.839T>A	c.(838-840)gTa>gAa	p.V280E	SMARCD1_ENST00000548573.1_Missense_Mutation_p.V78E|SMARCD1_ENST00000381513.4_Missense_Mutation_p.V280E	NM_003076.4	NP_003067.3	Q96GM5	SMRD1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	280	Interaction with SMARCC1 and SMARCC2.|Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			NS(1)|breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	18						GACGTGAATGTACGGTGTACT	0.557000													25	56					0	0	0.054565	0	0
TTN	7273	broad.mit.edu	37	2	179436378	179436378	+	Silent	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:179436378A>T	ENST00000589042.1	-	326	74705	c.74481T>A	c.(74479-74481)acT>acA	p.T24827T	TTN_ENST00000342992.6_Silent_p.T22259T|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Silent_p.T15762T|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Silent_p.T15887T|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.T23186T|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342175.6_Silent_p.T15954T|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23186	Fibronectin type-III 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCAGGAAAGAGTAATACTAT	0.433000													20	29					0	0	0.049695	0	0
RCL1	10171	broad.mit.edu	37	9	4833225	4833225	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:4833225G>A	ENST00000381750.4	+	4	679	c.456G>A	c.(454-456)ctG>ctA	p.L152L		NM_005772.3	NP_005763.3	Q9Y2P8	RCL1_HUMAN	RNA terminal phosphate cyclase-like 1	152					ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity			breast(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)		CATTTGAACTGAAGGTAAGAA	0.373000													17	84					0	0	0.069288	0	0
TRPC6	7225	broad.mit.edu	37	11	101347075	101347075	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:101347075C>A	ENST00000344327.3	-	6	2125	c.1701G>T	c.(1699-1701)ttG>ttT	p.L567F	TRPC6_ENST00000348423.4_Missense_Mutation_p.L451F|TRPC6_ENST00000360497.4_Missense_Mutation_p.L512F|TRPC6_ENST00000532133.1_Intron	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	567					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTACTTTCGTCAAGTCCTTCA	0.363000													16	48					8.28177e-16	9.8929e-16	0.043863	1	0
PDE6B	5158	broad.mit.edu	37	4	649750	649750	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:649750G>T	ENST00000255622.6	+	7	1057	c.1014G>T	c.(1012-1014)tgG>tgT	p.W338C	PDE6B_ENST00000429163.2_Missense_Mutation_p.W59C|PDE6B_ENST00000496514.1_Missense_Mutation_p.W338C	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	338	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CCGATCACTGGGCCCTGGCCA	0.652000													33	91					1.03484e-13	1.2013e-13	0.080422	1	0
MYPN	84665	broad.mit.edu	37	10	69926080	69926080	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:69926080C>A	ENST00000358913.5	+	10	2118	c.1630C>A	c.(1630-1632)Ctt>Att	p.L544I	MYPN_ENST00000540630.1_Missense_Mutation_p.L544I|MYPN_ENST00000354393.2_Missense_Mutation_p.L269I	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	544						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CAACGGGTCTCTTCACTCAGC	0.552000													39	37					8.94452e-30	1.16379e-29	0.048971	1	0
LGALS14	56891	broad.mit.edu	37	19	40199894	40199894	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:40199894G>A	ENST00000392052.3	+	4	584	c.361G>A	c.(361-363)Gtg>Atg	p.V121M	LGALS14_ENST00000360675.3_Missense_Mutation_p.V150M	NM_020129.2	NP_064514.1	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14	121	Galectin.					nucleus	sugar binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|stomach(2)	14	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			GCCAGCATCTGTGAAGATGCT	0.458000													15	60					0	0	0.038395	0	0
AKT1S1	84335	broad.mit.edu	37	19	50373285	50373285	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:50373285C>T	ENST00000391833.1	-	4	2649	c.660G>A	c.(658-660)gcG>gcA	p.A220A	AKT1S1_ENST00000391832.3_Silent_p.A220A|AKT1S1_ENST00000391834.2_Silent_p.A220A|AKT1S1_ENST00000391831.1_Silent_p.A220A|AKT1S1_ENST00000391835.1_Silent_p.A240A|AKT1S1_ENST00000344175.5_Silent_p.A220A	NM_001278160.1	NP_001265089.1	Q96B36	AKTS1_HUMAN	AKT1 substrate 1 (proline-rich)	220					negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|nerve growth factor receptor signaling pathway|neuroprotection|phosphatidylinositol-mediated signaling|regulation of survival gene product expression	cytosolic part	protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		CGCGCATGCTCGCCGCGATGC	0.716000													10	14					0	0	0.010729	0	0
OR51B2	79345	broad.mit.edu	37	11	5345279	5345279	+	Silent	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:5345279T>C	ENST00000328813.2	-	1	303	c.249A>G	c.(247-249)ctA>ctG	p.L83L	HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTCACCCATAGGATGCCCA	0.507000													18	68					0	0	0.043863	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282948	69282948	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:69282948C>A	ENST00000338352.2	+	1	608	c.574C>A	c.(574-576)Ccc>Acc	p.P192T		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	192	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CTTCAGCAACCCCGAGACCAG	0.612000													20	9					6.44725e-10	7.25575e-10	0.069288	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725741	140725741	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140725741T>A	ENST00000253812.6	+	1	2141	c.2141T>A	c.(2140-2142)cTc>cAc	p.L714H	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTGGCGCTCAGGCTGCGG	0.682000													28	89					0	0	0.048971	0	0
PLVAP	83483	broad.mit.edu	37	19	17488061	17488061	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:17488061G>A	ENST00000252590.4	-	1	98	c.37C>T	c.(37-39)Cgg>Tgg	p.R13W		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	13						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCCCCCGCCCGAGCGTAGGAC	0.652000													38	108					0	0	0.045515	0	0
FBLL1	345630	broad.mit.edu	37	5	167957247	167957247	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:167957247C>G	ENST00000338333.4	+	1	1127	c.738C>G	c.(736-738)ttC>ttG	p.F246L																								ACGTGATCTTCGCCGACGTGG	0.627000													13	40					0	0	0.043863	0	0
PSMB1	5689	broad.mit.edu	37	6	170846376	170846376	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:170846376G>A	ENST00000262193.6	-	5	584	c.486C>T	c.(484-486)tcC>tcT	p.S162S	PSMB1_ENST00000462957.1_5'UTR	NM_002793.3	NP_002784.1	P20618	PSB1_HUMAN	proteasome (prosome, macropain) subunit, beta type, 1	162					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	CAGCCTTGAAGGAGTCTCTCT	0.453000													22	39					0	0	0.024334	0	0
INTS8	55656	broad.mit.edu	37	8	95884155	95884155	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:95884155G>C	ENST00000523731.1	+	21	2591	c.2458G>C	c.(2458-2460)Gag>Cag	p.E820Q	INTS8_ENST00000447247.1_Missense_Mutation_p.E820Q	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	820					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					CACAGTGAAAGAGCTAGTTCG	0.348000													22	44					0	0	0.069288	0	0
CEP128	145508	broad.mit.edu	37	14	81209499	81209499	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:81209499T>A	ENST00000555265.1	-	19	3101	c.2726A>T	c.(2725-2727)aAg>aTg	p.K909M	CEP128_ENST00000281129.3_Missense_Mutation_p.K909M			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	909						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CTCAGATTCCTTGTTTTCAGT	0.433000													32	78					0	0	0.074837	0	0
PXDN	7837	broad.mit.edu	37	2	1684106	1684106	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:1684106C>T	ENST00000252804.4	-	7	639	c.589G>A	c.(589-591)Gac>Aac	p.D197N		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	197	LRRCT.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATTTCACAGTCGCAGTGAAGT	0.582000													18	48					0	0	0.062417	0	0
SLTM	79811	broad.mit.edu	37	15	59193471	59193471	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:59193471C>A	ENST00000380516.2	-	6	664	c.577G>T	c.(577-579)Gaa>Taa	p.E193*	SLTM_ENST00000536328.1_5'UTR|SLTM_ENST00000557950.1_5'UTR	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	193	Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTCTCATTTTCTTCTTCCTCA	0.254000													21	38					7.68411e-24	9.70917e-24	0.037714	1	0
LAMA4	3910	broad.mit.edu	37	6	112476083	112476083	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:112476083C>T	ENST00000230538.7	-	16	2423	c.2026G>A	c.(2026-2028)Gcc>Acc	p.A676T	LAMA4_ENST00000424408.2_Missense_Mutation_p.A669T|RP1-142L7.5_ENST00000425503.1_RNA|RP1-142L7.5_ENST00000588689.1_RNA|RP1-142L7.5_ENST00000585373.1_RNA|LAMA4_ENST00000522006.1_Missense_Mutation_p.A669T|LAMA4_ENST00000389463.4_Missense_Mutation_p.A669T	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	676	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AGTTCTCTGGCTTGATTGAGG	0.398000													22	78					0	0	0.024334	0	0
GATAD2B	57459	broad.mit.edu	37	1	153789011	153789011	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:153789011C>T	ENST00000368655.4	-	7	1197	c.954G>A	c.(952-954)atG>atA	p.M318I		NM_020699.2	NP_065750.1	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	318						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	38	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAGCAAGGTTCATATAGATGG	0.507000													37	41					0	0	0.036044	0	0
LRP1	4035	broad.mit.edu	37	12	57572344	57572344	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:57572344C>T	ENST00000243077.3	+	27	5030	c.4564C>T	c.(4564-4566)Ccc>Tcc	p.P1522S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1522					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CAACACCCAGCCCTTTGACCT	0.622000													55	128					0	0	0.048971	0	0
CDH9	1007	broad.mit.edu	37	5	26988331	26988331	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:26988331A>T	ENST00000231021.4	-	2	282	c.110T>A	c.(109-111)aTa>aAa	p.I37K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	37					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CAGACCCGCTATCTTTTTGCT	0.393000													19	65					0	0	0.043863	0	0
TPI1	7167	broad.mit.edu	37	12	6978853	6978853	+	Splice_Site	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:6978853T>C	ENST00000229270.4	+	5	907	c.568_splice	c.e5-1	p.D190_splice	TPI1_ENST00000488464.2_Splice_Site_p.D71_splice|TPI1_ENST00000396705.5_Splice_Site_p.D153_splice|TPI1_ENST00000535434.1_Splice_Site_p.D71_splice	NM_001159287.1	NP_001152759.1	P60174	TPIS_HUMAN	triosephosphate isomerase 1	153					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|skin(2)	19						GCCCTGCAGATAACGTGAAGG	0.577000											OREG0021638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	128					0	0	0.048971	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389862	77389862	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:77389862G>A	ENST00000282849.5	-	9	1853	c.1435C>T	c.(1435-1437)Cgc>Tgc	p.R479C		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	479	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AGATACTGGCGGCTGCAGGAA	0.488000													29	54					0	0	0.034045	0	0
CENPJ	55835	broad.mit.edu	37	13	25480420	25480420	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:25480420C>G	ENST00000381884.4	-	7	1941	c.1756G>C	c.(1756-1758)Gat>Cat	p.D586H	CENPJ_ENST00000545981.1_Missense_Mutation_p.D586H	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	586					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GATATTTCATCAGCAGCTTGT	0.358000													10	9					0	0	0.069234	0	0
IKBKB	3551	broad.mit.edu	37	8	42166509	42166509	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:42166509C>T	ENST00000520810.1	+	8	844	c.658C>T	c.(658-660)Cgg>Tgg	p.R220W	IKBKB_ENST00000520835.1_Missense_Mutation_p.R218W|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000519735.1_Missense_Mutation_p.R220W|IKBKB_ENST00000416505.2_Missense_Mutation_p.R161W|IKBKB_ENST00000379708.3_Intron	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	220	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	CACGGGCTTCCGGCCCTTCCT	0.627000													53	145					0	0	0.048971	0	0
PIGT	51604	broad.mit.edu	37	20	44049006	44049006	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:44049006C>T	ENST00000279036.6	+	7	884	c.804C>T	c.(802-804)ctC>ctT	p.L268L	PIGT_ENST00000543458.2_Silent_p.L212L|PIGT_ENST00000372689.5_Silent_p.L268L|PIGT_ENST00000279035.9_Silent_p.L166L|PIGT_ENST00000341555.5_Silent_p.L74L|PIGT_ENST00000545755.1_Silent_p.L6L|PIGT_ENST00000535404.1_Silent_p.L113L	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	268					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				CCCGAACCCTCACGGAGCCCT	0.592000													14	14					0	0	0.043863	0	0
FLNC	2318	broad.mit.edu	37	7	128497331	128497331	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:128497331C>A	ENST00000325888.8	+	46	7982	c.7721C>A	c.(7720-7722)gCc>gAc	p.A2574D	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.A2541D	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2574	Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACCTCATTGCCATCAAGTAC	0.617000													32	47					4.4194e-11	5.03841e-11	0.054565	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1910245	1910245	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:1910245C>T	ENST00000382722.5	-	31	3194	c.2832G>A	c.(2830-2832)tcG>tcA	p.S944S	CACNA2D4_ENST00000587995.1_Silent_p.S919S|CACNA2D4_ENST00000586184.1_Silent_p.S944S|CACNA2D4_ENST00000585708.1_Silent_p.S880S|CACNA2D4_ENST00000538450.1_Silent_p.S74S|CACNA2D4_ENST00000538027.2_Silent_p.S89S|CACNA2D4_ENST00000588077.1_Silent_p.S880S	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	944						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGTGGTGACTCGAGGGTTTGC	0.607000											OREG0021569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	84					0	0	0.045515	0	0
AMY2B	280	broad.mit.edu	37	1	104120463	104120463	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:104120463G>T	ENST00000361355.4	+	11	1958	c.1342G>T	c.(1342-1344)Gac>Tac	p.D448Y	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	448					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		CAACAATGATGACTGGTAAGT	0.338000													63	110					1.15062e-32	1.51682e-32	0.048971	1	0
PPIG	9360	broad.mit.edu	37	2	170462555	170462555	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:170462555A>G	ENST00000260970.3	+	5	363	c.143A>G	c.(142-144)aAg>aGg	p.K48R	PPIG_ENST00000462903.1_Missense_Mutation_p.K48R|PPIG_ENST00000409714.3_Missense_Mutation_p.K48R|PPIG_ENST00000448752.2_Missense_Mutation_p.K48R	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	48	PPIase cyclophilin-type.				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ATAGGTGAAAAGGGGACCGGG	0.353000													3	71					0	0	0.009096	0	0
KRT3	3850	broad.mit.edu	37	12	53189278	53189278	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:53189278G>T	ENST00000417996.2	-	1	623	c.549C>A	c.(547-549)ctC>ctA	p.L183L	KRT3_ENST00000309505.3_Silent_p.L183L	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	183	Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCTCCACATTGAGGGGCTGCA	0.562000													19	35					5.35267e-07	5.77329e-07	0.043863	1	0
DIDO1	11083	broad.mit.edu	37	20	61528345	61528345	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:61528345G>A	ENST00000266070.4	-	7	1917	c.1592C>T	c.(1591-1593)aCg>aTg	p.T531M	DIDO1_ENST00000395335.2_Missense_Mutation_p.T531M|DIDO1_ENST00000395340.1_Missense_Mutation_p.T531M|DIDO1_ENST00000395343.1_Missense_Mutation_p.T531M	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	531					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTCTTCCTTCGTGGCTACAAA	0.562000													10	18					0	0	0.013537	0	0
DICER1	23405	broad.mit.edu	37	14	95562743	95562743	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:95562743G>A	ENST00000526495.1	-	25	4805	c.4514C>T	c.(4513-4515)tCt>tTt	p.S1505F	DICER1_ENST00000393063.1_Missense_Mutation_p.S1505F|DICER1_ENST00000343455.3_Missense_Mutation_p.S1505F|DICER1_ENST00000527414.1_Missense_Mutation_p.S1505F|DICER1_ENST00000541352.1_Missense_Mutation_p.S1505F|DICER1_ENST00000556045.1_Missense_Mutation_p.S403F			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1505					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGCATCCCAAGAGCTGTAGTC	0.408000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				21	43					0	0	0.055883	0	0
USP32P3	347716	broad.mit.edu	37	17	20320027	20320027	+	RNA	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:20320027C>A	ENST00000583574.2	+	0	333																											CACCACACGTCAGCTCAAGTT	0.547000													13	48					1.67942e-08	1.86011e-08	0.038395	1	0
RHOQ	23433	broad.mit.edu	37	2	46808133	46808133	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:46808133G>T	ENST00000238738.4	+	5	848	c.529G>T	c.(529-531)Gag>Tag	p.E177*	PIGF_ENST00000281382.6_3'UTR	NM_012249.3	NP_036381.2	P17081	RHOQ_HUMAN	ras homolog family member Q	177					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TGTTTTTGATGAGGCTATCAT	0.348000													32	65					2.1956e-27	2.82522e-27	0.069456	1	0
NFE2L3	9603	broad.mit.edu	37	7	26224622	26224622	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:26224622C>G	ENST00000056233.3	+	4	1563	c.1304C>G	c.(1303-1305)tCt>tGt	p.S435C		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	435					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GTCATCAAGTCTAATTCCTCT	0.403000													37	221					0	0	0.080422	0	0
DST	667	broad.mit.edu	37	6	56346868	56346868	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:56346868T>C	ENST00000370754.5	-	90	21417	c.21418A>G	c.(21418-21420)Act>Gct	p.T7140A	DST_ENST00000244364.6_Missense_Mutation_p.T4548A|DST_ENST00000370788.2_Missense_Mutation_p.T4765A|DST_ENST00000312431.6_3'UTR|DST_ENST00000421834.2_Missense_Mutation_p.T4874A|DST_ENST00000370769.4_Missense_Mutation_p.T6962A|DST_ENST00000446842.2_Missense_Mutation_p.T6636A|DST_ENST00000361203.3_Missense_Mutation_p.T6851A			Q03001	DYST_HUMAN	dystonin	6960					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCAATGAGAGTCCGGAGAGCA	0.443000													8	15					0	0	0.047766	0	0
CD47	961	broad.mit.edu	37	3	107798905	107798905	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:107798905G>C	ENST00000355354.7	-	2	449	c.333C>G	c.(331-333)aaC>aaG	p.N111K	CD47_ENST00000361309.5_Missense_Mutation_p.N111K	NM_198793.2	NP_942088.1	Q08722	CD47_HUMAN	CD47 molecule	111	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			CACAAGTGTAGTTTCCTGTGT	0.363000													52	190					0	0	0.048971	0	0
UBAP1	51271	broad.mit.edu	37	9	34242063	34242063	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:34242063C>G	ENST00000536252.1	+	5	1438	c.1040C>G	c.(1039-1041)tCt>tGt	p.S347C	UBAP1_ENST00000545103.1_Missense_Mutation_p.S411C|UBAP1_ENST00000379186.4_Missense_Mutation_p.S347C|UBAP1_ENST00000540348.1_Missense_Mutation_p.S347C|UBAP1_ENST00000543944.1_Missense_Mutation_p.S383C|UBAP1_ENST00000359544.2_Missense_Mutation_p.S347C|UBAP1_ENST00000297661.4_Missense_Mutation_p.S347C	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	347						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			TCTGTTTTGTCTGTGTGCACA	0.498000													46	137					0	0	0.048971	0	0
SSTR5	6755	broad.mit.edu	37	16	1129519	1129519	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:1129519C>T	ENST00000293897.4	+	1	739	c.651C>T	c.(649-651)atC>atT	p.I217I	SSTR5_ENST00000562758.1_Intron|SSTR5_ENST00000397547.2_Silent_p.I217I	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	217					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TGCTGGTCATCTGCCTGTGCT	0.697000													14	45					0	0	0.020292	0	0
EBF3	253738	broad.mit.edu	37	10	131761712	131761712	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:131761712G>T	ENST00000368648.3	-	2	282	c.210C>A	c.(208-210)ttC>ttA	p.F70L	EBF3_ENST00000355311.5_Missense_Mutation_p.F70L	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	70					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GCGCCAGCACGAAGTGGAAGA	0.582000													15	65					6.31663e-08	6.93047e-08	0.024245	1	0
SIRPB2	284759	broad.mit.edu	37	20	1456860	1456860	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:1456860G>A	ENST00000359801.3	-	5	1017	c.981C>T	c.(979-981)ggC>ggT	p.G327G	SIRPB2_ENST00000444444.1_Silent_p.G229G	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	327						integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CTCCTGCTGGGCCTGTGGTCT	0.607000													37	100					0	0	0.045515	0	0
ANO1	55107	broad.mit.edu	37	11	69950235	69950235	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:69950235T>A	ENST00000355303.5	+	4	976	c.671T>A	c.(670-672)tTc>tAc	p.F224Y	ANO1_ENST00000538023.1_Missense_Mutation_p.F224Y|ANO1_ENST00000530676.1_Missense_Mutation_p.F108Y|ANO1_ENST00000316296.5_Missense_Mutation_p.F196Y|ANO1_ENST00000398543.2_Missense_Mutation_p.F108Y	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	224					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCCTATCCCTTCTCCCGGGAG	0.522000													7	13					0	0	0.047766	0	0
TRIM54	57159	broad.mit.edu	37	2	27505683	27505683	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:27505683C>T	ENST00000296098.4	+	1	354	c.84C>T	c.(82-84)atC>atT	p.I28I	TRIM54_ENST00000380075.2_Silent_p.I28I	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	28					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGCCCCATCTGCCTGGAGA	0.587000													126	249					0	0	0.048971	0	0
DNAH3	55567	broad.mit.edu	37	16	21139082	21139082	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:21139082C>A	ENST00000261383.3	-	8	1133	c.1134G>T	c.(1132-1134)ttG>ttT	p.L378F	CTC-508F8.1_ENST00000575612.1_RNA|DNAH3_ENST00000415178.1_Missense_Mutation_p.L378F	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	378	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCTGCAGAGGCAATTTTCCCG	0.473000													92	107					3.01496e-42	4.02762e-42	0.048971	1	0
PHF14	9678	broad.mit.edu	37	7	11068308	11068308	+	Splice_Site	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:11068308G>C	ENST00000403050.3	+	7	1770	c.1317_splice	c.e7-1	p.E440_splice	PHF14_ENST00000445996.2_Splice_Site_p.E155_splice	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	440							zinc ion binding	p.E440*(1)		NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TTTGTTGTAGGAGTGTAGCTT	0.393000													15	8					0	0	0.038395	0	0
MBD5	55777	broad.mit.edu	37	2	149226874	149226874	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:149226874G>T	ENST00000407073.1	+	9	2359	c.1362G>T	c.(1360-1362)gaG>gaT	p.E454D	MBD5_ENST00000404807.1_Missense_Mutation_p.E454D	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	454						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GAAGGATTGAGGCATCGCCCC	0.502000													12	18					1.3612e-06	1.45695e-06	0.024245	1	0
COL4A2	1284	broad.mit.edu	37	13	111160490	111160490	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:111160490G>T	ENST00000360467.5	+	47	5109	c.4803G>T	c.(4801-4803)gcG>gcT	p.A1601A	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1601	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCGCCATCGCGGTCCACAGTC	0.602000													31	64					5.77227e-19	7.16417e-19	0.037714	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19698834	19698834	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:19698834C>A	ENST00000284885.3	-	16	1869	c.1836G>T	c.(1834-1836)atG>atT	p.M612I		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	612	CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						GAAGCACAGTCATTCTGTTGG	0.458000													41	77					5.44703e-19	6.78455e-19	0.036044	1	0
MLXIP	22877	broad.mit.edu	37	12	122623364	122623364	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:122623364C>T	ENST00000319080.6	+	15	2519	c.2387C>T	c.(2386-2388)tCc>tTc	p.S796F	MLXIP_ENST00000538698.1_Missense_Mutation_p.S403F			Q9HAP2	MLXIP_HUMAN	MLX interacting protein	796					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		CATTTCAGCTCCTGCCAGCAG	0.602000													10	9					0	0	0.010729	0	0
EBF1	1879	broad.mit.edu	37	5	158267057	158267057	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:158267057G>A	ENST00000313708.6	-	7	898	c.616C>T	c.(616-618)Cgt>Tgt	p.R206C	EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Missense_Mutation_p.R206C|EBF1_ENST00000380654.4_Missense_Mutation_p.R183C	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	206					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGCATGTCACGTGGGTTTCCC	0.383000			T	HMGA2	lipoma								21	64					0	0	0.018920	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638527	56638527	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:56638527C>T	ENST00000267116.7	-	24	2752	c.2631G>A	c.(2629-2631)ctG>ctA	p.L877L		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	877							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						GATGCTGCAGCAGCATCCGGA	0.597000													20	56					0	0	0.069288	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95494780	95494780	+	RNA	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:95494780T>C	ENST00000432432.2	-	0	1164					NR_040113.1																						ATTCTTTCTTTGTACTGCTCC	0.338000													36	67					0	0	0.039052	0	0
ALMS1	7840	broad.mit.edu	37	2	73676340	73676340	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:73676340C>G	ENST00000264448.6	+	8	2794	c.2683C>G	c.(2683-2685)Cag>Gag	p.Q895E	ALMS1_ENST00000377715.1_Missense_Mutation_p.Q895E|ALMS1_ENST00000409009.1_Missense_Mutation_p.Q853E	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	895	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACCAGGTGATCAGAAGACTGG	0.458000													37	71					0	0	0.033182	0	0
ZNF407	55628	broad.mit.edu	37	18	72343820	72343820	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:72343820A>G	ENST00000299687.5	+	1	845	c.845A>G	c.(844-846)cAg>cGg	p.Q282R	ZNF407_ENST00000309902.6_Missense_Mutation_p.Q282R|ZNF407_ENST00000577538.1_Missense_Mutation_p.Q282R|ZNF407_ENST00000582337.1_Missense_Mutation_p.Q282R	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGATTTGTACAGATCTTAACA	0.363000													38	36					0	0	0.045515	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514362	113514362	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:113514362C>G	ENST00000541405.1	-	4	614	c.91G>C	c.(91-93)Gag>Cag	p.E31Q	CKAP2L_ENST00000481732.1_5'UTR|CKAP2L_ENST00000302450.6_Missense_Mutation_p.E196Q			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	196						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						GGCTTCCTCTCAGGTTCTGTT	0.338000													7	23					0	0	0.029380	0	0
FLG2	388698	broad.mit.edu	37	1	152324674	152324674	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:152324674C>G	ENST00000388718.5	-	3	5660	c.5588G>C	c.(5587-5589)gGa>gCa	p.G1863A	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1863							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGACTGTCCATGACCAGA	0.493000													165	198					0	0	0.048971	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741192	140741192	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140741192A>T	ENST00000522605.1	+	1	1490	c.1490A>T	c.(1489-1491)aAg>aTg	p.K497M	PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGACCTGAAGCCGCGGGAG	0.612000													27	29					0	0	0.045705	0	0
KRT75	9119	broad.mit.edu	37	12	52827669	52827669	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:52827669G>T	ENST00000252245.5	-	1	640	c.420C>A	c.(418-420)ccC>ccA	p.P140P		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	140	Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		GCTGGATGGTGGGGTCGATTT	0.597000													42	113					6.27289e-28	8.0866e-28	0.048971	1	0
BCLAF1	9774	broad.mit.edu	37	6	136597195	136597195	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:136597195C>A	ENST00000531224.1	-	5	1720	c.1468G>T	c.(1468-1470)Gta>Tta	p.V490L	BCLAF1_ENST00000392348.2_Missense_Mutation_p.V488L|BCLAF1_ENST00000527759.1_Missense_Mutation_p.V488L|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000527536.1_Missense_Mutation_p.V490L|BCLAF1_ENST00000353331.4_Missense_Mutation_p.V488L	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	490					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTTTCTTTACTGTTATTCTT	0.368000													22	130					7.41877e-09	8.25619e-09	0.062417	1	0
NLRP7	199713	broad.mit.edu	37	19	55446005	55446005	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:55446005G>T	ENST00000446217.1	-	9	2809	c.2407C>A	c.(2407-2409)Ccg>Acg	p.P803T	NLRP7_ENST00000590030.1_Missense_Mutation_p.P775T|NLRP7_ENST00000340844.2_Missense_Mutation_p.P775T|NLRP7_ENST00000328092.5_Missense_Mutation_p.P747T|NLRP7_ENST00000448121.2_Missense_Mutation_p.P747T|NLRP7_ENST00000592784.1_Missense_Mutation_p.P775T|NLRP7_ENST00000588756.1_Missense_Mutation_p.P775T			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	775							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CACTGCTCCGGGGTGGCACAG	0.502000													13	22					0.00185496	0.00191233	0.016723	1	0
IPO4	79711	broad.mit.edu	37	14	24656911	24656911	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:24656911G>A	ENST00000354464.6	-	5	546	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	124					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		GTACTGTGCTGAAGCAGCTGC	0.582000													31	77					0	0	0.025465	0	0
KISS1R	84634	broad.mit.edu	37	19	917741	917741	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:917741A>G	ENST00000234371.5	+	1	392	c.239A>G	c.(238-240)tAc>tGc	p.Y80C	KISS1R_ENST00000606939.1_Missense_Mutation_p.Y80C	NM_032551.4	NP_115940.2	Q969F8	KISSR_HUMAN	KISS1 receptor	80					behavior	integral to membrane|plasma membrane	neuropeptide receptor activity|protein binding			cervix(1)|kidney(1)|ovary(1)|pancreas(1)|skin(1)	5		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCAACTTCTACATCGGTGAG	0.701000													5	16					0	0	0.029380	0	0
GYPC	2995	broad.mit.edu	37	2	127451438	127451438	+	Splice_Site	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:127451438A>G	ENST00000259254.4	+	3	437		c.e3-1		GYPC_ENST00000409836.3_Splice_Site|GYPC_ENST00000464053.1_Splice_Site|GYPC_ENST00000356887.7_Splice_Site	NM_002101.4	NP_002092.1	P04921	GLPC_HUMAN	glycophorin C (Gerbich blood group)							cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|prostate(2)|urinary_tract(1)	13	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CTCTGTTCACAGAGCCTGATC	0.542000													28	74					0	0	0.041601	0	0
RAB21	23011	broad.mit.edu	37	12	72167776	72167776	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:72167776G>T	ENST00000261263.3	+	4	621	c.365G>T	c.(364-366)gGa>gTa	p.G122V		NM_014999.2	NP_055814.1	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	122					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding			large_intestine(1)|lung(4)|prostate(1)	6						AAAATGTTGGGAAATGAAATC	0.289000													18	56					2.39556e-15	2.8422e-15	0.076483	1	0
LRRC66	339977	broad.mit.edu	37	4	52860629	52860629	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:52860629C>A	ENST00000343457.3	-	4	2565	c.2559G>T	c.(2557-2559)caG>caT	p.Q853H		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	853						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTGGTGTTTGCTGTAAAACGT	0.398000													35	77					1.04594e-18	1.29585e-18	0.025465	1	0
MROH2B	133558	broad.mit.edu	37	5	41012727	41012727	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:41012727C>T	ENST00000399564.4	-	30	3543	c.3093G>A	c.(3091-3093)atG>atA	p.M1031I	MROH2B_ENST00000506092.2_Missense_Mutation_p.M586I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GGACAGTGATCATCCATATGC	0.458000													18	65					0	0	0.038395	0	0
CD47	961	broad.mit.edu	37	3	107798924	107798924	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:107798924G>C	ENST00000355354.7	-	2	430	c.314C>G	c.(313-315)gCt>gGt	p.A105G	CD47_ENST00000361309.5_Missense_Mutation_p.A105G	NM_198793.2	NP_942088.1	Q08722	CD47_HUMAN	CD47 molecule	105	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GTGTGAGACAGCATCACTCTT	0.393000													53	185					0	0	0.048971	0	0
SYF2	25949	broad.mit.edu	37	1	25549784	25549784	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:25549784C>G	ENST00000236273.4	-	7	730	c.705G>C	c.(703-705)caG>caC	p.Q235H	SYF2_ENST00000354361.3_Missense_Mutation_p.Q193H	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	235						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		TTTCCAAATTCTGTTTAATTT	0.338000													28	77					0	0	0.037714	0	0
USO1	8615	broad.mit.edu	37	4	76726444	76726444	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:76726444G>C	ENST00000538159.1	+	20	2304	c.2304G>C	c.(2302-2304)atG>atC	p.M768I	USO1_ENST00000514213.2_Missense_Mutation_p.M744I			O60763	USO1_HUMAN	USO1 vesicle transport factor	759					intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGGACTCTATGATTGAAAATA	0.333000													5	7					0	0	0.021553	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64709193	64709193	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:64709193G>A	ENST00000338957.4	+	1	579	c.512G>A	c.(511-513)aGa>aAa	p.R171K	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.R160K	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	160							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCCAGCTCCAGAGAGATTGCA	0.438000													33	9					0	0	0.069456	0	0
ATRNL1	26033	broad.mit.edu	37	10	117607396	117607396	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:117607396C>T	ENST00000355044.3	+	28	4038	c.3912C>T	c.(3910-3912)ccC>ccT	p.P1304P	ATRNL1_ENST00000423111.2_Silent_p.P355P|ATRNL1_ENST00000303745.7_Silent_p.P97P	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1304						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGGGGGCACCCAAGCCAATTG	0.458000													12	18					0	0	0.013537	0	0
COPG1	22820	broad.mit.edu	37	3	128973901	128973901	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:128973901C>T	ENST00000314797.6	+	7	577	c.473C>T	c.(472-474)tCt>tTt	p.S158F		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	158					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GTCTCCAGCTCTGCCCTCGTG	0.517000													19	62					0	0	0.069288	0	0
SPTB	6710	broad.mit.edu	37	14	65240051	65240051	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:65240051T>A	ENST00000389722.3	-	24	5118	c.5065A>T	c.(5065-5067)Atg>Ttg	p.M1689L	SPTB_ENST00000389720.3_Missense_Mutation_p.M1689L|SPTB_ENST00000389721.5_Missense_Mutation_p.M1689L|SPTB_ENST00000542895.1_Missense_Mutation_p.M1689L|SPTB_ENST00000556626.1_Missense_Mutation_p.M1689L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1689					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGGTGGTACATGTTCTCCAGC	0.562000													39	82					0	0	0.033182	0	0
FRAS1	80144	broad.mit.edu	37	4	79350311	79350311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:79350311C>T	ENST00000264895.6	+	36	5214	c.4774C>T	c.(4774-4776)Cag>Tag	p.Q1592*	FRAS1_ENST00000325942.6_Nonsense_Mutation_p.Q1592*	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1591					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCCCAGTGATCAGCAACTGCC	0.512000													3	12					0	0	0.004672	0	0
CDC27	996	broad.mit.edu	37	17	45234726	45234726	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:45234726G>C	ENST00000066544.3	-	6	593	c.500C>G	c.(499-501)aCa>aGa	p.T167R	CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000531206.1_Missense_Mutation_p.T167R|CDC27_ENST00000446365.2_Missense_Mutation_p.T106R|CDC27_ENST00000527547.1_Missense_Mutation_p.T167R	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	167					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						GAATTTAAATGTTTGGTCAGG	0.368000													3	80					0	0	0.029380	0	0
DMRT3	58524	broad.mit.edu	37	9	977286	977286	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:977286A>G	ENST00000190165.2	+	1	323	c.285A>G	c.(283-285)ccA>ccG	p.P95P		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	95					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GCGCTCTGCCAGGgcccccgc	0.781000													7	21					0	0	0.038147	0	0
IRF4	3662	broad.mit.edu	37	6	401593	401593	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:401593G>C	ENST00000380956.4	+	7	1041	c.915G>C	c.(913-915)gaG>gaC	p.E305D		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	305					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		AAAACATTGAGAAGCTGCTGA	0.602000			T	IGH@	MM								17	26					0	0	0.043863	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24517419	24517419	+	RNA	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:24517419G>C	ENST00000558293.1	+	0	492					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		AGTGGTGCCAGAAATGGAGAA	0.527000													8	28					0	0	0.069234	0	0
POLQ	10721	broad.mit.edu	37	3	121264695	121264695	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:121264695C>T	ENST00000264233.5	-	1	158	c.30G>A	c.(28-30)cgG>cgA	p.R10R		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	10					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		CTGAACGCCGCCGTTTCCCAC	0.647000								DNA polymerases (catalytic subunits)					9	35					0	0	0.069234	0	0
TDRD1	56165	broad.mit.edu	37	10	115986915	115986915	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:115986915C>T	ENST00000251864.2	+	23	3413	c.3260C>T	c.(3259-3261)tCt>tTt	p.S1087F	TDRD1_ENST00000369282.1_Intron|TDRD1_ENST00000369280.1_Intron|TDRD1_ENST00000369281.2_Missense_Mutation_p.S973F|TDRD1_ENST00000422662.1_Intron	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1087					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GTAATGCTTTCTGTGAAAGGA	0.328000													13	24					0	0	0.016723	0	0
TTN	7273	broad.mit.edu	37	2	179397734	179397734	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:179397734G>A	ENST00000589042.1	-	358	103832	c.103608C>T	c.(103606-103608)ctC>ctT	p.L34536L	TTN-AS1_ENST00000592182.1_RNA|TTN_ENST00000342992.6_Silent_p.L31968L|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN_ENST00000460472.2_Silent_p.L25471L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Silent_p.L25596L|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN_ENST00000591111.1_Silent_p.L32895L|TTN_ENST00000342175.6_Silent_p.L25663L|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000431259.2_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32895							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGGCATCCGGAGTTTTCTCT	0.453000													5	159					0	0	0.029380	0	0
IGSF5	150084	broad.mit.edu	37	21	41151172	41151172	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:41151172C>T	ENST00000380588.4	+	5	977	c.874C>T	c.(874-876)Cgt>Tgt	p.R292C	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	292	Cys-rich.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				ctgctgccgccgtcgttgttg	0.458000													17	27					0	0	0.028581	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337432	22337432	+	RNA	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:22337432G>T	ENST00000390436.2	+	0	246																											AAATGTGGGCGAAAAGAAAGA	0.428000													54	106					7.41606e-26	9.45581e-26	0.048971	1	0
RBM34	23029	broad.mit.edu	37	1	235324524	235324524	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:235324524C>T	ENST00000408888.3	-	1	248	c.18G>A	c.(16-18)atG>atA	p.M6I	RBM34_ENST00000366606.3_Start_Codon_SNP_p.M1I			P42696	RBM34_HUMAN	RNA binding motif protein 34	6						nucleolus	nucleotide binding|RNA binding	p.M6I(1)		central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TCCGTTTGCTCATCCCTTCCA	0.622000													77	120					0	0	0.048971	0	0
SPATA16	83893	broad.mit.edu	37	3	172634193	172634193	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:172634193C>T	ENST00000351008.3	-	9	1600	c.1417G>A	c.(1417-1419)Gag>Aag	p.E473K		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	473					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TGGGACTGCTCCTTTACTCTC	0.463000													122	177					0	0	0.048971	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683113	50683113	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:50683113G>T	ENST00000008391.3	+	2	552	c.324G>T	c.(322-324)ggG>ggT	p.G108G		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	108							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TCCACCACGGGGAGCCCACCG	0.622000													26	59					1.50538e-07	1.63628e-07	0.030593	1	0
KLHL4	56062	broad.mit.edu	37	X	86773043	86773043	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:86773043G>T	ENST00000373119.4	+	1	292	c.147G>T	c.(145-147)caG>caT	p.Q49H	KLHL4_ENST00000373114.4_Missense_Mutation_p.Q49H	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	49						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						CCCCGGTTCAGGGCAGGTTGA	0.547000													14	12					0.0383953	0.0388392	0.038395	1	0
PPP1R1A	5502	broad.mit.edu	37	12	54975868	54975868	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:54975868C>T	ENST00000257905.8	-	5	465	c.295G>A	c.(295-297)Gag>Aag	p.E99K	PPP1R1A_ENST00000547431.1_Intron	NM_006741.3	NP_006732.3	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	99					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						TCAGGTTCCTCTCCTTGCTGC	0.597000													10	32					0	0	0.010729	0	0
PLXNC1	10154	broad.mit.edu	37	12	94642146	94642146	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:94642146C>G	ENST00000258526.4	+	14	2985	c.2736C>G	c.(2734-2736)atC>atG	p.I912M		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	912					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTAAAGGCATCAAGACTGCAA	0.393000													33	45					0	0	0.030466	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													8	138					0	0	0.047766	0	0
RHOJ	57381	broad.mit.edu	37	14	63735881	63735881	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:63735881G>T	ENST00000316754.3	+	2	694	c.232G>T	c.(232-234)Gga>Tga	p.G78*	RHOJ_ENST00000557133.1_3'UTR|RHOJ_ENST00000555125.1_Nonsense_Mutation_p.G78*	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	78					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		TGACACCGCGGGACAGGTACA	0.448000													18	62					0.000375601	0.00039009	0.076483	1	0
MRGBP	55257	broad.mit.edu	37	20	61428022	61428022	+	Splice_Site	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:61428022C>T	ENST00000370487.3	+	1	218	c.148_splice	c.e1+1	p.V49_splice		NM_018270.4	NP_060740.1			MRG/MORF4L binding protein																		ACAAGCCCGTCGGTGAGCGCC	0.791000													6	7					0	0	0.029380	0	0
GLIS1	148979	broad.mit.edu	37	1	54060371	54060371	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:54060371C>A	ENST00000312233.2	-	3	771	c.205G>T	c.(205-207)Ggc>Tgc	p.G69C		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	69					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGGGGTAGGCCCAAGACGCAG	0.667000													7	16					0.00198382	0.00203917	0.029380	1	0
PRDM7	11105	broad.mit.edu	37	16	90126912	90126912	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:90126912G>T	ENST00000449207.2	-	9	1089	c.1070C>A	c.(1069-1071)tCt>tAt	p.S357Y	PRDM7_ENST00000407825.1_Intron|PRDM7_ENST00000325921.6_Intron	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	357	SET.			S -> Y (in Ref. 2; AAF78084).		chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCATCCCCAGACCAGACCAG	0.532000													4	93					0.00909568	0.00928131	0.009096	1	0
RFX5	5993	broad.mit.edu	37	1	151318730	151318730	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:151318730C>G	ENST00000290524.4	-	3	245	c.67G>C	c.(67-69)Gag>Cag	p.E23Q	RFX5_ENST00000478564.1_5'UTR|RFX5_ENST00000368870.2_Missense_Mutation_p.E23Q|RFX5_ENST00000452513.2_Missense_Mutation_p.E23Q|RFX5_ENST00000452671.2_Missense_Mutation_p.E23Q	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	23						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCCCCAGCCTCAGCACCACCT	0.567000													90	100					0	0	0.048971	0	0
CSF3R	1441	broad.mit.edu	37	1	36939405	36939405	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:36939405C>G	ENST00000373103.1	-	5	992	c.445G>C	c.(445-447)Gag>Cag	p.E149Q	CSF3R_ENST00000331941.5_Missense_Mutation_p.E149Q|CSF3R_ENST00000338937.5_Missense_Mutation_p.E149Q|CSF3R_ENST00000440588.2_Missense_Mutation_p.E149Q|CSF3R_ENST00000418048.2_Missense_Mutation_p.E149Q|CSF3R_ENST00000373104.1_Missense_Mutation_p.E149Q|CSF3R_ENST00000373106.1_Missense_Mutation_p.E149Q|CSF3R_ENST00000361632.4_Missense_Mutation_p.E149Q	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	149	Fibronectin type-III 1.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AGGTGGGTCTCAGGTCCTGGC	0.597000													20	54					0	0	0.049695	0	0
NLRP14	338323	broad.mit.edu	37	11	7064056	7064056	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:7064056G>T	ENST00000299481.4	+	4	1145	c.799G>T	c.(799-801)Gcc>Tcc	p.A267S		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	267	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ACTGAACTTTGCCTTTGAAGA	0.468000													30	65					4.02929e-09	4.50559e-09	0.045705	1	0
WDFY3	23001	broad.mit.edu	37	4	85686979	85686979	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:85686979C>A	ENST00000322366.6	-	32	5579	c.5172G>T	c.(5170-5172)aaG>aaT	p.K1724N	WDFY3_ENST00000295888.4_Missense_Mutation_p.K1724N			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1724						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAGTTCCAATCTTATTAGTTA	0.353000													20	61					3.5997e-14	4.21369e-14	0.069288	1	0
SCN1A	6323	broad.mit.edu	37	2	166903286	166903286	+	Silent	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:166903286T>C	ENST00000423058.2	-	9	1388	c.1371A>G	c.(1369-1371)gcA>gcG	p.A457A	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Silent_p.A457A|SCN1A_ENST00000375405.3_Silent_p.A457A|SCN1A_ENST00000409050.1_Silent_p.A457A|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	457						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTACCTGAGCTGCCTCCTGTT	0.458000													14	40					0	0	0.024245	0	0
C16orf90	646174	broad.mit.edu	37	16	3544590	3544590	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:3544590G>T	ENST00000437192.3	-	2	336	c.334C>A	c.(334-336)Cca>Aca	p.P112T	LA16c-306E5.3_ENST00000574423.2_RNA	NM_001080524.1	NP_001073993.1	A8MZG2	CP090_HUMAN	chromosome 16 open reading frame 90	102										large_intestine(1)	1						CTGTTACGTGGGCCCAGAGTC	0.672000													48	49					8.52622e-23	1.07345e-22	0.048971	1	0
ECM2	1842	broad.mit.edu	37	9	95258649	95258649	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:95258649G>A	ENST00000344604.5	-	10	2197	c.2048C>T	c.(2047-2049)tCa>tTa	p.S683L	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	683					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TCTTATGCATGAAAATGTGTA	0.299000													7	184					0	0	0.038147	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518041	113518041	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:113518041G>T	ENST00000284601.3	-	4	3174	c.3106C>A	c.(3106-3108)Caa>Aaa	p.Q1036K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	1036					glycogen metabolic process	integral to membrane		p.Q1036*(1)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TATAGTGATTGCCCAGAGCTT	0.398000													63	180					7.45626e-27	9.55931e-27	0.048971	1	0
LAIR2	3904	broad.mit.edu	37	19	55021737	55021737	+	Splice_Site	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:55021737G>A	ENST00000301202.2	+	5	539	c.415_splice	c.e5-1	p.G139_splice	LAIR2_ENST00000351841.2_Splice_Site_p.G122_splice	NM_002288.4	NP_002279.2	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like receptor 2	139						extracellular region	receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)	18	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		TCCTCACAGGGACTGTGCCAG	0.468000													21	65					0	0	0.076483	0	0
MROH9	80133	broad.mit.edu	37	1	170967360	170967360	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:170967360T>A	ENST00000367759.4	+	15	1695	c.1541T>A	c.(1540-1542)gTa>gAa	p.V514E	MROH9_ENST00000367758.3_Missense_Mutation_p.V514E	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		AAGCTCTCAGTAGAAGGTCCT	0.398000													23	85					0	0	0.062417	0	0
ALMS1	7840	broad.mit.edu	37	2	73826634	73826634	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:73826634A>G	ENST00000264448.6	+	17	11762	c.11651A>G	c.(11650-11652)aAg>aGg	p.K3884R	ALMS1_ENST00000409009.1_Missense_Mutation_p.K3842R	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3884					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ATGTTAAACAAGGGCATACAA	0.338000													43	96					0	0	0.048971	0	0
SP4	6671	broad.mit.edu	37	7	21469387	21469387	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:21469387G>A	ENST00000222584.3	+	3	822	c.604G>A	c.(604-606)Ggt>Agt	p.G202S		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	202					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						CATTTCTGCAGGTAATAATCA	0.418000													54	281					0	0	0.048971	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170115	70170115	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:70170115G>T	ENST00000342745.4	+	3	438	c.125G>T	c.(124-126)tGc>tTc	p.C42F		NM_014734.3	NP_055549.1	Q92537	K0247_HUMAN	KIAA0247	42	Sushi.					integral to membrane				endometrium(1)|kidney(1)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)	10				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		TTTGCAGTGTGCCCCCTACCA	0.587000													37	110					2.9001e-28	3.74552e-28	0.048971	1	0
SLC4A4	8671	broad.mit.edu	37	4	72215656	72215656	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:72215656A>G	ENST00000340595.3	+	2	481	c.285A>G	c.(283-285)gaA>gaG	p.E95E	SLC4A4_ENST00000512686.1_Silent_p.E95E|SLC4A4_ENST00000351898.6_Silent_p.E139E|SLC4A4_ENST00000264485.5_Silent_p.E139E|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000425175.1_Silent_p.E139E	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	139						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AAAAAGTGGAACAGGGTGGGG	0.433000													24	51					0	0	0.034045	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939586	150939586	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:150939586T>G	ENST00000392811.2	-	6	995	c.521A>C	c.(520-522)gAg>gCg	p.E174A	SMARCD3_ENST00000262188.8_Missense_Mutation_p.E187A|SMARCD3_ENST00000356800.2_Missense_Mutation_p.E174A|SMARCD3_ENST00000477169.1_5'UTR	NM_003078.3	NP_003069.2	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	187					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(2)	15			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGCTTCCCCTCCACCCGTAG	0.577000													67	54					0	0	0.048971	0	0
ATRX	546	broad.mit.edu	37	X	76972666	76972666	+	Silent	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:76972666T>A	ENST00000373344.5	-	2	289	c.75A>T	c.(73-75)tcA>tcT	p.S25S	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000373341.1_5'UTR|ATRX_ENST00000395603.3_Silent_p.S25S	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	25					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ATTCTTCTGATGAGTGTGCAA	0.343000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						49	24					0	0	0.048971	0	0
PIK3C3	5289	broad.mit.edu	37	18	39637886	39637886	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:39637886G>T	ENST00000262039.4	+	22	2389	c.2303G>T	c.(2302-2304)cGg>cTg	p.R768L	PIK3C3_ENST00000593098.1_Missense_Mutation_p.R253L|PIK3C3_ENST00000588156.1_5'UTR|PIK3C3_ENST00000398870.3_Missense_Mutation_p.R705L	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	768	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						ATTTTGGGTCGGGATCCAAAG	0.428000										TSP Lung(28;0.18)			17	30					6.33239e-15	7.44987e-15	0.055883	1	0
ZNF326	284695	broad.mit.edu	37	1	90478797	90478797	+	Splice_Site	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:90478797G>T	ENST00000340281.4	+	7	1069		c.e7+1		ZNF326_ENST00000370447.2_Splice_Site|ZNF326_ENST00000455342.2_Splice_Site	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		ATGGATACAGGTTTGTACTTA	0.348000													10	10					0.000442599	0.000458992	0.058154	1	0
MDGA2	161357	broad.mit.edu	37	14	47351289	47351289	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:47351289A>T	ENST00000426342.1	-	11	2226	c.1480T>A	c.(1480-1482)Ttt>Att	p.F494I	MDGA2_ENST00000399222.3_5'UTR|MDGA2_ENST00000399232.2_Missense_Mutation_p.F792I|MDGA2_ENST00000357362.3_Missense_Mutation_p.F494I|MDGA2_ENST00000439988.2_Missense_Mutation_p.F723I	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	723	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CCTTCACCAAATTTGGTGAGA	0.289000													6	13					0	0	0.047766	0	0
USH2A	7399	broad.mit.edu	37	1	215848206	215848206	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:215848206G>T	ENST00000366943.2	-	63	13433	c.13047C>A	c.(13045-13047)atC>atA	p.I4349I	USH2A_ENST00000307340.3_Silent_p.I4349I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4349	Fibronectin type-III 28.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCAGAGTTGTGATGCTGGTGG	0.512000										HNSCC(13;0.011)			33	32					3.33393e-15	3.94215e-15	0.074837	1	0
PBDC1	51260	broad.mit.edu	37	X	75396725	75396725	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:75396725C>G	ENST00000373358.3	+	5	510	c.307C>G	c.(307-309)Cca>Gca	p.P103A	PBDC1_ENST00000373357.3_Intron	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		GAAGTGGAGGCCATTCTGCTT	0.438000													32	12					0	0	0.080422	0	0
ZNF536	9745	broad.mit.edu	37	19	31039132	31039132	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:31039132A>T	ENST00000355537.3	+	4	2753	c.2606A>T	c.(2605-2607)cAc>cTc	p.H869L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	869					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TCTGGAGATCACTCGGGGCAG	0.582000													24	60					0	0	0.027356	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64601146	64601146	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:64601146C>T	ENST00000498707.1	-	21	3382	c.3040G>A	c.(3040-3042)Gac>Aac	p.D1014N	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.D986N	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1014	TSP type-1 4.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GTCCCACCGTCACAGCTTTTT	0.403000													20	13					0	0	0.018920	0	0
NPAS3	64067	broad.mit.edu	37	14	34247779	34247779	+	Splice_Site	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:34247779G>T	ENST00000346562.2	+	8	1131		c.e8+1		NPAS3_ENST00000548645.1_Splice_Site|NPAS3_ENST00000551492.1_Splice_Site|NPAS3_ENST00000357798.5_Splice_Site|NPAS3_ENST00000356141.4_Splice_Site	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CACTTGGACTGTAAGTACCTC	0.488000													20	46					2.39556e-15	2.8422e-15	0.076483	1	0
DENND1C	79958	broad.mit.edu	37	19	6475302	6475302	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:6475302C>T	ENST00000381480.2	-	14	1148	c.1036G>A	c.(1036-1038)Gca>Aca	p.A346T	DENND1C_ENST00000543576.1_Missense_Mutation_p.A302T	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	346	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						CAGACGAGTGCGTCGCGGTAC	0.657000													7	21					0	0	0.069234	0	0
C12orf71	728858	broad.mit.edu	37	12	27234319	27234319	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:27234319C>T	ENST00000429849.2	-	2	628	c.598G>A	c.(598-600)Gac>Aac	p.D200N		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	200										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						GAAGGAGTGTCATCCTTCTCT	0.562000													38	34					0	0	0.027894	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627461	21627461	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:21627461G>T	ENST00000425654.2	+	19	2808	c.2328G>T	c.(2326-2328)cgG>cgT	p.R776R	CNKSR2_ENST00000279451.4_Silent_p.R806R|CNKSR2_ENST00000379510.3_Silent_p.R806R|CNKSR2_ENST00000543067.1_Silent_p.R757R	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	806					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AGCACAGGCGGCAGTCTACCC	0.547000													32	16					8.16721e-17	9.874e-17	0.045705	1	0
PDE4C	5143	broad.mit.edu	37	19	18331046	18331046	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:18331046C>A	ENST00000355502.3	-	11	1663	c.792G>T	c.(790-792)cgG>cgT	p.R264R	PDE4C_ENST00000539010.1_Silent_p.R33R|PDE4C_ENST00000594617.2_Silent_p.R264R|PDE4C_ENST00000262805.11_Silent_p.R232R|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000594465.2_Silent_p.R264R|PDE4C_ENST00000447275.2_Silent_p.R158R			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	264					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	CCAGGAAGGTCCGGGAGATGT	0.542000													74	169					8.20938e-55	1.11368e-54	0.048971	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110397764	110397764	+	Splice_Site	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:110397764A>T	ENST00000378402.5	+	6	579		c.e6-1			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTTTGTTTTCAGGTACACTAA	0.338000										HNSCC(38;0.096)			4	16					0	0	0.014758	0	0
ASXL2	55252	broad.mit.edu	37	2	25973043	25973043	+	Nonsense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:25973043G>C	ENST00000435504.4	-	12	1675	c.1382C>G	c.(1381-1383)tCa>tGa	p.S461*	ASXL2_ENST00000272341.4_Nonsense_Mutation_p.S201*|ASXL2_ENST00000336112.4_Nonsense_Mutation_p.S433*|ASXL2_ENST00000404843.1_Nonsense_Mutation_p.S201*			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGGGCTCTGAAGATGTGGA	0.483000													86	144					0	0	0.048971	0	0
BRSK1	84446	broad.mit.edu	37	19	55816287	55816287	+	Splice_Site	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:55816287G>T	ENST00000309383.1	+	14	1993	c.1717_splice	c.e14+1	p.Q572_splice	BRSK1_ENST00000590333.1_Splice_Site_p.Q588_splice|BRSK1_ENST00000326848.7_Splice_Site_p.Q267_splice|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	572					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCAAGATGCAGGGTATGGGGG	0.627000													21	48					7.92952e-12	9.09945e-12	0.021523	1	0
PCDHA7	56141	broad.mit.edu	37	5	140216280	140216280	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140216280C>T	ENST00000525929.1	+	1	2312	c.2312C>T	c.(2311-2313)gCc>gTc	p.A771V	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.A771V	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCTCATGGCCTTCAGTCCC	0.522000													16	42					0	0	0.049695	0	0
THEMIS	387357	broad.mit.edu	37	6	128134640	128134640	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:128134640G>T	ENST00000368250.1	-	5	1407	c.909C>A	c.(907-909)tcC>tcA	p.S303S	THEMIS_ENST00000543064.1_Silent_p.S382S|THEMIS_ENST00000368248.2_Silent_p.S382S|THEMIS_ENST00000537166.1_Silent_p.S347S			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	382	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CAACAGATACGGATGACAGCT	0.488000													22	45					2.79863e-10	3.16485e-10	0.024334	1	0
KIAA1429	25962	broad.mit.edu	37	8	95541319	95541319	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:95541319C>T	ENST00000297591.5	-	7	934	c.859G>A	c.(859-861)Gaa>Aaa	p.E287K	KIAA1429_ENST00000437199.1_Missense_Mutation_p.E287K|KIAA1429_ENST00000421249.2_Missense_Mutation_p.E287K	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	287	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tcatcctcttcaccttcttcc	0.418000													9	29					0	0	0.069234	0	0
DENND3	22898	broad.mit.edu	37	8	142178212	142178212	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:142178212G>A	ENST00000519811.1	+	13	1933	c.1863G>A	c.(1861-1863)ctG>ctA	p.L621L	DENND3_ENST00000424248.1_Silent_p.L489L|DENND3_ENST00000262585.2_Silent_p.L541L			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	541										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTCCATGCTGAGCGAGGCCA	0.557000													46	110					0	0	0.048971	0	0
DYTN	391475	broad.mit.edu	37	2	207527684	207527684	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:207527684C>G	ENST00000452335.2	-	11	1692	c.1576G>C	c.(1576-1578)Gaa>Caa	p.E526Q		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	526	Poly-Glu.					plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TCTTGCAGTTCCTCTTCCTCC	0.453000													38	106					0	0	0.042209	0	0
NLRP12	91662	broad.mit.edu	37	19	54313954	54313954	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:54313954G>T	ENST00000324134.6	-	3	1127	c.959C>A	c.(958-960)aCg>aAg	p.T320K	NLRP12_ENST00000535162.1_Missense_Mutation_p.T320K|NLRP12_ENST00000391772.1_Missense_Mutation_p.T320K|NLRP12_ENST00000391773.1_Missense_Mutation_p.T320K|NLRP12_ENST00000391775.3_Missense_Mutation_p.T320K|NLRP12_ENST00000354278.3_Missense_Mutation_p.T320K|NLRP12_ENST00000351894.4_Missense_Mutation_p.T320K|NLRP12_ENST00000345770.5_Missense_Mutation_p.T320K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	320	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAGCAGCTCCGTGGGCCGTTT	0.567000													21	25					3.62473e-10	4.09244e-10	0.062417	1	0
LRP1	4035	broad.mit.edu	37	12	57559724	57559724	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:57559724C>G	ENST00000243077.3	+	16	3133	c.2667C>G	c.(2665-2667)ctC>ctG	p.L889L		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	889	LDL-receptor class A 3.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCCAGCCCTCTGCCGTGAGT	0.647000													23	42					0	0	0.034045	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41778021	41778021	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:41778021C>T	ENST00000392006.3	+	3	626	c.453C>T	c.(451-453)acC>acT	p.T151T	HNRNPUL1_ENST00000352456.3_Silent_p.T51T|HNRNPUL1_ENST00000378215.4_Silent_p.T108T|HNRNPUL1_ENST00000263367.3_Silent_p.T62T|HNRNPUL1_ENST00000594207.1_3'UTR|HNRNPUL1_ENST00000593587.1_Silent_p.T51T|HNRNPUL1_ENST00000595018.1_Silent_p.T51T|HNRNPUL1_ENST00000602130.1_Silent_p.T151T	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	151					nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						GAGCACCCACCAGCTTCCTCC	0.502000													58	103					0	0	0.048971	0	0
GRIP1	23426	broad.mit.edu	37	12	66765480	66765480	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:66765480C>T	ENST00000359742.4	-	23	3246	c.3006G>A	c.(3004-3006)ctG>ctA	p.L1002L	GRIP1_ENST00000286445.7_Silent_p.L987L|GRIP1_ENST00000398016.3_Silent_p.L950L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	1002					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TGACCTTGTGCAGCTCCACAG	0.468000													30	80					0	0	0.037714	0	0
LPPR3	79948	broad.mit.edu	37	19	814446	814446	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:814446G>T	ENST00000359894.2	-	6	966	c.903C>A	c.(901-903)atC>atA	p.I301I	LPPR3_ENST00000520876.3_Silent_p.I273I	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		273						integral to membrane	phosphatidate phosphatase activity										GGTAGGCAGCGATGCCCGCCC	0.667000													9	15					2.68362e-12	3.08462e-12	0.013537	1	0
PHIP	55023	broad.mit.edu	37	6	79655973	79655973	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:79655973C>T	ENST00000275034.4	-	38	4542	c.4375G>A	c.(4375-4377)Gaa>Aaa	p.E1459K	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1459					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTTTTCCTTTCAGGGCTGTAA	0.343000													31	67					0	0	0.050027	0	0
TRANK1	9881	broad.mit.edu	37	3	36896758	36896758	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:36896758G>A	ENST00000301807.6	-	12	4570	c.2673C>T	c.(2671-2673)ttC>ttT	p.F891F	TRANK1_ENST00000429976.2_Silent_p.F1441F|TRANK1_ENST00000428977.2_Silent_p.F891F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1441					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGGCATAATGGAACAGAGAGC	0.537000													29	33					0	0	0.034045	0	0
VIPR2	7434	broad.mit.edu	37	7	158829540	158829540	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:158829540G>T	ENST00000262178.2	-	7	836	c.651C>A	c.(649-651)ttC>ttA	p.F217L	VIPR2_ENST00000402066.1_Missense_Mutation_p.F358L|VIPR2_ENST00000377633.3_Missense_Mutation_p.F201L	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	217					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GCAGCCAGAAGAAGTTGGCCA	0.587000													22	65					7.33532e-06	7.77988e-06	0.021523	1	0
C2CD5	9847	broad.mit.edu	37	12	22646262	22646262	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:22646262T>A	ENST00000333957.4	-	11	1412	c.1157A>T	c.(1156-1158)gAa>gTa	p.E386V	C2CD5_ENST00000446597.1_Missense_Mutation_p.E386V|C2CD5_ENST00000536386.1_Missense_Mutation_p.E388V|C2CD5_ENST00000545552.1_Missense_Mutation_p.E399V|C2CD5_ENST00000544930.1_Missense_Mutation_p.E201V|C2CD5_ENST00000542676.1_Missense_Mutation_p.E386V|C2CD5_ENST00000396028.2_Missense_Mutation_p.E377V	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ATCTCGAGTTTCTGGTTCATC	0.328000													34	45					0	0	0.080422	0	0
LARP4B	23185	broad.mit.edu	37	10	871104	871104	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:871104G>A	ENST00000316157.3	-	12	1425	c.1385C>T	c.(1384-1386)aCa>aTa	p.T462I		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	462							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						TTGAATCCGTGTTCTAGTTTG	0.493000													54	86					0	0	0.048971	0	0
NUF2	83540	broad.mit.edu	37	1	163298026	163298026	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:163298026G>C	ENST00000271452.3	+	4	486	c.207G>C	c.(205-207)gtG>gtC	p.V69V	NUF2_ENST00000490881.1_3'UTR|NUF2_ENST00000524800.1_Silent_p.V69V|NUF2_ENST00000367900.3_Silent_p.V69V	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	69	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					AGATGCCAGTGAACTCTGAAG	0.323000													50	49					0	0	0.048971	0	0
LIPG	9388	broad.mit.edu	37	18	47091756	47091756	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:47091756C>G	ENST00000261292.4	+	2	445	c.167C>G	c.(166-168)tCc>tGc	p.S56C	LIPG_ENST00000577628.1_Missense_Mutation_p.S92C|LIPG_ENST00000580036.1_Missense_Mutation_p.S56C|LIPG_ENST00000427224.2_Missense_Mutation_p.S56C	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	56					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						CTCCGCACCTCCAAGGACCCA	0.507000													20	29					0	0	0.062417	0	0
IGKV3-7	28915	broad.mit.edu	37	2	89278144	89278144	+	RNA	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:89278144G>A	ENST00000390247.2	-	0	287																											GAGCCTGGGCGCCTGGCCAGG	0.577000													15	58					0	0	0.033300	0	0
MARVELD2	153562	broad.mit.edu	37	5	68728870	68728870	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:68728870G>C	ENST00000325631.5	+	5	1527	c.1453G>C	c.(1453-1455)Gag>Cag	p.E485Q	MARVELD2_ENST00000413223.2_Missense_Mutation_p.E369Q	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	485					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		GAAGTTTGATGAGCTGGATGC	0.473000													52	62					0	0	0.048971	0	0
OR10A2	341276	broad.mit.edu	37	11	6891617	6891617	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:6891617C>A	ENST00000307322.4	+	1	694	c.632C>A	c.(631-633)gCc>gAc	p.A211D		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATTGCTGCTGCCATCCTCAAG	0.453000													46	82					4.88482e-21	6.12792e-21	0.048971	1	0
NBEA	26960	broad.mit.edu	37	13	35926326	35926326	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:35926326A>C	ENST00000540320.1	+	38	6579	c.6045A>C	c.(6043-6045)agA>agC	p.R2015S	NBEA_ENST00000310336.4_Missense_Mutation_p.R2015S|NBEA_ENST00000379939.2_Missense_Mutation_p.R2012S|NBEA_ENST00000400445.3_Missense_Mutation_p.R2015S			Q8NFP9	NBEA_HUMAN	neurobeachin	2015						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTGATAGAAGAGAGGAAGAAA	0.338000													7	7					0	0	0.058154	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													6	179					0	0	0.029380	0	0
UNC5D	137970	broad.mit.edu	37	8	35606111	35606111	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:35606111C>G	ENST00000287272.2	+	11	1646	c.1626C>G	c.(1624-1626)atC>atG	p.I542M	UNC5D_ENST00000404895.2_Missense_Mutation_p.I611M|UNC5D_ENST00000449677.1_Missense_Mutation_p.I187M|UNC5D_ENST00000453357.2_Missense_Mutation_p.I606M|UNC5D_ENST00000420357.1_Missense_Mutation_p.I544M|UNC5D_ENST00000416672.1_Missense_Mutation_p.I616M			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	611	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CAGACATGATCGTCACCACTC	0.493000													38	45					0	0	0.030466	0	0
CCDC17	149483	broad.mit.edu	37	1	46085982	46085982	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:46085982G>A	ENST00000421127.2	-	13	1950	c.1807C>T	c.(1807-1809)Cac>Tac	p.H603Y	CCDC17_ENST00000343901.2_Missense_Mutation_p.H580Y|CCDC17_ENST00000528266.1_Missense_Mutation_p.H612Y|CCDC17_ENST00000445048.2_Missense_Mutation_p.H100Y	NM_001114938.2|NM_001190182.1	NP_001108410.2|NP_001177111.1	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	612										kidney(1)|large_intestine(1)|lung(1)|ovary(2)	5	Acute lymphoblastic leukemia(166;0.155)					GAACTGTGGTGAGGGCCCAAA	0.552000													7	24					0	0	0.047766	0	0
RAI2	10742	broad.mit.edu	37	X	17820121	17820121	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:17820121G>C	ENST00000545871.1	-	3	470	c.10C>G	c.(10-12)Ctg>Gtg	p.L4V	RP3-389A20.4_ENST00000509491.2_Missense_Mutation_p.L4V|RAI2_ENST00000360011.1_Missense_Mutation_p.L4V|RAI2_ENST00000451717.1_Missense_Mutation_p.L4V|RAI2_ENST00000331511.1_Missense_Mutation_p.L4V|RAI2_ENST00000415486.3_Missense_Mutation_p.L4V	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	4					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					TGGGACTGCAGGTCGTCCATC	0.488000													79	38					0	0	0.048971	0	0
OGDHL	55753	broad.mit.edu	37	10	50957830	50957830	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:50957830C>A	ENST00000374103.4	-	8	1014	c.929G>T	c.(928-930)cGc>cTc	p.R310L	OGDHL_ENST00000419399.1_Missense_Mutation_p.R253L|OGDHL_ENST00000432695.1_Missense_Mutation_p.R101L	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	310					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CAGGTCCTTGCGGATCACGTT	0.672000													11	14					1.08611e-07	1.18608e-07	0.010729	1	0
ZPLD1	131368	broad.mit.edu	37	3	102187849	102187849	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:102187849G>A	ENST00000306176.1	+	8	951	c.851G>A	c.(850-852)cGa>cAa	p.R284Q	ZPLD1_ENST00000466937.1_Missense_Mutation_p.R268Q|ZPLD1_ENST00000491959.1_Missense_Mutation_p.R268Q	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	268	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GAGAATGGCCGAAGCCAGCGG	0.478000													14	60					0	0	0.028581	0	0
ACVR1C	130399	broad.mit.edu	37	2	158390463	158390463	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:158390463A>G	ENST00000243349.7	-	9	1809	c.1449T>C	c.(1447-1449)tcT>tcC	p.S483S	ACVR1C_ENST00000348328.5_Silent_p.S326S|ACVR1C_ENST00000335450.7_Silent_p.S403S|ACVR1C_ENST00000409680.3_Silent_p.S433S	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	483	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						CACAAAGTTGAGATATAGTCT	0.403000													30	56					0	0	0.045705	0	0
MNX1	3110	broad.mit.edu	37	7	156799175	156799175	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:156799175G>C	ENST00000252971.6	-	2	1150	c.850C>G	c.(850-852)Cag>Gag	p.Q284E	MNX1_ENST00000469500.1_Intron|RP5-1121A15.4_ENST00000429228.1_RNA|MNX1_ENST00000543409.1_Missense_Mutation_p.Q72E	NM_005515.3	NP_005506.3	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1	284					humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGCGCACCTGGGTCTCGGTG	0.662000													13	21					0	0	0.033300	0	0
OR5D13	390142	broad.mit.edu	37	11	55541372	55541372	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55541372G>T	ENST00000361760.1	+	1	459	c.459G>T	c.(457-459)tgG>tgT	p.W153C		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				CCTATACATGGGGGATAGTGT	0.408000													40	122					3.68427e-32	4.84772e-32	0.039052	1	0
MPO	4353	broad.mit.edu	37	17	56356990	56356990	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:56356990G>T	ENST00000340482.3	-	4	618	c.442C>A	c.(442-444)Cag>Aag	p.Q148K	MPO_ENST00000225275.3_Missense_Mutation_p.Q148K			P05164	PERM_HUMAN	myeloperoxidase	148					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	ACATTCAGCTGGGCGGGCGTC	0.617000													40	24					6.34439e-16	7.61762e-16	0.048971	1	0
VIL1	7429	broad.mit.edu	37	2	219299291	219299291	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:219299291A>G	ENST00000248444.5	+	14	1631	c.1543A>G	c.(1543-1545)Aca>Gca	p.T515A	VIL1_ENST00000392114.2_Missense_Mutation_p.T204A	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	515	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGGCCCTCCACACGGCTGTT	0.557000													28	75					0	0	0.054565	0	0
SRRT	51593	broad.mit.edu	37	7	100485997	100485997	+	Missense_Mutation	SNP	C	C	T	rs139519950		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:100485997C>T	ENST00000388793.4	+	19	2765	c.2545C>T	c.(2545-2547)Cgc>Tgc	p.R849C	SRRT_ENST00000432932.1_Missense_Mutation_p.R845C|SRRT_ENST00000457580.2_Missense_Mutation_p.R846C|SRRT_ENST00000347433.4_Missense_Mutation_p.R850C	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	850					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TGGGAAACCTCGCAACAGGTG	0.602000													3	33					0	0	0.004672	0	0
MYH7B	57644	broad.mit.edu	37	20	33588488	33588488	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:33588488C>T	ENST00000262873.7	+	37	5392	c.5300C>T	c.(5299-5301)tCg>tTg	p.S1767L		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1725						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTTCTGCATTCGCAGGTGGGG	0.662000													4	9					0	0	0.021553	0	0
C3orf30	152405	broad.mit.edu	37	3	118867070	118867070	+	Missense_Mutation	SNP	G	G	C	rs138537972		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:118867070G>C	ENST00000295622.1	+	2	1482	c.1442G>C	c.(1441-1443)cGc>cCc	p.R481P	RP11-484M3.5_ENST00000490594.1_Intron	NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	481										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		TATCATATACGCAATCAAACT	0.368000													55	49					0	0	0.048971	0	0
OR4A16	81327	broad.mit.edu	37	11	55111087	55111087	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55111087G>C	ENST00000314721.2	+	1	461	c.411G>C	c.(409-411)ctG>ctC	p.L137L		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TGAATCGACTGGTTTGCATCC	0.473000													29	60					0	0	0.041601	0	0
SND1	27044	broad.mit.edu	37	7	127342491	127342491	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:127342491A>G	ENST00000354725.3	+	6	786	c.592A>G	c.(592-594)Atc>Gtc	p.I198V		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	198	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						TCACACAGCTATCATCGAGCA	0.488000													50	138					0	0	0.048971	0	0
LGALS12	85329	broad.mit.edu	37	11	63283785	63283785	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:63283785A>T	ENST00000415491.2	+	8	1362	c.748A>T	c.(748-750)Agc>Tgc	p.S250C	LGALS12_ENST00000340246.5_Missense_Mutation_p.S312C|LGALS12_ENST00000425950.2_Missense_Mutation_p.S241C|LGALS12_ENST00000394618.3_Missense_Mutation_p.S311C|LGALS12_ENST00000255684.5_Missense_Mutation_p.S302C	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	311	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GGGGGCCACCAGCATGAACCA	0.622000													28	44					0	0	0.041601	0	0
SIK2	23235	broad.mit.edu	37	11	111592583	111592583	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:111592583C>T	ENST00000304987.3	+	13	2147	c.1974C>T	c.(1972-1974)gtC>gtT	p.V658V		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	658					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.V658V(1)		breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						AGGAAAGCGTCTCCACTCTCC	0.567000													28	42					0	0	0.069456	0	0
FBXO5	26271	broad.mit.edu	37	6	153296105	153296105	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:153296105C>T	ENST00000367241.3	-	2	997	c.617G>A	c.(616-618)cGa>cAa	p.R206Q	FBXO5_ENST00000229758.3_Missense_Mutation_p.R252Q	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	252	Interaction with EVI5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		GAGTCCCCTTCGAAAGAGTTC	0.358000													35	72					0	0	0.033182	0	0
TRPV1	7442	broad.mit.edu	37	17	3477008	3477008	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:3477008G>A	ENST00000174621.6	-	12	2305	c.2016C>T	c.(2014-2016)ctC>ctT	p.L672L	TRPV1_ENST00000425167.2_Silent_p.L685L|SHPK_ENST00000572705.1_Silent_p.L674L|TRPV1_ENST00000399759.3_Silent_p.L674L|TRPV1_ENST00000399756.4_Silent_p.L674L|TRPV1_ENST00000310522.5_Silent_p.L614L|TRPV1_ENST00000576351.1_Silent_p.L664L|TRPV1_ENST00000571088.1_Silent_p.L674L			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	674					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	TGTTGAGCAGGAGGATGTAGG	0.532000													21	21					0	0	0.076483	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20885847	20885847	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:20885847C>T	ENST00000381552.1	+	10	1559	c.1191C>T	c.(1189-1191)ctC>ctT	p.L397L	SLCO1C1_ENST00000540354.1_Silent_p.L348L|SLCO1C1_ENST00000545102.1_Silent_p.L279L|SLCO1C1_ENST00000545604.1_Silent_p.L397L|SLCO1C1_ENST00000266509.2_Silent_p.L397L			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	397					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TCTCAGGGCTCATCAACATTC	0.353000													24	17					0	0	0.034045	0	0
CYP2D6	1565	broad.mit.edu	37	22	42525130	42525130	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:42525130G>A	ENST00000360608.5	-	3	524	c.410C>T	c.(409-411)tCc>tTc	p.S137F	NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000359033.4_Intron|CYP2D6_ENST00000389970.3_Missense_Mutation_p.S137F|NDUFA6-AS1_ENST00000439129.1_RNA	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	137							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCGCAAGGTGGAGACGGAGAA	0.687000													16	41					0	0	0.028581	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39279911	39279911	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:39279911C>A	ENST00000394014.1	-	1	508	c.464G>T	c.(463-465)tGc>tTc	p.C155F		NM_031854.2	NP_114060.1	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	155	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ggattcacagcaagaggggca	0.652000													3	43					0.00909568	0.00928131	0.009096	1	0
KCTD5	54442	broad.mit.edu	37	16	2752431	2752431	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:2752431G>T	ENST00000564195.1	+	4	544	c.535G>T	c.(535-537)Gca>Tca	p.A179S	KCTD5_ENST00000301738.4_Silent_p.L209L			Q9NXV2	KCTD5_HUMAN	potassium channel tetramerization domain containing 5	0					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2						CCAAGGAGCTGCACAACACCC	0.612000													23	90					4.87955e-14	5.6739e-14	0.027356	1	0
SLC25A40	55972	broad.mit.edu	37	7	87479232	87479232	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:87479232C>A	ENST00000341119.5	-	6	642	c.296G>T	c.(295-297)gGc>gTc	p.G99V		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	99					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					AGATTTAATGCCCTCATTTCG	0.254000													8	66					0.0581538	0.0586565	0.058154	1	0
PAICS	10606	broad.mit.edu	37	4	57314715	57314715	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:57314715A>G	ENST00000514888.1	+	5	764	c.249A>G	c.(247-249)atA>atG	p.I83M	PAICS_ENST00000264221.2_Missense_Mutation_p.I175M|PAICS_ENST00000399688.3_Missense_Mutation_p.I182M|PAICS_ENST00000512576.1_Missense_Mutation_p.I175M			P22234	PUR6_HUMAN	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	175	SAICAR synthetase.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|identical protein binding|phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity			endometrium(1)|kidney(2)|large_intestine(1)|urinary_tract(1)	5	Glioma(25;0.08)|all_neural(26;0.101)				L-Aspartic Acid(DB00128)	TATTTGAAATACTGGAGAAAT	0.383000													4	8					0	0	0.009096	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7662787	7662787	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:7662787C>A	ENST00000299492.4	+	16	1841	c.1453C>A	c.(1453-1455)Cct>Act	p.P485T	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.P342T|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.P327T|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.P373T	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	485					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGAATCAGGTCCTCAGTCTCC	0.473000													28	69					1.12875e-08	1.25417e-08	0.030593	1	0
OR2F2	135948	broad.mit.edu	37	7	143632716	143632716	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:143632716C>T	ENST00000408955.2	+	1	458	c.391C>T	c.(391-393)Cga>Tga	p.R131*		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					TGACCGCCTGCGATACTCGGC	0.552000													36	107					0	0	0.074837	0	0
ADAM19	8728	broad.mit.edu	37	5	156920137	156920137	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:156920137G>C	ENST00000257527.4	-	16	1830	c.1752C>G	c.(1750-1752)ccC>ccG	p.P584P	ADAM19_ENST00000517905.1_Silent_p.P584P|ADAM19_ENST00000430702.2_Silent_p.P317P|ADAM19_ENST00000394020.1_Silent_p.P586P	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	584	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGACTCCAGGGGCCGGGCCT	0.597000													33	105					0	0	0.033182	0	0
ARID2	196528	broad.mit.edu	37	12	46245869	46245869	+	Silent	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:46245869A>T	ENST00000334344.6	+	15	4135	c.3963A>T	c.(3961-3963)ctA>ctT	p.L1321L	ARID2_ENST00000422737.1_Silent_p.L1172L|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Silent_p.L931L	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1321					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGTGCTCACTAATCAGTAATG	0.393000			"""N, S, F"""		hepatocellular carcinoma								15	57					0	0	0.055883	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175601	140175601	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140175601C>T	ENST00000526136.1	+	1	1052	c.1052C>T	c.(1051-1053)tCa>tTa	p.S351L	PCDHA2_ENST00000378132.1_Missense_Mutation_p.S351L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.S351L	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGAAGTCTCAATAACGTCT	0.453000													21	40					0	0	0.076483	0	0
FIG4	9896	broad.mit.edu	37	6	110056358	110056358	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:110056358G>T	ENST00000230124.3	+	6	627	c.503G>T	c.(502-504)aGc>aTc	p.S168I	FIG4_ENST00000441478.2_Missense_Mutation_p.S22I|FIG4_ENST00000368941.1_Missense_Mutation_p.S91I	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	168	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTCAGTTACAGCTATGATTTG	0.368000													24	72					3.08376e-08	3.41016e-08	0.018920	1	0
STAB2	55576	broad.mit.edu	37	12	104056698	104056698	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:104056698G>A	ENST00000388887.2	+	18	2148	c.1944G>A	c.(1942-1944)ctG>ctA	p.L648L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	648	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TTTACACACTGACAGGAGTTC	0.413000													56	46					0	0	0.048971	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161024435	161024435	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:161024435C>T	ENST00000368013.3	-	4	726	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.E136K|ARHGAP30_ENST00000368015.1_Intron	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	136	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ACAGGGAGTTCCCGAAGCACC	0.522000													33	127					0	0	0.036044	0	0
LAMA4	3910	broad.mit.edu	37	6	112476086	112476086	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:112476086G>A	ENST00000230538.7	-	16	2420	c.2023C>T	c.(2023-2025)Caa>Taa	p.Q675*	LAMA4_ENST00000424408.2_Nonsense_Mutation_p.Q668*|RP1-142L7.5_ENST00000425503.1_RNA|RP1-142L7.5_ENST00000588689.1_RNA|RP1-142L7.5_ENST00000585373.1_RNA|LAMA4_ENST00000522006.1_Nonsense_Mutation_p.Q668*|LAMA4_ENST00000389463.4_Nonsense_Mutation_p.Q668*	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	675	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.Q668E(1)		NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCTCTGGCTTGATTGAGGAGG	0.398000													22	77					0	0	0.024334	0	0
DHX16	8449	broad.mit.edu	37	6	30639018	30639018	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:30639018G>T	ENST00000376442.3	-	2	436	c.241C>A	c.(241-243)Cgg>Agg	p.R81R		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	81					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						TCTGCTGCCCGAGCTGGCTTT	0.557000													112	282					8.84652e-70	1.20244e-69	0.048971	1	0
ZNF280B	140883	broad.mit.edu	37	22	22842707	22842707	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:22842707C>A	ENST00000360412.2	-	4	1792	c.1017G>T	c.(1015-1017)tgG>tgT	p.W339C	ZNF280B_ENST00000406426.1_Missense_Mutation_p.W339C	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TGTGGTTTTCCCAGCTGTCGT	0.483000													80	32					1.63549e-45	2.20162e-45	0.048971	1	0
LPHN2	23266	broad.mit.edu	37	1	82450289	82450289	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:82450289G>C	ENST00000370728.1	+	22	3938	c.3293G>C	c.(3292-3294)tGc>tCc	p.C1098S	LPHN2_ENST00000370730.1_Missense_Mutation_p.C1098S|LPHN2_ENST00000370727.1_Missense_Mutation_p.C1113S|LPHN2_ENST00000370725.1_Missense_Mutation_p.C1113S|LPHN2_ENST00000370717.2_Missense_Mutation_p.C1113S|LPHN2_ENST00000370713.1_Missense_Mutation_p.C1085S|LPHN2_ENST00000394879.1_Missense_Mutation_p.C1100S|LPHN2_ENST00000319517.6_Missense_Mutation_p.C1085S|LPHN2_ENST00000271029.4_Missense_Mutation_p.C1113S|LPHN2_ENST00000335786.5_Missense_Mutation_p.C1098S|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370721.1_Missense_Mutation_p.C1023S|LPHN2_ENST00000370723.1_Missense_Mutation_p.C1100S|LPHN2_ENST00000359929.3_Missense_Mutation_p.C1085S|LPHN2_ENST00000370715.1_Missense_Mutation_p.C1085S			O95490	LPHN2_HUMAN	latrophilin 2	1098					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TATGGCAAGTGCTTCAGACAC	0.453000													35	76					0	0	0.080422	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846746	47846746	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:47846746C>A	ENST00000339488.4	-	3	1867	c.1834G>T	c.(1834-1836)Gcc>Tcc	p.A612S		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	612						integral to membrane	hedgehog receptor activity										CTAGTCCTGGCCACCAGATAC	0.438000													17	36					1.15088e-07	1.25485e-07	0.028581	1	0
DENND4B	9909	broad.mit.edu	37	1	153907303	153907303	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:153907303C>T	ENST00000361217.4	-	18	3124	c.2706G>A	c.(2704-2706)caG>caA	p.Q902Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	902	Gln-rich.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgttgctgct	0.642000													4	72					0	0	0.009096	0	0
CYP2D6	1565	broad.mit.edu	37	22	42524885	42524885	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:42524885G>A	ENST00000360608.5	-	4	681	c.567C>T	c.(565-567)ctC>ctT	p.L189L	NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000359033.4_Silent_p.L138L|CYP2D6_ENST00000389970.3_Silent_p.L189L|NDUFA6-AS1_ENST00000439129.1_RNA	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	189							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCCCGCAGGTGAGGGAGGCGA	0.662000													4	0					0	0	0.021553	0	0
CACFD1	11094	broad.mit.edu	37	9	136330483	136330483	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:136330483C>T	ENST00000316948.4	+	3	314	c.234C>T	c.(232-234)ttC>ttT	p.F78F	CACFD1_ENST00000489519.1_3'UTR|CACFD1_ENST00000540581.1_Silent_p.F78F|CACFD1_ENST00000291722.7_Intron|CACFD1_ENST00000542192.1_Intron	NM_017586.3	NP_060056.1	Q9UGQ2	FLOWR_HUMAN	calcium channel flower domain containing 1	78						integral to membrane											AGGCGCCCTTCTGCTGCCAGT	0.602000													297	73					0	0	0.048971	0	0
ERCC4	2072	broad.mit.edu	37	16	14026137	14026137	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:14026137G>T	ENST00000311895.7	+	6	1106	c.1097G>T	c.(1096-1098)gGg>gTg	p.G366V	CTD-2135D7.2_ENST00000570663.1_RNA|CTD-2135D7.2_ENST00000575137.1_RNA|ERCC4_ENST00000575156.1_Missense_Mutation_p.G366V	NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	366					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						ATTAAAGAAGGGGAAGGTATC	0.323000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				33	37					3.33393e-15	3.94215e-15	0.074837	1	0
ZNF768	79724	broad.mit.edu	37	16	30537139	30537139	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:30537139C>A	ENST00000380412.5	-	2	497	c.322G>T	c.(322-324)Gat>Tat	p.D108Y	ZNF768_ENST00000562803.1_Missense_Mutation_p.D77Y	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	108	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CTCTGAGAATCTGATTCAGGG	0.597000													19	67					6.21321e-17	7.52465e-17	0.076483	1	0
MYO19	80179	broad.mit.edu	37	17	34883390	34883390	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:34883390G>C	ENST00000431794.3	-	5	814	c.292C>G	c.(292-294)Cag>Gag	p.Q98E	MYO19_ENST00000544606.1_Intron|MYO19_ENST00000586007.1_Missense_Mutation_p.Q98E|MYO19_ENST00000268852.9_Missense_Mutation_p.Q98E	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	98	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACCTGGGGCTGAGGCGCAGCA	0.572000													8	24					0	0	0.069234	0	0
MUC16	94025	broad.mit.edu	37	19	9049135	9049135	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:9049135G>A	ENST00000397910.4	-	5	32699	c.32496C>T	c.(32494-32496)agC>agT	p.S10832S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10834	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTGTTGGGCTGGTCTGTG	0.483000													44	89					0	0	0.048971	0	0
BCL9	607	broad.mit.edu	37	1	147084819	147084819	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:147084819G>T	ENST00000234739.3	+	5	931	c.191G>T	c.(190-192)tGt>tTt	p.C64F	BCL9_ENST00000473292.1_Intron	NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	64					Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CCATCCCCCTGTGACTCCAAG	0.597000			T	"""IGH@, IGL@"""	B-ALL								7	29					8.12818e-05	8.53033e-05	0.029380	1	0
DOCK6	57572	broad.mit.edu	37	19	11347230	11347230	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:11347230G>A	ENST00000294618.7	-	20	2195	c.2184C>T	c.(2182-2184)ttC>ttT	p.F728F	DOCK6_ENST00000319867.7_Silent_p.F32F	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	728	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GCACCAGGGTGAAGAATTTGT	0.617000													4	12					0	0	0.009096	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842708	22842708	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:22842708C>A	ENST00000360412.2	-	4	1791	c.1016G>T	c.(1015-1017)tGg>tTg	p.W339L	ZNF280B_ENST00000406426.1_Missense_Mutation_p.W339L	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GTGGTTTTCCCAGCTGTCGTT	0.483000													80	32					1.63549e-45	2.20162e-45	0.048971	1	0
RNF31	55072	broad.mit.edu	37	14	24617533	24617533	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:24617533G>A	ENST00000324103.6	+	3	726	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	RNF31_ENST00000559275.1_5'UTR|RNF31_ENST00000557878.1_3'UTR	NM_017999.4	NP_060469.4	Q96EP0	RNF31_HUMAN	ring finger protein 31	136	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(4)|skin(2)|soft_tissue(1)	39				GBM - Glioblastoma multiforme(265;0.00861)		GAGCTTCCCCGAAGGGCAGGA	0.567000													13	37					0	0	0.016723	0	0
AP3B2	8120	broad.mit.edu	37	15	83349890	83349890	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:83349890C>G	ENST00000261722.3	-	6	769	c.562G>C	c.(562-564)Gag>Cag	p.E188Q	RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Missense_Mutation_p.E156Q|AP3B2_ENST00000535359.1_Missense_Mutation_p.E188Q	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	188					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			AGAAGCTTCTCAATGACTTCT	0.582000													7	17					0	0	0.038147	0	0
APOA1	335	broad.mit.edu	37	11	116707841	116707841	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:116707841C>T	ENST00000236850.4	-	3	441	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	APOA1_ENST00000359492.2_Missense_Mutation_p.E26K|APOA1_ENST00000375329.2_Intron|APOA1_ENST00000375323.1_Missense_Mutation_p.E26K|AP006216.12_ENST00000444200.1_RNA|APOA1_ENST00000375320.1_Missense_Mutation_p.E26K	NM_000039.1	NP_000030.1	P02647	APOA1_HUMAN	apolipoprotein A-I	26					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding			cervix(1)|endometrium(1)|lung(4)|prostate(1)|skin(2)	9	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TGGGGGGGTTCATCTTGCTGC	0.602000													21	74					0	0	0.055883	0	0
IPMK	253430	broad.mit.edu	37	10	60027344	60027344	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:60027344G>A	ENST00000373935.3	-	1	350	c.28C>T	c.(28-30)Cgg>Tgg	p.R10W		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	10						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						GCCTCGACCCGGAGGGGGGAT	0.677000													5	5					0	0	0.038147	0	0
SOHLH1	402381	broad.mit.edu	37	9	138588565	138588565	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:138588565G>C	ENST00000298466.5	-	5	614	c.554C>G	c.(553-555)gCg>gGg	p.A185G	SOHLH1_ENST00000425225.1_Missense_Mutation_p.A185G	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	185					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CCTGGAGGACGCAAGGATGTG	0.657000													99	24					0	0	0.048971	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50667893	50667893	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:50667893C>G	ENST00000439308.2	-	4	1722	c.1230G>C	c.(1228-1230)ctG>ctC	p.L410L	TUBGCP6_ENST00000248846.5_Silent_p.L410L	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	410					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGAAATGACTCAGGCGCGTGT	0.587000													10	23					0	0	0.013537	0	0
CADM3	57863	broad.mit.edu	37	1	159170669	159170669	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:159170669G>A	ENST00000368125.4	+	9	1311	c.1154G>A	c.(1153-1155)gGc>gAc	p.G385D	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Missense_Mutation_p.G419D|CADM3_ENST00000497636.1_3'UTR	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	385					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					AATGCAGAAGGCGGGCAGTCA	0.607000													55	80					0	0	0.048971	0	0
AMELY	266	broad.mit.edu	37	Y	6736332	6736332	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrY:6736332G>A	ENST00000215479.5	-	5	386	c.319C>T	c.(319-321)Cag>Tag	p.Q107*	AMELY_ENST00000383037.4_Nonsense_Mutation_p.Q121*|AMELY_ENST00000383036.1_Nonsense_Mutation_p.Q121*	NM_001143.1	NP_001134.1	Q99218	AMELY_HUMAN	amelogenin, Y-linked	121	Gln-rich.				biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel			NS(1)|lung(5)	6						ATGGATTGCTGGCCAGGAACA	0.632000													53	20					0	0	0.048971	0	0
POLR1C	9533	broad.mit.edu	37	6	43488713	43488713	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:43488713C>T	ENST00000372389.3	+	8	937	c.849C>T	c.(847-849)ttC>ttT	p.F283F	POLR1C_ENST00000304004.3_Silent_p.F283F|POLR1C_ENST00000372344.2_Silent_p.F233F	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	283					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TGGATACCTTCAGCAGAGAAA	0.443000													34	81					0	0	0.064281	0	0
SALL1	6299	broad.mit.edu	37	16	51175993	51175993	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:51175993C>A	ENST00000251020.4	-	2	173	c.140G>T	c.(139-141)cGg>cTg	p.R47L	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000440970.1_5'UTR|SALL1_ENST00000566102.1_Intron	NM_002968.2	NP_002959.2	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	47					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGCACAGCACCGGCCACAGAC	0.443000													55	53					8.83742e-36	1.17832e-35	0.048971	1	0
NBEAL1	65065	broad.mit.edu	37	2	204078335	204078335	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:204078335G>A	ENST00000449802.1	+	54	8275	c.7942G>A	c.(7942-7944)Gat>Aat	p.D2648N		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2648							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						AGGTTTAGAAGATGGCAAATT	0.423000													50	94					0	0	0.048971	0	0
SLC4A8	9498	broad.mit.edu	37	12	51865142	51865142	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:51865142T>C	ENST00000453097.2	+	14	1947	c.1730T>C	c.(1729-1731)cTt>cCt	p.L577P	SLC4A8_ENST00000394856.1_Missense_Mutation_p.L524P|SLC4A8_ENST00000358657.3_Missense_Mutation_p.L604P|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000535225.2_Missense_Mutation_p.L524P|SLC4A8_ENST00000514353.3_Missense_Mutation_p.L524P	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	577					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGTATTGTCCTTGTGGCAACT	0.438000													40	77					0	0	0.025465	0	0
PLXNB2	23654	broad.mit.edu	37	22	50728234	50728234	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:50728234C>T	ENST00000449103.1	-	3	920	c.780G>A	c.(778-780)ctG>ctA	p.L260L	PLXNB2_ENST00000359337.4_Silent_p.L260L			O15031	PLXB2_HUMAN	plexin B2	260	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCCATCTCCAGGTAGGAGT	0.642000													29	42					0	0	0.074837	0	0
MPP6	51678	broad.mit.edu	37	7	24690293	24690293	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:24690293A>T	ENST00000396475.2	+	6	912	c.613A>T	c.(613-615)Atc>Ttc	p.I205F	MPP6_ENST00000222644.4_Missense_Mutation_p.I205F|MPP6_ENST00000409761.1_Missense_Mutation_p.I93F	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	205	PDZ.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						CACCCTAAAAATCTTACCAAG	0.303000													57	71					0	0	0.048971	0	0
AOX1	316	broad.mit.edu	37	2	201477456	201477456	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:201477456A>G	ENST00000374700.2	+	14	1629	c.1388A>G	c.(1387-1389)tAt>tGt	p.Y463C	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	463					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity	p.Y463C(1)		breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGCATCTCATATGGAGGCGTT	0.468000													19	49					0	0	0.062417	0	0
CCDC39	339829	broad.mit.edu	37	3	180378460	180378460	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:180378460C>A	ENST00000273654.4	-	10	1285	c.666G>T	c.(664-666)tgG>tgT	p.W222C	CCDC39_ENST00000442201.2_Missense_Mutation_p.W138C			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	138					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTTGCTGGTCCCAGTTCATTT	0.373000													10	11					3.07112e-06	3.26219e-06	0.010729	1	0
RSPO2	340419	broad.mit.edu	37	8	109001460	109001460	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:109001460G>A	ENST00000276659.5	-	3	727	c.107C>T	c.(106-108)tCa>tTa	p.S36L	RSPO2_ENST00000378439.2_Intron|RSPO2_ENST00000517781.1_Intron|RSPO2_ENST00000517939.1_5'UTR	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	36					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			AATGGGATTTGATACATAACT	0.353000													20	48					0	0	0.062417	0	0
CHRND	1144	broad.mit.edu	37	2	233399876	233399876	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:233399876G>A	ENST00000258385.3	+	12	1440	c.1408G>A	c.(1408-1410)Gac>Aac	p.D470N	CHRND_ENST00000543200.1_Missense_Mutation_p.D455N|CHRND_ENST00000457943.2_Missense_Mutation_p.D276N	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	470					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CCGCACAGTGGACCGCCTCTG	0.627000													38	114					0	0	0.033182	0	0
PDCD7	10081	broad.mit.edu	37	15	65411716	65411716	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:65411716G>A	ENST00000204549.4	-	4	1386	c.1332C>T	c.(1330-1332)atC>atT	p.I444I		NM_005707.1	NP_005698.1	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	444					apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex				endometrium(4)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	7						CCTCTGACCTGATCTGGATGA	0.473000													12	24					0	0	0.020292	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222831	140222831	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140222831C>G	ENST00000531613.1	+	1	1925	c.1925C>G	c.(1924-1926)tCt>tGt	p.S642C	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S642C	NM_018911.2	NP_061734.1												p.S642C(4)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCGGACTCTCCGCGCCAC	0.657000													57	139					0	0	0.048971	0	0
MCM3AP	8888	broad.mit.edu	37	21	47678951	47678951	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:47678951G>A	ENST00000397708.1	-	17	3890	c.3636C>T	c.(3634-3636)gtC>gtT	p.V1212V	MCM3AP_ENST00000291688.1_Silent_p.V1212V|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000590829.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1212					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AGTGGGCACAGACATCCTCAC	0.537000													31	84					0	0	0.045705	0	0
ABHD17B	51104	broad.mit.edu	37	9	74477498	74477498	+	Nonstop_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:74477498C>A	ENST00000377041.2	-	5	1181	c.881G>T	c.(880-882)tGa>tTa	p.*294L		NM_016014.2	NP_057098.2			abhydrolase domain containing 17B																		ttgagaaaatcacttcccttc	0.338000													8	25					0.0692343	0.0697324	0.069234	1	0
FAM86EP	348926	broad.mit.edu	37	4	3949895	3949895	+	RNA	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:3949895C>A	ENST00000281228.8	-	0	396				FAM86EP_ENST00000313946.8_RNA																							GCCTGTGGTGCCGTGGGAGAT	0.622000													23	44					2.44723e-14	2.86945e-14	0.024334	1	0
UBAP1	51271	broad.mit.edu	37	9	34241369	34241369	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:34241369C>G	ENST00000536252.1	+	5	744	c.346C>G	c.(346-348)Cct>Gct	p.P116A	UBAP1_ENST00000545103.1_Missense_Mutation_p.P180A|UBAP1_ENST00000379186.4_Missense_Mutation_p.P116A|UBAP1_ENST00000540348.1_Missense_Mutation_p.P116A|UBAP1_ENST00000543944.1_Missense_Mutation_p.P152A|UBAP1_ENST00000359544.2_Missense_Mutation_p.P116A|UBAP1_ENST00000297661.4_Missense_Mutation_p.P116A	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	116						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			AATGCCACCTCCTATTAACCC	0.512000													33	88					0	0	0.080422	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958095	57958095	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:57958095A>G	ENST00000311591.3	+	1	190	c.133A>G	c.(133-135)Atg>Gtg	p.M45V		NM_001005283.2	NP_001005283.1	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(24)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41		Breast(21;0.0589)				GAACACAGGCATGATCCTCCT	0.498000													11	19					0	0	0.010729	0	0
E2F7	144455	broad.mit.edu	37	12	77426850	77426850	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:77426850C>T	ENST00000322886.7	-	9	1597	c.1362G>A	c.(1360-1362)caG>caA	p.Q454Q	E2F7_ENST00000416496.2_Silent_p.Q454Q	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	454					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						CTTCTATTTTCTGTCTATAGA	0.373000													19	29					0	0	0.021523	0	0
CSMD2	114784	broad.mit.edu	37	1	34190196	34190196	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:34190196C>G	ENST00000373381.4	-	18	2981	c.2805G>C	c.(2803-2805)tcG>tcC	p.S935S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	895	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATGTGTAGCCCGAGTCACAGC	0.587000													24	64					0	0	0.024334	0	0
SPTB	6710	broad.mit.edu	37	14	65253478	65253478	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:65253478C>T	ENST00000389722.3	-	15	3258	c.3205G>A	c.(3205-3207)Gat>Aat	p.D1069N	SPTB_ENST00000389720.3_Missense_Mutation_p.D1069N|SPTB_ENST00000389721.5_Missense_Mutation_p.D1069N|SPTB_ENST00000542895.1_Missense_Mutation_p.D1069N|SPTB_ENST00000556626.1_Missense_Mutation_p.D1069N	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1069					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCATCCAGATCCTGCAGGAAG	0.622000													25	44					0	0	0.037714	0	0
FAM109B	150368	broad.mit.edu	37	22	42473379	42473379	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:42473379G>C	ENST00000321753.3	+	3	269	c.82G>C	c.(82-84)Ggg>Cgg	p.G28R		NM_001002034.2	NP_001002034.2	Q6ICB4	SESQ2_HUMAN	family with sequence similarity 109, member B	28	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity			endometrium(2)|large_intestine(2)|liver(2)|lung(1)|prostate(1)	8						GCGCACCTGGGGGGGCCCAGG	0.637000													72	47					0	0	0.048971	0	0
CYP7B1	9420	broad.mit.edu	37	8	65509386	65509386	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:65509386C>T	ENST00000310193.3	-	6	1507	c.1334G>A	c.(1333-1335)gGa>gAa	p.G445E	CYP7B1_ENST00000523954.1_Intron	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	445					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TTTGCTGGTTCCAGTTCCAAA	0.323000													15	33					0	0	0.033300	0	0
APOL5	80831	broad.mit.edu	37	22	36122339	36122339	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:36122339C>A	ENST00000249044.2	+	3	224	c.224C>A	c.(223-225)tCc>tAc	p.S75Y		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	75					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						GGTATGCTGTCCTACTTTCTG	0.418000													33	22					4.34086e-07	4.6892e-07	0.080422	1	0
ZNF91	7644	broad.mit.edu	37	19	23542380	23542380	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:23542380T>A	ENST00000300619.7	-	4	3606	c.3401A>T	c.(3400-3402)tAc>tTc	p.Y1134F	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.Y1102F	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1134						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTCACATTTGTAGGGTTTCTC	0.393000													16	31					0	0	0.024245	0	0
STPG2	285555	broad.mit.edu	37	4	98762043	98762043	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:98762043T>A	ENST00000295268.3	-	9	1174	c.1085A>T	c.(1084-1086)tAt>tTt	p.Y362F	STPG2_ENST00000506482.1_Intron	NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		GGACATCTCATATGATTTGTG	0.358000													26	32					0	0	0.018920	0	0
GLCCI1	113263	broad.mit.edu	37	7	8095167	8095167	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:8095167C>G	ENST00000223145.5	+	4	1358	c.801C>G	c.(799-801)atC>atG	p.I267M	GLCCI1_ENST00000474269.1_3'UTR	NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	267										endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		ATATAACAATCAGTCACACTC	0.398000													76	43					0	0	0.048971	0	0
GABRB1	2560	broad.mit.edu	37	4	47427732	47427732	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:47427732C>A	ENST00000295454.3	+	9	1414	c.1122C>A	c.(1120-1122)atC>atA	p.I374I	GABRB1_ENST00000538619.1_Silent_p.I304I	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	374					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCCTGGAAATCCGGAATGAGA	0.562000													27	55					8.73648e-17	1.0544e-16	0.069456	1	0
CCDC108	255101	broad.mit.edu	37	2	219870856	219870856	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:219870856G>A	ENST00000341552.5	-	31	4892	c.4809C>T	c.(4807-4809)tgC>tgT	p.C1603C	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Silent_p.C1603C|CCDC108_ENST00000441968.1_Silent_p.C1603C	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1603						integral to membrane	structural molecule activity	p.C1603W(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGCTGGGGGCAGGGCCAGG	0.617000													27	88					0	0	0.050027	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					8	71					0	0	0.049695	0	0
TTI1	9675	broad.mit.edu	37	20	36625251	36625251	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:36625251G>A	ENST00000373448.2	-	7	3136	c.2898C>T	c.(2896-2898)atC>atT	p.I966I	TTI1_ENST00000373447.3_Silent_p.I966I|TTI1_ENST00000449821.1_Silent_p.I966I	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	966							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CCCTGGCACTGATGGGGGCCT	0.597000													53	141					0	0	0.048971	0	0
PCDH1	5097	broad.mit.edu	37	5	141236903	141236903	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:141236903C>A	ENST00000287008.3	-	4	3380	c.3233G>T	c.(3232-3234)cGa>cTa	p.R1078L	PCDH1_ENST00000503492.1_Missense_Mutation_p.R346L	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	0					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GGGACCGAGTCGAGGCCCTGA	0.627000													21	34					6.21321e-17	7.52465e-17	0.076483	1	0
DOCK4	9732	broad.mit.edu	37	7	111379217	111379217	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:111379217G>A	ENST00000428084.1	-	49	5477	c.5205C>T	c.(5203-5205)atC>atT	p.I1735I	DOCK4_ENST00000494651.2_Silent_p.I609I|DOCK4_ENST00000437633.1_Silent_p.I1726I			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1726	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GTGTTGGATAGATGGCACTGC	0.463000													26	81					0	0	0.050027	0	0
SLC9A4	389015	broad.mit.edu	37	2	103149081	103149081	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:103149081G>T	ENST00000295269.4	+	12	2788	c.2331G>T	c.(2329-2331)tgG>tgT	p.W777C		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	777					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GGTCGAGGTGGACAGCTGACC	0.507000													5	20					5.9392e-07	6.39606e-07	0.021553	1	0
NALCN	259232	broad.mit.edu	37	13	101714406	101714406	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:101714406C>G	ENST00000251127.6	-	41	4750	c.4669G>C	c.(4669-4671)Gag>Cag	p.E1557Q		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1557						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCAGCTGCTCCCTCGCCAGG	0.572000													28	57					0	0	0.030593	0	0
XAGE3	170626	broad.mit.edu	37	X	52896082	52896082	+	Splice_Site	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:52896082A>T	ENST00000346279.3	-	2	152		c.e2+1		XAGE3_ENST00000375491.3_Splice_Site	NM_133179.2	NP_573440.1	Q8WTP9	GAGD4_HUMAN	X antigen family, member 3											kidney(1)|large_intestine(1)|lung(2)	4						TAAGGCACTCACCAGCATAGG	0.398000													27	16					0	0	0.030593	0	0
SSPO	23145	broad.mit.edu	37	7	149495214	149495214	+	RNA	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:149495214G>T	ENST00000378016.2	+	0	6961							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCCCGACAGGTGTGTGCACA	0.652000													69	94					1.78623e-52	2.41849e-52	0.048971	1	0
C1orf173	127254	broad.mit.edu	37	1	75037590	75037590	+	Silent	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:75037590T>A	ENST00000326665.5	-	14	4022	c.3804A>T	c.(3802-3804)ctA>ctT	p.L1268L	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1268	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCTGGGTCCTTAGCACGACAT	0.572000													49	98					0	0	0.048971	0	0
HAO1	54363	broad.mit.edu	37	20	7866418	7866418	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:7866418C>A	ENST00000378789.3	-	6	958	c.907G>T	c.(907-909)Gct>Tct	p.A303S		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	303	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGAGCCAGAGCTTTCAGAACA	0.498000													48	102					7.50695e-29	9.71325e-29	0.048971	1	0
USP37	57695	broad.mit.edu	37	2	219418306	219418306	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:219418306C>G	ENST00000258399.3	-	5	710	c.298G>C	c.(298-300)Gat>Cat	p.D100H	USP37_ENST00000454775.1_Missense_Mutation_p.D100H|USP37_ENST00000418019.1_Missense_Mutation_p.D100H|USP37_ENST00000415516.1_Missense_Mutation_p.D28H|USP37_ENST00000338465.5_Missense_Mutation_p.D100H	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	100					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TGGACTGCATCTAGAAACAAC	0.413000													16	37					0	0	0.049695	0	0
PLSCR5	389158	broad.mit.edu	37	3	146307453	146307453	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:146307453G>C	ENST00000443512.1	-	6	1767	c.764C>G	c.(763-765)gCc>gGc	p.A255G	PLSCR5_ENST00000492200.1_Missense_Mutation_p.A255G|PLSCR5_ENST00000482567.1_Missense_Mutation_p.A243G|PLSCR5-AS1_ENST00000473817.1_RNA	NM_001085420.1	NP_001078889.1	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	255										endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						GAGAAAACAGGCACCGATCAT	0.383000													19	69					0	0	0.062417	0	0
ZNF711	7552	broad.mit.edu	37	X	84526329	84526329	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:84526329A>G	ENST00000360700.4	+	10	2805	c.1919A>G	c.(1918-1920)cAt>cGt	p.H640R	ZNF711_ENST00000276123.3_Missense_Mutation_p.H594R|ZNF711_ENST00000373165.3_Missense_Mutation_p.H594R|ZNF711_ENST00000395402.1_Missense_Mutation_p.H602R|ZNF711_ENST00000542798.1_Missense_Mutation_p.H436R			Q9Y462	ZN711_HUMAN	zinc finger protein 711	594					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						CAGTGTCCTCATTGTGACCAT	0.433000													6	2					0	0	0.029380	0	0
C3AR1	719	broad.mit.edu	37	12	8211415	8211415	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:8211415G>C	ENST00000307637.4	-	2	1570	c.1367C>G	c.(1366-1368)gCa>gGa	p.A456G		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	456					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		ACTGAAGGCTGCCTCCAGAAT	0.458000													28	44					0	0	0.037714	0	0
OR4A16	81327	broad.mit.edu	37	11	55111088	55111088	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55111088G>T	ENST00000314721.2	+	1	462	c.412G>T	c.(412-414)Gtt>Ttt	p.V138F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GAATCGACTGGTTTGCATCCT	0.473000													29	60					3.99451e-17	4.87135e-17	0.041601	1	0
XG	7499	broad.mit.edu	37	X	2712605	2712605	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:2712605G>A	ENST00000426774.1	+	6	509	c.286G>A	c.(286-288)Gga>Aga	p.G96R	XG_ENST00000381174.5_Missense_Mutation_p.G95R|XG_ENST00000419513.2_Missense_Mutation_p.G95R	NM_001141920.1|NM_175569.2	NP_001135392.1|NP_780778.1	P55808	XG_HUMAN	Xg blood group	95						integral to membrane|plasma membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCGTGATGACGGACGCTACCC	0.612000													7	8					0	0	0.058154	0	0
TNXB	7148	broad.mit.edu	37	6	32036752	32036752	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:32036752C>A	ENST00000375244.3	-	16	5950	c.5749G>T	c.(5749-5751)Gat>Tat	p.D1917Y	TNXB_ENST00000375247.2_Missense_Mutation_p.D1917Y			P22105	TENX_HUMAN	tenascin XB	1999	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCGTCTCTATCTGTGTACTGG	0.552000													48	143					1.35996e-42	1.8237e-42	0.048971	1	0
DSG4	147409	broad.mit.edu	37	18	28993456	28993456	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:28993456G>A	ENST00000359747.4	+	15	3107	c.3078G>A	c.(3076-3078)atG>atA	p.M1026I	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.M1007I|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	1007					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCAAATGATGAGTCCAGACC	0.473000													9	82					0	0	0.010729	0	0
SIRPG	55423	broad.mit.edu	37	20	1616208	1616208	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:1616208C>A	ENST00000381580.1	-	4	866	c.687G>T	c.(685-687)agG>agT	p.R229S	SIRPG_ENST00000216927.4_Intron|SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000381583.2_Intron|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000303415.3_Missense_Mutation_p.R262S			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	262	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						GGTTCCCCACCCTCATGGGCT	0.552000													25	42					2.36697e-06	2.52573e-06	0.034045	1	0
ANK3	288	broad.mit.edu	37	10	61932732	61932732	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:61932732C>T	ENST00000280772.1	-	20	2499	c.2308G>A	c.(2308-2310)Gca>Aca	p.A770T	ANK3_ENST00000503366.1_Missense_Mutation_p.A753T|ANK3_ENST00000373827.2_Missense_Mutation_p.A764T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	770					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGCTGTGCTGCTTGATGTAAT	0.428000													16	80					0	0	0.049695	0	0
ZNF675	171392	broad.mit.edu	37	19	23836495	23836495	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:23836495G>A	ENST00000359788.4	-	4	1408	c.1240C>T	c.(1240-1242)Cat>Tat	p.H414Y	ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000601935.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	414					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ATTCTCTTATGTGTAGTAAGG	0.373000													21	45					0	0	0.076483	0	0
AASS	10157	broad.mit.edu	37	7	121726159	121726159	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:121726159C>G	ENST00000393376.1	-	18	2186	c.2091G>C	c.(2089-2091)ttG>ttC	p.L697F	AASS_ENST00000473553.1_5'UTR|AASS_ENST00000417368.2_Missense_Mutation_p.L697F			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	697	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	GATAGCCTTCCAAATTTAATC	0.428000													20	53					0	0	0.049695	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86346828	86346828	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:86346828C>T	ENST00000355238.6	-	6	729	c.523G>A	c.(523-525)Gag>Aag	p.E175K	SYNCRIP_ENST00000369622.3_Missense_Mutation_p.E175K	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	175	RRM 1.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		AGTTCATCCTCAAATAGATCT	0.363000													9	29					0	0	0.058154	0	0
ZNF93	81931	broad.mit.edu	37	19	20026089	20026089	+	Splice_Site	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:20026089G>T	ENST00000343769.5	+	2	32	c.3_splice	c.e2-1	p.G2_splice	ZNF93_ENST00000592160.1_Splice_Site_p.G2_splice|AC007204.2_ENST00000592245.1_lincRNA|ZNF93_ENST00000591366.1_Splice_Site_p.G2_splice	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	2						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TGTTTTTCAGGGACCATTGCA	0.413000													39	138					3.86236e-30	5.03473e-30	0.048971	1	0
KLRD1	3824	broad.mit.edu	37	12	10462274	10462274	+	Silent	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:10462274A>T	ENST00000381908.3	+	3	410	c.150A>T	c.(148-150)atA>atT	p.I50I	KLRD1_ENST00000350274.5_Silent_p.I19I|KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000543777.1_Intron|KLRD1_ENST00000381907.4_Silent_p.I50I|KLRD1_ENST00000543420.1_Silent_p.I50I|KLRD1_ENST00000336164.4_Silent_p.I50I			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	50					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						GACCCAACATAGAACTCCAGA	0.333000													18	12					0	0	0.027356	0	0
HIPK4	147746	broad.mit.edu	37	19	40885612	40885612	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:40885612C>A	ENST00000291823.2	-	4	2017	c.1733G>T	c.(1732-1734)tGc>tTc	p.C578F		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	578						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CTCCAGGGTGCAGTCTGGCTC	0.677000													8	33					0.0381472	0.0386441	0.038147	1	0
CNST	163882	broad.mit.edu	37	1	246784876	246784876	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:246784876A>G	ENST00000366513.4	+	3	794	c.525A>G	c.(523-525)tcA>tcG	p.S175S	CNST_ENST00000366512.3_Silent_p.S175S|CNST_ENST00000483271.1_3'UTR	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	175					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						CTCTGTTTTCACTTATACGAG	0.453000													53	169					0	0	0.048971	0	0
DHX40	79665	broad.mit.edu	37	17	57684443	57684443	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:57684443C>A	ENST00000451169.2	+	21	2465	c.2106C>A	c.(2104-2106)gaC>gaA	p.D702E	DHX40_ENST00000425628.3_Missense_Mutation_p.D673E|DHX40_ENST00000251241.4_Missense_Mutation_p.D750E			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	750							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GAAATGATGACAAATCCATAT	0.403000													19	54					1.01871e-10	1.15763e-10	0.049695	1	0
IL18RAP	8807	broad.mit.edu	37	2	103040355	103040355	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:103040355A>T	ENST00000264260.2	+	4	744	c.155A>T	c.(154-156)cAg>cTg	p.Q52L	IL18RAP_ENST00000409369.1_Intron	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	52					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CCAGAGCCACAGAAATCACAT	0.403000													15	26					0	0	0.028581	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111769520	111769520	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:111769520T>A	ENST00000452346.2	+	9	1096	c.1093T>A	c.(1093-1095)Tgt>Agt	p.C365S	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.C239S			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	365	CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TTTTCCAGAGTGTGAAAACAC	0.398000													81	258					0	0	0.048971	0	0
NAB2	4665	broad.mit.edu	37	12	57485106	57485106	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:57485106C>T	ENST00000300131.3	+	2	660	c.282C>T	c.(280-282)ctC>ctT	p.L94L	NAB2_ENST00000357680.4_Silent_p.L94L|NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000342556.6_Silent_p.L94L	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	94	NCD1.				cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CCAAGCCCCTCCATGTCCGGC	0.622000													56	95					0	0	0.048971	0	0
TTC12	54970	broad.mit.edu	37	11	113194080	113194080	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:113194080G>C	ENST00000393020.1	+	3	534	c.129G>C	c.(127-129)aaG>aaC	p.K43N	TTC12_ENST00000483239.2_Missense_Mutation_p.K43N|TTC12_ENST00000529221.1_Missense_Mutation_p.K43N|TTC12_ENST00000314756.3_Missense_Mutation_p.K43N			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	43							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		AGACAGAAAAGAGACTACTGC	0.433000													37	68					0	0	0.080422	0	0
RPH3A	22895	broad.mit.edu	37	12	113316981	113316981	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:113316981A>G	ENST00000389385.4	+	14	1726	c.1229A>G	c.(1228-1230)cAg>cGg	p.Q410R	RPH3A_ENST00000543106.2_Missense_Mutation_p.Q410R|RPH3A_ENST00000415485.3_Missense_Mutation_p.Q410R|RPH3A_ENST00000447659.2_Missense_Mutation_p.Q361R|RPH3A_ENST00000551052.1_Missense_Mutation_p.Q406R|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000420983.2_Missense_Mutation_p.Q410R|RPH3A_ENST00000548866.1_Missense_Mutation_p.Q361R	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	410	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		AGCTCCCTGCAGTGCACCATC	0.557000													56	55					0	0	0.048971	0	0
SNTG2	54221	broad.mit.edu	37	2	1133490	1133490	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:1133490G>C	ENST00000308624.5	+	6	535	c.406G>C	c.(406-408)Gaa>Caa	p.E136Q	SNTG2_ENST00000407292.1_Intron	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	136	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AACTCATGAAGAAGTGGTAAG	0.269000													26	47					0	0	0.059317	0	0
PTX4	390667	broad.mit.edu	37	16	1536191	1536191	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:1536191G>A	ENST00000447419.2	-	3	1211	c.1186C>T	c.(1186-1188)Ccc>Tcc	p.P396S	PTX4_ENST00000293922.1_Missense_Mutation_p.P391S|PTX4_ENST00000440447.2_3'UTR			Q96A99	PTX4_HUMAN	pentraxin 4, long	396	Pentaxin.					extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						CCTCCGGGGGGGATCTCATAG	0.657000													14	57					0	0	0.028581	0	0
SLAMF8	56833	broad.mit.edu	37	1	159803054	159803054	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:159803054C>A	ENST00000289707.5	+	4	825	c.676C>A	c.(676-678)Cca>Aca	p.P226T	SLAMF8_ENST00000471286.1_3'UTR|SLAMF8_ENST00000368104.4_Missense_Mutation_p.P117T	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8	226						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					ATGTTCAGCACCAGGGAAGGC	0.572000													175	206					4.17301e-93	5.68309e-93	0.048971	1	0
GKAP1	80318	broad.mit.edu	37	9	86368180	86368180	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:86368180T>G	ENST00000376371.2	-	9	1233	c.833A>C	c.(832-834)cAa>cCa	p.Q278P	GKAP1_ENST00000376365.3_Missense_Mutation_p.Q227P	NM_025211.3	NP_079487.2	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1	278					signal transduction	Golgi apparatus				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	14						AACCTCCCATTGAGTGATTAC	0.299000													23	92					0	0	0.018920	0	0
EGFR	1956	broad.mit.edu	37	7	55269468	55269468	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:55269468G>T	ENST00000275493.2	+	26	3332	c.3155G>T	c.(3154-3156)aGa>aTa	p.R1052I	EGFR_ENST00000455089.1_Missense_Mutation_p.R1007I|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Missense_Mutation_p.R999I	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1052	Ser-rich.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCATTGATAGAAATGGGGTA	0.398000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			48	156					1.13205e-32	1.49515e-32	0.048971	1	0
TTN	7273	broad.mit.edu	37	2	179642232	179642232	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:179642232G>T	ENST00000589042.1	-	26	4784	c.4560C>A	c.(4558-4560)gcC>gcA	p.A1520A	TTN_ENST00000342992.6_Silent_p.A1520A|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000360870.5_Silent_p.A1520A|TTN_ENST00000460472.2_Silent_p.A1474A|TTN_ENST00000359218.5_Silent_p.A1474A|TTN_ENST00000591111.1_Silent_p.A1520A|TTN_ENST00000342175.6_Silent_p.A1474A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1520	Ig-like 6.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGGGTGTGGCAGGGACAA	0.388000													14	44					3.27435e-08	3.60952e-08	0.020292	1	0
CLSTN1	22883	broad.mit.edu	37	1	9790694	9790694	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:9790694C>T	ENST00000377298.4	-	19	3610	c.2818G>A	c.(2818-2820)Gaa>Aaa	p.E940K	CLSTN1_ENST00000361311.4_Missense_Mutation_p.E930K|CLSTN1_ENST00000377288.3_Missense_Mutation_p.E921K|CLSTN1_ENST00000477264.1_5'UTR	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	940	Glu-rich (highly acidic).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TCCTCTTCTTCGCCGTCCTCG	0.622000													16	40					0	0	0.049695	0	0
SATB1	6304	broad.mit.edu	37	3	18419677	18419677	+	Silent	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:18419677T>G	ENST00000338745.6	-	9	3294	c.1560A>C	c.(1558-1560)gcA>gcC	p.A520A	SATB1_ENST00000417717.2_Silent_p.A520A|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Silent_p.A520A	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	520					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TTTTGGTTGCTGCAACCTTTG	0.388000													34	46					0	0	0.048971	0	0
ATE1	11101	broad.mit.edu	37	10	123662043	123662043	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:123662043C>A	ENST00000369043.3	-	6	762	c.676G>T	c.(676-678)Gct>Tct	p.A226S	ATE1_ENST00000540606.1_Missense_Mutation_p.A219S|ATE1_ENST00000369040.3_Missense_Mutation_p.A130S|ATE1_ENST00000535655.1_Intron|ATE1_ENST00000224652.6_Missense_Mutation_p.A226S|ATE1_ENST00000481784.1_5'UTR|ATE1_ENST00000543447.1_Missense_Mutation_p.A111S	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	226					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				AGTTCTCCAGCTGGGTTCTGC	0.433000													16	37					0.000308642	0.000321024	0.024245	1	0
PIK3CA	5290	broad.mit.edu	37	3	178928079	178928079	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:178928079G>C	ENST00000263967.3	+	8	1514	c.1357G>C	c.(1357-1359)Gaa>Caa	p.E453Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(11)|p.E453Q(5)|p.H450fs*9(1)|p.G451_L456>V(1)|p.P449_L455del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATGGATTAGAAGATTTGCT	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			75	69					0	0	0.048971	0	0
SYNE2	23224	broad.mit.edu	37	14	64447432	64447432	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:64447432G>C	ENST00000358025.3	+	15	1860	c.1630G>C	c.(1630-1632)Gaa>Caa	p.E544Q	SYNE2_ENST00000554584.1_Missense_Mutation_p.E544Q|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.E544Q	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	544					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAAATGTGGAGAAATTTATAA	0.294000													5	16					0	0	0.021553	0	0
HIST1H2AH	85235	broad.mit.edu	37	6	27114968	27114968	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:27114968C>G	ENST00000377459.1	+	1	108	c.61C>G	c.(61-63)Cgg>Ggg	p.R21G		NM_080596.1	NP_542163.1	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	21					nucleosome assembly	nucleosome|nucleus	DNA binding	p.R21R(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|prostate(1)|skin(1)	12						CCGCTCTTCTCGGGCTGGGCT	0.622000													28	79					0	0	0.045705	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512795	68512795	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:68512795G>A	ENST00000370981.1	-	4	822	c.186C>T	c.(184-186)ttC>ttT	p.F62F	DIRAS3_ENST00000395201.1_Silent_p.F62F|GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	62					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						ACTCATGACGGAAGTTGCCGC	0.582000													44	103					0	0	0.048971	0	0
C20orf96	140680	broad.mit.edu	37	20	257404	257404	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:257404C>A	ENST00000400269.3	-	7	827	c.768G>T	c.(766-768)ctG>ctT	p.L256L	C20orf96_ENST00000382369.5_Intron|C20orf96_ENST00000360321.2_Intron			Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	0										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			TGCTTCCCTACAGGGACCACC	0.567000													11	6					0.0167234	0.0169904	0.016723	1	0
VCAM1	7412	broad.mit.edu	37	1	101186295	101186295	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:101186295G>T	ENST00000294728.2	+	2	429	c.328G>T	c.(328-330)Gtg>Ttg	p.V110L	VCAM1_ENST00000370119.4_Intron|VCAM1_ENST00000370115.1_Missense_Mutation_p.V110L|VCAM1_ENST00000347652.2_Missense_Mutation_p.V110L	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	110	Ig-like C2-type 2.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGGAATCCAGGTGGAGATCTA	0.318000													16	38					4.54149e-19	5.66674e-19	0.069288	1	0
OR14C36	127066	broad.mit.edu	37	1	248512673	248512673	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:248512673C>A	ENST00000317861.1	+	1	597	c.597C>A	c.(595-597)gtC>gtA	p.V199V		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TGATTGTTGTCTCTGCTCTGG	0.483000													26	86					3.73988e-18	4.60901e-18	0.030593	1	0
USP13	8975	broad.mit.edu	37	3	179478938	179478938	+	Missense_Mutation	SNP	G	G	C	rs61733591		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:179478938G>C	ENST00000263966.3	+	17	2458	c.1987G>C	c.(1987-1989)Gag>Cag	p.E663Q	USP13_ENST00000496897.1_Missense_Mutation_p.E598Q	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	663	UBA 1.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GCAGCTGGCCGAGATGGGTTT	0.493000													40	135					0	0	0.048971	0	0
DIS3	22894	broad.mit.edu	37	13	73345239	73345239	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:73345239G>A	ENST00000377767.4	-	12	1750	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S	DIS3_ENST00000545453.1_Silent_p.S388S|DIS3_ENST00000377780.4_Silent_p.S520S	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	550					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CACATTTTAAGGAACACAAGT	0.343000										Multiple Myeloma(4;0.011)			17	26					0	0	0.062417	0	0
PRTG	283659	broad.mit.edu	37	15	55964742	55964742	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:55964742T>A	ENST00000389286.4	-	11	1989	c.1942A>T	c.(1942-1944)Att>Ttt	p.I648F		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	648	Fibronectin type-III 3.				multicellular organismal development	integral to membrane		p.I648F(1)		breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TAGCCCTGAATAGCAGCTGTG	0.488000													17	41					0	0	0.049695	0	0
COL6A6	131873	broad.mit.edu	37	3	130284269	130284269	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:130284269C>A	ENST00000358511.6	+	3	1124	c.1093C>A	c.(1093-1095)Ctg>Atg	p.L365M	COL6A6_ENST00000453409.2_Missense_Mutation_p.L365M	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	365	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen		p.L365M(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CATCTTCACCCTGGGCATAGA	0.572000													93	101					5.77035e-48	7.79776e-48	0.048971	1	0
RYR2	6262	broad.mit.edu	37	1	237780642	237780642	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:237780642C>A	ENST00000366574.2	+	38	6089	c.5772C>A	c.(5770-5772)gcC>gcA	p.A1924A	RYR2_ENST00000542537.1_Silent_p.A1908A|RYR2_ENST00000360064.6_Silent_p.A1922A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1924	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGATAGAAGCCATTGTAGCCT	0.433000													8	30					3.09899e-07	3.35284e-07	0.047766	1	0
IQCB1	9657	broad.mit.edu	37	3	121547718	121547718	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:121547718C>G	ENST00000310864.6	-	3	304	c.90G>C	c.(88-90)ttG>ttC	p.L30F	IQCB1_ENST00000349820.6_Missense_Mutation_p.L30F	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	30					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding			NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		CTTTTAACTTCAACAGTATAA	0.333000													5	69					0	0	0.014758	0	0
TXLNB	167838	broad.mit.edu	37	6	139609632	139609632	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:139609632C>A	ENST00000358430.3	-	2	637	c.405G>T	c.(403-405)aaG>aaT	p.K135N		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	135						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TTAGGATTTTCTTTTCCAATT	0.413000													28	77					4.74835e-14	5.53053e-14	0.045705	1	0
JAG1	182	broad.mit.edu	37	20	10639247	10639247	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:10639247T>C	ENST00000254958.5	-	4	1078	c.563A>G	c.(562-564)gAt>gGt	p.D188G	JAG1_ENST00000423891.2_Missense_Mutation_p.D29G	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	188	DSL.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						GTAGTAGTCATCACAGGTCAC	0.532000									Alagille Syndrome				33	76					0	0	0.069456	0	0
CCT8	10694	broad.mit.edu	37	21	30435737	30435737	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:30435737T>A	ENST00000286788.4	-	8	1083	c.877A>T	c.(877-879)Aca>Tca	p.T293S	CCT8_ENST00000470450.1_5'UTR|CCT8_ENST00000542732.1_Missense_Mutation_p.T274S|CCT8_ENST00000540844.1_Missense_Mutation_p.T220S	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	293					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						TTGCCACCTGTTACTACGACA	0.353000													30	53					0	0	0.074837	0	0
TTYH2	94015	broad.mit.edu	37	17	72249298	72249298	+	Silent	SNP	G	G	A	rs138705961		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:72249298G>A	ENST00000441391.2	+	6	1587	c.375G>A	c.(373-375)ccG>ccA	p.P125P	TTYH2_ENST00000529107.1_Silent_p.P425P|TTYH2_ENST00000269346.4_Silent_p.P446P	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	446						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						ACAGTCCCCCGAGGGGACAGC	0.587000													11	171					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	8994195	8994195	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:8994195G>A	ENST00000397910.4	-	65	41693	c.41490C>T	c.(41488-41490)ttC>ttT	p.F13830F	MUC16_ENST00000380951.5_Silent_p.F471F	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13833	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTGTTCTTGAACAAGGGCC	0.537000													33	64					0	0	0.036044	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559546	140559546	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140559546T>A	ENST00000239444.2	+	1	2176	c.1931T>A	c.(1930-1932)cTg>cAg	p.L644Q		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		644	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGTGGTGCTGGTCAAGGAC	0.697000													34	31					0	0	0.069456	0	0
B4GALT5	9334	broad.mit.edu	37	20	48330195	48330195	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:48330195C>A	ENST00000371711.4	-	1	220	c.33G>T	c.(31-33)ccG>ccT	p.P11P		NM_004776.3	NP_004767.1	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	11					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			GCGAGCGGCGCGGCAGCCGCA	0.721000													4	8					0.014758	0.0150154	0.014758	1	0
CD5L	922	broad.mit.edu	37	1	157803231	157803231	+	Missense_Mutation	SNP	C	C	G	rs146902396		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:157803231C>G	ENST00000368174.4	-	5	886	c.790G>C	c.(790-792)Gta>Cta	p.V264L		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	264	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GAGCCCCATACGCCCTTGTGC	0.567000													40	180					0	0	0.048971	0	0
PTK7	5754	broad.mit.edu	37	6	43111325	43111325	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:43111325G>A	ENST00000230419.4	+	14	2439	c.2218G>A	c.(2218-2220)Gag>Aag	p.E740K	PTK7_ENST00000352931.2_Missense_Mutation_p.E684K|PTK7_ENST00000349241.2_Missense_Mutation_p.E610K|PTK7_ENST00000345201.2_Missense_Mutation_p.E700K|PTK7_ENST00000481273.1_Missense_Mutation_p.E748K	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	740					actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GAAGCAGCCCGAGGGCGAGGA	0.667000											OREG0017450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	17					0	0	0.058154	0	0
SWT1	54823	broad.mit.edu	37	1	185143850	185143850	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:185143850A>T	ENST00000367500.4	+	5	736	c.571A>T	c.(571-573)Aac>Tac	p.N191Y	SWT1_ENST00000367501.3_Missense_Mutation_p.N191Y	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	191										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						GAAAGGAAGAAACAGTAAATT	0.348000													20	18					0	0	0.062417	0	0
KIAA0556	23247	broad.mit.edu	37	16	27765513	27765513	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:27765513C>T	ENST00000261588.4	+	18	3591	c.3572C>T	c.(3571-3573)cCa>cTa	p.P1191L		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1191										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CTAGAGCTCCCATCCAGTTCC	0.572000													76	78					0	0	0.048971	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351075	89351075	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:89351075C>T	ENST00000301030.4	-	9	2335	c.1875G>A	c.(1873-1875)gaG>gaA	p.E625E	ANKRD11_ENST00000378330.2_Silent_p.E625E	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	625	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAACTTTCCCCTCCTTGTCCA	0.498000													27	71					0	0	0.027356	0	0
PLIN5	440503	broad.mit.edu	37	19	4529859	4529859	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:4529859G>A	ENST00000381848.3	-	4	356	c.276C>T	c.(274-276)ctC>ctT	p.L92L	CTB-50L17.14_ENST00000586020.1_3'UTR	NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	92						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CCCTGCAGGCGAGGCTGTTCA	0.607000													27	57					0	0	0.037714	0	0
TCL1A	8115	broad.mit.edu	37	14	96180344	96180344	+	Silent	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:96180344G>T	ENST00000402399.1	-	1	189	c.60C>A	c.(58-60)gcC>gcA	p.A20A	TCL1A_ENST00000555202.1_Silent_p.A20A|TCL1A_ENST00000554012.1_Silent_p.A20A|RP11-164H13.1_ENST00000547644.2_RNA|RP11-164H13.1_ENST00000553445.1_RNA|TCL1A_ENST00000556450.1_Silent_p.A20A	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	20					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		ACTTCTCCCAGGCCCACAGGC	0.652000			T	TRA@	T-CLL								47	89					6.3008e-33	8.33755e-33	0.048971	1	0
TAMM41	132001	broad.mit.edu	37	3	11851124	11851124	+	Missense_Mutation	SNP	C	C	G	rs140106641	byFrequency	TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:11851124C>G	ENST00000444133.2	-	6	883	c.741G>C	c.(739-741)caG>caC	p.Q247H	TAMM41_ENST00000455809.1_Missense_Mutation_p.Q247H|TAMM41_ENST00000273037.5_Missense_Mutation_p.Q247H			Q96BW9	MMP37_HUMAN	TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)	247					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane											ATGTCATCAGCTGAGTGAACT	0.398000													20	27					0	0	0.024334	0	0
NELL2	4753	broad.mit.edu	37	12	45209863	45209863	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:45209863G>T	ENST00000429094.2	-	3	745	c.241C>A	c.(241-243)Ctg>Atg	p.L81M	NELL2_ENST00000551601.1_Missense_Mutation_p.L80M|NELL2_ENST00000548826.1_Missense_Mutation_p.L81M|NELL2_ENST00000547172.1_5'UTR|NELL2_ENST00000395487.2_Missense_Mutation_p.L80M|NELL2_ENST00000333837.4_Missense_Mutation_p.L104M|NELL2_ENST00000452445.2_Missense_Mutation_p.L81M|NELL2_ENST00000437801.2_Missense_Mutation_p.L131M|NELL2_ENST00000549027.1_Missense_Mutation_p.L80M	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	81	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTATTTCTCAGCTTCTGAAAA	0.333000													7	101					0.0477658	0.0482482	0.047766	1	0
MYL5	4636	broad.mit.edu	37	4	673776	673776	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:673776G>T	ENST00000506838.1	+	5	2662	c.138G>T	c.(136-138)atG>atT	p.M46I	MYL5_ENST00000511290.1_Missense_Mutation_p.M46I|MYL5_ENST00000400159.2_Missense_Mutation_p.M87I|MYL5_ENST00000505477.1_Missense_Mutation_p.M46I			Q02045	MYL5_HUMAN	myosin, light chain 5, regulatory	87	EF-hand 1.				regulation of muscle contraction	muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(1)|kidney(1)|lung(1)	3						ACTTCACCATGTTTCTGAACC	0.567000													25	52					1.06801e-11	1.22358e-11	0.041601	1	0
BPIFB3	359710	broad.mit.edu	37	20	31647285	31647285	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:31647285C>G	ENST00000375494.3	+	3	383	c.383C>G	c.(382-384)tCt>tGt	p.S128C		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	128	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										ATGCATTGCTCTGGGTGAGTG	0.602000													7	22					0	0	0.029380	0	0
HOXA3	3200	broad.mit.edu	37	7	27149900	27149900	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:27149900C>A	ENST00000396352.4	-	2	559	c.360G>T	c.(358-360)ccG>ccT	p.P120P	HOXA3_ENST00000317201.2_Silent_p.P120P|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	120	Pro-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						AAGAGggaggcgggggcgcgg	0.731000													13	55					1.62849e-17	1.99291e-17	0.028581	1	0
KCNK9	51305	broad.mit.edu	37	8	140630669	140630669	+	Silent	SNP	G	G	A	rs140285421		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:140630669G>A	ENST00000520439.1	-	2	1020	c.957C>T	c.(955-957)agC>agT	p.S319S	KCNK9_ENST00000303015.1_Silent_p.S319S			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	319						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity	p.S319S(1)		NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CAAGCTTGGCGCTGAAGGAGT	0.577000													31	67					0	0	0.064281	0	0
MUC16	94025	broad.mit.edu	37	19	8969281	8969281	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:8969281C>A	ENST00000397910.4	-	79	43266	c.43063G>T	c.(43063-43065)Gat>Tat	p.D14355Y	MUC16_ENST00000380951.5_Missense_Mutation_p.D996Y	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14451	SEA 15.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCACCGCATCCTCAATATTC	0.473000													55	109					4.52765e-18	5.57004e-18	0.048971	1	0
TCL1A	8115	broad.mit.edu	37	14	96180345	96180345	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:96180345G>T	ENST00000402399.1	-	1	188	c.59C>A	c.(58-60)gCc>gAc	p.A20D	TCL1A_ENST00000555202.1_Missense_Mutation_p.A20D|TCL1A_ENST00000554012.1_Missense_Mutation_p.A20D|RP11-164H13.1_ENST00000547644.2_RNA|RP11-164H13.1_ENST00000553445.1_RNA|TCL1A_ENST00000556450.1_Missense_Mutation_p.A20D	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	20					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CTTCTCCCAGGCCCACAGGCG	0.652000			T	TRA@	T-CLL								45	89					9.40368e-32	1.23501e-31	0.048971	1	0
ELL	8178	broad.mit.edu	37	19	18561707	18561707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:18561707G>A	ENST00000262809.4	-	8	1116	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	349					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		ACGGCAGGCTGAGCTCTCTGA	0.627000			T	MLL	AL						OREG0025365	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	24					0	0	0.038147	0	0
USP34	9736	broad.mit.edu	37	2	61415551	61415551	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:61415551T>C	ENST00000398571.2	-	80	10403	c.10327A>G	c.(10327-10329)Aga>Gga	p.R3443G		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3443					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCGTCATATCTACCATTGTTG	0.398000													22	62					0	0	0.055883	0	0
PDIA2	64714	broad.mit.edu	37	16	335387	335387	+	Silent	SNP	C	C	A	rs139827174	by1000genomes	TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:335387C>A	ENST00000219406.6	+	6	889	c.871C>A	c.(871-873)Cgg>Agg	p.R291R	PDIA2_ENST00000404312.1_Silent_p.R288R|PDIA2_ENST00000462950.1_3'UTR	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	291					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GGCTGCGCACCGGGAGCTCCT	0.667000													22	27					2.89027e-11	3.30047e-11	0.069288	1	0
ZNF599	148103	broad.mit.edu	37	19	35251243	35251243	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:35251243C>T	ENST00000329285.7	-	4	836	c.463G>A	c.(463-465)Gat>Aat	p.D155N		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TCCAAATCATCATGTTTATAA	0.438000													41	103					0	0	0.039052	0	0
DSCAM	1826	broad.mit.edu	37	21	41450791	41450791	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:41450791C>G	ENST00000400454.1	-	26	5011	c.4534G>C	c.(4534-4536)Gag>Cag	p.E1512Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1512	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCCTGTACTCTAGTGTGAAG	0.552000													13	26					0	0	0.024245	0	0
TMEM39A	55254	broad.mit.edu	37	3	119180904	119180904	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:119180904C>G	ENST00000319172.5	-	2	438	c.18G>C	c.(16-18)agG>agC	p.R6S	TMEM39A_ENST00000486159.1_5'UTR	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	6						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		GACTAGGGCCCCTCCTTCCAC	0.522000													6	46					0	0	0.029380	0	0
HAVCR1	26762	broad.mit.edu	37	5	156464271	156464271	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:156464271G>A	ENST00000339252.3	-	6	1471	c.939C>T	c.(937-939)gtC>gtT	p.V313V	HAVCR1_ENST00000522693.1_Silent_p.V313V|HAVCR1_ENST00000523175.1_Silent_p.V313V|HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000544197.1_Silent_p.V313V|HAVCR1_ENST00000425854.1_Silent_p.V313V	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	308					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGCAATGATGACACCCAAAA	0.408000													41	92					0	0	0.048971	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32894000	32894000	+	RNA	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:32894000T>A	ENST00000330048.5	-	0	1257					NR_003083.2																						CAGGGCAGCGTGGTGCTAAAG	0.577000													5	48					0	0	0.021553	0	0
METTL22	79091	broad.mit.edu	37	16	8722634	8722634	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:8722634G>A	ENST00000381920.3	+	3	439	c.181G>A	c.(181-183)Gat>Aat	p.D61N	METTL22_ENST00000561758.1_Missense_Mutation_p.D61N	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	61							methyltransferase activity			large_intestine(5)|lung(4)	9						CTCTTGGACAGATTCAGGAGC	0.488000													21	59					0	0	0.076483	0	0
COL22A1	169044	broad.mit.edu	37	8	139736904	139736904	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:139736904G>T	ENST00000303045.6	-	25	2647	c.2201C>A	c.(2200-2202)cCt>cAt	p.P734H	COL22A1_ENST00000435777.1_Missense_Mutation_p.P734H	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	734	Collagen-like 5.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GATCTCTCCAGGCAAACCCTG	0.592000										HNSCC(7;0.00092)			27	40					2.68265e-12	3.08462e-12	0.054565	1	0
ITGAM	3684	broad.mit.edu	37	16	31340616	31340616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:31340616C>T	ENST00000544665.3	+	24	2934	c.2863C>T	c.(2863-2865)Caa>Taa	p.Q955*	ITGAM_ENST00000287497.8_Nonsense_Mutation_p.Q954*	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	954					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CATGCAGCATCAATATCAGGT	0.517000													20	13					0	0	0.021523	0	0
PCDH15	65217	broad.mit.edu	37	10	55591228	55591228	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:55591228C>T	ENST00000373965.2	-	31	4464	c.4070G>A	c.(4069-4071)cGc>cAc	p.R1357H	PCDH15_ENST00000395445.1_Missense_Mutation_p.R1357H|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.R1313H|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395433.1_Missense_Mutation_p.R1328H|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.R1355H|PCDH15_ENST00000320301.6_Missense_Mutation_p.R1350H|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.R1350H|PCDH15_ENST00000361849.3_Missense_Mutation_p.R1350H|PCDH15_ENST00000437009.1_Missense_Mutation_p.R1279H|PCDH15_ENST00000395438.1_Missense_Mutation_p.R1350H|PCDH15_ENST00000409834.1_Missense_Mutation_p.R961H|PCDH15_ENST00000395446.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1350					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.R1350H(2)|p.R1355H(2)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTCCAGAATGCGTCCTCCTTC	0.418000										HNSCC(58;0.16)			11	49					0	0	0.016723	0	0
AKAP6	9472	broad.mit.edu	37	14	33015051	33015051	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:33015051G>T	ENST00000280979.4	+	4	1362	c.1192G>T	c.(1192-1194)Gag>Tag	p.E398*	AKAP6_ENST00000557272.1_Nonsense_Mutation_p.E398*|AKAP6_ENST00000557354.1_Nonsense_Mutation_p.E398*	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	398					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTTTCTTAAAGAGGAAACTTT	0.428000													23	64					5.35356e-11	6.09348e-11	0.076483	1	0
BCMO1	53630	broad.mit.edu	37	16	81272546	81272546	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:81272546A>G	ENST00000258168.2	+	1	494	c.33A>G	c.(31-33)gaA>gaG	p.E11E	BCMO1_ENST00000564552.1_Silent_p.E11E|BCMO1_ENST00000425577.2_5'UTR	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	11					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						ATAGGAAAGAACAGCTGGAGC	0.428000													22	56					0	0	0.045705	0	0
GRAP	10750	broad.mit.edu	37	17	18927649	18927649	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:18927649C>T	ENST00000284154.5	-	4	1057	c.347G>A	c.(346-348)gGg>gAg	p.G116E	GRAP_ENST00000395635.1_Missense_Mutation_p.G87E|GRAP_ENST00000573099.1_Intron	NM_006613.3	NP_006604.1	Q13588	GRAP_HUMAN	GRB2-related adaptor protein	116	SH2.				cell-cell signaling|Ras protein signal transduction	cytoplasm	SH3/SH2 adaptor activity			large_intestine(1)|urinary_tract(1)	2	all_cancers(12;0.0183)					GAAGTACTTCCCCGAGGCCTC	0.617000													11	18					0	0	0.010729	0	0
PHYH	5264	broad.mit.edu	37	10	13337539	13337539	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:13337539C>G	ENST00000396920.3	-	3	549	c.145G>C	c.(145-147)Gta>Cta	p.V49L	PHYH_ENST00000396913.2_5'UTR|PHYH_ENST00000263038.4_Missense_Mutation_p.V68L			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	68					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTTTTGATTACTAGAAACCCA	0.323000													13	64					0	0	0.016723	0	0
EIF4E2	9470	broad.mit.edu	37	2	233421133	233421133	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:233421133G>A	ENST00000409514.1	+	2	70	c.28G>A	c.(28-30)Gat>Aat	p.D10N	EIF4E2_ENST00000409098.1_Missense_Mutation_p.D10N|EIF4E2_ENST00000479834.1_3'UTR|EIF4E2_ENST00000258416.3_Missense_Mutation_p.D10N|EIF4E2_ENST00000409495.1_Missense_Mutation_p.D10N|EIF4E2_ENST00000409167.3_Missense_Mutation_p.D10N|EIF4E2_ENST00000409394.1_Missense_Mutation_p.D10N|EIF4E2_ENST00000409322.1_Missense_Mutation_p.D10N			O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E family member 2	10				MNNKFDALKDDDSGDHDQNEENSTQKD -> MMTVGTMIRM KKTAHRKI (in Ref. 3; AAC39871).	regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CAGTTTGAAAGATGATGACAG	0.413000													6	22					0	0	0.029380	0	0
MMP21	118856	broad.mit.edu	37	10	127460821	127460821	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:127460821G>C	ENST00000368808.3	-	4	944	c.945C>G	c.(943-945)gaC>gaG	p.D315E		NM_147191.1	NP_671724.1	Q8N119	MMP21_HUMAN	matrix metallopeptidase 21	315					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	16		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGTCTGACCAGTCCAACTCAA	0.517000													22	74					0	0	0.076483	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171623	68171623	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:68171623G>T	ENST00000243457.3	+	2	826	c.443G>T	c.(442-444)aGa>aTa	p.R148I	KCNJ2_ENST00000535240.1_Missense_Mutation_p.R148I	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	148					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					TATGGTTTCAGATGTGTCACG	0.512000													80	36					9.07295e-45	1.21901e-44	0.048971	1	0
GPR37	2861	broad.mit.edu	37	7	124404368	124404368	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:124404368C>G	ENST00000303921.2	-	1	1313	c.663G>C	c.(661-663)caG>caC	p.Q221H		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	221						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						AGGATCCATTCTGGGCCAGCG	0.637000													23	53					0	0	0.021523	0	0
OR10T2	128360	broad.mit.edu	37	1	158368962	158368962	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:158368962C>T	ENST00000334438.1	-	1	294	c.295G>A	c.(295-297)Gcc>Acc	p.A99T		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					AGCTGGGTGGCACAGGCCATG	0.498000													19	27					0	0	0.049695	0	0
AHNAK	79026	broad.mit.edu	37	11	62287401	62287401	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:62287401C>T	ENST00000378024.4	-	5	14762	c.14488G>A	c.(14488-14490)Gca>Aca	p.A4830T	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4830				A -> P (in Ref. 2; AAA69898).	nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTCAGTTTTGCGTCTGGACCT	0.488000													46	99					0	0	0.048971	0	0
CLCA1	1179	broad.mit.edu	37	1	86959282	86959282	+	Splice_Site	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:86959282G>C	ENST00000234701.3	+	11	2031	c.1680_splice	c.e11+1	p.K560_splice	CLCA1_ENST00000394711.1_Splice_Site_p.K560_splice			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	560					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCATTGCTAAGGTATGGAGTC	0.388000													16	19					0	0	0.028581	0	0
LRRC55	219527	broad.mit.edu	37	11	56949704	56949704	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:56949704C>A	ENST00000497933.1	+	1	484	c.337C>A	c.(337-339)Ctc>Atc	p.L113I		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	83						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CACCCGAAACCTCAGCCTGGC	0.587000													23	41					1.80694e-10	2.0467e-10	0.041601	1	0
PRKG2	5593	broad.mit.edu	37	4	82126147	82126147	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:82126147C>A	ENST00000395578.1	-	2	171	c.55G>T	c.(55-57)Ggg>Tgg	p.G19W	PRKG2_ENST00000264399.1_Missense_Mutation_p.G19W|PRKG2_ENST00000418486.2_Missense_Mutation_p.G19W			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	19					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						GTGAGGTTCCCAGAGTGTCCA	0.498000													14	24					1.5739e-10	1.78562e-10	0.028581	1	0
BOC	91653	broad.mit.edu	37	3	112987214	112987214	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:112987214G>C	ENST00000495514.1	+	5	1149	c.445G>C	c.(445-447)Gcc>Ccc	p.A149P	BOC_ENST00000273395.4_Missense_Mutation_p.A149P|BOC_ENST00000355385.3_Missense_Mutation_p.A149P			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	149	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			AGCAGTCATTGCCTGCCACCT	0.572000													26	23					0	0	0.041601	0	0
SEMA3F	6405	broad.mit.edu	37	3	50223354	50223354	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:50223354C>T	ENST00000002829.3	+	16	2104	c.1620C>T	c.(1618-1620)gtC>gtT	p.V540V	SEMA3F_ENST00000413852.1_Silent_p.V441V|SEMA3F_ENST00000434342.1_Silent_p.V509V	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	540	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CCGTGGGTGTCACACACCTGA	0.642000													34	67					0	0	0.033182	0	0
GRB10	2887	broad.mit.edu	37	7	50671735	50671735	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:50671735C>T	ENST00000403097.1	-	16	2266	c.1486G>A	c.(1486-1488)Gaa>Aaa	p.E496K	GRB10_ENST00000398810.2_Missense_Mutation_p.E444K|GRB10_ENST00000357271.5_Missense_Mutation_p.E456K|GRB10_ENST00000439599.1_Missense_Mutation_p.E496K|GRB10_ENST00000335866.3_Missense_Mutation_p.E444K|GRB10_ENST00000401949.1_Missense_Mutation_p.E502K|GRB10_ENST00000402578.1_Missense_Mutation_p.E444K|GRB10_ENST00000402497.1_Missense_Mutation_p.E444K|GRB10_ENST00000407526.1_Missense_Mutation_p.E444K|GRB10_ENST00000406641.1_Missense_Mutation_p.E444K|GRB10_ENST00000398812.2_Missense_Mutation_p.E502K			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	502	SH2.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CTGTGGGATTCCTCCCTGGAG	0.532000									Russell-Silver syndrome				70	219					0	0	0.048971	0	0
DDX50	79009	broad.mit.edu	37	10	70706177	70706177	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:70706177G>C	ENST00000373585.3	+	15	2112	c.2005G>C	c.(2005-2007)Gat>Cat	p.D669H	DDX50_ENST00000466265.1_3'UTR	NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	669						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						AGAATATTATGATGGAAACAC	0.488000													14	49					0	0	0.024245	0	0
NMD3	51068	broad.mit.edu	37	3	160960298	160960298	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:160960298G>T	ENST00000460469.1	+	10	1329	c.874G>T	c.(874-876)Gca>Tca	p.A292S	NMD3_ENST00000351193.2_Missense_Mutation_p.A292S|NMD3_ENST00000472947.1_Missense_Mutation_p.A292S			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	292					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			ATTTTTAGTGGCAGATATTGA	0.333000													52	71					6.05568e-20	7.58314e-20	0.048971	1	0
POC1A	25886	broad.mit.edu	37	3	52130587	52130587	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:52130587G>C	ENST00000296484.2	-	10	1162	c.1123C>G	c.(1123-1125)Cag>Gag	p.Q375E	POC1A_ENST00000394970.2_Intron|POC1A_ENST00000474012.1_Missense_Mutation_p.Q337E	NM_015426.4	NP_056241.3	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	375						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						TGGCCTACCTGAGTGAGGACA	0.567000													71	71					0	0	0.048971	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983826	51983826	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:51983826G>T	ENST00000396477.4	+	2	313	c.292G>T	c.(292-294)Ggc>Tgc	p.G98C	CEACAM18_ENST00000451626.1_Missense_Mutation_p.G159C	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	159						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAACAGAGAAGGCAGCCTGTT	0.557000													16	46					1.37285e-15	1.63713e-15	0.028581	1	0
FRYL	285527	broad.mit.edu	37	4	48611798	48611798	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:48611798G>C	ENST00000537810.1	-	8	1058	c.454C>G	c.(454-456)Cta>Gta	p.L152V	FRYL_ENST00000507711.1_Missense_Mutation_p.L152V|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000358350.4_Missense_Mutation_p.L152V|FRYL_ENST00000503238.1_Missense_Mutation_p.L152V			O94915	FRYL_HUMAN	FRY-like	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GCTAAGTTTAGAACTTCATGA	0.303000													4	29					0	0	0.021553	0	0
HMHA1	23526	broad.mit.edu	37	19	1079762	1079762	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:1079762G>A	ENST00000313093.2	+	12	1666	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	HMHA1_ENST00000539243.2_Missense_Mutation_p.E495K|HMHA1_ENST00000586866.1_Missense_Mutation_p.E483K|HMHA1_ENST00000590214.1_Missense_Mutation_p.E506K|HMHA1_ENST00000543365.1_Missense_Mutation_p.E362K|HMHA1_ENST00000590577.1_Missense_Mutation_p.E114K|HMHA1_ENST00000536472.1_Missense_Mutation_p.E319K	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	479					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGAAGCAGGAGCTGGAGGA	0.687000													32	51					0	0	0.064281	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552615	140552615	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140552615G>T	ENST00000231137.3	+	1	373	c.199G>T	c.(199-201)Gtt>Ttt	p.V67F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		67	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTAGAATTGTTTCAGACCA	0.483000													18	46					2.4624e-09	2.75788e-09	0.049695	1	0
KRT25	147183	broad.mit.edu	37	17	38907553	38907553	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:38907553G>T	ENST00000312150.4	-	4	755	c.695C>A	c.(694-696)gCt>gAt	p.A232D		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	232	Linker 12.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				GTTGCCTCCAGCTGCGCACTG	0.542000													34	22					1.96642e-18	2.43197e-18	0.027894	1	0
LRP10	26020	broad.mit.edu	37	14	23341964	23341964	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:23341964C>G	ENST00000359591.4	+	2	743	c.52C>G	c.(52-54)Cca>Gca	p.P18A	LRP10_ENST00000546834.1_Missense_Mutation_p.P18A	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	18					endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TCTGGCCCATCCAGACCGGAT	0.547000											OREG0022588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	34					0	0	0.027356	0	0
ZNF528	84436	broad.mit.edu	37	19	52909814	52909814	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:52909814G>A	ENST00000391788.2	+	6	682	c.159G>A	c.(157-159)aaG>aaA	p.K53K	ZNF528_ENST00000360465.3_Silent_p.K63K|ZNF528_ENST00000598192.1_Silent_p.K63K|ZNF528_ENST00000594530.1_Silent_p.K63K			Q3MIS6	ZN528_HUMAN	zinc finger protein 528	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TAGAGCAAAAGAGAGATCCCT	0.478000													30	68					0	0	0.059317	0	0
DNAH10	196385	broad.mit.edu	37	12	124272447	124272447	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:124272447G>A	ENST00000409039.3	+	10	1360	c.1335G>A	c.(1333-1335)gaG>gaA	p.E445E		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	445	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCAAGATAGAGGCTTCGGGGA	0.562000													4	9					0	0	0.014758	0	0
FRAS1	80144	broad.mit.edu	37	4	79436952	79436952	+	Splice_Site	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:79436952G>A	ENST00000264895.6	+	66	10614		c.e66-1			NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1						cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTCCCTGGCAGAGGCAGGGTT	0.557000													19	47					0	0	0.043863	0	0
PCM1	5108	broad.mit.edu	37	8	17796323	17796323	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:17796323G>A	ENST00000325083.8	+	5	856	c.417G>A	c.(415-417)aaG>aaA	p.K139K	PCM1_ENST00000519253.1_Silent_p.K139K|PCM1_ENST00000518537.1_Silent_p.K139K|PCM1_ENST00000524226.1_Silent_p.K139K	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	139					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AAAACCGAAAGCCCTTCAACT	0.393000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								12	21					0	0	0.020292	0	0
SLC35G3	146861	broad.mit.edu	37	17	33521035	33521035	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:33521035G>C	ENST00000297307.5	-	1	377	c.292C>G	c.(292-294)Cct>Gct	p.P98A		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	98	DUF6 1.					integral to membrane											CGGATGTCAGGAGTTCCCAGA	0.602000													64	124					0	0	0.048971	0	0
KRT75	9119	broad.mit.edu	37	12	52827670	52827670	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:52827670G>T	ENST00000252245.5	-	1	639	c.419C>A	c.(418-420)cCc>cAc	p.P140H		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	140	Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CTGGATGGTGGGGTCGATTTG	0.597000													43	112					2.01872e-29	2.62171e-29	0.048971	1	0
SUCO	51430	broad.mit.edu	37	1	172579007	172579007	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:172579007G>C	ENST00000367723.3	+	23	3953	c.3829G>C	c.(3829-3831)Gaa>Caa	p.E1277Q	SUCO_ENST00000263688.3_Missense_Mutation_p.E1125Q	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		AAAGCCTGAAGAACCATTGCA	0.368000													40	37					0	0	0.048971	0	0
SAP30L	79685	broad.mit.edu	37	5	153833008	153833008	+	Missense_Mutation	SNP	G	G	T	rs148495748		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:153833008G>T	ENST00000297109.6	+	3	1019	c.371G>T	c.(370-372)cGa>cTa	p.R124L	SAP30L_ENST00000440364.2_Missense_Mutation_p.R83L|SAP30L_ENST00000426761.2_Missense_Mutation_p.R78L|SAP30L_ENST00000523198.1_3'UTR	NM_024632.5	NP_078908.1	Q9HAJ7	SP30L_HUMAN	SAP30-like	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|metal ion binding			breast(1)|lung(3)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CGTTATAAACGACACTACAAG	0.483000													39	61					1.8453e-21	2.31904e-21	0.039052	1	0
AP1M2	10053	broad.mit.edu	37	19	10692432	10692432	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:10692432G>A	ENST00000590923.1	-	4	473	c.390C>T	c.(388-390)atC>atT	p.I130I	AP1M2_ENST00000250244.6_Silent_p.I130I			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	130					cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			ACTCCTGCAGGATCTTGCTGT	0.602000													16	30					0	0	0.038395	0	0
OR5J2	282775	broad.mit.edu	37	11	55944812	55944812	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55944812C>A	ENST00000312298.1	+	1	719	c.719C>A	c.(718-720)aCc>aAc	p.T240N		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GCCTTCTCCACCTGTGCCTCT	0.468000													32	68					2.52637e-11	2.88964e-11	0.080422	1	0
KIF4B	285643	broad.mit.edu	37	5	154394711	154394711	+	Missense_Mutation	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:154394711A>T	ENST00000435029.4	+	1	1452	c.1292A>T	c.(1291-1293)aAc>aTc	p.N431I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	431					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAAAAACTGAACGCCAAGCTA	0.453000													32	65					0	0	0.074837	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220327347	220327347	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:220327347C>T	ENST00000358951.2	-	32	3724	c.3608G>A	c.(3607-3609)gGg>gAg	p.G1203E		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	1203					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		ATCCATTTCCCCACTAGGTAA	0.308000													5	195					0	0	0.021553	0	0
APOB	338	broad.mit.edu	37	2	21250865	21250865	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:21250865A>G	ENST00000233242.1	-	14	2029	c.1902T>C	c.(1900-1902)tcT>tcC	p.S634S	APOB_ENST00000399256.4_Silent_p.S634S	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	634	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATAGTTCCGAGAGAATTTTC	0.363000													37	82					0	0	0.030466	0	0
AE000661.37	0	broad.mit.edu	37	14	22928101	22928101	+	RNA	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:22928101C>T	ENST00000514473.2	-	0	225				TRDJ3_ENST00000390476.1_RNA																							TCCTGGGACACCCGACAGATG	0.537000													9	9					0	0	0.010729	0	0
USH2A	7399	broad.mit.edu	37	1	216246500	216246500	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:216246500G>A	ENST00000366943.2	-	28	6101	c.5715C>T	c.(5713-5715)tcC>tcT	p.S1905S	USH2A_ENST00000307340.3_Silent_p.S1905S|RP11-22M7.2_ENST00000446411.1_RNA|RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000430890.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1905	Fibronectin type-III 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAACCAGGATGGAGTCATTTC	0.473000										HNSCC(13;0.011)			20	23					0	0	0.049695	0	0
SERGEF	26297	broad.mit.edu	37	11	17981053	17981053	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:17981053C>T	ENST00000265965.5	-	9	1126	c.975G>A	c.(973-975)atG>atA	p.M325I	SERGEF_ENST00000528200.1_Intron|SERGEF_ENST00000532265.1_Intron	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	325					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						GAGACGAAGGCATGCTGTTCG	0.448000													20	53					0	0	0.076483	0	0
GCNT1	2650	broad.mit.edu	37	9	79117682	79117682	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:79117682G>T	ENST00000442371.1	+	3	1324	c.385G>T	c.(385-387)Gtt>Ttt	p.V129F	GCNT1_ENST00000444201.2_Missense_Mutation_p.V129F|GCNT1_ENST00000536223.1_Missense_Mutation_p.V129F|GCNT1_ENST00000376730.4_Missense_Mutation_p.V129F	NM_001097634.1	NP_001091103.1	Q02742	GCNT1_HUMAN	glucosaminyl (N-acetyl) transferase 1, core 2	129	Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(11)|prostate(2)|urinary_tract(1)	30						TTCTATAGTGGTTCATCACAA	0.408000													55	64					2.69953e-25	3.42953e-25	0.048971	1	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032559	46032559	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:46032559C>T	ENST00000334662.2	+	1	564	c.542C>T	c.(541-543)tCt>tTt	p.S181F	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	181	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						CCTGTCTGCTCTGGGGCTTCC	0.632000													97	257					0	0	0.048971	0	0
TTBK1	84630	broad.mit.edu	37	6	43251427	43251427	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:43251427C>T	ENST00000259750.4	+	14	3032	c.2949C>T	c.(2947-2949)ctC>ctT	p.L983L		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	983						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			AGAACGGCCTCGCCCTGTCAG	0.682000													20	39					0	0	0.049695	0	0
MDN1	23195	broad.mit.edu	37	6	90455280	90455280	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:90455280C>G	ENST00000369393.3	-	28	4085	c.3970G>C	c.(3970-3972)Gag>Cag	p.E1324Q	MDN1_ENST00000428876.1_Missense_Mutation_p.E1324Q			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1324					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAATGTTTCTCAAGGACTTCT	0.423000													19	71					0	0	0.055883	0	0
SEC22B	9554	broad.mit.edu	37	1	145115793	145115793	+	RNA	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:145115793G>A	ENST00000453618.1	+	0	879							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										GCCAGGATGCGAAGTACTTGA	0.398000													22	239					0	0	0.027356	0	0
ABCB11	8647	broad.mit.edu	37	2	169869891	169869891	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:169869891C>G	ENST00000263817.6	-	5	404	c.280G>C	c.(280-282)Gac>Cac	p.D94H		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	94	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism	p.D94N(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AACTCAACGTCGTAGTCAATA	0.428000													54	106					0	0	0.048971	0	0
PDE3A	5139	broad.mit.edu	37	12	20522876	20522876	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:20522876G>C	ENST00000359062.3	+	1	698	c.658G>C	c.(658-660)Gcg>Ccg	p.A220P	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	220					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTTGACTAGCGCGGTCAGGAC	0.657000													15	27					0	0	0.033300	0	0
CASR	846	broad.mit.edu	37	3	122003742	122003742	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:122003742G>A	ENST00000498619.1	+	7	3409	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	CASR_ENST00000490131.1_Missense_Mutation_p.E981K|CASR_ENST00000296154.5_Missense_Mutation_p.E981K	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	981					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GAGCTTTGATGAGCCTCAGAA	0.572000													18	68					0	0	0.038395	0	0
ALDH3A1	218	broad.mit.edu	37	17	19645475	19645475	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:19645475G>C	ENST00000457500.2	-	4	860	c.531C>G	c.(529-531)ctC>ctG	p.L177L	ALDH3A1_ENST00000444455.1_Silent_p.L177L|ALDH3A1_ENST00000395555.3_Silent_p.L177L|ALDH3A1_ENST00000225740.6_Silent_p.L177L|ALDH3A1_ENST00000494157.2_Silent_p.L104L	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	177					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	ACCTCTCCTTGAGCAGCTCCG	0.597000													31	79					0	0	0.080422	0	0
CACNG3	10368	broad.mit.edu	37	16	24373034	24373034	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:24373034C>A	ENST00000005284.3	+	4	2000	c.798C>A	c.(796-798)acC>acA	p.T266T		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	266					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CGATGTTCACCCTCTCCCGGG	0.577000													80	99					1.22797e-34	1.62799e-34	0.048971	1	0
KPTN	11133	broad.mit.edu	37	19	47986462	47986462	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:47986462C>T	ENST00000338134.3	-	4	512	c.405G>A	c.(403-405)ctG>ctA	p.L135L	KPTN_ENST00000595484.1_5'UTR|KPTN_ENST00000536339.1_5'UTR	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	135					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			breast(1)|lung(3)|ovary(2)|pancreas(2)	8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		GCTCCAGGTTCAGGCAGCTCT	0.612000													68	142					0	0	0.048971	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18165313	18165313	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:18165313C>G	ENST00000278816.2	+	10	2702	c.2052C>G	c.(2050-2052)atC>atG	p.I684M	CSRP2BP_ENST00000489634.2_Missense_Mutation_p.I556M|CSRP2BP_ENST00000435364.2_Missense_Mutation_p.I684M|CSRP2BP_ENST00000377681.2_Missense_Mutation_p.I683M			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	684	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						AAAAAGTCATCATTGCCTTTG	0.413000													28	70					0	0	0.030593	0	0
NYAP2	57624	broad.mit.edu	37	2	226446730	226446730	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:226446730G>C	ENST00000272907.6	+	4	1010	c.597G>C	c.(595-597)ccG>ccC	p.P199P	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	199																	AGCGAAATCCGAACACTCAGC	0.507000													55	105					0	0	0.048971	0	0
C10orf91	170393	broad.mit.edu	37	10	134261355	134261355	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:134261355G>A	ENST00000392630.3	+	3	289	c.228G>A	c.(226-228)acG>acA	p.T76T	C10orf91_ENST00000321248.2_Silent_p.T76T|C10orf91_ENST00000490765.1_3'UTR	NM_173541.2	NP_775812.1	Q5T1B1	CJ091_HUMAN	chromosome 10 open reading frame 91	76										endometrium(1)|kidney(1)|lung(1)|ovary(2)	5		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		CCCAGACCACGAGAGCGCTTT	0.627000													51	167					0	0	0.048971	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232577108	232577108	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:232577108G>A	ENST00000366630.1	-	13	3929	c.3571C>T	c.(3571-3573)Ctg>Ttg	p.L1191L	SIPA1L2_ENST00000308942.4_Silent_p.L265L|SIPA1L2_ENST00000262861.4_Silent_p.L1191L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1191					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TAGGAACCCAGGACTTTGGAA	0.408000													87	281					0	0	0.048971	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659359	176659359	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:176659359T>C	ENST00000367662.3	+	5	3388	c.2224T>C	c.(2224-2226)Tac>Cac	p.Y742H	PAPPA2_ENST00000367661.3_Missense_Mutation_p.Y742H	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	742	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCTGGGACTCTACCATGTCTT	0.522000													53	142					0	0	0.048971	0	0
PIH1D2	120379	broad.mit.edu	37	11	111941400	111941400	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:111941400G>C	ENST00000530641.1	-	5	898	c.573C>G	c.(571-573)agC>agG	p.S191R	PIH1D2_ENST00000532211.1_Missense_Mutation_p.S191R|PIH1D2_ENST00000431456.1_Missense_Mutation_p.S191R|PIH1D2_ENST00000280350.4_Missense_Mutation_p.S191R|PIH1D2_ENST00000528775.1_Missense_Mutation_p.S191R			Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2	191										endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		TCATAGTACTGCTTCGTATCT	0.363000													4	75					0	0	0.021553	0	0
WDFY3	23001	broad.mit.edu	37	4	85729562	85729562	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:85729562T>A	ENST00000322366.6	-	15	2761	c.2354A>T	c.(2353-2355)gAa>gTa	p.E785V	WDFY3_ENST00000295888.4_Missense_Mutation_p.E785V|WDFY3-AS1_ENST00000510449.1_RNA			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	785						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGGGATCTGTTCTGCACGACT	0.468000													51	92					0	0	0.048971	0	0
ALMS1	7840	broad.mit.edu	37	2	73676206	73676206	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:73676206C>G	ENST00000264448.6	+	8	2660	c.2549C>G	c.(2548-2550)cCa>cGa	p.P850R	ALMS1_ENST00000377715.1_Missense_Mutation_p.P850R|ALMS1_ENST00000409009.1_Missense_Mutation_p.P808R	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	850	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTGGGACACCAGCTGTAACC	0.498000													17	46					0	0	0.038395	0	0
TMEM145	284339	broad.mit.edu	37	19	42818843	42818843	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:42818843G>T	ENST00000598766.1	+	4	382	c.382G>T	c.(382-384)Ggc>Tgc	p.G128C	TMEM145_ENST00000601020.1_3'UTR|TMEM145_ENST00000301204.3_Missense_Mutation_p.G118C			Q8NBT3	TM145_HUMAN	transmembrane protein 145	118						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				TGCCTGGTCCGGCTGTCAGGT	0.622000													60	101					1.72039e-30	2.25098e-30	0.048971	1	0
UPB1	51733	broad.mit.edu	37	22	24898459	24898459	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:24898459G>A	ENST00000382760.2	+	4	681	c.519G>A	c.(517-519)ctG>ctA	p.L173L	UPB1_ENST00000413389.2_Intron|UPB1_ENST00000326010.5_Intron			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	0	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					gctcacctctggcttttgtaa	0.542000													104	61					0	0	0.048971	0	0
DTYMK	1841	broad.mit.edu	37	2	242626193	242626193	+	Silent	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:242626193C>A	ENST00000305784.2	-	1	213	c.6G>T	c.(4-6)gcG>gcT	p.A2A		NM_001165031.1|NM_012145.3	NP_001158503.1|NP_036277.2	P23919	KTHY_HUMAN	deoxythymidylate kinase (thymidylate kinase)	2					cell cycle|cell proliferation|nucleobase, nucleoside and nucleotide interconversion	cytosol	ATP binding|nucleoside phosphate kinase activity|thymidylate kinase activity			NS(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.6e-33)|all cancers(36;3.57e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.23e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CGCGCCGGGCCGCCATGACTG	0.706000													4	9					0.00024832	0.000259052	0.009096	1	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					9	70					0	0	0.049695	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725572	32725572	+	Silent	SNP	G	G	A	rs116284473	byFrequency	TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:32725572G>A	ENST00000435145.2	-	4	796	c.735C>T	c.(733-735)atC>atT	p.I245I	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Silent_p.I245I			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						TGTGACGGATGATAAGGCCCA	0.557000													3	23					0	0	0.004672	0	0
OC90	729330	broad.mit.edu	37	8	133053885	133053885	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:133053885G>A	ENST00000262283.5	-	8	918	c.819C>T	c.(817-819)atC>atT	p.I273I	OC90_ENST00000443356.2_Silent_p.I77I|OC90_ENST00000603859.1_Silent_p.I77I|OC90_ENST00000254627.3_Silent_p.I77I			Q02509	OC90_HUMAN	otoconin 90	77					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGACAAACTGGATCAGCACAG	0.567000													14	37					0	0	0.016723	0	0
LRFN2	57497	broad.mit.edu	37	6	40400156	40400156	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:40400156G>T	ENST00000338305.6	-	2	1239	c.697C>A	c.(697-699)Cca>Aca	p.P233T		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	233						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GACAAGGGTGGGGCAAAGGGT	0.602000													12	41					0.00010058	0.000105398	0.013537	1	0
OLFM1	10439	broad.mit.edu	37	9	138011958	138011958	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:138011958G>A	ENST00000252854.4	+	6	1525	c.1338G>A	c.(1336-1338)tgG>tgA	p.W446*	OLFM1_ENST00000371793.3_Nonsense_Mutation_p.W464*|OLFM1_ENST00000371796.3_Nonsense_Mutation_p.W437*	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	464	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TGTATGCCTGGAACAACGGCC	0.562000													34	154					0	0	0.080422	0	0
LRRC23	10233	broad.mit.edu	37	12	7015087	7015087	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:7015087C>G	ENST00000007969.8	+	3	425	c.205C>G	c.(205-207)Cat>Gat	p.H69D	LRRC23_ENST00000449039.1_Intron|LRRC23_ENST00000436789.1_Missense_Mutation_p.H69D|LRRC23_ENST00000429740.1_Missense_Mutation_p.H69D|LRRC23_ENST00000323702.5_Missense_Mutation_p.H69D|LRRC23_ENST00000443597.2_Missense_Mutation_p.H69D|LRRC23_ENST00000433346.1_Missense_Mutation_p.H69D	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	69										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						TGGGCTGGCTCATGCTTATGT	0.542000													23	55					0	0	0.030593	0	0
OR2G2	81470	broad.mit.edu	37	1	247752236	247752236	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:247752236G>T	ENST00000320065.1	+	1	575	c.575G>T	c.(574-576)tGt>tTt	p.C192F	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAGCTGGCTTGTGTGGGCACC	0.537000													54	78					1.0442e-30	1.3688e-30	0.048971	1	0
GRID1	2894	broad.mit.edu	37	10	87615890	87615890	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:87615890T>C	ENST00000327946.7	-	7	1094	c.1009A>G	c.(1009-1011)Aag>Gag	p.K337E		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	337						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCCTCCAGCTTCCTGTGAAAG	0.512000										Multiple Myeloma(13;0.14)			27	47					0	0	0.041601	0	0
ADPGK	83440	broad.mit.edu	37	15	73048727	73048727	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:73048727G>A	ENST00000311669.8	-	5	798	c.705C>T	c.(703-705)ctC>ctT	p.L235L	ADPGK_ENST00000567733.1_Intron	NM_031284.4	NP_112574.3	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	235	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)	7						CCCCGTTGGAGAGGTCGTGAG	0.532000													40	70					0	0	0.048971	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													7	127					0	0	0.038147	0	0
FCGBP	8857	broad.mit.edu	37	19	40433429	40433429	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:40433429A>G	ENST00000221347.6	-	2	847	c.840T>C	c.(838-840)caT>caC	p.H280H		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	280	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGATACCCCCATGGTTGTAGG	0.592000													17	40					0	0	0.049695	0	0
PCDHA9	9752	broad.mit.edu	37	5	140389491	140389491	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140389491G>T	ENST00000532602.1	+	4	3855	c.2822G>T	c.(2821-2823)gGg>gTg	p.G941V	PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Missense_Mutation_p.G941V|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.G677V|PCDHA10_ENST00000506939.2_Missense_Mutation_p.G676V|PCDHA2_ENST00000526136.1_Missense_Mutation_p.G939V|PCDHA7_ENST00000525929.1_Missense_Mutation_p.G928V|PCDHA5_ENST00000529859.1_Missense_Mutation_p.G927V|PCDHA11_ENST00000398640.2_Missense_Mutation_p.G940V|PCDHA10_ENST00000307360.5_Missense_Mutation_p.G939V|PCDHAC2_ENST00000289269.5_Missense_Mutation_p.G998V|PCDHA12_ENST00000398631.2_Missense_Mutation_p.G932V|PCDHA13_ENST00000289272.2_Missense_Mutation_p.G941V|PCDHA8_ENST00000531613.1_Missense_Mutation_p.G941V|PCDHA1_ENST00000504120.2_Missense_Mutation_p.G941V|PCDHA3_ENST00000522353.2_Missense_Mutation_p.G941V|PCDHA4_ENST00000530339.1_Missense_Mutation_p.G938V|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Missense_Mutation_p.G954V|PCDHA1_ENST00000394633.3_Missense_Mutation_p.G677V	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAGAGAAAGGGAACAGCACG	0.413000													25	77					4.72057e-08	5.18744e-08	0.021523	1	0
NSUN7	79730	broad.mit.edu	37	4	40810350	40810350	+	Nonstop_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:40810350G>C	ENST00000316607.5	+	11	1894	c.1427G>C	c.(1426-1428)tGa>tCa	p.*476S	NSUN7_ENST00000381782.2_Silent_p.V517V					NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						CAGTGTCTGTGAATGATGTTT	0.413000													7	117					0	0	0.058154	0	0
HERC2	8924	broad.mit.edu	37	15	28369251	28369251	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:28369251C>A	ENST00000261609.7	-	85	13228	c.13120G>T	c.(13120-13122)Gac>Tac	p.D4374Y		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4374					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCAGTTTCGTCGAGCGAGCCT	0.562000													30	69					8.88839e-20	1.11105e-19	0.045705	1	0
ULK2	9706	broad.mit.edu	37	17	19687055	19687055	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:19687055G>A	ENST00000395544.4	-	22	2914	c.2415C>T	c.(2413-2415)ctC>ctT	p.L805L	ULK2_ENST00000361658.2_Silent_p.L805L	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	805					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CAAAGGTGATGAGCCCCTCTA	0.552000													85	46					0	0	0.048971	0	0
AREL1	9870	broad.mit.edu	37	14	75131573	75131573	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:75131573A>G	ENST00000356357.4	-	18	2674	c.2159T>C	c.(2158-2160)gTa>gCa	p.V720A	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		ACCAACAACTACTGCATGGGC	0.418000													21	47					0	0	0.021523	0	0
TTN	7273	broad.mit.edu	37	2	179430662	179430662	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:179430662C>A	ENST00000589042.1	-	326	80421	c.80197G>T	c.(80197-80199)Gtg>Ttg	p.V26733L	TTN_ENST00000342992.6_Missense_Mutation_p.V24165L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V17668L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V17793L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V25092L|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V17860L|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25092	Ig-like 128.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACTACTCACATTAGCATAC	0.418000													25	65					8.24728e-16	9.86854e-16	0.024334	1	0
RANBP6	26953	broad.mit.edu	37	9	6012838	6012838	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:6012838C>G	ENST00000259569.5	-	1	2780	c.2770G>C	c.(2770-2772)Gat>Cat	p.D924H		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	924					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		GGGTTGTTATCTCGCATATTT	0.428000													12	44					0	0	0.016723	0	0
CHD5	26038	broad.mit.edu	37	1	6186638	6186638	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:6186638C>A	ENST00000262450.3	-	26	4171	c.4072G>T	c.(4072-4074)Gac>Tac	p.D1358Y	CHD5_ENST00000378021.1_Missense_Mutation_p.D215Y	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1358					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCACCCTGGTCCTCCTGGGAG	0.672000													29	44					1.22384e-17	1.50032e-17	0.054565	1	0
CHD7	55636	broad.mit.edu	37	8	61734601	61734601	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:61734601G>A	ENST00000423902.2	+	11	3333	c.2854G>A	c.(2854-2856)Gat>Aat	p.D952N	CHD7_ENST00000524602.1_Intron|CHD7_ENST00000525508.1_Missense_Mutation_p.D952N	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	952					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCCTGCTGATGATTGGAAGAA	0.388000													12	42					0	0	0.016723	0	0
SI	6476	broad.mit.edu	37	3	164767629	164767629	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:164767629G>A	ENST00000264382.3	-	14	1609	c.1547C>T	c.(1546-1548)tCa>tTa	p.S516L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	516	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCTTTTGTTGAACCTTGAAT	0.284000										HNSCC(35;0.089)			16	83					0	0	0.038395	0	0
ALOX12B	242	broad.mit.edu	37	17	7977019	7977019	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:7977019T>C	ENST00000319144.4	-	13	1971	c.1711A>G	c.(1711-1713)Atc>Gtc	p.I571V	ALOX12B_ENST00000577351.1_Intron	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	571	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CAGGTGTAGATGACTATAGTG	0.592000										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	24					0	0	0.018920	0	0
KIAA1549	57670	broad.mit.edu	37	7	138579145	138579145	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:138579145G>A	ENST00000440172.1	-	10	4023	c.3975C>T	c.(3973-3975)cgC>cgT	p.R1325R	KIAA1549_ENST00000422774.1_Silent_p.R1325R|KIAA1549_ENST00000242365.4_Silent_p.R1275R	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1325						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						GCTTGTCTGTGCGGCATAGTT	0.517000			O	BRAF	pilocytic astrocytoma								46	169					0	0	0.048971	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883904	19883904	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr16:19883904C>G	ENST00000300571.2	-	2	455	c.264G>C	c.(262-264)gaG>gaC	p.E88D	GPRC5B_ENST00000569479.1_Missense_Mutation_p.E88D|GPRC5B_ENST00000535671.1_Missense_Mutation_p.E88D|GPRC5B_ENST00000537135.1_Missense_Mutation_p.E114D|GPRC5B_ENST00000569847.1_Missense_Mutation_p.E88D	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	88										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						GGCTCTTCTTCTCCTTCTCCT	0.622000													10	55					0	0	0.013537	0	0
E2F1	1869	broad.mit.edu	37	20	32264541	32264541	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:32264541G>C	ENST00000343380.5	-	7	1450	c.1311C>G	c.(1309-1311)ttC>ttG	p.F437L		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	437	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						AGCCCTGTCAGAAATCCAGGG	0.627000													7	15					0	0	0.047766	0	0
MACF1	23499	broad.mit.edu	37	1	39888568	39888568	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:39888568A>C	ENST00000564288.1	+	60	16922	c.16145A>C	c.(16144-16146)cAg>cCg	p.Q5382P	MACF1_ENST00000289893.4_Missense_Mutation_p.Q3822P|MACF1_ENST00000545844.1_Missense_Mutation_p.Q3320P|MACF1_ENST00000317713.7_Missense_Mutation_p.Q3320P|MACF1_ENST00000567887.1_Missense_Mutation_p.Q5419P|MACF1_ENST00000372915.3_Missense_Mutation_p.Q5387P|MACF1_ENST00000539005.1_Missense_Mutation_p.Q3299P|MACF1_ENST00000361689.2_Missense_Mutation_p.Q3320P			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5387					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATCCAAGAACAGAAGGTAAGT	0.448000													12	27					0	0	0.016723	0	0
AEN	64782	broad.mit.edu	37	15	89169692	89169692	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:89169692G>C	ENST00000332810.3	+	2	403	c.252G>C	c.(250-252)ctG>ctC	p.L84L	AEN_ENST00000379231.3_Silent_p.L84L	NM_022767.3	NP_073604.3	Q8WTP8	AEN_HUMAN	apoptosis enhancing nuclease	84					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding	p.L84L(1)		NS(1)|kidney(1)|large_intestine(1)|lung(4)	7						AGCAGTGTCTGAGGGCTGGAT	0.637000													6	26					0	0	0.021553	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332432	22332432	+	RNA	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:22332432C>T	ENST00000558896.1	+	0	239																											AAGATTCTAACGTGACAGAAC	0.343000													4	39					0	0	0.009096	0	0
TACC2	10579	broad.mit.edu	37	10	123970110	123970110	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:123970110C>T	ENST00000369005.1	+	9	6510	c.6170C>T	c.(6169-6171)tCa>tTa	p.S2057L	TACC2_ENST00000369004.3_Missense_Mutation_p.S135L|TACC2_ENST00000358010.1_Missense_Mutation_p.S203L|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000360561.3_Missense_Mutation_p.S135L|TACC2_ENST00000515603.1_Missense_Mutation_p.S2012L|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000515273.1_Missense_Mutation_p.S2061L|TACC2_ENST00000513429.1_Missense_Mutation_p.S203L|TACC2_ENST00000368999.1_Missense_Mutation_p.S135L|TACC2_ENST00000453444.2_Missense_Mutation_p.S2061L|TACC2_ENST00000334433.3_Missense_Mutation_p.S2057L|TACC2_ENST00000260733.3_Missense_Mutation_p.S135L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2057						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTCGTGCCTCAGACGCTAAG	0.522000													27	58					0	0	0.037714	0	0
POU6F2	11281	broad.mit.edu	37	7	39125535	39125535	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:39125535G>A	ENST00000518318.2	+	2	136	c.94G>A	c.(94-96)Gag>Aag	p.E32K	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000559001.1_Missense_Mutation_p.E24K|POU6F2_ENST00000464276.2_Missense_Mutation_p.E24K|POU6F2_ENST00000403058.1_Missense_Mutation_p.E32K			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	32					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GTTGAGAGGTGAGGACAAGGC	0.527000													13	45					0	0	0.038395	0	0
CNTN5	53942	broad.mit.edu	37	11	99690455	99690455	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:99690455C>G	ENST00000524871.1	+	4	526	c.236C>G	c.(235-237)cCc>cGc	p.P79R	CNTN5_ENST00000418526.2_Intron|CNTN5_ENST00000279463.3_Missense_Mutation_p.P79R|CNTN5_ENST00000528682.1_Missense_Mutation_p.P79R|CNTN5_ENST00000527185.1_Missense_Mutation_p.P79R	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	79					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TATTATTCCCCCATCAATCTT	0.428000													6	12					0	0	0.021553	0	0
WDR77	79084	broad.mit.edu	37	1	111986713	111986713	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:111986713G>A	ENST00000235090.5	-	5	733	c.527C>T	c.(526-528)tCt>tTt	p.S176F	WDR77_ENST00000411751.2_Missense_Mutation_p.S112F|WDR77_ENST00000497278.1_5'UTR	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	176					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTTGTGAGGAGAGGCAGCAAC	0.468000													12	68					0	0	0.016723	0	0
GABRG1	2565	broad.mit.edu	37	4	46067385	46067385	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:46067385G>C	ENST00000295452.4	-	4	705	c.538C>G	c.(538-540)Cta>Gta	p.L180V		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	180					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TATTACCTTAGAGTATACAGA	0.313000													16	30					0	0	0.028581	0	0
LMTK2	22853	broad.mit.edu	37	7	97822874	97822874	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:97822874G>A	ENST00000297293.5	+	11	3390	c.3097G>A	c.(3097-3099)Gaa>Aaa	p.E1033K		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	1033					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CAGTGGCTACGAAACAGAGAA	0.607000													25	84					0	0	0.034045	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49662178	49662178	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:49662178C>T	ENST00000249601.4	-	7	1115	c.819G>A	c.(817-819)gtG>gtA	p.V273V	ARHGAP22_ENST00000417912.2_Silent_p.V289V|ARHGAP22_ENST00000435790.2_Silent_p.V279V|ARHGAP22_ENST00000417247.2_Silent_p.V183V|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000374172.1_Silent_p.V164V	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	273	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GAAGGTTGCTCACTTGTTTAG	0.527000													41	81					0	0	0.048971	0	0
ASAP1	50807	broad.mit.edu	37	8	131073214	131073214	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:131073214G>C	ENST00000357668.1	-	27	2830	c.2803C>G	c.(2803-2805)Cca>Gca	p.P935A	ASAP1_ENST00000518721.1_Missense_Mutation_p.P935A			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	935	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						TCTCCAGGTGGTGGCTTTTGT	0.547000													51	131					0	0	0.048971	0	0
OSBP	5007	broad.mit.edu	37	11	59367987	59367987	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:59367987G>C	ENST00000263847.1	-	7	1772	c.1293C>G	c.(1291-1293)ctC>ctG	p.L431L		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	431	Sterol binding (By similarity).				lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGATCTTAGAGAGTTCTTTTC	0.478000													7	158					0	0	0.069234	0	0
FN1	2335	broad.mit.edu	37	2	216286823	216286823	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:216286823G>A	ENST00000354785.4	-	10	1906	c.1537C>T	c.(1537-1539)Cag>Tag	p.Q513*	FN1_ENST00000443816.1_Nonsense_Mutation_p.Q513*|FN1_ENST00000346544.3_Nonsense_Mutation_p.Q513*|FN1_ENST00000421182.1_Nonsense_Mutation_p.Q513*|FN1_ENST00000359671.1_Nonsense_Mutation_p.Q513*|FN1_ENST00000357867.4_Nonsense_Mutation_p.Q513*|FN1_ENST00000357009.2_Nonsense_Mutation_p.Q513*|FN1_ENST00000356005.4_Nonsense_Mutation_p.Q513*|FN1_ENST00000345488.5_Nonsense_Mutation_p.Q513*|FN1_ENST00000336916.4_Nonsense_Mutation_p.Q513*|FN1_ENST00000323926.6_Nonsense_Mutation_p.Q513*|FN1_ENST00000446046.1_Nonsense_Mutation_p.Q513*|FN1_ENST00000426059.1_Nonsense_Mutation_p.Q513*|FN1_ENST00000432072.2_Nonsense_Mutation_p.Q513*			P02751	FINC_HUMAN	fibronectin 1	513	Collagen-binding.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTCGAAGCTGCGAGTAGGCA	0.448000													50	111					0	0	0.048971	0	0
CELSR3	1951	broad.mit.edu	37	3	48688384	48688384	+	Missense_Mutation	SNP	C	C	A	rs2171560		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:48688384C>A	ENST00000544264.1	-	15	6591	c.6311G>T	c.(6310-6312)gGc>gTc	p.G2104V	CELSR3_ENST00000164024.4_Missense_Mutation_p.G2104V			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2104	Laminin EGF-like.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCACTGGCGGCCAAGGGCTCC	0.662000													42	34					2.43468e-25	3.09868e-25	0.048971	1	0
BAGE2	85319	broad.mit.edu	37	21	11049547	11049547	+	RNA	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr21:11049547C>G	ENST00000470054.1	-	0	561									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTGCTGACCACAAGTAGTA	0.448000													4	122					0	0	0.014758	0	0
MYO15A	51168	broad.mit.edu	37	17	18023816	18023816	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:18023816C>T	ENST00000205890.5	+	2	2040	c.1702C>T	c.(1702-1704)Cct>Tct	p.P568S		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	568	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CGTGCCTCGCCCTGCCACCTC	0.746000													7	6					0	0	0.029380	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517795	158517795	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:158517795G>A	ENST00000302617.3	-	1	100	c.101C>T	c.(100-102)tCc>tTc	p.S34F		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CAGGAAAATGGAGAAAAAGAG	0.443000													23	18					0	0	0.018920	0	0
C20orf85	128602	broad.mit.edu	37	20	56728612	56728612	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:56728612G>A	ENST00000371168.3	+	2	142	c.81G>A	c.(79-81)ctG>ctA	p.L27L		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	27										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AATACCGTCTGAAGGCTGAAT	0.473000													105	115					0	0	0.048971	0	0
GABBR2	9568	broad.mit.edu	37	9	101304157	101304157	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:101304157C>T	ENST00000259455.2	-	3	1087	c.628G>A	c.(628-630)Gag>Aag	p.E210K	GABBR2_ENST00000477471.1_5'UTR	NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	210					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GAGCGTACCTCAGAGAACCTC	0.547000													15	41					0	0	0.033300	0	0
SLC4A8	9498	broad.mit.edu	37	12	51865208	51865208	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:51865208C>T	ENST00000453097.2	+	14	2013	c.1796C>T	c.(1795-1797)tCc>tTc	p.S599F	SLC4A8_ENST00000394856.1_Missense_Mutation_p.S546F|SLC4A8_ENST00000358657.3_Missense_Mutation_p.S626F|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000535225.2_Missense_Mutation_p.S546F|SLC4A8_ENST00000514353.3_Missense_Mutation_p.S546F	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	599					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GCATTTGCCTCCCTAATTTGC	0.468000													24	83					0	0	0.024334	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375045	113375045	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:113375045G>A	ENST00000316407.4	-	7	5894	c.5484C>T	c.(5482-5484)ctC>ctT	p.L1828L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Silent_p.L1828L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1828					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						CCTGATCACTGAGGTGAGGGG	0.468000													43	143					0	0	0.045515	0	0
POLA1	5422	broad.mit.edu	37	X	24766437	24766437	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:24766437C>G	ENST00000379068.3	+	25	2744	c.2701C>G	c.(2701-2703)Caa>Gaa	p.Q901E	POLA1_ENST00000379059.3_Missense_Mutation_p.Q895E			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	895					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	GGATGGAGAACAAGAACAGAT	0.393000													12	5					0	0	0.020292	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170113	70170113	+	Splice_Site	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:70170113G>T	ENST00000342745.4	+	3	436	c.121_splice	c.e3-1	p.V41_splice		NM_014734.3	NP_055549.1	Q92537	K0247_HUMAN	KIAA0247	41	Sushi.					integral to membrane				endometrium(1)|kidney(1)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)	10				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		TCTTTGCAGTGTGCCCCCTAC	0.592000													37	114					5.73435e-26	7.3249e-26	0.048971	1	0
HOXD3	3232	broad.mit.edu	37	2	177036264	177036264	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:177036264G>C	ENST00000468418.3	+	4	2651	c.561G>C	c.(559-561)aaG>aaC	p.K187N	HOXD3_ENST00000410016.1_Missense_Mutation_p.K187N|HOXD3_ENST00000249440.3_Missense_Mutation_p.K187N			P31249	HXD3_HUMAN	homeobox D3	187					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GCGAGGACAAGAGCCCGCCAG	0.637000													17	27					0	0	0.033300	0	0
HPN	3249	broad.mit.edu	37	19	35556566	35556566	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:35556566G>A	ENST00000262626.2	+	11	1856	c.1031G>A	c.(1030-1032)gGt>gAt	p.G344D	HPN_ENST00000392226.1_Missense_Mutation_p.G344D|HPN_ENST00000597419.1_Missense_Mutation_p.G186D|HPN-AS1_ENST00000392227.2_RNA	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	344	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	TACCCCGAGGGTGGCATTGAT	0.602000													6	103					0	0	0.038147	0	0
ELN	2006	broad.mit.edu	37	7	73470702	73470702	+	Missense_Mutation	SNP	G	G	T	rs142438174		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:73470702G>T	ENST00000252034.7	+	20	1651	c.1252G>T	c.(1252-1254)Gca>Tca	p.A418S	ELN_ENST00000414324.1_Missense_Mutation_p.A413S|ELN_ENST00000380553.4_Missense_Mutation_p.A301S|ELN_ENST00000380562.4_Missense_Mutation_p.A418S|ELN_ENST00000380575.4_Missense_Mutation_p.A408S|ELN_ENST00000380576.5_Missense_Mutation_p.A418S|ELN_ENST00000380584.4_Missense_Mutation_p.A404S|ELN_ENST00000358929.4_Missense_Mutation_p.A418S|ELN_ENST00000357036.5_Missense_Mutation_p.A423S|ELN_ENST00000320399.6_Missense_Mutation_p.A418S|ELN_ENST00000458204.1_Missense_Mutation_p.A408S|ELN_ENST00000320492.7_Intron|ELN_ENST00000445912.1_Missense_Mutation_p.A418S|ELN_ENST00000429192.1_Missense_Mutation_p.A423S	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	418	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding	p.A418T(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CCCTGGAGTCGCAGGTGTCCC	0.627000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						62	170					1.65906e-26	2.12311e-26	0.048971	1	0
TNC	3371	broad.mit.edu	37	9	117848184	117848184	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr9:117848184C>T	ENST00000350763.4	-	3	2237	c.1826G>A	c.(1825-1827)tGc>tAc	p.C609Y	TNC_ENST00000423613.2_Missense_Mutation_p.C609Y|TNC_ENST00000341037.4_Missense_Mutation_p.C609Y|TNC_ENST00000535648.1_Missense_Mutation_p.C609Y|TNC_ENST00000537320.1_Missense_Mutation_p.C609Y|TNC_ENST00000346706.3_Missense_Mutation_p.C609Y|TNC_ENST00000542877.1_Missense_Mutation_p.C609Y|TNC_ENST00000340094.3_Missense_Mutation_p.C609Y|TNC_ENST00000345230.3_Missense_Mutation_p.C609Y	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	609	EGF-like 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GTTGCAGATGCAGCGGCCCGA	0.597000													50	14					0	0	0.048971	0	0
NLRP9	338321	broad.mit.edu	37	19	56244602	56244602	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:56244602G>T	ENST00000332836.2	-	2	622	c.595C>A	c.(595-597)Ctg>Atg	p.L199M		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	199	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGGAGCTCCAGTAAGCTGGTC	0.473000													7	18					3.09899e-07	3.35284e-07	0.047766	1	0
XIRP1	165904	broad.mit.edu	37	3	39226540	39226540	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:39226540C>T	ENST00000340369.3	-	2	4625	c.4397G>A	c.(4396-4398)aGa>aAa	p.R1466K	XIRP1_ENST00000421646.1_Missense_Mutation_p.R149K|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1466							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TTTCTGGTTTCTTTGCAGACT	0.637000													32	37					0	0	0.054565	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33881259	33881259	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:33881259C>A	ENST00000504830.1	-	2	789	c.454G>T	c.(454-456)Gtt>Ttt	p.V152F	ADAMTS12_ENST00000515401.1_Missense_Mutation_p.V152F|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.V152F	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	152					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GCCGTCCCAACTCTGGTGCCC	0.587000										HNSCC(64;0.19)			20	144					1.87028e-06	1.99877e-06	0.062417	1	0
TCTN2	79867	broad.mit.edu	37	12	124192153	124192153	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:124192153G>T	ENST00000303372.5	+	18	2115	c.1987G>T	c.(1987-1989)Gag>Tag	p.E663*	TCTN2_ENST00000426174.2_Nonsense_Mutation_p.E662*|RP11-338K17.8_ENST00000538837.1_lincRNA	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	663					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TTTTTCAGGGGAGCTGCATTC	0.453000													18	22					3.99206e-14	4.6574e-14	0.043863	1	0
ATP10B	23120	broad.mit.edu	37	5	160047578	160047578	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:160047578G>C	ENST00000327245.5	-	15	3038	c.2192C>G	c.(2191-2193)gCc>gGc	p.A731G	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	731					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTAGGCATGGGCAGCGTGCAC	0.647000													15	38					0	0	0.038395	0	0
PRKD2	25865	broad.mit.edu	37	19	47197300	47197300	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:47197300C>G	ENST00000433867.1	-	11	1885	c.1408G>C	c.(1408-1410)Gtc>Ctc	p.V470L	PRKD2_ENST00000601806.1_Missense_Mutation_p.V313L|PRKD2_ENST00000595515.1_Missense_Mutation_p.V470L|PRKD2_ENST00000291281.4_Missense_Mutation_p.V470L|PRKD2_ENST00000600194.1_Missense_Mutation_p.V313L	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	470	PH.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TTGGCAGTGACGATCTCAAAG	0.652000													25	56					0	0	0.030593	0	0
IL23R	149233	broad.mit.edu	37	1	67635043	67635043	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:67635043G>T	ENST00000347310.5	+	3	260	c.89G>T	c.(88-90)tGc>tTc	p.C30F	IL23R_ENST00000371002.1_Missense_Mutation_p.C30F|C1orf141_ENST00000371007.2_Intron	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	30					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						AATATAAACTGCTCTGGCCAC	0.313000													13	42					1.49906e-05	1.58272e-05	0.020292	1	0
CLVS1	157807	broad.mit.edu	37	8	62412051	62412051	+	Missense_Mutation	SNP	G	G	A	rs35623706		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:62412051G>A	ENST00000519846.1	+	7	1487	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	CLVS1_ENST00000325897.4_Missense_Mutation_p.E339K|CLVS1_ENST00000518592.1_Missense_Mutation_p.E60K|CLVS1_ENST00000518858.1_3'UTR			Q8IUQ0	CLVS1_HUMAN	clavesin 1	339					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CCTGAAACATGAGGAGAAGGG	0.498000													19	67					0	0	0.069288	0	0
SCAND3	114821	broad.mit.edu	37	6	28540642	28540642	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:28540642C>G	ENST00000452236.2	-	4	3641	c.3024G>C	c.(3022-3024)atG>atC	p.M1008I		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1008					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						atatttttttcatggcaagac	0.299000													26	68					0	0	0.027356	0	0
RHOJ	57381	broad.mit.edu	37	14	63735882	63735882	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:63735882G>T	ENST00000316754.3	+	2	695	c.233G>T	c.(232-234)gGa>gTa	p.G78V	RHOJ_ENST00000557133.1_3'UTR|RHOJ_ENST00000555125.1_Missense_Mutation_p.G78V	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	78					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		GACACCGCGGGACAGGTACAT	0.448000													18	64					0.000295444	0.000307754	0.069288	1	0
TCOF1	6949	broad.mit.edu	37	5	149758943	149758943	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:149758943G>T	ENST00000451292.1	+	16	2738	c.2630G>T	c.(2629-2631)aGt>aTt	p.S877I	TCOF1_ENST00000504761.2_Missense_Mutation_p.S877I|TCOF1_ENST00000439160.2_Missense_Mutation_p.S877I|TCOF1_ENST00000323668.7_Missense_Mutation_p.S800I|TCOF1_ENST00000506063.1_3'UTR|TCOF1_ENST00000394269.3_Missense_Mutation_p.S877I|TCOF1_ENST00000445265.2_Missense_Mutation_p.S800I|TCOF1_ENST00000377797.3_Missense_Mutation_p.S877I|TCOF1_ENST00000513346.1_Missense_Mutation_p.S877I			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	877					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGTCAGACAGTGAGGAGGAG	0.607000													15	29					5.01169e-05	5.27547e-05	0.033300	1	0
NELL2	4753	broad.mit.edu	37	12	45209864	45209864	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:45209864C>T	ENST00000429094.2	-	3	744	c.240G>A	c.(238-240)aaG>aaA	p.K80K	NELL2_ENST00000551601.1_Silent_p.K79K|NELL2_ENST00000548826.1_Silent_p.K80K|NELL2_ENST00000547172.1_5'UTR|NELL2_ENST00000395487.2_Silent_p.K79K|NELL2_ENST00000333837.4_Silent_p.K103K|NELL2_ENST00000452445.2_Silent_p.K80K|NELL2_ENST00000437801.2_Silent_p.K130K|NELL2_ENST00000549027.1_Silent_p.K79K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	80	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TATTTCTCAGCTTCTGAAAAA	0.333000													7	103					0	0	0.047766	0	0
DDX27	55661	broad.mit.edu	37	20	47835954	47835954	+	Missense_Mutation	SNP	T	T	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:47835954T>G	ENST00000371764.4	+	1	71	c.62T>G	c.(61-63)gTg>gGg	p.V21G	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	21						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCGCAGGCTGTGCTCGCTTCC	0.622000													20	35					0	0	0.055883	0	0
TBATA	219793	broad.mit.edu	37	10	72539364	72539364	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:72539364G>A	ENST00000299290.1	-	5	801	c.412C>T	c.(412-414)Ccc>Tcc	p.P138S	TBATA_ENST00000545575.1_Missense_Mutation_p.P128S|TBATA_ENST00000456372.2_Missense_Mutation_p.P138S	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		GAAAGCTGGGGGTTCCGATTA	0.582000													20	30					0	0	0.062417	0	0
HYOU1	10525	broad.mit.edu	37	11	118926253	118926253	+	Silent	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:118926253C>G	ENST00000404233.3	-	4	340	c.216G>C	c.(214-216)gtG>gtC	p.V72V	HYOU1_ENST00000543287.1_5'UTR|HYOU1_ENST00000529972.1_Silent_p.V72V|HYOU1_ENST00000525859.1_Silent_p.V72V	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	72						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CTTTCAGGGTCACGATCACCG	0.532000													20	81					0	0	0.021523	0	0
PRMT3	10196	broad.mit.edu	37	11	20483592	20483592	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:20483592T>C	ENST00000331079.6	+	12	1356	c.1139T>C	c.(1138-1140)aTt>aCt	p.I380T	PRMT3_ENST00000437750.2_Missense_Mutation_p.I318T	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	380							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						GCTGATAGAATTGCTTTTTGG	0.388000													36	77					0	0	0.074837	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202977	140202977	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:140202977G>C	ENST00000529859.1	+	1	1617	c.1617G>C	c.(1615-1617)gcG>gcC	p.A539A	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Silent_p.A539A|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.A539A	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGACGCGGGCGTGCCGC	0.692000													43	59					0	0	0.048971	0	0
BMPR1A	657	broad.mit.edu	37	10	88659610	88659610	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:88659610C>G	ENST00000372037.2	+	6	930	c.393C>G	c.(391-393)aaC>aaG	p.N131K		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	131					BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						ATTTATGTAACCAGTATTTGC	0.413000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				3	104					0	0	0.014758	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798703	55798703	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:55798703C>A	ENST00000313555.1	+	1	809	c.809C>A	c.(808-810)aCt>aAt	p.T270N		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					TCCCTAGACACTGATAAGGTG	0.398000													15	45					7.93312e-07	8.51715e-07	0.020292	1	0
ZNF765	91661	broad.mit.edu	37	19	53911769	53911769	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:53911769C>T	ENST00000396408.3	+	4	1078	c.961C>T	c.(961-963)Cat>Tat	p.H321Y	ZNF765_ENST00000594030.1_Intron	NM_001040185.1	NP_001035275.1	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(3)	4				GBM - Glioblastoma multiforme(134;0.00379)		TAGGAGAATTCATACTGGAGA	0.403000													27	87					0	0	0.027356	0	0
SART1	9092	broad.mit.edu	37	11	65733911	65733911	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:65733911G>A	ENST00000312397.5	+	9	1164	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N		NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	358					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CGGCACGGCTGATGGCCTGCG	0.642000													23	51					0	0	0.021523	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84527563	84527563	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:84527563G>A	ENST00000286744.5	+	8	997	c.773G>A	c.(772-774)aGa>aAa	p.R258K	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.R258K	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	258						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CGAAGTGTGAGAATTACAGTG	0.358000													33	71					0	0	0.027894	0	0
PLCB3	5331	broad.mit.edu	37	11	64023072	64023072	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:64023072G>T	ENST00000540288.1	+	7	684	c.581G>T	c.(580-582)gGc>gTc	p.G194V	PLCB3_ENST00000325234.5_Missense_Mutation_p.G127V|PLCB3_ENST00000279230.6_Missense_Mutation_p.G194V	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	194					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GAATCCTGTGGCCTCAAATTC	0.637000													50	83					2.48254e-18	3.06487e-18	0.048971	1	0
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:7578235T>C	ENST00000420246.2	-	6	746	c.614A>G	c.(613-615)tAt>tGt	p.Y205C	TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Missense_Mutation_p.Y205C|TP53_ENST00000445888.2_Missense_Mutation_p.Y205C|TP53_ENST00000455263.2_Missense_Mutation_p.Y205C|TP53_ENST00000359597.4_Missense_Mutation_p.Y205C|TP53_ENST00000269305.4_Missense_Mutation_p.Y205C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	205	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(68)|p.Y205S(14)|p.Y205F(8)|p.0?(8)|p.Y112C(5)|p.?(5)|p.Y73C(5)|p.Y73S(1)|p.Y112S(1)|p.E204fs*39(1)|p.E204_N210delEYLDDRN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	26					0	0	0.024245	0	0
TRPA1	8989	broad.mit.edu	37	8	72936057	72936057	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:72936057C>T	ENST00000262209.4	-	26	3348	c.3141G>A	c.(3139-3141)caG>caA	p.Q1047Q	RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	1047						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	ACCGGTATTTCTGCTTTAATA	0.259000													26	51					0	0	0.024334	0	0
SULF2	55959	broad.mit.edu	37	20	46290572	46290572	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:46290572C>T	ENST00000359930.4	-	18	3290	c.2439G>A	c.(2437-2439)ctG>ctA	p.L813L	SULF2_ENST00000467815.1_Silent_p.L813L|SULF2_ENST00000484875.1_Silent_p.L813L|SULF2_ENST00000361612.4_Silent_p.L813L	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	813					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						TGCAGCTCCTCAGCTCCATGA	0.547000													31	137					0	0	0.054565	0	0
CDK16	5127	broad.mit.edu	37	X	47086599	47086599	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:47086599G>A	ENST00000457458.2	+	13	1699	c.1279G>A	c.(1279-1281)Gac>Aac	p.D427N	CDK16_ENST00000357227.4_Missense_Mutation_p.D421N|CDK16_ENST00000276052.6_Missense_Mutation_p.D495N|CDK16_ENST00000518022.1_Missense_Mutation_p.D421N	NM_033018.3	NP_148978.2	Q00536	CDK16_HUMAN	cyclin-dependent kinase 16	421	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding	p.D421N(1)|p.D495N(1)		breast(1)|endometrium(3)|large_intestine(4)|lung(3)	11						CGACGGGGCCGACCTCCTCAC	0.582000													9	7					0	0	0.016723	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995839	57995839	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:57995839A>G	ENST00000316770.2	-	1	551	c.509T>C	c.(508-510)cTg>cCg	p.L170P		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				GCAAAAGGGCAGGGTGAAGAT	0.652000													13	24					0	0	0.020292	0	0
SYT7	9066	broad.mit.edu	37	11	61295611	61295611	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:61295611C>G	ENST00000263846.4	-	5	725	c.398G>C	c.(397-399)cGa>cCa	p.R133P	SYT7_ENST00000542836.1_Missense_Mutation_p.R177P|SYT7_ENST00000542670.1_Missense_Mutation_p.R341P|SYT7_ENST00000540677.1_Missense_Mutation_p.R208P|SYT7_ENST00000539008.1_Missense_Mutation_p.R416P|SYT7_ENST00000535826.1_Missense_Mutation_p.R252P|SYT7_ENST00000540831.1_5'UTR	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	133						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CAGGTTCTCTCGGCTGCAACC	0.647000													40	71					0	0	0.048971	0	0
HCN1	348980	broad.mit.edu	37	5	45645327	45645327	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:45645327C>T	ENST00000303230.4	-	2	866	c.809G>A	c.(808-810)cGa>cAa	p.R270Q		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	270						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCTTGAAAGTCGTAATAAACG	0.328000													9	23					0	0	0.058154	0	0
KMT2C	58508	broad.mit.edu	37	7	151962220	151962220	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:151962220C>G	ENST00000355193.2	-	8	1305	c.1087G>C	c.(1087-1089)Ggt>Cgt	p.G363R	KMT2C_ENST00000262189.6_Missense_Mutation_p.G363R					lysine (K)-specific methyltransferase 2C																		TAGTGCTGACCACAAGTAGTA	0.448000													15	517					0	0	0.055883	0	0
C9	735	broad.mit.edu	37	5	39331837	39331837	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:39331837C>T	ENST00000263408.4	-	5	651	c.556G>A	c.(556-558)Gat>Aat	p.D186N	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	186	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GTGTTTCCATCCCGATCCCGG	0.438000													45	202					0	0	0.048971	0	0
CD22	933	broad.mit.edu	37	19	35823807	35823807	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:35823807G>C	ENST00000085219.5	+	3	458	c.392G>C	c.(391-393)cGa>cCa	p.R131P	CD22_ENST00000270311.6_Missense_Mutation_p.R11P|CD22_ENST00000536635.2_Missense_Mutation_p.R131P|CD22_ENST00000341773.6_Missense_Mutation_p.R131P|CD22_ENST00000544992.2_Missense_Mutation_p.R131P|CD22_ENST00000594250.1_Missense_Mutation_p.R131P|CD22_ENST00000595419.1_3'UTR|CD22_ENST00000419549.2_5'UTR	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	131	Ig-like V-type.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGGATGGAACGAATACACCTC	0.552000													25	58					0	0	0.034045	0	0
SLC25A40	55972	broad.mit.edu	37	7	87471013	87471013	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:87471013G>C	ENST00000341119.5	-	10	1104	c.758C>G	c.(757-759)aCt>aGt	p.T253S		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	253					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					AAATGGTAAAGTTGCAACAGC	0.239000													8	33					0	0	0.010729	0	0
RNF19A	25897	broad.mit.edu	37	8	101271259	101271259	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:101271259T>C	ENST00000519449.1	-	11	2358	c.2042A>G	c.(2041-2043)aAg>aGg	p.K681R	RNF19A_ENST00000341084.2_Missense_Mutation_p.K681R	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	681	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CATGTTACCCTTTTTCCTCAG	0.438000											OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	132					0	0	0.009096	0	0
MAP4K3	8491	broad.mit.edu	37	2	39552700	39552700	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:39552700C>A	ENST00000263881.3	-	12	1201	c.877G>T	c.(877-879)Gat>Tat	p.D293Y	MAP4K3_ENST00000341681.5_Missense_Mutation_p.D293Y|MAP4K3_ENST00000536018.1_5'UTR|MAP4K3_ENST00000437545.1_Missense_Mutation_p.D230Y	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	293					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				GTGGAATGATCTGGATTATTT	0.348000													24	60					2.2171e-23	2.79634e-23	0.041601	1	0
OVCH2	341277	broad.mit.edu	37	11	7718041	7718041	+	RNA	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:7718041G>A	ENST00000454689.1	-	0	1111				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		AGAATACATTGACAGGTAACT	0.453000													20	39					0	0	0.062417	0	0
CSMD2	114784	broad.mit.edu	37	1	34190197	34190197	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:34190197G>A	ENST00000373381.4	-	18	2980	c.2804C>T	c.(2803-2805)tCg>tTg	p.S935L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	895	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGTGTAGCCCGAGTCACAGCT	0.587000													24	65					0	0	0.024334	0	0
FCRL4	83417	broad.mit.edu	37	1	157555986	157555986	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:157555986C>A	ENST00000271532.1	-	6	1242	c.1107G>T	c.(1105-1107)caG>caT	p.Q369H	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	369	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCACCATGCTCTGGACAGGGC	0.498000											OREG0007229	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=FCRL4|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	32	114					6.03168e-27	7.74711e-27	0.074837	1	0
GPR124	25960	broad.mit.edu	37	8	37688280	37688280	+	Silent	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:37688280G>A	ENST00000315215.7	+	7	1134	c.771G>A	c.(769-771)gtG>gtA	p.V257V	GPR124_ENST00000412232.2_Silent_p.V257V			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	257	Ig-like.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TACGCCAAGTGGTGTTCCAGG	0.657000													8	20					0	0	0.047766	0	0
HLA-A	3105	broad.mit.edu	37	6	29910647	29910647	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:29910647G>T	ENST00000396634.1	+	4	528	c.187G>T	c.(187-189)Gac>Tac	p.D63Y	HLA-A_ENST00000376802.2_Missense_Mutation_p.D63Y|HLA-A_ENST00000376809.5_Missense_Mutation_p.D63Y|HLA-A_ENST00000376806.5_Missense_Mutation_p.D63Y			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	63	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						GTTCGACAGCGACGCCGCGAG	0.667000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			11	25					1.52009e-12	1.75588e-12	0.024245	1	0
RBM14	10432	broad.mit.edu	37	11	66392840	66392840	+	Missense_Mutation	SNP	A	A	G	rs144272368		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:66392840A>G	ENST00000310137.4	+	2	1632	c.1493A>G	c.(1492-1494)tAt>tGt	p.Y498C	RBM14_ENST00000409738.4_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000503028.2_Intron|RBM14_ENST00000393979.3_Intron|RBM4_ENST00000514361.3_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	498	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						ACTGGCTCCTATGGTGCCGCA	0.622000													14	46					0	0	0.028581	0	0
TOPBP1	11073	broad.mit.edu	37	3	133362198	133362198	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:133362198G>C	ENST00000260810.5	-	12	1998	c.1867C>G	c.(1867-1869)Cag>Gag	p.Q623E		NM_007027.3	NP_008958.2	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	623	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						AACAAAGTCTGATAGTCTATG	0.373000								Other conserved DNA damage response genes					5	28					0	0	0.014758	0	0
BAZ1A	11177	broad.mit.edu	37	14	35240752	35240752	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:35240752T>A	ENST00000360310.1	-	21	3833	c.3266A>T	c.(3265-3267)cAg>cTg	p.Q1089L	BAZ1A_ENST00000382422.2_Missense_Mutation_p.Q1089L|BAZ1A_ENST00000358716.4_Missense_Mutation_p.Q1057L	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1089					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTCAATGCCCTGCTCTATTTG	0.373000													39	111					0	0	0.048971	0	0
LPHN3	23284	broad.mit.edu	37	4	62679579	62679579	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:62679579C>T	ENST00000512091.1	+	8	1995	c.1248C>T	c.(1246-1248)gaC>gaT	p.D416D	LPHN3_ENST00000504896.1_Silent_p.D416D|LPHN3_ENST00000514996.1_Silent_p.D416D|LPHN3_ENST00000509896.1_Silent_p.D484D|LPHN3_ENST00000508946.1_Silent_p.D416D|LPHN3_ENST00000508693.1_Silent_p.D484D|LPHN3_ENST00000507625.1_Silent_p.D484D|LPHN3_ENST00000506746.1_Silent_p.D484D|LPHN3_ENST00000514591.1_Silent_p.D416D|LPHN3_ENST00000545650.1_Silent_p.D416D|LPHN3_ENST00000514157.1_Silent_p.D416D|LPHN3_ENST00000506700.1_Silent_p.D416D|LPHN3_ENST00000511324.1_Silent_p.D484D|LPHN3_ENST00000506720.1_Silent_p.D484D|LPHN3_ENST00000507164.1_Silent_p.D484D			Q9HAR2	LPHN3_HUMAN	latrophilin 3	416					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ttcaccttgactctgagctag	0.378000													5	46					0	0	0.029380	0	0
OR8B8	26493	broad.mit.edu	37	11	124310488	124310488	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:124310488C>T	ENST00000328064.2	-	1	566	c.494G>A	c.(493-495)gGt>gAt	p.G165D		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GAAGGTCACACCCATCATGCA	0.512000													11	35					0	0	0.069234	0	0
UPK1B	7348	broad.mit.edu	37	3	118909142	118909142	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:118909142C>T	ENST00000264234.3	+	4	470	c.321C>T	c.(319-321)atC>atT	p.I107I	UPK1B_ENST00000497685.1_Silent_p.I27I|UPK1B_ENST00000460625.1_Silent_p.I107I	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	107					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		CATCTTGTATCACAGCAGCAA	0.318000													86	117					0	0	0.048971	0	0
KIF5B	3799	broad.mit.edu	37	10	32329346	32329346	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:32329346C>T	ENST00000302418.4	-	3	711	c.254G>A	c.(253-255)gGa>gAa	p.G85E		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	85	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				GGATGTTTGTCCATATGCAAA	0.323000			T	"""RET, ALK"""	NSCLC								10	54					0	0	0.069234	0	0
FBXO39	162517	broad.mit.edu	37	17	6683381	6683381	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:6683381G>T	ENST00000321535.4	+	2	324	c.194G>T	c.(193-195)gGg>gTg	p.G65V		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	65										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						ACCTTCAGCGGGAGACCTTCC	0.498000													42	35					1.32136e-16	1.59199e-16	0.033182	1	0
C1orf177	163747	broad.mit.edu	37	1	55307302	55307302	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:55307302T>C	ENST00000358193.3	+	10	1252	c.1198T>C	c.(1198-1200)Tgt>Cgt	p.C400R	C1orf177_ENST00000371273.3_Intron	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	0										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CAGGCTGTTTTgttggaaagg	0.433000													33	66					0	0	0.027894	0	0
CCDC86	79080	broad.mit.edu	37	11	60610191	60610191	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:60610191A>G	ENST00000227520.5	+	1	648	c.594A>G	c.(592-594)ccA>ccG	p.P198P	RP11-804A23.2_ENST00000539897.1_RNA|RP11-804A23.4_ENST00000538705.1_RNA	NM_024098.3	NP_077003.1	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	198	Pro-rich.				interspecies interaction between organisms	nucleus				endometrium(1)|large_intestine(2)|liver(2)|lung(2)|urinary_tract(3)	10						CGAGCAAGCCACCTCCAGCTG	0.637000													3	15					0	0	0.014758	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													7	127					0	0	0.038147	0	0
FRG1B	284802	broad.mit.edu	37	20	29632695	29632695	+	Silent	SNP	A	A	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr20:29632695A>T	ENST00000278882.3	+	8	890	c.510A>T	c.(508-510)ggA>ggT	p.G170G	FRG1B_ENST00000358464.4_Silent_p.G170G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAAGATGGATTTTTGCATG	0.318000													20	509					0	0	0.062417	0	0
PLVAP	83483	broad.mit.edu	37	19	17488060	17488060	+	Missense_Mutation	SNP	C	C	G	rs145946398		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr19:17488060C>G	ENST00000252590.4	-	1	99	c.38G>C	c.(37-39)cGg>cCg	p.R13P		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	13						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCCCCCCGCCCGAGCGTAGGA	0.652000													37	110					0	0	0.045515	0	0
MGAT5	4249	broad.mit.edu	37	2	135076221	135076221	+	Splice_Site	SNP	T	T	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr2:135076221T>A	ENST00000409645.1	+	5	736	c.483_splice	c.e5-1	p.W162_splice	MGAT5_ENST00000281923.2_Splice_Site_p.W162_splice			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	162					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CTTGTTTCAGTGGATGAAAGA	0.488000													48	131					0	0	0.048971	0	0
STC2	8614	broad.mit.edu	37	5	172745196	172745196	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:172745196G>A	ENST00000265087.4	-	4	1872	c.563C>T	c.(562-564)gCc>gTc	p.A188V	STC2_ENST00000520593.1_5'UTR	NM_003714.2	NP_003705.1	O76061	STC2_HUMAN	stanniocalcin 2	188					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(3)	25	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GTGGGTGATGGCCTCCTTCAC	0.567000													10	27					0	0	0.013537	0	0
AGTR2	186	broad.mit.edu	37	X	115304135	115304135	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:115304135C>T	ENST00000371906.4	+	3	792	c.602C>T	c.(601-603)cCt>cTt	p.P201L		NM_000686.4	NP_000677.2	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	201					behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|skin(1)	24						GCTTTCCCACCTGAGAAATAT	0.378000													30	23					0	0	0.064281	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237907	33237907	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:33237907C>G	ENST00000401073.2	+	6	3197	c.3127C>G	c.(3127-3129)Cga>Gga	p.R1043G	KIAA1522_ENST00000373481.3_Missense_Mutation_p.R995G|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373480.1_Missense_Mutation_p.R984G	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	984										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CAGTTACCCTCGAGCTGAGCC	0.662000													20	77					0	0	0.076483	0	0
CCDC39	339829	broad.mit.edu	37	3	180334372	180334372	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:180334372C>T	ENST00000442201.2	-	18	2637	c.2518G>A	c.(2518-2520)Gaa>Aaa	p.E840K	TTC14_ENST00000382584.4_Intron|CCDC39_ENST00000273654.4_3'UTR	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	840					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ACTAACATTTCATCAATAACT	0.308000													14	11					0	0	0.028581	0	0
KMT2C	58508	broad.mit.edu	37	7	151932917	151932917	+	Silent	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:151932917A>G	ENST00000355193.2	-	16	2972	c.2754T>C	c.(2752-2754)gcT>gcC	p.A918A	KMT2C_ENST00000262189.6_Silent_p.A918A					lysine (K)-specific methyltransferase 2C																		GTAATACAACAGCTCCGATTC	0.468000													31	218					0	0	0.036044	0	0
ST14	6768	broad.mit.edu	37	11	130064080	130064080	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:130064080C>T	ENST00000278742.5	+	8	1330	c.912C>T	c.(910-912)acC>acT	p.T304T		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	304	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	ACAACCTGACCTTCCACTCCT	0.577000													78	159					0	0	0.048971	0	0
VEZF1	7716	broad.mit.edu	37	17	56060700	56060700	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:56060700G>C	ENST00000584396.1	-	2	149	c.61C>G	c.(61-63)Ctc>Gtc	p.L21V	VEZF1_ENST00000581208.1_Missense_Mutation_p.L30V			Q14119	VEZF1_HUMAN	vascular endothelial zinc finger 1	30					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						GAGCTCAGGAGGGGCAGCAAG	0.498000													26	99					0	0	0.034045	0	0
KIAA0195	9772	broad.mit.edu	37	17	73492070	73492070	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:73492070A>G	ENST00000314256.7	+	23	3362	c.2968A>G	c.(2968-2970)Atg>Gtg	p.M990V	KIAA0195_ENST00000579208.1_Missense_Mutation_p.M641V|KIAA0195_ENST00000375248.5_Missense_Mutation_p.M1000V	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	990					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GATAAAGATCATGCAAGAGTA	0.602000													33	19					0	0	0.080422	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40844610	40844610	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:40844610G>A	ENST00000264638.4	+	17	2841	c.2624G>A	c.(2623-2625)tGg>tAg	p.W875*	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	875	Laminin G-like 3.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GATGACGAGTGGCACCTGGTC	0.577000													100	63					0	0	0.048971	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197311	26197311	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:26197311C>T	ENST00000377831.5	-	2	621	c.168G>A	c.(166-168)caG>caA	p.Q56Q	HIST1H3D_ENST00000356476.2_Silent_p.Q56Q	NM_003530.3	NP_003521.2	P68431	H31_HUMAN	histone cluster 1, H3d	56					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)	14		all_hematologic(11;0.196)				CGGTCGACTTCTGGTAGCGGC	0.632000													16	79					0	0	0.021523	0	0
LRRCC1	85444	broad.mit.edu	37	8	86039068	86039068	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:86039068G>A	ENST00000414626.2	+	8	2246	c.1357G>A	c.(1357-1359)Gat>Aat	p.D453N	LRRCC1_ENST00000360375.3_Missense_Mutation_p.D473N			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	473					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						ACTTACCACAGATAGGTAAAA	0.338000													20	44					0	0	0.055883	0	0
NDRG2	57447	broad.mit.edu	37	14	21490336	21490336	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:21490336A>C	ENST00000556147.1	-	5	1169	c.229T>G	c.(229-231)Tct>Gct	p.S77A	NDRG2_ENST00000555158.1_Missense_Mutation_p.S63A|NDRG2_ENST00000554143.1_Missense_Mutation_p.S63A|NDRG2_ENST00000298684.5_Missense_Mutation_p.S63A|NDRG2_ENST00000298687.5_Missense_Mutation_p.S77A|NDRG2_ENST00000397853.3_Missense_Mutation_p.S77A|NDRG2_ENST00000553503.1_Missense_Mutation_p.S63A|NDRG2_ENST00000554104.1_5'UTR|NDRG2_ENST00000350792.3_Missense_Mutation_p.S63A|NDRG2_ENST00000397858.1_Missense_Mutation_p.S77A|NDRG2_ENST00000397844.2_Missense_Mutation_p.S63A|NDRG2_ENST00000360463.3_Missense_Mutation_p.S63A|NDRG2_ENST00000397847.2_Missense_Mutation_p.S77A|NDRG2_ENST00000397851.2_Missense_Mutation_p.S77A|NDRG2_ENST00000397855.3_Missense_Mutation_p.S63A|NDRG2_ENST00000397856.3_Missense_Mutation_p.S63A|NDRG2_ENST00000403829.3_Missense_Mutation_p.S73A			Q9UN36	NDRG2_HUMAN	NDRG family member 2	77					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	23	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TGGAAGCAAGATTTATCTAAA	0.502000													23	42					0	0	0.027356	0	0
THRA	7067	broad.mit.edu	37	17	38240976	38240976	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr17:38240976C>G	ENST00000450525.2	+	6	975	c.484C>G	c.(484-486)Cct>Gct	p.P162A	THRA_ENST00000546243.1_Missense_Mutation_p.P162A|THRA_ENST00000394121.4_Missense_Mutation_p.P162A|THRA_ENST00000584985.1_Missense_Mutation_p.P162A|THRA_ENST00000264637.4_Missense_Mutation_p.P162A	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	162					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	AGAGCCCACTCCTGAAGAGTG	0.597000													53	122					0	0	0.048971	0	0
CATSPER1	117144	broad.mit.edu	37	11	65788969	65788969	+	Silent	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr11:65788969G>C	ENST00000312106.5	-	4	1826	c.1689C>G	c.(1687-1689)ctC>ctG	p.L563L		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	563					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCACTGACCTGAGCCTCCGCA	0.617000													14	34					0	0	0.033300	0	0
MYH15	22989	broad.mit.edu	37	3	108129526	108129526	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:108129526G>C	ENST00000273353.3	-	32	4515	c.4459C>G	c.(4459-4461)Cag>Gag	p.Q1487E		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1487						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTGAGAGCCTGAACTTCCTTC	0.572000													14	74					0	0	0.028581	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617343	77617343	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:77617343A>C	ENST00000521891.2	+	2	1468	c.1020A>C	c.(1018-1020)aaA>aaC	p.K340N	ZFHX4_ENST00000518282.1_Missense_Mutation_p.K340N|ZFHX4_ENST00000455469.2_Missense_Mutation_p.K340N|ZFHX4_ENST00000050961.6_Missense_Mutation_p.K340N|ZFHX4_ENST00000517683.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	340						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.K340N(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACCAAAAAAATCCACTTCTG	0.433000										HNSCC(33;0.089)			23	57					0	0	0.021523	0	0
SOGA2	23255	broad.mit.edu	37	18	8819032	8819032	+	Silent	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr18:8819032C>T	ENST00000359865.3	+	13	3073	c.2931C>T	c.(2929-2931)ccC>ccT	p.P977P	SOGA2_ENST00000518815.1_Intron|SOGA2_ENST00000306285.7_Intron|SOGA2_ENST00000306329.11_Silent_p.P1296P|SOGA2_ENST00000400050.3_Silent_p.P936P|SOGA2_ENST00000517570.1_Silent_p.P936P	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1287																	ACGTTCGCCCCTTTCCCCACC	0.527000													45	101					0	0	0.048971	0	0
KIAA1549	57670	broad.mit.edu	37	7	138579146	138579146	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr7:138579146C>A	ENST00000440172.1	-	10	4022	c.3974G>T	c.(3973-3975)cGc>cTc	p.R1325L	KIAA1549_ENST00000422774.1_Missense_Mutation_p.R1325L|KIAA1549_ENST00000242365.4_Missense_Mutation_p.R1275L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1325						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CTTGTCTGTGCGGCATAGTTT	0.522000			O	BRAF	pilocytic astrocytoma								47	166					3.10996e-30	4.06152e-30	0.048971	1	0
KIAA0586	9786	broad.mit.edu	37	14	58954712	58954712	+	Missense_Mutation	SNP	A	A	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr14:58954712A>G	ENST00000423743.3	+	24	3538	c.3280A>G	c.(3280-3282)Att>Gtt	p.I1094V	KIAA0586_ENST00000354386.6_Missense_Mutation_p.I1191V|KIAA0586_ENST00000261244.5_Missense_Mutation_p.I1062V|KIAA0586_ENST00000556134.1_Missense_Mutation_p.I1123V|KIAA0586_ENST00000538571.2_3'UTR	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1062										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGATATTTCCATTGATAAATT	0.473000													6	21					0	0	0.029380	0	0
GLS2	27165	broad.mit.edu	37	12	56872853	56872853	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr12:56872853C>T	ENST00000311966.4	-	4	795	c.517G>A	c.(517-519)Gag>Aag	p.E173K	GLS2_ENST00000539272.1_Intron	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	173					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAGTGAGCTCTTTGACATCC	0.473000													50	97					0	0	0.048971	0	0
TMCO2	127391	broad.mit.edu	37	1	40713748	40713749	+	Frame_Shift_Ins	INS	-	-	T			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:40713748_40713749insT	ENST00000372766.3	+	1	176_177	c.83_84insT	c.(82-84)attfs	p.I28fs	TMCO2_ENST00000468258.1_Intron	NM_001008740.3	NP_001008740.1	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	28						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			ATACAAGCAAGTTTTTTGGGAG	0.406													66	221	---	---	---	---					
ASPM	259266	broad.mit.edu	37	1	197057405	197057405	+	Frame_Shift_Del	DEL	T	T	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr1:197057405delT	ENST00000367409.4	-	26	10398	c.10142delA	c.(10141-10143)agfs	p.K3381fs	ASPM_ENST00000294732.7_Frame_Shift_Del_p.K1796fs|ASPM_ENST00000367408.1_Frame_Shift_Del_p.K1046fs	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3381					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ATTTGTTGTCTTCAGTAAAAT	0.338													94	79	---	---	---	---					
IGSF11	152404	broad.mit.edu	37	3	118623578	118623579	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr3:118623578_118623579insA	ENST00000354673.2	-	8	1147_1148	c.767_768insT	c.(766-768)tatfs	p.Y256fs	IGSF11_ENST00000491903.1_Intron|IGSF11_ENST00000393775.2_Frame_Shift_Ins_p.Y257fs|IGSF11_ENST00000489689.1_Frame_Shift_Ins_p.Y233fs|IGSF11_ENST00000441144.2_Frame_Shift_Ins_p.Y232fs|IGSF11_ENST00000425327.2_Frame_Shift_Ins_p.Y256fs	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	257					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity	p.C256fs*17(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TTAGTGCAATGCAAAAAATGAT	0.342													131	177	---	---	---	---					
BEND4	389206	broad.mit.edu	37	4	42122225	42122225	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:42122225delC	ENST00000502486.1	-	5	1812	c.1233delG	c.(1231-1233)ggfs	p.G411fs	BEND4_ENST00000504360.1_Frame_Shift_Del_p.G407fs	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	411	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						GGAGCCGTCTCCCATCTTTCT	0.458													25	41	---	---	---	---					
LPHN3	23284	broad.mit.edu	37	4	62897312	62897312	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr4:62897312delG	ENST00000512091.1	+	22	4118	c.3371delG	c.(3370-3372)ttfs	p.C1124fs	LPHN3_ENST00000504896.1_Frame_Shift_Del_p.C1124fs|LPHN3_ENST00000514157.1_Frame_Shift_Del_p.C1115fs|LPHN3_ENST00000509896.1_Frame_Shift_Del_p.C1192fs|LPHN3_ENST00000508946.1_Frame_Shift_Del_p.C1124fs|LPHN3_ENST00000514996.1_Frame_Shift_Del_p.C1115fs|LPHN3_ENST00000545650.1_Frame_Shift_Del_p.C1124fs|LPHN3_ENST00000507164.1_Frame_Shift_Del_p.C1183fs|LPHN3_ENST00000507625.1_Frame_Shift_Del_p.C1183fs|LPHN3_ENST00000506746.1_Frame_Shift_Del_p.C1183fs|LPHN3_ENST00000511324.1_Frame_Shift_Del_p.C1183fs|LPHN3_ENST00000514591.1_Frame_Shift_Del_p.C1124fs|LPHN3_ENST00000508693.1_Frame_Shift_Del_p.C1192fs|LPHN3_ENST00000506700.1_Frame_Shift_Del_p.C1115fs|LPHN3_ENST00000506720.1_Frame_Shift_Del_p.C1192fs			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1102					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ATTTTCCATTGTGTCCTACAG	0.313													19	36	---	---	---	---					
SPRY4	81848	broad.mit.edu	37	5	141694361	141694363	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:141694361_141694363delTGC	ENST00000344120.4	-	3	566_568	c.380_382delGCA	c.(379-384)aca>a	p.ST127del	SPRY4_ENST00000434127.2_In_Frame_Del_p.ST104del	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	104					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGAGGATGTGCTGCTGCTGCT	0.660									Testicular Cancer, Familial Clustering of				7	190	---	---	---	---					
CCNJL	79616	broad.mit.edu	37	5	159686536	159686536	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr5:159686536delG	ENST00000393977.3	-	5	952	c.667delC	c.(667-669)gcfs	p.R223fs	CCNJL_ENST00000519673.1_Frame_Shift_Del_p.R175fs|CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000257536.7_Frame_Shift_Del_p.R175fs|CCNJL_ENST00000541762.1_Frame_Shift_Del_p.R174fs	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	223						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGGTCTTGCGGGGGCAGGTG	0.627													26	129	---	---	---	---					
ARID1B	57492	broad.mit.edu	37	6	157099403	157099405	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr6:157099403_157099405delCAG	ENST00000346085.5	+	1	341_343	c.340_342delCAG	c.(340-342)del	p.Q131del	ARID1B_ENST00000367148.1_In_Frame_Del_p.Q131del|ARID1B_ENST00000350026.5_In_Frame_Del_p.Q131del|ARID1B_ENST00000275248.4_In_Frame_Del_p.Q73del	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	131	Gln-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AAACCAGTTCcagcagcagcagc	0.640													3	5	---	---	---	---					
DCAF4L2	138009	broad.mit.edu	37	8	88885347	88885347	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr8:88885347delG	ENST00000319675.3	-	1	949	c.853delC	c.(853-855)tgfs	p.L285fs		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	285										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GATGACACCAGGAATTGGCCA	0.498													29	52	---	---	---	---					
CUEDC2	79004	broad.mit.edu	37	10	104184914	104184915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr10:104184914_104184915insG	ENST00000369937.4	-	2	176_177	c.31_32insC	c.(31-33)cctfs	p.P11fs		NM_024040.2	NP_076945.2	Q9H467	CUED2_HUMAN	CUE domain containing 2	11						cytoplasm|nucleus	protein binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		AAAGGCAAGGAGGGCTGCACTG	0.639													33	77	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48934258	48934259	+	Frame_Shift_Ins	INS	-	-	A			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr13:48934258_48934259insA	ENST00000267163.4	+	7	851_852	c.713_714insA	c.(712-714)ctafs	p.L238fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	238					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCAAAGAACCATATAGTAAGT	0.356		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			19	30	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000560219.1_Intron|MESP2_ENST00000558723.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													5	4	---	---	---	---					
CERS3	204219	broad.mit.edu	37	15	101031128	101031129	+	Frame_Shift_Ins	INS	-	-	C			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr15:101031128_101031129insC	ENST00000284382.4	-	5	604_605	c.181_182insG	c.(181-183)ttcfs	p.F61fs	CERS3_ENST00000394113.1_Frame_Shift_Ins_p.F61fs|CERS3_ENST00000538112.2_Frame_Shift_Ins_p.F61fs|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	61						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TAGAGGTGAAGCAACAAATCTA	0.322													22	41	---	---	---	---					
CCT8L2	150160	broad.mit.edu	37	22	17072854	17072854	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chr22:17072854delC	ENST00000359963.3	-	1	846	c.587delG	c.(586-588)gcfs	p.G196fs		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	196					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTTGAAGCTGCCGTCTAGTTC	0.612													118	42	---	---	---	---					
MED12	9968	broad.mit.edu	37	X	70339996	70339997	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-95-7947-01A-11D-2184-08	TCGA-95-7947-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a9ed047-e91a-46e2-a054-82f000bc35ea	81a2d022-e55f-49c7-856c-9258fd01c9e5	g.chrX:70339996_70339997insAG	ENST00000333646.6	+	4	728_729	c.529_530insAG	c.(529-531)gagfs	p.E177fs	MED12_ENST00000374102.1_Frame_Shift_Ins_p.E177fs|MED12_ENST00000374080.3_Frame_Shift_Ins_p.E177fs	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	177					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CAAGGTTAAGAAGAGACATGTT	0.490			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						61	38	---	---	---	---					
