Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HIST1H3B	8358	broad.mit.edu	37	6	26032138	26032138	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:26032138C>G	ENST00000244661.2	-	1	150	c.151G>C	c.(151-153)Gag>Cag	p.E51Q		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.E51Q(1)		breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CGGCGGATCTCGCGCAGAGCC	0.627000													19	134					0	0	1	0	0
ALOX15B	247	broad.mit.edu	37	17	7950584	7950584	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:7950584C>G	ENST00000380183.4	+	11	1605	c.1466C>G	c.(1465-1467)tCt>tGt	p.S489C	ALOX15B_ENST00000380173.2_Missense_Mutation_p.S460C|ALOX15B_ENST00000573359.1_Intron|ALOX15B_ENST00000572022.1_Intron	NM_001141.2	NP_001132.2	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, type B	489	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	24						AGCTTTGTCTCTGAAATCATC	0.532000													76	68					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890191	55890191	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:55890191C>G	ENST00000313472.3	+	1	343	c.343C>G	c.(343-345)Ctc>Gtc	p.L115V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					ATGTTATCTTCTCTCCTCAAT	0.473000													47	231					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110113848	110113848	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:110113848G>A	ENST00000230124.3	+	21	2564	c.2440G>A	c.(2440-2442)Gat>Aat	p.D814N	FIG4_ENST00000441478.2_Missense_Mutation_p.D537N	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	814					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTCAGAAGAAGATTTCTCCAT	0.313000													15	27					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65850861	65850861	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:65850861G>A	ENST00000321892.4	+	2	1480	c.1419G>A	c.(1417-1419)ttG>ttA	p.L473L	BPTF_ENST00000424123.3_Silent_p.L334L|BPTF_ENST00000306378.6_Silent_p.L473L|BPTF_ENST00000335221.5_Silent_p.L473L			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	473					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACTGGTTCTTGAACCGAAGAC	0.353000													8	47					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30065669	30065669	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:30065669G>C	ENST00000201979.2	+	3	672	c.379G>C	c.(379-381)Gac>Cac	p.D127H		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	127					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGATGGAGAAGACACCACACT	0.557000													9	27					0	0	1	0	0
SSMEM1	136263	broad.mit.edu	37	7	129847761	129847761	+	Missense_Mutation	SNP	T	T	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:129847761T>C	ENST00000297819.3	+	1	62	c.11T>C	c.(10-12)cTt>cCt	p.L4P		NM_145268.3	NP_660311.1			serine-rich single-pass membrane protein 1																		ATGGGAGACCTTTTTTCCTTA	0.413000													3	107					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049273	36049273	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:36049273G>A	ENST00000282507.3	-	4	662	c.561C>T	c.(559-561)ttC>ttT	p.F187F	UGT3A2_ENST00000504954.1_Intron|UGT3A2_ENST00000545528.1_Intron|UGT3A2_ENST00000513300.1_Silent_p.F153F	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	187						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCAAGGAACGGAATACTGGAA	0.463000													25	71					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94029590	94029590	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:94029590G>A	ENST00000297268.6	+	5	686	c.215G>A	c.(214-216)gGt>gAt	p.G72D		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	72					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGCCCCCCTGGTCTCGGTGGG	0.488000										HNSCC(75;0.22)			4	85					0	0	1	0	0
NPRL2	10641	broad.mit.edu	37	3	50386409	50386409	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:50386409C>G	ENST00000232501.3	-	5	919	c.481G>C	c.(481-483)Gag>Cag	p.E161Q		NM_006545.4	NP_006536.3	Q8WTW4	NPRL2_HUMAN	nitrogen permease regulator-like 2 (S. cerevisiae)	161					negative regulation of kinase activity		protein binding|protein kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	11						GGCCGCTGCTCAATCACCTTC	0.532000													49	65					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510847	56510847	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:56510847A>G	ENST00000302957.3	-	1	440	c.441T>C	c.(439-441)taT>taC	p.Y147Y		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TGGTACCTGAATAAAGCAATG	0.488000													7	158					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073363	134073363	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:134073363G>A	ENST00000264360.4	+	1	2894	c.2068G>A	c.(2068-2070)Ggg>Agg	p.G690R		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	690	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		gggcgggggcgggagcggagg	0.706000													22	35					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104897032	104897032	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:104897032C>T	ENST00000533400.1	-	9	1203	c.1168G>A	c.(1168-1170)Gaa>Aaa	p.E390K	CASP1_ENST00000526568.1_Missense_Mutation_p.E297K|CASP1_ENST00000525825.1_Missense_Mutation_p.E369K|CASP1_ENST00000598974.1_Missense_Mutation_p.E390K|CASP1_ENST00000534497.1_Missense_Mutation_p.E249K|CASP1_ENST00000436863.3_Missense_Mutation_p.E390K|CASP1_ENST00000531166.1_Missense_Mutation_p.E74K|CASP1_ENST00000446369.1_Missense_Mutation_p.E249K|CASP1_ENST00000415981.2_Missense_Mutation_p.E74K|CASP1_ENST00000393136.4_Missense_Mutation_p.E369K|CASP1_ENST00000353247.5_Missense_Mutation_p.E74K|CASP1_ENST00000594519.1_Missense_Mutation_p.E249K|CASP1_ENST00000527979.1_Missense_Mutation_p.E353K|CASP1_ENST00000593315.1_Missense_Mutation_p.E369K	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	390					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	GTCACTCTTTCAGTGGTGGGC	0.423000													12	75					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56346586	56346586	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:56346586C>A	ENST00000331886.5	+	21	2266	c.1812C>A	c.(1810-1812)agC>agA	p.S604R	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Missense_Mutation_p.S604R|DGKA_ENST00000551156.1_Missense_Mutation_p.S604R	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	604					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	ACATCCCTAGCATGCATGGTG	0.552000													99	84					1.73998e-50	1.89485e-50	1	1	0
KLRAP1	10748	broad.mit.edu	37	12	10750794	10750794	+	RNA	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:10750794G>A	ENST00000510134.2	-	0	162																				breast(1)|large_intestine(1)|lung(1)	3						TTCAAATCCTGAAATAGGATG	0.383000													5	9					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72017964	72017964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:72017964G>A	ENST00000378743.3	-	23	4784	c.4426C>T	c.(4426-4428)Cag>Tag	p.Q1476*		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1476					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TCTAAAAGCTGAAAGGACAAA	0.408000													13	161					0	0	1	0	0
UBOX5	22888	broad.mit.edu	37	20	3102754	3102754	+	Silent	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:3102754G>T	ENST00000217173.2	-	3	1002	c.531C>A	c.(529-531)atC>atA	p.I177I	UBOX5_ENST00000348031.2_Silent_p.I177I|UBOX5-AS1_ENST00000446537.1_RNA	NM_001267584.1|NM_014948.3	NP_001254513.1|NP_055763.1	O94941	RNF37_HUMAN	U-box domain containing 5	177						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	20						TCACATGGGTGATACAGATCC	0.582000													22	76					9.86323e-18	1.06298e-17	1	1	0
SERINC5	256987	broad.mit.edu	37	5	79454754	79454754	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:79454754G>C	ENST00000507668.2	-	8	1041	c.891C>G	c.(889-891)atC>atG	p.I297M	SERINC5_ENST00000509193.1_Missense_Mutation_p.I295M|SERINC5_ENST00000512972.2_Missense_Mutation_p.I297M|SERINC5_ENST00000512721.1_Missense_Mutation_p.I297M	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	297					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		CAGGCACACAGATTGTAACAT	0.403000													5	95					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29041325	29041325	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:29041325G>A	ENST00000257189.4	+	8	1032	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	317	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAATTGGTTTGAAATACAAAC	0.348000													21	76					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38690475	38690475	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:38690475C>T	ENST00000396832.1	-	8	1211	c.951G>A	c.(949-951)atG>atA	p.M317I	CSNK1E_ENST00000403904.1_Missense_Mutation_p.M317I|CSNK1E_ENST00000400206.2_Missense_Mutation_p.M317I|CSNK1E_ENST00000359867.3_Missense_Mutation_p.M317I	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	317					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					GTAGCTGCCCCATCCTCTCCT	0.706000													3	18					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35444128	35444128	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:35444128C>T	ENST00000338863.7	-	9	904	c.677G>A	c.(676-678)cGg>cAg	p.R226Q	TEAD3_ENST00000402886.3_Missense_Mutation_p.R166Q	NM_003214.3	NP_003205.2	Q99594	TEAD3_HUMAN	TEA domain family member 3	226	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						CTCCAGGAGCCGCAGCCGGGA	0.632000													17	49					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69832647	69832647	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:69832647C>G	ENST00000395198.3	-	3	466	c.219G>C	c.(217-219)aaG>aaC	p.K73N	HERC4_ENST00000373700.4_Missense_Mutation_p.K73N|HERC4_ENST00000412272.2_Missense_Mutation_p.K73N|HERC4_ENST00000395187.2_Missense_Mutation_p.K73N|HERC4_ENST00000492996.1_Missense_Mutation_p.K73N	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	73					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						TACCTGGTTTCTTTCTGGATT	0.308000													4	81					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565946	18565946	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:18565946C>G	ENST00000545289.1	-	5	1123	c.873G>C	c.(871-873)caG>caC	p.Q291H		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						TATGAGTTCTCTGGTGTTTAG	0.403000													9	48					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31309257	31309257	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:31309257C>G	ENST00000544665.3	+	14	1763	c.1692C>G	c.(1690-1692)atC>atG	p.I564M	ITGAM_ENST00000287497.8_Missense_Mutation_p.I563M	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	563					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GATCTGGCATCAGCCCCTCCC	0.557000													10	39					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48719862	48719862	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:48719862C>T	ENST00000314191.2	-	70	9636	c.9580G>A	c.(9580-9582)Gag>Aag	p.E3194K	PRKDC_ENST00000338368.3_Missense_Mutation_p.E3194K|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3195	FAT.|KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GTAAGCTTCTCCTCTATTTTG	0.418000								Non-homologous end-joining					53	97					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74173158	74173158	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:74173158C>A	ENST00000324896.4	+	34	3376	c.2987C>A	c.(2986-2988)cCc>cAc	p.P996H	GTF2I_ENST00000416070.1_Missense_Mutation_p.P955H|GTF2I_ENST00000346152.4_Missense_Mutation_p.P975H|GTF2I_ENST00000353920.4_Missense_Mutation_p.P976H	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	996					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						GAACCAGACCCCACGTGGTAG	0.468000													3	75					7.48243e-07	7.78173e-07	1	1	0
IER3IP1	51124	broad.mit.edu	37	18	44683867	44683867	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:44683867C>A	ENST00000256433.3	-	2	229	c.133G>T	c.(133-135)Gag>Tag	p.E45*	IER3IP1_ENST00000588705.1_Nonsense_Mutation_p.E45*	NM_016097.4	NP_057181.1	Q9Y5U9	IR3IP_HUMAN	immediate early response 3 interacting protein 1	45						endoplasmic reticulum membrane|Golgi apparatus|integral to membrane				large_intestine(1)	1						ATTCCCGGCTCTTCTCCAAAT	0.393000													32	112					1.4659e-37	1.58806e-37	1	1	0
TBC1D22A	25771	broad.mit.edu	37	22	47290698	47290698	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:47290698C>T	ENST00000337137.4	+	7	1022	c.856C>T	c.(856-858)Cgc>Tgc	p.R286C	TBC1D22A_ENST00000407381.3_Missense_Mutation_p.R227C|TBC1D22A_ENST00000406733.1_Missense_Mutation_p.R239C|TBC1D22A_ENST00000380995.1_Missense_Mutation_p.R239C|TBC1D22A_ENST00000355704.3_Missense_Mutation_p.R208C	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	286	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		AGACATCCCTCGCATGAGCCC	0.507000													35	110					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126238505	126238505	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:126238505C>G	ENST00000394329.3	+	1	952	c.939C>G	c.(937-939)ttC>ttG	p.F313L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	313	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCCTGGACTTCGAAGCTCGGC	0.647000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	45					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40251560	40251560	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:40251560G>C	ENST00000302541.6	+	11	2223	c.1881G>C	c.(1879-1881)caG>caC	p.Q627H	MYRIP_ENST00000396217.3_Missense_Mutation_p.Q538H|MYRIP_ENST00000444716.1_Missense_Mutation_p.Q627H|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000425621.1_Missense_Mutation_p.Q627H|MYRIP_ENST00000539167.1_Missense_Mutation_p.Q440H	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	627	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACAACAGCCAGAGTGTCCAGG	0.507000													17	14					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:178936091G>A	ENST00000263967.3	+	10	1790	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	545	PI3K helical.		E -> A (in cancer).|E -> G (in KERSEB).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(881)|p.E545Q(18)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(BC3C_URINARY_TRACT)|E545K(BFTC909_KIDNEY)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(HCC202_BREAST)|E545K(HCT15_LARGE_INTESTINE)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(KYSE510_OESOPHAGUS)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(MCF7_BREAST)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(NCIH460_LUNG)|E545K(NCIH508_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(RERFLCSQ1_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			24	29					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562493	75562493	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:75562493C>A	ENST00000300576.5	+	18	2035	c.2035C>A	c.(2035-2037)Ccg>Acg	p.P679T		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	679										ovary(1)	1						TGACAACCCCCCGGTACAGCA	0.602000													4	71					1	1	1	1	0
KBTBD6	89890	broad.mit.edu	37	13	41704658	41704658	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr13:41704658C>G	ENST00000379485.1	-	1	2224	c.1990G>C	c.(1990-1992)Gat>Cat	p.D664H	KBTBD6_ENST00000499385.2_Missense_Mutation_p.D598H	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	664							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AAATCATCATCAGAAAGAGAA	0.418000													14	22					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2409156	2409156	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:2409156G>A	ENST00000360876.4	+	10	1509	c.1453G>A	c.(1453-1455)Gaa>Aaa	p.E485K	EIF3B_ENST00000397011.2_Missense_Mutation_p.E485K	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	485					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTGGGTGCCTGAAGACAAAGA	0.473000													40	181					0	0	1	0	0
GNB5	10681	broad.mit.edu	37	15	52433340	52433340	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:52433340C>T	ENST00000261837.7	-	7	689	c.624G>A	c.(622-624)atG>atA	p.M208I	GNB5_ENST00000358784.7_Missense_Mutation_p.M166I|GNB5_ENST00000396335.4_Intron	NM_016194.3	NP_057278.2	O14775	GBB5_HUMAN	guanine nucleotide binding protein (G protein), beta 5	208						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			large_intestine(1)|lung(1)	2				all cancers(107;0.0163)		TATTTACCTGCATGTCAGAGT	0.507000													15	64					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39579083	39579083	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:39579083G>A	ENST00000225550.3	-	3	678	c.679C>T	c.(679-681)Cag>Tag	p.Q227*	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	227	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				GACTCCTGCTGGGCCTCCAGG	0.667000													12	36					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20508167	20508167	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:20508167C>G	ENST00000361078.2	-	5	719	c.697G>C	c.(697-699)Gaa>Caa	p.E233Q	PUM2_ENST00000319801.5_Missense_Mutation_p.E233Q|PUM2_ENST00000338086.5_Missense_Mutation_p.E233Q|PUM2_ENST00000536417.1_Missense_Mutation_p.E177Q|PUM2_ENST00000403432.1_Missense_Mutation_p.E233Q			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	233	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTAAGGATTCCAGACCAACT	0.433000													23	102					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77618802	77618802	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:77618802G>C	ENST00000534064.1	-	16	2011	c.1977C>G	c.(1975-1977)ttC>ttG	p.F659L	AAMDC_ENST00000532481.1_Intron|INTS4_ENST00000535943.1_Missense_Mutation_p.F34L	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	659					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AGGTGGCAGAGAAATCAGCTA	0.408000													4	125					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448792	89448792	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:89448792C>T	ENST00000399794.2	-	3	1433	c.718G>A	c.(718-720)Gat>Aat	p.D240N	RBMXL1_ENST00000321792.5_Missense_Mutation_p.D240N|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000260508.4_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	240							nucleotide binding|RNA binding										TAAGTATAATCTCGTGGTGGT	0.428000													32	33					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131676071	131676071	+	Missense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:131676071C>A	ENST00000368648.3	-	7	669	c.597G>T	c.(595-597)ttG>ttT	p.L199F	EBF3_ENST00000355311.5_Missense_Mutation_p.L199F	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	199	Interaction with DNA (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CTGCATTCTTCAAACAGTTCT	0.358000													15	34					3.99206e-14	4.28014e-14	1	1	0
CNTD1	124817	broad.mit.edu	37	17	40957872	40957872	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:40957872G>T	ENST00000588408.1	+	4	826	c.550G>T	c.(550-552)Gca>Tca	p.A184S	CNTD1_ENST00000315066.5_3'UTR|CNTD1_ENST00000588527.1_Missense_Mutation_p.A101S	NM_173478.2	NP_775749.2	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	184										central_nervous_system(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CACTCCCCTGGCATATGTGGA	0.458000													13	42					3.52763e-06	3.65048e-06	1	1	0
PCMTD1	115294	broad.mit.edu	37	8	52733136	52733136	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:52733136C>G	ENST00000360540.5	-	7	1255	c.849G>C	c.(847-849)caG>caC	p.Q283H	PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000544451.1_Missense_Mutation_p.Q207H|PCMTD1_ENST00000522514.1_Missense_Mutation_p.Q283H	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	283						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				TGTTAATTCTCTGTTTAACTC	0.408000													6	261					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27448608	27448608	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:27448608G>A	ENST00000375946.4	+	3	988	c.385G>A	c.(385-387)Gat>Aat	p.D129N	MASTL_ENST00000375940.4_Missense_Mutation_p.D129N|MASTL_ENST00000342386.6_Missense_Mutation_p.D129N	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	129	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGTTATTTTGATGAAGAGAT	0.338000													25	74					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562495	75562495	+	Silent	SNP	G	G	T	rs138154232	by1000genomes	TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:75562495G>T	ENST00000300576.5	+	18	2037	c.2037G>T	c.(2035-2037)ccG>ccT	p.P679P		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	679										ovary(1)	1						ACAACCCCCCGGTACAGCAGA	0.602000													5	71					5.9392e-07	6.20781e-07	1	1	0
TCL1A	8115	broad.mit.edu	37	14	96178093	96178093	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:96178093C>T	ENST00000402399.1	-	3	473	c.344G>A	c.(343-345)tGa>tAa	p.*115*	RP11-164H13.1_ENST00000553445.1_RNA|RP11-164H13.1_ENST00000547644.2_RNA|TCL1A_ENST00000556450.1_Silent_p.*115*|TCL1A_ENST00000555202.1_Silent_p.*115*|TCL1A_ENST00000554012.1_Silent_p.*115*	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	0					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CACCATACATCAGTCATCTGG	0.557000			T	TRA@	T-CLL								9	13					0	0	1	0	0
FZD8	8325	broad.mit.edu	37	10	35928705	35928705	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:35928705G>A	ENST00000374694.1	-	1	1657	c.1653C>T	c.(1651-1653)ctC>ctT	p.L551L		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	551					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GCTCGTAGAAGAGGCAGGCGA	0.697000													5	30					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13395961	13395961	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:13395961C>T	ENST00000360228.5	-	21	3612	c.3613G>A	c.(3613-3615)Gag>Aag	p.E1205K	CACNA1A_ENST00000573710.2_Missense_Mutation_p.E1206K	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1206	Poly-Glu.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	tcgtcttcctcctcctccttc	0.542000													14	52					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26178520	26178520	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:26178520G>A	ENST00000264712.3	-	3	2239	c.1660C>T	c.(1660-1662)Cgg>Tgg	p.R554W	KIF3C_ENST00000405914.1_Missense_Mutation_p.R554W	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	554					blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCATCTCCCGCTCACGACGT	0.602000													39	40					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45540973	45540973	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr21:45540973G>A	ENST00000291576.7	+	13	1753	c.1626G>A	c.(1624-1626)ctG>ctA	p.L542L		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	542						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CGCTGGCCCTGACCTCTGATG	0.607000													12	26					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020308	5020308	+	Silent	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:5020308C>G	ENST00000321543.1	+	1	96	c.96C>G	c.(94-96)ctC>ctG	p.L32L		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCCATCCTCTTCTGTCTTG	0.423000													9	184					0	0	1	0	0
GLCCI1	113263	broad.mit.edu	37	7	8110737	8110737	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:8110737G>A	ENST00000223145.5	+	6	1710	c.1153G>A	c.(1153-1155)Gat>Aat	p.D385N		NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	385										endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CTCAACAGAAGATTTGCTCTA	0.473000													26	117					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90173628	90173628	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:90173628G>A	ENST00000394412.3	-	16	3284	c.3208C>T	c.(3208-3210)Ctt>Ttt	p.L1070F		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1070					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GAGGCCCGAAGCACCCGCTGG	0.592000													3	33					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40122548	40122548	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:40122548G>C	ENST00000261435.6	+	9	3233	c.2817G>C	c.(2815-2817)aaG>aaC	p.K939N		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	939						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						AAAAACTAAAGACATTGGGTA	0.418000													12	46					0	0	1	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950336	2950336	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:2950336C>T	ENST00000314222.4	-	1	349	c.259G>A	c.(259-261)Gag>Aag	p.E87K		NM_003311.3	NP_003302.1	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain, family A, member 2	87	PH.				apoptosis	cytoplasm|membrane				central_nervous_system(1)	1		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCAGCTCTCGCCCGCGCAG	0.657000													11	29					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64974124	64974124	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:64974124C>T	ENST00000527323.1	+	12	1784	c.1544C>T	c.(1543-1545)tCa>tTa	p.S515L	CAPN1_ENST00000533820.1_Missense_Mutation_p.S515L|CAPN1_ENST00000279247.6_Missense_Mutation_p.S515L|CAPN1_ENST00000533129.1_Missense_Mutation_p.S515L|CAPN1_ENST00000524773.1_Missense_Mutation_p.S515L			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	515	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CGCTTCTTCTCAGAGAAGAGT	0.647000													8	48					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71158543	71158543	+	Silent	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:71158543G>T	ENST00000448642.2	+	22	3062	c.2673G>T	c.(2671-2673)gtG>gtT	p.V891V	HK1_ENST00000360289.2_Silent_p.V844V|HK1_ENST00000404387.2_Silent_p.V860V|HK1_ENST00000298649.3_Silent_p.V855V|HK1_ENST00000359426.6_Silent_p.V856V			P19367	HXK1_HUMAN	hexokinase 1	856	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						GTCTGAATGTGACTGTGGGAG	0.607000													7	85					0.00307968	0.00310958	1	1	0
PLEKHO1	51177	broad.mit.edu	37	1	150131230	150131230	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:150131230G>C	ENST00000369124.4	+	6	1020	c.742G>C	c.(742-744)Gac>Cac	p.D248H	PLEKHO1_ENST00000369126.1_Missense_Mutation_p.D65H|PLEKHO1_ENST00000025469.6_Missense_Mutation_p.D214H|PLEKHO1_ENST00000479194.1_3'UTR	NM_016274.4	NP_057358.2	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O member 1	248	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAAAAAACAGACAAAGGGGC	0.647000													27	25					0	0	1	0	0
GNB1	2782	broad.mit.edu	37	1	1721961	1721961	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:1721961G>C	ENST00000378609.4	-	9	903	c.572C>G	c.(571-573)tCt>tGt	p.S191C		NM_002074.3	NP_002065.1	P62873	GBB1_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1	191					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		AGGAGCAAGAGAAAGGCTCAT	0.577000													6	53					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140228529	140228529	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:140228529C>G	ENST00000378122.3	+	1	1173	c.449C>G	c.(448-450)tCt>tGt	p.S150C	PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S150C|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTTGACTCTCGGTTTCCA	0.542000													7	63					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	129999975	129999975	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:129999975G>C	ENST00000263574.5	+	11	1570	c.1498G>C	c.(1498-1500)Gag>Cag	p.E500Q	APLP2_ENST00000543137.1_Missense_Mutation_p.E407Q|APLP2_ENST00000539648.1_Missense_Mutation_p.E288Q|APLP2_ENST00000345598.5_Missense_Mutation_p.E271Q|APLP2_ENST00000528499.1_Missense_Mutation_p.E444Q|APLP2_ENST00000338167.5_Missense_Mutation_p.E500Q|APLP2_ENST00000278756.7_Missense_Mutation_p.E510Q	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	500					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGTCCGTGCTGAGAACAAAGA	0.468000													21	138					0	0	1	0	0
H3F3C	440093	broad.mit.edu	37	12	31944812	31944812	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:31944812C>T	ENST00000340398.3	-	1	363	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	97					nucleosome assembly	nucleosome|nucleus	DNA binding	p.E97K(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						AGGTACGCTTCGCTAGCCTCC	0.572000										HNSCC(67;0.2)			8	100					0	0	1	0	0
ALG8	79053	broad.mit.edu	37	11	77823813	77823813	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:77823813G>A	ENST00000376156.3	-	8	784	c.781C>T	c.(781-783)Cag>Tag	p.Q261*	ALG8_ENST00000532552.2_Intron|ALG8_ENST00000299626.5_Nonsense_Mutation_p.Q261*	NM_001007027.2	NP_001007028.1	Q9BVK2	ALG8_HUMAN	ALG8, alpha-1,3-glucosyltransferase	261					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	30	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			TGAGGCAGCTGATTCTGTTGA	0.393000													5	31					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371821	19371821	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:19371821G>T	ENST00000291481.7	-	3	348	c.285C>A	c.(283-285)ttC>ttA	p.F95L	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	95	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			AGACGTCGGTGAAGGCCAGCG	0.692000													15	57					5.03518e-11	5.37086e-11	1	1	0
DPYSL3	1809	broad.mit.edu	37	5	146777387	146777387	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:146777387C>T	ENST00000343218.5	-	12	1842	c.1645G>A	c.(1645-1647)Gaa>Aaa	p.E549K	DPYSL3_ENST00000534907.1_Missense_Mutation_p.E61K|DPYSL3_ENST00000398514.3_Missense_Mutation_p.E435K	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	435					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATCCCTTCAAAGATGTTG	0.567000													9	30					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12906731	12906731	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:12906731C>G	ENST00000380659.3	+	3	3243	c.3104C>G	c.(3103-3105)aCa>aGa	p.T1035R		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	1035	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	GCCCTGGCCACAGACAATCAT	0.517000													16	193					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78777160	78777160	+	Missense_Mutation	SNP	C	C	T	rs149176868		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:78777160C>T	ENST00000258886.8	+	12	1620	c.1471C>T	c.(1471-1473)Cat>Tat	p.H491Y		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	491							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TGTCTCCATTCATTATGAAGG	0.353000													4	63					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004055	75004055	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:75004055G>T	ENST00000373359.2	-	1	1024	c.832C>A	c.(832-834)Ccc>Acc	p.P278T		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	278	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGCTCCAGGGTTCTTCATCA	0.483000													7	81					0.0692343	0.0695688	1	1	0
ZNF561	93134	broad.mit.edu	37	19	9721178	9721178	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:9721178G>A	ENST00000302851.3	-	6	1522	c.1159C>T	c.(1159-1161)Cac>Tac	p.H387Y	ZNF561_ENST00000424629.1_Missense_Mutation_p.H318Y|ZNF561_ENST00000326044.5_3'UTR|ZNF561_ENST00000354661.4_Missense_Mutation_p.H251Y	NM_152289.2	NP_689502.2	Q8N587	ZN561_HUMAN	zinc finger protein 561	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	14						TCTCCTGTGTGAATTCTTGTA	0.403000													16	82					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153144112	153144112	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:153144112G>C	ENST00000285900.5	+	12	2285	c.1942G>C	c.(1942-1944)Gag>Cag	p.E648Q	GRIA1_ENST00000518142.1_Missense_Mutation_p.E568Q|GRIA1_ENST00000448073.4_Missense_Mutation_p.E658Q|GRIA1_ENST00000340592.5_Missense_Mutation_p.E648Q|GRIA1_ENST00000521843.2_Missense_Mutation_p.E579Q|GRIA1_ENST00000518783.1_Missense_Mutation_p.E658Q	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	648					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTCTCCCATTGAGAGTGCAGA	0.532000													3	54					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110837719	110837719	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:110837719G>C	ENST00000485303.1	+	3	994	c.719G>C	c.(718-720)aGa>aCa	p.R240T	PVRL3_ENST00000493615.1_Missense_Mutation_p.R217T|PVRL3_ENST00000319792.3_Missense_Mutation_p.R240T	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	240	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						AGATTTGCTAGAGGAAGGCGA	0.383000													45	45					0	0	1	0	0
TAF5	6877	broad.mit.edu	37	10	105145201	105145201	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:105145201C>G	ENST00000369839.3	+	8	1806	c.1783C>G	c.(1783-1785)Cca>Gca	p.P595A	TAF5_ENST00000351396.4_Intron	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	595					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACAATTTTCTCCATATGGATA	0.413000													10	39					0	0	1	0	0
GALNT1	2589	broad.mit.edu	37	18	33243677	33243677	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:33243677G>A	ENST00000269195.5	+	2	328	c.225G>A	c.(223-225)atG>atA	p.M75I	GALNT1_ENST00000591081.1_Missense_Mutation_p.M75I|GALNT1_ENST00000537549.1_Missense_Mutation_p.M15I	NM_020474.3	NP_065207.2	Q10472	GALT1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	75					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(4)|stomach(1)	21						AAGAAAAGATGAAAGAGATGT	0.378000													24	50					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39224544	39224544	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:39224544C>G	ENST00000426016.1	-	19	2900	c.2814G>C	c.(2812-2814)ttG>ttC	p.L938F	SOS1_ENST00000395038.2_Missense_Mutation_p.L938F|SOS1_ENST00000402219.2_Missense_Mutation_p.L938F			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	938	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CTTCTGTTTTCAAGATATTAG	0.333000									Noonan syndrome				14	50					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1714321	1714321	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:1714321G>C	ENST00000313871.3	+	3	1003	c.807G>C	c.(805-807)aaG>aaC	p.K269N	AKAP17A_ENST00000381261.3_Missense_Mutation_p.K269N	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	269					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						CCTCAATTAAGAAGCGGCAGC	0.517000													33	150					0	0	1	0	0
ACE2	59272	broad.mit.edu	37	X	15605910	15605910	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:15605910G>C	ENST00000427411.1	-	7	984	c.768C>G	c.(766-768)atC>atG	p.I256M	ACE2_ENST00000252519.3_Missense_Mutation_p.I256M	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	256					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	CAATTGGACTGATATAGGAAG	0.388000													10	201					0	0	1	0	0
RTN2	6253	broad.mit.edu	37	19	45998252	45998252	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:45998252C>T	ENST00000245923.4	-	3	326	c.91G>A	c.(91-93)Gac>Aac	p.D31N	RTN2_ENST00000344680.4_Missense_Mutation_p.D31N|RTN2_ENST00000589384.1_5'UTR|RTN2_ENST00000590526.1_5'UTR|PPM1N_ENST00000401705.1_Intron	NM_005619.4	NP_005610.1	O75298	RTN2_HUMAN	reticulon 2	31						integral to endoplasmic reticulum membrane	signal transducer activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(4)|skin(1)|urinary_tract(1)	20		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		AAATCAGAGTCGTCGTTCCCT	0.622000													19	54					0	0	1	0	0
MUT	4594	broad.mit.edu	37	6	49421348	49421348	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:49421348G>C	ENST00000274813.3	-	5	1160	c.1033C>G	c.(1033-1035)Ctt>Gtt	p.L345V		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	345					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTTAGAAGAAGAGATTTTGAG	0.318000													10	186					0	0	1	0	0
ZNF607	84775	broad.mit.edu	37	19	38198843	38198843	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:38198843C>T	ENST00000355202.4	-	4	802	c.207G>A	c.(205-207)gtG>gtA	p.V69V	ZNF607_ENST00000395835.3_Silent_p.V68V|CTD-2528L19.4_ENST00000586606.2_Silent_p.V69V	NM_032689.4	NP_116078.4	Q96SK3	ZN607_HUMAN	zinc finger protein 607	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|lung(8)|urinary_tract(1)	27			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TTTCTTCCCTCACAATCATCC	0.438000													15	58					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27328913	27328913	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:27328913G>A	ENST00000376087.4	-	21	2521	c.2356C>T	c.(2356-2358)Cga>Tga	p.R786*	ANKRD26_ENST00000376070.3_Nonsense_Mutation_p.R343*|ANKRD26_ENST00000436985.2_Nonsense_Mutation_p.R802*	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	785						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						CACAGTTCTCGTTCCCATTCA	0.299000													7	98					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24449853	24449853	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:24449853G>T	ENST00000270800.1	-	6	769	c.731C>A	c.(730-732)gCa>gAa	p.A244E		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	244						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCAGAGTACTGCGACGAGGAA	0.612000													22	18					1.10923e-09	1.17714e-09	1	1	0
CYP11B1	1584	broad.mit.edu	37	8	143957662	143957662	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:143957662C>G	ENST00000292427.4	-	5	981	c.949G>C	c.(949-951)Gac>Cac	p.D317H	CYP11B1_ENST00000517471.1_Missense_Mutation_p.D317H|CYP11B1_ENST00000377675.3_Missense_Mutation_p.D388H	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	317					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTGACCGTGTCCACGCTCCCT	0.617000									Familial Hyperaldosteronism type I				29	79					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134017270	134017270	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:134017270C>T	ENST00000338492.4	+	13	1630	c.1466C>T	c.(1465-1467)gCg>gTg	p.A489V	DPYSL4_ENST00000368627.1_Missense_Mutation_p.A329V|DPYSL4_ENST00000368629.1_Missense_Mutation_p.A329V	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	489					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CGGCAGCTGGCGGAGATCCAC	0.716000													21	29					0	0	1	0	0
CNTD2	79935	broad.mit.edu	37	19	40730538	40730538	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:40730538G>C	ENST00000430325.2	-	3	418	c.370C>G	c.(370-372)Ctg>Gtg	p.L124V	CNTD2_ENST00000433940.1_Missense_Mutation_p.L94V|CNTD2_ENST00000513948.1_Missense_Mutation_p.L18V	NM_024877.3	NP_079153.2	B4DX65	B4DX65_HUMAN	cyclin N-terminal domain containing 2	124					regulation of cyclin-dependent protein kinase activity		protein kinase binding			lung(1)|prostate(1)	2						TCACCAGCCAGACCCAGGTAC	0.637000													11	36					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47230793	47230793	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:47230793G>A	ENST00000391910.3	-	9	1635	c.1185C>T	c.(1183-1185)atC>atT	p.I395I	STRN4_ENST00000263280.6_Silent_p.I388I|STRN4_ENST00000539396.1_Silent_p.I269I|STRN4_ENST00000594357.2_5'UTR			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	388						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		TAGTGTCCATGATGAAGACGT	0.602000													13	26					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41486212	41486212	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41486212C>G	ENST00000359345.1	-	1	2697	c.121G>C	c.(121-123)Gag>Cag	p.E41Q	SLFNL1_ENST00000397197.2_Missense_Mutation_p.E41Q|SLFNL1_ENST00000439569.2_Missense_Mutation_p.E41Q|SLFNL1_ENST00000302946.8_Missense_Mutation_p.E41Q|SLFNL1_ENST00000372611.1_Missense_Mutation_p.E41Q|SLFNL1_ENST00000372613.2_Missense_Mutation_p.E41Q	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	41							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GGAGCCTCCTCGAGGTCAGAG	0.632000													15	104					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71650506	71650506	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:71650506C>G	ENST00000409544.1	+	22	4492	c.3862C>G	c.(3862-3864)Ccc>Gcc	p.P1288A	ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000409407.1_Missense_Mutation_p.P228A|ZNF638_ENST00000264447.4_Missense_Mutation_p.P1288A	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1288	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						ACCAGGAATTCCCACTGGGGA	0.368000													8	52					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34663884	34663884	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:34663884G>A	ENST00000374789.3	-	11	1911	c.1586C>T	c.(1585-1587)tCg>tTg	p.S529L	PARD3_ENST00000544292.1_Missense_Mutation_p.S259L|PARD3_ENST00000374790.3_Missense_Mutation_p.S485L|PARD3_ENST00000545260.1_Missense_Mutation_p.S485L|PARD3_ENST00000374794.3_Missense_Mutation_p.S485L|PARD3_ENST00000340077.5_Missense_Mutation_p.S529L|PARD3_ENST00000350537.4_Missense_Mutation_p.S529L|PARD3_ENST00000374788.3_Missense_Mutation_p.S529L|PARD3_ENST00000374773.1_Missense_Mutation_p.S529L|PARD3_ENST00000346874.4_Missense_Mutation_p.S529L|PARD3_ENST00000374776.1_Missense_Mutation_p.S529L|PARD3_ENST00000545693.1_Missense_Mutation_p.S529L	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	529	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TCTCAACAGCGAAACAACTTC	0.433000													39	73					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16348428	16348428	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:16348428G>A	ENST00000408042.1	-	23	3699	c.3542C>T	c.(3541-3543)gCc>gTc	p.A1181V	KIF16B_ENST00000378003.2_Intron|KIF16B_ENST00000355755.3_Intron|KIF16B_ENST00000354981.2_Intron	NM_001199866.1	NP_001186795.1	Q96L93	KI16B_HUMAN	kinesin family member 16B	0					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GCAGGCAGCGGCATCAGGCTC	0.478000													5	32					0	0	1	0	0
SARNP	84324	broad.mit.edu	37	12	56188646	56188646	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:56188646C>T	ENST00000444631.2	-	5	295	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	SARNP_ENST00000336133.3_Missense_Mutation_p.E108K|RP11-762I7.5_ENST00000546837.1_Silent_p.*420*|SARNP_ENST00000552080.1_Missense_Mutation_p.E108K					SAP domain containing ribonucleoprotein											breast(1)|endometrium(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	6						TTGAATCGTTCAGCCCTCTTC	0.418000													7	18					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192815	123192815	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:123192815C>G	ENST00000264501.4	+	47	8509	c.8136C>G	c.(8134-8136)ttC>ttG	p.F2712L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.F2712L|KIAA1109_ENST00000455637.1_Missense_Mutation_p.F2712L			Q2LD37	K1109_HUMAN	KIAA1109	2712					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGCTTAACTTCTATTCACTTA	0.348000													6	50					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100331181	100331181	+	RNA	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:100331181C>G	ENST00000341853.1	-	0	3010					NR_003260.1																						TCCCTTTCATCTTTGTCATTG	0.572000													76	89					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40121580	40121580	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:40121580G>C	ENST00000261435.6	+	9	2265	c.1849G>C	c.(1849-1851)Gaa>Caa	p.E617Q		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	617						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TATTATCTCTGAAAAAGAAGA	0.308000													10	72					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8201290	8201290	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:8201290C>T	ENST00000600128.1	-	11	1741	c.1327G>A	c.(1327-1329)Gtg>Atg	p.V443M	FBN3_ENST00000601739.1_Missense_Mutation_p.V443M|FBN3_ENST00000270509.2_Missense_Mutation_p.V443M			Q75N90	FBN3_HUMAN	fibrillin 3	443	EGF-like 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TCGCCGCGCACGTCCTGGGTG	0.647000													4	71					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71158502	71158502	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:71158502G>C	ENST00000448642.2	+	22	3021	c.2632G>C	c.(2632-2634)Gat>Cat	p.D878H	HK1_ENST00000360289.2_Missense_Mutation_p.D831H|HK1_ENST00000404387.2_Missense_Mutation_p.D847H|HK1_ENST00000298649.3_Missense_Mutation_p.D842H|HK1_ENST00000359426.6_Missense_Mutation_p.D843H			P19367	HXK1_HUMAN	hexokinase 1	843	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TGCGGTTGTGGATAAGATCCG	0.582000													6	89					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124744063	124744063	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:124744063C>T	ENST00000397801.1	+	12	2074	c.1882C>T	c.(1882-1884)Ctg>Ttg	p.L628L	ROBO3_ENST00000538940.1_Silent_p.L606L	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	628	Fibronectin type-III 1.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTACCTGTTTCTGGTTCGAGC	0.602000													5	150					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41142889	41142889	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr21:41142889G>C	ENST00000380588.4	+	4	568	c.465G>C	c.(463-465)gaG>gaC	p.E155D	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	155	Ig-like V-type 2.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TAGTCGCTGAGAATGAACCTT	0.463000													12	50					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155385641	155385641	+	Missense_Mutation	SNP	A	A	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:155385641A>C	ENST00000368346.3	-	6	6541	c.5902T>G	c.(5902-5904)Ttg>Gtg	p.L1968V	ASH1L_ENST00000392403.3_Missense_Mutation_p.L1968V			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1968					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACAGGCTGCAAGGTACTTTCA	0.438000													15	73					0	0	1	0	0
HIF1AN	55662	broad.mit.edu	37	10	102304755	102304755	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:102304755C>G	ENST00000299163.5	+	4	725	c.625C>G	c.(625-627)Cag>Gag	p.Q209E		NM_017902.2	NP_060372.2	Q9NWT6	HIF1N_HUMAN	hypoxia inducible factor 1, alpha subunit inhibitor	209	Interaction with HIF1A.|Interaction with VHL.|JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	10		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CTTTTTTGCTCAGATAAAAGG	0.448000													15	64					0	0	1	0	0
CNTD1	124817	broad.mit.edu	37	17	40957871	40957871	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:40957871G>C	ENST00000588408.1	+	4	825	c.549G>C	c.(547-549)ctG>ctC	p.L183L	CNTD1_ENST00000315066.5_3'UTR|CNTD1_ENST00000588527.1_Silent_p.L100L	NM_173478.2	NP_775749.2	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	183										central_nervous_system(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCACTCCCCTGGCATATGTGG	0.453000													13	43					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130827556	130827556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr12:130827556C>T	ENST00000245255.3	+	3	372	c.100C>T	c.(100-102)Cag>Tag	p.Q34*		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	34					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TGGTTATATTCAGCCTAGGCC	0.478000													17	42					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134147433	134147433	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:134147433C>T	ENST00000452510.2	+	18	2492	c.2334C>T	c.(2332-2334)ttC>ttT	p.F778F	DDX46_ENST00000354283.4_Silent_p.F778F	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	778					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding	p.F778F(1)		NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAAGGGATTCAAGTTTGATG	0.353000													15	58					0	0	1	0	0
PRPF40A	55660	broad.mit.edu	37	2	153530178	153530178	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:153530178C>G	ENST00000410080.1	-	11	1615	c.1074G>C	c.(1072-1074)aaG>aaC	p.K358N		NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	385					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						TGTATGTTTTCTTTGCTGGTT	0.299000													3	36					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115536935	115536935	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:115536935G>C	ENST00000354462.3	+	5	492	c.334G>C	c.(334-336)Gat>Cat	p.D112H	PLEKHS1_ENST00000361048.1_Intron|PLEKHS1_ENST00000369312.4_Missense_Mutation_p.D280H|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.D362H|PLEKHS1_ENST00000369309.1_Missense_Mutation_p.D196H					pleckstrin homology domain containing, family S member 1																		TTGCCACGGAGATCATCTTCT	0.547000													5	29					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935705	56935705	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:56935705C>T	ENST00000333201.9	+	5	1888	c.1678C>T	c.(1678-1680)Cag>Tag	p.Q560*	ZNF583_ENST00000291598.7_Nonsense_Mutation_p.Q560*|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q560K(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		cacatcaaatcagttgccaag	0.423000													7	12					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32023733	32023733	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:32023733C>T	ENST00000375244.3	-	24	8563	c.8362G>A	c.(8362-8364)Gag>Aag	p.E2788K	TNXB_ENST00000375247.2_Missense_Mutation_p.E2788K			P22105	TENX_HUMAN	tenascin XB	2846					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACGGTGACCTCGCTCTCCTCG	0.687000													22	69					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41483474	41483474	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41483474C>T	ENST00000359345.1	-	2	3366	c.790G>A	c.(790-792)Gac>Aac	p.D264N	SLFNL1_ENST00000397197.2_Missense_Mutation_p.D264N|SLFNL1_ENST00000439569.2_Missense_Mutation_p.D264N|SLFNL1_ENST00000302946.8_Missense_Mutation_p.D264N|SLFNL1_ENST00000372611.1_Missense_Mutation_p.D205N|SLFNL1_ENST00000372613.2_Missense_Mutation_p.D264N	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	264							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				AGGCCGCTGTCCTCTACTCCC	0.662000													14	57					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215880343	215880343	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:215880343G>A	ENST00000272895.7	-	15	2046	c.1827C>T	c.(1825-1827)atC>atT	p.I609I	ABCA12_ENST00000389661.4_Silent_p.I291I	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	609					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGGGAGTGGTGATATTAGTAT	0.423000													20	24					0	0	1	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782485	27782485	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:27782485G>A	ENST00000333151.3	-	1	122	c.34C>T	c.(34-36)Cgc>Tgc	p.R12C		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	12					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						GCCTTGGCGCGAGCTTTGCCT	0.542000													8	66					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11367475	11367475	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:11367475G>A	ENST00000315872.6	-	6	1221	c.773C>T	c.(772-774)tCa>tTa	p.S258L	ROCK2_ENST00000401753.1_Missense_Mutation_p.S15L	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	258	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AACCTCAGGTGATATATAATC	0.423000													38	222					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49163465	49163465	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:49163465G>A	ENST00000418109.1	-	18	2443	c.2279C>T	c.(2278-2280)tCt>tTt	p.S760F	LAMB2_ENST00000305544.4_Missense_Mutation_p.S760F	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	760	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTCAGAGGGAGAAGTCTTGCT	0.597000													33	20					0	0	1	0	0
DHPS	1725	broad.mit.edu	37	19	12786738	12786738	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:12786738C>T	ENST00000210060.7	-	9	1159	c.1024G>A	c.(1024-1026)Gac>Aac	p.D342N	DHPS_ENST00000594424.1_Missense_Mutation_p.D300N|DHPS_ENST00000351660.5_Missense_Mutation_p.D295N	NM_001930.3	NP_001921.1	P49366	DHYS_HUMAN	deoxyhypusine synthase	342					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8					Sulfadoxine(DB01299)	AGGGAGGCGTCAGCATAGACC	0.607000											OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	43					0	0	1	0	0
PPEF1	5475	broad.mit.edu	37	X	18725777	18725777	+	Splice_Site	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:18725777G>C	ENST00000361511.4	+	4	372		c.e4-1		PPEF1_ENST00000349874.5_Splice_Site|PPEF1_ENST00000471570.1_Splice_Site|PPEF1_ENST00000544635.1_5'UTR|PPEF1_ENST00000543630.1_Splice_Site|PPEF1_ENST00000359763.6_Splice_Site	NM_006240.2|NM_152224.1	NP_006231.2|NP_689410.1	O14829	PPE1_HUMAN	protein phosphatase, EF-hand calcium binding domain 1						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					TTCCTCATTAGAATCTATGAC	0.458000													3	8					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54664081	54664081	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:54664081G>A	ENST00000376591.4	-	15	2232	c.2101C>T	c.(2101-2103)Cgc>Tgc	p.R701C	TMC4_ENST00000416963.1_Missense_Mutation_p.R283C|TMC4_ENST00000301187.4_Missense_Mutation_p.R695C	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	701						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCACAGCGCGCCGTGCCAGG	0.612000													26	74					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105261043	105261043	+	Splice_Site	SNP	T	T	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:105261043T>A	ENST00000507740.1	+	19	3267		c.e19+2		RIMS2_ENST00000436393.2_Splice_Site|RIMS2_ENST00000339750.2_Splice_Site|RIMS2_ENST00000406091.3_Splice_Site|RIMS2_ENST00000262231.10_Splice_Site	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2						intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTGCAATGGGTAAGAATTTCT	0.438000										HNSCC(12;0.0054)			5	101					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166767949	166767949	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:166767949C>T	ENST00000243344.7	-	18	2486	c.2349G>A	c.(2347-2349)ctG>ctA	p.L783L		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	783						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						GTCCAGTTTTCAGAGCAGCTT	0.358000													17	61					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28251760	28251760	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:28251760G>A	ENST00000405948.2	+	2	590	c.170G>A	c.(169-171)gGa>gAa	p.G57E	PGBD1_ENST00000259883.3_Missense_Mutation_p.G57E	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	57	SCAN box.				viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						GAGGCTCACGGACCCCAGGAA	0.587000													23	56					0	0	1	0	0
RXFP4	339403	broad.mit.edu	37	1	155912577	155912577	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:155912577C>T	ENST00000368318.3	+	1	1098	c.1077C>T	c.(1075-1077)agC>agT	p.S359S		NM_181885.2	NP_871001.1	Q8TDU9	RL3R2_HUMAN	relaxin/insulin-like family peptide receptor 4	359						integral to membrane|plasma membrane	angiotensin type II receptor activity			endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	13	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCCGGGAGAGCCGCCCTTCTA	0.632000													3	56					0	0	1	0	0
SLFNL1	200172	broad.mit.edu	37	1	41486281	41486281	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41486281C>T	ENST00000359345.1	-	1	2628	c.52G>A	c.(52-54)Gag>Aag	p.E18K	SLFNL1_ENST00000397197.2_Missense_Mutation_p.E18K|SLFNL1_ENST00000439569.2_Missense_Mutation_p.E18K|SLFNL1_ENST00000302946.8_Missense_Mutation_p.E18K|SLFNL1_ENST00000372611.1_Missense_Mutation_p.E18K|SLFNL1_ENST00000372613.2_Missense_Mutation_p.E18K	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	18							ATP binding			endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCCCAGGACTCCATGAAGGGC	0.607000													11	82					0	0	1	0	0
SAYSD1	55776	broad.mit.edu	37	6	39082745	39082745	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:39082745G>C	ENST00000229903.4	-	1	220	c.121C>G	c.(121-123)Cta>Gta	p.L41V	SAYSD1_ENST00000481599.1_5'UTR	NM_018322.1	NP_060792.1	Q9NPB0	CF064_HUMAN	SAYSVFN motif domain containing 1	41	Ala-rich.					integral to membrane											GCTGCCTTTAGAGTCGCTGCT	0.667000													12	52					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282561	152282561	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:152282561C>G	ENST00000368799.1	-	3	4836	c.4801G>C	c.(4801-4803)Gag>Cag	p.E1601Q	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1601	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTGTCCCTCACTGTCCCTG	0.592000									Ichthyosis				50	182					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212118198	212118198	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:212118198G>C	ENST00000366994.3	-	19	2633	c.2529C>G	c.(2527-2529)ctC>ctG	p.L843L	INTS7_ENST00000366992.3_Silent_p.L823L|INTS7_ENST00000440600.2_Silent_p.L794L|INTS7_ENST00000366993.3_Silent_p.L829L|INTS7_ENST00000469606.1_5'UTR	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	843					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTTTGCGGAAGAGTCCTGGTT	0.478000													4	96					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455853	83455853	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:83455853C>T	ENST00000334574.8	-	2	471	c.290G>A	c.(289-291)aGa>aAa	p.R97K	FSD2_ENST00000541889.1_Missense_Mutation_p.R97K			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	97										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						AACCCCTGTTCTGGGTATGTT	0.468000													30	112					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19222139	19222139	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr22:19222139G>A	ENST00000263200.10	-	7	1132	c.1060C>T	c.(1060-1062)Cgt>Tgt	p.R354C	CLTCL1_ENST00000427926.1_Missense_Mutation_p.R354C|CLTCL1_ENST00000353891.5_Missense_Mutation_p.R354C	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	354	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					AGGTTACTACGAACGGCCAAA	0.483000			T	?	ALCL								10	114					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75115958	75115958	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:75115958G>A	ENST00000309664.5	+	12	1397	c.1258G>A	c.(1258-1260)Gag>Aag	p.E420K	RP11-414J4.2_ENST00000564823.1_RNA|LMAN1L_ENST00000379709.3_Missense_Mutation_p.E408K	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	420						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGTGGGCATTGAGCATCATTT	0.597000													18	62					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99102182	99102182	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:99102182C>T	ENST00000318528.3	+	2	1296	c.937C>T	c.(937-939)Cga>Tga	p.R313*	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	313	Glu-rich.									kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GCATCCAGCACGAAATGTAGA	0.443000													29	146					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176002508	176002508	+	Splice_Site	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:176002508G>A	ENST00000510636.1	+	10	1044	c.768_splice	c.e10-1	p.G257_splice	CDHR2_ENST00000261944.5_Splice_Site_p.G257_splice|CDHR2_ENST00000506348.1_Splice_Site_p.G257_splice	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	257	Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CCATTCCAGGGAACCTCGGTG	0.632000													6	146					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73803494	73803494	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:73803494C>T	ENST00000334126.7	-	19	3710	c.3484G>A	c.(3484-3486)Gag>Aag	p.E1162K	C2CD3_ENST00000313663.7_Missense_Mutation_p.E1162K			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1162						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TTCCTGTTCTCAATCCTGGGG	0.388000													34	101					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110905540	110905540	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:110905540G>C	ENST00000316534.4	-	13	1463	c.1390C>G	c.(1390-1392)Cca>Gca	p.P464A	NPHP1_ENST00000417665.1_Missense_Mutation_p.P407A|NPHP1_ENST00000393272.3_Missense_Mutation_p.P463A|NPHP1_ENST00000445609.2_Missense_Mutation_p.P408A|NPHP1_ENST00000355301.4_Missense_Mutation_p.P345A			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	463					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						CCAAGATCTGGAGATGCAGAA	0.318000													23	94					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8721083	8721083	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr20:8721083G>C	ENST00000378641.3	+	22	2876	c.2401G>C	c.(2401-2403)Gac>Cac	p.D801H	PLCB1_ENST00000378637.2_Missense_Mutation_p.D801H|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000338037.6_Missense_Mutation_p.D801H	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	801					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTATGTGCCAGACACATATGC	0.408000													16	60					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45431675	45431675	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:45431675C>T	ENST00000361462.2	+	1	234	c.51C>T	c.(49-51)ctC>ctT	p.L17L	FAM179B_ENST00000361577.3_Silent_p.L17L|FAM179B_ENST00000382233.2_Silent_p.L17L			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	17							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						TTCCAGTCCTCTCTACCTATC	0.582000													7	17					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73490824	73490824	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:73490824G>T	ENST00000314256.7	+	19	2918	c.2524G>T	c.(2524-2526)Gat>Tat	p.D842Y	KIAA0195_ENST00000579208.1_Missense_Mutation_p.D493Y|KIAA0195_ENST00000375248.5_Missense_Mutation_p.D852Y	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	842					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGCCTCATTGATGGGCTTGT	0.577000													15	112					3.32936e-07	3.49751e-07	1	1	0
HIST1H2AI	8329	broad.mit.edu	37	6	27776021	27776021	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:27776021C>T	ENST00000358739.3	+	1	123	c.34C>T	c.(34-36)Cgc>Tgc	p.R12C		NM_003509.2	NP_003500.1			histone cluster 1, H2ai											lung(3)	3						AGGCAAAGCTCGCGCCAAGGC	0.552000													8	149					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30831131	30831131	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:30831131G>C	ENST00000265299.6	+	5	1091	c.1014G>C	c.(1012-1014)atG>atC	p.M338I	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	338										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATTCCAGGATGACCCAGGAGA	0.587000													13	36					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63445233	63445233	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:63445233C>G	ENST00000453546.1	-	10	1512	c.1423G>C	c.(1423-1425)Gac>Cac	p.D475H	ASB12_ENST00000362002.2_Missense_Mutation_p.D100H|ASB12_ENST00000396130.2_Missense_Mutation_p.D91H			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TCCAAGCTGTCAACATCAGCA	0.552000													3	20					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73438989	73438989	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:73438989C>T	ENST00000263666.4	-	7	1508	c.1394G>A	c.(1393-1395)cGa>cAa	p.R465Q	PDZRN3_ENST00000466780.1_Missense_Mutation_p.R122Q|PDZRN3_ENST00000466348.1_5'UTR|PDZRN3_ENST00000479530.1_Missense_Mutation_p.R182Q|PDZRN3_ENST00000535920.1_Missense_Mutation_p.R187Q|PDZRN3_ENST00000462146.2_Missense_Mutation_p.R122Q	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	465	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTCTCCTTCTCGGATGCGCCC	0.478000													4	98					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64026970	64026970	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:64026970G>C	ENST00000443617.2	-	13	2686	c.2599C>G	c.(2599-2601)Ctt>Gtt	p.L867V		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	867					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TGAGGTAAAAGAGAATGAAGT	0.388000													14	21					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105511743	105511743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:105511743G>A	ENST00000276654.5	-	4	385	c.277C>T	c.(277-279)Cag>Tag	p.Q93*	LRP12_ENST00000424843.2_Nonsense_Mutation_p.Q74*	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	93	CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCAAAATCCTGAAAACTGAAA	0.299000													5	56					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98244475	98244475	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr9:98244475A>G	ENST00000430669.2	-	4	982	c.397T>C	c.(397-399)Ttg>Ctg	p.L133L	PTCH1_ENST00000418258.1_Silent_p.L48L|PTCH1_ENST00000421141.1_Silent_p.L48L|PTCH1_ENST00000375274.2_Silent_p.L198L|PTCH1_ENST00000548379.1_5'UTR|PTCH1_ENST00000468211.2_Silent_p.L133L|PTCH1_ENST00000331920.6_Silent_p.L199L|PTCH1_ENST00000429896.2_Silent_p.L48L|PTCH1_ENST00000437951.1_Silent_p.L133L			Q13635	PTC1_HUMAN	patched 1	199					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAATGTTCCAATTTCCACTGC	0.323000													10	17					0	0	1	0	0
C11orf84	144097	broad.mit.edu	37	11	63585793	63585793	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:63585793C>G	ENST00000294244.4	+	3	862	c.563C>G	c.(562-564)cCt>cGt	p.P188R		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	188	Pro-rich.									endometrium(3)|kidney(1)|lung(3)|skin(1)	8						CCATCCCTCCCTAAAAGGAGC	0.632000													4	87					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89964965	89964965	+	Splice_Site	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:89964965G>C	ENST00000263346.8	+	10	1079	c.1022_splice	c.e10-1	p.R341_splice	TCF25_ENST00000263347.7_Splice_Site_p.R106_splice	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	341					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TTGGATCTAGGAGCTTCTACC	0.577000													48	145					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66360198	66360198	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:66360198C>T	ENST00000333861.3	-	1	356	c.289G>A	c.(289-291)Gag>Aag	p.E97K		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	97										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCGGGCGGCTCCCGCCAGCTG	0.632000											OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10087239	10087239	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:10087239G>A	ENST00000264828.3	-	45	3422	c.3337C>T	c.(3337-3339)Ccc>Tcc	p.P1113S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1113	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTCACCGGGGGACCTGGGTGT	0.532000													3	9					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802465	185802465	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:185802465C>T	ENST00000302277.6	+	4	2936	c.2342C>T	c.(2341-2343)tCa>tTa	p.S781L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	781						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TCTTATTCTTCAGATGAAAGT	0.373000													12	36					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610393	38610393	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:38610393C>T	ENST00000222345.6	+	9	3248	c.2739C>T	c.(2737-2739)tgC>tgT	p.C913C		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	913					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACTGCTACTGCGGGGATGTCA	0.532000													5	141					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68181430	68181430	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:68181430G>A	ENST00000294304.7	+	12	2883	c.2777G>A	c.(2776-2778)tGc>tAc	p.C926Y		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	926	EGF-like 3.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGCCACCGCTGCGGCTGCGCC	0.647000													9	36					0	0	1	0	0
SRR	63826	broad.mit.edu	37	17	2224685	2224685	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:2224685G>C	ENST00000344595.5	+	5	803	c.485G>C	c.(484-486)gGa>gCa	p.G162A	SRR_ENST00000576848.1_Intron	NM_021947.1	NP_068766.1	Q9GZT4	SRR_HUMAN	serine racemase	162					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity			NS(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GTGATAGCTGGACAAGGGACA	0.413000													27	70					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50724737	50724737	+	Missense_Mutation	SNP	G	G	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:50724737G>T	ENST00000404971.1	-	15	4072	c.2733C>A	c.(2731-2733)agC>agA	p.S911R	NRXN1_ENST00000406859.3_Missense_Mutation_p.S871R|NRXN1_ENST00000402717.3_Missense_Mutation_p.S863R|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.S871R|NRXN1_ENST00000405472.3_Missense_Mutation_p.S863R|NRXN1_ENST00000401669.2_Missense_Mutation_p.S871R	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	871	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TAAATGTCAAGCTCTGCAGGT	0.433000													7	39					5.18039e-06	5.33426e-06	1	1	0
SLFNL1	200172	broad.mit.edu	37	1	41483477	41483477	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:41483477C>A	ENST00000359345.1	-	2	3363	c.787G>T	c.(787-789)Gag>Tag	p.E263*	SLFNL1_ENST00000397197.2_Nonsense_Mutation_p.E263*|SLFNL1_ENST00000439569.2_Nonsense_Mutation_p.E263*|SLFNL1_ENST00000302946.8_Nonsense_Mutation_p.E263*|SLFNL1_ENST00000372611.1_Nonsense_Mutation_p.E204*|SLFNL1_ENST00000372613.2_Nonsense_Mutation_p.E263*	NM_144990.3	NP_659427.3	Q499Z3	SLNL1_HUMAN	schlafen-like 1	263							ATP binding	p.E263Q(1)		endometrium(3)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCGCTGTCCTCTACTCCCACG	0.672000													14	58					2.32078e-09	2.45037e-09	1	1	0
ADCK1	57143	broad.mit.edu	37	14	78399726	78399726	+	Missense_Mutation	SNP	C	C	G	rs141850399		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:78399726C>G	ENST00000238561.5	+	11	1663	c.1564C>G	c.(1564-1566)Cca>Gca	p.P522A	ADCK1_ENST00000341211.5_Missense_Mutation_p.P454A|ADCK1_ENST00000556560.1_3'UTR	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	529						extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GTTCCCTGCTCCACTCTGAGT	0.557000													4	120					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43328728	43328728	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:43328728G>A	ENST00000290650.4	-	18	2164	c.2086C>T	c.(2086-2088)Cag>Tag	p.Q696*	UBR1_ENST00000382177.2_Nonsense_Mutation_p.Q696*	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	696					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ATAGGTACCTGAAGCATGATG	0.269000													36	74					0	0	1	0	0
TMEM87A	25963	broad.mit.edu	37	15	42510006	42510006	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:42510006C>T	ENST00000389834.4	-	19	1885	c.1621G>A	c.(1621-1623)Gat>Aat	p.D541N	RP11-546B15.1_ENST00000563846.1_RNA|TMEM87A_ENST00000448392.1_Missense_Mutation_p.D480N	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	541						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		CCAACCTCATCTGAATCCAGA	0.343000													36	54					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625613	154625613	+	Silent	SNP	A	A	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:154625613A>G	ENST00000260010.6	+	1	2962	c.1554A>G	c.(1552-1554)caA>caG	p.Q518Q		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	518					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				CTAAGGAGCAACTTGACTCAT	0.428000													45	39					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465569	70465569	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:70465569C>A	ENST00000373998.1	-	17	3470	c.2773G>T	c.(2773-2775)Gaa>Taa	p.E925*	ZMYM3_ENST00000373984.3_Nonsense_Mutation_p.E939*|ZMYM3_ENST00000314425.5_Nonsense_Mutation_p.E937*|ZMYM3_ENST00000373988.1_Nonsense_Mutation_p.E939*|ZMYM3_ENST00000353904.2_Nonsense_Mutation_p.E937*|ZMYM3_ENST00000489332.1_5'UTR	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	937					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GCAATCATTTCTGCCATAGCC	0.527000													7	41					0.00307968	0.00310958	1	1	0
HDLBP	3069	broad.mit.edu	37	2	242206264	242206264	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr2:242206264C>G	ENST00000391975.1	-	3	248	c.21G>C	c.(19-21)ttG>ttC	p.L7F	HDLBP_ENST00000427183.2_Missense_Mutation_p.L43F|HDLBP_ENST00000391976.2_Missense_Mutation_p.L7F|HDLBP_ENST00000310931.4_Missense_Mutation_p.L7F	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	7					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCTCTTGGGTCAAAACTGCAA	0.443000													4	107					0	0	1	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26124097	26124097	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:26124097C>T	ENST00000314332.5	-	1	41	c.36G>A	c.(34-36)aaG>aaA	p.K12K	HIST1H2BC_ENST00000396984.1_Silent_p.K12K			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	12					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						TGGAGCCCTTCTTCGGGGCGG	0.512000													23	115					0	0	1	0	0
RDH8	50700	broad.mit.edu	37	19	10127876	10127876	+	Missense_Mutation	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:10127876G>C	ENST00000591589.1	+	2	496	c.307G>C	c.(307-309)Gaa>Caa	p.E103Q	RDH8_ENST00000171214.1_Missense_Mutation_p.E83Q			Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	83					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			endometrium(3)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|prostate(1)	21			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TATCCAGGGAGAAGTGGACGT	0.602000													14	28					0	0	1	0	0
MARVELD3	91862	broad.mit.edu	37	16	71674454	71674454	+	Missense_Mutation	SNP	C	C	T	rs140602857		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:71674454C>T	ENST00000299952.4	+	3	800	c.757C>T	c.(757-759)Cgg>Tgg	p.R253W	PHLPP2_ENST00000540628.1_3'UTR|MARVELD3_ENST00000565261.1_3'UTR|MARVELD3_ENST00000561682.1_Intron	NM_001017967.2	NP_001017967.2	Q96A59	MALD3_HUMAN	MARVEL domain containing 3	256	MARVEL.					integral to membrane				NS(1)|endometrium(3)|large_intestine(5)|lung(6)|skin(2)	17		Ovarian(137;0.125)				AGAGCAGGTTCGGCAGCTGGA	0.577000													23	90					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56205245	56205245	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:56205245C>G	ENST00000361673.3	-	5	2387	c.2174G>C	c.(2173-2175)aGa>aCa	p.R725T	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	725							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GTTGCCATCTCTGTCTTGTTT	0.458000													39	167					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214417	140214417	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr5:140214417C>G	ENST00000525929.1	+	1	449	c.449C>G	c.(448-450)tCt>tGt	p.S150C	PCDHA7_ENST00000378125.3_Missense_Mutation_p.S150C|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTTGACTCTCGGTTTCCA	0.552000													3	33					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142178249	142178249	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:142178249C>G	ENST00000519811.1	+	13	1970	c.1900C>G	c.(1900-1902)Ctg>Gtg	p.L634V	DENND3_ENST00000424248.1_Missense_Mutation_p.L502V|DENND3_ENST00000262585.2_Missense_Mutation_p.L554V			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	554										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CGATAACTCTCTGCTCCTGGC	0.542000													93	168					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168430272	168430272	+	Missense_Mutation	SNP	T	T	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:168430272T>A	ENST00000443060.2	+	3	398	c.7T>A	c.(7-9)Tgg>Agg	p.W3R	KIF25_ENST00000351261.3_Missense_Mutation_p.W3R|KIF25_ENST00000354419.2_Missense_Mutation_p.W3R			Q9UIL4	KIF25_HUMAN	kinesin family member 25	3	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.W3R(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CCAGATGACATGGACCTCAGG	0.612000													4	92					0	0	1	0	0
LIN7B	64130	broad.mit.edu	37	19	49618206	49618206	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:49618206C>G	ENST00000221459.2	+	2	182	c.138C>G	c.(136-138)ttC>ttG	p.F46L	LIN7B_ENST00000391864.3_Missense_Mutation_p.F46L	NM_022165.2	NP_071448.1	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B (C. elegans)	46	L27.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		AGAGCCGCTTCTGCTCCGCTA	0.721000													4	8					0	0	1	0	0
RNASE1	6035	broad.mit.edu	37	14	21269841	21269841	+	Silent	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr14:21269841C>T	ENST00000397967.4	-	2	893	c.387G>A	c.(385-387)ccG>ccA	p.P129P	RNASE1_ENST00000412779.2_Silent_p.P129P|RNASE1_ENST00000340900.3_Silent_p.P129P|RNASE1_ENST00000397970.4_Silent_p.P129P|RNASE1_ENST00000555698.1_Silent_p.P89P	NM_002933.4	NP_002924.1	P07998	RNAS1_HUMAN	ribonuclease, RNase A family, 1 (pancreatic)	129						extracellular region	nucleic acid binding|pancreatic ribonuclease activity|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5	all_cancers(95;0.00671)	all_lung(585;0.235)	Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)		GTCTCTCCTTCGGGCTGGTCC	0.562000													29	63					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88446862	88446862	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr10:88446862G>A	ENST00000429277.2	+	6	871	c.726G>A	c.(724-726)ctG>ctA	p.L242L	LDB3_ENST00000352360.5_Intron|LDB3_ENST00000458213.2_Silent_p.L127L|LDB3_ENST00000542786.1_3'UTR|LDB3_ENST00000361373.4_Intron|LDB3_ENST00000263066.6_Silent_p.L127L|LDB3_ENST00000310944.6_Intron|LDB3_ENST00000372066.3_Silent_p.L127L|LDB3_ENST00000372056.4_Silent_p.L242L	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	234						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						CCAGTGCCCTGAAGGACTCGG	0.642000													69	179					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323733	44323733	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr21:44323733C>T	ENST00000354250.2	+	3	680	c.611C>T	c.(610-612)tCa>tTa	p.S204L	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	35					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	GTTACAGTATCAGCAAAAGAG	0.527000													11	57					0	0	1	0	0
CSNK1G1	53944	broad.mit.edu	37	15	64506298	64506298	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr15:64506298G>A	ENST00000303052.7	-	6	893	c.470C>T	c.(469-471)tCa>tTa	p.S157L	CSNK1G1_ENST00000303032.6_Missense_Mutation_p.S157L|CTD-2116N17.1_ENST00000606793.1_Missense_Mutation_p.S139L|CSNK1G1_ENST00000607537.1_Missense_Mutation_p.S157L	NM_022048.3	NP_071331.2	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	157	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	13						GAGGTTCTTTGAGTGCACGTA	0.373000													31	118					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823512	70823512	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:70823512G>A	ENST00000373695.1	+	7	922	c.385G>A	c.(385-387)Gac>Aac	p.D129N	ACRC_ENST00000373696.3_Missense_Mutation_p.D129N			Q96QF7	ACRC_HUMAN	acidic repeat containing	129	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					TGATGACAATGACGATGACAA	0.448000													54	181					0	0	1	0	0
GALK1	2584	broad.mit.edu	37	17	73754172	73754172	+	Missense_Mutation	SNP	G	G	C	rs111033608		TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:73754172G>C	ENST00000588479.1	-	8	1718	c.1144C>G	c.(1144-1146)Caa>Gaa	p.Q382E	GALK1_ENST00000225614.2_Missense_Mutation_p.Q382E|GALK1_ENST00000437911.1_Missense_Mutation_p.Q412E			P51570	GALK1_HUMAN	galactokinase 1	382					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	5	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCGGCTGCTTGAGAGAGGTAG	0.692000													19	54					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902371	51902371	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:51902371G>C	ENST00000268919.4	+	1	2133	c.1977G>C	c.(1975-1977)ctG>ctC	p.L659L		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	659					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AAAAGAAACTGAAATTATTAC	0.458000													11	42					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65273045	65273045	+	RNA	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr11:65273045C>G	ENST00000534336.1	+	0	7813					NR_002819.2																						CACCCCGTGCCTTTTGATCTA	0.532000													29	138					0	0	1	0	0
ZNF544	27300	broad.mit.edu	37	19	58773458	58773458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:58773458C>T	ENST00000269829.4	+	7	1960	c.1486C>T	c.(1486-1488)Cag>Tag	p.Q496*	ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000599953.1_Nonsense_Mutation_p.Q354*|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000600044.1_Nonsense_Mutation_p.Q468*|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000600220.1_Nonsense_Mutation_p.Q468*|ZNF544_ENST00000595981.1_Intron|ZNF544_ENST00000415203.2_Nonsense_Mutation_p.Q468*|ZNF544_ENST00000596825.1_3'UTR|CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000596652.1_Nonsense_Mutation_p.Q496*	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	496					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		CAAATGTACTCAGTGTGGGAA	0.448000													33	66					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084746	31084746	+	Missense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:31084746G>A	ENST00000376288.2	-	2	672	c.646C>T	c.(646-648)Cgt>Tgt	p.R216C	PSORS1C1_ENST00000467107.1_3'UTR|PSORS1C1_ENST00000259881.9_Intron	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	216	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						CTACAGGGACGCTGGTTGGAG	0.607000													26	126					0	0	1	0	0
XRCC1	7515	broad.mit.edu	37	19	44051123	44051123	+	Silent	SNP	G	G	C			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:44051123G>C	ENST00000262887.5	-	11	1753	c.1206C>G	c.(1204-1206)ctC>ctG	p.L402L	XRCC1_ENST00000543982.1_Silent_p.L371L			P18887	XRCC1_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 1	402	BRCT 1.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				GCCCTGCCATGAGGTACCTAG	0.582000								Other BER factors					14	40					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6183092	6183092	+	Silent	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:6183092C>G	ENST00000588304.1	+	10	1427	c.981C>G	c.(979-981)ctC>ctG	p.L327L	ACSBG2_ENST00000586696.1_Silent_p.L377L|ACSBG2_ENST00000252669.5_Silent_p.L377L|ACSBG2_ENST00000591403.1_Silent_p.L377L|ACSBG2_ENST00000588485.1_Silent_p.L190L|ACSBG2_ENST00000591741.1_3'UTR			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	377					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTAAGACTCTCGTGTTCAGCA	0.498000													25	93					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473386	50473386	+	RNA	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:50473386C>T	ENST00000602139.1	+	0	387									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						GTACTTCTTTCGGGTGGAGAG	0.552000													11	20					0	0	1	0	0
PPP1R9B	84687	broad.mit.edu	37	17	48217463	48217463	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:48217463C>T	ENST00000316878.6	-	7	1857	c.1855G>A	c.(1855-1857)Gag>Aag	p.E619K	PPP1R9B_ENST00000501501.2_5'UTR|AC002401.1_ENST00000451776.1_RNA	NM_032595.3	NP_115984.3	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	619	Interacts with TGN38 (By similarity).				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8						CCTACCTCCTCGTCATCCTCC	0.597000											OREG0024556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	17					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35210967	35210967	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr6:35210967G>A	ENST00000274938.7	+	15	1863	c.1863G>A	c.(1861-1863)ccG>ccA	p.P621P	SCUBE3_ENST00000394681.1_Silent_p.P637P	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	621					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						GAGCAGAGCCGATGGAGTCCT	0.627000													23	78					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100533109	100533109	+	Splice_Site	SNP	A	A	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chrX:100533109A>T	ENST00000372907.3	-	8	774	c.762_splice	c.e8-1	p.Y255_splice	TAF7L_ENST00000372905.2_Splice_Site_p.Y169_splice|TAF7L_ENST00000324762.6_Splice_Site_p.Y169_splice|TAF7L_ENST00000356784.1_Splice_Site_p.Y169_splice	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	255					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GATTCAATGTACTGAAGCAAA	0.433000													5	78					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518581	113518581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:113518581G>A	ENST00000284601.3	-	4	2634	c.2566C>T	c.(2566-2568)Caa>Taa	p.Q856*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	856					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GTTGCTTTTTGATATTCTGTA	0.373000													25	116					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79808376	79808376	+	Missense_Mutation	SNP	C	C	G			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr4:79808376C>G	ENST00000335016.5	+	15	2166	c.2000C>G	c.(1999-2001)tCt>tGt	p.S667C	PAQR3_ENST00000295462.3_3'UTR	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	667						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						GACTCACTTTCTGCTCCACAT	0.358000													4	26					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2161870	2161870	+	Missense_Mutation	SNP	C	C	T			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:2161870C>T	ENST00000262304.4	-	15	3506	c.3298G>A	c.(3298-3300)Gag>Aag	p.E1100K	PKD1_ENST00000423118.1_Missense_Mutation_p.E1100K	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1100	PKD 5.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGGAGGTACTCACCTGTGGGG	0.706000													7	29					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131817925	131817925	+	Silent	SNP	G	G	A			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:131817925G>A	ENST00000359827.3	-	31	6434	c.5472C>T	c.(5470-5472)atC>atT	p.I1824I	PLXNA4_ENST00000321063.4_Silent_p.I1824I			Q9HCM2	PLXA4_HUMAN	plexin A4	1824						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CTTGGTCGCTGATGGCTGGCA	0.507000													30	124					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2560819	2560821	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:2560819_2560821delCAG	ENST00000288709.6	-	2	316_318	c.76_78delCTG	c.(76-78)del	p.L26del	MMEL1_ENST00000502556.1_In_Frame_Del_p.L35del|MMEL1_ENST00000378412.3_In_Frame_Del_p.L35del	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	35					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGCGGTCACcagcagcagcagc	0.739													3	5	---	---	---	---					
PLEKHM2	23207	broad.mit.edu	37	1	16042801	16042801	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr1:16042801delC	ENST00000375799.3	+	2	357	c.130delC	c.(130-132)gtfs	p.R44fs	PLEKHM2_ENST00000375793.2_Frame_Shift_Del_p.R44fs	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	44	Interaction with KIF5B.|RUN.				Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GGTCCTACAGCGTCTGTGTGA	0.517													5	10	---	---	---	---					
BAP1	8314	broad.mit.edu	37	3	52437500	52437500	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr3:52437500delC	ENST00000460680.1	-	13	2132	c.1661delG	c.(1660-1662)gtfs	p.G554fs	BAP1_ENST00000296288.5_Frame_Shift_Del_p.G536fs	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	554					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GATGACAGGACCCAGATCACG	0.607			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							77	32	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149526953	149526953	+	RNA	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr7:149526953delC	ENST00000378016.2	+	0	15142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			cctcctgtgtcccccccacag	0.667													2	4	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142444250	142444254	+	RNA	DEL	TGGGT	TGGGT	-	rs28372340	by1000genomes	TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr8:142444250_142444254delTGGGT	ENST00000430863.1	-	0	3937					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGGGGTGGGGTGGGTGGTGGGTGGG	0.654													3	4	---	---	---	---					
ZNF598	90850	broad.mit.edu	37	16	2049882	2049883	+	In_Frame_Ins	INS	-	-	TCC	rs61746014	by1000genomes	TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:2049882_2049883insTCC	ENST00000563630.1	-	9	1744_1745	c.1502_1503insGGA	c.(1501-1503)ggg>gGGAgg	p.501_502insR	ZNF598_ENST00000431526.1_In_Frame_Ins_p.556_557insR|ZNF598_ENST00000562103.1_In_Frame_Ins_p.501_502insR			Q86UK7	ZN598_HUMAN	zinc finger protein 598	556						intracellular	zinc ion binding	p.E555_D556insE(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CCGGGCCGCCGTCCTCCTCCTC	0.703													6	5	---	---	---	---					
WWP2	11060	broad.mit.edu	37	16	69833132	69833132	+	Frame_Shift_Del	DEL	A	A	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr16:69833132delA	ENST00000359154.2	+	4	375	c.274delA	c.(274-276)gafs	p.R92fs	WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Frame_Shift_Del_p.R92fs|WWP2_ENST00000569174.1_Frame_Shift_Del_p.R92fs|WWP2_ENST00000356003.2_Frame_Shift_Del_p.R92fs	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	92	C2.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCATACCTTGAGAAATGAACT	0.453											OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	71	---	---	---	---					
IFI35	3430	broad.mit.edu	37	17	41164281	41164281	+	Frame_Shift_Del	DEL	C	C	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr17:41164281delC	ENST00000415816.2	+	2	330	c.107delC	c.(106-108)tcfs	p.S36fs	IFI35_ENST00000536969.1_3'UTR|IFI35_ENST00000438323.2_Frame_Shift_Del_p.S36fs	NM_005533.4	NP_005524.2	P80217	IN35_HUMAN	interferon-induced protein 35	36					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		CTCGGGGACTCCCCCAAAGAC	0.597													2	4	---	---	---	---					
CNDP2	55748	broad.mit.edu	37	18	72167216	72167221	+	In_Frame_Del	DEL	CCCTCA	CCCTCA	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr18:72167216_72167221delCCCTCA	ENST00000324262.4	+	2	324_329	c.8_13delCCCTCA	c.(7-15)gct>g	p.ALT3del	CNDP2_ENST00000324301.8_In_Frame_Del_p.ALT3del|CNDP2_ENST00000579847.1_In_Frame_Del_p.ALT3del	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	3						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AAGATGGCGGCCCTCACTACCCTGTT	0.466													12	62	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42880807	42880808	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-95-7948-01A-11D-2184-08	TCGA-95-7948-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab3b50c5-0335-4685-acc2-eeadbf2a9c1b	984543c0-0d4b-4b68-997e-a8e3a755414d	g.chr19:42880807_42880808delGC	ENST00000334370.4	+	41	8852_8853	c.8217_8218delGC	c.(8215-8220)ctggfs	p.LR2739fs	MEGF8_ENST00000378073.4_Frame_Shift_Del_p.LR400fs|MEGF8_ENST00000251268.6_Frame_Shift_Del_p.LR2806fs	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2806	Gly-rich.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TCGTCACACTGCGGCACAGGCT	0.688													3	5	---	---	---	---					
