Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR107	57720	broad.mit.edu	37	9	132863393	132863393	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:132863393G>A	ENST00000372406.1	+	12	1529	c.1022G>A	c.(1021-1023)gGg>gAg	p.G341E	GPR107_ENST00000372410.3_Missense_Mutation_p.G341E|GPR107_ENST00000347136.6_Missense_Mutation_p.G341E	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	341						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				AGTTTGAAAGGGGCGCTACTC	0.428000													30	67					0	0	0.717897	0	0
RNF182	221687	broad.mit.edu	37	6	13977460	13977460	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:13977460T>G	ENST00000488300.1	+	3	633	c.110T>G	c.(109-111)cTg>cGg	p.L37R	RNF182_ENST00000537388.1_Missense_Mutation_p.L37R|RNF182_ENST00000544682.1_Missense_Mutation_p.L37R|RNF182_ENST00000537663.1_Missense_Mutation_p.L37R	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	37						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CCCAAAGTGCTGGAGTGTTGT	0.478000													40	99					0	0	0.804634	0	0
LMLN	89782	broad.mit.edu	37	3	197687280	197687280	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:197687280C>T	ENST00000330198.4	+	1	210	c.188C>T	c.(187-189)cCc>cTc	p.P63L	LMLN_ENST00000420910.2_Missense_Mutation_p.P63L|LMLN_ENST00000332636.5_Intron|LMLN_ENST00000482695.1_Intron	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	63					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		AGTTCCCCTCCCTGCCGGCAC	0.657000													36	51					0	0	0.804634	0	0
LOC102546299	102546299	broad.mit.edu	37	5	164028186	164028186	+	RNA	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:164028186G>T	ENST00000486913.3	+	0	364				CTC-340A15.2_ENST00000523704.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000517508.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA																							CACCATCTTGGGAGGGATGAT	0.592000													5	17					0.0215528	0.0225566	0.217242	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51914473	51914473	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:51914473G>T	ENST00000353836.5	-	10	1910	c.1689C>A	c.(1687-1689)tcC>tcA	p.S563S	SIGLEC10_ENST00000442846.3_Silent_p.S415S|SIGLEC10_ENST00000441969.3_Silent_p.S505S|SIGLEC10_ENST00000432469.2_Silent_p.S480S|SIGLEC10_ENST00000339313.5_Silent_p.S658S|SIGLEC10_ENST00000525998.1_Silent_p.S473S|SIGLEC10_ENST00000356298.5_Silent_p.S658S|SIGLEC10_ENST00000439889.2_Silent_p.S600S|SIGLEC10_ENST00000436984.2_Silent_p.S515S	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	658					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGCTCTCCTGGGATTCTGGGG	0.567000													46	119					1.32667e-27	2.55954e-27	0.870114	1	0
SH3RF2	153769	broad.mit.edu	37	5	145435760	145435760	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:145435760G>T	ENST00000511217.1	+	7	1591	c.1539G>T	c.(1537-1539)cgG>cgT	p.R513R	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.R513R			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	513							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGAAAGGGCGGAGCAGCATGA	0.547000													28	47					1.17739e-12	1.9555e-12	0.693898	1	0
IL9R	3581	broad.mit.edu	37	X	155233457	155233457	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:155233457C>G	ENST00000424344.3	+	5	674	c.307C>G	c.(307-309)Cac>Gac	p.H103D	IL9R_ENST00000540897.1_Silent_p.T158T|IL9R_ENST00000369423.2_Silent_p.T168T|IL9R_ENST00000244174.5_Missense_Mutation_p.H124D			Q01113	IL9R_HUMAN	interleukin 9 receptor	124					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CACTTTCCACCACTGCATGTC	0.622000													12	44					0	0	0.387290	0	0
EPHA3	2042	broad.mit.edu	37	3	89448476	89448476	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:89448476A>T	ENST00000336596.2	+	7	1665	c.1440A>T	c.(1438-1440)caA>caT	p.Q480H	EPHA3_ENST00000494014.1_Missense_Mutation_p.Q480H|EPHA3_ENST00000452448.2_Missense_Mutation_p.Q480H	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	480	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding	p.Q480Q(2)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AGCAGGAACAAGAAACAAGTT	0.368000										TSP Lung(6;0.00050)			15	38					0	0	0.520397	0	0
NPAS3	64067	broad.mit.edu	37	14	34269356	34269356	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:34269356C>A	ENST00000346562.2	+	11	1821	c.1747C>A	c.(1747-1749)Cgg>Agg	p.R583R	NPAS3_ENST00000357798.5_Silent_p.R602R|NPAS3_ENST00000551492.1_Silent_p.R620R|NPAS3_ENST00000548645.1_Silent_p.R585R|NPAS3_ENST00000356141.4_Silent_p.R615R	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.R602G(1)|p.R583G(1)|p.R615G(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGCCAGCCGCCGGCGCCTGTC	0.721000													12	47					0.010729	0.0112906	0.387290	1	0
BCOR	54880	broad.mit.edu	37	X	39921532	39921532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:39921532G>A	ENST00000342274.4	-	10	4548	c.4186C>T	c.(4186-4188)Cag>Tag	p.Q1396*	BCOR_ENST00000378463.1_Nonsense_Mutation_p.Q273*|BCOR_ENST00000397354.3_Nonsense_Mutation_p.Q1396*|BCOR_ENST00000378444.4_Nonsense_Mutation_p.Q1430*|BCOR_ENST00000378455.4_Nonsense_Mutation_p.Q1378*	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1430					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						TGTGTGGACTGGGAGGCTGGT	0.582000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						6	19					0	0	0.248553	0	0
GPAM	57678	broad.mit.edu	37	10	113933468	113933468	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:113933468C>A	ENST00000348367.4	-	7	746	c.549G>T	c.(547-549)ccG>ccT	p.P183P	GPAM_ENST00000423155.1_Silent_p.P183P|GPAM_ENST00000369425.1_Silent_p.P183P			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	183					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TGATCATTGCCGGTGAGACAG	0.403000													14	52					1.49906e-05	1.82952e-05	0.457914	1	0
CABP1	9478	broad.mit.edu	37	12	121093916	121093916	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:121093916C>A	ENST00000453000.1	+	1	815	c.303C>A	c.(301-303)acC>acA	p.T101T	CABP1_ENST00000316803.3_Intron|CABP1_ENST00000351200.2_Intron|CABP1_ENST00000288616.3_Silent_p.T22T			Q9NZU7	CABP1_HUMAN	calcium binding protein 1	0	Pro-rich.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGGAACAGACCAGCTACATGG	0.647000													5	31					0.184627	0.187076	0.184627	1	0
TUBB8	347688	broad.mit.edu	37	10	94813	94813	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:94813C>A	ENST00000309812.4	-	2	159	c.97G>T	c.(97-99)Gct>Tct	p.A33S	TUBB8_ENST00000332708.5_Intron|TUBB8_ENST00000447903.2_5'UTR|TUBB8_ENST00000413237.3_5'UTR	NM_177987.2	NP_817124.1	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	33					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TAGGTGCCAGCGGAGTCGATG	0.652000													4	6					0.00024832	0.00028486	0.150653	1	0
POTEG	404785	broad.mit.edu	37	14	19553564	19553564	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:19553564G>C	ENST00000409832.3	+	1	200	c.148G>C	c.(148-150)Gac>Cac	p.D50H		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	50										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						TGGAGACCACGACGATTCTGC	0.607000													26	392					0	0	0.769981	0	0
POTED	317754	broad.mit.edu	37	21	15013714	15013714	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:15013714G>T	ENST00000299443.5	+	11	1634	c.1582G>T	c.(1582-1584)Gtg>Ttg	p.V528L		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	528						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						TGAAAACAGCGTGTTGCAGGA	0.353000													17	11					5.3912e-06	6.79683e-06	0.539581	1	0
PTPRD	5789	broad.mit.edu	37	9	8521338	8521338	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:8521338G>T	ENST00000381196.4	-	17	1443	c.900C>A	c.(898-900)taC>taA	p.Y300*	PTPRD_ENST00000540109.1_Nonsense_Mutation_p.Y300*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.Y297*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.Y300*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.Y297*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.Y290*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.Y290*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.Y300*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.Y287*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.Y300*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.Y287*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	300	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CAACACAGGTGTAATTTGCTG	0.423000										TSP Lung(15;0.13)			10	50					3.07112e-06	3.91056e-06	0.387290	1	0
CACNA1C	775	broad.mit.edu	37	12	2614017	2614017	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:2614017G>A	ENST00000399655.1	+	8	1388	c.1123G>A	c.(1123-1125)Gcc>Acc	p.A375T	CACNA1C_ENST00000399621.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399629.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000399637.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000347598.4_Missense_Mutation_p.A375T|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A375T|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A375T|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A375T|CACNA1C_ENST00000399644.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A375T|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A375T|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399617.1_Intron	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	375					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTCAATGATGCCGTAGGAAG	0.522000													3	18					0	0	0.115264	0	0
MTMR1	8776	broad.mit.edu	37	X	149901131	149901131	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:149901131G>C	ENST00000445323.2	+	10	1130	c.1009G>C	c.(1009-1011)Gat>Cat	p.D337H	MTMR1_ENST00000538506.1_Missense_Mutation_p.D216H|MTMR1_ENST00000451863.2_Missense_Mutation_p.D329H|MTMR1_ENST00000370390.3_Missense_Mutation_p.D329H|MTMR1_ENST00000542156.1_Missense_Mutation_p.D329H|MTMR1_ENST00000541925.1_Missense_Mutation_p.D235H|MTMR1_ENST00000544228.1_Missense_Mutation_p.D329H			Q13613	MTMR1_HUMAN	myotubularin related protein 1	329	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AACAATAATGGATGCTAACGC	0.438000													15	36					0	0	0.457914	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235629009	235629009	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:235629009T>A	ENST00000366600.3	-	7	1013	c.785A>T	c.(784-786)cAt>cTt	p.H262L	B3GALNT2_ENST00000313984.3_Missense_Mutation_p.H303L|B3GALNT2_ENST00000478199.1_5'UTR	NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	262					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			CAAGAATTCATGAGGCAATGC	0.358000													4	90					0	0	0.184627	0	0
GRM5	2915	broad.mit.edu	37	11	88300451	88300451	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:88300451G>T	ENST00000418177.2	-	8	2767	c.2400C>A	c.(2398-2400)atC>atA	p.I800I	GRM5_ENST00000393297.1_Silent_p.I800I|GRM5_ENST00000305447.4_Silent_p.I800I|GRM5_ENST00000455756.2_Silent_p.I800I|GRM5_ENST00000305432.5_Silent_p.I800I			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	800					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AACACATGGTGATGATTTTGT	0.488000													25	52					1.64293e-13	2.81435e-13	0.654019	1	0
SLC9A6	10479	broad.mit.edu	37	X	135067901	135067901	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:135067901G>T	ENST00000370695.4	+	1	275	c.240G>T	c.(238-240)ctG>ctT	p.L80L	SLC9A6_ENST00000370701.1_Silent_p.L28L|SLC9A6_ENST00000370698.3_Silent_p.L80L	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	80					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TCATCCTGCTGCTCACCCTCA	0.597000													38	167					2.05212e-20	3.84269e-20	0.812448	1	0
ITGA2	3673	broad.mit.edu	37	5	52356839	52356839	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:52356839G>T	ENST00000296585.5	+	12	1564	c.1421G>T	c.(1420-1422)gGc>gTc	p.G474V		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	474					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AATGAGAATGGCAATATCACG	0.473000													27	57					1.06801e-11	1.70703e-11	0.740014	1	0
LMX1A	4009	broad.mit.edu	37	1	165179965	165179965	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:165179965G>A	ENST00000342310.3	-	6	1100	c.718C>T	c.(718-720)Cag>Tag	p.Q240*	LMX1A_ENST00000294816.2_Nonsense_Mutation_p.Q240*|LMX1A_ENST00000367893.4_Nonsense_Mutation_p.Q240*|RP11-38C18.2_ENST00000457106.1_RNA|LMX1A_ENST00000489443.2_5'UTR	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	240	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					AACCACACCTGGACGACACGG	0.478000													10	31					0	0	0.361761	0	0
PXDNL	137902	broad.mit.edu	37	8	52320868	52320868	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:52320868C>A	ENST00000356297.4	-	17	3416	c.3316G>T	c.(3316-3318)Ggc>Tgc	p.G1106C	PXDNL_ENST00000543296.1_Missense_Mutation_p.G1106C	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1106					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCAGCCACGCCAAACAGCCCC	0.572000													8	86					0.00829132	0.00882252	0.361761	1	0
OR4C16	219428	broad.mit.edu	37	11	55340160	55340160	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:55340160C>G	ENST00000314634.3	+	1	557	c.557C>G	c.(556-558)gCc>gGc	p.A186G		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TTGAAACAAGCCTGTTCAGAA	0.428000													21	74					0	0	0.592651	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740199	37740199	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:37740199G>T	ENST00000539465.1	+	15	2267	c.1674G>T	c.(1672-1674)caG>caT	p.Q558H	FRMPD1_ENST00000377765.3_Missense_Mutation_p.Q558H|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.Q380H|FRMPD1_ENST00000541302.1_Missense_Mutation_p.Q427H			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	558						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AGGAGGAGCAGCCTCCTGGGA	0.632000													30	50					1.68575e-08	2.35021e-08	0.717897	1	0
TAGAP	117289	broad.mit.edu	37	6	159457971	159457971	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:159457971C>A	ENST00000367066.3	-	10	1415	c.1084G>T	c.(1084-1086)Gtg>Ttg	p.V362L	TAGAP_ENST00000326965.6_Missense_Mutation_p.V184L|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	362					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AGCCTGGCCACGGTGCTCACA	0.647000													12	61					0.000978159	0.00109577	0.387290	1	0
PDE10A	10846	broad.mit.edu	37	6	165801872	165801872	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:165801872T>C	ENST00000366882.1	-	18	1851	c.1697A>G	c.(1696-1698)cAg>cGg	p.Q566R	PDE10A_ENST00000539869.2_Missense_Mutation_p.Q576R|PDE10A_ENST00000354448.4_Missense_Mutation_p.Q566R			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	566					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTCGAACTTCTGCAGGTAGCT	0.527000													18	62					0	0	0.539581	0	0
KIF1A	547	broad.mit.edu	37	2	241683359	241683359	+	Splice_Site	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:241683359C>A	ENST00000498729.2	-	33	3830	c.3584_splice	c.e33+1	p.S1195_splice	KIF1A_ENST00000320389.7_Splice_Site_p.S1094_splice	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1094					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGGCGCTAACCTGAGCACGTC	0.592000													30	88					1.13719e-10	1.72384e-10	0.729181	1	0
TIAM1	7074	broad.mit.edu	37	21	32537381	32537381	+	Splice_Site	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:32537381C>G	ENST00000286827.3	-	17	3360	c.2887_splice	c.e17-1	p.G963_splice	TIAM1_ENST00000541036.1_Splice_Site_p.G903_splice	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	963					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AAAGGCTGTGCCCTGTCAGAT	0.537000													12	33					0	0	0.411799	0	0
NRXN2	9379	broad.mit.edu	37	11	64434943	64434943	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:64434943G>T	ENST00000265459.6	-	9	2038	c.1577C>A	c.(1576-1578)cCc>cAc	p.P526H	NRXN2_ENST00000409571.1_Missense_Mutation_p.P519H|NRXN2_ENST00000377551.1_Missense_Mutation_p.P526H|NRXN2_ENST00000377559.3_Missense_Mutation_p.P495H	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	526	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CAGCCCATTGGGCTCGGTGGT	0.657000													22	56					2.37509e-13	4.05038e-13	0.592651	1	0
CDH23	64072	broad.mit.edu	37	10	73377139	73377139	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:73377139G>T	ENST00000224721.6	+	10	1143	c.1138G>T	c.(1138-1140)Gac>Tac	p.D380Y	CDH23_ENST00000461841.3_Missense_Mutation_p.D420Y|CDH23_ENST00000398809.4_Missense_Mutation_p.D375Y|CDH23_ENST00000398842.3_Missense_Mutation_p.D375Y|CDH23_ENST00000299366.7_Missense_Mutation_p.D420Y	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	375	Cadherin 4.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCAGGTGGTGGACAAGGATGA	0.582000													8	20					0.0381472	0.0395985	0.278610	1	0
GK	2710	broad.mit.edu	37	X	30738765	30738765	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:30738765G>A	ENST00000378943.3	+	16	1425	c.1246G>A	c.(1246-1248)Gga>Aga	p.G416R	GK-AS1_ENST00000464659.1_RNA|GK_ENST00000378945.3_Missense_Mutation_p.G416R|GK_ENST00000378946.3_Missense_Mutation_p.G422R|RP11-242C19.2_ENST00000497961.1_RNA|GK_ENST00000427190.1_Missense_Mutation_p.G217R	NM_001128127.2	NP_001121599.1	P32189	GLPK_HUMAN	glycerol kinase	422					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)|large_intestine(3)	4						TCGAGACTGTGGAATTCCACT	0.368000													15	62					0	0	0.500413	0	0
BFSP1	631	broad.mit.edu	37	20	17474970	17474970	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:17474970G>T	ENST00000377873.3	-	8	1786	c.1747C>A	c.(1747-1749)Cca>Aca	p.P583T	BFSP1_ENST00000536626.1_Missense_Mutation_p.P444T|BFSP1_ENST00000544874.1_Missense_Mutation_p.P444T|BFSP1_ENST00000377868.2_Missense_Mutation_p.P458T	NM_001195.3	NP_001186.1	Q12934	BFSP1_HUMAN	beaded filament structural protein 1, filensin	583	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)|stomach(1)	18						GGTATAGATGGTTCCTCTGCA	0.597000													6	173					0.00198382	0.00215289	0.248553	1	0
PKD1	5310	broad.mit.edu	37	16	2164249	2164249	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:2164249C>A	ENST00000262304.4	-	11	2983	c.2775G>T	c.(2773-2775)cgG>cgT	p.R925R	PKD1_ENST00000423118.1_Silent_p.R925R	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	925	PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCGCCGTCACCCGCAGGCTGA	0.682000													5	45					1.23904e-05	1.52682e-05	0.184627	1	0
NSMAF	8439	broad.mit.edu	37	8	59508123	59508123	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:59508123T>C	ENST00000038176.3	-	22	2100	c.1888A>G	c.(1888-1890)Aaa>Gaa	p.K630E	NSMAF_ENST00000427130.2_Missense_Mutation_p.K661E	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	630					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				TCTTACTCTTTGTGGATTTTA	0.428000													8	24					0	0	0.361761	0	0
NALCN	259232	broad.mit.edu	37	13	101726011	101726011	+	Silent	SNP	C	C	A	rs139869457		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr13:101726011C>A	ENST00000251127.6	-	37	4203	c.4122G>T	c.(4120-4122)tcG>tcT	p.S1374S		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1374						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTTTCCAGCCGAAGAAAAAT	0.353000													6	28					0.00198382	0.00215289	0.248553	1	0
ABCC5	10057	broad.mit.edu	37	3	183700641	183700641	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:183700641C>A	ENST00000334444.6	-	6	986	c.746G>T	c.(745-747)cGc>cTc	p.R249L	ABCC5_ENST00000265586.6_Missense_Mutation_p.R249L|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	249	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCCGCAAGCGGACACCGGT	0.507000													20	56					1.28384e-07	1.70287e-07	0.608945	1	0
P2RY10	27334	broad.mit.edu	37	X	78216382	78216382	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:78216382G>A	ENST00000171757.2	+	4	645	c.365G>A	c.(364-366)tGt>tAt	p.C122Y	P2RY10_ENST00000475374.1_3'UTR|P2RY10_ENST00000544091.1_Missense_Mutation_p.C122Y	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	122						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						GCCAGCATTTGTTTCCTGACG	0.507000													49	122					0	0	0.870114	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928865	32928865	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:32928865G>T	ENST00000361627.3	+	12	2613	c.1891G>T	c.(1891-1893)Gaa>Taa	p.E631*	ARHGAP11A_ENST00000543522.1_Nonsense_Mutation_p.E442*|ARHGAP11A_ENST00000565905.1_Nonsense_Mutation_p.E442*	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	631					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		AAAATTAACTGAACCATCTTA	0.343000													15	23					1.05317e-09	1.51816e-09	0.457914	1	0
CCL7	6354	broad.mit.edu	37	17	32598209	32598209	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:32598209A>C	ENST00000378569.2	+	2	191	c.121A>C	c.(121-123)Aag>Cag	p.K41Q	CCL7_ENST00000394627.1_Silent_p.I58I|CCL7_ENST00000200307.4_Missense_Mutation_p.K51Q|CCL7_ENST00000394630.3_Intron	NM_006273.2	NP_006264.2	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7	41					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		ATTTATCAATAAGAAAATCCC	0.473000													32	50					0	0	0.729181	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106849452	106849452	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:106849452T>A	ENST00000526355.1	-	3	848	c.380A>T	c.(379-381)gAa>gTa	p.E127V	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.E127V|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.E127V	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	127					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GAAATTCTTTTCTGCATCCCT	0.378000													5	14					0	0	0.217242	0	0
MGAM	8972	broad.mit.edu	37	7	141726932	141726932	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:141726932G>T	ENST00000475668.2	+	9	1054	c.1000G>T	c.(1000-1002)Gcg>Tcg	p.A334S	MGAM_ENST00000549489.2_Missense_Mutation_p.A334S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	334	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTTCAGCCTGCGCCAGCCAT	0.383000													24	87					7.33532e-06	9.21741e-06	0.667858	1	0
SCN8A	6334	broad.mit.edu	37	12	52162673	52162673	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:52162673C>T	ENST00000354534.5	+	17	3104	c.2926C>T	c.(2926-2928)Ctc>Ttc	p.L976F	SCN8A_ENST00000545061.1_Missense_Mutation_p.L976F	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	976					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCTGGCCTTGCTCCTGAGCTC	0.493000													6	36					0	0	0.217242	0	0
BEST3	144453	broad.mit.edu	37	12	70072571	70072571	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:70072571G>T	ENST00000330891.5	-	5	810	c.584C>A	c.(583-585)gCc>gAc	p.A195D	BEST3_ENST00000553096.1_Missense_Mutation_p.A89D|BEST3_ENST00000331471.4_Missense_Mutation_p.A195D|BEST3_ENST00000476098.1_Missense_Mutation_p.A33D|BEST3_ENST00000488961.1_Missense_Mutation_p.A33D	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	195						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TTCATTCCGGGCTTTAGTTGC	0.358000													4	33					0.00909568	0.0095982	0.150653	1	0
MYH11	4629	broad.mit.edu	37	16	15808797	15808797	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:15808797G>C	ENST00000338282.6	-	40	5861	c.5755C>G	c.(5755-5757)Cgc>Ggc	p.R1919G	NDE1_ENST00000396355.1_Intron|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000452625.2_Missense_Mutation_p.R1926G|MYH11_ENST00000576790.1_Missense_Mutation_p.R1919G|MYH11_ENST00000396324.3_Missense_Mutation_p.R1926G|MYH11_ENST00000300036.5_Missense_Mutation_p.R1919G|NDE1_ENST00000342673.5_Intron	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1919					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TTCACCTCGCGGCCCATGGCC	0.672000			T	CBFB	AML								101	101					0	0	0.870114	0	0
LRFN5	145581	broad.mit.edu	37	14	42356189	42356189	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:42356189G>A	ENST00000554171.1	+	5	2793	c.361G>A	c.(361-363)Ggt>Agt	p.G121S	LRFN5_ENST00000298119.4_Missense_Mutation_p.G121S|LRFN5_ENST00000554120.1_Missense_Mutation_p.G121S			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	121						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TATGTTCAGTGGTCTTTCCAA	0.378000										HNSCC(30;0.082)			14	73					0	0	0.435327	0	0
VAMP7	6845	broad.mit.edu	37	X	155171607	155171607	+	Nonsense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:155171607A>T	ENST00000286448.6	+	8	820	c.655A>T	c.(655-657)Aag>Tag	p.K219*	VAMP7_ENST00000262640.6_Missense_Mutation_p.E196V|VAMP7_ENST00000460621.1_Nonsense_Mutation_p.K178*	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	219					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AAGCTGTGTGAAGAAATAGGA	0.398000													4	32					0	0	0.150653	0	0
CT47B1	643311	broad.mit.edu	37	X	120008948	120008948	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:120008948C>A	ENST00000371311.3	-	1	831	c.577G>T	c.(577-579)Gct>Tct	p.A193S		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	193										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						ACCGACGCAGCCTCCTGGATC	0.706000													47	104					5.20006e-24	9.93212e-24	0.859065	1	0
LRRK1	79705	broad.mit.edu	37	15	101550913	101550913	+	Silent	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:101550913A>G	ENST00000284395.5	+	10	1543	c.1143A>G	c.(1141-1143)gaA>gaG	p.E381E	LRRK1_ENST00000388948.3_Silent_p.E384E			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	384					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGCTACAGGAACTTGATATAT	0.378000													4	41					0	0	0.150653	0	0
BAI3	577	broad.mit.edu	37	6	69666045	69666045	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:69666045C>T	ENST00000370598.1	+	7	2146	c.1325C>T	c.(1324-1326)gCa>gTa	p.A442V		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	442	TSP type-1 3.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.A442E(1)		NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GGGCCATGGGCAGAAAGCAGA	0.527000													3	25					0	0	0.115264	0	0
CACNA1I	8911	broad.mit.edu	37	22	40030681	40030681	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:40030681G>T	ENST00000336649.4	+	7	692	c.692G>T	c.(691-693)tGg>tTg	p.W231L	CACNA1I_ENST00000404898.1_Missense_Mutation_p.W231L|CACNA1I_ENST00000400164.3_Missense_Mutation_p.W231L|CACNA1I_ENST00000402142.3_Missense_Mutation_p.W231L|CACNA1I_ENST00000407673.1_Missense_Mutation_p.W231L|CACNA1I_ENST00000401624.1_Missense_Mutation_p.W231L			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	231					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GTGCAGCTCTGGGCGGGCCTG	0.567000													41	89					8.16277e-20	1.51368e-19	0.827153	1	0
CXorf40B	541578	broad.mit.edu	37	X	149101926	149101926	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:149101926A>G	ENST00000370406.3	-	4	995	c.167T>C	c.(166-168)cTg>cCg	p.L56P	CXorf40B_ENST00000355203.2_Missense_Mutation_p.L56P|CXorf40B_ENST00000370404.1_Missense_Mutation_p.L56P|CXorf40B_ENST00000462691.1_Missense_Mutation_p.L56P			Q96DE9	CX04B_HUMAN	chromosome X open reading frame 40B	56										endometrium(1)|lung(4)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCACCAGCAGCTCCCGACA	0.587000													35	152					0	0	0.769981	0	0
OBSCN	84033	broad.mit.edu	37	1	228509182	228509182	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:228509182G>T	ENST00000570156.2	+	66	17585	c.17511G>T	c.(17509-17511)caG>caT	p.Q5837H	OBSCN_ENST00000284548.11_Missense_Mutation_p.Q4880H|OBSCN_ENST00000366709.4_Missense_Mutation_p.Q1999H|OBSCN_ENST00000422127.1_Missense_Mutation_p.Q4880H|OBSCN_ENST00000366707.4_Missense_Mutation_p.Q2514H	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4880	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGAAGATCCAGGCTGCCTTTA	0.597000													7	20					0.00198382	0.00215289	0.248553	1	0
LZTS2	84445	broad.mit.edu	37	10	102762640	102762640	+	Silent	SNP	A	A	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:102762640A>C	ENST00000370220.1	+	1	3408	c.345A>C	c.(343-345)gcA>gcC	p.A115A	LZTS2_ENST00000370223.3_Silent_p.A115A			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	115	Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		AGCAGCGGGCACACAATGCCC	0.602000													14	71					0	0	0.479597	0	0
EPHA7	2045	broad.mit.edu	37	6	93967918	93967918	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:93967918C>A	ENST00000369303.4	-	11	2193	c.2009G>T	c.(2008-2010)gGt>gTt	p.G670V		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	670	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TTCTGTGTAACCAACTTTCAG	0.438000													37	78					1.414e-09	2.03063e-09	0.788014	1	0
NOTCH1	4851	broad.mit.edu	37	9	139409742	139409742	+	Splice_Site	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:139409742C>A	ENST00000277541.6	-	12	2089	c.2014_splice	c.e12+1	p.G672_splice		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	672	EGF-like 17; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCGCTCACCTGTGTAGCCC	0.637000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			20	35					8.04996e-18	1.45739e-17	0.608945	1	0
SATB2	23314	broad.mit.edu	37	2	200137283	200137283	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:200137283C>A	ENST00000443023.1	-	10	3141	c.1676G>T	c.(1675-1677)cGc>cTc	p.R559L	SATB2_ENST00000428695.1_Missense_Mutation_p.R500L|SATB2_ENST00000417098.1_Missense_Mutation_p.R618L|SATB2_ENST00000457245.1_Missense_Mutation_p.R618L|SATB2_ENST00000260926.5_Missense_Mutation_p.R618L			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	618						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GATCTTTGTGCGAGACCGGGG	0.562000													27	87					4.22769e-11	6.56496e-11	0.706142	1	0
RAPGEF1	2889	broad.mit.edu	37	9	134471745	134471745	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:134471745C>A	ENST00000372195.1	-	14	2365	c.2122G>T	c.(2122-2124)Gac>Tac	p.D708Y	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.D691Y|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.D709Y			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	691	N-terminal Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCGCGGACGTCCGGCCCGTCA	0.527000													11	30					9.31168e-06	1.16244e-05	0.435327	1	0
PELP1	27043	broad.mit.edu	37	17	4607241	4607241	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:4607241C>A	ENST00000301396.4	-	1	391	c.166G>T	c.(166-168)Gtg>Ttg	p.V56L	PELP1_ENST00000572293.1_Missense_Mutation_p.V106L|PELP1_ENST00000570823.1_5'UTR|PELP1_ENST00000436683.2_5'UTR|PELP1_ENST00000269230.7_Missense_Mutation_p.V56L|PELP1_ENST00000574876.1_Missense_Mutation_p.V56L			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	56					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						GGGGGATGCACCGGAGCAACG	0.687000													8	38					0.0477658	0.0494486	0.307466	1	0
DGKB	1607	broad.mit.edu	37	7	14647118	14647118	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:14647118G>T	ENST00000403951.2	-	17	1796	c.1377C>A	c.(1375-1377)ttC>ttA	p.F459L	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.F459L|DGKB_ENST00000406247.3_Missense_Mutation_p.F459L|DGKB_ENST00000402815.1_Missense_Mutation_p.F458L|DGKB_ENST00000407950.1_Missense_Mutation_p.F451L|DGKB_ENST00000444700.2_Missense_Mutation_p.F440L|DGKB_ENST00000399322.3_Missense_Mutation_p.F459L			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	459	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	ATAGATACTGGAATTTTCTGT	0.284000													7	18					0.000157383	0.000182183	0.278610	1	0
HELQ	113510	broad.mit.edu	37	4	84338004	84338004	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:84338004C>A	ENST00000295488.3	-	17	3240	c.3078G>T	c.(3076-3078)caG>caT	p.Q1026H	HELQ_ENST00000510985.1_Missense_Mutation_p.Q959H	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	1026							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CACTGTATAACTGTTTTGCTC	0.353000								Other identified genes with known or suspected DNA repair function					15	40					2.61681e-11	4.13067e-11	0.457914	1	0
WNT9B	7484	broad.mit.edu	37	17	44952705	44952705	+	Silent	SNP	C	C	T	rs142428656	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:44952705C>T	ENST00000393461.2	+	3	626	c.573C>T	c.(571-573)gaC>gaT	p.D191D	WNT9B_ENST00000290015.2_Silent_p.D191D			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	191					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CACGGGCAGACGCCCACAATA	0.607000													5	23					0	0	0.184627	0	0
GBE1	2632	broad.mit.edu	37	3	81698058	81698058	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:81698058C>A	ENST00000429644.2	-	5	1283	c.640G>T	c.(640-642)Gct>Tct	p.A214S	GBE1_ENST00000489715.1_Missense_Mutation_p.A173S	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	214					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TTATAAGAAGCTACTTTTCCT	0.318000									Glycogen Storage Disease, type IV				6	9					3.59834e-05	4.28213e-05	0.217242	1	0
HERC1	8925	broad.mit.edu	37	15	63991040	63991040	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:63991040A>C	ENST00000443617.2	-	26	4879	c.4792T>G	c.(4792-4794)Ttt>Gtt	p.F1598V	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1598					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCACTCACAAAGCTTACAACA	0.443000													14	30					0	0	0.435327	0	0
STON2	85439	broad.mit.edu	37	14	81743256	81743256	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:81743256T>A	ENST00000555447.1	-	6	2811	c.2399A>T	c.(2398-2400)gAc>gTc	p.D800V	STON2_ENST00000267540.2_Missense_Mutation_p.D800V	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	800	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGAGTTTTTGTCCGGCAGTCG	0.463000													47	85					0	0	0.870114	0	0
LIN9	286826	broad.mit.edu	37	1	226453251	226453251	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:226453251C>G	ENST00000328205.5	-	10	1614	c.1069G>C	c.(1069-1071)Gaa>Caa	p.E357Q	LIN9_ENST00000481685.1_Missense_Mutation_p.E322Q|LIN9_ENST00000366801.1_Missense_Mutation_p.E306Q	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	341					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ATAAGAAATTCTACTGGAAAA	0.338000													7	12					0	0	0.278610	0	0
NOTCH2	4853	broad.mit.edu	37	1	120509106	120509106	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:120509106T>A	ENST00000256646.2	-	9	1679	c.1460A>T	c.(1459-1461)aAa>aTa	p.K487I		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	487	EGF-like 12; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGCACACCTTTGAAACCTAA	0.398000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				25	52					0	0	0.706142	0	0
ITPR1	3708	broad.mit.edu	37	3	4712497	4712497	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:4712497G>A	ENST00000302640.8	+	19	2396	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V	ITPR1_ENST00000354582.6_Silent_p.V697V|ITPR1_ENST00000357086.4_Silent_p.V697V|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000423119.2_Silent_p.V697V|ITPR1_ENST00000443694.2_Silent_p.V682V|ITPR1_ENST00000456211.2_Silent_p.V682V	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	697					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGGAAGAGGTGTGGCTGTTTT	0.493000													3	18					0	0	0.115264	0	0
VAMP7	6845	broad.mit.edu	37	X	155171606	155171606	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:155171606G>T	ENST00000262640.6	+	7	669	c.586G>T	c.(586-588)Gaa>Taa	p.E196*	VAMP7_ENST00000286448.6_Silent_p.V218V|VAMP7_ENST00000460621.1_Silent_p.V177V	NM_001185183.1	NP_001172112.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	0					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAAGCTGTGTGAAGAAATAGG	0.393000													4	33					0.00024832	0.00028486	0.150653	1	0
C1orf94	84970	broad.mit.edu	37	1	34663381	34663381	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:34663381G>T	ENST00000488417.1	+	2	996	c.876G>T	c.(874-876)ctG>ctT	p.L292L	C1orf94_ENST00000373374.3_Silent_p.L102L	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	102							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				TTCTGCTGCTGCCTCCCCGAC	0.597000													19	43					1.56452e-12	2.57607e-12	0.557998	1	0
GALNT14	79623	broad.mit.edu	37	2	31147628	31147628	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:31147628C>A	ENST00000349752.5	-	12	1852	c.1213G>T	c.(1213-1215)Gag>Tag	p.E405*	GALNT14_ENST00000406653.1_Nonsense_Mutation_p.E385*|GALNT14_ENST00000356174.3_Nonsense_Mutation_p.E372*|GALNT14_ENST00000420311.2_Nonsense_Mutation_p.E370*|GALNT14_ENST00000324589.5_Nonsense_Mutation_p.E410*|GALNT14_ENST00000486564.1_Intron	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	405						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					TAGATATTCTCCAGGTACCAC	0.532000													8	30					0.000442599	0.000500216	0.335167	1	0
DNAH17	8632	broad.mit.edu	37	17	76547656	76547656	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:76547656C>T	ENST00000389840.5	-	16	2476	c.2352G>A	c.(2350-2352)aaG>aaA	p.K784K	DNAH17_ENST00000585328.1_Silent_p.K784K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTTGTTTTGCCTTTTGCATCC	0.463000													22	65					0	0	0.624587	0	0
FTCD	10841	broad.mit.edu	37	21	47571592	47571592	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:47571592C>A	ENST00000397748.1	-	5	559	c.516G>T	c.(514-516)ggG>ggT	p.G172G	FTCD_ENST00000291670.5_Silent_p.G172G|FTCD_ENST00000359679.2_Silent_p.G172G|FTCD-AS1_ENST00000446649.1_RNA|FTCD_ENST00000397746.3_Silent_p.G172G|FTCD_ENST00000355384.2_Silent_p.G172G|FTCD_ENST00000397743.1_Silent_p.G172G|FTCD_ENST00000498355.2_5'UTR			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	172	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TGGCCGTGGCCCCCCAACTGG	0.642000													11	62					0.00136819	0.00149756	0.411799	1	0
KLHL4	56062	broad.mit.edu	37	X	86877411	86877411	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:86877411A>C	ENST00000373119.4	+	5	1270	c.1125A>C	c.(1123-1125)ttA>ttC	p.L375F	KLHL4_ENST00000373114.4_Missense_Mutation_p.L375F	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	375						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GACTGCCATTACTCCCACCAC	0.393000													31	76					0	0	0.750413	0	0
NUP188	23511	broad.mit.edu	37	9	131730940	131730940	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:131730940G>T	ENST00000372577.2	+	9	762	c.741G>T	c.(739-741)agG>agT	p.R247S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	247					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						TTGGTAGTAGGCAGACCAATA	0.393000													7	53					1.12685e-05	1.39759e-05	0.307466	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42853627	42853627	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:42853627T>C	ENST00000455697.1	-	8	2765	c.2480A>G	c.(2479-2481)aAt>aGt	p.N827S	PRICKLE1_ENST00000552240.1_Missense_Mutation_p.N827S|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.N827S|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.N827S|RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.N827S	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	827					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		AATAATACAATTTTTGCCCTT	0.398000													42	62					0	0	0.859065	0	0
QDPR	5860	broad.mit.edu	37	4	17492369	17492369	+	Splice_Site	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:17492369C>A	ENST00000281243.5	-	6	725		c.e6-1		QDPR_ENST00000428702.2_Splice_Site|QDPR_ENST00000508623.1_Intron|QDPR_ENST00000513615.1_Splice_Site	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase						dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	CAGGGTAACCCTGCAATGGAC	0.493000													3	27					0.115264	0.117416	0.115264	1	0
HHIPL2	79802	broad.mit.edu	37	1	222700353	222700353	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:222700353T>G	ENST00000343410.6	-	7	1821	c.1763A>C	c.(1762-1764)tAt>tCt	p.Y588S		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	588					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		ACGTGGTGCATAGGCACTTGG	0.433000													11	15					0	0	0.387290	0	0
ITIH5	80760	broad.mit.edu	37	10	7627984	7627984	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:7627984G>T	ENST00000256861.6	-	8	1066	c.988C>A	c.(988-990)Cgt>Agt	p.R330S	ITIH5_ENST00000397146.2_Missense_Mutation_p.R330S|ITIH5_ENST00000446830.2_Missense_Mutation_p.R112S|ITIH5_ENST00000298441.6_Missense_Mutation_p.R116S|ITIH5_ENST00000397145.2_Missense_Mutation_p.R330S|ITIH5_ENST00000434980.1_5'UTR	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	330	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						ATACTGAAACGGTCCTGGGGT	0.468000													6	36					0.00116845	0.0012863	0.217242	1	0
SLC44A1	23446	broad.mit.edu	37	9	108097868	108097868	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:108097868C>T	ENST00000374720.3	+	4	541	c.294C>T	c.(292-294)tgC>tgT	p.C98C	SLC44A1_ENST00000374723.1_Silent_p.C98C|SLC44A1_ENST00000607692.1_3'UTR|SLC44A1_ENST00000374724.1_Silent_p.C98C	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	98						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	TGGATCCATGCAACCTGGACT	0.403000													21	53					0	0	0.575678	0	0
CYGB	114757	broad.mit.edu	37	17	74533500	74533500	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:74533500C>A	ENST00000293230.5	-	1	487	c.125G>T	c.(124-126)gGg>gTg	p.G42V	PRCD_ENST00000592432.1_Intron|CYGB_ENST00000589342.1_Missense_Mutation_p.G42V|CYGB_ENST00000589145.1_Intron	NM_134268.4	NP_599030.1	Q8WWM9	CYGB_HUMAN	cytoglobin	42	Globin.				response to oxidative stress	cytoplasm	heme binding|oxygen binding|oxygen transporter activity|peroxidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)	7						GATGGCCACCCCCACGTCCTC	0.741000													3	25					0.115264	0.117416	0.115264	1	0
FRG1B	284802	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													6	58					0	0	0.248553	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77094406	77094406	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:77094406G>T	ENST00000328299.3	+	5	981	c.833G>T	c.(832-834)aGg>aTg	p.R278M		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	278					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						GGGGGTCATAGGTTTATCACT	0.378000													14	36					1.5842e-08	2.22487e-08	0.435327	1	0
LRRC56	115399	broad.mit.edu	37	11	540786	540786	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:540786G>T	ENST00000270115.7	+	4	602	c.102G>T	c.(100-102)caG>caT	p.Q34H		NM_198075.3	NP_932341.1	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	34										kidney(1)|lung(4)|skin(1)	6		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTGCCCACAGAGCAAGGGCC	0.682000													5	13					0.0215528	0.0225566	0.217242	1	0
OR5B12	390191	broad.mit.edu	37	11	58207463	58207463	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:58207463G>A	ENST00000302572.2	-	1	183	c.162C>T	c.(160-162)caC>caT	p.H54H		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ACATGGGGGTGTGGAGACAGG	0.493000													11	49					0	0	0.361761	0	0
COL14A1	7373	broad.mit.edu	37	8	121344948	121344948	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:121344948G>A	ENST00000297848.3	+	42	5029	c.4759G>A	c.(4759-4761)Gga>Aga	p.G1587R	COL14A1_ENST00000247781.3_Missense_Mutation_p.G1492R|COL14A1_ENST00000309791.4_Missense_Mutation_p.G1587R	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1587	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGAAGCATGGGACCGCAAGG	0.502000													8	15					0	0	0.361761	0	0
RNF150	57484	broad.mit.edu	37	4	141832458	141832458	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:141832458C>A	ENST00000306799.3	-	6	1565	c.912G>T	c.(910-912)ctG>ctT	p.L304L	RNF150_ENST00000420921.2_Silent_p.L205L|RNF150_ENST00000507500.1_Silent_p.L346L|RNF150_ENST00000379512.2_Silent_p.L205L|RNF150_ENST00000515673.1_Silent_p.L346L	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	346						integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					GTGGACCTCCCAGAGAGCCCT	0.547000													19	63					3.51602e-12	5.7154e-12	0.575678	1	0
CT45A5	441521	broad.mit.edu	37	X	134947917	134947917	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:134947917G>T	ENST00000370724.3	-	3	652	c.408C>A	c.(406-408)tgC>tgA	p.C136*	CT45A4_ENST00000420087.2_Intron|CT45A5_ENST00000491480.1_Nonsense_Mutation_p.C136*	NM_001007551.3|NM_001172288.1	NP_001007552.1|NP_001165759.1	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	136										endometrium(1)|large_intestine(2)|lung(6)	9						TTCGTCCAAGGCATCGGATTT	0.398000													42	93					1.59361e-14	2.76708e-14	0.827153	1	0
ACSBG1	23205	broad.mit.edu	37	15	78474319	78474319	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:78474319C>A	ENST00000258873.4	-	8	1268	c.1063G>T	c.(1063-1065)Gcc>Tcc	p.A355S	ACSBG1_ENST00000560817.1_Missense_Mutation_p.A113S|ACSBG1_ENST00000541759.1_Missense_Mutation_p.A113S	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	355					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						ACCTTCAGGGCGTCGGGTTCG	0.612000													8	38					0.00448238	0.00479627	0.307466	1	0
IL1RL1	9173	broad.mit.edu	37	2	102968277	102968277	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:102968277C>A	ENST00000233954.1	+	11	1838	c.1567C>A	c.(1567-1569)Ctg>Atg	p.L523M		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	523	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						TAAAAGGTCCCTGAATTCTAA	0.512000													7	46					4.93089e-13	8.33451e-13	0.457914	1	0
PEG3	5178	broad.mit.edu	37	19	57326402	57326402	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:57326402G>C	ENST00000326441.9	-	10	3771	c.3408C>G	c.(3406-3408)gaC>gaG	p.D1136E	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.D1136E|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.D1012E|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.D1010E|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1136					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACTCCCGACTGTCAACCAGGC	0.483000													51	118					0	0	0.870114	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512327	68512327	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:68512327G>A	ENST00000370981.1	-	4	1290	c.654C>T	c.(652-654)acC>acT	p.T218T	GNG12-AS1_ENST00000420587.1_RNA|GNG12-AS1_ENST00000413628.1_RNA|DIRAS3_ENST00000395201.1_Silent_p.T218T			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	218					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCTTCTCAGTGGTGTTGGGCA	0.507000													48	91					0	0	0.870114	0	0
COL12A1	1303	broad.mit.edu	37	6	75841753	75841753	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:75841753G>A	ENST00000322507.8	-	35	6149	c.5840C>T	c.(5839-5841)cCt>cTt	p.P1947L	COL12A1_ENST00000345356.6_Missense_Mutation_p.P783L|COL12A1_ENST00000416123.2_Missense_Mutation_p.P1947L|COL12A1_ENST00000483888.2_Missense_Mutation_p.P1947L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1947	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GAGGCTGTTAGGTGTAGGATT	0.453000													17	56					0	0	0.539581	0	0
MNDA	4332	broad.mit.edu	37	1	158815391	158815391	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:158815391G>A	ENST00000368141.4	+	5	846	c.585G>A	c.(583-585)caG>caA	p.Q195Q		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	195					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AGGAAACCCAGGCCCAACGGC	0.512000													14	34					0	0	0.457914	0	0
OR4E2	26686	broad.mit.edu	37	14	22133880	22133880	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:22133880C>A	ENST00000408935.1	+	1	584	c.584C>A	c.(583-585)aCa>aAa	p.T195K		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		ACATACCTCACAGGAATACTG	0.463000													9	64					0.0581538	0.0600398	0.335167	1	0
ZNF746	155061	broad.mit.edu	37	7	149174137	149174137	+	Splice_Site	SNP	A	A	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:149174137A>C	ENST00000340622.3	-	6	994	c.712_splice	c.e6-1	p.G238_splice	ZNF746_ENST00000458143.2_Splice_Site_p.G238_splice			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	238					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TGGAATGGACACCTGCGGTAA	0.622000													9	32					0	0	0.335167	0	0
MEPE	56955	broad.mit.edu	37	4	88766569	88766569	+	Silent	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:88766569T>C	ENST00000497649.2	+	6	855	c.477T>C	c.(475-477)agT>agC	p.S159S	MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000540395.1_Silent_p.S70S|MEPE_ENST00000560249.1_Silent_p.S70S|MEPE_ENST00000361056.3_Silent_p.S183S|MEPE_ENST00000424957.3_Silent_p.S183S|MEPE_ENST00000395102.4_Silent_p.S214S			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	183					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TCCCAGCAAGTATGAATTATG	0.413000													22	59					0	0	0.592651	0	0
SLC28A1	9154	broad.mit.edu	37	15	85488008	85488008	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:85488008G>A	ENST00000394573.1	+	18	1986	c.1784G>A	c.(1783-1785)gGg>gAg	p.G595E	SLC28A1_ENST00000537624.1_Missense_Mutation_p.G595E|SLC28A1_ENST00000538177.1_Missense_Mutation_p.G429E|SLC28A1_ENST00000286749.3_Missense_Mutation_p.G595E|SLC28A1_ENST00000537216.1_Intron	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	595					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding	p.G595V(1)		breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ATGCCCAGGGGGGCTGAAGTT	0.602000													18	71					0	0	0.639603	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090327	238090327	+	RNA	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:238090327C>A	ENST00000450451.1	+	0	1833					NR_027247.2																						GCATCCTGACCCTGAAGTACC	0.597000													15	50					6.31663e-08	8.55657e-08	0.479597	1	0
ACTC1	70	broad.mit.edu	37	15	35084623	35084623	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:35084623G>T	ENST00000290378.4	-	4	1257	c.602C>A	c.(601-603)tCc>tAc	p.S201Y	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	201					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GGTGACAAAGGAGTAGCCACG	0.537000													14	58					0.000219431	0.000253241	0.457914	1	0
TP53RK	112858	broad.mit.edu	37	20	45315870	45315870	+	Splice_Site	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:45315870C>T	ENST00000372102.3	-	2	314	c.288_splice	c.e2-1	p.E97_splice				Q96S44	PRPK_HUMAN	TP53 regulating kinase	0	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			kidney(1)|large_intestine(1)|lung(4)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				GGCAGATATTCCTGAAATCAA	0.343000													61	180					0	0	0.870114	0	0
KCNMB1	3779	broad.mit.edu	37	5	169805858	169805858	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:169805858G>A	ENST00000274629.4	-	4	868	c.426C>T	c.(424-426)aaC>aaT	p.N142N	KCNIP1_ENST00000518527.1_Intron|KCNIP1_ENST00000377360.4_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	142					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		CGCTGGTTTCGTTCCCCCGAG	0.617000													8	38					0	0	0.278610	0	0
GCNT2	2651	broad.mit.edu	37	6	10586824	10586824	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:10586824G>T	ENST00000265012.4	+	1	846	c.602G>T	c.(601-603)cGg>cTg	p.R201L	GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000316170.3_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000495262.1_Intron	NM_145655.3	NP_663630.2	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	201						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AAAACCAACCGGGAGATAGTT	0.488000													25	73					5.45024e-15	9.59443e-15	0.654019	1	0
GSTA4	2941	broad.mit.edu	37	6	52850269	52850269	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:52850269C>A	ENST00000370959.1	-	4	369	c.252G>T	c.(250-252)aaG>aaT	p.K84N	GSTA4_ENST00000486559.1_5'UTR|GSTA4_ENST00000541324.1_Intron|GSTA4_ENST00000370960.1_Intron			O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	84					glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity			endometrium(1)|lung(3)|skin(2)|urinary_tract(1)	7	Lung NSC(77;0.103)				Glutathione(DB00143)	CCTTGAGGTTCTTGCCAAAGA	0.488000													17	43					2.94398e-08	4.07464e-08	0.557998	1	0
CD177	57126	broad.mit.edu	37	19	43859722	43859722	+	RNA	SNP	T	T	C	rs142707564	by1000genomes	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:43859722T>C	ENST00000378009.4	+	0	421				CD177_ENST00000378012.2_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				AGGTTGACTCTTGAGGCCAGC	0.512000													3	29					0	0	0.217242	0	0
DPY19L2	283417	broad.mit.edu	37	12	63974554	63974554	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:63974554C>A	ENST00000324472.4	-	19	1971	c.1788G>T	c.(1786-1788)gtG>gtT	p.V596V	DPY19L2_ENST00000413230.2_Silent_p.V43V	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	596					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GTATTGACATCACTGTTAAAA	0.353000													11	44					3.03607e-14	5.22423e-14	0.411799	1	0
SH3GL2	6456	broad.mit.edu	37	9	17791274	17791274	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:17791274G>T	ENST00000380607.4	+	7	790	c.670G>T	c.(670-672)Gag>Tag	p.E224*	SH3GL2_ENST00000537391.1_Nonsense_Mutation_p.E177*	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	224	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGCTCAGCTGGAGTACCACAA	0.458000													18	87					3.32936e-07	4.35553e-07	0.539581	1	0
TBC1D32	221322	broad.mit.edu	37	6	121629179	121629179	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:121629179C>A	ENST00000275159.6	-	5	632	c.633G>T	c.(631-633)tgG>tgT	p.W211C	TBC1D32_ENST00000398212.2_Missense_Mutation_p.W211C					TBC1 domain family, member 32																		AGAGAGTAGTCCAATTTTCAC	0.338000													8	31					1.12685e-05	1.39759e-05	0.307466	1	0
DNAH2	146754	broad.mit.edu	37	17	7721353	7721353	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:7721353C>T	ENST00000572933.1	+	68	11786	c.10326C>T	c.(10324-10326)aaC>aaT	p.N3442N	DNAH2_ENST00000389173.2_Silent_p.N3442N			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3442	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACTTCAGAACGTGCAGGAAT	0.522000													15	113					0	0	0.479597	0	0
ADCY2	108	broad.mit.edu	37	5	7773143	7773143	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:7773143G>T	ENST00000338316.4	+	18	2402	c.2313G>T	c.(2311-2313)gtG>gtT	p.V771V	ADCY2_ENST00000537121.1_Silent_p.V591V	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	771					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGGCCTTGGTGGGCTACAACA	0.517000													42	83					1.04594e-18	1.90261e-18	0.819951	1	0
TRIML2	205860	broad.mit.edu	37	4	189026054	189026054	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:189026054C>A	ENST00000512729.1	-	2	446	c.72G>T	c.(70-72)agG>agT	p.R24S	TRIML2_ENST00000536972.1_Missense_Mutation_p.R74S|TRIML2_ENST00000326754.3_Missense_Mutation_p.R24S	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	24							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CAAGTTTCTCCCTCGATGTGT	0.393000													20	73					2.4624e-09	3.52298e-09	0.575678	1	0
RNF182	221687	broad.mit.edu	37	6	13977461	13977461	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:13977461G>T	ENST00000488300.1	+	3	634	c.111G>T	c.(109-111)ctG>ctT	p.L37L	RNF182_ENST00000537388.1_Silent_p.L37L|RNF182_ENST00000544682.1_Silent_p.L37L|RNF182_ENST00000537663.1_Silent_p.L37L	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	37						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CCAAAGTGCTGGAGTGTTGTC	0.473000													40	102					1.60099e-16	2.87125e-16	0.804634	1	0
VCAN	1462	broad.mit.edu	37	5	82875806	82875806	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:82875806C>T	ENST00000265077.3	+	14	10453	c.9888C>T	c.(9886-9888)tgC>tgT	p.C3296C	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000512590.2_Silent_p.C1494C|VCAN_ENST00000342785.4_Silent_p.C1542C|VCAN_ENST00000343200.5_Silent_p.C2309C|VCAN_ENST00000502527.2_Silent_p.C555C|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3296	Sushi.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.C3296C(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TAGTCGCTTGCGGCCAGCCCC	0.373000													13	54					0	0	0.411799	0	0
NLRP9	338321	broad.mit.edu	37	19	56249718	56249718	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:56249718T>A	ENST00000332836.2	-	1	50	c.23A>T	c.(22-24)gAt>gTt	p.D8V		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	8	DAPIN.					cytoplasm	ATP binding	p.D8G(1)		NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAAGCCAAAATCCGAAAAAAA	0.398000													22	86					0	0	0.592651	0	0
UBASH3B	84959	broad.mit.edu	37	11	122653759	122653759	+	Splice_Site	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:122653759A>T	ENST00000284273.5	+	5	976		c.e5-1			NM_032873.4	NP_116262.2	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing B							cytoplasm|nucleus	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|prostate(1)|skin(2)|stomach(2)	26		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		TCCTTTTTCCAGAAGTGCATG	0.453000													47	234					0	0	0.870114	0	0
DGKK	139189	broad.mit.edu	37	X	50111949	50111949	+	RNA	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:50111949G>T	ENST00000376025.2	-	0	3864							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CTACAGTTGAGATCTCGATGG	0.388000													13	31					3.41278e-10	5.09251e-10	0.520397	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58565031	58565031	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:58565031C>T	ENST00000282326.1	+	6	1086	c.839C>T	c.(838-840)tCg>tTg	p.S280L		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	280					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCAGGCATCTCGGTAGTGCCG	0.627000													9	45					0	0	0.335167	0	0
CPA3	1359	broad.mit.edu	37	3	148614332	148614332	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:148614332C>T	ENST00000296046.3	+	11	1144	c.1092C>T	c.(1090-1092)gaC>gaT	p.D364D	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	364					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTTCTTTAGACTGGGCTTATG	0.388000													6	57					0	0	0.278610	0	0
USH2A	7399	broad.mit.edu	37	1	216390770	216390770	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:216390770G>T	ENST00000366943.2	-	15	3502	c.3116C>A	c.(3115-3117)gCa>gAa	p.A1039E	USH2A_ENST00000366942.3_Missense_Mutation_p.A1039E|USH2A_ENST00000307340.3_Missense_Mutation_p.A1039E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1039	Laminin EGF-like 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAGTGGCTTGCACTGGGAAC	0.473000										HNSCC(13;0.011)			15	19					7.93312e-07	1.0238e-06	0.457914	1	0
TTI1	9675	broad.mit.edu	37	20	36641088	36641088	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:36641088G>T	ENST00000373448.2	-	3	1369	c.1131C>A	c.(1129-1131)agC>agA	p.S377R	TTI1_ENST00000449821.1_Missense_Mutation_p.S377R|TTI1_ENST00000487362.1_Intron|TTI1_ENST00000373447.3_Missense_Mutation_p.S377R	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	377							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GGGAATGCAGGCTTTCTGACA	0.453000													59	134					1.61742e-36	3.15231e-36	0.870114	1	0
P2RX2	22953	broad.mit.edu	37	12	133196156	133196156	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:133196156C>A	ENST00000389110.3	+	2	342	c.305C>A	c.(304-306)cCc>cAc	p.P102H	P2RX2_ENST00000351222.4_Intron|P2RX2_ENST00000350048.5_Missense_Mutation_p.P102H|P2RX2_ENST00000352418.4_Silent_p.P79P|P2RX2_ENST00000343948.4_Missense_Mutation_p.P102H|P2RX2_ENST00000348800.5_Missense_Mutation_p.P102H|P2RX2_ENST00000449132.2_Missense_Mutation_p.P102H	NM_170682.2|NM_170683.2|NM_174873.1	NP_733782.1|NP_733783.1|NP_777362.1	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2	102					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		GTGAAGCCCCCCGAGGTgcgg	0.711000													9	48					0.00448238	0.00479627	0.307466	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237240	140237240	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140237240C>A	ENST00000307360.5	+	1	1607	c.1607C>A	c.(1606-1608)gCg>gAg	p.A536E	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.A536V(1)|p.?(1)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGAGCGCGCGCGATGGG	0.677000													30	24					2.12542e-12	3.48459e-12	0.706142	1	0
NR1H4	9971	broad.mit.edu	37	12	100904904	100904904	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:100904904C>T	ENST00000548884.1	+	4	969	c.428C>T	c.(427-429)aCc>aTc	p.T143I	NR1H4_ENST00000188403.7_Missense_Mutation_p.T153I|NR1H4_ENST00000549996.1_Missense_Mutation_p.T143I|NR1H4_ENST00000551379.1_Missense_Mutation_p.T153I|NR1H4_ENST00000392986.3_Missense_Mutation_p.T143I	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	153					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						AATGCACTGACCTGTGAGGGG	0.468000													11	68					0	0	0.411799	0	0
COL20A1	57642	broad.mit.edu	37	20	61956826	61956826	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:61956826C>A	ENST00000422202.1	+	27	3417	c.3349C>A	c.(3349-3351)Cat>Aat	p.H1117N	COL20A1_ENST00000435874.1_Missense_Mutation_p.H1117N|COL20A1_ENST00000326996.6_Missense_Mutation_p.H1142N|COL20A1_ENST00000358894.6_Missense_Mutation_p.H1110N			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1110	Collagen-like 1.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GAAGGGAGACCATGGGCTTCC	0.672000													16	37					5.03518e-11	7.75581e-11	0.557998	1	0
OR2C3	81472	broad.mit.edu	37	1	247694869	247694869	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:247694869G>T	ENST00000366487.3	-	2	1306	c.945C>A	c.(943-945)ggC>ggA	p.G315G	GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000527084.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GCGCCAGCTTGCCTGCAGAGC	0.522000													20	35					4.96729e-08	6.7768e-08	0.575678	1	0
CATSPERD	257062	broad.mit.edu	37	19	5776216	5776216	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:5776216G>T	ENST00000381624.3	+	21	2047	c.1986G>T	c.(1984-1986)agG>agT	p.R662S	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	662						integral to membrane											CCCCTTTGAGGTGGCCAGACG	0.562000													17	57					1.5739e-10	2.36704e-10	0.500413	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140784598	140784598	+	Silent	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140784598C>G	ENST00000573521.1	+	1	2079	c.2079C>G	c.(2077-2079)ctC>ctG	p.L693L	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCTACCTCGTTGTGGCTG	0.597000													30	107					0	0	0.729181	0	0
TLR1	7096	broad.mit.edu	37	4	38800341	38800341	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:38800341G>T	ENST00000308979.2	-	4	385	c.112C>A	c.(112-114)Cac>Aac	p.H38N	TLR1_ENST00000502213.2_Missense_Mutation_p.H38N	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	38					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						TTAGGAACGTGGATGAGACCG	0.323000													20	52					5.03518e-11	7.75581e-11	0.557998	1	0
CXorf57	55086	broad.mit.edu	37	X	105855611	105855611	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:105855611G>C	ENST00000372548.4	+	1	410	c.301G>C	c.(301-303)Gat>Cat	p.D101H	CXorf57_ENST00000372544.2_Missense_Mutation_p.D101H	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	101										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						GACGATCTCAGATGGGGTGTA	0.498000													49	116					0	0	0.870114	0	0
AMY2A	279	broad.mit.edu	37	1	104160118	104160118	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:104160118C>A	ENST00000414303.2	+	1	120	c.56C>A	c.(55-57)cCa>cAa	p.P19Q		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	19					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	CAGTATTCCCCAAATACACAA	0.398000													62	143					1.52378e-38	3.01597e-38	0.870114	1	0
DOCK11	139818	broad.mit.edu	37	X	117676698	117676698	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:117676698A>G	ENST00000276204.6	+	2	187	c.113A>G	c.(112-114)aAa>aGa	p.K38R	DOCK11_ENST00000276202.7_Missense_Mutation_p.K38R			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	38					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						GAAAAGGCCAAAGTTGTTGAG	0.368000													40	84					0	0	0.819951	0	0
NELL2	4753	broad.mit.edu	37	12	44915846	44915846	+	Silent	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:44915846A>G	ENST00000429094.2	-	18	2616	c.2112T>C	c.(2110-2112)aaT>aaC	p.N704N	NELL2_ENST00000549027.1_Silent_p.N703N|NELL2_ENST00000437801.2_Silent_p.N754N|NELL2_ENST00000551601.1_Silent_p.N656N|NELL2_ENST00000395487.2_Silent_p.N703N|NELL2_ENST00000333837.4_Silent_p.N727N|NELL2_ENST00000452445.2_Silent_p.N704N	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	704	VWFC 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AAGTTTCCCCATTTTGATGGA	0.453000													4	34					0	0	0.150653	0	0
WDFY3	23001	broad.mit.edu	37	4	85724565	85724565	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:85724565C>A	ENST00000322366.6	-	16	2892	c.2485G>T	c.(2485-2487)Gac>Tac	p.D829Y	WDFY3-AS1_ENST00000510449.1_RNA|WDFY3_ENST00000512267.1_5'UTR|WDFY3_ENST00000295888.4_Missense_Mutation_p.D829Y			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	829						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGTTTCAGGTCGGCAACATTT	0.423000													8	33					0.000157383	0.000182183	0.278610	1	0
PDGFRA	5156	broad.mit.edu	37	4	55139897	55139897	+	Splice_Site	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:55139897A>G	ENST00000257290.5	+	10	1889	c.1558_splice	c.e10+1	p.T520_splice	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	520					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGTGGCTCCCAGTGAGTTCCT	0.547000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			15	46					0	0	0.457914	0	0
THRAP3	9967	broad.mit.edu	37	1	36752483	36752483	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:36752483G>C	ENST00000354618.5	+	4	876	c.652G>C	c.(652-654)Gag>Cag	p.E218Q	THRAP3_ENST00000469141.2_Missense_Mutation_p.E218Q	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	218	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAAAGCATCTGAGAGCTCGAA	0.577000			T	USP6	aneurysmal bone cysts								31	75					0	0	0.717897	0	0
AFP	174	broad.mit.edu	37	4	74308081	74308081	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:74308081G>A	ENST00000395792.2	+	5	651	c.551G>A	c.(550-552)cGc>cAc	p.R184H	AFP_ENST00000226359.2_Missense_Mutation_p.R184H	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	184	Albumin 1.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGGGCTGCTCGCTATGACAAA	0.373000									Alpha-Fetoprotein, Hereditary Persistence of				13	25					0	0	0.411799	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523733	24523733	+	Translation_Start_Site	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:24523733C>A	ENST00000376862.3	+	0	633					NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1						response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						GAGAGAGTACCATGGATGGCA	0.502000													29	76					1.17739e-12	1.9555e-12	0.693898	1	0
PCDHGB2	56103	broad.mit.edu	37	5	140741739	140741739	+	Silent	SNP	G	G	T	rs143064226	by1000genomes	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140741739G>T	ENST00000522605.1	+	1	2037	c.2037G>T	c.(2035-2037)cgG>cgT	p.R679R	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCGCCGGGAGCCCTCTG	0.597000													29	64					5.77227e-19	1.05503e-18	0.729181	1	0
DMD	1756	broad.mit.edu	37	X	32380912	32380912	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:32380912G>T	ENST00000357033.4	-	37	5524	c.5318C>A	c.(5317-5319)aCt>aAt	p.T1773N	DMD_ENST00000378677.2_Missense_Mutation_p.T1769N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1773	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACCTTTCCAGTCTTAATTCT	0.483000													33	93					2.68265e-12	4.37937e-12	0.769981	1	0
MCL1	4170	broad.mit.edu	37	1	150551692	150551692	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:150551692C>A	ENST00000369026.2	-	1	374	c.315G>T	c.(313-315)gcG>gcT	p.A105A	MCL1_ENST00000307940.3_Silent_p.A105A	NM_001197320.1|NM_021960.4	NP_001184249.1|NP_068779.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	105	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CAAGCGGCGCCGCGCGGCGGG	0.746000													10	16					2.17888e-05	2.62565e-05	0.335167	1	0
PTPRT	11122	broad.mit.edu	37	20	40828028	40828028	+	Missense_Mutation	SNP	C	C	A	rs142326423		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:40828028C>A	ENST00000373198.3	-	17	2644	c.2409G>T	c.(2407-2409)agG>agT	p.R803S	PTPRT_ENST00000373201.1_Splice_Site_p.R771_splice|PTPRT_ENST00000373184.1_Splice_Site_p.R771_splice|PTPRT_ENST00000356100.2_Splice_Site_p.R790_splice|PTPRT_ENST00000373187.1_Splice_Site_p.L781_splice|PTPRT_ENST00000373190.1_Splice_Site_p.L781_splice|PTPRT_ENST00000373193.3_Missense_Mutation_p.R784S	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	781					homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.R803R(1)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGCCAGCTTCCTTTGGGACA	0.562000													65	128					9.04393e-38	1.77168e-37	0.870114	1	0
IL1RL1	9173	broad.mit.edu	37	2	102968276	102968276	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:102968276C>A	ENST00000233954.1	+	11	1837	c.1566C>A	c.(1564-1566)tcC>tcA	p.S522S		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	522	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ATAAAAGGTCCCTGAATTCTA	0.512000													7	44					4.93089e-13	8.33451e-13	0.457914	1	0
ZNF408	79797	broad.mit.edu	37	11	46726982	46726982	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:46726982C>T	ENST00000311764.2	+	5	1962	c.1732C>T	c.(1732-1734)Ccc>Tcc	p.P578S		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGGAGAGAGGCCCTTTCCCTG	0.667000													7	37					0	0	0.248553	0	0
NUP188	23511	broad.mit.edu	37	9	131730939	131730939	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:131730939G>T	ENST00000372577.2	+	9	761	c.740G>T	c.(739-741)aGg>aTg	p.R247M		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	247					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						TTTGGTAGTAGGCAGACCAAT	0.393000													8	55					2.17888e-05	2.62565e-05	0.335167	1	0
AMMECR1L	83607	broad.mit.edu	37	2	128631402	128631402	+	Splice_Site	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:128631402T>C	ENST00000272647.5	-	3	667	c.407_splice	c.e3+1	p.Y136_splice	AMMECR1L_ENST00000393001.1_Splice_Site_p.Y136_splice	NM_001199140.1	NP_001186069.1	Q6DCA0	AMERL_HUMAN	AMMECR1-like	136	AMMECR1.									central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	9	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		ATTTACTCACTAGGGGTCATT	0.498000													57	124					0	0	0.870114	0	0
GRM1	2911	broad.mit.edu	37	6	146755768	146755768	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:146755768G>A	ENST00000361719.2	+	9	3891	c.3421G>A	c.(3421-3423)Gat>Aat	p.D1141N	GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000282753.1_Missense_Mutation_p.D1141N	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	1141					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GACCCCGGATGATTCGCCTGC	0.662000													6	66					0	0	0.217242	0	0
BTRC	8945	broad.mit.edu	37	10	103190200	103190200	+	Silent	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:103190200A>T	ENST00000370187.3	+	2	265	c.147A>T	c.(145-147)acA>acT	p.T49T	BTRC_ENST00000408038.2_Intron|BTRC_ENST00000393441.4_Silent_p.T34T	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	49					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		GCGCACTCACAGCTTTCCAGG	0.522000													17	34					0	0	0.539581	0	0
DNAH8	1769	broad.mit.edu	37	6	38891790	38891790	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:38891790G>T	ENST00000359357.3	+	71	10417	c.10163G>T	c.(10162-10164)tGc>tTc	p.C3388F	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.C3605F|RP1-207H1.3_ENST00000418399.1_RNA|DNAH8_ENST00000441566.1_Missense_Mutation_p.C3352F					dynein, axonemal, heavy chain 8									p.C3388F(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATTCTGCTGTGCACGGGATTC	0.428000													18	53					9.16793e-09	1.29709e-08	0.520397	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873430	91873430	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:91873430C>T	ENST00000373094.1	+	7	4380	c.3535C>T	c.(3535-3537)Cag>Tag	p.Q1179*	PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.Q1142*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.Q1142*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.Q1161*|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.Q1171*|PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.Q1169*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1179					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ACCACTGTCACAGGCCTCTAC	0.587000													37	128					0	0	0.796494	0	0
CHL1	10752	broad.mit.edu	37	3	431095	431095	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:431095C>A	ENST00000256509.2	+	20	3050	c.2408C>A	c.(2407-2409)gCt>gAt	p.A803D	CHL1_ENST00000397491.2_Missense_Mutation_p.A787D	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	787	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAGGTCCAGGCTATCAATCAA	0.502000													7	43					0.000274275	0.000313692	0.307466	1	0
INHBA	3624	broad.mit.edu	37	7	41729603	41729603	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:41729603C>A	ENST00000242208.4	-	3	1172	c.926G>T	c.(925-927)cGg>cTg	p.R309L	INHBA_ENST00000442711.1_Missense_Mutation_p.R309L|INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	309					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CAAGCCCCGCCGACGCCGGCG	0.562000										TSP Lung(11;0.080)			31	104					1.39806e-14	2.43862e-14	0.729181	1	0
CPA3	1359	broad.mit.edu	37	3	148586701	148586701	+	Splice_Site	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:148586701G>T	ENST00000296046.3	+	3	196		c.e3-1		RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)						proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TATCTCTGCAGCTTGACTTCT	0.438000													19	45					1.67942e-08	2.34995e-08	0.539581	1	0
ZFP42	132625	broad.mit.edu	37	4	188924130	188924130	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:188924130G>T	ENST00000326866.4	+	4	577	c.169G>T	c.(169-171)Gag>Tag	p.E57*	ZFP42_ENST00000509524.1_Nonsense_Mutation_p.E57*	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	57					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TGTGTGCTATGAGCCTGGCCC	0.542000													18	65					3.41278e-10	5.09251e-10	0.520397	1	0
SEMA4C	54910	broad.mit.edu	37	2	97526878	97526878	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:97526878C>A	ENST00000305476.5	-	15	2119	c.1987G>T	c.(1987-1989)Ggg>Tgg	p.G663W		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	663					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CACACCAGCCCCAGGTTTTCC	0.701000													12	29					1.05317e-09	1.51816e-09	0.457914	1	0
SHC2	25759	broad.mit.edu	37	19	422268	422268	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:422268T>C	ENST00000264554.6	-	11	1497	c.1498A>G	c.(1498-1500)Atg>Gtg	p.M500V		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	500	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGAAGCATCCTCTCTGCC	0.701000													4	20					0	0	0.150653	0	0
SST	6750	broad.mit.edu	37	3	187386920	187386920	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:187386920G>T	ENST00000287641.3	-	2	391	c.284C>A	c.(283-285)gCt>gAt	p.A95D		NM_001048.3	NP_001039.1	P61278	SMS_HUMAN	somatostatin	95					digestion|G-protein coupled receptor protein signaling pathway|induction of apoptosis by hormones|negative regulation of cell proliferation|response to nutrient|synaptic transmission	extracellular space	hormone activity			kidney(1)|large_intestine(1)|lung(6)|pancreas(1)	9	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.00444)	Bromocriptine(DB01200)|Cysteamine(DB00847)	GGGTGCCATAGCCGGGTTTGA	0.493000													28	200					2.48779e-11	3.94331e-11	0.693898	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136549	40136549	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:40136549C>A	ENST00000278198.2	-	2	3257	c.1294G>T	c.(1294-1296)Gtt>Ttt	p.V432F	LRRC4C_ENST00000530763.1_Missense_Mutation_p.V432F|LRRC4C_ENST00000527150.1_Missense_Mutation_p.V432F|LRRC4C_ENST00000528697.1_Missense_Mutation_p.V432F			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	432	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTATTCCCAACGGAATTACTC	0.438000													35	114					2.80507e-11	4.37362e-11	0.760397	1	0
SF3A1	10291	broad.mit.edu	37	22	30737734	30737734	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:30737734C>A	ENST00000439242.1	-	7	954	c.823G>T	c.(823-825)Gag>Tag	p.E275*	SF3A1_ENST00000215793.7_Nonsense_Mutation_p.E340*	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	340					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						GGAGGCTCCTCCGCCTTCTCC	0.547000													42	131					7.05377e-20	1.31441e-19	0.870114	1	0
ABCA3	21	broad.mit.edu	37	16	2328346	2328346	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:2328346C>A	ENST00000301732.5	-	30	5361	c.4661G>T	c.(4660-4662)tGg>tTg	p.W1554L	ABCA3_ENST00000382381.3_Missense_Mutation_p.W1496L	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1554	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CACGGTGTCCCAAAGCAGGCG	0.642000													28	95					3.65163e-15	6.45797e-15	0.706142	1	0
SNORD114-28	767609	broad.mit.edu	37	14	101455516	101455516	+	RNA	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:101455516G>T	ENST00000363610.1	+	0	50					NR_003221.1																						CGATGAATACGTGTCTAGAAC	0.393000													41	73					1.07121e-22	2.02575e-22	0.827153	1	0
L1CAM	3897	broad.mit.edu	37	X	153136566	153136566	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:153136566G>T	ENST00000370060.1	-	6	658	c.469C>A	c.(469-471)Cct>Act	p.P157T	L1CAM_ENST00000370057.3_Missense_Mutation_p.P157T|L1CAM_ENST00000370055.1_Missense_Mutation_p.P152T|L1CAM_ENST00000543994.1_Missense_Mutation_p.P159T|L1CAM_ENST00000361981.3_Missense_Mutation_p.P152T|L1CAM_ENST00000538883.1_Missense_Mutation_p.P159T|L1CAM_ENST00000361699.4_Missense_Mutation_p.P157T	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	157	Ig-like C2-type 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGTTGCAAGGCAGAACCACT	0.637000													13	50					4.36969e-10	6.46985e-10	0.435327	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	40					0	0	0.278610	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791273	17791273	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:17791273G>A	ENST00000380607.4	+	7	789	c.669G>A	c.(667-669)ctG>ctA	p.L223L	SH3GL2_ENST00000537391.1_Silent_p.L176L	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	223	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AAGCTCAGCTGGAGTACCACA	0.458000													18	87					0	0	0.539581	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64766967	64766967	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:64766967C>A	ENST00000536360.1	-	3	913	c.100G>T	c.(100-102)Gaa>Taa	p.E34*				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	34					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GTCAGGAATTCCTCTTTGTAA	0.343000													6	14					8.12818e-05	9.52444e-05	0.248553	1	0
NAF1	92345	broad.mit.edu	37	4	164061434	164061434	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:164061434C>T	ENST00000274054.2	-	5	1012	c.819G>A	c.(817-819)atG>atA	p.M273I	NAF1_ENST00000422287.2_Missense_Mutation_p.M273I|NAF1_ENST00000509434.1_Start_Codon_SNP_p.M1I	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	273					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				GAGCAAAATACATAGTCTCCT	0.323000													14	39					0	0	0.457914	0	0
OR10A4	283297	broad.mit.edu	37	11	6898520	6898520	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:6898520G>T	ENST00000379829.2	+	1	665	c.642G>T	c.(640-642)ctG>ctT	p.L214L		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTTTCTTGCTGATCCTGGGAT	0.527000													15	56					7.93312e-07	1.0238e-06	0.457914	1	0
SLC9A7	84679	broad.mit.edu	37	X	46618218	46618218	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:46618218G>C	ENST00000328306.4	-	1	272	c.247C>G	c.(247-249)Ctc>Gtc	p.L83V		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	83					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						AGGATGGTGAGCGTGAGCAGC	0.627000													11	40					0	0	0.387290	0	0
RTN1	6252	broad.mit.edu	37	14	60212835	60212835	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:60212835G>T	ENST00000267484.5	-	2	941	c.606C>A	c.(604-606)ccC>ccA	p.P202P		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	202					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TCACCTCCTCGGGTCTGGTTA	0.453000													20	170					9.7654e-05	0.000114079	0.557998	1	0
PCYT1B	9468	broad.mit.edu	37	X	24608231	24608231	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:24608231C>G	ENST00000379145.1	-	4	385	c.341G>C	c.(340-342)aGa>aCa	p.R114T	PCYT1B_ENST00000356768.4_Missense_Mutation_p.R132T|PCYT1B_ENST00000379144.2_Missense_Mutation_p.R132T|PCYT1B_ENST00000492876.1_5'UTR	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	132	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	AGCTTCGTATCTCTCGGCTTC	0.458000													12	37					0	0	0.387290	0	0
KRT28	162605	broad.mit.edu	37	17	38948771	38948771	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:38948771G>A	ENST00000306658.7	-	8	1368	c.1303C>T	c.(1303-1305)Cgt>Tgt	p.R435C		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	435	Tail.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				ACTTTACCACGTTGATCTAGC	0.358000													6	15					0	0	0.217242	0	0
IGSF1	3547	broad.mit.edu	37	X	130416558	130416558	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:130416558G>T	ENST00000370904.1	-	13	1989	c.1079C>A	c.(1078-1080)aCc>aAc	p.T360N	IGSF1_ENST00000370910.1_Missense_Mutation_p.T360N|IGSF1_ENST00000370903.3_Missense_Mutation_p.T369N|IGSF1_ENST00000361420.3_Missense_Mutation_p.T369N			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	369	Ig-like C2-type 4.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						ATCGATGCTGGTGGCATCCAA	0.463000													39	51					7.04047e-22	1.32486e-21	0.812448	1	0
CSMD3	114788	broad.mit.edu	37	8	113364662	113364662	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:113364662G>T	ENST00000297405.5	-	39	6482	c.6238C>A	c.(6238-6240)Caa>Aaa	p.Q2080K	CSMD3_ENST00000343508.3_Missense_Mutation_p.Q2040K|CSMD3_ENST00000352409.3_Missense_Mutation_p.Q2010K|CSMD3_ENST00000455883.2_Missense_Mutation_p.Q1976K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2080	Sushi 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GAATATCCTTGATCACACTGA	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	25					0.307466	0.31072	0.307466	1	0
SEMA4C	54910	broad.mit.edu	37	2	97526877	97526877	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:97526877C>A	ENST00000305476.5	-	15	2120	c.1988G>T	c.(1987-1989)gGg>gTg	p.G663V		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	663					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CCACACCAGCCCCAGGTTTTC	0.701000													12	28					1.05317e-09	1.51816e-09	0.457914	1	0
ITIH5	80760	broad.mit.edu	37	10	7608307	7608307	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:7608307C>A	ENST00000256861.6	-	13	2291	c.2213G>T	c.(2212-2214)cGc>cTc	p.R738L	ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000446830.2_Missense_Mutation_p.R520L|ITIH5_ENST00000298441.6_Missense_Mutation_p.R524L	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	738					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CAAGTAAGTGCGCTGTTTCTT	0.502000													12	50					2.27111e-07	2.9916e-07	0.411799	1	0
ADAMDEC1	27299	broad.mit.edu	37	8	24242041	24242041	+	Silent	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:24242041A>T	ENST00000256412.4	+	1	244	c.24A>T	c.(22-24)ctA>ctT	p.L8L	ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	8					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TCTCCCAGCTACCTGCAGTGG	0.453000													5	10					0	0	0.184627	0	0
CENPF	1063	broad.mit.edu	37	1	214828619	214828619	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:214828619G>A	ENST00000366955.3	+	17	8526	c.8358G>A	c.(8356-8358)aaG>aaA	p.K2786K		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2882	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding	p.K2786>?(1)		NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGTTGAAGAAGGAAAATGAAC	0.323000													6	28					0	0	0.217242	0	0
SDK1	221935	broad.mit.edu	37	7	4247746	4247746	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:4247746G>T	ENST00000404826.2	+	37	5369	c.5230G>T	c.(5230-5232)Gca>Tca	p.A1744S	SDK1_ENST00000389531.3_Missense_Mutation_p.A1724S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1744	Fibronectin type-III 11.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTACTGGGAGGCAGACAGCCA	0.562000													17	59					1.56452e-12	2.57607e-12	0.557998	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745966	77745966	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:77745966C>A	ENST00000409088.3	-	3	1443	c.1029G>T	c.(1027-1029)aaG>aaT	p.K343N	LRRTM4_ENST00000409911.1_Missense_Mutation_p.K344N|LRRTM4_ENST00000409282.1_Missense_Mutation_p.K344N|LRRTM4_ENST00000409884.1_Missense_Mutation_p.K343N|LRRTM4_ENST00000409093.1_Missense_Mutation_p.K343N	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	343	LRRCT.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		CCTGGATGTGCTTAGGTCCCG	0.418000													6	13					0.00116845	0.0012863	0.217242	1	0
RGS21	431704	broad.mit.edu	37	1	192335252	192335252	+	Nonstop_Mutation	SNP	T	T	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:192335252T>G	ENST00000417209.2	+	5	631	c.457T>G	c.(457-459)Tga>Gga	p.*153G		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	0					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						CCCTTTTTTGTGAGGAAGGTA	0.328000													8	13					0	0	0.335167	0	0
CAV1	857	broad.mit.edu	37	7	116199023	116199023	+	Silent	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:116199023A>G	ENST00000341049.2	+	3	497	c.219A>G	c.(217-219)gcA>gcG	p.A73A	CAV1_ENST00000393470.1_Silent_p.A62A|CAV1_ENST00000393467.1_Silent_p.A42A|CAV1_ENST00000405348.1_Silent_p.A42A|CAV1_ENST00000393468.1_Silent_p.A42A	NM_001753.4	NP_001744.2	Q03135	CAV1_HUMAN	caveolin 1, caveolae protein, 22kDa	73					blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			ATGTGATTGCAGAACCAGAAG	0.428000													8	19					0	0	0.278610	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167866	140167866	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140167866C>T	ENST00000504120.2	+	1	1991	c.1991C>T	c.(1990-1992)aCt>aTt	p.T664I	PCDHA1_ENST00000378133.3_Missense_Mutation_p.T664I|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACGGCCACTGTGCTTGTA	0.657000													28	83					0	0	0.681144	0	0
EVC2	132884	broad.mit.edu	37	4	5664968	5664968	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:5664968C>A	ENST00000310917.2	-	9	1502	c.771G>T	c.(769-771)tgG>tgT	p.W257C	EVC2_ENST00000344938.1_Missense_Mutation_p.W337C|EVC2_ENST00000344408.5_Missense_Mutation_p.W337C	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	337						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TCTCATACTGCCAAACCTTCA	0.498000													26	65					4.59853e-10	6.78239e-10	0.693898	1	0
NSDHL	50814	broad.mit.edu	37	X	152018931	152018931	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:152018931G>T	ENST00000370274.3	+	3	425	c.231G>T	c.(229-231)caG>caT	p.Q77H	NSDHL_ENST00000440023.1_Missense_Mutation_p.Q77H	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	77					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	ATAATCCCCAGGTGCGGTTCT	0.537000													56	179					4.64219e-42	9.23603e-42	0.870114	1	0
SLC9A7	84679	broad.mit.edu	37	X	46522080	46522080	+	Splice_Site	SNP	T	T	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:46522080T>G	ENST00000328306.4	-	6	819		c.e6-2			NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7						regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GCACAGTCACTGAAAAGTGAG	0.418000													9	20					0	0	0.335167	0	0
LSM14A	26065	broad.mit.edu	37	19	34712605	34712605	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:34712605G>C	ENST00000544216.3	+	9	1407	c.1330G>C	c.(1330-1332)Ggt>Cgt	p.G444R	LSM14A_ENST00000433627.5_Missense_Mutation_p.G444R|LSM14A_ENST00000540746.2_Missense_Mutation_p.G403R	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	444					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					ATTCAGAGGAGGTCGTGGGGG	0.507000													9	27					0	0	0.361761	0	0
TTC7B	145567	broad.mit.edu	37	14	91007859	91007859	+	Silent	SNP	C	C	A	rs142524402	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:91007859C>A	ENST00000357056.2	-	21	2557	c.2436G>T	c.(2434-2436)tcG>tcT	p.S812S	TTC7B_ENST00000328459.6_Silent_p.S795S|TTC7B_ENST00000554654.1_5'UTR			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	795							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				CGTGGGCTGTCGAGTTCACCT	0.637000													13	22					9.31168e-06	1.16244e-05	0.435327	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140798052	140798052	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140798052A>T	ENST00000398594.2	+	1	626	c.626A>T	c.(625-627)cAc>cTc	p.H209L	PCDHGB3_ENST00000576222.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGCTCACCACTTGGTACTG	0.498000													17	69					0	0	0.500413	0	0
TBC1D25	4943	broad.mit.edu	37	X	48418713	48418713	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:48418713C>A	ENST00000376771.4	+	6	1758	c.1417C>A	c.(1417-1419)Cct>Act	p.P473T	TBC1D25_ENST00000537536.1_Missense_Mutation_p.P219T|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	473						intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						CATGCTGAGGCCTGCTGGTGG	0.632000													17	45					1.99824e-07	2.64127e-07	0.520397	1	0
ZNF799	90576	broad.mit.edu	37	19	12501395	12501395	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:12501395T>A	ENST00000419318.1	-	4	2470	c.1721A>T	c.(1720-1722)cAt>cTt	p.H574L	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.H606L			Q96GE5	ZN799_HUMAN	zinc finger protein 799	606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						AGTCTTTTTATGTCTATGCAA	0.408000													17	82					0	0	0.608945	0	0
SAMD3	154075	broad.mit.edu	37	6	130466509	130466509	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:130466509G>T	ENST00000368134.2	-	13	1862	c.1254C>A	c.(1252-1254)agC>agA	p.S418R	SAMD3_ENST00000439090.2_Missense_Mutation_p.S418R|SAMD3_ENST00000457563.2_Missense_Mutation_p.S442R|SAMD3_ENST00000437477.2_Missense_Mutation_p.S418R	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	418										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TGACAAAAAGGCTGGGATCAT	0.338000													6	18					1.06961e-07	1.43366e-07	0.278610	1	0
GRM7	2917	broad.mit.edu	37	3	7620820	7620820	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:7620820G>A	ENST00000486284.1	+	8	2501	c.2227G>A	c.(2227-2229)Gcc>Acc	p.A743T	GRM7_ENST00000357716.4_Missense_Mutation_p.A743T|GRM7_ENST00000389336.4_Missense_Mutation_p.A743T|GRM7_ENST00000402647.2_Missense_Mutation_p.A743T|GRM7_ENST00000403881.1_Missense_Mutation_p.A743T|GRM7_ENST00000458641.2_3'UTR	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	743					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCCTGAGCAAGCCAGAGGGGT	0.423000													7	62					0	0	0.278610	0	0
CYSLTR1	10800	broad.mit.edu	37	X	77529058	77529058	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:77529058C>A	ENST00000373304.3	-	3	478	c.186G>T	c.(184-186)atG>atT	p.M62I		NM_006639.2	NP_006630.1	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	62					elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CTAAATTAATCATGTATACTT	0.413000													9	38					0.00448238	0.00479627	0.307466	1	0
ZNF560	147741	broad.mit.edu	37	19	9578633	9578633	+	Silent	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:9578633A>T	ENST00000301480.4	-	10	1203	c.990T>A	c.(988-990)acT>acA	p.T330T		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TTGTGGAGTGAGTAAATGCTT	0.388000													16	49					0	0	0.500413	0	0
SV2C	22987	broad.mit.edu	37	5	75621336	75621336	+	Silent	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:75621336G>C	ENST00000502798.2	+	13	2590	c.2148G>C	c.(2146-2148)ctG>ctC	p.L716L	SV2C_ENST00000322285.7_Intron	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	716					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TCGTTGGGCTGTGCCTGCCTG	0.517000													21	55					0	0	0.592651	0	0
GLOD5	392465	broad.mit.edu	37	X	48629391	48629391	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:48629391G>A	ENST00000303227.6	+	3	291	c.250G>A	c.(250-252)Gag>Aag	p.E84K	GLOD5_ENST00000470676.1_3'UTR	NM_001080489.2	NP_001073958.2			glyoxalase domain containing 5											endometrium(1)|lung(2)	3						TAACCTCCACGAGGTGGGAAA	0.498000													5	23					0	0	0.217242	0	0
ACPT	93650	broad.mit.edu	37	19	51297178	51297178	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:51297178C>G	ENST00000270593.1	+	8	812	c.812C>G	c.(811-813)tCc>tGc	p.S271C	ACPT_ENST00000270594.3_Missense_Mutation_p.S178C	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	271						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCAAACTTCTCCCGGGTCCAG	0.587000													26	111					0	0	0.706142	0	0
COPB1	1315	broad.mit.edu	37	11	14479392	14479392	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:14479392G>A	ENST00000249923.3	-	22	3140	c.2840C>T	c.(2839-2841)tCa>tTa	p.S947L	COPB1_ENST00000439561.2_Missense_Mutation_p.S947L	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	947					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TTTCTTCTGTGACAAGTTGAT	0.294000													4	16					0	0	0.150653	0	0
CYP26B1	56603	broad.mit.edu	37	2	72360249	72360249	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:72360249C>T	ENST00000001146.2	-	5	1252	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	CYP26B1_ENST00000412253.1_Missense_Mutation_p.G159E|CYP26B1_ENST00000546307.1_Missense_Mutation_p.G275E	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	350					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						GTAGCGCAGCCCACTGAGCGT	0.642000													12	46					0	0	0.387290	0	0
HID1	283987	broad.mit.edu	37	17	72955115	72955115	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:72955115C>A	ENST00000425042.2	-	9	1117	c.1040G>T	c.(1039-1041)cGg>cTg	p.R347L		NM_030630.2	NP_085133.1			HID1 domain containing																		GGACAGCAGCCGGGCTATACC	0.612000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	33					0.0381472	0.0395985	0.278610	1	0
RYR2	6262	broad.mit.edu	37	1	237941996	237941996	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:237941996G>T	ENST00000366574.2	+	88	12123	c.11806G>T	c.(11806-11808)Gca>Tca	p.A3936S	RYR2_ENST00000542537.1_Missense_Mutation_p.A3920S|RYR2_ENST00000360064.6_Missense_Mutation_p.A3942S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3936					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAGAGTTTGGCACACAGCAG	0.448000													19	51					6.44725e-10	9.4725e-10	0.624587	1	0
COL5A3	50509	broad.mit.edu	37	19	10114363	10114363	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:10114363G>A	ENST00000264828.3	-	6	812	c.727C>T	c.(727-729)Cgt>Tgt	p.R243C		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	243	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CGCCGAGGACGAGGGGTTTCT	0.582000													14	60					0	0	0.479597	0	0
VPS13D	55187	broad.mit.edu	37	1	12333079	12333079	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:12333079C>A	ENST00000358136.3	+	18	2253	c.2123C>A	c.(2122-2124)aCc>aAc	p.T708N	VPS13D_ENST00000356315.4_Missense_Mutation_p.T708N	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	708					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAACGATGGACCGTGCGGCTG	0.428000													26	56					1.12875e-08	1.59108e-08	0.706142	1	0
PASD1	139135	broad.mit.edu	37	X	150840152	150840152	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:150840152C>A	ENST00000370357.4	+	13	1583	c.1338C>A	c.(1336-1338)ctC>ctA	p.L446L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	446						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AGCGGCCTCTCCCACATCCCA	0.498000													35	99					2.80507e-11	4.37362e-11	0.760397	1	0
FER1L6	654463	broad.mit.edu	37	8	125033810	125033810	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:125033810C>A	ENST00000522917.1	+	17	2240	c.2034C>A	c.(2032-2034)gcC>gcA	p.A678A	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.A678A	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	678						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCAAGGAGGCCAAGGGGATCA	0.443000													15	95					6.72482e-11	1.02755e-10	0.479597	1	0
OLIG3	167826	broad.mit.edu	37	6	137815150	137815150	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:137815150C>T	ENST00000367734.2	-	1	381	c.158G>A	c.(157-159)gGg>gAg	p.G53E		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GAGGCTTTCCCCGGGCATCTT	0.617000													19	115					0	0	0.557998	0	0
RNF213	57674	broad.mit.edu	37	17	78320969	78320969	+	Missense_Mutation	SNP	G	G	A	rs76918558		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:78320969G>A	ENST00000582970.1	+	29	8977	c.8834G>A	c.(8833-8835)cGc>cAc	p.R2945H	RNF213_ENST00000508628.2_Missense_Mutation_p.R2994H|RNF213_ENST00000336301.6_Missense_Mutation_p.R1018H	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTGTGTAAGCGCCAGGACAAG	0.532000													5	20					0	0	0.184627	0	0
LRBA	987	broad.mit.edu	37	4	151682995	151682995	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:151682995C>A	ENST00000535741.1	-	35	6058	c.5585G>T	c.(5584-5586)tGg>tTg	p.W1862L	LRBA_ENST00000507224.1_Missense_Mutation_p.W1862L|LRBA_ENST00000510413.1_Missense_Mutation_p.W1862L|LRBA_ENST00000357115.3_Missense_Mutation_p.W1862L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1862						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AGAATTTTGCCACTCCTATAA	0.264000													14	58					1.3612e-06	1.75077e-06	0.479597	1	0
MDM2	4193	broad.mit.edu	37	12	69233396	69233396	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:69233396G>C	ENST00000462284.1	+	11	1563	c.1261G>C	c.(1261-1263)Gaa>Caa	p.E421Q	MDM2_ENST00000299252.4_Missense_Mutation_p.E245Q|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000545204.1_3'UTR|MDM2_ENST00000350057.5_Missense_Mutation_p.E390Q|MDM2_ENST00000258148.7_Missense_Mutation_p.E366Q|MDM2_ENST00000540827.1_Missense_Mutation_p.E220Q|MDM2_ENST00000348801.2_Missense_Mutation_p.E189Q|MDM2_ENST00000360430.2_Missense_Mutation_p.E220Q|MDM2_ENST00000393413.3_Missense_Mutation_p.E142Q|MDM2_ENST00000478070.1_3'UTR|MDM2_ENST00000393410.1_Missense_Mutation_p.E167Q|MDM2_ENST00000258149.5_Missense_Mutation_p.E360Q|MDM2_ENST00000356290.4_Missense_Mutation_p.E245Q|MDM2_ENST00000428863.2_Missense_Mutation_p.E194Q|MDM2_ENST00000517852.1_Missense_Mutation_p.E54Q|MDM2_ENST00000393412.3_Missense_Mutation_p.E142Q	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	415	Necessary for interaction with USP2.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GAAAGAGTTTGAAAGGGAAGA	0.388000			A		"""sarcoma, glioma, colorectal, other"""								15	28					0	0	0.457914	0	0
SPTA1	6708	broad.mit.edu	37	1	158609710	158609710	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:158609710G>C	ENST00000368148.3	-	34	5005	c.4825C>G	c.(4825-4827)Caa>Gaa	p.Q1609E	SPTA1_ENST00000368147.3_Missense_Mutation_p.Q1609E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1609					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AACCTCTGTTGACGACTGGCC	0.463000													42	82					0	0	0.819951	0	0
RAF1	5894	broad.mit.edu	37	3	12645699	12645699	+	Missense_Mutation	SNP	G	G	A	rs80338796		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:12645699G>A	ENST00000251849.4	-	7	1209	c.770C>T	c.(769-771)tCg>tTg	p.S257L	RAF1_ENST00000542177.1_Missense_Mutation_p.S176L|RAF1_ENST00000534997.1_Missense_Mutation_p.S42L|RAF1_ENST00000442415.2_Missense_Mutation_p.S257L	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	257			S -> L (in NS5 and LEOPARD2; shows in vitro greater kinase activity and enhanced ERK activation than wild-type).		activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.S257L(3)|p.S257W(1)	ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	TGTGGATGTCGACCTCTGCCT	0.527000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				28	62					0	0	0.706142	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629708	9629708	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:9629708T>A	ENST00000382492.2	-	1	755	c.437A>T	c.(436-438)aAa>aTa	p.K146I	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	146					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						CCCTGCATATTTGCTATGGAA	0.393000													16	34					0	0	0.479597	0	0
NUP133	55746	broad.mit.edu	37	1	229600529	229600529	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:229600529C>A	ENST00000261396.3	-	18	2484	c.2393G>T	c.(2392-2394)cGa>cTa	p.R798L	NUP133_ENST00000366679.1_Missense_Mutation_p.R798L|NUP133_ENST00000537506.1_Missense_Mutation_p.R782L	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	798					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CACGATGTTTCGGAGGTTGCT	0.493000													19	43					1.64113e-05	1.99654e-05	0.592651	1	0
FRMPD1	22844	broad.mit.edu	37	9	37692734	37692734	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:37692734G>A	ENST00000539465.1	+	2	689	c.96G>A	c.(94-96)tcG>tcA	p.S32S	FRMPD1_ENST00000377765.3_Silent_p.S32S|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	32						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GGGACAGCTCGGCCCGGTAAG	0.547000													4	73					0	0	0.150653	0	0
CACNA1F	778	broad.mit.edu	37	X	49065126	49065126	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:49065126G>T	ENST00000376265.2	-	43	5066	c.5005C>A	c.(5005-5007)Ccc>Acc	p.P1669T	CACNA1F_ENST00000376251.1_Missense_Mutation_p.P1604T|CACNA1F_ENST00000323022.5_Missense_Mutation_p.P1658T	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1669					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CGAGCTGAGGGCTGGGAGACC	0.567000													20	57					9.95505e-16	1.76876e-15	0.624587	1	0
CFAP221	200373	broad.mit.edu	37	2	120383254	120383254	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:120383254G>T	ENST00000602047.1	+	16	1760	c.648G>T	c.(646-648)tcG>tcT	p.S216S	PCDP1_ENST00000413369.3_Silent_p.S502S|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		502						cilium	calmodulin binding	p.S216S(1)				Colorectal(110;0.196)					CAAAACAATCGATAGCACAAG	0.428000													5	17					1.23904e-05	1.52682e-05	0.184627	1	0
NES	10763	broad.mit.edu	37	1	156640547	156640547	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:156640547C>G	ENST00000368223.3	-	4	3565	c.3433G>C	c.(3433-3435)Gag>Cag	p.E1145Q		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1145	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTGCCTCCTCTAGGTCCTTT	0.602000													24	70					0	0	0.624587	0	0
FAT4	79633	broad.mit.edu	37	4	126241834	126241834	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:126241834G>C	ENST00000394329.3	+	1	4281	c.4268G>C	c.(4267-4269)gGa>gCa	p.G1423A		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1423	Cadherin 14.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTTCCTCCTGGAGATATTTTC	0.423000													6	90					0	0	0.307466	0	0
RERGL	79785	broad.mit.edu	37	12	18237467	18237467	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:18237467T>A	ENST00000229002.2	-	5	525	c.319A>T	c.(319-321)Act>Tct	p.T107S	RERGL_ENST00000536890.1_3'UTR|RERGL_ENST00000541632.1_5'UTR|RERGL_ENST00000538724.1_Missense_Mutation_p.T106S	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	107	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						CAATGACTAGTTTGTGGCTCC	0.373000													25	39					0	0	0.681144	0	0
MTPAP	55149	broad.mit.edu	37	10	30653638	30653638	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:30653638C>A	ENST00000358107.4	-	2	543	c.544G>T	c.(544-546)Ggt>Tgt	p.G182C	MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	0					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						TACTCACCACCCTGCTTGTCA	0.647000													7	16					8.12818e-05	9.52444e-05	0.248553	1	0
WSCD1	23302	broad.mit.edu	37	17	6012984	6012984	+	Missense_Mutation	SNP	C	C	G	rs146993898	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:6012984C>G	ENST00000574946.1	+	6	1297	c.907C>G	c.(907-909)Cgg>Ggg	p.R303G	WSCD1_ENST00000539421.1_Missense_Mutation_p.R303G|WSCD1_ENST00000574232.1_Missense_Mutation_p.R303G|WSCD1_ENST00000317744.5_Missense_Mutation_p.R303G|WSCD1_ENST00000573634.1_Missense_Mutation_p.R187G			Q658N2	WSCD1_HUMAN	WSC domain containing 1	303	WSC 2.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						CCCTACCCCCCGGTTCAACCT	0.562000													37	191					0	0	0.804634	0	0
CT47B1	643311	broad.mit.edu	37	X	120009178	120009178	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:120009178G>T	ENST00000371311.3	-	1	601	c.347C>A	c.(346-348)cCg>cAg	p.P116Q		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	116										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCCCGCCGCCGGGTACCGACG	0.637000													27	41					3.6726e-16	6.55577e-16	0.667858	1	0
ZBTB41	360023	broad.mit.edu	37	1	197144219	197144219	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:197144219A>G	ENST00000367405.4	-	8	1974	c.1906T>C	c.(1906-1908)Tgt>Cgt	p.C636R	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	636					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CATTTTCCACATTCTTCACAC	0.338000													21	56					0	0	0.608945	0	0
ZNF251	90987	broad.mit.edu	37	8	145947374	145947374	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:145947374C>A	ENST00000292562.7	-	5	1946	c.1671G>T	c.(1669-1671)tgG>tgT	p.W557C	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TGTGAACTGTCCAGCGCAGAA	0.493000													33	43					2.80507e-11	4.37362e-11	0.760397	1	0
ASPM	259266	broad.mit.edu	37	1	197091620	197091620	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:197091620T>A	ENST00000367409.4	-	14	3752	c.3496A>T	c.(3496-3498)Act>Tct	p.T1166S	ASPM_ENST00000367408.1_Missense_Mutation_p.T416S|ASPM_ENST00000294732.7_Missense_Mutation_p.T1166S	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1166	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ACAGTTTGAGTAGTACGCTGA	0.403000													9	31					0	0	0.335167	0	0
PHEX	5251	broad.mit.edu	37	X	22132685	22132685	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:22132685A>G	ENST00000379374.4	+	11	1848	c.1283A>G	c.(1282-1284)cAg>cGg	p.Q428R	PHEX_ENST00000535894.1_Missense_Mutation_p.Q331R|PHEX_ENST00000537599.1_Missense_Mutation_p.Q428R|PHEX_ENST00000418858.3_Missense_Mutation_p.Q131R	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	428					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						GTGTACTTCCAGGAAGATAAG	0.408000													8	41					0	0	0.278610	0	0
NCALD	83988	broad.mit.edu	37	8	102731625	102731625	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:102731625C>T	ENST00000395923.1	-	4	692	c.233G>A	c.(232-234)gGg>gAg	p.G78E	NCALD_ENST00000519508.2_Missense_Mutation_p.G78E|NCALD_ENST00000311028.3_Missense_Mutation_p.G78E|NCALD_ENST00000522951.1_Missense_Mutation_p.G78E|NCALD_ENST00000521599.1_Missense_Mutation_p.G78E|NCALD_ENST00000220931.6_Missense_Mutation_p.G78E	NM_001040627.1|NM_001040628.1|NM_001040629.1|NM_001040630.1	NP_001035717.1|NP_001035718.1|NP_001035719.1|NP_001035720.1	P61601	NCALD_HUMAN	neurocalcin delta	78	EF-hand 2.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			GTCTATTGTCCCATCTCCATT	0.453000													19	136					0	0	0.539581	0	0
OR51B2	79345	broad.mit.edu	37	11	5345063	5345063	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:5345063C>A	ENST00000328813.2	-	1	519	c.465G>T	c.(463-465)ctG>ctT	p.L155L	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAATTACAGGCAGGATGGATA	0.423000													12	46					0.0931896	0.0959526	0.411799	1	0
ASXL3	80816	broad.mit.edu	37	18	31325198	31325198	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr18:31325198G>T	ENST00000269197.5	+	12	5386	c.5386G>T	c.(5386-5388)Gtt>Ttt	p.V1796F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1796					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AGAGAGAAACGTTGAAATTCC	0.498000													62	100					1.88225e-35	3.64985e-35	0.870114	1	0
KRTAP20-2	337976	broad.mit.edu	37	21	32007602	32007602	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:32007602A>G	ENST00000330798.2	+	1	48	c.20A>G	c.(19-21)tAc>tGc	p.Y7C		NM_181616.1	NP_853647.1	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	7			Y -> H (in dbSNP:rs8132705).			intermediate filament				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|ovary(1)	8						TACAGCAACTACTATGGTGGT	0.522000													39	64					0	0	0.812448	0	0
DMD	1756	broad.mit.edu	37	X	32481653	32481653	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:32481653C>A	ENST00000357033.4	-	25	3541	c.3335G>T	c.(3334-3336)gGg>gTg	p.G1112V	DMD_ENST00000378677.2_Missense_Mutation_p.G1108V	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1112					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TATCTTCTGCCCACCTTCATT	0.388000													4	7					0.00909568	0.0095982	0.150653	1	0
PCDHA6	56142	broad.mit.edu	37	5	140210056	140210056	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:140210056G>C	ENST00000529310.1	+	1	2494	c.2380G>C	c.(2380-2382)Gat>Cat	p.D794H	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTAAATGAAGATCATGATGC	0.358000													26	49					0	0	0.667858	0	0
NOTCH2	4853	broad.mit.edu	37	1	120491110	120491110	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:120491110G>T	ENST00000256646.2	-	17	2898	c.2679C>A	c.(2677-2679)ggC>ggA	p.G893G		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	893	EGF-like 23; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATGTAGCTGCCCTGGGTGT	0.517000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome		OREG0013733	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	70					4.68919e-08	6.42032e-08	0.361761	1	0
MAGEC3	139081	broad.mit.edu	37	X	140984900	140984900	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:140984900C>A	ENST00000298296.1	+	7	1356	c.1356C>A	c.(1354-1356)ccC>ccA	p.P452P	MAGEC3_ENST00000409007.1_Silent_p.P154P|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000536088.1_Silent_p.P154P|MAGEC3_ENST00000544766.1_Silent_p.P154P|MAGEC3_ENST00000443323.2_Silent_p.P74P	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	452										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					AATCCTTGCCCAGGTATGCCC	0.502000													28	43					1.04121e-07	1.40545e-07	0.693898	1	0
CABIN1	23523	broad.mit.edu	37	22	24483438	24483438	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:24483438G>T	ENST00000398319.2	+	23	3682	c.3297G>T	c.(3295-3297)cgG>cgT	p.R1099R	CABIN1_ENST00000263119.5_Silent_p.R1099R|CABIN1_ENST00000405822.2_Silent_p.R1049R	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1099					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CTCTGGCCCGGGCCAGCCGCA	0.537000													10	39					4.68919e-08	6.42032e-08	0.361761	1	0
CTDSP2	10106	broad.mit.edu	37	12	58217755	58217755	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:58217755T>A	ENST00000398073.2	-	7	925	c.622A>T	c.(622-624)Agg>Tgg	p.R208W	CTDSP2_ENST00000548823.1_Intron|CTDSP2_ENST00000547701.1_Missense_Mutation_p.R56W	NM_005730.3	NP_005721.3	O14595	CTDS2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	208	FCP1 homology.				protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					CTCAGGTCCCTCCCCAGGCGG	0.607000													5	37					0	0	0.184627	0	0
SST	6750	broad.mit.edu	37	3	187386921	187386921	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:187386921C>G	ENST00000287641.3	-	2	390	c.283G>C	c.(283-285)Gct>Cct	p.A95P		NM_001048.3	NP_001039.1	P61278	SMS_HUMAN	somatostatin	95					digestion|G-protein coupled receptor protein signaling pathway|induction of apoptosis by hormones|negative regulation of cell proliferation|response to nutrient|synaptic transmission	extracellular space	hormone activity			kidney(1)|large_intestine(1)|lung(6)|pancreas(1)	9	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.00444)	Bromocriptine(DB01200)|Cysteamine(DB00847)	GGTGCCATAGCCGGGTTTGAG	0.493000													27	199					0	0	0.681144	0	0
DNAH17	8632	broad.mit.edu	37	17	76547658	76547658	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:76547658T>A	ENST00000389840.5	-	16	2474	c.2350A>T	c.(2350-2352)Aag>Tag	p.K784*	DNAH17_ENST00000585328.1_Nonsense_Mutation_p.K784*					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGTTTTGCCTTTTGCATCCTG	0.468000													23	66					0	0	0.639603	0	0
GRM8	2918	broad.mit.edu	37	7	126883250	126883250	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:126883250G>T	ENST00000339582.2	-	2	817	c.9C>A	c.(7-9)tgC>tgA	p.C3*	GRM8_ENST00000358373.3_Nonsense_Mutation_p.C3*|GRM8_ENST00000405249.1_Nonsense_Mutation_p.C3*|GRM8_ENST00000444921.2_Nonsense_Mutation_p.C3*			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	3					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCTTTCCCTCGCATACCATTT	0.498000										HNSCC(24;0.065)	OREG0003802	type=REGULATORY REGION|Gene=GRM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	16	43					1.5739e-10	2.36704e-10	0.500413	1	0
MALAT1	378938	broad.mit.edu	37	11	65266463	65266463	+	RNA	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:65266463G>T	ENST00000534336.1	+	0	1231					NR_002819.2																						ATCGAATTCCGGTGATGCGAG	0.512000													18	73					2.94398e-08	4.07464e-08	0.557998	1	0
EBF1	1879	broad.mit.edu	37	5	158523367	158523367	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:158523367C>A	ENST00000313708.6	-	3	621	c.339G>T	c.(337-339)caG>caT	p.Q113H	EBF1_ENST00000380654.4_Missense_Mutation_p.Q113H|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Missense_Mutation_p.Q113H	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	113					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTAGAGAAGCTGAAGCCGGT	0.592000			T	HMGA2	lipoma								8	19					0.0381472	0.0395985	0.278610	1	0
TMEM105	284186	broad.mit.edu	37	17	79287590	79287590	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:79287590T>G	ENST00000332900.1	-	3	800	c.251A>C	c.(250-252)cAt>cCt	p.H84P		NM_178520.3	NP_848615.1	Q8N8V8	TM105_HUMAN	transmembrane protein 105	84						integral to membrane				NS(1)|large_intestine(3)|lung(1)|ovary(2)	7	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			AGGCCCTTCATGTCTTCGCCT	0.652000													18	114					0	0	0.539581	0	0
MEGF10	84466	broad.mit.edu	37	5	126792966	126792966	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:126792966G>T	ENST00000274473.6	+	26	3646	c.3379G>T	c.(3379-3381)Gac>Tac	p.D1127Y	MEGF10_ENST00000503335.2_Missense_Mutation_p.D1127Y	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	1127	Necessary for formation of large intracellular vacuoles.|Ser-rich.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TAAGCAAGAGGACAGTGGTGG	0.527000													23	57					5.26018e-13	8.85193e-13	0.608945	1	0
OTOF	9381	broad.mit.edu	37	2	26691279	26691279	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:26691279C>A	ENST00000272371.2	-	33	4213	c.4087G>T	c.(4087-4089)Gag>Tag	p.E1363*	OTOF_ENST00000338581.6_Nonsense_Mutation_p.E596*|OTOF_ENST00000403946.3_Nonsense_Mutation_p.E1363*|OTOF_ENST00000339598.3_Nonsense_Mutation_p.E596*|OTOF_ENST00000402415.3_Nonsense_Mutation_p.E673*	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1363					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTCACCCTCGGTATTGTCC	0.562000													7	58					1.06961e-07	1.43366e-07	0.278610	1	0
C18orf8	29919	broad.mit.edu	37	18	21109655	21109655	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr18:21109655C>T	ENST00000269221.3	+	16	1583	c.1473C>T	c.(1471-1473)aaC>aaT	p.N491N	C18orf8_ENST00000591367.1_3'UTR|C18orf8_ENST00000590868.1_Silent_p.N443N	NM_013326.3	NP_037458.3	Q96DM3	MIC1_HUMAN	chromosome 18 open reading frame 8	491	Mic1.									endometrium(9)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	21	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTTCTCTTAACCAGTTTCAGA	0.388000													15	101					0	0	0.479597	0	0
CATSPERD	257062	broad.mit.edu	37	19	5776215	5776215	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:5776215G>T	ENST00000381624.3	+	21	2046	c.1985G>T	c.(1984-1986)aGg>aTg	p.R662M	CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	662						integral to membrane											GCCCCTTTGAGGTGGCCAGAC	0.562000													19	59					6.49762e-13	1.08864e-12	0.539581	1	0
CUL4A	8451	broad.mit.edu	37	13	113897418	113897418	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr13:113897418A>G	ENST00000451881.1	+	11	1121	c.872A>G	c.(871-873)aAg>aGg	p.K291R	CUL4A_ENST00000375440.4_Missense_Mutation_p.K391R|CUL4A_ENST00000375441.3_Missense_Mutation_p.K291R|CUL4A_ENST00000326335.4_Missense_Mutation_p.K291R	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	391					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			AACCTGATGAAGGAGTCCTTT	0.443000													23	43					0	0	0.667858	0	0
OR10C1	442194	broad.mit.edu	37	6	29408489	29408489	+	Missense_Mutation	SNP	C	C	T	rs147036236	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:29408489C>T	ENST00000444197.2	+	1	1407	c.697C>T	c.(697-699)Cgc>Tgc	p.R233C	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGTTGCGGGCCGCCGCAAGGC	0.592000													40	215					0	0	0.827153	0	0
ZFAND1	79752	broad.mit.edu	37	8	82626216	82626216	+	Silent	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:82626216T>A	ENST00000220669.5	-	6	435	c.417A>T	c.(415-417)acA>acT	p.T139T	ZFAND1_ENST00000521287.1_Silent_p.T32T|ZFAND1_ENST00000522520.1_Silent_p.T32T|ZFAND1_ENST00000521895.1_Silent_p.T32T|ZFAND1_ENST00000519523.1_Silent_p.T139T|ZFAND1_ENST00000517588.1_Silent_p.T32T|ZFAND1_ENST00000523096.1_Silent_p.T139T	NM_024699.2	NP_078975.2	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	139							zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						CCTTTGCAGCTGTTTCACTAT	0.348000													6	34					0	0	0.217242	0	0
ITPRIPL2	162073	broad.mit.edu	37	16	19126972	19126972	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:19126972C>T	ENST00000381440.3	+	1	1719	c.1189C>T	c.(1189-1191)Cag>Tag	p.Q397*	CTD-2349B8.1_ENST00000564808.2_Intron	NM_001034841.3	NP_001030013.1	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 2	397						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						GGCCGCCACCCAGTGGGGACG	0.657000													56	208					0	0	0.870114	0	0
OR52K2	119774	broad.mit.edu	37	11	4470638	4470638	+	Silent	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:4470638A>G	ENST00000325719.4	+	1	114	c.69A>G	c.(67-69)gaA>gaG	p.E23E		NM_001005172.2	NP_001005172.2	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|skin(6)	25		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGCCTGGAACACCTGCACA	0.517000													38	64					0	0	0.812448	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382566.1_3'UTR	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	41					0	0	0.278610	0	0
VCAM1	7412	broad.mit.edu	37	1	101194697	101194697	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:101194697C>T	ENST00000294728.2	+	5	1064	c.963C>T	c.(961-963)ccC>ccT	p.P321P	VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000370119.4_Silent_p.P259P|VCAM1_ENST00000347652.2_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	321	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CCCCTGGACCCCGGATTGCTG	0.453000													48	118					0	0	0.870114	0	0
TFEC	22797	broad.mit.edu	37	7	115624467	115624467	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:115624467G>T	ENST00000265440.7	-	2	209	c.29C>A	c.(28-30)cCa>cAa	p.P10Q	TFEC_ENST00000393485.1_Missense_Mutation_p.P10Q|TFEC_ENST00000484212.1_Missense_Mutation_p.P100Q|TFEC_ENST00000320239.7_Missense_Mutation_p.P10Q	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	10	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TTTAAGAGTTGGATTGATGAT	0.498000													32	80					1.39806e-14	2.43862e-14	0.729181	1	0
OR2H1	26716	broad.mit.edu	37	6	29430484	29430484	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:29430484G>T	ENST00000377136.1	+	4	1403	c.938G>T	c.(937-939)tGg>tTg	p.W313L	OR2H1_ENST00000377133.1_Missense_Mutation_p.W313L|OR2H1_ENST00000377132.1_Missense_Mutation_p.W313L|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000442615.1_Missense_Mutation_p.W313L|OR2H1_ENST00000396792.2_Missense_Mutation_p.W313L			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						AGGGAAAGCTGGAGAGCTGCT	0.433000													14	41					4.36969e-10	6.46985e-10	0.435327	1	0
MUC16	94025	broad.mit.edu	37	19	9059529	9059529	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:9059529C>A	ENST00000397910.4	-	3	28120	c.27917G>T	c.(27916-27918)aGc>aTc	p.S9306I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9308	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGACAGTGCTTTTTTCTGT	0.507000													10	139					2.80697e-09	4.00099e-09	0.387290	1	0
NDST3	9348	broad.mit.edu	37	4	119163305	119163305	+	Splice_Site	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:119163305G>T	ENST00000296499.5	+	12	2802		c.e12+1			NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						AAGCTTTAACGTAAGTTTATA	0.343000													13	47					4.3838e-07	5.7154e-07	0.435327	1	0
PLXNC1	10154	broad.mit.edu	37	12	94649046	94649046	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:94649046T>C	ENST00000258526.4	+	17	3310	c.3061T>C	c.(3061-3063)Ttt>Ctt	p.F1021L	PLXNC1_ENST00000547057.1_Missense_Mutation_p.F68L	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1021					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTACAAACATTTTGCTCTGAG	0.403000													5	24					0	0	0.184627	0	0
MUC16	94025	broad.mit.edu	37	19	9047883	9047883	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:9047883C>A	ENST00000397910.4	-	5	33951	c.33748G>T	c.(33748-33750)Gtt>Ttt	p.V11250F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11252	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAAGTTGGAACAACAGAACTT	0.483000													6	31					0.00116845	0.0012863	0.217242	1	0
FTCD	10841	broad.mit.edu	37	21	47571593	47571593	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:47571593C>A	ENST00000397748.1	-	5	558	c.515G>T	c.(514-516)gGg>gTg	p.G172V	FTCD_ENST00000291670.5_Missense_Mutation_p.G172V|FTCD_ENST00000359679.2_Missense_Mutation_p.G172V|FTCD-AS1_ENST00000446649.1_RNA|FTCD_ENST00000397746.3_Missense_Mutation_p.G172V|FTCD_ENST00000355384.2_Missense_Mutation_p.G172V|FTCD_ENST00000397743.1_Missense_Mutation_p.G172V|FTCD_ENST00000498355.2_5'UTR			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	172	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GGCCGTGGCCCCCCAACTGGG	0.637000													11	61					0.00136819	0.00149756	0.411799	1	0
CDK16	5127	broad.mit.edu	37	X	47083104	47083104	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:47083104C>T	ENST00000457458.2	+	2	586	c.166C>T	c.(166-168)Cgt>Tgt	p.R56C	CDK16_ENST00000518022.1_Missense_Mutation_p.R50C|CDK16_ENST00000276052.6_Missense_Mutation_p.R124C|CDK16_ENST00000357227.4_Missense_Mutation_p.R50C	NM_033018.3	NP_148978.2	Q00536	CDK16_HUMAN	cyclin-dependent kinase 16	50							ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)	11						GGCCCCCACACGTGCTGCTCC	0.637000													3	23					0	0	0.115264	0	0
ZNF304	57343	broad.mit.edu	37	19	57867973	57867973	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:57867973G>C	ENST00000391705.3	+	4	1020	c.736G>C	c.(736-738)Gct>Cct	p.A246P	ZNF304_ENST00000443917.2_Missense_Mutation_p.A293P|ZNF304_ENST00000282286.5_Missense_Mutation_p.A246P|ZNF304_ENST00000598744.1_Missense_Mutation_p.A204P	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A246P(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GATGACTCATGCTGAGGTGAG	0.443000													14	46					0	0	0.457914	0	0
KANK4	163782	broad.mit.edu	37	1	62703954	62703954	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:62703954G>T	ENST00000371153.4	-	10	3361	c.2983C>A	c.(2983-2985)Ctg>Atg	p.L995M	KANK4_ENST00000354381.3_Missense_Mutation_p.L367M|KANK4_ENST00000371150.1_Missense_Mutation_p.L351M|KANK4_ENST00000317477.4_Missense_Mutation_p.L133M	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	995										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						AGCCCCTACAGCCCCAGGGAC	0.617000													8	40					6.5536e-12	1.06079e-11	0.278610	1	0
ADAM7	8756	broad.mit.edu	37	8	24299997	24299997	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:24299997C>A	ENST00000175238.6	+	2	147	c.64C>A	c.(64-66)Ctt>Att	p.L22I	ADAM7_ENST00000380789.1_Missense_Mutation_p.L22I|ADAM7_ENST00000441335.2_Missense_Mutation_p.L22I|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	22					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		AAAGTTCATCCTTGGAGTAGA	0.408000													14	140					2.62699e-14	4.54077e-14	0.479597	1	0
DNAH8	1769	broad.mit.edu	37	6	38818077	38818077	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:38818077G>A	ENST00000359357.3	+	36	4853	c.4599G>A	c.(4597-4599)caG>caA	p.Q1533Q	DNAH8_ENST00000449981.2_Silent_p.Q1750Q|DNAH8_ENST00000441566.1_Silent_p.Q1533Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAATAATGCAGCGAGCTCATG	0.363000													18	40					0	0	0.557998	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273189	145273189	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:145273189C>G	ENST00000369340.3	+	4	487	c.43C>G	c.(43-45)Cca>Gca	p.P15A	RP11-458D21.5_ENST00000468030.1_Missense_Mutation_p.P15A|NOTCH2NL_ENST00000362074.6_Missense_Mutation_p.P15A|NOTCH2NL_ENST00000344859.3_Missense_Mutation_p.P15A			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	15	EGF-like 1.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						ATACAGATGTCCAGAAGGCTT	0.463000													10	108					0	0	0.500413	0	0
CEP192	55125	broad.mit.edu	37	18	13087146	13087146	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr18:13087146G>T	ENST00000506447.1	+	31	5827	c.5747G>T	c.(5746-5748)cGc>cTc	p.R1916L	CEP192_ENST00000430049.2_Missense_Mutation_p.R1441L|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000325971.8_Missense_Mutation_p.R1320L	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1511										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTTTCTGTCCGCAACACTGGC	0.363000													15	52					1.02788e-11	1.6498e-11	0.520397	1	0
AMDHD2	51005	broad.mit.edu	37	16	2578487	2578487	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:2578487G>T	ENST00000302956.4	+	8	991	c.897G>T	c.(895-897)ttG>ttT	p.L299F	CEMP1_ENST00000382350.1_Intron|AMDHD2_ENST00000565570.1_Intron|AMDHD2_ENST00000293971.6_Missense_Mutation_p.L299F|AMDHD2_ENST00000413459.3_Missense_Mutation_p.L299F			Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2	299					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						TCCCTGCCTTGGGCCTGGGCA	0.667000													6	43					0.00116845	0.0012863	0.217242	1	0
MAP3K10	4294	broad.mit.edu	37	19	40711891	40711891	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:40711891G>T	ENST00000253055.3	+	5	1550	c.1262G>T	c.(1261-1263)cGg>cTg	p.R421L		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	421	Leucine-zipper 2.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CAGCTGCGGCGGCGGGAGCAG	0.687000													3	20					6.4e-05	7.54734e-05	0.115264	1	0
ATF2	1386	broad.mit.edu	37	2	175983089	175983089	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:175983089G>A	ENST00000264110.2	-	6	506	c.208C>T	c.(208-210)Cca>Tca	p.P70S	ATF2_ENST00000392544.1_Missense_Mutation_p.P70S|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000345739.5_Missense_Mutation_p.P12S|ATF2_ENST00000409437.1_Missense_Mutation_p.P52S|ATF2_ENST00000409635.1_Missense_Mutation_p.P12S|ATF2_ENST00000426833.3_Missense_Mutation_p.P52S|ATF2_ENST00000409833.1_Missense_Mutation_p.P70S|ATF2_ENST00000538946.1_Missense_Mutation_p.P52S|ATF2_ENST00000487334.2_Missense_Mutation_p.P52S|ATF2_ENST00000392543.2_Intron	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	70					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			GTTGGTGTTGGGGTCTGATCT	0.333000													6	19					0	0	0.217242	0	0
ZAN	7455	broad.mit.edu	37	7	100390129	100390129	+	RNA	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:100390129C>A	ENST00000542585.1	+	0	7960				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGGAGGCGGGCGCTGCCCTGG	0.672000													10	24					4.68919e-08	6.42032e-08	0.361761	1	0
EMR1	2015	broad.mit.edu	37	19	6919615	6919615	+	Missense_Mutation	SNP	C	C	T	rs144318055		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:6919615C>T	ENST00000312053.4	+	13	1514	c.1477C>T	c.(1477-1479)Cgc>Tgc	p.R493C	EMR1_ENST00000250572.8_Missense_Mutation_p.R493C|EMR1_ENST00000381407.5_Missense_Mutation_p.R352C|EMR1_ENST00000381404.4_Missense_Mutation_p.R441C|EMR1_ENST00000450315.3_Missense_Mutation_p.R316C	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	493	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TTTAAATGAGCGCTTCTTCAA	0.473000													25	85					0	0	0.693898	0	0
ELMO1	9844	broad.mit.edu	37	7	36895295	36895295	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:36895295G>A	ENST00000310758.4	-	22	2692	c.2045C>T	c.(2044-2046)aCg>aTg	p.T682M	ELMO1_ENST00000396040.2_Missense_Mutation_p.T202M|ELMO1_ENST00000442504.1_Missense_Mutation_p.T682M|ELMO1_ENST00000448602.1_Missense_Mutation_p.T682M|ELMO1_ENST00000341056.3_Missense_Mutation_p.T384M|ELMO1_ENST00000396045.3_Missense_Mutation_p.T202M	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	682					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						GTCATTCCGCGTCAGGTCGCT	0.572000													34	91					0	0	0.760397	0	0
BMP3	651	broad.mit.edu	37	4	81974526	81974526	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:81974526A>G	ENST00000282701.2	+	3	1575	c.1255A>G	c.(1255-1257)Atc>Gtc	p.I419V		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	419					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						TCATGCTACCATCCAGAGTAT	0.433000													33	91					0	0	0.779181	0	0
LILRA4	23547	broad.mit.edu	37	19	54849342	54849342	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:54849342C>A	ENST00000291759.4	-	4	576	c.520G>T	c.(520-522)Gga>Tga	p.G174*		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	174	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TGGAACTTTCCATGGTTGTGT	0.572000													3	38					0.115264	0.117416	0.115264	1	0
IRS4	8471	broad.mit.edu	37	X	107979005	107979005	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:107979005C>A	ENST00000372129.2	-	1	646	c.570G>T	c.(568-570)tgG>tgT	p.W190C		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	190	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GCAGCAAGTACCAGCTTTCCT	0.662000													14	42					1.05317e-09	1.51816e-09	0.457914	1	0
CGA	1081	broad.mit.edu	37	6	87797884	87797884	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:87797884A>G	ENST00000369582.2	-	2	135	c.35T>C	c.(34-36)cTg>cCg	p.L12P		NM_000735.3	NP_000726.1	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	12					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)	15		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		CAATGTGACCAGAAAGATAGC	0.398000													4	10					0	0	0.184627	0	0
FCRL5	83416	broad.mit.edu	37	1	157508895	157508895	+	Silent	SNP	C	C	A	rs139032379	byFrequency	TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:157508895C>A	ENST00000361835.3	-	7	1540	c.1383G>T	c.(1381-1383)gcG>gcT	p.A461A	FCRL5_ENST00000356953.4_Silent_p.A461A|FCRL5_ENST00000368190.3_Silent_p.A461A|FCRL5_ENST00000368191.3_Silent_p.A376A|FCRL5_ENST00000368189.3_Silent_p.A461A	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	461	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGAGGCTCACCGCCTTACTGC	0.582000													15	43					2.31682e-05	2.7831e-05	0.479597	1	0
FRMPD2	143162	broad.mit.edu	37	10	49450362	49450362	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:49450362G>A	ENST00000374201.3	-	5	711	c.409C>T	c.(409-411)Ctg>Ttg	p.L137L	FRMPD2_ENST00000407470.4_Silent_p.L106L|FRMPD2_ENST00000305531.3_Silent_p.L113L	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	137	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		ATGGTCAGCAGGATGGAGTGC	0.612000													20	61					0	0	0.592651	0	0
ZNF350	59348	broad.mit.edu	37	19	52472344	52472344	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:52472344C>T	ENST00000243644.4	-	3	283	c.56G>A	c.(55-57)tGg>tAg	p.W19*	HCCAT3_ENST00000595010.1_RNA|ZNF350_ENST00000600703.1_5'UTR|HCCAT3_ENST00000600253.1_RNA	NM_021632.3	NP_067645.3	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	19	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		CCACTCCTCCCAAGTGAAGTC	0.493000													33	95					0	0	0.760397	0	0
CD226	10666	broad.mit.edu	37	18	67613982	67613982	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr18:67613982C>A	ENST00000280200.4	-	3	638	c.370G>T	c.(370-372)Gtg>Ttg	p.V124L	CD226_ENST00000577287.1_5'UTR|CD226_ENST00000582621.1_Missense_Mutation_p.V124L|CD226_ENST00000581982.1_Intron	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	124	Ig-like C2-type 1.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				GACTGAACCACCTGTATCACC	0.383000													9	38					0.000673444	0.000756634	0.361761	1	0
SNX24	28966	broad.mit.edu	37	5	122281823	122281823	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:122281823A>T	ENST00000261369.4	+	3	403	c.218A>T	c.(217-219)cAg>cTg	p.Q73L	SNX24_ENST00000506996.1_Missense_Mutation_p.Q73L|SNX24_ENST00000395451.4_Missense_Mutation_p.Q106L|SNX24_ENST00000513881.1_Missense_Mutation_p.Q73L|SNX24_ENST00000511211.1_3'UTR	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	73	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		GTCTTGGAACAGCGACGACAA	0.338000													12	27					0	0	0.457914	0	0
PRKX	5613	broad.mit.edu	37	X	3533931	3533931	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:3533931G>A	ENST00000262848.5	-	7	1230	c.876C>T	c.(874-876)aaC>aaT	p.N292N	PRKX_ENST00000425240.1_5'UTR	NM_005044.4	NP_005035.1	P51817	PRKX_HUMAN	protein kinase, X-linked	292	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CATTCGCCCCGTTCTTCAAAA	0.433000													6	18					0	0	0.248553	0	0
CRMP1	1400	broad.mit.edu	37	4	5837717	5837717	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:5837717G>T	ENST00000324989.7	-	11	1636	c.1548C>A	c.(1546-1548)gcC>gcA	p.A516A	CRMP1_ENST00000397890.2_Silent_p.A402A|CRMP1_ENST00000512574.1_Silent_p.A400A|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	402					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CCGAGCCCACGGCAATCCGCC	0.527000													30	90					8.16721e-17	1.47164e-16	0.750413	1	0
APLF	200558	broad.mit.edu	37	2	68804988	68804988	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:68804988G>T	ENST00000303795.4	+	10	1541	c.1370G>T	c.(1369-1371)gGg>gTg	p.G457V	APLF_ENST00000471727.1_3'UTR	NM_173545.2	NP_775816.1	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	457					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	25						GATAATGTTGGGCAACCCAAT	0.413000													10	47					0.00621372	0.00663028	0.335167	1	0
ACVR1C	130399	broad.mit.edu	37	2	158390505	158390505	+	Silent	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr2:158390505T>A	ENST00000243349.7	-	9	1767	c.1407A>T	c.(1405-1407)ggA>ggT	p.G469G	ACVR1C_ENST00000335450.7_Silent_p.G389G|ACVR1C_ENST00000409680.3_Silent_p.G419G|ACVR1C_ENST00000348328.5_Silent_p.G312G	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	469	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						GGCGGGCCGCTCCGTTGGCAT	0.383000													17	47					0	0	0.592651	0	0
ZNF578	147660	broad.mit.edu	37	19	53013918	53013918	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:53013918G>T	ENST00000421239.2	+	6	528	c.284G>T	c.(283-285)aGt>aTt	p.S95I		NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AGACATGAAAGTTATCACACT	0.393000													30	111					9.80776e-20	1.80993e-19	0.706142	1	0
ZNF714	148206	broad.mit.edu	37	19	21300752	21300752	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:21300752G>C	ENST00000596143.1	+	5	1607	c.1282G>C	c.(1282-1284)Gaa>Caa	p.E428Q	ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						CAAATGTGAAGAATGTGGCAA	0.368000													12	22					0	0	0.411799	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139896	55139896	+	Splice_Site	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:55139896C>A	ENST00000257290.5	+	10	1888	c.1558_splice	c.e10+1	p.P519_splice	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	519					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGGTGGCTCCCAGTGAGTTCC	0.547000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			15	47					0.00244969	0.00265094	0.457914	1	0
PML	5371	broad.mit.edu	37	15	74326883	74326883	+	Silent	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:74326883A>G	ENST00000435786.2	+	7	1791	c.1722A>G	c.(1720-1722)ccA>ccG	p.P574P	PML_ENST00000268058.3_Intron|PML_ENST00000395135.3_Intron|PML_ENST00000563500.1_3'UTR|PML_ENST00000436891.3_Intron|PML_ENST00000268059.6_Intron|PML_ENST00000395132.2_Intron|PML_ENST00000354026.6_Intron|PML_ENST00000564428.1_Intron|PML_ENST00000569965.1_Intron|PML_ENST00000569477.1_Intron|PML_ENST00000567543.1_3'UTR|PML_ENST00000359928.4_Intron|PML_ENST00000565898.1_Intron	NM_033240.2	NP_150243.2	P29590	PML_HUMAN	promyelocytic leukemia	573					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						TGAGTGGCCCAGAAGTTCAGC	0.582000			T	"""RARA, PAX5"""	"""APL, ALL"""								22	67					0	0	0.592651	0	0
OR52J3	119679	broad.mit.edu	37	11	5068235	5068235	+	Silent	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:5068235C>G	ENST00000380370.1	+	1	480	c.480C>G	c.(478-480)ccC>ccG	p.P160P		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTACACTTCCCATGGTCTATC	0.463000													17	59					0	0	0.500413	0	0
EEF2	1938	broad.mit.edu	37	19	3979429	3979429	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:3979429G>A	ENST00000309311.6	-	11	1699	c.1611C>T	c.(1609-1611)atC>atT	p.I537I		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	537						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCCTCGATGATGCACTGAA	0.637000													34	78					0	0	0.779181	0	0
THRA	7067	broad.mit.edu	37	17	38240933	38240933	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:38240933G>T	ENST00000450525.2	+	6	932	c.441G>T	c.(439-441)aaG>aaT	p.K147N	THRA_ENST00000394121.4_Missense_Mutation_p.K147N|THRA_ENST00000264637.4_Missense_Mutation_p.K147N|THRA_ENST00000546243.1_Missense_Mutation_p.K147N|THRA_ENST00000584985.1_Missense_Mutation_p.K147N	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	147					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GGCGGCGGAAGGAGGAGATGA	0.587000													79	95					1.91123e-38	3.76334e-38	0.870114	1	0
CROCC	9696	broad.mit.edu	37	1	17296381	17296381	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:17296381G>T	ENST00000375541.5	+	33	5472	c.5403G>T	c.(5401-5403)ctG>ctT	p.L1801L		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1801					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGGCTGACCTGGAACTGCAGC	0.662000													14	45					1.05317e-09	1.51816e-09	0.457914	1	0
PPP1R16B	26051	broad.mit.edu	37	20	37546959	37546959	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:37546959G>C	ENST00000299824.1	+	11	1543	c.1354G>C	c.(1354-1356)Gac>Cac	p.D452H	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.D410H	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	452					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				TGAGGTGCCTGACTACAGCAT	0.622000													52	151					0	0	0.870114	0	0
PRRC2C	23215	broad.mit.edu	37	1	171510393	171510393	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:171510393G>T	ENST00000367742.3	+	16	4030	c.3788G>T	c.(3787-3789)cGg>cTg	p.R1263L	PRRC2C_ENST00000426496.2_Missense_Mutation_p.R1261L|PRRC2C_ENST00000338920.4_Missense_Mutation_p.R1261L|PRRC2C_ENST00000392078.3_Missense_Mutation_p.R1263L			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1261							protein C-terminus binding										AGACGACAGCGGGGTTCAGAG	0.473000													11	44					6.40141e-05	7.54734e-05	0.387290	1	0
ABCC12	94160	broad.mit.edu	37	16	48142350	48142350	+	Splice_Site	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr16:48142350C>T	ENST00000311303.3	-	17	2717		c.e17+1		ABCC12_ENST00000448542.1_Splice_Site|ABCC12_ENST00000416054.1_Splice_Site	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12							integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TTATACTGAACCTCCAGAAGC	0.388000													13	35					0	0	0.411799	0	0
NR5A1	2516	broad.mit.edu	37	9	127262971	127262971	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:127262971C>T	ENST00000373588.4	-	4	464	c.268G>A	c.(268-270)Ggt>Agt	p.G90S		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	90					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						TTCCGGCCACCCCTCATACGG	0.612000													18	49					0	0	0.575678	0	0
AXL	558	broad.mit.edu	37	19	41727831	41727831	+	Silent	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:41727831C>T	ENST00000301178.4	+	4	646	c.456C>T	c.(454-456)gcC>gcT	p.A152A	AXL_ENST00000594880.1_3'UTR|CTD-2195B23.3_ENST00000598541.1_RNA|AXL_ENST00000359092.3_Silent_p.A152A	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	152	Ig-like C2-type 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CTGTGGCCGCCAACACCCCCT	0.662000													4	27					0	0	0.184627	0	0
CXorf22	170063	broad.mit.edu	37	X	35970075	35970075	+	Silent	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:35970075C>A	ENST00000297866.5	+	6	1107	c.1041C>A	c.(1039-1041)acC>acA	p.T347T		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	347										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTTGTTTCACCCCAAAGTAAG	0.259000													9	54					1.33987e-11	2.13263e-11	0.361761	1	0
ASB9	140462	broad.mit.edu	37	X	15287938	15287938	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:15287938G>T	ENST00000546332.1	-	2	542	c.59C>A	c.(58-60)cCt>cAt	p.P20H	ASB9_ENST00000380488.4_Missense_Mutation_p.P20H|ASB9_ENST00000380483.3_Missense_Mutation_p.P20H|ASB9_ENST00000380485.3_Missense_Mutation_p.P20H|ASB9_ENST00000473862.1_5'UTR	NM_001168531.1	NP_001162003.1	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box containing 9	20					intracellular signal transduction					breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(10)	15	Hepatocellular(33;0.183)					CCTGATGCCAGGAAAGTCCCT	0.577000													18	70					1.28384e-07	1.70287e-07	0.608945	1	0
UTP14A	10813	broad.mit.edu	37	X	129059173	129059173	+	Splice_Site	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:129059173T>A	ENST00000394422.3	+	12	1777		c.e12+2		UTP14A_ENST00000371051.5_Splice_Site|UTP14A_ENST00000371042.3_Splice_Site|RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Splice_Site	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)						rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						GAGGAGCTGGTGAGCAGAGCC	0.483000													34	101					0	0	0.760397	0	0
OR13F1	138805	broad.mit.edu	37	9	107267317	107267317	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:107267317G>T	ENST00000334726.2	+	1	863	c.774G>T	c.(772-774)atG>atT	p.M258I		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTCTCTCCATGCACCTGAAGC	0.478000													25	62					2.98393e-07	3.91705e-07	0.639603	1	0
SOBP	55084	broad.mit.edu	37	6	107955481	107955481	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:107955481C>A	ENST00000317357.5	+	6	2092	c.1433C>A	c.(1432-1434)cCg>cAg	p.P478Q		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	478	Pro-rich.						metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CTGCTGCCCCCGCCGCCTCCG	0.706000													5	12					0.000602214	0.000678601	0.184627	1	0
EPHA6	285220	broad.mit.edu	37	3	97356759	97356759	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:97356759C>T	ENST00000389672.5	+	14	2655	c.2617C>T	c.(2617-2619)Ctc>Ttc	p.L873F	EPHA6_ENST00000442602.2_3'UTR|EPHA6_ENST00000502694.1_Missense_Mutation_p.L265F|EPHA6_ENST00000514100.1_Missense_Mutation_p.L265F	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	778	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GGTCGGAATGCTCCGAGGCAT	0.428000													43	79					0	0	0.853193	0	0
CETN2	1069	broad.mit.edu	37	X	151998262	151998262	+	Silent	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:151998262G>T	ENST00000370277.3	-	2	112	c.46C>A	c.(46-48)Cga>Aga	p.R16R		NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	16	Required for self-assembly.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					ATTCTTTTTCGCTGAGAACTT	0.408000								Direct reversal of damage;Nucleotide excision repair (NER)					24	67					5.35356e-11	8.21309e-11	0.639603	1	0
KCNA6	3742	broad.mit.edu	37	12	4919702	4919702	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:4919702G>T	ENST00000433855.1	+	1	1361	c.495G>T	c.(493-495)gaG>gaT	p.E165D	KCNA6_ENST00000280684.3_Missense_Mutation_p.E165D	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	165						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						TGCTCTTTGAGTACCCAGAGA	0.637000										HNSCC(72;0.22)			14	35					1.49906e-05	1.82952e-05	0.457914	1	0
CLCA4	22802	broad.mit.edu	37	1	87025627	87025627	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:87025627A>T	ENST00000370563.3	+	2	214	c.172A>T	c.(172-174)Aca>Tca	p.T58S	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	58						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TATGGTGACTACAGCTTCTAC	0.343000													42	105					0	0	0.847076	0	0
BZRAP1	9256	broad.mit.edu	37	17	56395678	56395678	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:56395678G>A	ENST00000355701.3	-	14	2705	c.1835C>T	c.(1834-1836)tCc>tTc	p.S612F	BZRAP1_ENST00000268893.6_Missense_Mutation_p.S552F|BZRAP1_ENST00000343736.4_Missense_Mutation_p.S612F	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	612						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTGTGGATGGACTCGGAGTG	0.607000													10	55					0	0	0.361761	0	0
C9orf156	51531	broad.mit.edu	37	9	100678466	100678466	+	Silent	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr9:100678466T>A	ENST00000375119.3	-	2	307	c.231A>T	c.(229-231)ctA>ctT	p.L77L	C9orf156_ENST00000478126.1_Intron	NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	77					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				AAAACTGTTCTAGGCCCATCA	0.408000													7	31					0	0	0.307466	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136878	40136878	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:40136878G>T	ENST00000278198.2	-	2	2928	c.965C>A	c.(964-966)tCg>tAg	p.S322*	LRRC4C_ENST00000530763.1_Nonsense_Mutation_p.S322*|LRRC4C_ENST00000527150.1_Nonsense_Mutation_p.S322*|LRRC4C_ENST00000528697.1_Nonsense_Mutation_p.S322*			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	322	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGCTGTGTTCGAGGGGGCCAT	0.498000													17	48					2.23348e-06	2.86306e-06	0.500413	1	0
S1PR1	1901	broad.mit.edu	37	1	101704645	101704645	+	Silent	SNP	G	G	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:101704645G>A	ENST00000305352.6	+	2	480	c.105G>A	c.(103-105)ctG>ctA	p.L35L	S1PR1_ENST00000475821.1_3'UTR	NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	35					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CGGGAAAGCTGAATATCAGCG	0.517000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	60					0	0	0.717897	0	0
ARHGDIB	397	broad.mit.edu	37	12	15095548	15095548	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:15095548A>G	ENST00000228945.4	-	6	658	c.514T>C	c.(514-516)Tac>Cac	p.Y172H	ARHGDIB_ENST00000539131.1_5'UTR|ARHGDIB_ENST00000541546.1_Missense_Mutation_p.Y172H|ARHGDIB_ENST00000541644.1_Missense_Mutation_p.Y172H	NM_001175.4	NP_001166.3	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	172					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	15						TTGTTGTGGTACGTGCCTCGC	0.537000													15	98					0	0	0.520397	0	0
GJA10	84694	broad.mit.edu	37	6	90605017	90605017	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:90605017C>A	ENST00000369352.1	+	1	830	c.830C>A	c.(829-831)cCt>cAt	p.P277H		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	277					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCTTCATTGCCTGAAAGAATC	0.438000													17	33					3.52763e-06	4.4621e-06	0.520397	1	0
HS3ST5	222537	broad.mit.edu	37	6	114379192	114379192	+	Silent	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:114379192G>C	ENST00000312719.5	-	5	1458	c.270C>G	c.(268-270)ctC>ctG	p.L90L	HS3ST5_ENST00000411826.1_Silent_p.L90L|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	90					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TGGCCTTGGGGAGCTGCTGGA	0.572000													17	59					0	0	0.500413	0	0
FLNA	2316	broad.mit.edu	37	X	153590841	153590841	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:153590841T>C	ENST00000422373.1	-	17	2758	c.2510A>G	c.(2509-2511)aAg>aGg	p.K837R	FLNA_ENST00000369850.3_Missense_Mutation_p.K837R|FLNA_ENST00000344736.4_Missense_Mutation_p.K837R|FLNA_ENST00000360319.4_Missense_Mutation_p.K837R	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	837					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCGTGTACTTGACCGTGAA	0.592000													35	122					0	0	0.779181	0	0
SORCS1	114815	broad.mit.edu	37	10	108924037	108924037	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr10:108924037C>T	ENST00000263054.6	-	1	255	c.248G>A	c.(247-249)gGg>gAg	p.G83E	SORCS1_ENST00000344440.6_Missense_Mutation_p.G83E	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	83						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CGCTCGGTCCCCGGGGGCCAC	0.726000													12	14					0	0	0.387290	0	0
GJA10	84694	broad.mit.edu	37	6	90605016	90605016	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:90605016C>A	ENST00000369352.1	+	1	829	c.829C>A	c.(829-831)Cct>Act	p.P277T		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	277					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CTCTTCATTGCCTGAAAGAAT	0.438000													17	33					3.52763e-06	4.4621e-06	0.520397	1	0
MRPL24	79590	broad.mit.edu	37	1	156708225	156708225	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:156708225C>A	ENST00000368211.4	-	3	327	c.189G>T	c.(187-189)gaG>gaT	p.E63D	MRPL24_ENST00000361531.2_Missense_Mutation_p.E63D	NM_024540.3|NM_145729.2	NP_078816.2|NP_663781.1	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	63	KOW.				translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTCTAGGATCTCCACCTGTG	0.572000													38	167					6.90743e-12	1.11335e-11	0.788014	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106849374	106849374	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:106849374C>T	ENST00000526355.1	-	3	926	c.458G>A	c.(457-459)gGa>gAa	p.G153E	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.G153E|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.G153E	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	153					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CTGAAGAATTCCTGAGACATC	0.363000													7	21					0	0	0.248553	0	0
LAMB2	3913	broad.mit.edu	37	3	49166129	49166129	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr3:49166129T>C	ENST00000418109.1	-	15	2019	c.1855A>G	c.(1855-1857)Atg>Gtg	p.M619V	LAMB2_ENST00000305544.4_Missense_Mutation_p.M619V	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	619	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCATAGTCCATAGCCTTCGGC	0.597000													33	45					0	0	0.740014	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904758	144904758	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:144904758G>T	ENST00000370490.1	+	1	5070	c.815G>T	c.(814-816)aGt>aTt	p.S272I	SLITRK2_ENST00000434188.2_Missense_Mutation_p.S272I|SLITRK2_ENST00000428560.2_Missense_Mutation_p.S272I|SLITRK2_ENST00000413937.2_Missense_Mutation_p.S272I|SLITRK2_ENST00000447897.2_Missense_Mutation_p.S272I			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	272						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					AGTGATTCCAGTCAGAGGGGC	0.572000													50	104					6.31075e-24	1.19936e-23	0.870114	1	0
CDCA2	157313	broad.mit.edu	37	8	25325745	25325745	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr8:25325745G>T	ENST00000330560.3	+	6	1028	c.551G>T	c.(550-552)gGt>gTt	p.G184V	CDCA2_ENST00000380665.3_Missense_Mutation_p.G169V	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	184					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGAAAGGAAGGTCTCAGCGCT	0.363000													6	21					3.59834e-05	4.28213e-05	0.217242	1	0
HRH3	11255	broad.mit.edu	37	20	60791826	60791826	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr20:60791826A>T	ENST00000340177.5	-	3	858	c.574T>A	c.(574-576)Ttc>Atc	p.F192I	HRH3_ENST00000317393.6_Missense_Mutation_p.F192I	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	192					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TTGTAGAAGAACTCGGCATAG	0.577000													12	37					0	0	0.387290	0	0
DAAM1	23002	broad.mit.edu	37	14	59789744	59789744	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr14:59789744C>G	ENST00000395125.1	+	5	598	c.575C>G	c.(574-576)tCt>tGt	p.S192C	DAAM1_ENST00000351081.1_Missense_Mutation_p.S192C|DAAM1_ENST00000360909.3_Missense_Mutation_p.S192C	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	192	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ATGAACAACTCTCAAGGCCGG	0.448000													14	56					0	0	0.435327	0	0
CABIN1	23523	broad.mit.edu	37	22	24483437	24483437	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:24483437G>C	ENST00000398319.2	+	23	3681	c.3296G>C	c.(3295-3297)cGg>cCg	p.R1099P	CABIN1_ENST00000263119.5_Missense_Mutation_p.R1099P|CABIN1_ENST00000405822.2_Missense_Mutation_p.R1049P	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1099					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GCTCTGGCCCGGGCCAGCCGC	0.537000													9	40					0	0	0.335167	0	0
TRIML1	339976	broad.mit.edu	37	4	189060824	189060824	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr4:189060824G>T	ENST00000332517.3	+	1	252	c.112G>T	c.(112-114)Gtg>Ttg	p.V38L		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	38					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTTTTGTCTGGTGTGTCTCCT	0.527000													57	163					3.21867e-24	6.17856e-24	0.870114	1	0
ZNF318	24149	broad.mit.edu	37	6	43323347	43323347	+	Silent	SNP	T	T	A			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:43323347T>A	ENST00000361428.2	-	4	1802	c.1725A>T	c.(1723-1725)ccA>ccT	p.P575P	ZNF318_ENST00000318149.3_Silent_p.P575P	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	575					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCTTTACAGCTGGAGCTGAAG	0.468000													38	124					0	0	0.796494	0	0
FLG2	388698	broad.mit.edu	37	1	152327770	152327770	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:152327770G>T	ENST00000388718.5	-	3	2564	c.2492C>A	c.(2491-2493)tCt>tAt	p.S831Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	831	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAAAGCCAGAGGATTGTCC	0.517000													135	339					1.87168e-64	3.74336e-64	0.870114	1	0
OLIG3	167826	broad.mit.edu	37	6	137815151	137815151	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr6:137815151C>T	ENST00000367734.2	-	1	380	c.157G>A	c.(157-159)Ggg>Agg	p.G53R		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		AGGCTTTCCCCGGGCATCTTC	0.617000													19	118					0	0	0.557998	0	0
GPATCH4	54865	broad.mit.edu	37	1	156565503	156565504	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:156565503_156565504insT	ENST00000368232.4	-	8	746_747	c.614_615insA	c.(613-615)aaafs	p.K205fs	GPATCH4_ENST00000438976.2_Frame_Shift_Ins_p.K210fs|GPATCH4_ENST00000497287.1_5'UTR	NM_015590.3|NM_182679.2	NP_056405.2|NP_872620.1	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4	205						intracellular	nucleic acid binding			autonomic_ganglia(1)|breast(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(3)|stomach(1)	17	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTTTCTTTTTCTTTTTTTTGGG	0.535													7	133	---	---	---	---					
RGS21	431704	broad.mit.edu	37	1	192335245	192335245	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr1:192335245delT	ENST00000417209.2	+	5	624	c.450delT	c.(448-450)ccfs	p.P150fs		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	150					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						AATGGCTCCCTTTTTTGTGAG	0.338													9	19	---	---	---	---					
IL4	3565	broad.mit.edu	37	5	132015566	132015566	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr5:132015566delG	ENST00000231449.2	+	3	409	c.344delG	c.(343-345)tgfs	p.W115fs	IL4_ENST00000350025.2_Frame_Shift_Del_p.W99fs	NM_000589.3	NP_000580.1	P05112	IL4_HUMAN	interleukin 4	115					B cell differentiation|cellular defense response|chemotaxis|cholesterol metabolic process|connective tissue growth factor biosynthetic process|negative regulation of apoptosis|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of interleukin-13 production|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of MHC class II biosynthetic process|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|T-helper 2 cell cytokine production	extracellular space	cytokine activity|growth factor activity|interleukin-4 receptor binding			NS(1)|large_intestine(3)|lung(3)|prostate(1)	8		all_cancers(142;2.81e-05)|all_lung(232;1.47e-05)|Lung NSC(810;2.31e-05)|all_neural(839;0.0459)|Ovarian(839;0.0481)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.00245)		AGGAACCTCTGGGGCCTGGCG	0.602													8	45	---	---	---	---					
GS1-124K5.2	0	broad.mit.edu	37	7	65888987	65888988	+	RNA	INS	-	-	T	rs77289928		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:65888987_65888988insT	ENST00000442578.1	-	0	826																											Ctttttttttcttttttttttt	0.485													2	4	---	---	---	---					
STAG3L2	442582	broad.mit.edu	37	7	74300804	74300804	+	RNA	DEL	A	A	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr7:74300804delA	ENST00000423186.1	-	0	499							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CTTCATACTTAAAAAAAAAAA	0.458													4	6	---	---	---	---					
SLC22A20	440044	broad.mit.edu	37	11	65004445	65004445	+	RNA	DEL	G	G	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr11:65004445delG	ENST00000525437.1	+	0	1609							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						CCTGCGTATCGGAAATGTCCT	0.577													8	15	---	---	---	---					
OVCH1	341350	broad.mit.edu	37	12	29630297	29630297	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr12:29630297delG	ENST00000318184.5	-	11	1222	c.1223delC	c.(1222-1224)atfs	p.T408fs	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	408	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CTGTACAGCAGTAACGGTAAG	0.458													18	105	---	---	---	---					
CSPG4P5	114817	broad.mit.edu	37	15	84957480	84957499	+	RNA	DEL	GGCCCCACATCCATTGAGAA	GGCCCCACATCCATTGAGAA	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr15:84957480_84957499delGGCCCCACATCCATTGAGAA	ENST00000558801.1	-	0	7230_7249																											TGTGTGCACTGGCCCCACATCCATTGAGAAGGCCCCACAT	0.586													3	5	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	-	G	rs113730440		TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr17:26684394_26684395insG	ENST00000540200.1	-	1	78		c.e1+1		POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2							mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													4	6	---	---	---	---					
NOL4	8715	broad.mit.edu	37	18	31803106	31803106	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr18:31803106delG	ENST00000261592.5	-	1	409	c.112delC	c.(112-114)agfs	p.Q38fs	NOL4_ENST00000589544.1_Frame_Shift_Del_p.Q38fs|RP11-379L18.1_ENST00000587528.1_RNA|NOL4_ENST00000269185.4_5'UTR	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	38						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTGAGGAGCTGGACGATCCGT	0.577													26	105	---	---	---	---					
NCR1	9437	broad.mit.edu	37	19	55420680	55420680	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr19:55420680delC	ENST00000594765.1	+	4	457	c.432delC	c.(430-432)tgfs	p.C144fs	NCR1_ENST00000447255.1_Frame_Shift_Del_p.C144fs|NCR1_ENST00000357397.5_Frame_Shift_Del_p.C37fs|NCR1_ENST00000598576.1_Frame_Shift_Del_p.C132fs|NCR1_ENST00000350790.5_Frame_Shift_Del_p.C49fs|NCR1_ENST00000291890.4_Frame_Shift_Del_p.C144fs|NCR1_ENST00000338835.5_Frame_Shift_Del_p.C144fs			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	144	Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		CCTTCTACTGCCGTCTAGACA	0.562													9	47	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41648136	41648137	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr21:41648136_41648137insT	ENST00000400454.1	-	11	2720_2721	c.2243_2244insA	c.(2242-2244)aggfs	p.R748fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	748	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCAACGACCCATTGCTGAGAAC	0.525													20	49	---	---	---	---					
APOBEC3D	140564	broad.mit.edu	37	22	39421324	39421324	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chr22:39421324delG	ENST00000216099.7	+	3	867	c.460delG	c.(460-462)ggfs	p.G154fs	APOBEC3D_ENST00000381568.4_Frame_Shift_Del_p.G154fs|APOBEC3D_ENST00000427494.2_Intron	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	154					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					GCATAAGGCAGGGGCCCGTGT	0.597													11	53	---	---	---	---					
CDX4	1046	broad.mit.edu	37	X	72667267	72667267	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7546-01A-11D-2036-08	TCGA-97-7546-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0e867b98-7689-4cde-ac39-95561719484b	8ac57855-42a3-4a1c-bf03-c7733fe5cfe5	g.chrX:72667267delC	ENST00000373514.2	+	1	178	c.178delC	c.(178-180)ccfs	p.P60fs		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					TCCTCATATGCCCAGCATGGA	0.617													18	36	---	---	---	---					
