Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLP1	5354	broad.mit.edu	37	X	103041617	103041617	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:103041617T>A	ENST00000418604.1	+	4	695	c.415T>A	c.(415-417)Tgt>Agt	p.C139S	PLP1_ENST00000303958.2_Missense_Mutation_p.C139S|PLP1_ENST00000361621.2_Intron	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	139			Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GGAGCGGGTGTGTCATTGTTT	0.557000													58	139					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769025	247769025	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:247769025C>G	ENST00000320002.2	+	1	170	c.138C>G	c.(136-138)atC>atG	p.I46M	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCACCATAATCATCATCTCAT	0.463000													93	112					0	0	1	0	0
RASL12	51285	broad.mit.edu	37	15	65357604	65357604	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:65357604G>A	ENST00000220062.4	-	2	387	c.111C>T	c.(109-111)acC>acT	p.T37T	RASL12_ENST00000421977.3_Intron|RASL12_ENST00000434605.2_Silent_p.T26T	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	37					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						GAAACTTCACGGTCAGGGCTG	0.532000													3	15					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402257	248402257	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248402257C>A	ENST00000306687.1	+	1	27	c.27C>A	c.(25-27)aaC>aaA	p.N9K		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGACCTTCAACTCCATCTTCA	0.418000													29	66					4.31634e-10	5.85228e-10	1	1	0
HKR1	284459	broad.mit.edu	37	19	37854344	37854344	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:37854344G>A	ENST00000591471.1	+	9	2469	c.828G>A	c.(826-828)ggG>ggA	p.G276G	HKR1_ENST00000324411.4_Silent_p.G549G|HKR1_ENST00000589392.1_Silent_p.G531G|HKR1_ENST00000541583.2_Silent_p.G488G|HKR1_ENST00000544914.1_Silent_p.G276G|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000392153.3_Silent_p.G530G			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	549					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CACATTCAGGGGAAAAGCCTT	0.512000													8	33					0	0	1	0	0
RAB40C	57799	broad.mit.edu	37	16	640413	640413	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:640413C>T	ENST00000535977.1	+	2	344	c.122C>T	c.(121-123)tCc>tTc	p.S41F	RAB40C_ENST00000248139.3_Missense_Mutation_p.S41F|RAB40C_ENST00000539661.1_Missense_Mutation_p.S41F|RAB40C_ENST00000538492.1_Missense_Mutation_p.S41F	NM_001172663.1	NP_001166134.1	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	41					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	6		Hepatocellular(780;0.0218)				GCGGCAGAGTCCCCGTACGCC	0.716000													4	22					0	0	1	0	0
IGLV3-32	28787	broad.mit.edu	37	22	22937463	22937463	+	RNA	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr22:22937463G>T	ENST00000390303.2	+	0	320																											ACCATCACTGGGGCCCAGGCT	0.512000													14	32					5.01169e-05	5.71202e-05	1	1	0
ACTN2	88	broad.mit.edu	37	1	236911069	236911069	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:236911069C>A	ENST00000366578.4	+	13	1675	c.1509C>A	c.(1507-1509)gcC>gcA	p.A503A	ACTN2_ENST00000542672.1_Silent_p.A503A|ACTN2_ENST00000546208.1_5'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	503					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GGAGAGAAGCCCTAGAGGTGA	0.428000													3	21					0.004672	0.00489716	1	1	0
GPRASP1	9737	broad.mit.edu	37	X	101911737	101911737	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:101911737G>T	ENST00000537097.1	+	6	3709	c.2896G>T	c.(2896-2898)Ggg>Tgg	p.G966W	GPRASP1_ENST00000415986.1_Missense_Mutation_p.G966W|GPRASP1_ENST00000361600.5_Missense_Mutation_p.G966W|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000444152.1_Missense_Mutation_p.G966W	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	966	Glu-rich.|OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AAATGAGGAAGGGGCCATTGT	0.473000													15	56					5.3912e-06	6.33831e-06	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31323412	31323412	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:31323412G>C	ENST00000269197.5	+	12	3600	c.3600G>C	c.(3598-3600)gtG>gtC	p.V1200V		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1200	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ACTTATCTGTGCATAGTTCTG	0.418000													12	25					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741445	81741445	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:81741445G>T	ENST00000550584.2	-	17	2394	c.2099C>A	c.(2098-2100)cCa>cAa	p.P700Q	PPFIA2_ENST00000548586.1_Missense_Mutation_p.P700Q|PPFIA2_ENST00000549396.1_Missense_Mutation_p.P700Q|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000333447.7_Missense_Mutation_p.P682Q|PPFIA2_ENST00000407050.4_Missense_Mutation_p.P626Q|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000550359.2_Missense_Mutation_p.P547Q|PPFIA2_ENST00000541570.2_Missense_Mutation_p.P267Q|PPFIA2_ENST00000549325.1_Missense_Mutation_p.P682Q|PPFIA2_ENST00000552948.1_Missense_Mutation_p.P700Q|PPFIA2_ENST00000443686.3_Missense_Mutation_p.P601Q	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	626										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GGAGGTACCTGGGTGGACCCT	0.512000													30	104					8.16721e-17	1.33645e-16	1	1	0
ROR2	4920	broad.mit.edu	37	9	94486827	94486827	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:94486827C>A	ENST00000375708.3	-	9	2147	c.1949G>T	c.(1948-1950)gGg>gTg	p.G650V	ROR2_ENST00000375715.1_Missense_Mutation_p.G510V|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	650	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CAGCGAGTTCCCCAGCAGCTT	0.572000													16	33					1.02788e-11	1.466e-11	1	1	0
GPNMB	10457	broad.mit.edu	37	7	23300116	23300116	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:23300116C>A	ENST00000258733.4	+	6	1037	c.742C>A	c.(742-744)Cga>Aga	p.R248R	GPNMB_ENST00000381990.2_Silent_p.R248R|GPNMB_ENST00000539136.1_Silent_p.R149R|GPNMB_ENST00000453162.2_Silent_p.R190R			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	248	PKD.				negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GAAGAACGATCGAAATTCATC	0.383000													19	50					1.10513e-12	1.63422e-12	1	1	0
PRKD1	5587	broad.mit.edu	37	14	30047522	30047522	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:30047522G>A	ENST00000331968.5	-	17	2708	c.2479C>T	c.(2479-2481)Cgc>Tgc	p.R827C	PRKD1_ENST00000415220.2_Missense_Mutation_p.R835C	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	827	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		ACACTGTAGCGCTTTCTCATT	0.328000													5	9					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48882525	48882525	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:48882525T>G	ENST00000262105.2	+	10	1551	c.1342T>G	c.(1342-1344)Ttg>Gtg	p.L448V	MCM4_ENST00000518680.1_3'UTR|MCM4_ENST00000523944.1_Missense_Mutation_p.L448V	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	448					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ACGTGTGGAATTGCTTAAGGA	0.403000													14	51					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69077407	69077407	+	Silent	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:69077407T>A	ENST00000543976.1	-	12	2889	c.2643A>T	c.(2641-2643)gtA>gtT	p.V881V	CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|CTD-2013N24.2_ENST00000599467.1_RNA|CTD-2013N24.2_ENST00000597366.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|TMF1_ENST00000398559.2_Silent_p.V878V|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000601511.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	878					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		CAAGTGTTCTTACATATTCAT	0.353000													6	26					0	0	1	0	0
GPM6B	2824	broad.mit.edu	37	X	13825879	13825879	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:13825879C>G	ENST00000316715.4	-	2	508	c.71G>C	c.(70-72)aGa>aCa	p.R24T	GPM6B_ENST00000398361.3_Intron|GPM6B_ENST00000493677.1_5'UTR|GPM6B_ENST00000454189.2_Intron|GPM6B_ENST00000355135.2_Missense_Mutation_p.R24T|GPM6B_ENST00000356942.5_Intron	NM_001001995.1	NP_001001995.1	Q13491	GPM6B_HUMAN	glycoprotein M6B	20					cell differentiation|nervous system development	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|pancreas(1)	6						CATTTCAGCTCTGCTGTTCAC	0.473000													39	63					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19056725	19056725	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:19056725C>G	ENST00000421369.3	+	11	1746	c.1188C>G	c.(1186-1188)atC>atG	p.I396M	TMC7_ENST00000304381.5_Missense_Mutation_p.I506M|TMC7_ENST00000569532.1_Missense_Mutation_p.I506M	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	506						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TCATCATCATCTTGGCTGTGA	0.478000													9	58					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121615715	121615715	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:121615715C>A	ENST00000275159.6	-	11	1231		c.e11+1		TBC1D32_ENST00000398212.2_Splice_Site					TBC1 domain family, member 32																		ATAATACTTACTGCAATGCTT	0.294000													25	30					3.65163e-15	5.72417e-15	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176640158	176640158	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:176640158C>T	ENST00000367662.3	+	4	3208	c.2044C>T	c.(2044-2046)Cac>Tac	p.H682Y	PAPPA2_ENST00000367661.3_Missense_Mutation_p.H682Y	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	682	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GAACAGTACTCACTTCCTCAA	0.517000													14	185					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182591804	182591804	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:182591804G>T	ENST00000323116.5	+	19	2512		c.e19+1			NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B						aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTGCCAGAAGGTAAGAATATA	0.438000													6	13					0.00116845	0.00124985	1	1	0
CDH10	1008	broad.mit.edu	37	5	24491722	24491722	+	Silent	SNP	G	G	T	rs141786276		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:24491722G>T	ENST00000264463.4	-	11	2346	c.1839C>A	c.(1837-1839)gcC>gcA	p.A613A	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	613					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGGCGATCAAGGCCCCAGTGC	0.498000										HNSCC(23;0.051)			20	100					7.41877e-09	9.63333e-09	1	1	0
MVD	4597	broad.mit.edu	37	16	88723851	88723851	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:88723851G>A	ENST00000301012.3	-	4	425	c.396C>T	c.(394-396)gcC>gcT	p.A132A	MVD_ENST00000568709.1_5'UTR	NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	132					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CACCTAGGCAGGCATAGCCCG	0.692000													7	10					0	0	1	0	0
KRIT1	889	broad.mit.edu	37	7	91842527	91842527	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:91842527G>A	ENST00000394507.1	-	18	2790	c.2007C>T	c.(2005-2007)ctC>ctT	p.L669L	KRIT1_ENST00000412043.2_Silent_p.L669L|KRIT1_ENST00000394503.2_Silent_p.L621L|KRIT1_ENST00000340022.2_Silent_p.L669L|KRIT1_ENST00000394505.2_Silent_p.L669L	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	669	FERM.|Required for RAP1A binding.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCATGTTGAGGAGATGAAGTC	0.353000													13	34					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202392	248202392	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248202392G>A	ENST00000366479.2	+	1	919	c.823G>A	c.(823-825)Gtt>Att	p.V275I	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GATTCTGGCTGTTTTCTACAC	0.488000													20	77					0	0	1	0	0
PAAF1	80227	broad.mit.edu	37	11	73625495	73625495	+	Silent	SNP	C	C	G	rs150921516		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:73625495C>G	ENST00000544909.1	+	6	1025	c.768C>G	c.(766-768)ctC>ctG	p.L256L	PAAF1_ENST00000544552.1_Silent_p.L238L|PAAF1_ENST00000541951.1_Silent_p.L140L|PAAF1_ENST00000376384.5_Silent_p.L238L|PAAF1_ENST00000535604.1_Silent_p.L140L|PAAF1_ENST00000536003.1_Silent_p.L238L|PAAF1_ENST00000310571.3_Silent_p.L255L			Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	255					interspecies interaction between organisms	proteasome complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					AAATGCTGCTCTTGGCCCGGG	0.502000													6	53					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60184092	60184092	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:60184092C>A	ENST00000300187.6	+	5	1928	c.1651C>A	c.(1651-1653)Caa>Aaa	p.Q551K	MS4A14_ENST00000395005.2_Missense_Mutation_p.Q534K|MS4A14_ENST00000531783.1_Missense_Mutation_p.Q584K|MS4A14_ENST00000531787.1_Missense_Mutation_p.Q439K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	551	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						CGTAGATAAGCAAGCTCAACT	0.448000													10	25					0.000442599	0.000486393	1	1	0
ARHGEF39	84904	broad.mit.edu	37	9	35663038	35663038	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:35663038C>T	ENST00000378387.3	-	6	695	c.578G>A	c.(577-579)aGa>aAa	p.R193K	ARHGEF39_ENST00000378395.2_Missense_Mutation_p.R157K|ARHGEF39_ENST00000490970.1_Intron|ARHGEF39_ENST00000343259.3_Intron	NM_032818.2	NP_116207.2			Rho guanine nucleotide exchange factor (GEF) 39																		AGTATGGACTCTCTGGGCAGT	0.537000													9	51					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44280862	44280862	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:44280862G>A	ENST00000244571.4	-	1	201	c.199C>T	c.(199-201)Cgc>Tgc	p.R67C		NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	67					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	GGGTCGCCGCGGGGCCGCACG	0.632000											OREG0017474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	14					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73069290	73069290	+	RNA	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:73069290C>A	ENST00000429829.1	-	0	3298					NR_001564.2																						AAGAAAAGATCACTACTCAAA	0.383000													8	32					2.17888e-05	2.50523e-05	1	1	0
KCNK2	3776	broad.mit.edu	37	1	215259899	215259899	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:215259899G>A	ENST00000444842.2	+	2	385	c.235G>A	c.(235-237)Gtg>Atg	p.V79M	KCNK2_ENST00000391895.2_Missense_Mutation_p.V75M|KCNK2_ENST00000391894.2_Missense_Mutation_p.V64M	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	79							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CGGAGCCACCGTGTTCAAAGC	0.473000													4	77					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54758764	54758764	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:54758764G>C	ENST00000450632.1	-	6	1139	c.1062C>G	c.(1060-1062)ccC>ccG	p.P354P	LILRB5_ENST00000449561.2_Silent_p.P363P|LILRB5_ENST00000345866.6_Silent_p.P263P|LILRB5_ENST00000316219.5_Silent_p.P363P			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	363	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACACAGCGGGGGATGGGCTG	0.547000													10	72					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36623783	36623783	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:36623783C>T	ENST00000280527.2	+	2	725	c.358C>T	c.(358-360)Ctt>Ttt	p.L120F		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	120					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TGACCAACTGCTTGGTTTTAA	0.408000													25	48					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100548010	100548010	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:100548010G>C	ENST00000372907.3	-	1	35	c.24C>G	c.(22-24)ctC>ctG	p.L8L	TAF7L_ENST00000372905.2_5'UTR	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	8					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						AAGAAATGGGGAGCTGTCCCT	0.493000													76	235					0	0	1	0	0
C17orf66	256957	broad.mit.edu	37	17	34191520	34191520	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:34191520T>G	ENST00000311880.2	-	5	639	c.491A>C	c.(490-492)gAg>gCg	p.E164A	C17orf66_ENST00000592980.1_Missense_Mutation_p.E124A	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	164							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		ATAGAACTGCTCATCCTCTCT	0.473000													4	84					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42824524	42824524	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:42824524G>C	ENST00000598766.1	+	13	1201	c.1201G>C	c.(1201-1203)Gcc>Ccc	p.A401P	TMEM145_ENST00000301204.3_Missense_Mutation_p.A377P			Q8NBT3	TM145_HUMAN	transmembrane protein 145	377						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				CCCCAAGTGGGCCCGGGAGAA	0.577000													25	71					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172628584	172628584	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:172628584G>T	ENST00000367721.2	+	1	427	c.243G>T	c.(241-243)ctG>ctT	p.L81L	FASLG_ENST00000340030.3_Silent_p.L81L	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	81					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GCACAGGCCTGTGTCTCCTTG	0.602000													19	16					2.27525e-19	3.84363e-19	1	1	0
DEDD2	162989	broad.mit.edu	37	19	42719285	42719285	+	Splice_Site	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:42719285C>G	ENST00000595337.1	-	3	535	c.448_splice	c.e3+1	p.G150_splice	DEDD2_ENST00000598727.1_Splice_Site_p.G150_splice|DEDD2_ENST00000593804.1_5'UTR|DEDD2_ENST00000336034.4_Intron|DEDD2_ENST00000596251.1_Splice_Site_p.G150_splice	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	150					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				CTGGGCTCACCTGTCTCCCAC	0.542000													17	71					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169780333	169780333	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:169780333C>A	ENST00000263817.6	-	28	3890		c.e28-1			NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11						bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CCTGCACCGTCTGCAAAGAGA	0.488000													11	29					2.27111e-07	2.78946e-07	1	1	0
PCDH10	57575	broad.mit.edu	37	4	134072410	134072410	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:134072410C>A	ENST00000264360.4	+	1	1941	c.1115C>A	c.(1114-1116)gCg>gAg	p.A372E		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	372	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GAGGGCGCGGCGCCCGGCACT	0.622000													33	46					4.31634e-10	5.85228e-10	1	1	0
RBM24	221662	broad.mit.edu	37	6	17292285	17292285	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:17292285G>T	ENST00000379052.5	+	4	882	c.646G>T	c.(646-648)Gct>Tct	p.A216S	RBM24_ENST00000318204.5_Missense_Mutation_p.A171S|RBM24_ENST00000508508.1_3'UTR|RBM24_ENST00000425446.2_Missense_Mutation_p.A158S	NM_001143942.1	NP_001137414.1	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24	216	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	13	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			cgctgcagcagctgctgccgc	0.582000													14	32					1.52009e-12	2.23518e-12	1	1	0
MYH15	22989	broad.mit.edu	37	3	108179195	108179195	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:108179195C>T	ENST00000273353.3	-	18	2000	c.1944G>A	c.(1942-1944)aaG>aaA	p.K648K	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	648	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TCTTTCGTTTCTTCTCCCCAA	0.328000													6	10					0	0	1	0	0
TSC22D3	1831	broad.mit.edu	37	X	106959973	106959973	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:106959973G>T	ENST00000372397.2	-	1	392	c.69C>A	c.(67-69)tcC>tcA	p.S23S	TSC22D3_ENST00000514426.1_Intron|TSC22D3_ENST00000372384.2_Intron|TSC22D3_ENST00000372382.4_Intron|TSC22D3_ENST00000506081.1_Intron|TSC22D3_ENST00000372383.4_Intron|TSC22D3_ENST00000315660.4_Intron	NM_004089.3	NP_004080.2	Q99576	T22D3_HUMAN	TSC22 domain family, member 3	23	AP1-binding (By similarity).						sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)|lung(3)	6						AAGAGAAGAAGGAGATGGAGA	0.612000													35	72					2.05212e-20	3.50067e-20	1	1	0
CPS1	1373	broad.mit.edu	37	2	211481168	211481168	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:211481168C>A	ENST00000233072.5	+	21	2786	c.2590C>A	c.(2590-2592)Ctt>Att	p.L864I	CPS1_ENST00000430249.2_Missense_Mutation_p.L870I|CPS1_ENST00000451903.2_Missense_Mutation_p.L413I	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	864					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.L864I(2)|p.L870I(2)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAACATGTCCCTTGATGAGAT	0.363000													17	60					3.08376e-08	3.9166e-08	1	1	0
SYT5	6861	broad.mit.edu	37	19	55685998	55685998	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:55685998G>T	ENST00000354308.3	-	8	1216	c.847C>A	c.(847-849)Ctg>Atg	p.L283M	SYT5_ENST00000590851.1_Missense_Mutation_p.L279M|SYT5_ENST00000537500.1_Missense_Mutation_p.L283M|CTD-2587H24.5_ENST00000591665.1_RNA	NM_003180.2	NP_003171.2	O00445	SYT5_HUMAN	synaptotagmin V	283	C2 2.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity			kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCCTGCAGCAGGTGGACCTTG	0.522000													17	48					1.50039e-11	2.1225e-11	1	1	0
GP2	2813	broad.mit.edu	37	16	20327339	20327339	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:20327339G>C	ENST00000302555.5	-	9	1589	c.1440C>G	c.(1438-1440)cgC>cgG	p.R480R	GP2_ENST00000381360.5_Silent_p.R336R|GP2_ENST00000381362.4_Silent_p.R483R|GP2_ENST00000341642.5_Silent_p.R333R			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	483	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GTACTTCACTGCGGACTTGAC	0.483000													24	61					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587463	55587463	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:55587463G>A	ENST00000333976.4	+	1	378	c.358G>A	c.(358-360)Gcc>Acc	p.A120T		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				AGCTGTGATGGCCTATGACCG	0.453000													30	95					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113078567	113078567	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:113078567G>A	ENST00000316851.7	+	6	729	c.729G>A	c.(727-729)caG>caA	p.Q243Q	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.Q252Q|NCAM1_ENST00000533760.1_Silent_p.Q135Q	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	253	Ig-like C2-type 3.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ATGGGGAACAGATAGAGCAAG	0.423000													3	5					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663274	34663274	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:34663274A>G	ENST00000488417.1	+	2	889	c.769A>G	c.(769-771)Aag>Gag	p.K257E	C1orf94_ENST00000373374.3_Missense_Mutation_p.K67E	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	67							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				CCCTGACAACAAGAATGTGCT	0.557000													12	28					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64675542	64675542	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:64675542C>G	ENST00000357395.3	+	102	18567	c.7423C>G	c.(7423-7425)Cta>Gta	p.L2475V	SYNE2_ENST00000554584.1_Missense_Mutation_p.L6052V|SYNE2_ENST00000555022.1_5'UTR|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.L2475V|SYNE2_ENST00000358025.3_Missense_Mutation_p.L6090V|SYNE2_ENST00000555002.1_Missense_Mutation_p.L2724V|SYNE2_ENST00000344113.4_Missense_Mutation_p.L6090V			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6090					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGTGACGTCCTACTGCACGA	0.512000													31	52					0	0	1	0	0
RNF128	79589	broad.mit.edu	37	X	105970235	105970235	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:105970235C>G	ENST00000255499.2	+	1	342	c.92C>G	c.(91-93)cCg>cGg	p.P31R	RNF128_ENST00000324342.3_Intron	NM_194463.1	NP_919445.1	Q8TEB7	RN128_HUMAN	ring finger protein 128, E3 ubiquitin protein ligase	31						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)	11						GCCCTGAGTCCGCAGGCACCC	0.706000													3	17					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202407	248202407	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248202407C>A	ENST00000366479.2	+	1	934	c.838C>A	c.(838-840)Ctc>Atc	p.L280I	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTACACCATCCTCACCCCAAT	0.468000													22	81					1.22574e-08	1.57984e-08	1	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72468463	72468463	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:72468463G>T	ENST00000373208.1	+	4	799	c.799G>T	c.(799-801)Gtg>Ttg	p.V267L	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.V267L	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	267	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GCTGCTGGTGGTGGACGACTC	0.607000													23	85					3.28513e-13	4.95617e-13	1	1	0
STOX1	219736	broad.mit.edu	37	10	70646248	70646248	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:70646248A>T	ENST00000298596.6	+	3	2779	c.2696A>T	c.(2695-2697)cAa>cTa	p.Q899L	STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.Q789L|STOX1_ENST00000399169.4_Missense_Mutation_p.Q899L	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	899						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CATTTCCCACAAAAGTTCCAA	0.438000													14	39					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20494388	20494388	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:20494388G>A	ENST00000573854.1	+	13	1632	c.1518G>A	c.(1516-1518)aaG>aaA	p.K506K	ACSM2A_ENST00000396104.2_Silent_p.K506K|ACSM2A_ENST00000219054.6_Silent_p.K506K|ACSM2A_ENST00000536134.1_Silent_p.K278K|ACSM2A_ENST00000575690.1_Silent_p.K506K|ACSM2A_ENST00000417235.2_Silent_p.K427K	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	506					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGGTGGTGAAGGCATTTGTGG	0.498000													41	93					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103907013	103907013	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:103907013C>T	ENST00000278070.2	+	9	4303	c.4264C>T	c.(4264-4266)Cgc>Tgc	p.R1422C	PPRC1_ENST00000370012.1_Missense_Mutation_p.R389C|PPRC1_ENST00000489648.1_Intron|PPRC1_ENST00000413464.2_Intron	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1422	Arg-rich.|Necessary for interaction with CREB1 and NRF1.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CTGGCAGGGCCGCCGAGGCCG	0.617000													19	35					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114186070	114186070	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:114186070C>G	ENST00000297405.5	-	4	834	c.590G>C	c.(589-591)gGg>gCg	p.G197A	CSMD3_ENST00000352409.3_Missense_Mutation_p.G197A|CSMD3_ENST00000455883.2_Missense_Mutation_p.G197A|CSMD3_ENST00000343508.3_Missense_Mutation_p.G157A	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	197	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GATCTTGTCCCCGACGTCGAA	0.458000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	86					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85967511	85967511	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:85967511G>T	ENST00000263360.6	+	5	1195	c.509G>T	c.(508-510)gGc>gTc	p.G170V	EED_ENST00000351625.6_Missense_Mutation_p.G170V|EED_ENST00000327320.4_Missense_Mutation_p.G170V|EED_ENST00000528180.1_Missense_Mutation_p.G170V	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	170	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCTAGAGGCATAATTAGG	0.373000													10	25					4.84862e-15	7.53267e-15	1	1	0
COX5B	1329	broad.mit.edu	37	2	98263849	98263849	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:98263849A>G	ENST00000258424.2	+	3	267	c.220A>G	c.(220-222)Agg>Ggg	p.R74G	COX5B_ENST00000464949.1_3'UTR	NM_001862.2	NP_001853.2	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb	74					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3						TTCAGGCACCAGGGAAGACCC	0.393000													26	65					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95609655	95609655	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:95609655C>G	ENST00000395505.2	-	3	1398	c.1306G>C	c.(1306-1308)Gaa>Caa	p.E436Q	ZNF484_ENST00000375495.3_Missense_Mutation_p.E472Q|ZNF484_ENST00000332591.6_Missense_Mutation_p.E436Q|ZNF484_ENST00000395506.3_Missense_Mutation_p.E474Q|ANKRD19P_ENST00000473204.1_RNA	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TTCCCACATTCTGAACATATA	0.393000													6	31					0	0	1	0	0
EMP3	2014	broad.mit.edu	37	19	48830120	48830120	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:48830120G>T	ENST00000270221.6	+	2	320	c.19G>T	c.(19-21)Gtg>Ttg	p.V7L	EMP3_ENST00000597279.1_Missense_Mutation_p.V7L|EMP3_ENST00000596315.1_Intron	NM_001425.2	NP_001416.1	P54852	EMP3_HUMAN	epithelial membrane protein 3	7					cell growth|negative regulation of cell proliferation	integral to membrane				lung(1)	1		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		CCTCTTGCTGGTGGTCTCAGC	0.567000													53	155					8.81991e-31	1.59861e-30	1	1	0
DMD	1756	broad.mit.edu	37	X	32398778	32398778	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:32398778T>A	ENST00000357033.4	-	34	4900	c.4694A>T	c.(4693-4695)cAg>cTg	p.Q1565L	DMD_ENST00000378677.2_Missense_Mutation_p.Q1561L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1565	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTCTCCAACTGTTGCTTTCT	0.323000													24	50					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173481	126173481	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:126173481C>A	ENST00000339582.2	-	9	2763	c.1955G>T	c.(1954-1956)cGg>cTg	p.R652L	GRM8_ENST00000444921.2_Missense_Mutation_p.R652L|GRM8_ENST00000358373.3_Missense_Mutation_p.R652L|GRM8_ENST00000480995.1_5'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	652					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TAGGAAGACCCGTCGGAAGGA	0.448000										HNSCC(24;0.065)			16	41					2.48551e-13	3.76068e-13	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25446394	25446394	+	RNA	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:25446394A>G	ENST00000424208.1	+	0	1969				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CTGGTGCCCTAGTTTCCTGCA	0.582000													4	61					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186114890	186114890	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:186114890G>T	ENST00000271588.4	+	93	14672	c.14443G>T	c.(14443-14445)Gga>Tga	p.G4815*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.G4815*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4815	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CACAGTGGATGGAAGTTGGGG	0.478000													8	81					1.12685e-05	1.31298e-05	1	1	0
OCRL	4952	broad.mit.edu	37	X	128709136	128709136	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:128709136G>A	ENST00000371113.4	+	16	1787	c.1622G>A	c.(1621-1623)cGa>cAa	p.R541Q	OCRL_ENST00000357121.5_Missense_Mutation_p.R541Q	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	541					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						GTGGATGAACGAAGGTACCGG	0.408000													31	48					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42742644	42742644	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:42742644G>T	ENST00000379274.2	+	10	1208	c.779G>T	c.(778-780)tGg>tTg	p.W260L	DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Missense_Mutation_p.W151L|DGKH_ENST00000540693.1_Missense_Mutation_p.W396L|DGKH_ENST00000337343.4_Missense_Mutation_p.W396L|DGKH_ENST00000261491.4_Missense_Mutation_p.W396L|DGKH_ENST00000536612.1_Missense_Mutation_p.W260L			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	396					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AGTGTAGGTTGGGTTTTGTCA	0.333000													7	16					0.00010058	0.000112667	1	1	0
SLC19A1	6573	broad.mit.edu	37	21	46951949	46951949	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:46951949G>T	ENST00000311124.4	-	3	455	c.303C>A	c.(301-303)ctC>ctA	p.L101L	SLC19A1_ENST00000567670.1_Silent_p.L101L|SLC19A1_ENST00000485649.2_Silent_p.L61L|SLC19A1_ENST00000380010.4_Silent_p.L101L	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	101					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		ACACGAAGCTGAGCCCCTGCA	0.662000													6	41					0.00116845	0.00124985	1	1	0
RPS3	6188	broad.mit.edu	37	11	75115797	75115797	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:75115797A>G	ENST00000531188.1	+	6	682	c.620A>G	c.(619-621)cAc>cGc	p.H207R	RPS3_ENST00000278572.6_Missense_Mutation_p.H223R|RPS3_ENST00000524851.1_Missense_Mutation_p.H207R|RPS3_ENST00000526608.1_Missense_Mutation_p.H195R|RPS3_ENST00000534440.1_Missense_Mutation_p.H122R|RPS3_ENST00000527446.1_Missense_Mutation_p.H207R	NM_001005.4|NM_001260506.1|NM_001260507.1	NP_000996.2|NP_001247435.1|NP_001247436.1	P23396	RS3_HUMAN	ribosomal protein S3	207					activation of caspase activity|endocrine pancreas development|induction of apoptosis|negative regulation of DNA repair|negative regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus|ruffle membrane	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|iron-sulfur cluster binding|mRNA binding|NF-kappaB binding|protein kinase binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6						CTGCCTGACCACGTGAGCATT	0.582000													31	42					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155408305	155408305	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:155408305C>A	ENST00000368346.3	-	5	6280	c.5641G>T	c.(5641-5643)Gag>Tag	p.E1881*	ASH1L_ENST00000392403.3_Nonsense_Mutation_p.E1881*			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1881					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCTCCTTCCTCGTCTCTGTTC	0.488000													41	40					8.69298e-16	1.38769e-15	1	1	0
HKR1	284459	broad.mit.edu	37	19	37854120	37854120	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:37854120G>T	ENST00000591471.1	+	9	2245	c.604G>T	c.(604-606)Ggg>Tgg	p.G202W	HKR1_ENST00000324411.4_Missense_Mutation_p.G475W|HKR1_ENST00000589392.1_Missense_Mutation_p.G457W|HKR1_ENST00000541583.2_Missense_Mutation_p.G414W|HKR1_ENST00000544914.1_Missense_Mutation_p.G202W|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000392153.3_Missense_Mutation_p.G456W			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	475					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTGGAGTGCGGGCAGTGCTT	0.507000													23	62					3.6726e-16	5.93529e-16	1	1	0
TSNARE1	203062	broad.mit.edu	37	8	143395770	143395770	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:143395770G>A	ENST00000519651.1	-	7	549	c.446C>T	c.(445-447)cCc>cTc	p.P149L	TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000520166.1_Missense_Mutation_p.P368L|TSNARE1_ENST00000524325.1_Missense_Mutation_p.P368L|TSNARE1_ENST00000307180.3_Missense_Mutation_p.P369L			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	369					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CTGCGCCATGGGAAGCAGCGC	0.522000													8	23					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28648025	28648025	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:28648025C>A	ENST00000280904.6	-	16	3105	c.2662G>T	c.(2662-2664)Gag>Tag	p.E888*	DSC2_ENST00000251081.6_3'UTR	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	888					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AATTTGGGCTCCAAATTATCC	0.398000													13	38					1.3612e-06	1.63721e-06	1	1	0
SSBP3	23648	broad.mit.edu	37	1	54708962	54708962	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:54708962C>G	ENST00000371320.3	-	10	1072	c.662G>C	c.(661-663)aGc>aCc	p.S221T	SSBP3_ENST00000357475.4_Missense_Mutation_p.S201T|SSBP3_ENST00000417664.2_Missense_Mutation_p.S111T|SSBP3_ENST00000371319.3_Missense_Mutation_p.S194T|SSBP3_ENST00000326956.7_5'UTR	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	221	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						TCTCATGCCGCTGCCGTAATT	0.552000													97	207					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922523	37922523	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:37922523C>G	ENST00000346872.3	-	8	1111	c.1050G>C	c.(1048-1050)gaG>gaC	p.E350D	IKZF3_ENST00000535189.1_Missense_Mutation_p.E316D|IKZF3_ENST00000351680.3_Missense_Mutation_p.E311D|IKZF3_ENST00000350532.3_Missense_Mutation_p.E311D|IKZF3_ENST00000377958.2_Missense_Mutation_p.E263D|IKZF3_ENST00000583368.1_Missense_Mutation_p.E103D|IKZF3_ENST00000377944.3_Missense_Mutation_p.E207D|IKZF3_ENST00000467757.1_Missense_Mutation_p.E294D|IKZF3_ENST00000346243.3_Missense_Mutation_p.E272D|IKZF3_ENST00000439016.2_Missense_Mutation_p.E255D|IKZF3_ENST00000439167.2_Missense_Mutation_p.E277D|IKZF3_ENST00000394189.2_Missense_Mutation_p.E168D|IKZF3_ENST00000377952.2_Missense_Mutation_p.E129D|IKZF3_ENST00000377945.3_Missense_Mutation_p.E216D	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	350					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CGTTTGACATCTCAGCCCGGG	0.582000													6	47					0	0	1	0	0
SAA2	6289	broad.mit.edu	37	11	18269517	18269517	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:18269517C>G	ENST00000414546.2	-	2	86	c.42G>C	c.(40-42)ctG>ctC	p.L14L	SAA2_ENST00000526900.1_Silent_p.L14L|SAA2_ENST00000256733.4_Silent_p.L14L|SAA2_ENST00000529528.1_Silent_p.L14L|SAA2_ENST00000528349.1_Silent_p.L14L|SAA2-SAA4_ENST00000524555.1_RNA|SAA2_ENST00000530400.1_Silent_p.L14L	NM_001127380.2	NP_001120852.1			serum amyloid A2											central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(1)	6						TGCTGACACTCAGGACCAAGG	0.517000													4	61					0	0	1	0	0
YWHAZ	7534	broad.mit.edu	37	8	101936182	101936182	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:101936182C>A	ENST00000395957.2	-	6	1020		c.e6+1		YWHAZ_ENST00000457309.1_Splice_Site|YWHAZ_ENST00000353245.3_Splice_Site|YWHAZ_ENST00000521309.1_Splice_Site|YWHAZ_ENST00000395958.2_Splice_Site|YWHAZ_ENST00000419477.2_Splice_Site|YWHAZ_ENST00000395948.2_Splice_Site|YWHAZ_ENST00000395951.3_Splice_Site|YWHAZ_ENST00000395953.2_Splice_Site|YWHAZ_ENST00000395956.3_Splice_Site|YWHAZ_ENST00000522819.1_Splice_Site|YWHAZ_ENST00000522542.1_Splice_Site			P63104	1433Z_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide						anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding			large_intestine(1)|lung(2)	3	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	TATGTACTTACTGTCAAGTTG	0.313000													42	54					2.69774e-35	5.01147e-35	1	1	0
TOPORS	10210	broad.mit.edu	37	9	32541401	32541401	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:32541401T>C	ENST00000360538.2	-	3	3238	c.3122A>G	c.(3121-3123)gAc>gGc	p.D1041G	TOPORS_ENST00000379858.1_Missense_Mutation_p.D976G	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	1041					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CATATCACAGTCTCTACCAAG	0.383000													10	29					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53878094	53878094	+	Missense_Mutation	SNP	C	C	G	rs76762929	by1000genomes	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:53878094C>G	ENST00000471389.1	+	4	1001	c.779C>G	c.(778-780)tCt>tGt	p.S260C	FTO_ENST00000394647.3_5'UTR	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	260	Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.S260F(1)		endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GAGGATGACTCTCATCTCGAA	0.408000													4	36					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34038882	34038882	+	Splice_Site	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:34038882T>G	ENST00000382499.2	-	16	1929	c.1928_splice	c.e16-1	p.T644_splice	SYNJ1_ENST00000433931.2_Splice_Site_p.T644_splice|SYNJ1_ENST00000382491.3_Splice_Site_p.T600_splice|SYNJ1_ENST00000357345.3_Splice_Site_p.T605_splice|SYNJ1_ENST00000322229.7_Splice_Site_p.T605_splice	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	605	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TGATTTGTTGTGCTACAAGAA	0.358000													13	36					0	0	1	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159555	242159555	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:242159555G>T	ENST00000357246.3	-	4	418	c.354C>A	c.(352-354)acC>acA	p.T118T		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	118					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGGAGGCGTAGGTCATGTACA	0.557000													17	90					1.74485e-21	3.02595e-21	1	1	0
KCNK2	3776	broad.mit.edu	37	1	215345448	215345448	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:215345448G>T	ENST00000444842.2	+	5	895	c.745G>T	c.(745-747)Gaa>Taa	p.E249*	KCNK2_ENST00000391895.2_Nonsense_Mutation_p.E245*|KCNK2_ENST00000391894.2_Nonsense_Mutation_p.E234*	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	249							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CAAACACATAGAAGGCTGGAG	0.418000													24	81					1.33986e-20	2.30069e-20	1	1	0
GPRASP1	9737	broad.mit.edu	37	X	101911813	101911813	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:101911813C>G	ENST00000537097.1	+	6	3785	c.2972C>G	c.(2971-2973)tCc>tGc	p.S991C	GPRASP1_ENST00000415986.1_Missense_Mutation_p.S991C|GPRASP1_ENST00000361600.5_Missense_Mutation_p.S991C|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000444152.1_Missense_Mutation_p.S991C	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	991	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AACTGTGGGTCCAGGACATTA	0.517000													13	73					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128901599	128901599	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:128901599C>A	ENST00000371106.3	+	20	1953	c.1761C>A	c.(1759-1761)acC>acA	p.T587T		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	587					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GCTACCTGACCTTTGAAGTGG	0.572000													34	88					8.69298e-16	1.38769e-15	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140481843	140481843	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140481843G>T	ENST00000231130.2	+	1	1610	c.1610G>T	c.(1609-1611)gGc>gTc	p.G537V		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		537	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGACCGTGGCTCCCCGGCT	0.677000													29	51					2.61193e-14	4.02191e-14	1	1	0
GPR98	84059	broad.mit.edu	37	5	89979496	89979496	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:89979496A>G	ENST00000405460.2	+	28	5854	c.5758A>G	c.(5758-5760)Atc>Gtc	p.I1920V		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1920	Calx-beta 13.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCTGGCAACATCACATTTGA	0.468000													9	25					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21788231	21788231	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:21788231G>C	ENST00000328843.6	+	53	8596	c.8565G>C	c.(8563-8565)caG>caC	p.Q2855H	DNAH11_ENST00000409508.3_Missense_Mutation_p.Q2848H			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2855	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GAACCCCTCAGGGCTGTGCTC	0.542000									Kartagener syndrome				4	19					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51351120	51351120	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:51351120C>T	ENST00000522124.1	+	5	841	c.180C>T	c.(178-180)atC>atT	p.I60I	SNTG1_ENST00000276467.5_Silent_p.I60I|SNTG1_ENST00000518864.1_Silent_p.I60I|SNTG1_ENST00000517473.1_Silent_p.I60I	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	60	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CGGTGACCATCAGAAGACAAA	0.378000													8	13					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185815174	185815174	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:185815174A>T	ENST00000271588.4	+	2	514	c.285A>T	c.(283-285)acA>acT	p.T95T	HMCN1_ENST00000367492.2_Silent_p.T95T	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	95	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GCCCAGTGACAATTACCACAG	0.363000													7	40					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77325218	77325218	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:77325218G>T	ENST00000282849.5	-	21	3765	c.3347C>A	c.(3346-3348)cCa>cAa	p.P1116Q		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1116	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGGATGGGCTGGGCAAGCCCG	0.512000													30	75					8.88839e-20	1.50641e-19	1	1	0
CXorf21	80231	broad.mit.edu	37	X	30578036	30578036	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:30578036G>T	ENST00000378962.3	-	3	759	c.437C>A	c.(436-438)tCt>tAt	p.S146Y		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	146										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						ACTGCTCTCAGAGGGAAAATC	0.423000													12	29					1.49906e-05	1.73505e-05	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176708897	176708897	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:176708897G>T	ENST00000367662.3	+	13	5098	c.3934_splice	c.e13+1	p.G1312_splice		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1312					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCACTCTCTTGGTGAGTCTGA	0.483000													9	32					2.27111e-07	2.78946e-07	1	1	0
ESRRB	2103	broad.mit.edu	37	14	76906004	76906004	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:76906004G>T	ENST00000380887.2	+	2	380	c.308G>T	c.(307-309)tGc>tTc	p.C103F	ESRRB_ENST00000509242.1_Missense_Mutation_p.C103F|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Missense_Mutation_p.C103F|ESRRB_ENST00000261532.7_Missense_Mutation_p.C103F			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	103						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		AAGCGCCTGTGCCTCGTGTGC	0.617000													7	23					2.7689e-08	3.55126e-08	1	1	0
ATP11C	286410	broad.mit.edu	37	X	138878530	138878530	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:138878530C>A	ENST00000370557.1	-	12	2135	c.1108G>T	c.(1108-1110)Ggc>Tgc	p.G370C	ATP11C_ENST00000359686.2_Missense_Mutation_p.G373C|ATP11C_ENST00000327569.3_Missense_Mutation_p.G373C|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370543.1_Missense_Mutation_p.G373C|ATP11C_ENST00000361648.2_Missense_Mutation_p.G373C			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	373					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					AAGAAGGAGCCCAAGAATTTC	0.378000													15	27					1.5739e-10	2.16204e-10	1	1	0
RP11-909M7.3	0	broad.mit.edu	37	14	101439019	101439019	+	RNA	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:101439019G>C	ENST00000554693.2	+	0	384				SNORD114-15_ENST00000364687.1_RNA																							GATCGATGATGACCACTGGTG	0.363000													28	86					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152285383	152285383	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:152285383G>C	ENST00000368799.1	-	3	2014	c.1979C>G	c.(1978-1980)cCc>cGc	p.P660R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	660	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.P660H(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCTGGGGTGTCTGGA	0.542000									Ichthyosis				77	318					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45396684	45396684	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:45396684G>A	ENST00000303230.4	-	4	1197	c.1140C>T	c.(1138-1140)atC>atT	p.I380I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	380						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGGCCCCGACGATCATGCTCA	0.517000													15	63					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14610230	14610230	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:14610230G>T	ENST00000544627.1	+	8	2502		c.e8+1		ATF7IP_ENST00000541654.1_Intron|ATF7IP_ENST00000536444.1_Splice_Site|ATF7IP_ENST00000540793.1_Splice_Site|ATF7IP_ENST00000543189.1_Splice_Site|ATF7IP_ENST00000261168.4_Splice_Site			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein						DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GTGAATACAGGTAACTTTTTT	0.348000													3	13					0.004672	0.00489716	1	1	0
PPL	5493	broad.mit.edu	37	16	4934286	4934286	+	Missense_Mutation	SNP	C	C	T	rs143676756	byFrequency	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:4934286C>T	ENST00000345988.2	-	22	4459	c.4370G>A	c.(4369-4371)cGa>cAa	p.R1457Q	PPL_ENST00000590782.2_Missense_Mutation_p.R1455Q	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1457					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GGCATGCTCTCGCGCCTGCTG	0.662000													11	103					0	0	1	0	0
TPM1	7168	broad.mit.edu	37	15	63353426	63353426	+	Missense_Mutation	SNP	G	G	A	rs1131001		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:63353426G>A	ENST00000358278.3	+	6	738	c.593G>A	c.(592-594)aGa>aAa	p.R198K	TPM1_ENST00000560959.1_Missense_Mutation_p.R162K|TPM1_ENST00000559281.1_Intron|TPM1_ENST00000560445.1_Intron|TPM1_ENST00000404484.4_Missense_Mutation_p.R162K|TPM1_ENST00000403994.3_Intron|TPM1_ENST00000317516.7_Missense_Mutation_p.R162K|TPM1_ENST00000357980.4_Intron|TPM1_ENST00000334895.5_Intron|TPM1_ENST00000559556.1_Intron|TPM1_ENST00000559397.1_Missense_Mutation_p.R198K|TPM1_ENST00000288398.6_Missense_Mutation_p.R198K|TPM1_ENST00000267996.7_Intron	NM_001018006.1	NP_001018006.1	P09493	TPM1_HUMAN	tropomyosin 1 (alpha)	198					cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle			endometrium(1)|large_intestine(1)|lung(2)	4						GAACAATTAAGAATAATGGAT	0.443000													6	36					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132455	49132455	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:49132455C>T	ENST00000443164.1	+	5	2281	c.1576C>T	c.(1576-1578)Ccg>Tcg	p.P526S	SPHK2_ENST00000599748.1_Missense_Mutation_p.P428S|SPHK2_ENST00000245222.4_Missense_Mutation_p.P464S|SPHK2_ENST00000600537.1_Missense_Mutation_p.P405S|SPHK2_ENST00000340932.3_Missense_Mutation_p.P426S|SPHK2_ENST00000598088.1_Missense_Mutation_p.P464S|SPHK2_ENST00000599029.1_Missense_Mutation_p.P428S			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	464					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TGGGGATGCTCCGCTGTCCCC	0.682000													41	116					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102291827	102291827	+	RNA	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:102291827G>T	ENST00000561463.1	+	0	593																											AAACCACCCAGAACCTGGTGG	0.537000													11	37					2.32078e-09	3.07475e-09	1	1	0
SKA3	221150	broad.mit.edu	37	13	21729278	21729278	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:21729278C>A	ENST00000400018.3	-	8	1200	c.1131G>T	c.(1129-1131)tgG>tgT	p.W377C	SKA3_ENST00000314759.5_3'UTR	NM_001166017.1	NP_001159489.1	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	0					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TTGGATAGATCCACTGGAATT	0.353000													3	13					0.004672	0.00489716	1	1	0
ZIC1	7545	broad.mit.edu	37	3	147128612	147128612	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:147128612C>A	ENST00000282928.4	+	1	1442	c.713C>A	c.(712-714)cCc>cAc	p.P238H		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	238					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P238H(1)		central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CTGGCCAACCCCAAAAAGTCG	0.592000													7	25					0.0293803	0.0300128	1	1	0
ACTN2	88	broad.mit.edu	37	1	236891015	236891015	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:236891015C>A	ENST00000366578.4	+	6	740	c.574C>A	c.(574-576)Cga>Aga	p.R192R	ACTN2_ENST00000542672.1_Silent_p.R192R|ACTN2_ENST00000492634.1_3'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	192	Actin-binding.|CH 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding	p.R192*(1)		endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCTCATCCACCGACACCGGCC	0.547000													17	91					5.3912e-06	6.33831e-06	1	1	0
ANO9	338440	broad.mit.edu	37	11	433355	433355	+	Missense_Mutation	SNP	G	G	T	rs145003945	byFrequency	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:433355G>T	ENST00000332826.6	-	4	393	c.309C>A	c.(307-309)caC>caA	p.H103Q		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	103						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						CCAGCTCGGCGTGGGGGGCAG	0.642000													23	37					7.4402e-23	1.30328e-22	1	1	0
ABCA4	24	broad.mit.edu	37	1	94574223	94574223	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:94574223C>T	ENST00000370225.3	-	4	438	c.352G>A	c.(352-354)Gag>Aag	p.E118K	ABCA4_ENST00000535735.1_Missense_Mutation_p.E118K	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	118					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TGCTGGCTCTCTGGTGCATTC	0.448000													14	42					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949358	27949358	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:27949358G>A	ENST00000379992.2	-	6	1761	c.1312C>T	c.(1312-1314)Ccg>Tcg	p.P438S	LINGO2_ENST00000308675.3_Missense_Mutation_p.P438S	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	438	Ig-like C2-type.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		ACAGGCTGCGGGTCTCCATCT	0.517000													14	40					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775126	72775126	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:72775126G>A	ENST00000299687.5	+	8	5449	c.5449G>A	c.(5449-5451)Gag>Aag	p.E1817K		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1817					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CAAGTCGTACGAGTGCCGTCT	0.557000													26	77					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30081430	30081430	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:30081430C>T	ENST00000569798.1	+	8	1256	c.1079C>T	c.(1078-1080)cCt>cTt	p.P360L	ALDOA_ENST00000563060.2_Intron|ALDOA_ENST00000566897.1_Intron|ALDOA_ENST00000338110.5_Intron|ALDOA_ENST00000564546.1_Intron|ALDOA_ENST00000395248.1_Intron|ALDOA_ENST00000395240.3_Intron|ALDOA_ENST00000412304.2_Intron|ALDOA_ENST00000569545.1_Intron|ALDOA_ENST00000564595.2_Intron			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	0					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						ACCCCTCTCCCTGCTTAGGCC	0.607000													21	53					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55087568	55087568	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:55087568T>A	ENST00000251377.3	+	7	1380	c.1247T>A	c.(1246-1248)gTg>gAg	p.V416E	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.V416E|LILRA2_ENST00000251376.3_Missense_Mutation_p.V416E|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.V404E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CTGGAGCTCGTGGTCTCAGGT	0.612000													24	84					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89390222	89390222	+	Splice_Site	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:89390222G>A	ENST00000336596.2	+	4	1195		c.e4+1		EPHA3_ENST00000452448.2_Splice_Site|EPHA3_ENST00000494014.1_Splice_Site	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3							extracellular region|integral to plasma membrane	ATP binding	p.?(2)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GCTTGTACCCGTGAGTAGTTT	0.443000										TSP Lung(6;0.00050)			21	83					0	0	1	0	0
KCTD15	79047	broad.mit.edu	37	19	34302445	34302445	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:34302445C>G	ENST00000284006.5	+	6	933	c.681C>G	c.(679-681)ctC>ctG	p.L227L	KCTD15_ENST00000430256.2_Silent_p.L227L|KCTD15_ENST00000589786.1_Silent_p.L227L|KCTD15_ENST00000588881.1_Silent_p.L227L	NM_001129994.1|NM_001129995.1|NM_024076.2	NP_001123466.1|NP_001123467.1|NP_076981.2	Q96SI1	KCD15_HUMAN	potassium channel tetramerization domain containing 15	227						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|lung(2)|pancreas(1)|urinary_tract(1)	5	Esophageal squamous(110;0.162)					ACTGCCGGCTCAACTCGGTAC	0.697000													9	43					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3822144	3822144	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:3822144T>C	ENST00000262961.4	-	9	1436	c.1426A>G	c.(1426-1428)Agt>Ggt	p.S476G		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	476						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCGTTGAAACTGCACTCGCAC	0.667000													7	9					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55594811	55594811	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:55594811G>T	ENST00000378397.1	+	1	117	c.117G>T	c.(115-117)ttG>ttT	p.L39F		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				GAGTCACGTTGTTAGCCAATC	0.507000										HNSCC(27;0.073)			12	237					4.93089e-13	7.37514e-13	1	1	0
UBE4B	10277	broad.mit.edu	37	1	10165755	10165755	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:10165755C>G	ENST00000377157.3	+	6	1475	c.414C>G	c.(412-414)agC>agG	p.S138R	UBE4B_ENST00000343090.6_Missense_Mutation_p.S254R|UBE4B_ENST00000253251.8_Missense_Mutation_p.S254R	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	380					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CAGGAACAAGCCCCATGTTCT	0.488000													9	40					0	0	1	0	0
MARCKS	4082	broad.mit.edu	37	6	114181669	114181669	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:114181669G>A	ENST00000368635.4	+	2	1294	c.913G>A	c.(913-915)Gca>Aca	p.A305T		NM_002356.5	NP_002347.5	P29966	MARCS_HUMAN	myristoylated alanine-rich protein kinase C substrate	305				PGAPPEQEAAPAEEPAAAAASS -> LVCPRRGGSPRGGAR GRRSLNQ (in Ref. 1; AAA59555).	energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding			breast(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		CGCGGCCGCCGCAGCCTCGTC	0.781000													3	21					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72211423	72211423	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:72211423A>T	ENST00000340726.3	-	9	1324	c.685T>A	c.(685-687)Tat>Aat	p.Y229N	EYA1_ENST00000388740.3_Missense_Mutation_p.Y196N|EYA1_ENST00000388743.2_Missense_Mutation_p.Y228N|EYA1_ENST00000419131.1_Missense_Mutation_p.Y224N|EYA1_ENST00000388742.4_Missense_Mutation_p.Y229N|EYA1_ENST00000303824.7_Missense_Mutation_p.Y223N|EYA1_ENST00000388741.2_Missense_Mutation_p.Y195N	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	229					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGTTATAATACTGTGCGTAC	0.468000													36	109					0	0	1	0	0
ALAS2	212	broad.mit.edu	37	X	55042168	55042168	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:55042168G>T	ENST00000330807.5	-	8	1148	c.1011C>A	c.(1009-1011)atC>atA	p.I337I	ALAS2_ENST00000498636.1_5'UTR|ALAS2_ENST00000396198.3_Silent_p.I324I|ALAS2_ENST00000335854.4_Silent_p.I300I	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	337					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	CGAGGGGACAGATGGCACCTG	0.552000													10	32					7.03913e-09	9.20908e-09	1	1	0
ZNF680	340252	broad.mit.edu	37	7	63982213	63982213	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:63982213C>A	ENST00000309683.6	-	4	1070	c.919G>T	c.(919-921)Gca>Tca	p.A307S		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				GTAAGGGTTGCAAACCAGTTA	0.343000													3	17					0.000602214	0.000657648	1	1	0
PAQR9	344838	broad.mit.edu	37	3	142681067	142681067	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:142681067G>T	ENST00000340634.3	-	1	1111	c.1112C>A	c.(1111-1113)tCc>tAc	p.S371Y		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	371						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						GCAGAATTCGGAGCTGTTTAG	0.532000													25	84					2.65835e-16	4.32292e-16	1	1	0
DDR1	780	broad.mit.edu	37	6	30866676	30866676	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:30866676G>T	ENST00000324771.8	+	19	3011	c.2463G>T	c.(2461-2463)acG>acT	p.T821T	DDR1_ENST00000376570.4_Silent_p.T784T|DDR1_ENST00000376575.3_Silent_p.T827T|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000376568.3_Silent_p.T821T|DDR1_ENST00000508312.1_Silent_p.T802T|DDR1_ENST00000376569.3_Silent_p.T784T|DDR1_ENST00000376567.2_Silent_p.T784T|DDR1_ENST00000452441.1_Silent_p.T821T|DDR1_ENST00000418800.2_Silent_p.T784T|DDR1_ENST00000513240.1_Silent_p.T827T|DDR1_ENST00000454612.2_Silent_p.T784T|DDR1_ENST00000446312.1_3'UTR			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	821	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	GGAAGTTCACGACTGCGAGTG	0.592000													79	121					9.54843e-35	1.76747e-34	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184777292	184777292	+	Silent	SNP	G	G	A	rs147120611	byFrequency	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:184777292G>A	ENST00000367511.3	-	10	1444	c.1251C>T	c.(1249-1251)caC>caT	p.H417H	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	417					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GCAGGCGCTCGTGAAGCAGGT	0.512000													4	114					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354112	57354112	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:57354112C>T	ENST00000314922.3	-	2	599	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G175S	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	175					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTATCACTGCCATCCTGGTGG	0.522000													71	71					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206872011	206872011	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:206872011C>G	ENST00000403263.1	-	10	2319	c.1915G>C	c.(1915-1917)Gaa>Caa	p.E639Q		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	639					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.E639K(1)|p.E534K(1)		NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						ACTATACCTTCAAAAAAATCA	0.348000													9	20					0	0	1	0	0
UBQLN2	29978	broad.mit.edu	37	X	56591627	56591627	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:56591627G>T	ENST00000338222.5	+	1	1602	c.1321G>T	c.(1321-1323)Gac>Tac	p.D441Y		NM_013444.3	NP_038472.2	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	441						cytoplasm|nucleus|plasma membrane	binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)	21						GCAGAATCCAGACACACTATC	0.532000													13	40					2.32078e-09	3.07475e-09	1	1	0
C1orf94	84970	broad.mit.edu	37	1	34663011	34663011	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:34663011G>T	ENST00000488417.1	+	2	626	c.506G>T	c.(505-507)gGc>gTc	p.G169V	C1orf94_ENST00000373374.3_5'UTR	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	372							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				CTAGTGGCAGGCAGTAATGAG	0.597000													6	16					0.00116845	0.00124985	1	1	0
BCL11B	64919	broad.mit.edu	37	14	99642443	99642443	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:99642443G>T	ENST00000345514.2	-	3	783	c.517C>A	c.(517-519)Cac>Aac	p.H173N	BCL11B_ENST00000357195.3_Missense_Mutation_p.H244N|BCL11B_ENST00000443726.2_Missense_Mutation_p.H50N	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	244						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CGGAAGCCGTGCGTGTTCTGC	0.662000			T	TLX3	T-ALL								5	23					3.59834e-05	4.1282e-05	1	1	0
FAM83B	222584	broad.mit.edu	37	6	54805297	54805297	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:54805297G>C	ENST00000306858.7	+	5	1644	c.1528G>C	c.(1528-1530)Gac>Cac	p.D510H		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	510										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AGCTACACCGGACTCAAATGG	0.423000													16	66					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2209923	2209923	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:2209923T>C	ENST00000511885.2	-	5	858	c.505A>G	c.(505-507)Agt>Ggt	p.S169G	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Missense_Mutation_p.S169G			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	169					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			ATTTGTTTACTTGTTTTCTCT	0.303000								DNA polymerases (catalytic subunits)					4	15					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160690611	160690611	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:160690611T>C	ENST00000263636.4	-	27	3812	c.3785A>G	c.(3784-3786)aAg>aGg	p.K1262R	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.K1262R|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.K1262R|LY75_ENST00000554112.1_Missense_Mutation_p.K1262R|LY75_ENST00000553424.1_Missense_Mutation_p.K1262R	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		ATGCCTATTCTTTGTTATTAT	0.353000													14	32					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791330	60791330	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:60791330G>T	ENST00000340177.5	-	3	1354	c.1070C>A	c.(1069-1071)gCc>gAc	p.A357D	HRH3_ENST00000317393.6_Missense_Mutation_p.A357D	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	357					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CAGCGACTTGGCCACTTTCCT	0.637000													10	17					3.07112e-06	3.64346e-06	1	1	0
IQSEC1	9922	broad.mit.edu	37	3	12950774	12950774	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:12950774C>A	ENST00000273221.4	-	11	2835	c.2620_splice	c.e11+1	p.E873_splice		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	873					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGTACTCACACTCTATCCTGT	0.547000													25	90					1.77063e-15	2.79236e-15	1	1	0
POMT2	29954	broad.mit.edu	37	14	77772688	77772688	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:77772688T>A	ENST00000261534.4	-	3	632	c.430A>T	c.(430-432)Atg>Ttg	p.M144L	POMT2_ENST00000556880.1_5'UTR	NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	144					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		ACTCCTCTCATTCCCATGTAG	0.488000													8	30					0	0	1	0	0
HIST2H2BB	338391	broad.mit.edu	37	1	149375134	149375134	+	RNA	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:149375134C>A	ENST00000415338.1	-	0	1061																											AGTTTTTCCACTGGAATTCTA	0.448000													21	183					7.92952e-12	1.13403e-11	1	1	0
NLRP12	91662	broad.mit.edu	37	19	54310817	54310817	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:54310817C>A	ENST00000324134.6	-	4	2343	c.2175G>T	c.(2173-2175)ctG>ctT	p.L725L	NLRP12_ENST00000391773.1_Silent_p.L726L|NLRP12_ENST00000391775.3_Silent_p.L725L|NLRP12_ENST00000354278.3_Silent_p.L725L|NLRP12_ENST00000351894.4_Silent_p.L725L|NLRP12_ENST00000345770.5_Silent_p.L726L|NLRP12_ENST00000535162.1_Silent_p.L725L|NLRP12_ENST00000391772.1_Silent_p.L726L	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	725					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCGGCTGCCCAGGGCATTTC	0.582000													17	49					4.14922e-12	6.03312e-12	1	1	0
SCTR	6344	broad.mit.edu	37	2	120209622	120209622	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:120209622C>A	ENST00000019103.5	-	9	1152	c.885G>T	c.(883-885)tgG>tgT	p.W295C		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	295					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	GAATGATCCACCAGATGGATG	0.587000													14	26					1.99824e-07	2.46591e-07	1	1	0
SH3TC2	79628	broad.mit.edu	37	5	148388422	148388422	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:148388422G>C	ENST00000538184.1	-	11	2999	c.2111C>G	c.(2110-2112)aCa>aGa	p.T704R	SH3TC2_ENST00000515425.1_Missense_Mutation_p.T1157R|SH3TC2_ENST00000512049.1_Missense_Mutation_p.T1150R			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1157							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGTGACTGTGCTGAGCCT	0.517000													32	93					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71007821	71007821	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:71007821C>A	ENST00000393567.2	-	34	5290	c.5140G>T	c.(5140-5142)Gga>Tga	p.G1714*		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1714										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGGCACTGTCCACACTGAATT	0.488000													29	87					1.06647e-15	1.68697e-15	1	1	0
DARC	2532	broad.mit.edu	37	1	159176075	159176075	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:159176075G>T	ENST00000537147.1	+	3	1689	c.846G>T	c.(844-846)ctG>ctT	p.L282L	DARC_ENST00000368122.2_Silent_p.L282L|DARC_ENST00000368121.2_Silent_p.L284L			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	282					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					AGCAGGCTCTGGACCTGCTGC	0.582000													119	128					4.38445e-86	8.26239e-86	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49447314	49447314	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:49447314C>A	ENST00000301067.7	-	6	783	c.784G>T	c.(784-786)Gcc>Tcc	p.A262S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.L260fs*8(1)									CGTTTGCGGGCAGTCAGAGCA	0.582000													5	8					0.000602214	0.000657648	1	1	0
MMP17	4326	broad.mit.edu	37	12	132325149	132325149	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:132325149G>T	ENST00000360564.1	+	4	556	c.454G>T	c.(454-456)Ggg>Tgg	p.G152W	MMP17_ENST00000535291.1_Missense_Mutation_p.G68W	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	152					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding	p.G152R(1)		endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CTCACCACTGGGGCACGACAC	0.667000													29	68					5.8336e-16	9.39858e-16	1	1	0
TRIM58	25893	broad.mit.edu	37	1	248039386	248039386	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248039386G>T	ENST00000366481.3	+	6	1104	c.1056G>T	c.(1054-1056)gtG>gtT	p.V352V	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	352	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGTTCTGGTGGGAGAAGGAG	0.577000													25	38					1.75199e-13	2.67408e-13	1	1	0
HGF	3082	broad.mit.edu	37	7	81388018	81388018	+	Silent	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:81388018A>G	ENST00000222390.5	-	3	583	c.357T>C	c.(355-357)taT>taC	p.Y119Y	HGF_ENST00000423064.2_Silent_p.Y119Y|HGF_ENST00000453018.1_Silent_p.Y16Y|HGF_ENST00000457544.2_Silent_p.Y119Y|HGF_ENST00000453411.1_Silent_p.Y119Y|HGF_ENST00000354224.6_Silent_p.Y119Y|HGF_ENST00000444829.2_Silent_p.Y119Y	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	119	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CTTTGTTTTCATAGAGGTCAA	0.343000													15	27					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6980545	6980545	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:6980545G>T	ENST00000389658.3	-	42	6075	c.5982C>A	c.(5980-5982)ctC>ctA	p.L1994L		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1994	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAAGTATCAAGAGTGATTCAT	0.348000													7	20					1.06961e-07	1.33255e-07	1	1	0
TNS3	64759	broad.mit.edu	37	7	47384421	47384421	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:47384421C>A	ENST00000398879.1	-	20	2948	c.2582G>T	c.(2581-2583)cGc>cTc	p.R861L	TNS3_ENST00000311160.9_Missense_Mutation_p.R861L|TNS3_ENST00000355730.3_Missense_Mutation_p.R621L			Q68CZ2	TENS3_HUMAN	tensin 3	861						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CGGAGGATGGCGCAGCGCTGT	0.582000													20	37					9.95505e-16	1.57949e-15	1	1	0
CMKLR1	1240	broad.mit.edu	37	12	108686252	108686252	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:108686252A>T	ENST00000312143.7	-	3	851	c.488T>A	c.(487-489)aTc>aAc	p.I163N	CMKLR1_ENST00000412676.1_Missense_Mutation_p.I163N|CMKLR1_ENST00000550402.1_Missense_Mutation_p.I163N|CMKLR1_ENST00000552995.1_Missense_Mutation_p.I161N|CMKLR1_ENST00000397688.2_Missense_Mutation_p.I161N	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	163					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						CAGGACCCAGATGACCATGCA	0.562000													21	62					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27097658	27097658	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:27097658G>T	ENST00000324856.7	+	12	3618	c.3247G>T	c.(3247-3249)Ggc>Tgc	p.G1083C	ARID1A_ENST00000374152.2_Missense_Mutation_p.G700C|ARID1A_ENST00000457599.2_Missense_Mutation_p.G1083C	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1083	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTCAATGTGGGCACATCAAG	0.483000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								13	24					4.7546e-09	6.25165e-09	1	1	0
MAPK3	5595	broad.mit.edu	37	16	30129737	30129737	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:30129737G>T	ENST00000484663.1	-	2	1267	c.134C>A	c.(133-135)tCc>tAc	p.S45Y	MAPK3_ENST00000263025.4_Missense_Mutation_p.S159Y|MAPK3_ENST00000403394.1_Missense_Mutation_p.S159Y|MAPK3_ENST00000395202.1_Missense_Mutation_p.S159Y|MAPK3_ENST00000395199.3_Missense_Mutation_p.S159Y|MAPK3_ENST00000395200.1_Missense_Mutation_p.S130Y|MAPK3_ENST00000322266.5_Missense_Mutation_p.S159Y			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	159	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CACGTTGGCGGAGTGGATGTA	0.562000													6	85					0.248553	0.251443	1	1	0
TMPRSS11D	9407	broad.mit.edu	37	4	68699078	68699078	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:68699078A>T	ENST00000283916.6	-	7	634	c.536T>A	c.(535-537)cTa>cAa	p.L179Q	TMPRSS11D_ENST00000509584.1_5'UTR|TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.L62Q|RP11-453E17.1_ENST00000500538.2_RNA	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	179					proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CAATGTTATTAGGTCTGGACC	0.488000													68	122					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14183682	14183682	+	RNA	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:14183682C>G	ENST00000581935.1	+	0	533																				lung(3)	3						TGCCAGTGGCCATGTGAAAGT	0.393000													7	162					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133119269	133119269	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:133119269C>G	ENST00000302334.2	+	1	431	c.342C>G	c.(340-342)tgC>tgG	p.C114W		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	114	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						TAGGGGGCTGCCTGGTGGAAT	0.612000													13	62					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590064	156590064	+	Missense_Mutation	SNP	G	G	C	rs150872087		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:156590064G>C	ENST00000302938.4	-	2	1307	c.1212C>G	c.(1210-1212)agC>agG	p.S404R		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	404						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTAGCCTTCGCTTTGCAAGG	0.507000													7	42					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119115904	119115904	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:119115904G>A	ENST00000328252.3	+	17	4548	c.4179G>A	c.(4177-4179)cgG>cgA	p.R1393R	PAPPA_ENST00000534838.1_Silent_p.R431R	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1393	Sushi 3.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CTTGAAGACGGGCCTTCAAGA	0.537000													24	56					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16874726	16874726	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:16874726C>A	ENST00000524140.2	+	9	2639	c.2221C>A	c.(2221-2223)Cgc>Agc	p.R741S	NWD1_ENST00000379808.3_Missense_Mutation_p.R741S|NWD1_ENST00000339803.6_Missense_Mutation_p.R606S|NWD1_ENST00000552788.1_Missense_Mutation_p.R741S|NWD1_ENST00000549814.1_Missense_Mutation_p.R741S|NWD1_ENST00000523826.1_Missense_Mutation_p.R535S	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	741							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCACTCGGGCCGCCTGGAGGA	0.612000													14	45					7.93312e-07	9.56372e-07	1	1	0
TTC7B	145567	broad.mit.edu	37	14	91196419	91196419	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:91196419C>A	ENST00000357056.2	-	5	819	c.698_splice	c.e5+1	p.G233_splice	TTC7B_ENST00000328459.6_Splice_Site_p.G233_splice			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	233							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				GATGGCTTACCCATTTTTGAA	0.388000													24	41					2.49675e-24	4.40305e-24	1	1	0
TCERG1	10915	broad.mit.edu	37	5	145843189	145843189	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:145843189C>T	ENST00000296702.5	+	5	1006	c.968C>T	c.(967-969)gCt>gTt	p.A323V	TCERG1_ENST00000394421.2_Missense_Mutation_p.A323V	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	323	Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAACTCCTGCTCCTACAGCC	0.488000													14	135					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50944254	50944254	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:50944254C>G	ENST00000357701.5	+	8	741	c.690C>G	c.(688-690)gcC>gcG	p.A230A		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	230					cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		AGAAAATCGCCTTCCAGTATG	0.542000													6	14					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95164334	95164334	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:95164334C>G	ENST00000027335.3	-	13	1682	c.1558G>C	c.(1558-1560)Gat>Cat	p.D520H	CDH17_ENST00000450165.2_Missense_Mutation_p.D520H|CDH17_ENST00000441892.2_Missense_Mutation_p.D306H	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	520	Cadherin 5.					integral to membrane	calcium ion binding	p.D520H(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTTTCAAAATCAAGAGGCTGT	0.373000													3	48					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70509696	70509696	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:70509696A>T	ENST00000035383.5	+	20	3945	c.3915A>T	c.(3913-3915)tcA>tcT	p.S1305S	LRRC7_ENST00000415775.2_Silent_p.S589S|LRRC7_ENST00000310961.5_Intron	NM_020794.2	NP_065845.1	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1305						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GAGGTATTTCAGCAATGCATG	0.408000													18	56					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102753033	102753033	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:102753033G>C	ENST00000311916.2	+	5	2006	c.1821G>C	c.(1819-1821)aaG>aaC	p.K607N	C10orf2_ENST00000473656.1_3'UTR|C10orf2_ENST00000370228.1_3'UTR	NM_001163813.1|NM_021830.4	NP_001157285.1|NP_068602.2	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	607	SF4 helicase.				cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGTGTCCAAGAACCGCTTTG	0.542000													10	131					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961213	34961213	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:34961213G>T	ENST00000329357.5	+	1	301	c.265G>T	c.(265-267)Gac>Tac	p.D89Y		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	89										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCCCCAAGCTGACCGCAAAAG	0.532000													29	56					2.81731e-10	3.83979e-10	1	1	0
PCDHB6	56130	broad.mit.edu	37	5	140531177	140531177	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140531177C>A	ENST00000231136.1	+	1	1339	c.1339C>A	c.(1339-1341)Ccc>Acc	p.P447T	PCDHB6_ENST00000543635.1_Missense_Mutation_p.P311T	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		447	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGACAACGTCCCCGCCTTCAC	0.572000													37	109					2.61675e-31	4.75939e-31	1	1	0
OR2Z1	284383	broad.mit.edu	37	19	8842168	8842168	+	Missense_Mutation	SNP	A	A	G	rs61746161	byFrequency	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:8842168A>G	ENST00000324060.2	+	1	853	c.778A>G	c.(778-780)Atg>Gtg	p.M260V		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTTCATGTACATGGTGCCTTG	0.552000													18	48					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603627	140603627	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140603627G>A	ENST00000239449.4	+	1	550	c.550G>A	c.(550-552)Gac>Aac	p.D184N	PCDHB14_ENST00000515856.2_Missense_Mutation_p.D31N	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		184	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAAAATTCCCGACAGTAGTGA	0.418000													23	43					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30129733	30129733	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:30129733G>A	ENST00000484663.1	-	2	1271	c.138C>T	c.(136-138)gcC>gcT	p.A46A	MAPK3_ENST00000263025.4_Silent_p.A160A|MAPK3_ENST00000403394.1_Silent_p.A160A|MAPK3_ENST00000395202.1_Silent_p.A160A|MAPK3_ENST00000395199.3_Silent_p.A160A|MAPK3_ENST00000395200.1_Silent_p.A131A|MAPK3_ENST00000322266.5_Silent_p.A160A			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	160	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GGAGCACGTTGGCGGAGTGGA	0.567000													4	82					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934221	4934221	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:4934221C>T	ENST00000345988.2	-	22	4524	c.4435G>A	c.(4435-4437)Gag>Aag	p.E1479K	PPL_ENST00000590782.2_Missense_Mutation_p.E1477K	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1479					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GTCTCGAGCTCCCCCTCCAGG	0.657000													5	75					0	0	1	0	0
KPNA3	3839	broad.mit.edu	37	13	50276609	50276609	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:50276609C>T	ENST00000261667.3	-	16	1794	c.1380G>A	c.(1378-1380)gaG>gaA	p.E460E		NM_002267.3	NP_002258.2	O00505	IMA3_HUMAN	karyopherin alpha 3 (importin alpha 4)	460					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity			cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(4)	21		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		CTTCAATTTTCTCCAAACCTG	0.279000													4	12					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921882	78921882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:78921882G>T	ENST00000261751.3	-	5	876	c.765C>A	c.(763-765)taC>taA	p.Y255*	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	255					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CGGATGGCAGGTAGAAGACGA	0.547000													26	86					9.57634e-11	1.32595e-10	1	1	0
KIAA1958	158405	broad.mit.edu	37	9	115422119	115422119	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:115422119C>T	ENST00000337530.6	+	4	2217	c.1921C>T	c.(1921-1923)Cgg>Tgg	p.R641W	KIAA1958_ENST00000536272.1_Missense_Mutation_p.R669W	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	641										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						GTACATCCACCGGCCGCCCAC	0.587000													3	29					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13063	13063	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrM:13063G>A	ENST00000361567.2	+	1	727	c.727G>A	c.(727-729)Gtc>Atc	p.V243I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	243					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	GCCCCACCCCAGTCTCAGCCC	0.547000													31	10					0	0	1	0	0
ALG10	84920	broad.mit.edu	37	12	34179612	34179612	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:34179612G>T	ENST00000266483.2	+	3	1503	c.1184G>T	c.(1183-1185)tGg>tTg	p.W395L	ALG10_ENST00000538927.1_Intron|RP11-847H18.2_ENST00000501954.2_RNA	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	395					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCAATTTTTTGGAATTTAATG	0.303000													17	51					5.35267e-07	6.48281e-07	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	6					0.000673444	0.000730848	1	1	0
CRB1	23418	broad.mit.edu	37	1	197390932	197390932	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:197390932C>A	ENST00000543483.1	+	6	1258	c.863C>A	c.(862-864)tCt>tAt	p.S288Y	CRB1_ENST00000367399.2_Silent_p.I546I|CRB1_ENST00000538660.1_Silent_p.I658I|CRB1_ENST00000535699.1_Silent_p.I589I|CRB1_ENST00000544212.1_Silent_p.I139I|CRB1_ENST00000367400.3_Silent_p.I658I|CRB1_ENST00000367397.1_Silent_p.I39I			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	0	EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGGAGAACATCTCGTCTGGCT	0.443000													24	98					1.55469e-16	2.53609e-16	1	1	0
KIAA1644	85352	broad.mit.edu	37	22	44692609	44692609	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr22:44692609T>A	ENST00000381176.4	-	3	356	c.224A>T	c.(223-225)gAg>gTg	p.E75V		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	75						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				CGCCTGGAACTCCGTCTCGTT	0.592000													34	138					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134143536	134143536	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:134143536G>A	ENST00000452510.2	+	16	2211	c.2053G>A	c.(2053-2055)Gtg>Atg	p.V685M	DDX46_ENST00000354283.4_Missense_Mutation_p.V685M	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	685	Helicase C-terminal.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGTCTAGATGTGAAACATCT	0.428000													11	33					0	0	1	0	0
PEBP1	5037	broad.mit.edu	37	12	118575880	118575880	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:118575880C>G	ENST00000261313.2	+	2	524	c.172C>G	c.(172-174)Ctt>Gtt	p.L58V		NM_002567.2	NP_002558.1	P30086	PEBP1_HUMAN	phosphatidylethanolamine binding protein 1	58							ATP binding|phosphatidylethanolamine binding|serine-type endopeptidase inhibitor activity	p.L58V(1)		ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGGGATGGTCTTGATTCAGG	0.493000													3	26					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34203957	34203957	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:34203957C>T	ENST00000374273.3	+	1	144	c.32C>T	c.(31-33)tCg>tTg	p.S11L		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	11					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GGCTCGGCCTCGTCCTCGCGC	0.677000													18	20					0	0	1	0	0
MSRB2	22921	broad.mit.edu	37	10	23408279	23408279	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:23408279G>T	ENST00000376510.3	+	4	446	c.343G>T	c.(343-345)Gag>Tag	p.E115*	MSRB2_ENST00000468633.1_3'UTR	NM_012228.3	NP_036360.3	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2	115					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	9					L-Methionine(DB00134)	TTCGTTTTCCGAGGCTCATGG	0.498000													17	46					1.67942e-08	2.15925e-08	1	1	0
ZNF18	7566	broad.mit.edu	37	17	11881681	11881681	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:11881681T>A	ENST00000322748.3	-	9	1847	c.1243A>T	c.(1243-1245)Aag>Tag	p.K415*	ZNF18_ENST00000580306.1_Nonsense_Mutation_p.K415*|ZNF18_ENST00000454073.3_Nonsense_Mutation_p.K414*|ZNF18_ENST00000580613.1_Intron	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	415					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		TAAAAGGTCTTCCCACACTCC	0.517000													27	31					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7766919	7766919	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:7766919G>T	ENST00000338316.4	+	17	2303	c.2214_splice	c.e17+1	p.P738_splice	ADCY2_ENST00000537121.1_Splice_Site_p.P558_splice	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	738					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TTTTCCTCCCGGTAAGAACAT	0.423000													43	175					2.01807e-28	3.63252e-28	1	1	0
KCNE1	3753	broad.mit.edu	37	21	35821695	35821695	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:35821695C>T	ENST00000337385.3	-	3	613	c.238G>A	c.(238-240)Gtc>Atc	p.V80I	KCNE1_ENST00000399286.2_Missense_Mutation_p.V80I|KCNE1_ENST00000416357.2_Missense_Mutation_p.V80I|KCNE1_ENST00000399289.3_Missense_Mutation_p.V80I|KCNE1_ENST00000399284.1_Missense_Mutation_p.V80I|KCNE1_ENST00000432085.1_Missense_Mutation_p.V80I	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	80					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	TCGATGTAGACGTTGAATGGG	0.552000													22	33					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28887798	28887798	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:28887798C>A	ENST00000377199.3	-	3	1094	c.738G>T	c.(736-738)gaG>gaT	p.E246D	TRIM27_ENST00000377194.3_Missense_Mutation_p.E246D|TRIM27_ENST00000498117.1_5'UTR	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	246					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						CCTGCAGGAGCTCCCTGGTGG	0.547000			T	RET	papillary thyroid								21	70					1.28384e-07	1.58807e-07	1	1	0
PPL	5493	broad.mit.edu	37	16	4935596	4935596	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:4935596C>A	ENST00000345988.2	-	22	3149	c.3060G>T	c.(3058-3060)ctG>ctT	p.L1020L	PPL_ENST00000590782.2_Silent_p.L1018L	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1020					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TCTGCCGCCTCAGTGCCTCCA	0.687000													26	58					7.92952e-12	1.13403e-11	1	1	0
COIL	8161	broad.mit.edu	37	17	55027858	55027858	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:55027858C>A	ENST00000240316.4	-	2	779	c.745G>T	c.(745-747)Gag>Tag	p.E249*		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	249	2 X 4 AA repeats of A-R-N-S.|Ser/Thr-rich.					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					GATTCAGACTCCGAGGAGGAA	0.428000													18	42					1.01871e-10	1.40308e-10	1	1	0
HYDIN	54768	broad.mit.edu	37	16	71098635	71098635	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:71098635G>A	ENST00000393567.2	-	16	2334	c.2184C>T	c.(2182-2184)ctC>ctT	p.L728L	HYDIN_ENST00000448691.1_Silent_p.L728L|HYDIN_ENST00000448089.2_Silent_p.L728L|HYDIN_ENST00000541601.1_Silent_p.L745L|HYDIN_ENST00000538248.1_Silent_p.L755L|HYDIN_ENST00000321489.5_Silent_p.L728L	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	728										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGAATCCTGGGAGGTCATCTT	0.468000													6	22					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21914211	21914211	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:21914211G>C	ENST00000319481.3	-	6	684	c.478C>G	c.(478-480)Ctg>Gtg	p.L160V		NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	160					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TGTTTTACCAGAGCTGTGAGT	0.328000													6	29					0	0	1	0	0
PEPD	5184	broad.mit.edu	37	19	34003636	34003636	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:34003636G>T	ENST00000244137.6	-	2	97	c.64C>A	c.(64-66)Ctc>Atc	p.L22I	PEPD_ENST00000436370.3_Missense_Mutation_p.L22I|PEPD_ENST00000397032.4_Missense_Mutation_p.L22I	NM_000285.3	NP_000276.2	P12955	PEPD_HUMAN	peptidase D	22					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	17	Esophageal squamous(110;0.137)					AAGGCAAAGAGCGCCAGCGGC	0.632000													13	33					4.36969e-10	5.894e-10	1	1	0
BCORL1	63035	broad.mit.edu	37	X	129149417	129149417	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:129149417G>A	ENST00000540052.1	+	3	2713	c.2669G>A	c.(2668-2670)cGg>cAg	p.R890Q	BCORL1_ENST00000303743.5_Missense_Mutation_p.R890Q|BCORL1_ENST00000218147.7_Missense_Mutation_p.R890Q|BCORL1_ENST00000359304.2_Missense_Mutation_p.R890Q	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	890					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GGGCAACCACGGCCTGGGGGC	0.577000													14	52					0	0	1	0	0
JSRP1	126306	broad.mit.edu	37	19	2252613	2252613	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:2252613C>G	ENST00000300961.5	-	7	775	c.711G>C	c.(709-711)gaG>gaC	p.E237D	JSRP1_ENST00000586471.1_Missense_Mutation_p.E237D	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	237	Arg-rich.					sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGAGGCCTCTCCTTGGGTC	0.687000													12	61					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254525	30254525	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:30254525G>T	ENST00000361644.2	+	5	1221	c.484G>T	c.(484-486)Gtg>Ttg	p.V162L	MAGEB3_ENST00000378986.1_Missense_Mutation_p.V162L	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	162	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CAACATGGAGGTGGTATTTGG	0.393000													15	32					0.000219431	0.000243709	1	1	0
ATP11B	23200	broad.mit.edu	37	3	182591803	182591803	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:182591803G>T	ENST00000323116.5	+	19	2512	c.2252_splice	c.e19+1	p.R751_splice		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	751					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			CTTGCCAGAAGGTAAGAATAT	0.433000													6	13					0.00116845	0.00124985	1	1	0
EBF1	1879	broad.mit.edu	37	5	158523361	158523361	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:158523361G>C	ENST00000313708.6	-	3	627	c.345C>G	c.(343-345)ctC>ctG	p.L115L	EBF1_ENST00000517373.1_Silent_p.L115L|EBF1_ENST00000380654.4_Silent_p.L115L|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	115					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATTGCTGTAGAGAAGCTGAA	0.592000			T	HMGA2	lipoma								3	22					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15850236	15850236	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:15850236C>A	ENST00000338282.6	-	14	1817	c.1711G>T	c.(1711-1713)Gac>Tac	p.D571Y	MYH11_ENST00000452625.2_Missense_Mutation_p.D578Y|MYH11_ENST00000396324.3_Missense_Mutation_p.D578Y|MYH11_ENST00000300036.5_Missense_Mutation_p.D571Y|MYH11_ENST00000576790.1_Missense_Mutation_p.D571Y	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	571	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TCAGTCTTGTCCTTGAGCTGC	0.597000			T	CBFB	AML						OREG0023636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	35					4.3838e-07	5.32173e-07	1	1	0
OR2F2	135948	broad.mit.edu	37	7	143632559	143632559	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:143632559C>A	ENST00000408955.2	+	1	301	c.234C>A	c.(232-234)gtC>gtA	p.V78V		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CAAGCGTAGTCCCCCAGCTGC	0.512000													65	174					3.86735e-44	7.26171e-44	1	1	0
PITPNM2	57605	broad.mit.edu	37	12	123474421	123474421	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:123474421T>G	ENST00000320201.4	-	17	2782	c.2644A>C	c.(2644-2646)Acc>Ccc	p.T882P	PITPNM2_ENST00000280562.5_Intron|PITPNM2_ENST00000392428.1_Missense_Mutation_p.T603P|PITPNM2_ENST00000542749.1_Missense_Mutation_p.T882P	NM_020845.2	NP_065896.1	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	882	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCAGGGGTGGTGGGGCTGGGG	0.687000													10	23					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108818286	108818286	+	Missense_Mutation	SNP	A	A	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:108818286A>C	ENST00000232603.5	-	6	424	c.342T>G	c.(340-342)ttT>ttG	p.F114L	MORC1_ENST00000483760.1_Missense_Mutation_p.F114L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	114					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TAAAAAGAATAAAGTCTTTTC	0.343000													3	11					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145843190	145843190	+	Silent	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:145843190T>G	ENST00000296702.5	+	5	1007	c.969T>G	c.(967-969)gcT>gcG	p.A323A	TCERG1_ENST00000394421.2_Silent_p.A323A	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	323	Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAACTCCTGCTCCTACAGCCA	0.493000													14	137					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144296999	144296999	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:144296999C>A	ENST00000330824.2	+	3	368	c.293C>A	c.(292-294)aCc>aAc	p.T98N		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	98	UPAR/Ly6.				cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CACGGGAACACCGGTAAGTGG	0.677000													9	28					1.12685e-05	1.31298e-05	1	1	0
TIAM2	26230	broad.mit.edu	37	6	155450943	155450943	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:155450943C>A	ENST00000461783.3	+	6	1859	c.586C>A	c.(586-588)Cag>Aag	p.Q196K	TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000456144.1_Missense_Mutation_p.Q196K|TIAM2_ENST00000360366.4_Missense_Mutation_p.Q196K|TIAM2_ENST00000529824.2_Missense_Mutation_p.Q196K|TIAM2_ENST00000318981.5_Missense_Mutation_p.Q196K			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	196					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGAGCCGGTGCAGCTGCTGAG	0.607000													11	24					2.61681e-11	3.68188e-11	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2832025	2832025	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:2832025C>G	ENST00000602557.1	-	57	9246	c.8691G>C	c.(8689-8691)acG>acC	p.T2897T	CSMD1_ENST00000520002.1_Silent_p.T2897T|CSMD1_ENST00000400186.3_Silent_p.T2839T|CSMD1_ENST00000537824.1_Silent_p.T2896T|CSMD1_ENST00000542608.1_Silent_p.T2838T|CSMD1_ENST00000602723.1_Silent_p.T2839T			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2897	Sushi 21.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGCACACTCTCGTGTCGTTGC	0.572000													9	9					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10165759	10165759	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:10165759A>G	ENST00000377157.3	+	6	1479	c.418A>G	c.(418-420)Atg>Gtg	p.M140V	UBE4B_ENST00000343090.6_Missense_Mutation_p.M256V|UBE4B_ENST00000253251.8_Missense_Mutation_p.M256V	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	382					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AACAAGCCCCATGTTCTGCAG	0.493000													9	39					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31625383	31625383	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:31625383C>A	ENST00000349552.1	+	8	685	c.685C>A	c.(685-687)Caa>Aaa	p.Q229K		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	229						extracellular region	lipid binding										GGTGCAGCAGCAAAAGGGCAA	0.607000													24	47					3.73148e-12	5.45611e-12	1	1	0
SMG1	23049	broad.mit.edu	37	16	18849510	18849510	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:18849510C>A	ENST00000446231.2	-	45	7651	c.7239G>T	c.(7237-7239)ctG>ctT	p.L2413L	SMG1_ENST00000389467.3_Silent_p.L2413L			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2413	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AGGCCTCCAGCAGCGTCAGCA	0.537000													4	14					0.00116845	0.00124985	1	1	0
ALOX12B	242	broad.mit.edu	37	17	7984442	7984442	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:7984442G>T	ENST00000319144.4	-	3	676	c.416C>A	c.(415-417)gCc>gAc	p.A139D	AC129492.6_ENST00000399413.3_3'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	139	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GTCCTGCTTGGCTCTGATCTC	0.632000										Multiple Myeloma(8;0.094)			16	26					3.5997e-14	5.5266e-14	1	1	0
MAGEB18	286514	broad.mit.edu	37	X	26157161	26157161	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:26157161G>T	ENST00000325250.1	+	2	246	c.59G>T	c.(58-60)tGt>tTt	p.C20F		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	20							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						CAGGCTCGTTGTGAGAATCAG	0.537000													17	35					4.75885e-15	7.41528e-15	1	1	0
TTLL11	158135	broad.mit.edu	37	9	124855658	124855658	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:124855658C>T	ENST00000321582.5	-	1	227	c.40G>A	c.(40-42)Gca>Aca	p.A14T	TTLL11_ENST00000373776.3_Missense_Mutation_p.A14T	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	14					protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						GGCGAGGCTGCCCACGTGACC	0.692000													6	12					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627197	21627197	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:21627197C>A	ENST00000425654.2	+	19	2544	c.2064C>A	c.(2062-2064)tgC>tgA	p.C688*	CNKSR2_ENST00000379510.3_Nonsense_Mutation_p.C718*|CNKSR2_ENST00000543067.1_Nonsense_Mutation_p.C669*|CNKSR2_ENST00000279451.4_Nonsense_Mutation_p.C718*	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	718					regulation of signal transduction	cytoplasm|membrane	protein binding	p.C718C(1)		breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AGATGAGTTGCGCCAGTCCTT	0.458000													11	24					6.40141e-05	7.24845e-05	1	1	0
LAMA3	3909	broad.mit.edu	37	18	21508596	21508596	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:21508596G>T	ENST00000313654.9	+	64	8544	c.8303G>T	c.(8302-8304)cGa>cTa	p.R2768L	LAMA3_ENST00000399516.3_Missense_Mutation_p.R2712L|LAMA3_ENST00000269217.6_Missense_Mutation_p.R1159L|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.R1103L	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2768	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.R2768L(1)|p.R1159L(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCTTGTGCGATCTGCCTCA	0.418000													37	123					2.19962e-31	4.0147e-31	1	1	0
PRODH2	58510	broad.mit.edu	37	19	36303452	36303452	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:36303452C>A	ENST00000301175.3	-	3	426	c.409G>T	c.(409-411)Gcc>Tcc	p.A137S		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	137					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGAGACCAGGCCTGGAGCTGG	0.637000													12	12					0.411799	0.414979	1	1	0
TNR	7143	broad.mit.edu	37	1	175372661	175372661	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:175372661C>A	ENST00000367674.1	-	4	1299	c.591G>T	c.(589-591)aaG>aaT	p.K197N	TNR_ENST00000263525.2_Missense_Mutation_p.K197N	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	197	Cys-rich.|EGF-like 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CCGAGCAATTCTTGCCAAACC	0.577000													57	178					5.19286e-32	9.54462e-32	1	1	0
PPP1R3F	89801	broad.mit.edu	37	X	49138527	49138527	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:49138527G>T	ENST00000055335.6	+	3	1159		c.e3+1		PPP1R3F_ENST00000466508.1_Splice_Site|PPP1R3F_ENST00000495799.1_Splice_Site|PPP1R3F_ENST00000438316.1_Splice_Site|PPP1R3F_ENST00000376188.1_Splice_Site	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F							integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					GACACTTCAGGTAAGTGGGTC	0.592000													10	22					0.000673444	0.000730848	1	1	0
CCDC74A	90557	broad.mit.edu	37	2	132290881	132290881	+	Silent	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:132290881A>G	ENST00000295171.6	+	8	1185	c.1047A>G	c.(1045-1047)gcA>gcG	p.A349A	CCDC74A_ENST00000409856.3_Silent_p.A283A|CCDC74A_ENST00000467992.2_3'UTR	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	349										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						TCCTGCCCGCACTGAAGCAGA	0.637000													13	20					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432857	73432857	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:73432857G>C	ENST00000263666.4	-	10	2974	c.2860C>G	c.(2860-2862)Cgc>Ggc	p.R954G	PDZRN3_ENST00000535920.1_Missense_Mutation_p.R676G|PDZRN3_ENST00000462146.2_Missense_Mutation_p.R611G|PDZRN3_ENST00000479530.1_Missense_Mutation_p.R671G|PDZRN3_ENST00000466780.1_Missense_Mutation_p.R611G	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	954							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ATGCCGCTGCGCTCTTCCCGG	0.657000													14	40					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62148676	62148676	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:62148676C>A	ENST00000416284.3	-	3	1820	c.236G>T	c.(235-237)cGa>cTa	p.R79L	FAM19A2_ENST00000551619.1_Missense_Mutation_p.R79L|FAM19A2_ENST00000551449.1_Intron|FAM19A2_ENST00000550003.1_5'UTR	NM_178539.4	NP_848634.1	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	79						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		TGGAGCAGCTCGCGTGGTGCC	0.502000													8	42					0.000442599	0.000486393	1	1	0
ELMO2	63916	broad.mit.edu	37	20	45003949	45003949	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:45003949T>C	ENST00000372176.1	-	13	1195	c.727A>G	c.(727-729)Agc>Ggc	p.S243G	ELMO2_ENST00000439931.2_Missense_Mutation_p.S343G|ELMO2_ENST00000454865.2_Missense_Mutation_p.S63G|ELMO2_ENST00000488853.1_5'UTR|ELMO2_ENST00000396391.1_Missense_Mutation_p.S331G|ELMO2_ENST00000290246.6_Missense_Mutation_p.S331G|ELMO2_ENST00000352077.2_Missense_Mutation_p.S329G|ELMO2_ENST00000445496.2_Missense_Mutation_p.S148G			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	331					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				GGGGCATTGCTAGGATCAGAC	0.488000													20	49					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75648363	75648363	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:75648363C>T	ENST00000361470.2	+	1	318	c.40C>T	c.(40-42)Cgc>Tgc	p.R14C		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	14	Poly-Arg.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						ccgccgccgccgcgTTGCAAA	0.667000													5	17					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2933093	2933093	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:2933093C>T	ENST00000381130.2	+	4	423	c.423C>T	c.(421-423)taC>taT	p.Y141Y		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	141						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				ACTACTTTTACGGGGTGCCTT	0.498000													8	21					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274009	10274009	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:10274009C>A	ENST00000396573.2	-	3	569	c.260G>T	c.(259-261)tGc>tTc	p.C87F	GRIN2A_ENST00000330684.3_Missense_Mutation_p.C87F|GRIN2A_ENST00000396575.2_Missense_Mutation_p.C87F|GRIN2A_ENST00000404927.2_Missense_Mutation_p.C87F|GRIN2A_ENST00000562109.1_Missense_Mutation_p.C87F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	87					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CATGAGGTCGCACACGTGCGT	0.657000													26	77					1.74807e-11	2.46619e-11	1	1	0
S100B	6285	broad.mit.edu	37	21	48022263	48022263	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:48022263C>A	ENST00000367071.4	-	2	262	c.66G>T	c.(64-66)gaG>gaT	p.E22D	S100B_ENST00000291700.4_Missense_Mutation_p.E22D|S100B_ENST00000397648.1_Missense_Mutation_p.E22D			P04271	S100B_HUMAN	S100 calcium binding protein B	22	EF-hand 1.				axonogenesis|cell proliferation|central nervous system development|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular region|nucleus|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|RAGE receptor binding|S100 beta binding|tau protein binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5	Breast(49;0.247)	Lung NSC(3;0.245)		OV - Ovarian serous cystadenocarcinoma(3;1.84e-06)|Epithelial(3;4.45e-06)|all cancers(3;2.07e-05)|Colorectal(79;0.241)		GCTTGTCTCCCTCCCTTCCAG	0.478000													10	31					0.00621372	0.00650012	1	1	0
FSTL5	56884	broad.mit.edu	37	4	162380377	162380377	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:162380377G>T	ENST00000306100.5	-	14	2139	c.1703C>A	c.(1702-1704)tCa>tAa	p.S568*	FSTL5_ENST00000536695.1_Nonsense_Mutation_p.S567*|FSTL5_ENST00000379164.4_Nonsense_Mutation_p.S567*|FSTL5_ENST00000427802.2_Nonsense_Mutation_p.S558*	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	568						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TAGTGTTGGTGATGTCTTCTC	0.373000													18	34					1.36565e-18	2.29218e-18	1	1	0
DUSP7	1849	broad.mit.edu	37	3	52090174	52090174	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:52090174G>A	ENST00000495880.1	-	1	392	c.209C>T	c.(208-210)gCg>gTg	p.A70V	DUSP7_ENST00000296483.6_Missense_Mutation_p.A19V			Q16829	DUS7_HUMAN	dual specificity phosphatase 7	70	Rhodanese.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CAGCAAGGACGCGCCGCCGCG	0.741000													8	8					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166396	140166396	+	Missense_Mutation	SNP	C	C	A	rs141972872		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140166396C>A	ENST00000504120.2	+	1	521	c.521C>A	c.(520-522)cCg>cAg	p.P174Q	PCDHA1_ENST00000394633.3_Missense_Mutation_p.P174Q|PCDHA1_ENST00000378133.3_Missense_Mutation_p.P174Q	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCTCAGCCCGAGTGATTAT	0.413000													16	34					1.15088e-07	1.42698e-07	1	1	0
RNASE12	493901	broad.mit.edu	37	14	21058461	21058461	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:21058461C>G	ENST00000556526.1	-	1	521	c.422G>C	c.(421-423)aGt>aCt	p.S141T	AL163195.3_ENST00000555283.1_RNA|RP11-14J7.6_ENST00000554529.1_RNA|RP11-14J7.6_ENST00000556487.1_RNA|RP11-14J7.6_ENST00000553604.1_RNA|RNASE11_ENST00000335950.4_5'UTR	NM_001024822.2	NP_001019993.1	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	141						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			kidney(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		GCCAAGGAAACTATCTGGCCT	0.502000													15	14					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44777052	44777052	+	Splice_Site	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:44777052G>A	ENST00000592581.1	+	5	528	c.420_splice	c.e5-1	p.*141_splice	ZNF233_ENST00000334152.1_Intron|ZNF233_ENST00000391958.2_Splice_Site_p.G80_splice|ZNF235_ENST00000589799.1_Intron	NM_001207005.1	NP_001193934.1	A6NK53	ZN233_HUMAN	zinc finger protein 233	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				ATCATTCTAGGACACAAGAAT	0.323000													6	20					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54581635	54581635	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:54581635C>A	ENST00000251636.5	-	9	1269	c.1121G>T	c.(1120-1122)tGg>tTg	p.W374L	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	374							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTCCAGTCCAACTTCGAGC	0.348000													5	22					0.0215528	0.0220599	1	1	0
DENND4C	55667	broad.mit.edu	37	9	19316466	19316466	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:19316466C>T	ENST00000380432.2	+	7	864	c.831C>T	c.(829-831)tgC>tgT	p.C277C	DENND4C_ENST00000307015.9_5'UTR|DENND4C_ENST00000602925.1_Silent_p.C513C|DENND4C_ENST00000434457.2_Silent_p.C513C	NM_017925.4	NP_060395.5	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	277						integral to membrane		p.C277W(1)		breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						AAAAGCCGTGCAAAAATCTAC	0.328000													15	12					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56585389	56585389	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:56585389C>G	ENST00000267460.4	+	1	297	c.11C>G	c.(10-12)cCt>cGt	p.P4R		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	4					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						ATGTTTTCCCCTGGCCAGGAG	0.726000													3	5					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848130	54848130	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:54848130G>A	ENST00000291759.4	-	6	1293	c.1237C>T	c.(1237-1239)Ctg>Ttg	p.L413L	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	413	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		ACGAGCTCCAGGGGCTCACTG	0.597000													24	46					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579310	7579310	+	Splice_Site	SNP	A	A	T	rs68140816		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:7579310A>T	ENST00000420246.2	-	4	508		c.e4+1		TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000269305.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.?(5)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGCAACTGACCGTGCAAGT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	50					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254096	30254096	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:30254096C>A	ENST00000361644.2	+	5	792	c.55C>A	c.(55-57)Cgg>Agg	p.R19R	MAGEB3_ENST00000378986.1_Silent_p.R19R	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	19										NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CCAGCAGACCCGGGGTCAGAC	0.532000													14	45					6.31663e-08	7.96444e-08	1	1	0
BNC1	646	broad.mit.edu	37	15	83926689	83926689	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:83926689C>A	ENST00000345382.2	-	5	2575	c.2490G>T	c.(2488-2490)ctG>ctT	p.L830L	BNC1_ENST00000569704.1_Silent_p.L823L|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	830					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TTGGGTAAACCAGACTGCCCA	0.517000													21	73					1.42536e-11	2.02735e-11	1	1	0
TADA1	117143	broad.mit.edu	37	1	166839015	166839015	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:166839015G>A	ENST00000367874.4	-	2	244	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F		NM_053053.3	NP_444281.1	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1	51					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity	p.L51F(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	11						TCCTGTGTGAGAAGTCTATGA	0.353000													6	99					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248262809	248262809	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248262809G>C	ENST00000366478.2	+	3	469	c.132G>C	c.(130-132)atG>atC	p.M44I	OR2L13_ENST00000358120.2_Missense_Mutation_p.M44I	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ACTCGGCCATGATTCACCTCA	0.493000													86	89					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80831229	80831229	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:80831229T>A	ENST00000466387.1	+	20	2944	c.2220T>A	c.(2218-2220)gaT>gaA	p.D740E	CTNNA2_ENST00000541047.1_Missense_Mutation_p.D740E|AC008067.2_ENST00000596887.1_RNA|CTNNA2_ENST00000402739.4_Missense_Mutation_p.D740E|CTNNA2_ENST00000496558.1_Missense_Mutation_p.D740E|CTNNA2_ENST00000343114.3_Missense_Mutation_p.D419E|AC008067.2_ENST00000595478.1_RNA|CTNNA2_ENST00000540488.1_Missense_Mutation_p.D740E|AC008067.2_ENST00000430876.1_RNA|AC008067.2_ENST00000599412.1_RNA|CTNNA2_ENST00000361291.4_Missense_Mutation_p.D774E|AC008067.2_ENST00000596783.1_RNA			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	740					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						ATACATCTGATGTCATTAATG	0.423000													15	28					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56203726	56203726	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:56203726C>A	ENST00000361673.3	-	5	3906	c.3693G>T	c.(3691-3693)gaG>gaT	p.E1231D	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1231							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGTTGCCTGCCTCCCAATTTC	0.468000													23	78					6.44725e-10	8.67388e-10	1	1	0
OCIAD2	132299	broad.mit.edu	37	4	48899870	48899870	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:48899870C>T	ENST00000508632.1	-	4	400	c.168G>A	c.(166-168)ctG>ctA	p.L56L	OCIAD2_ENST00000508069.2_5'UTR|OCIAD2_ENST00000273860.4_Silent_p.L56L	NM_001014446.1	NP_001014446.1	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2	56	OCIA.					endosome				kidney(1)|lung(3)|skin(1)|urinary_tract(1)	6						GAGAAAAAGGCAGAGCTGTAA	0.353000													7	31					0	0	1	0	0
TFDP3	51270	broad.mit.edu	37	X	132351379	132351379	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:132351379C>T	ENST00000310125.4	-	1	997	c.909G>A	c.(907-909)ggG>ggA	p.G303G		NM_016521.2	NP_057605.3	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	303	DCB2 (By similarity).|Involved in negatively regulating E2F activity.					transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(1)|lung(8)|ovary(1)|prostate(2)	19	Acute lymphoblastic leukemia(192;0.000127)					CGGACTCTAGCCCAAAAGTCA	0.483000													17	49					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	891884	891884	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:891884C>A	ENST00000314167.4	-	6	698	c.588G>T	c.(586-588)acG>acT	p.T196T	GAK_ENST00000511163.1_Silent_p.T117T	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	196	Protein kinase.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GCGAGATGGTCGTGGCACTGC	0.567000													10	21					6.40141e-05	7.24845e-05	1	1	0
CAPN3	825	broad.mit.edu	37	15	42676714	42676714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:42676714G>T	ENST00000397163.3	+	2	562	c.343G>T	c.(343-345)Gga>Tga	p.G115*	CAPN3_ENST00000318023.7_Nonsense_Mutation_p.G115*|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000357568.3_Nonsense_Mutation_p.G115*|CAPN3_ENST00000356316.3_Nonsense_Mutation_p.G28*|CAPN3_ENST00000349748.3_Nonsense_Mutation_p.G115*	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	115	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TATCATTGATGGAGCCAACAG	0.428000													16	37					3.32936e-07	4.07008e-07	1	1	0
MTM1	4534	broad.mit.edu	37	X	149761086	149761086	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:149761086G>T	ENST00000370396.2	+	2	64	c.10G>T	c.(10-12)Gca>Tca	p.A4S	MTM1_ENST00000413012.2_Missense_Mutation_p.A4S|MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000543350.1_5'UTR|MTM1_ENST00000542741.1_5'UTR	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	4					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					GATGGCTTCTGCATCAACTTC	0.328000													21	44					7.92952e-12	1.13403e-11	1	1	0
LRP2	4036	broad.mit.edu	37	2	170062546	170062546	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:170062546C>A	ENST00000263816.3	-	40	7828	c.7543G>T	c.(7543-7545)Gat>Tat	p.D2515Y		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2515					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGGCAGGGATCTAACACAATT	0.423000													33	104					3.62531e-18	6.04604e-18	1	1	0
ZNF445	353274	broad.mit.edu	37	3	44488733	44488733	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:44488733C>A	ENST00000425708.2	-	7	2771	c.2430G>T	c.(2428-2430)agG>agT	p.R810S	ZNF445_ENST00000396077.2_Missense_Mutation_p.R810S			P59923	ZN445_HUMAN	zinc finger protein 445	810					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GAGAGTGAATCCTCTGATGTC	0.443000													19	36					2.37509e-13	3.61457e-13	1	1	0
ZNF536	9745	broad.mit.edu	37	19	30935800	30935800	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:30935800C>A	ENST00000355537.3	+	2	1478	c.1331C>A	c.(1330-1332)gCc>gAc	p.A444D		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCGGACAAAGCCGGCCTGAGC	0.647000													15	33					5.01169e-05	5.71202e-05	1	1	0
ZNF304	57343	broad.mit.edu	37	19	57867768	57867768	+	Silent	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:57867768A>G	ENST00000391705.3	+	4	815	c.531A>G	c.(529-531)ccA>ccG	p.P177P	ZNF304_ENST00000598744.1_Silent_p.P135P|ZNF304_ENST00000282286.5_Silent_p.P177P|ZNF304_ENST00000443917.2_Silent_p.P224P	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TGGACTTACCAGATAGCTCTG	0.517000													17	44					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152937358	152937358	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:152937358C>A	ENST00000393831.2	-	5	825	c.391G>T	c.(391-393)Ggg>Tgg	p.G131W	PNCK_ENST00000447676.2_Missense_Mutation_p.G214W|PNCK_ENST00000370142.1_Missense_Mutation_p.G131W|PNCK_ENST00000340888.3_Missense_Mutation_p.G131W|PNCK_ENST00000475172.1_5'UTR|PNCK_ENST00000370145.4_Missense_Mutation_p.G148W|PNCK_ENST00000370150.1_Missense_Mutation_p.G131W	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	131	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCACGATCCCCAGGCTGTGC	0.662000													10	23					2.74318e-10	3.74853e-10	1	1	0
C1orf127	148345	broad.mit.edu	37	1	11007869	11007869	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:11007869C>A	ENST00000377004.4	-	12	2322	c.2323G>T	c.(2323-2325)Gtg>Ttg	p.V775L	C1orf127_ENST00000377008.4_Missense_Mutation_p.V608L	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	626										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		TCAAGCTCCACCAGGCTGGGT	0.652000													4	16					0.00909568	0.00947694	1	1	0
COL4A5	1287	broad.mit.edu	37	X	107811895	107811895	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:107811895G>C	ENST00000328300.6	+	5	557	c.313G>C	c.(313-315)Ggt>Cgt	p.G105R	COL4A5_ENST00000361603.2_Missense_Mutation_p.G105R	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	105	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						AGGGACACCAGGTCTTCCTGT	0.343000									Alport syndrome with Diffuse Leiomyomatosis				9	54					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43249312	43249312	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:43249312G>T	ENST00000255226.6	+	16	2894	c.2078G>T	c.(2077-2079)tGg>tTg	p.W693L	SLC14A2_ENST00000586448.1_Missense_Mutation_p.W693L|SLC14A2_ENST00000589658.1_Missense_Mutation_p.W170L	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	693						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCAGCAAGTGGGACCTCCCA	0.552000													55	139					3.77215e-22	6.56355e-22	1	1	0
PADI1	29943	broad.mit.edu	37	1	17556647	17556647	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:17556647A>G	ENST00000375471.4	+	9	1089	c.997A>G	c.(997-999)Aac>Gac	p.N333D		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	333					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ATTGAAAGCCAACTGCAAGCT	0.527000													15	58					0	0	1	0	0
SCMH1	22955	broad.mit.edu	37	1	41536268	41536268	+	Splice_Site	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:41536268T>A	ENST00000402904.2	-	10	1442	c.1075_splice	c.e10+1	p.T358_splice	SCMH1_ENST00000337495.5_Splice_Site_p.T368_splice|SCMH1_ENST00000326197.7_Splice_Site_p.T358_splice|SCMH1_ENST00000372597.1_Splice_Site_p.T311_splice|SCMH1_ENST00000397171.2_Splice_Site_p.T297_splice|SCMH1_ENST00000397174.2_Splice_Site_p.T338_splice|SCMH1_ENST00000372595.1_Splice_Site_p.T297_splice|SCMH1_ENST00000372596.1_Splice_Site_p.T297_splice|SCMH1_ENST00000361705.3_Splice_Site_p.T311_splice|SCMH1_ENST00000361191.5_Splice_Site_p.T297_splice|SCMH1_ENST00000456518.2_Splice_Site_p.T200_splice	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	358					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				TGCTCTTACCTGTTGGGGCCT	0.537000													24	68					0	0	1	0	0
VWA9	81556	broad.mit.edu	37	15	65899529	65899529	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:65899529C>T	ENST00000395644.4	-	2	525	c.190G>A	c.(190-192)Gtc>Atc	p.V64I	VWA9_ENST00000567744.1_Missense_Mutation_p.V100I|VWA9_ENST00000420799.2_Intron|VWA9_ENST00000313182.2_Missense_Mutation_p.V64I|VWA9_ENST00000431261.2_Intron|VWA9_ENST00000442903.3_Missense_Mutation_p.V64I|VWA9_ENST00000569491.1_Intron					von Willebrand factor A domain containing 9																		GTGAAGGGGACCATCAACTCC	0.388000													9	23					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711758	155711758	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:155711758G>T	ENST00000295101.2	+	3	1916	c.1439G>T	c.(1438-1440)gGa>gTa	p.G480V		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	480					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	ATGGCTGGAGGAGCAGCTAGG	0.423000													8	15					3.09899e-07	3.79735e-07	1	1	0
BAI2	576	broad.mit.edu	37	1	32222314	32222314	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:32222314C>A	ENST00000373658.3	-	4	465	c.124G>T	c.(124-126)Gcc>Tcc	p.A42S	BAI2_ENST00000398547.1_Missense_Mutation_p.A30S|BAI2_ENST00000257070.4_Missense_Mutation_p.A42S|BAI2_ENST00000398556.3_Missense_Mutation_p.A45S|BAI2_ENST00000373655.2_Missense_Mutation_p.A42S|BAI2_ENST00000398542.1_Missense_Mutation_p.A30S|BAI2_ENST00000527361.1_Missense_Mutation_p.A42S|BAI2_ENST00000398538.1_Missense_Mutation_p.A30S	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	42					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GAGGCCAGGGCAGAGCAGGCA	0.657000													4	9					1	1	1	1	0
ALG13	79868	broad.mit.edu	37	X	110951467	110951467	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:110951467C>A	ENST00000394780.3	+	4	608	c.596C>A	c.(595-597)cCc>cAc	p.P199H	ALG13_ENST00000251943.4_Missense_Mutation_p.P95H|ALG13-AS1_ENST00000430794.1_RNA	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	199					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						CCTCTTACCCCCACCCTGTAC	0.468000													11	31					1.08611e-07	1.34988e-07	1	1	0
AGT	183	broad.mit.edu	37	1	230846207	230846207	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:230846207C>A	ENST00000366667.4	-	2	604	c.390G>T	c.(388-390)ggG>ggT	p.G130G		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	130					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGACGGTGGCCCCATGGACCA	0.597000													31	103					2.42023e-17	3.99798e-17	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169468121	169468121	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:169468121C>A	ENST00000256935.8	+	37	3808	c.3728C>A	c.(3727-3729)aCg>aAg	p.T1243K	DOCK2_ENST00000540750.1_Missense_Mutation_p.T304K|DOCK2_ENST00000520908.1_Missense_Mutation_p.T735K|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1243	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGCCTACACGCTCCTTCTC	0.502000													12	42					0.000151284	0.000169102	1	1	0
GNG13	51764	broad.mit.edu	37	16	849032	849032	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:849032G>T	ENST00000248150.4	-	2	147	c.46C>A	c.(46-48)Ctc>Atc	p.L16I		NM_016541.2	NP_057625.1	Q9P2W3	GBG13_HUMAN	guanine nucleotide binding protein (G protein), gamma 13	16					cellular response to glucagon stimulus|energy reserve metabolic process		signal transducer activity			ovary(1)	1		Hepatocellular(780;0.00335)				TGGTACTTGAGGCTCTCCACC	0.622000													12	28					0.0202918	0.020851	1	1	0
C6orf195	154386	broad.mit.edu	37	6	2623839	2623839	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:2623839G>T	ENST00000296847.3	-	3	741	c.218C>A	c.(217-219)cCt>cAt	p.P73H		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	73										cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				AGATGGGGCAGGAACTGAGGG	0.622000													14	75					1.52009e-12	2.23518e-12	1	1	0
OR2T8	343172	broad.mit.edu	37	1	248085099	248085099	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248085099C>A	ENST00000319968.4	+	1	780	c.780C>A	c.(778-780)ccC>ccA	p.P260P		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ATATGAGACCCAAATCCCACA	0.488000													16	17					2.89027e-11	4.03401e-11	1	1	0
NHS	4810	broad.mit.edu	37	X	17746878	17746878	+	Silent	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:17746878A>G	ENST00000380060.3	+	7	4607	c.4269A>G	c.(4267-4269)ttA>ttG	p.L1423L	NHS_ENST00000398097.3_Silent_p.L1267L	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1423						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CTGAGGATTTATTTGCAGTCA	0.443000													20	53					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178699960	178699960	+	Silent	SNP	G	G	T	rs144732073		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:178699960G>T	ENST00000251582.7	-	3	741	c.640C>A	c.(640-642)Cgg>Agg	p.R214R	ADAMTS2_ENST00000274609.5_Silent_p.R214R	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	214					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTGGGTGGCCGGCGATACACC	0.662000													21	52					4.54149e-19	7.64728e-19	1	1	0
BRWD1	54014	broad.mit.edu	37	21	40559292	40559292	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:40559292T>A	ENST00000333229.2	-	42	6950	c.6623A>T	c.(6622-6624)cAt>cTt	p.H2208L		NM_018963.4	NP_061836.2	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	2208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CTTCTGATTATGCATACATGT	0.378000													16	27					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149809819	149809819	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:149809819G>C	ENST00000370396.2	+	8	660	c.606G>C	c.(604-606)ttG>ttC	p.L202F	MTM1_ENST00000413012.2_Missense_Mutation_p.L165F|MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000543350.1_Missense_Mutation_p.L87F|MTM1_ENST00000542741.1_Missense_Mutation_p.L107F	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	202	Myotubularin phosphatase.		L -> S (in XCNM; severe).		endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity	p.L202F(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTCTTTTGGTGGTTCCGT	0.428000													33	71					0	0	1	0	0
TTPA	7274	broad.mit.edu	37	8	63985591	63985591	+	Silent	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:63985591T>C	ENST00000260116.4	-	2	292	c.261A>G	c.(259-261)ctA>ctG	p.L87L	TTPA_ENST00000521138.1_Intron	NM_000370.3	NP_000361.1	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	87					lipid metabolic process		transporter activity|vitamin E binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)	15	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	TTCTAGGGTGTAGATCTGCAC	0.383000													9	28					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43089490	43089490	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:43089490C>A	ENST00000359467.3	-	5	1022	c.908G>T	c.(907-909)tGt>tTt	p.C303F	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	303						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						ACTTTCACCACAATCATAGTG	0.383000													23	60					9.95505e-16	1.57949e-15	1	1	0
DGKK	139189	broad.mit.edu	37	X	50121611	50121611	+	RNA	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:50121611G>A	ENST00000376025.2	-	0	3000							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTGATGATACGGGACATTGCC	0.542000													5	20					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166363	140166363	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140166363G>T	ENST00000504120.2	+	1	488	c.488G>T	c.(487-489)gGt>gTt	p.G163V	PCDHA1_ENST00000394633.3_Missense_Mutation_p.G163V|PCDHA1_ENST00000378133.3_Missense_Mutation_p.G163V	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGACATTGGTGCTAACGCT	0.443000													22	46					9.57634e-11	1.32595e-10	1	1	0
EYS	346007	broad.mit.edu	37	6	66115233	66115233	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:66115233G>T	ENST00000503581.1	-	6	1427	c.890C>A	c.(889-891)cCt>cAt	p.P297H	EYS_ENST00000342421.5_Missense_Mutation_p.P297H|EYS_ENST00000393380.2_Missense_Mutation_p.P297H|EYS_ENST00000370616.2_Missense_Mutation_p.P297H|EYS_ENST00000370618.3_Missense_Mutation_p.P297H|EYS_ENST00000370621.3_Missense_Mutation_p.P297H	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	297					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						AGAAACACAAGGTTTTGCTGA	0.368000													30	46					4.11147e-13	6.16721e-13	1	1	0
SEMA5A	9037	broad.mit.edu	37	5	9052006	9052006	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:9052006A>G	ENST00000382496.5	-	20	3489	c.2824T>C	c.(2824-2826)Ttt>Ctt	p.F942L		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	942	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TTAGAGTCAAACACACACGGC	0.507000													23	65					0	0	1	0	0
EMP3	2014	broad.mit.edu	37	19	48830119	48830119	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:48830119G>T	ENST00000270221.6	+	2	319	c.18G>T	c.(16-18)ctG>ctT	p.L6L	EMP3_ENST00000597279.1_Silent_p.L6L|EMP3_ENST00000596315.1_Intron	NM_001425.2	NP_001416.1	P54852	EMP3_HUMAN	epithelial membrane protein 3	6					cell growth|negative regulation of cell proliferation	integral to membrane				lung(1)	1		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		TCCTCTTGCTGGTGGTCTCAG	0.562000													53	155					6.75472e-32	1.23718e-31	1	1	0
C8A	731	broad.mit.edu	37	1	57383331	57383331	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:57383331C>T	ENST00000361249.3	+	11	1793	c.1697C>T	c.(1696-1698)gCa>gTa	p.A566V		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	566	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GACAATCCAGCACCTCAGAAT	0.582000													13	31					0	0	1	0	0
ZNF630	57232	broad.mit.edu	37	X	47917869	47917869	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:47917869C>G	ENST00000276054.4	-	5	2524	c.1590G>C	c.(1588-1590)ttG>ttC	p.L530F	ZNF630_ENST00000409324.3_Missense_Mutation_p.L654F|ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000442455.3_Missense_Mutation_p.L640F			Q2M218	ZN630_HUMAN	zinc finger protein 630	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						AGCATATATACAAGGTGTCTT	0.438000													14	36					0	0	1	0	0
MKRN2	23609	broad.mit.edu	37	3	12613724	12613724	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:12613724G>A	ENST00000170447.7	+	4	631	c.494G>A	c.(493-495)aGc>aAc	p.S165N	MKRN2_ENST00000448482.1_Missense_Mutation_p.S163N|MKRN2_ENST00000411987.1_Missense_Mutation_p.S122N	NM_001271707.1|NM_014160.3	NP_001258636.1|NP_054879.3	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	165						intracellular	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)	16						AGCTCCTACAGCAACGAGCAG	0.627000													18	35					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233464558	233464558	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:233464558C>T	ENST00000366624.3	+	1	1045	c.784C>T	c.(784-786)Cgg>Tgg	p.R262W	MLK4_ENST00000366623.3_Missense_Mutation_p.R262W	NM_032435.2	NP_115811.2																					CATCCTGCACCGGGACCTCAA	0.652000													3	16					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183079686	183079686	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:183079686T>A	ENST00000258341.4	+	4	1175	c.918T>A	c.(916-918)aaT>aaA	p.N306K		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	306	Laminin EGF-like 1.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGTGTGTAATTGCAAACATA	0.448000													69	106					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644576	20644576	+	RNA	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:20644576T>C	ENST00000428453.1	-	0	3187																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GCCACCCACCTCTGAGTGACG	0.612000													3	8					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105921783	105921783	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:105921783A>T	ENST00000357060.3	-	26	3465	c.3350T>A	c.(3349-3351)cTc>cAc	p.L1117H	WDR96_ENST00000428666.1_Missense_Mutation_p.L1118H	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1117										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CAGAGCTCGGAGTCTTGTACT	0.478000													72	169					0	0	1	0	0
TRBV9	28586	broad.mit.edu	37	7	142239828	142239828	+	RNA	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:142239828G>A	ENST00000390363.2	-	0	98																											GAATCCACTGGGCCTGTGTGT	0.512000													5	28					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11577656	11577656	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:11577656C>A	ENST00000294484.6	+	7	2024	c.1886C>A	c.(1885-1887)aCc>aAc	p.T629N	PTCHD2_ENST00000389575.3_Missense_Mutation_p.T629N	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	629					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCTGCCAGACCAGGTAAGTC	0.597000													11	24					4.3838e-07	5.32173e-07	1	1	0
TTBK1	84630	broad.mit.edu	37	6	43222290	43222290	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:43222290C>G	ENST00000259750.4	+	6	560	c.477C>G	c.(475-477)aaC>aaG	p.N159K	TTBK1_ENST00000304139.5_Missense_Mutation_p.N108K	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	159	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCCAGTCAAACTTTGCCATGG	0.642000													28	88					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97326820	97326820	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:97326820G>T	ENST00000558553.1	+	1	116		c.e1+1		SPATA8_ENST00000328504.3_5'UTR			Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8											large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GGATCCACTTGTGTGTCTTTC	0.582000													11	17					3.86212e-05	4.42111e-05	1	1	0
UPF3B	65109	broad.mit.edu	37	X	118972440	118972440	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:118972440T>A	ENST00000276201.2	-	9	966	c.897A>T	c.(895-897)gaA>gaT	p.E299D	UPF3B_ENST00000478840.1_5'UTR|UPF3B_ENST00000345865.2_Missense_Mutation_p.E286D	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	299	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						TCTTGGCTTTTTCTCTTTTGT	0.363000													11	53					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555636	155555636	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:155555636G>T	ENST00000295101.2	+	1	826	c.349G>T	c.(349-351)Gtc>Ttc	p.V117F	KCNJ3_ENST00000544049.1_Missense_Mutation_p.V117F	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	117					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	CAAAGCCCACGTCGGTAACTA	0.552000													15	43					4.7546e-09	6.25165e-09	1	1	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907748	12907748	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:12907748G>T	ENST00000317869.6	-	2	620	c.395C>A	c.(394-396)cCt>cAt	p.P132H		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						GGGAGGAGGAGGAGGTACACG	0.498000													29	50					3.73988e-18	6.21726e-18	1	1	0
FAM13C	220965	broad.mit.edu	37	10	61112086	61112086	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:61112086T>C	ENST00000373867.3	-	4	484	c.19A>G	c.(19-21)Agg>Ggg	p.R7G	FAM13C_ENST00000422313.2_Missense_Mutation_p.R90G|FAM13C_ENST00000419214.2_Missense_Mutation_p.R90G|FAM13C_ENST00000277705.6_Missense_Mutation_p.R90G|FAM13C_ENST00000373868.2_Missense_Mutation_p.R90G|FAM13C_ENST00000442566.3_Missense_Mutation_p.R90G|FAM13C_ENST00000468840.2_Missense_Mutation_p.R7G|FAM13C_ENST00000435852.2_Missense_Mutation_p.R90G	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	90										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TTGGGCTTCCTGGACTTGAAG	0.592000													20	63					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141707960	141707960	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:141707960C>A	ENST00000389484.3	-	20	3951	c.2980G>T	c.(2980-2982)Ggg>Tgg	p.G994W		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	994	LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTCCCGTCCCCACAGTCGTCA	0.448000										TSP Lung(27;0.18)			14	31					8.28177e-16	1.33018e-15	1	1	0
ANKRD26	22852	broad.mit.edu	37	10	27303608	27303608	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:27303608C>G	ENST00000376087.4	-	31	4704	c.4539G>C	c.(4537-4539)caG>caC	p.Q1513H	ANKRD26_ENST00000436985.2_Missense_Mutation_p.Q1529H|ANKRD26_ENST00000376070.3_Missense_Mutation_p.Q1070H	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1512			F -> L (in dbSNP:rs2274741).			centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TCTCTCTAAACTGCTCTAAGT	0.333000													4	13					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2775049	2775049	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:2775049C>G	ENST00000380605.2	-	14	2056	c.1992G>C	c.(1990-1992)ctG>ctC	p.L664L		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	664					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCCCTGGGGTCAGCAGACGCC	0.587000													15	45					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15928183	15928183	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:15928183C>A	ENST00000504595.1	+	3	793	c.312C>A	c.(310-312)gcC>gcA	p.A104A	FBXL7_ENST00000329673.7_Silent_p.A92A|FBXL7_ENST00000510662.1_Silent_p.A57A	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	104					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TCCGGCTCGCCTCCAGACCCC	0.687000													7	28					0.00198382	0.00210907	1	1	0
MC3R	4159	broad.mit.edu	37	20	54824002	54824002	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:54824002T>A	ENST00000243911.2	+	1	215	c.103T>A	c.(103-105)Tgt>Agt	p.C35S		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	72					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CAGCGCCTTCTGTGAGCAGGT	0.567000													40	83					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127638739	127638739	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:127638739C>G	ENST00000508053.1	-	52	6817	c.5843G>C	c.(5842-5844)tGt>tCt	p.C1948S	FBN2_ENST00000262464.4_Missense_Mutation_p.C1948S			P35556	FBN2_HUMAN	fibrillin 2	1948	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGTGTTTTTACAAGTTCCATT	0.363000													26	63					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148691761	148691761	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:148691761G>A	ENST00000296721.4	+	9	1112	c.1014G>A	c.(1012-1014)ctG>ctA	p.L338L	AFAP1L1_ENST00000515000.1_Silent_p.L338L	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	338							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGGACCTGGACAAGGTAT	0.587000													8	94					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502420	91502420	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:91502420A>T	ENST00000266718.4	-	2	791	c.337T>A	c.(337-339)Tct>Act	p.S113T	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	113					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTCAATTTAGAGAAAACTCTC	0.418000													11	31					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4935983	4935983	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:4935983A>T	ENST00000322013.3	-	1	939	c.911T>A	c.(910-912)aTc>aAc	p.I304N	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCGATCCCGGATCTGTTTGGT	0.473000													8	26					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13603505	13603505	+	Missense_Mutation	SNP	T	T	C	rs145172802		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:13603505T>C	ENST00000040738.5	-	10	5154	c.5019A>G	c.(5017-5019)atA>atG	p.I1673M		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1673							DNA binding										TTCCTTCAACTATTTCTGAGT	0.393000													60	109					0	0	1	0	0
MLST8	64223	broad.mit.edu	37	16	2256185	2256185	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:2256185C>T	ENST00000569417.1	+	2	453	c.99C>T	c.(97-99)atC>atT	p.I33I	MLST8_ENST00000561651.1_3'UTR|MLST8_ENST00000564088.1_Silent_p.I33I|MLST8_ENST00000301724.10_Silent_p.I33I|MLST8_ENST00000301725.7_Silent_p.I52I|MLST8_ENST00000565250.1_Silent_p.I33I|MLST8_ENST00000382450.4_Silent_p.I33I|MLST8_ENST00000397124.1_Silent_p.I33I	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	33					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						ACAGCGGCATCTGCACCCGGA	0.697000													25	51					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221329	102221329	+	Silent	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:102221329A>G	ENST00000227758.2	+	2	2143	c.744A>G	c.(742-744)ccA>ccG	p.P248P	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000532672.1_Silent_p.P227P|BIRC2_ENST00000530675.1_Silent_p.P199P	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	248					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		CCAACTGTCCATTTTTGGAAA	0.448000													14	52					0	0	1	0	0
DRP2	1821	broad.mit.edu	37	X	100505499	100505499	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:100505499G>T	ENST00000395209.3	+	15	2155	c.1628G>T	c.(1627-1629)cGt>cTt	p.R543L	DRP2_ENST00000538510.1_Missense_Mutation_p.R543L|DRP2_ENST00000402866.1_Missense_Mutation_p.R543L|DRP2_ENST00000541709.1_Missense_Mutation_p.R465L	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	543					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						CAGGTGCCCCGTCAGCTGGGT	0.612000													35	78					9.8876e-21	1.70341e-20	1	1	0
LTBP1	4052	broad.mit.edu	37	2	33413709	33413709	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:33413709C>A	ENST00000404816.2	+	7	1845	c.1492C>A	c.(1492-1494)Cat>Aat	p.H498N	LTBP1_ENST00000418533.2_Missense_Mutation_p.H172N|LTBP1_ENST00000402934.1_Missense_Mutation_p.H172N|LTBP1_ENST00000390003.4_Missense_Mutation_p.H172N|LTBP1_ENST00000404525.1_Missense_Mutation_p.H172N|LTBP1_ENST00000354476.3_Missense_Mutation_p.H498N|LTBP1_ENST00000407925.1_Missense_Mutation_p.H172N			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	498					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CGTCCAGATACATCAGGTTTC	0.458000													26	47					5.61819e-17	9.2514e-17	1	1	0
OR5T2	219464	broad.mit.edu	37	11	55999732	55999732	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:55999732G>T	ENST00000313264.4	-	1	1005	c.930C>A	c.(928-930)gaC>gaA	p.D310E		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					ACACTATCATGTCATGGTCCG	0.398000													23	83					1.04121e-07	1.30339e-07	1	1	0
PLP1	5354	broad.mit.edu	37	X	103041545	103041545	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:103041545G>A	ENST00000418604.1	+	4	623	c.343G>A	c.(343-345)Gca>Aca	p.A115T	PLP1_ENST00000303958.2_Missense_Mutation_p.A115T|PLP1_ENST00000361621.2_Missense_Mutation_p.A115T	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	115					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GGGCCTGAGCGCAACGGTAAC	0.582000													42	93					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287279	202287279	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:202287279C>A	ENST00000367278.3	+	18	1937	c.1848C>A	c.(1846-1848)ggC>ggA	p.G616G	LGR6_ENST00000439764.2_Silent_p.G477G|LGR6_ENST00000255432.7_Silent_p.G564G	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	616						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TTTCCTGTGGCCTTCTAGCCT	0.637000													3	47					1	1	1	1	0
CDH7	1005	broad.mit.edu	37	18	63527057	63527057	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:63527057C>G	ENST00000536984.2	+	10	2302	c.1608C>G	c.(1606-1608)aaC>aaG	p.N536K	CDH7_ENST00000397968.2_Missense_Mutation_p.N536K|CDH7_ENST00000323011.3_Missense_Mutation_p.N536K			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	536	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TGAAAGATAACAAAGGTAATG	0.363000													3	17					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	69902567	69902567	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:69902567C>A	ENST00000395889.2	-	15	1313	c.1158G>T	c.(1156-1158)aaG>aaT	p.K386N	TEX11_ENST00000344304.3_Missense_Mutation_p.K386N|TEX11_ENST00000374333.2_Missense_Mutation_p.K371N|TEX11_ENST00000374320.2_Missense_Mutation_p.K61N	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	386							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					GAAGTTCTTCCTTCCTTTGTA	0.333000													7	14					1.58986e-06	1.90346e-06	1	1	0
TCERG1	10915	broad.mit.edu	37	5	145843192	145843192	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:145843192C>T	ENST00000296702.5	+	5	1009	c.971C>T	c.(970-972)cCt>cTt	p.P324L	TCERG1_ENST00000394421.2_Missense_Mutation_p.P324L	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	324	Thr-rich.			P -> R (in Ref. 1; AAB80727).	regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTCCTGCTCCTACAGCCACA	0.493000													14	134					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74548901	74548901	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:74548901C>G	ENST00000263665.6	-	2	118	c.91G>C	c.(91-93)Gaa>Caa	p.E31Q		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	31	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTGCTGGGTTCTTTGATAAAT	0.378000													17	52					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75296160	75296160	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:75296160G>A	ENST00000339859.4	-	10	1111	c.1011C>T	c.(1009-1011)tgC>tgT	p.C337C	USP54_ENST00000497106.1_5'UTR|USP54_ENST00000428547.1_Silent_p.C187C|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000319786.7_Silent_p.C337C|USP54_ENST00000408019.1_Silent_p.C337C			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	337					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GCCCCTTGATGCATTTGGTCA	0.483000													22	85					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32635371	32635371	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:32635371C>T	ENST00000242310.4	-	1	296	c.207G>A	c.(205-207)ggG>ggA	p.G69G	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	69					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCCCCAAAGCCCCCAAGCCTG	0.537000													23	79					0	0	1	0	0
PREB	10113	broad.mit.edu	37	2	27354669	27354669	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:27354669T>C	ENST00000260643.2	-	8	1283	c.1030A>G	c.(1030-1032)Att>Gtt	p.I344V	PREB_ENST00000406567.3_Missense_Mutation_p.I286V	NM_013388.4	NP_037520.1	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding	344					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCACCACAATGCCATGGGCC	0.562000													45	128					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50339437	50339437	+	Missense_Mutation	SNP	C	C	T	rs142217351		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:50339437C>T	ENST00000394697.2	+	13	1959	c.1619C>T	c.(1618-1620)tCg>tTg	p.S540L	ADCY7_ENST00000254235.3_Missense_Mutation_p.S540L|ADCY7_ENST00000566433.2_Missense_Mutation_p.S540L|ADCY7_ENST00000538642.1_Missense_Mutation_p.S540L|ADCY7_ENST00000537579.1_Intron			P51828	ADCY7_HUMAN	adenylate cyclase 7	540					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	AAGGGGCGGTCGGAGGATGAC	0.597000													19	172					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37187382	37187382	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:37187382C>A	ENST00000338564.5	-	12	1542	c.1096G>T	c.(1096-1098)Ggt>Tgt	p.G366C	MEIS2_ENST00000444725.1_Missense_Mutation_p.G366C|MEIS2_ENST00000340545.5_Missense_Mutation_p.G353C|MEIS2_ENST00000397620.2_Missense_Mutation_p.G278C|MEIS2_ENST00000219869.9_Missense_Mutation_p.G227C|MEIS2_ENST00000561208.1_Missense_Mutation_p.G373C|MEIS2_ENST00000382766.2_Missense_Mutation_p.G366C|MEIS2_ENST00000559561.1_Missense_Mutation_p.G366C|MEIS2_ENST00000559408.1_5'UTR|MEIS2_ENST00000559085.1_Missense_Mutation_p.G360C|MEIS2_ENST00000557796.2_Missense_Mutation_p.G353C|MEIS2_ENST00000397624.3_Missense_Mutation_p.G278C|MEIS2_ENST00000424352.2_Missense_Mutation_p.G373C	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	373					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TGTTGCTGACCATCCAACACA	0.572000													32	93					2.51541e-25	4.48138e-25	1	1	0
DHX29	54505	broad.mit.edu	37	5	54581634	54581634	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:54581634C>A	ENST00000251636.5	-	9	1270	c.1122G>T	c.(1120-1122)tgG>tgT	p.W374C	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	374							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATTTTCCAGTCCAACTTCGAG	0.348000													5	22					0.0215528	0.0220599	1	1	0
SON	6651	broad.mit.edu	37	21	34927181	34927181	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:34927181G>T	ENST00000356577.4	+	3	6119	c.5644G>T	c.(5644-5646)Gga>Tga	p.G1882*	SON_ENST00000300278.4_Nonsense_Mutation_p.G1882*|SON_ENST00000381679.4_Nonsense_Mutation_p.G1882*|SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Nonsense_Mutation_p.G1882*	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1882					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						AAAGTCTAGAGGAAGAAGATC	0.443000													9	21					0.0692343	0.0704489	1	1	0
ABCG8	64241	broad.mit.edu	37	2	44102327	44102327	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:44102327T>C	ENST00000272286.2	+	11	1621	c.1531T>C	c.(1531-1533)Tac>Cac	p.Y511H		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	511	ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CATCATCATCTACGGGATGCC	0.562000													32	66					0	0	1	0	0
ZRSR2	8233	broad.mit.edu	37	X	15840940	15840940	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:15840940G>T	ENST00000307771.7	+	11	1048	c.1024G>T	c.(1024-1026)Gct>Tct	p.A342S		NM_005089.3	NP_005080.1	Q15696	U2AFM_HUMAN	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2	342					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(38)|kidney(1)|large_intestine(2)|ovary(2)	48	Hepatocellular(33;0.183)					ATTCTGGGAAGCTAATAGAGA	0.463000			"""F, S, Mis"""		"""MDS, CLL"""								18	48					6.49762e-13	9.69074e-13	1	1	0
AGL	178	broad.mit.edu	37	1	100316648	100316648	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:100316648A>T	ENST00000294724.4	+	2	528	c.50A>T	c.(49-51)aAa>aTa	p.K17I	AGL_ENST00000361302.3_5'UTR|AGL_ENST00000370163.3_Missense_Mutation_p.K17I|AGL_ENST00000361915.3_Missense_Mutation_p.K17I|AGL_ENST00000370165.3_Missense_Mutation_p.K17I	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	17					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GAAATGGAGAAACTGGAAAAG	0.358000													32	52					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870090	4870090	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:4870090C>T	ENST00000322101.2	-	1	424	c.349G>A	c.(349-351)Gtc>Atc	p.V117I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACTCCATGACAGAAAAGACA	0.557000													31	66					0	0	1	0	0
MOB3B	79817	broad.mit.edu	37	9	27359199	27359199	+	Nonsense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:27359199T>A	ENST00000262244.5	-	3	878	c.454A>T	c.(454-456)Aag>Tag	p.K152*	MOB3B_ENST00000603061.1_5'UTR	NM_024761.4	NP_079037.3	Q86TA1	MOL2B_HUMAN	MOB kinase activator 3B	152				K -> M (in Ref. 5; AAH33027).			metal ion binding|protein binding										AGGATCTTCTTGCAGATCTGA	0.473000													48	126					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93593219	93593219	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:93593219G>T	ENST00000394236.3	-	15	2217	c.1901C>A	c.(1900-1902)gCc>gAc	p.A634D	PROS1_ENST00000407433.1_Missense_Mutation_p.A503D	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	634	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ATTATAAAAGGCATTCACTGG	0.358000													6	16					0.00307968	0.00325424	1	1	0
WIPF1	7456	broad.mit.edu	37	2	175436932	175436932	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:175436932G>C	ENST00000392547.2	-	5	700	c.601C>G	c.(601-603)Cgg>Ggg	p.R201G	WIPF1_ENST00000409415.3_Missense_Mutation_p.R201G|WIPF1_ENST00000359761.3_Missense_Mutation_p.R201G|WIPF1_ENST00000272746.5_Missense_Mutation_p.R201G|WIPF1_ENST00000409891.1_Missense_Mutation_p.R201G|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000392546.2_Missense_Mutation_p.R201G|AC018890.6_ENST00000412835.1_RNA	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	201					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						GGGGACCCCCGGTTGTGCGGA	0.657000													36	135					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22969346	22969346	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr15:22969346A>T	ENST00000313077.7	+	22	2697	c.2572A>T	c.(2572-2574)Aac>Tac	p.N858Y	CYFIP1_ENST00000560848.1_Missense_Mutation_p.N858Y|CYFIP1_ENST00000435939.2_Missense_Mutation_p.N427Y	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	858					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CTACTGCTACAACGGCTCTAC	0.637000													27	65					0	0	1	0	0
GPM6B	2824	broad.mit.edu	37	X	13825877	13825877	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:13825877C>A	ENST00000316715.4	-	2	510	c.73G>T	c.(73-75)Gct>Tct	p.A25S	GPM6B_ENST00000398361.3_Intron|GPM6B_ENST00000493677.1_5'UTR|GPM6B_ENST00000454189.2_Intron|GPM6B_ENST00000355135.2_Missense_Mutation_p.A25S|GPM6B_ENST00000356942.5_Intron	NM_001001995.1	NP_001001995.1	Q13491	GPM6B_HUMAN	glycoprotein M6B	20					cell differentiation|nervous system development	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|pancreas(1)	6						TCCATTTCAGCTCTGCTGTTC	0.473000													40	64					1.41504e-22	2.4704e-22	1	1	0
OR52A1	23538	broad.mit.edu	37	11	5173074	5173074	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:5173074C>T	ENST00000380367.1	-	2	943	c.526G>A	c.(526-528)Gtc>Atc	p.V176I	OR52A1_ENST00000328942.1_Missense_Mutation_p.V176I			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	176					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGAGATGACTGTTGTGTGA	0.433000													25	57					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104507	142104507	+	RNA	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:142104507G>T	ENST00000390379.1	-	0	46																											GGACCCACCTGCCCACAGGAG	0.602000													20	50					1.22574e-08	1.57984e-08	1	1	0
NUTM2F	54754	broad.mit.edu	37	9	97082809	97082809	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:97082809C>A	ENST00000335456.7	-	5	1069	c.1049G>T	c.(1048-1050)aGg>aTg	p.R350M	NUTM2F_ENST00000253262.4_Missense_Mutation_p.R350M|NUTM2F_ENST00000341207.4_Missense_Mutation_p.R350M					NUT family member 2F																		CTCCGCTGGCCTCTGGGGCCT	0.701000													11	21					2.48551e-13	3.76068e-13	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66467428	66467428	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:66467428C>A	ENST00000273854.3	-	3	1441	c.841G>T	c.(841-843)Gag>Tag	p.E281*	EPHA5_ENST00000354839.4_Nonsense_Mutation_p.E281*|EPHA5_ENST00000432638.2_Nonsense_Mutation_p.E281*|EPHA5_ENST00000511294.1_Nonsense_Mutation_p.E281*	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	281	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ACCAGCCACTCCCCTTCGGCG	0.532000										TSP Lung(17;0.13)			21	65					7.88262e-20	1.3403e-19	1	1	0
EYS	346007	broad.mit.edu	37	6	66115234	66115234	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:66115234G>T	ENST00000503581.1	-	6	1426	c.889C>A	c.(889-891)Cct>Act	p.P297T	EYS_ENST00000342421.5_Missense_Mutation_p.P297T|EYS_ENST00000393380.2_Missense_Mutation_p.P297T|EYS_ENST00000370616.2_Missense_Mutation_p.P297T|EYS_ENST00000370618.3_Missense_Mutation_p.P297T|EYS_ENST00000370621.3_Missense_Mutation_p.P297T	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	297					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GAAACACAAGGTTTTGCTGAC	0.368000													30	45					4.11147e-13	6.16721e-13	1	1	0
CUX2	23316	broad.mit.edu	37	12	111748436	111748436	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:111748436C>T	ENST00000261726.6	+	15	2004	c.1850C>T	c.(1849-1851)tCg>tTg	p.S617L		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	617						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CAGTTCCTGTCGGATGAGCAG	0.647000													10	38					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129901458	129901458	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:129901458C>T	ENST00000368654.3	-	13	9021	c.8646G>A	c.(8644-8646)acG>acA	p.T2882T	MKI67_ENST00000368653.3_Silent_p.T2522T	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2882	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TAAATGCTTTCGTGCCTTTGC	0.542000													9	104					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5146296	5146296	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:5146296C>A	ENST00000274181.7	+	3	367	c.229C>A	c.(229-231)Cat>Aat	p.H77N	CTD-2297D10.1_ENST00000514848.1_RNA|ADAMTS16_ENST00000511368.1_Missense_Mutation_p.H77N	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	77					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TTACGTGTCCCATGAAATCAT	0.532000													18	77					2.94398e-08	3.76657e-08	1	1	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226960	168226960	+	RNA	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:168226960C>A	ENST00000359760.5	-	0	429					NR_027906.1																						ACCACCCATCCGAACCGAACC	0.692000													87	132					3.85665e-30	6.96599e-30	1	1	0
CYP4F2	8529	broad.mit.edu	37	19	15990587	15990587	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:15990587C>A	ENST00000221700.5	-	10	1331	c.1236G>T	c.(1234-1236)cgG>cgT	p.R412R	CYP4F2_ENST00000592328.1_Silent_p.R412R	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	412					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TGGGGATGACCCGGCCGTCTG	0.632000													28	82					6.90743e-12	9.98802e-12	1	1	0
SEC31A	22872	broad.mit.edu	37	4	83748591	83748591	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:83748591G>T	ENST00000432794.1	-	25	3424	c.3261C>A	c.(3259-3261)ggC>ggA	p.G1087G	SEC31A_ENST00000500777.2_Silent_p.G921G|SEC31A_ENST00000508502.1_Silent_p.G1059G|SEC31A_ENST00000509142.1_Silent_p.G960G|SEC31A_ENST00000348405.4_Silent_p.G1035G|SEC31A_ENST00000513858.1_Silent_p.G921G|SEC31A_ENST00000326950.5_Silent_p.G1035G|SEC31A_ENST00000395310.2_Silent_p.G1074G|SEC31A_ENST00000355196.2_Silent_p.G1074G|SEC31A_ENST00000505472.1_Silent_p.G1105G|SEC31A_ENST00000264405.5_Silent_p.G823G|SEC31A_ENST00000311785.7_Silent_p.G960G|SEC31A_ENST00000443462.2_Silent_p.G1054G|SEC31A_ENST00000505984.1_Silent_p.G1020G|SEC31A_ENST00000448323.1_Silent_p.G1074G			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	1074	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				ATGGTGGCATGCCTGTTTGAC	0.502000													39	84					5.71845e-15	8.83145e-15	1	1	0
MUC17	140453	broad.mit.edu	37	7	100683730	100683730	+	Silent	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:100683730T>C	ENST00000306151.4	+	3	9097	c.9033T>C	c.(9031-9033)ccT>ccC	p.P3011P		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3011	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAAGAACTCCTGCTGACACCA	0.502000													157	307					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139160884	139160884	+	Silent	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:139160884T>C	ENST00000395297.1	-	14	3497	c.3327A>G	c.(3325-3327)gaA>gaG	p.E1109E		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1109										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACAGAAATCCTTCAATCTTCA	0.363000										HNSCC(54;0.14)			25	14					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125885926	125885926	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:125885926G>C	ENST00000409134.3	-	15	1596	c.1377C>G	c.(1375-1377)atC>atG	p.I459M	ALDH7A1_ENST00000447989.2_Missense_Mutation_p.I422M|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.I395M	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	459					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	CTTTGGTAAAGATGCTACTTG	0.358000													9	27					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64216808	64216808	+	Nonsense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:64216808A>T	ENST00000205948.6	-	5	505	c.468T>A	c.(466-468)taT>taA	p.Y156*		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	156	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CTGATGGCTTATAAACACGAA	0.403000													23	65					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39530024	39530024	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr22:39530024G>A	ENST00000216133.5	-	6	833	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	CBX7_ENST00000475962.1_Intron|CBX7_ENST00000401405.3_Missense_Mutation_p.P117S	NM_175709.3	NP_783640.1	O95931	CBX7_HUMAN	chromobox homolog 7	210					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	Melanoma(58;0.04)					GGTGTCCAGGGAGGGGGCCCC	0.657000													5	98					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71350845	71350845	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:71350845G>A	ENST00000545866.1	-	1	913	c.546C>T	c.(544-546)ccC>ccT	p.P182P	RGAG4_ENST00000479991.1_Silent_p.P182P|NHSL2_ENST00000540800.1_Intron			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	182										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					CGGCGCCCCCGGGGAAATGAA	0.582000													7	32					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38948829	38948829	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:38948829C>A	ENST00000355481.4	+	18	2195	c.2064C>A	c.(2062-2064)acC>acA	p.T688T	RYR1_ENST00000360985.3_Silent_p.T688T|RYR1_ENST00000359596.3_Silent_p.T688T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	688	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.T688T(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGCCCTCACCGAGGGCTACA	0.627000													19	66					1.01871e-10	1.40308e-10	1	1	0
ZFP92	139735	broad.mit.edu	37	X	152686378	152686378	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:152686378G>T	ENST00000338647.5	+	4	544	c.543G>T	c.(541-543)gcG>gcT	p.A181A		NM_001136273.1	NP_001129745.1	A6NM28	ZFP92_HUMAN	ZFP92 zinc finger protein	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(4)	6						AGCCTTACGCGTGCCCCGAGT	0.652000													5	8					0.014758	0.0152548	1	1	0
NXF5	55998	broad.mit.edu	37	X	101092551	101092551	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:101092551T>A	ENST00000537026.1	-	15	1354	c.995A>T	c.(994-996)cAg>cTg	p.Q332L	NXF5_ENST00000473265.2_Missense_Mutation_p.Q332L|NXF5_ENST00000361708.2_Missense_Mutation_p.Q332L	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	332	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						GAAGTCATGCTGAGTTTCAGG	0.542000													53	110					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24538031	24538031	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:24538031C>A	ENST00000342740.5	+	38	3992	c.3838C>A	c.(3838-3840)Cca>Aca	p.P1280T	LRRC16B_ENST00000334420.7_Missense_Mutation_p.P333T	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1280										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCCTCCCAAGCCAGTGGCTGT	0.642000													12	13					1.05317e-09	1.41325e-09	1	1	0
PPP1R26	9858	broad.mit.edu	37	9	138376987	138376987	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:138376987G>T	ENST00000356818.2	+	4	1180	c.631G>T	c.(631-633)Gcc>Tcc	p.A211S	PPP1R26_ENST00000401470.3_Missense_Mutation_p.A211S|PPP1R26_ENST00000604351.1_Missense_Mutation_p.A211S|PPP1R26_ENST00000605286.1_Missense_Mutation_p.A211S|PPP1R26_ENST00000605660.1_Missense_Mutation_p.A211S|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	211						nucleolus	protein binding										CCAGGGCTCCGCCTCCCCGGT	0.592000													34	76					1.96642e-18	3.28997e-18	1	1	0
GLI3	2737	broad.mit.edu	37	7	42005519	42005519	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:42005519C>A	ENST00000395925.3	-	15	3236	c.3152G>T	c.(3151-3153)cGg>cTg	p.R1051L	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1051					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GCCCTCGGGCCGCGTGTAATT	0.662000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				19	43					6.21321e-17	1.0199e-16	1	1	0
NPR3	4883	broad.mit.edu	37	5	32739072	32739072	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:32739072T>C	ENST00000265074.8	+	3	1338	c.995T>C	c.(994-996)tTt>tCt	p.F332S	NPR3_ENST00000415685.2_Missense_Mutation_p.F116S|NPR3_ENST00000415167.2_Missense_Mutation_p.F332S|NPR3_ENST00000434067.2_Missense_Mutation_p.F116S	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	332					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	AAACCTGAGTTTGAGAAGTTT	0.453000													20	68					0	0	1	0	0
MID1	4281	broad.mit.edu	37	X	10417750	10417750	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:10417750G>T	ENST00000317552.4	-	10	2062	c.1662C>A	c.(1660-1662)gcC>gcA	p.A554A	MID1_ENST00000479925.1_5'UTR|MID1_ENST00000453318.2_Silent_p.A554A|MID1_ENST00000380780.1_Silent_p.A554A|MID1_ENST00000380782.2_Intron|MID1_ENST00000380785.1_Silent_p.A554A|MID1_ENST00000380787.1_Silent_p.A554A|MID1_ENST00000380779.1_Silent_p.A554A	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	554	B30.2/SPRY.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						CAAGACCAATGGCATACCTGC	0.478000													10	26					0.000673444	0.000730848	1	1	0
HKR1	284459	broad.mit.edu	37	19	37854121	37854121	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:37854121G>T	ENST00000591471.1	+	9	2246	c.605G>T	c.(604-606)gGg>gTg	p.G202V	HKR1_ENST00000324411.4_Missense_Mutation_p.G475V|HKR1_ENST00000589392.1_Missense_Mutation_p.G457V|HKR1_ENST00000541583.2_Missense_Mutation_p.G414V|HKR1_ENST00000544914.1_Missense_Mutation_p.G202V|HKR1_ENST00000591134.1_Intron|HKR1_ENST00000392153.3_Missense_Mutation_p.G456V			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	475					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGGAGTGCGGGCAGTGCTTT	0.512000													22	62					5.45024e-15	8.44221e-15	1	1	0
CABS1	85438	broad.mit.edu	37	4	71201476	71201476	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:71201476C>A	ENST00000273936.4	+	1	779	c.720C>A	c.(718-720)acC>acA	p.T240T		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	240						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGAAAATAACCGAAATTGACC	0.418000													7	37					5.18039e-06	6.11802e-06	1	1	0
SI	6476	broad.mit.edu	37	3	164777757	164777757	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:164777757C>A	ENST00000264382.3	-	10	1141	c.1079G>T	c.(1078-1080)tGg>tTg	p.W360L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	360	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTTATAATTCCAGCGACTTAG	0.373000										HNSCC(35;0.089)			37	98					3.78316e-11	5.26616e-11	1	1	0
WDR49	151790	broad.mit.edu	37	3	167322098	167322098	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:167322098T>A	ENST00000308378.3	-	2	399	c.94A>T	c.(94-96)Aat>Tat	p.N32Y	WDR49_ENST00000453925.2_Missense_Mutation_p.N85Y|WDR49_ENST00000479765.1_Missense_Mutation_p.N373Y	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	32										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CCAATTAAATTGAGCCGAGAG	0.388000													8	27					0	0	1	0	0
TAOK3	51347	broad.mit.edu	37	12	118610414	118610414	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:118610414A>G	ENST00000392533.3	-	17	2237	c.1747T>C	c.(1747-1749)Tcc>Ccc	p.S583P	TAOK3_ENST00000419821.2_Missense_Mutation_p.S583P|TAOK3_ENST00000537952.1_Missense_Mutation_p.S123P	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	583					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTATGTTTGGAGATCCGCTCT	0.433000													39	118					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808217	8808217	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:8808217T>A	ENST00000324436.3	-	1	955	c.835A>T	c.(835-837)Act>Tct	p.T279S		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	279						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						AGCTTCAGAGTCCGCTTGTAC	0.632000													15	46					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15850237	15850237	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:15850237C>A	ENST00000338282.6	-	14	1816	c.1710G>T	c.(1708-1710)aaG>aaT	p.K570N	MYH11_ENST00000452625.2_Missense_Mutation_p.K577N|MYH11_ENST00000396324.3_Missense_Mutation_p.K577N|MYH11_ENST00000300036.5_Missense_Mutation_p.K570N|MYH11_ENST00000576790.1_Missense_Mutation_p.K570N	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	570	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CAGTCTTGTCCTTGAGCTGCT	0.592000			T	CBFB	AML						OREG0023636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	35					4.3838e-07	5.32173e-07	1	1	0
MDN1	23195	broad.mit.edu	37	6	90365644	90365644	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:90365644A>T	ENST00000369393.3	-	92	15444	c.15329T>A	c.(15328-15330)aTg>aAg	p.M5110K	MDN1_ENST00000428876.1_Missense_Mutation_p.M5110K			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	5110					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGATCACCCATGGAACGTTC	0.532000													16	19					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55523560	55523560	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:55523560G>T	ENST00000305377.5	+	1	96	c.8G>T	c.(7-9)gGa>gTa	p.G3V		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						GTAATGCTAGGATCCAAACCA	0.338000													12	46					0.00010058	0.000112667	1	1	0
TDRD6	221400	broad.mit.edu	37	6	46657549	46657549	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:46657549G>T	ENST00000544460.1	+	1	1938	c.1684G>T	c.(1684-1686)Gac>Tac	p.D562Y	TDRD6_ENST00000316081.6_Missense_Mutation_p.D562Y	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	562	Tudor 3.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			CAAATTGGATGACAAGAGTGT	0.428000													32	121					1.07637e-12	1.60075e-12	1	1	0
ESPNL	339768	broad.mit.edu	37	2	239040110	239040110	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:239040110T>A	ENST00000343063.3	+	9	3018	c.2755T>A	c.(2755-2757)Ttc>Atc	p.F919I	ESPNL_ENST00000477241.1_3'UTR|ESPNL_ENST00000409169.1_Missense_Mutation_p.F875I|ESPNL_ENST00000409506.1_Missense_Mutation_p.F551I	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	919										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GACCGACGGCTTCGAGGACAT	0.711000													8	12					0	0	1	0	0
PAGE2	203569	broad.mit.edu	37	X	55116965	55116965	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:55116965G>T	ENST00000374968.4	+	3	219	c.115G>T	c.(115-117)Gaa>Taa	p.E39*	PAGE2_ENST00000374965.1_Nonsense_Mutation_p.E39*	NM_207339.2	NP_997222.1			P antigen family, member 2 (prostate associated)											endometrium(1)|large_intestine(2)|lung(1)|ovary(2)	6						AAAACGTCAAGAAGAGGAACC	0.413000													10	15					0.00829132	0.00865614	1	1	0
MIB1	57534	broad.mit.edu	37	18	19353597	19353597	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:19353597C>T	ENST00000261537.6	+	4	808	c.544C>T	c.(544-546)Cag>Tag	p.Q182*	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	182	MIB/HERC2 2.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			AACAGAAATCCAGGACTGGAG	0.378000													14	38					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70465190	70465190	+	Splice_Site	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:70465190C>G	ENST00000373998.1	-	18	3667	c.2971_splice	c.e18+1	p.K990_splice	ZMYM3_ENST00000373984.3_Splice_Site_p.K1004_splice|ZMYM3_ENST00000353904.2_Splice_Site_p.K1002_splice|ZMYM3_ENST00000373988.1_Splice_Site_p.K1004_splice|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000314425.5_Splice_Site_p.K1002_splice	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1002					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					CTTACTCACTCTTAGGGAAGT	0.527000													20	45					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18740270	18740270	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:18740270G>T	ENST00000513874.1	-	8	841	c.702C>A	c.(700-702)atC>atA	p.I234I	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	234	Ig-like 2.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TCAGAATCCGGATGGCCTGAG	0.458000													20	52					1.10513e-12	1.63422e-12	1	1	0
VANGL1	81839	broad.mit.edu	37	1	116202368	116202368	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:116202368G>A	ENST00000355485.2	+	3	449	c.178G>A	c.(178-180)Gat>Aat	p.D60N	VANGL1_ENST00000369510.3_Missense_Mutation_p.D60N|VANGL1_ENST00000369509.1_Missense_Mutation_p.D60N|VANGL1_ENST00000310260.3_Missense_Mutation_p.D60N	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	60					multicellular organismal development	integral to membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTTGGGAAATGATTCTACTCG	0.488000													10	72					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27346303	27346303	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:27346303G>A	ENST00000429845.2	-	13	1325	c.963C>T	c.(961-963)gaC>gaT	p.D321D	NEK10_ENST00000341435.5_Silent_p.D321D			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	321							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGGTCTCAGGGTCCTCACAAA	0.507000													11	30					0	0	1	0	0
SLC6A8	6535	broad.mit.edu	37	X	152957557	152957557	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:152957557G>T	ENST00000253122.5	+	4	1248	c.772G>T	c.(772-774)Gga>Tga	p.G258*	SLC6A8_ENST00000430077.2_Nonsense_Mutation_p.G143*	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	258					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	CAAATCCACGGGAAAGGTACC	0.627000													3	12					1.024e-07	1.28492e-07	1	1	0
OR10W1	81341	broad.mit.edu	37	11	58034615	58034615	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:58034615A>G	ENST00000395079.2	-	1	1117	c.716T>C	c.(715-717)gTg>gCg	p.V239A		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CTGCAGCAGCACCACAGTGAG	0.582000													31	79					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102187852	102187852	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:102187852G>C	ENST00000306176.1	+	8	954	c.854G>C	c.(853-855)aGc>aCc	p.S285T	ZPLD1_ENST00000466937.1_Missense_Mutation_p.S269T|ZPLD1_ENST00000491959.1_Missense_Mutation_p.S269T	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	269	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						AATGGCCGAAGCCAGCGGGGC	0.478000													17	27					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88040885	88040885	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:88040885C>T	ENST00000319595.4	+	1	1040	c.986C>T	c.(985-987)tCc>tTc	p.S329F		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	329					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GAAGAAATGTCCAATTTTTTG	0.323000													3	25					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51226934	51226934	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:51226934C>G	ENST00000245441.5	-	17	2230	c.2040G>C	c.(2038-2040)caG>caC	p.Q680H	NIN_ENST00000530997.2_Missense_Mutation_p.Q680H|NIN_ENST00000382043.4_Missense_Mutation_p.Q680H|NIN_ENST00000453196.1_Missense_Mutation_p.Q680H|NIN_ENST00000389868.3_Missense_Mutation_p.Q680H|NIN_ENST00000324330.9_Missense_Mutation_p.Q680H|NIN_ENST00000382041.3_Missense_Mutation_p.Q680H	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	680					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CTGCTTGCCCCTGAAGTTCAG	0.458000			T	PDGFRB	MPD								31	55					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46289820	46289820	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:46289820G>A	ENST00000270223.6	-	3	979	c.934C>T	c.(934-936)Cac>Tac	p.H312Y	DMWD_ENST00000377735.3_Missense_Mutation_p.H312Y	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	312					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		GAGTCGAAGTGGAAGACGCGC	0.662000													14	35					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151962165	151962165	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:151962165G>T	ENST00000355193.2	-	8	1360	c.1142C>A	c.(1141-1143)gCa>gAa	p.A381E	KMT2C_ENST00000262189.6_Missense_Mutation_p.A381E					lysine (K)-specific methyltransferase 2C																		TTGCCAACCTGCACGTTTTAA	0.438000													16	414					7.41877e-09	9.63333e-09	1	1	0
TEX11	56159	broad.mit.edu	37	X	70073099	70073099	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:70073099G>T	ENST00000395889.2	-	7	604	c.450_splice	c.e7+1	p.A150_splice	TEX11_ENST00000344304.3_Splice_Site_p.A150_splice|TEX11_ENST00000374333.2_Splice_Site_p.A135_splice	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	150							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					GTAACTTACGGCCACAGCAGC	0.353000													7	18					0.0581538	0.0592896	1	1	0
STAG1	10274	broad.mit.edu	37	3	136117607	136117607	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:136117607T>C	ENST00000383202.2	-	22	2517	c.2261A>G	c.(2260-2262)gAt>gGt	p.D754G	STAG1_ENST00000434713.2_Missense_Mutation_p.D528G|STAG1_ENST00000236698.5_Missense_Mutation_p.D754G|STAG1_ENST00000536929.1_Missense_Mutation_p.D338G	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	754					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						AGGAGAGCCATCAGTAATTTT	0.313000													16	18					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91229853	91229853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:91229853G>T	ENST00000509176.1	+	2	706	c.418G>T	c.(418-420)Gag>Tag	p.E140*	CCSER1_ENST00000432775.2_Nonsense_Mutation_p.E140*|CCSER1_ENST00000333691.8_Nonsense_Mutation_p.E140*	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		AAGGGAAAAAGAGCACTCAAC	0.368000													3	11					1	1	1	1	0
MED13L	23389	broad.mit.edu	37	12	116534519	116534519	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:116534519C>A	ENST00000281928.3	-	4	640	c.434G>T	c.(433-435)tGg>tTg	p.W145L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	145					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCGGACAAACCATTTCCCAAT	0.388000													14	44					9.16793e-09	1.18751e-08	1	1	0
TRIM29	23650	broad.mit.edu	37	11	119998221	119998221	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:119998221C>A	ENST00000341846.5	-	3	1378	c.957G>T	c.(955-957)cgG>cgT	p.R319R	TRIM29_ENST00000541857.1_Silent_p.R52R|TRIM29_ENST00000529044.1_Silent_p.R58R	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	319					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TCTCCAGGTCCCGCACCAGGT	0.567000													16	55					4.7546e-09	6.25165e-09	1	1	0
UAP1L1	91373	broad.mit.edu	37	9	139973038	139973038	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:139973038C>A	ENST00000409858.3	+	3	611	c.579C>A	c.(577-579)aaC>aaA	p.N193K	UAP1L1_ENST00000476184.1_3'UTR|UAP1L1_ENST00000360271.3_Missense_Mutation_p.N70K	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	193							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		ACCCCGCCAACGTGGTCATGT	0.607000													8	50					1.26484e-09	1.68862e-09	1	1	0
USP6NL	9712	broad.mit.edu	37	10	11504481	11504481	+	Missense_Mutation	SNP	T	T	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:11504481T>G	ENST00000379237.1	-	15	2840	c.2446A>C	c.(2446-2448)Aat>Cat	p.N816H	USP6NL_ENST00000277575.5_Missense_Mutation_p.N833H	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	816						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						CCGTCCCGATTCCTGTAGTGG	0.507000													18	31					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267135	107267135	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:107267135A>T	ENST00000334726.2	+	1	681	c.592A>T	c.(592-594)Atc>Ttc	p.I198F		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGTGCAGTTAATCATGCTGGT	0.438000													60	116					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27473778	27473778	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:27473778C>A	ENST00000356183.4	-	36	5969	c.5954G>T	c.(5953-5955)cGg>cTg	p.R1985L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R1960L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1985						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						ACGCCACGGCCGGCCGATGAA	0.612000													7	26					0.000157383	0.000175169	1	1	0
SELRC1	65260	broad.mit.edu	37	1	53153487	53153487	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:53153487C>T	ENST00000371538.3	-	3	640	c.601G>A	c.(601-603)Gat>Aat	p.D201N	SELRC1_ENST00000486918.1_5'UTR	NM_023077.2	NP_075565.2	Q96BR5	SELR1_HUMAN	Sel1 repeat containing 1	201							binding			breast(1)|lung(3)|prostate(1)|urinary_tract(1)	6						TCATCCTTATCAACACCATCC	0.507000													10	63					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568867	55568867	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:55568867G>T	ENST00000395445.1	-	36	5337	c.4943C>A	c.(4942-4944)aCa>aAa	p.T1648K	PCDH15_ENST00000395440.1_Missense_Mutation_p.T582K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.T844K|PCDH15_ENST00000395442.1_Missense_Mutation_p.T513K|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCTGACTCTGTGGATTCCGA	0.488000										HNSCC(58;0.16)			13	27					1.61879e-10	2.21787e-10	1	1	0
COL20A1	57642	broad.mit.edu	37	20	61950474	61950474	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:61950474G>T	ENST00000422202.1	+	21	2817	c.2749G>T	c.(2749-2751)Gag>Tag	p.E917*	COL20A1_ENST00000358894.6_Nonsense_Mutation_p.E910*|COL20A1_ENST00000435874.1_Nonsense_Mutation_p.E917*|COL20A1_ENST00000326996.6_Nonsense_Mutation_p.E910*			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	910	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CCTACTTCCCGAGACACCCCG	0.657000													21	45					3.6726e-16	5.93529e-16	1	1	0
ZKSCAN7	55888	broad.mit.edu	37	3	44598651	44598651	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:44598651C>T	ENST00000273320.3	+	2	541	c.112C>T	c.(112-114)Cag>Tag	p.Q38*	ZKSCAN7_ENST00000426540.1_Nonsense_Mutation_p.Q38*|ZKSCAN7_ENST00000431636.1_Nonsense_Mutation_p.Q38*|ZKSCAN7_ENST00000341840.3_Nonsense_Mutation_p.Q38*	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		GACCTGGGGGCAGGGCAGCAG	0.572000													14	33					0	0	1	0	0
HSD17B10	3028	broad.mit.edu	37	X	53459013	53459013	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:53459013C>A	ENST00000168216.6	-	4	436	c.409G>T	c.(409-411)Ggc>Tgc	p.G137C	HSD17B10_ENST00000375304.5_Missense_Mutation_p.G137C|HSD17B10_ENST00000495986.1_5'UTR|HSD17B10_ENST00000375298.4_Missense_Mutation_p.G137C	NM_001037811.2|NM_004493.2	NP_001032900.1|NP_004484.1	Q99714	HCD2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 10	137					branched chain family amino acid catabolic process|lipid metabolic process|tRNA processing	mitochondrial matrix|plasma membrane	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|3-hydroxyacyl-CoA dehydrogenase activity|cholate 7-alpha-dehydrogenase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|skin(1)	8					NADH(DB00157)	TCATTCTGGCCCATCTCACCA	0.562000													25	54					1.10923e-09	1.48466e-09	1	1	0
VMA21	203547	broad.mit.edu	37	X	150572114	150572114	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:150572114C>T	ENST00000330374.6	+	2	170	c.65C>T	c.(64-66)tCa>tTa	p.S22L	VMA21_ENST00000477649.1_3'UTR|VMA21_ENST00000370361.1_Missense_Mutation_p.S77L	NM_001017980.3	NP_001017980.1	Q3ZAQ7	VMA21_HUMAN	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)	22					vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	7						AATGAAAGCTCATTAGCATCT	0.353000													24	85					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033144	41033144	+	Missense_Mutation	SNP	G	G	A	rs140140179		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr21:41033144G>A	ENST00000380620.3	+	5	1250	c.658G>A	c.(658-660)Gtg>Atg	p.V220M	B3GALT5_ENST00000398714.2_Missense_Mutation_p.V220M|B3GALT5_ENST00000380618.1_Missense_Mutation_p.V220M|B3GALT5_ENST00000343118.4_Missense_Mutation_p.V220M|AF064860.5_ENST00000416555.1_RNA			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	220					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				CACCGGCTACGTGTTTTCTGG	0.522000													26	57					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91196420	91196420	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:91196420C>A	ENST00000357056.2	-	5	818	c.698_splice	c.e5+1	p.G233_splice	TTC7B_ENST00000328459.6_Splice_Site_p.G233_splice			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	233							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				ATGGCTTACCCATTTTTGAAA	0.388000													24	41					7.53681e-25	1.33363e-24	1	1	0
OR2T33	391195	broad.mit.edu	37	1	248436337	248436337	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:248436337G>T	ENST00000318021.2	-	1	801	c.780C>A	c.(778-780)ccC>ccA	p.P260P		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P260P(1)		NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TATGGGATTTGGGTCTCATAT	0.478000													6	106					1.64293e-13	2.51499e-13	1	1	0
FGD1	2245	broad.mit.edu	37	X	54496629	54496629	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:54496629G>T	ENST00000375135.3	-	4	1654	c.921C>A	c.(919-921)agC>agA	p.S307R		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	307	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AGAGGCTGTGGCTGGGGGGCC	0.657000													13	10					1.49906e-05	1.73505e-05	1	1	0
KCNB1	3745	broad.mit.edu	37	20	47989689	47989689	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:47989689G>T	ENST00000371741.4	-	2	2574	c.2408C>A	c.(2407-2409)cCc>cAc	p.P803H		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	803					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGGGGAGGTGGGTAAAGGGGA	0.522000													57	130					2.40265e-35	4.47922e-35	1	1	0
SBNO1	55206	broad.mit.edu	37	12	123780484	123780484	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:123780484G>A	ENST00000420886.2	-	31	4152	c.4153C>T	c.(4153-4155)Cag>Tag	p.Q1385*	SBNO1_ENST00000602750.1_Nonsense_Mutation_p.Q1384*|SBNO1_ENST00000267176.4_Nonsense_Mutation_p.Q1384*|SBNO1_ENST00000602398.1_Nonsense_Mutation_p.Q1385*	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1385							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GTGATGCTCTGAGGGTGATGC	0.443000													31	228					0	0	1	0	0
SLC37A4	2542	broad.mit.edu	37	11	118898449	118898449	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:118898449G>C	ENST00000545985.1	-	5	1271	c.515C>G	c.(514-516)tCt>tGt	p.S172C	SLC37A4_ENST00000525102.1_5'UTR|SLC37A4_ENST00000357590.5_Missense_Mutation_p.S172C|SLC37A4_ENST00000538950.1_Missense_Mutation_p.S99C|SLC37A4_ENST00000330775.7_Missense_Mutation_p.S172C	NM_001164277.1|NM_001467.5	NP_001157749.1|NP_001458.1	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 4	172					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	6	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		CAGTGCCCCAGATAGGGCCAG	0.602000													5	19					0	0	1	0	0
C2orf80	389073	broad.mit.edu	37	2	209051687	209051687	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:209051687C>T	ENST00000341287.4	-	2	219	c.24G>A	c.(22-24)aaG>aaA	p.K8K	C2orf80_ENST00000453017.1_Silent_p.K8K|C2orf80_ENST00000451346.1_Intron	NM_001099334.2	NP_001092804.1	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	8										endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						TTTTCATTTCCTTCTTTATGA	0.423000													14	23					0	0	1	0	0
UPF3B	65109	broad.mit.edu	37	X	118974609	118974609	+	Splice_Site	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:118974609A>G	ENST00000276201.2	-	8	915	c.846_splice	c.e8+1	p.N282_splice	UPF3B_ENST00000478840.1_5'UTR|UPF3B_ENST00000345865.2_Intron	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	282	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						TGGTCCTTACATTTTTCTGAT	0.388000													7	23					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9948474	9948474	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:9948474C>T	ENST00000454190.2	+	5	536	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C	IL17RE_ENST00000295980.3_Missense_Mutation_p.R151C|IL17RE_ENST00000421412.1_Missense_Mutation_p.R184C|IL17RE_ENST00000383814.3_Missense_Mutation_p.R151C	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	151						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		CAAGGGACTTCGCTCTAAAAG	0.532000													6	129					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517795	158517795	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:158517795G>T	ENST00000302617.3	-	1	100	c.101C>A	c.(100-102)tCc>tAc	p.S34Y		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CAGGAAAATGGAGAAAAAGAG	0.443000													9	25					5.4927e-09	7.204e-09	1	1	0
CFC1	55997	broad.mit.edu	37	2	131356267	131356267	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:131356267G>A	ENST00000259216.4	-	3	457	c.195C>T	c.(193-195)gcC>gcT	p.A65A		NM_032545.3	NP_115934.1	P0CG37	CFC1_HUMAN	cripto, FRL-1, cryptic family 1	65					determination of left/right symmetry|gastrulation	anchored to membrane|extracellular region|plasma membrane				endometrium(1)|lung(4)	5	Colorectal(110;0.1)					CCCAGCCCTCGGCGCTCCCAG	0.632000													7	63					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17349710	17349710	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:17349710C>T	ENST00000242057.4	+	2	859	c.216C>T	c.(214-216)ctC>ctT	p.L72L		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	72	Helix-loop-helix motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TTCTTAGGCTCAGCGTCAGTT	0.393000													7	21					0	0	1	0	0
FOSL2	2355	broad.mit.edu	37	2	28634930	28634930	+	Missense_Mutation	SNP	G	G	T	rs143327177		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:28634930G>T	ENST00000264716.4	+	4	1459	c.596G>T	c.(595-597)cGa>cTa	p.R199L	FOSL2_ENST00000545753.1_Missense_Mutation_p.R160L|FOSL2_ENST00000379619.1_Missense_Mutation_p.R191L	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	199					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					GAGGAGCGCCGATCGCCCCCA	0.642000													24	34					6.38683e-12	9.26091e-12	1	1	0
HUWE1	10075	broad.mit.edu	37	X	53579703	53579703	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:53579703C>G	ENST00000342160.3	-	61	9103	c.8646G>C	c.(8644-8646)caG>caC	p.Q2882H	HUWE1_ENST00000262854.6_Missense_Mutation_p.Q2882H			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2882					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGCTCTGGGCTGCTCAGAAC	0.607000													20	43					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215440422	215440422	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:215440422A>G	ENST00000312504.5	+	4	1349	c.547A>G	c.(547-549)Ata>Gta	p.I183V	VWC2L_ENST00000427124.1_Silent_p.R139R|AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	183						extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						AGGAACGACGATAATTCCAGC	0.463000													48	119					0	0	1	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035499	110035499	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:110035499G>A	ENST00000453089.2	+	5	2477	c.1596G>A	c.(1594-1596)atG>atA	p.M532I	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.M563I|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.M564I			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	563							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CTTCAATGATGATGGCAACCA	0.423000													12	26					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91348430	91348430	+	Silent	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:91348430G>C	ENST00000358859.2	-	1	523	c.90C>G	c.(88-90)gcC>gcG	p.A30A	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		AGCTCAAGGAGGCCGAGTGTG	0.652000													5	11					0	0	1	0	0
TMEM187	8269	broad.mit.edu	37	X	153247965	153247965	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:153247965C>A	ENST00000369982.4	+	2	1199	c.452C>A	c.(451-453)gCc>gAc	p.A151D		NM_003492.2	NP_003483.1	Q14656	TM187_HUMAN	transmembrane protein 187	151						integral to membrane|transport vesicle				breast(1)|large_intestine(1)|lung(1)|prostate(2)	5	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCTCCCTGGCCAGTTATGGC	0.672000													6	21					2.0095e-06	2.40036e-06	1	1	0
STARD8	9754	broad.mit.edu	37	X	67936219	67936219	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:67936219G>T	ENST00000374599.3	+	5	358	c.243G>T	c.(241-243)atG>atT	p.M81I	STARD8_ENST00000374597.3_Start_Codon_SNP_p.M1I|STARD8_ENST00000252336.6_Start_Codon_SNP_p.M1I	NM_001142503.2	NP_001135975.1	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	1					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						GGAGGCTGATGACCTTGAATA	0.507000													8	28					0.335167	0.338409	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23526445	23526445	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:23526445C>A	ENST00000296682.3	+	11	1430	c.1248C>A	c.(1246-1248)ttC>ttA	p.F416L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	416					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CTCAGAACTTCCCAGGACCAT	0.488000										HNSCC(3;0.000094)			23	84					2.89027e-11	4.03401e-11	1	1	0
AIFM1	9131	broad.mit.edu	37	X	129281502	129281502	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:129281502G>T	ENST00000287295.3	-	5	801	c.571C>A	c.(571-573)Ctg>Atg	p.L191M	AIFM1_ENST00000346424.2_Intron|AIFM1_ENST00000319908.3_Missense_Mutation_p.L187M|AIFM1_ENST00000535724.1_Missense_Mutation_p.L104M	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	191	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						TTGAATCGCAGTGTCTTTGTG	0.413000													18	72					9.7654e-05	0.000109861	1	1	0
PARD3B	117583	broad.mit.edu	37	2	205986319	205986319	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:205986319C>A	ENST00000406610.2	+	8	1018	c.811C>A	c.(811-813)Caa>Aaa	p.Q271K	PARD3B_ENST00000358768.2_Missense_Mutation_p.Q271K|PARD3B_ENST00000462231.1_Missense_Mutation_p.Q271K|PARD3B_ENST00000351153.1_Missense_Mutation_p.Q271K|PARD3B_ENST00000349953.3_Missense_Mutation_p.Q271K	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	271	PDZ 1.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TTCCAGGGCTCAAGATGTCTT	0.483000													13	107					0.00074312	0.00080479	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190423813	190423813	+	Nonsense_Mutation	SNP	C	C	A	rs140412690		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:190423813C>A	ENST00000367462.3	-	2	439	c.208G>T	c.(208-210)Gga>Tga	p.G70*	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.R31S	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		70						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GTGCTAAATCCCTGCCGGCTT	0.448000													4	20					0.014758	0.0152548	1	1	0
TBX5	6910	broad.mit.edu	37	12	114841655	114841655	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr12:114841655G>T	ENST00000310346.4	-	2	715	c.49C>A	c.(49-51)Cct>Act	p.P17T	TBX5_ENST00000526441.1_Missense_Mutation_p.P17T|TBX5_ENST00000552726.1_5'UTR|TBX5_ENST00000405440.2_Missense_Mutation_p.P17T|TBX5_ENST00000349716.5_Intron	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	17				GFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFT QQ -> ALAGAHLWSLTQKTCLRFEPRARSGPPASPPGRPR SRLHPA (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTGCGTCAGGCTCCAGAGGC	0.687000													9	27					2.17888e-05	2.50523e-05	1	1	0
ITGAL	3683	broad.mit.edu	37	16	30528393	30528393	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:30528393T>A	ENST00000356798.6	+	26	3142	c.2962T>A	c.(2962-2964)Tgg>Agg	p.W988R	ITGAL_ENST00000433423.2_Missense_Mutation_p.W222R|ITGAL_ENST00000358164.5_Missense_Mutation_p.W904R	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	988					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CACACACCAGTGGAGCGTGCA	0.627000													31	77					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1235049	1235049	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:1235049C>A	ENST00000590083.1	-	5	698	c.406G>T	c.(406-408)Gag>Tag	p.E136*	C19orf26_ENST00000382477.2_Nonsense_Mutation_p.E130*|C19orf26_ENST00000215376.6_Nonsense_Mutation_p.E130*			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	130						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGCCGCCTCATTGAAGGAG	0.692000										HNSCC(14;0.022)			4	9					0.000602214	0.000657648	1	1	0
SPATA31A6	389730	broad.mit.edu	37	9	43625072	43625072	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr9:43625072G>A	ENST00000332857.6	-	4	3643	c.3615C>T	c.(3613-3615)ctC>ctT	p.L1205L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CTGCCGTCATGAGACCCTGAG	0.468000													50	122					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103355109	103355109	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:103355109C>A	ENST00000358392.2	-	59	4719	c.4402G>T	c.(4402-4404)Ggt>Tgt	p.G1468C	COL11A1_ENST00000370096.3_Missense_Mutation_p.G1456C|COL11A1_ENST00000512756.1_Missense_Mutation_p.G1340C|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1417C	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1456	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCAATTAAACCAGGATGTCCC	0.388000													14	35					0.0202918	0.020851	1	1	0
GRID2	2895	broad.mit.edu	37	4	94006431	94006431	+	Splice_Site	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:94006431G>A	ENST00000282020.4	+	3	787		c.e3+1		GRID2_ENST00000510992.1_Intron|GRID2_ENST00000505687.1_Splice_Site	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2						glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGTGAATACGGTAAGTGTTTA	0.343000													17	55					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61433248	61433248	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:61433248C>A	ENST00000398571.2	-	72	9134	c.9058G>T	c.(9058-9060)Gca>Tca	p.A3020S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3020					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGGATTAATGCTTGTTTCACA	0.353000													14	40					1.37522e-17	2.27894e-17	1	1	0
SYPL2	284612	broad.mit.edu	37	1	110022152	110022152	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:110022152A>T	ENST00000369872.3	+	6	1017	c.801A>T	c.(799-801)ggA>ggT	p.G267G	SYPL2_ENST00000401021.3_Silent_p.G203G	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	267						integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTGAGCAGGGAGCAGTGGAGA	0.637000													15	55					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939348	22939348	+	Silent	SNP	C	C	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr19:22939348C>T	ENST00000397104.3	-	7	2822	c.2823G>A	c.(2821-2823)gaG>gaA	p.E941E						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTAGGGTTTCTCTCCAGTAT	0.373000													13	20					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104594607	104594607	+	Missense_Mutation	SNP	A	A	G	rs104894150		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:104594607A>G	ENST00000369887.3	-	3	772	c.601T>C	c.(601-603)Tac>Cac	p.Y201H	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	201					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	CCTTCATTGTAATTCTGTATG	0.493000											OREG0020487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	63					0	0	1	0	0
CCDC89	220388	broad.mit.edu	37	11	85396231	85396231	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:85396231C>G	ENST00000316398.3	-	1	1089	c.943G>C	c.(943-945)Gag>Cag	p.E315Q		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	315						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				GCCTCTTGCTCAAACCGCTCC	0.522000													24	40					0	0	1	0	0
RFFL	117584	broad.mit.edu	37	17	33353469	33353469	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:33353469C>A	ENST00000315249.7	-	2	326	c.104G>T	c.(103-105)aGc>aTc	p.S35I	RFFL_ENST00000413582.2_Missense_Mutation_p.S35I|RFFL_ENST00000378516.2_Missense_Mutation_p.S35I|RFFL_ENST00000394597.2_Missense_Mutation_p.S35I|RFFL_ENST00000415395.2_Missense_Mutation_p.S35I|RFFL_ENST00000268850.7_Missense_Mutation_p.S35I|RFFL_ENST00000584655.1_Missense_Mutation_p.S35I|RFFL_ENST00000447669.2_Missense_Mutation_p.S35I|RAD51L3-RFFL_ENST00000593039.1_Intron			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	35					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGGGAAGGAGCTGTACCCAGG	0.602000													9	30					0.000274275	0.00030333	1	1	0
BTN3A1	11119	broad.mit.edu	37	6	26408110	26408110	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:26408110G>T	ENST00000289361.6	+	4	1013	c.645G>T	c.(643-645)ggG>ggT	p.G215G	BTN3A1_ENST00000414912.2_Silent_p.G163G|BTN3A1_ENST00000425234.2_Silent_p.G215G|BTN3A1_ENST00000476549.2_Silent_p.G215G	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	215	Ig-like V-type 2.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						GCAGCTCTGGGGAGGGTGTAT	0.552000													49	152					7.34454e-26	1.31748e-25	1	1	0
TUBB8	347688	broad.mit.edu	37	10	93866	93866	+	Silent	SNP	G	G	T	rs141258404		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:93866G>T	ENST00000447903.2	-	4	565	c.250C>A	c.(250-252)Cgg>Agg	p.R84R	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Silent_p.R156R|TUBB8_ENST00000332708.5_3'UTR			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	156					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TACTCCTCCCGGATCTTACTG	0.607000													30	60					1.36615e-20	2.33812e-20	1	1	0
LAMB3	3914	broad.mit.edu	37	1	209811879	209811879	+	Splice_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:209811879C>A	ENST00000391911.1	-	3	687	c.298_splice	c.e3+1	p.D100_splice	LAMB3_ENST00000356082.4_Splice_Site_p.D100_splice|LAMB3_ENST00000367030.3_Splice_Site_p.D100_splice	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	100	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AAATGCTCACCATTCTGTGAC	0.532000													33	44					1.90571e-15	2.99632e-15	1	1	0
MORF4L2	9643	broad.mit.edu	37	X	102931962	102931962	+	Translation_Start_Site	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:102931962C>A	ENST00000423833.2	-	0	1219				MORF4L2_ENST00000451301.1_De_novo_Start_OutOfFrame|MORF4L2_ENST00000441076.2_De_novo_Start_OutOfFrame|MORF4L2_ENST00000492116.1_5'UTR|MORF4L2_ENST00000372620.1_De_novo_Start_InFrame|MORF4L2_ENST00000433176.2_De_novo_Start_OutOfFrame|MORF4L2_ENST00000422154.2_De_novo_Start_OutOfFrame|MORF4L2_ENST00000360458.1_De_novo_Start_OutOfFrame			Q15014	MO4L2_HUMAN	mortality factor 4 like 2						chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)	13						TCATTCAACCCTGTTTTTATT	0.368000													14	57					2.23348e-06	2.66182e-06	1	1	0
TKTL1	8277	broad.mit.edu	37	X	153533764	153533764	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:153533764C>A	ENST00000369915.3	+	2	432	c.243C>A	c.(241-243)gtC>gtA	p.V81V	TKTL1_ENST00000369912.2_Silent_p.V25V|TKTL1_ENST00000217905.7_Silent_p.V25V	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	81					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCGATTTGTCCTCGCAAAGG	0.537000													15	27					8.10497e-08	1.01947e-07	1	1	0
ELTD1	64123	broad.mit.edu	37	1	79357340	79357340	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:79357340G>C	ENST00000370742.3	-	14	1942	c.1879C>G	c.(1879-1881)Ctc>Gtc	p.L627V		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	627					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GTGGTGCCGAGAAGGAACAGA	0.473000													8	38					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22036798	22036798	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr22:22036798G>A	ENST00000406385.1	+	8	520	c.460G>A	c.(460-462)Gac>Aac	p.D154N	PPIL2_ENST00000492445.2_Missense_Mutation_p.D154N|PPIL2_ENST00000398831.3_Missense_Mutation_p.D154N|PPIL2_ENST00000412327.1_Missense_Mutation_p.D154N|PPIL2_ENST00000335025.7_Missense_Mutation_p.D154N|PPIL2_ENST00000456792.2_Missense_Mutation_p.D133N			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	154					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					CTCCCGGCAGGACATCATCAC	0.612000													6	36					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131984486	131984486	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:131984486C>A	ENST00000356920.5	+	4	995	c.901C>A	c.(901-903)Ctg>Atg	p.L301M	PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_Missense_Mutation_p.L311M|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	301							ATP binding										TTTAAATGCACTGGATAGATA	0.328000													8	59					2.17888e-05	2.50523e-05	1	1	0
SPERT	220082	broad.mit.edu	37	13	46288187	46288187	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:46288187G>A	ENST00000378966.3	+	2	1335	c.919G>A	c.(919-921)Gcc>Acc	p.A307T	SPERT_ENST00000310521.1_Missense_Mutation_p.A343T			Q8NA61	SPERT_HUMAN	spermatid associated	343						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GGAGGAGGAGGCCAAGGTGGG	0.711000													3	4					0	0	1	0	0
PJA1	64219	broad.mit.edu	37	X	68382689	68382689	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:68382689A>T	ENST00000361478.1	-	2	770	c.393T>A	c.(391-393)gcT>gcA	p.A131A	PJA1_ENST00000374571.4_Silent_p.A76A|PJA1_ENST00000374584.3_Intron|PJA1_ENST00000374583.1_Silent_p.A131A|PJA1_ENST00000477231.1_5'UTR	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	131							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						CAACAGGCCCAGCCCCCTCCT	0.532000													25	34					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42295619	42295619	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:42295619T>C	ENST00000379310.3	-	25	2919	c.2851A>G	c.(2851-2853)Atc>Gtc	p.I951V	VWA8_ENST00000281496.6_Missense_Mutation_p.I951V	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TTCTGAAGGATGGGCTCAGGC	0.468000													24	37					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56819243	56819243	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:56819243G>T	ENST00000370754.5	-	1	142	c.143C>A	c.(142-144)cCg>cAg	p.P48Q				Q03001	DYST_HUMAN	dystonin	0	Actin-binding.|CH 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGATTTCATCGGATGCCTCCC	0.557000													13	21					6.31663e-08	7.96444e-08	1	1	0
PFKP	5214	broad.mit.edu	37	10	3141545	3141545	+	Splice_Site	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:3141545G>T	ENST00000381075.2	+	4	384		c.e4+1		PFKP_ENST00000381125.4_Splice_Site	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCTGCAAGTGGTAGGTACTGG	0.522000													29	95					2.46105e-21	4.25387e-21	1	1	0
TNNT2	7139	broad.mit.edu	37	1	201334424	201334424	+	Silent	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:201334424C>G	ENST00000509001.1	-	9	562	c.276G>C	c.(274-276)cgG>cgC	p.R92R	TNNT2_ENST00000367318.5_Silent_p.R92R|TNNT2_ENST00000421663.2_Silent_p.R94R|TNNT2_ENST00000458432.2_Silent_p.R104R|TNNT2_ENST00000367322.1_Silent_p.R92R|TNNT2_ENST00000236918.7_Silent_p.R97R|TNNT2_ENST00000367320.2_Intron|TNNT2_ENST00000367317.4_Silent_p.R92R|TNNT2_ENST00000360372.4_Silent_p.R87R|TNNT2_ENST00000367315.2_Silent_p.R92R	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	102					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						CCATGCGCTTCCGGTGGATGT	0.577000													18	169					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206652443	206652443	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:206652443A>G	ENST00000367120.3	+	10	1523	c.1150A>G	c.(1150-1152)Aca>Gca	p.T384A	IKBKE_ENST00000462698.1_3'UTR|IKBKE_ENST00000537984.1_Missense_Mutation_p.T299A	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	384					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					CCTCTTCAGCACAGCCATCCC	0.597000													15	61					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670231	49670231	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:49670231C>A	ENST00000561648.1	-	4	2885	c.2832G>T	c.(2830-2832)ggG>ggT	p.G944G	ZNF423_ENST00000562520.1_Silent_p.G884G|ZNF423_ENST00000262383.2_Silent_p.G944G|ZNF423_ENST00000562871.1_Silent_p.G884G|ZNF423_ENST00000567169.1_Silent_p.G827G|ZNF423_ENST00000535559.1_Silent_p.G827G|ZNF423_ENST00000563137.2_Silent_p.G884G	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	944					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GCTCCCGTAGCCCGTTCTCCG	0.592000													18	41					0.00188189	0.00200889	1	1	0
ALK	238	broad.mit.edu	37	2	29430080	29430080	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:29430080C>A	ENST00000389048.3	-	26	4801	c.3895G>T	c.(3895-3897)Gag>Tag	p.E1299*	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1299	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ATGAAGGCCTCTGGGGGCATC	0.522000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				24	43					7.92952e-12	1.13403e-11	1	1	0
DDX60L	91351	broad.mit.edu	37	4	169341505	169341505	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr4:169341505A>T	ENST00000511577.1	-	18	2668	c.2421T>A	c.(2419-2421)acT>acA	p.T807T	DDX60L_ENST00000260184.7_Silent_p.T807T|DDX60L_ENST00000505890.1_Silent_p.T807T			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	807	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GATTCTCAACAGTTGCAGCCA	0.403000													5	14					0	0	1	0	0
GNG13	51764	broad.mit.edu	37	16	849033	849033	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:849033G>T	ENST00000248150.4	-	2	146	c.45C>A	c.(43-45)agC>agA	p.S15R		NM_016541.2	NP_057625.1	Q9P2W3	GBG13_HUMAN	guanine nucleotide binding protein (G protein), gamma 13	15					cellular response to glucagon stimulus|energy reserve metabolic process		signal transducer activity			ovary(1)	1		Hepatocellular(780;0.00335)				GGTACTTGAGGCTCTCCACCT	0.622000													12	28					0.0202918	0.020851	1	1	0
SSFA2	6744	broad.mit.edu	37	2	182766646	182766646	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:182766646G>C	ENST00000431877.2	+	8	1045	c.866G>C	c.(865-867)aGt>aCt	p.S289T	SSFA2_ENST00000409001.1_Missense_Mutation_p.S289T|SSFA2_ENST00000320370.7_Missense_Mutation_p.S289T|SSFA2_ENST00000428267.2_Missense_Mutation_p.S136T	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	289						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TTAACTCGAAGTAACACTGCA	0.418000													16	35					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133196529	133196529	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:133196529C>A	ENST00000388996.4	-	3	983	c.563G>T	c.(562-564)cGg>cTg	p.R188L	KCNQ3_ENST00000521134.1_Missense_Mutation_p.R68L|KCNQ3_ENST00000519445.1_Missense_Mutation_p.R188L	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	188					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R188L(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGTCGGCCCCGCCAGCCTTT	0.537000													63	81					4.09171e-25	7.26487e-25	1	1	0
UTP6	55813	broad.mit.edu	37	17	30228589	30228589	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:30228589C>A	ENST00000261708.4	-	1	195	c.58G>T	c.(58-60)Gag>Tag	p.E20*		NM_018428.2	NP_060898.2	Q9NYH9	UTP6_HUMAN	UTP6, small subunit (SSU) processome component, homolog (yeast)	20					rRNA processing	nucleolus	binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)	21		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				CCAATGCGCTCCAGCTGTTCC	0.572000													21	53					6.36457e-07	7.69053e-07	1	1	0
ZIC3	7547	broad.mit.edu	37	X	136649358	136649358	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:136649358G>C	ENST00000287538.5	+	1	1058	c.508G>C	c.(508-510)Gct>Cct	p.A170P	ZIC3_ENST00000370606.3_Missense_Mutation_p.A170P	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	170					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					TGAGCAGGGCGCTGGGCACCC	0.697000													13	44					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129146954	129146954	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:129146954G>T	ENST00000540052.1	+	3	250	c.206G>T	c.(205-207)aGc>aTc	p.S69I	BCORL1_ENST00000303743.5_Missense_Mutation_p.S69I|BCORL1_ENST00000488135.1_3'UTR|BCORL1_ENST00000218147.7_Missense_Mutation_p.S69I|BCORL1_ENST00000359304.2_Missense_Mutation_p.S69I	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	69					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GGAAGTGGCAGCAATGCCCGG	0.572000													44	162					3.31993e-32	6.12368e-32	1	1	0
HRNR	388697	broad.mit.edu	37	1	152187691	152187691	+	Silent	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:152187691A>T	ENST00000368801.2	-	3	6489	c.6414T>A	c.(6412-6414)tcT>tcA	p.S2138S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2138					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCTGATCTAGAGCCGTGTT	0.577000													55	2020					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250092	140250092	+	Silent	SNP	A	A	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:140250092A>C	ENST00000398640.2	+	1	1404	c.1404A>C	c.(1402-1404)ccA>ccC	p.P468P	PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACAACCCACCAGGCTGCC	0.672000													51	134					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316484	30316484	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:30316484C>G	ENST00000375377.1	-	3	2694	c.2593G>C	c.(2593-2595)Gag>Cag	p.E865Q		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	865										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TGCTGCGGCTCCGCCTCACTC	0.572000													5	62					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961170	34961170	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:34961170C>A	ENST00000329357.5	+	1	258	c.222C>A	c.(220-222)gaC>gaA	p.D74E		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	74										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GTCGCCGTGACGAGTTTTTAC	0.527000													24	55					3.08376e-08	3.9166e-08	1	1	0
RSPO4	343637	broad.mit.edu	37	20	947845	947845	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:947845C>A	ENST00000217260.4	-	3	477	c.381G>T	c.(379-381)ttG>ttT	p.L127F	RSPO4_ENST00000400634.2_Missense_Mutation_p.L127F	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	127					Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						TCTGGTGGGCCAAAGTGCCCG	0.637000													23	47					2.89027e-11	4.03401e-11	1	1	0
CALB2	794	broad.mit.edu	37	16	71417284	71417284	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:71417284C>A	ENST00000302628.4	+	6	491	c.414C>A	c.(412-414)gaC>gaA	p.D138E	CALB2_ENST00000349553.5_Missense_Mutation_p.D138E	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	138	EF-hand 3.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				TCCTGTCAGACCTGCTGAAGA	0.522000													7	29					1.06961e-07	1.33255e-07	1	1	0
REXO1L1	254958	broad.mit.edu	37	8	86573734	86573734	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr8:86573734G>A	ENST00000379010.2	-	1	1992	c.1993C>T	c.(1993-1995)Cgg>Tgg	p.R665W		NM_172239.4	NP_758439.4	Q8IX06	GOR_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1	665						cytoplasm|nucleus	exonuclease activity|nucleic acid binding			endometrium(1)|lung(4)	5						GAGGCGGACCGGTGGCGTGGC	0.687000													5	72					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97875324	97875324	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:97875324G>C	ENST00000447648.2	-	3	434	c.135C>G	c.(133-135)tgC>tgG	p.C45W	TECPR1_ENST00000379795.3_Missense_Mutation_p.C45W|TECPR1_ENST00000542604.1_Intron			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	45						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAATGCCCCAGCAGCACTGCG	0.602000													3	13					0	0	1	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61675769	61675769	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:61675769C>A	ENST00000394836.2	-	2	178	c.21G>T	c.(19-21)caG>caT	p.Q7H	RAB3IL1_ENST00000301773.5_Missense_Mutation_p.Q54H	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	7							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						CCTGGTCTGGCTGGGGTGGGC	0.682000													4	10					0.014758	0.0152548	1	1	0
CHMP1B	57132	broad.mit.edu	37	18	11852027	11852027	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr18:11852027A>G	ENST00000526991.2	+	1	633	c.517A>G	c.(517-519)Acc>Gcc	p.T173A	GNAL_ENST00000535121.1_Intron|GNAL_ENST00000423027.3_Intron|GNAL_ENST00000269162.5_Intron|GNAL_ENST00000334049.6_Intron|RP11-78A19.3_ENST00000586474.1_RNA	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	173					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GCAGGGCCAGACCGGCTCCGT	0.637000													7	25					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325805	158325805	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:158325805A>T	ENST00000444681.2	+	3	810	c.517A>T	c.(517-519)Acc>Tcc	p.T173S	CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.T272S|CD1E_ENST00000368160.3_Missense_Mutation_p.T272S|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368161.3_Intron|CD1E_ENST00000368166.3_Missense_Mutation_p.T83S|CD1E_ENST00000452291.2_Missense_Mutation_p.T83S|CD1E_ENST00000434258.1_Missense_Mutation_p.T270S|CD1E_ENST00000368156.1_Missense_Mutation_p.T182S|CD1E_ENST00000368165.3_Missense_Mutation_p.T182S|CD1E_ENST00000368163.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368164.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	272					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TCTCCGAGCAACCCTGGATGT	0.612000													34	155					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12143171	12143171	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr10:12143171G>T	ENST00000263035.4	+	10	1949	c.1887G>T	c.(1885-1887)ggG>ggT	p.G629G		NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	629					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			ATCAGAAGGGGTTTCTAGAGG	0.473000													8	11					0.00307968	0.00325424	1	1	0
OR5M10	390167	broad.mit.edu	37	11	56344661	56344661	+	Silent	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:56344661G>A	ENST00000526812.2	-	1	602	c.537C>T	c.(535-537)tgC>tgT	p.C179C		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						GAGGATCAGCGCAGTAGAAAT	0.468000													20	25					0	0	1	0	0
RNF25	64320	broad.mit.edu	37	2	219532829	219532829	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:219532829C>A	ENST00000295704.2	-	4	700	c.260G>T	c.(259-261)cGa>cTa	p.R87L		NM_022453.2	NP_071898.2	Q96BH1	RNF25_HUMAN	ring finger protein 25	87	RWD.				positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding	p.R87L(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAAAGTCCTCGGGGATTTCG	0.512000													119	219					8.87883e-39	1.6612e-38	1	1	0
NUP133	55746	broad.mit.edu	37	1	229635556	229635556	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:229635556C>A	ENST00000261396.3	-	5	614	c.523G>T	c.(523-525)Gtc>Ttc	p.V175F	NUP133_ENST00000537506.1_Missense_Mutation_p.V159F|NUP133_ENST00000366679.1_Missense_Mutation_p.V175F|NUP133_ENST00000366678.3_Missense_Mutation_p.V175F	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	175					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GCAACCATGACAGCAACAGCC	0.448000													8	34					1.12685e-05	1.31298e-05	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186022202	186022202	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:186022202G>C	ENST00000271588.4	+	43	6925	c.6696G>C	c.(6694-6696)aaG>aaC	p.K2232N	HMCN1_ENST00000367492.2_Missense_Mutation_p.K2232N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2232	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTGGAAGAAGAAAGGTCAGT	0.308000													3	74					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120219492	120219492	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr2:120219492G>A	ENST00000019103.5	-	7	988	c.721C>T	c.(721-723)Cac>Tac	p.H241Y		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	241					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	AGGAGTGTGTGAAGGTAGAGG	0.542000													18	94					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681265	3681265	+	Silent	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:3681265C>A	ENST00000250693.1	+	3	617	c.516C>A	c.(514-516)ccC>ccA	p.P172P		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	172					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGCGTCCACCCCGGTGCCACC	0.692000													18	29					4.75885e-15	7.41528e-15	1	1	0
CKAP2	26586	broad.mit.edu	37	13	53039580	53039580	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:53039580G>A	ENST00000378037.5	+	6	1549	c.1459G>A	c.(1459-1461)Gcc>Acc	p.A487T	CKAP2_ENST00000258607.5_Missense_Mutation_p.A486T|CKAP2_ENST00000490903.1_Missense_Mutation_p.A438T|CKAP2_ENST00000378034.3_Missense_Mutation_p.A486T	NM_001098525.1|NM_018204.3	NP_001091995.1|NP_060674.3	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2	487					apoptosis|cell cycle	centrosome|microtubule|spindle pole				breast(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(3)|skin(1)|urinary_tract(1)	20		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		CTATGAGAAAGCCATTCTGGC	0.328000													7	25					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612158	142612158	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:142612158C>A	ENST00000265310.1	-	11	1693	c.1345G>T	c.(1345-1347)Ggg>Tgg	p.G449W		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	449					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ACCACCTCCCCATTGGTGTTG	0.562000													13	40					4.14922e-12	6.03312e-12	1	1	0
CECR2	27443	broad.mit.edu	37	22	18028016	18028016	+	Silent	SNP	G	G	T			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr22:18028016G>T	ENST00000262608.8	+	16	2976	c.2976G>T	c.(2974-2976)gcG>gcT	p.A992A	CECR2_ENST00000400573.4_Silent_p.A991A|CECR2_ENST00000400585.2_Silent_p.A849A	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1033					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCGAATCTGCGGACAACTGTA	0.612000													6	9					8.12818e-05	9.16396e-05	1	1	0
GJA10	84694	broad.mit.edu	37	6	90604546	90604546	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr6:90604546A>G	ENST00000369352.1	+	1	359	c.359A>G	c.(358-360)aAt>aGt	p.N120S		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	120					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CAGATGGAGAATCCAGATCTT	0.473000													7	16					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636846	152636846	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:152636846C>A	ENST00000368784.1	+	2	320	c.265C>A	c.(265-267)Ccc>Acc	p.P89T		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	89	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCACCAGAGCCCCGATTGCTG	0.667000													34	109					3.93418e-24	6.91462e-24	1	1	0
VASH1	22846	broad.mit.edu	37	14	77242564	77242564	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:77242564G>A	ENST00000167106.4	+	5	1493	c.860G>A	c.(859-861)cGc>cAc	p.R287H	VASH1_ENST00000556038.1_3'UTR|RP11-488C13.6_ENST00000556368.1_RNA	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	287					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		CGCCTGGGCCGCGATGACTTC	0.697000													3	20					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107691365	107691365	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:107691365delC	ENST00000370067.1	+	2	777	c.150delC	c.(148-150)tgfs	p.C50fs	NTNG1_ENST00000370072.3_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000542803.1_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370074.4_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370061.3_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370065.1_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370068.1_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370071.2_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370070.2_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370066.1_Frame_Shift_Del_p.C50fs|NTNG1_ENST00000370073.2_Frame_Shift_Del_p.C50fs			Q9Y2I2	NTNG1_HUMAN	netrin G1	50	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		ACATGGCCTGCCAGCCGGAAT	0.478													25	80	---	---	---	---					
IGSF3	3321	broad.mit.edu	37	1	117120039	117120039	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:117120039delC	ENST00000369486.3	-	11	4245	c.3480delG	c.(3478-3480)ggfs	p.G1160fs	IGSF3_ENST00000318837.6_Frame_Shift_Del_p.G1180fs|IGSF3_ENST00000369483.1_Frame_Shift_Del_p.G1180fs	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1160						integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCCCATTCTTCCCATCAGAGT	0.522													15	44	---	---	---	---					
LCE2A	353139	broad.mit.edu	37	1	152671416	152671416	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr1:152671416delT	ENST00000368779.1	+	2	90	c.39delT	c.(37-39)ccfs	p.P14fs		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	14	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGCCCCCTCCCAAGTGCC	0.552													67	227	---	---	---	---					
GPR27	2850	broad.mit.edu	37	3	71803229	71803231	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr3:71803229_71803231delGCG	ENST00000304411.2	+	1	29_31	c.29_31delGCG	c.(28-33)agc>a	p.SG10del	EIF4E3_ENST00000448225.1_Intron|EIF4E3_ENST00000421769.2_Intron	NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	10						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CCGGGTGGCAGCGGCGGCGGCGA	0.773													2	4	---	---	---	---					
PAPD7	11044	broad.mit.edu	37	5	6755013	6755014	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr5:6755013_6755014delAC	ENST00000230859.6	+	13	1713_1714	c.1584_1585delAC	c.(1582-1587)aaacfs	p.KH528fs		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	528					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGAGGAAAAAACACACACACAC	0.653													8	95	---	---	---	---					
C7orf57	136288	broad.mit.edu	37	7	48075920	48075921	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:48075920_48075921insA	ENST00000348904.3	+	2	227_228	c.15_16insA	c.(13-18)agaggafs	p.G6fs	C7orf57_ENST00000539619.1_Frame_Shift_Ins_p.G6fs|C7orf57_ENST00000420324.1_Frame_Shift_Ins_p.G51fs|C7orf57_ENST00000435376.1_Intron|C7orf57_ENST00000430738.1_Frame_Shift_Ins_p.G51fs	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	6										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						GGAACACAAGCAAGGAACTTCA	0.649													4	6	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100479332	100479332	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:100479332delG	ENST00000388793.4	+	4	524	c.304delG	c.(304-306)ggfs	p.G106fs	SRRT_ENST00000347433.4_Frame_Shift_Del_p.G106fs|SRRT_ENST00000432932.1_Frame_Shift_Del_p.G106fs|SRRT_ENST00000457580.2_Frame_Shift_Del_p.G106fs	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	106				G -> GG (in Ref. 3; CAB46374).	cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding	p.G104fs*45(1)		breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						GCCCTATGCTGGGGGGGGTGG	0.607													7	54	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142478951	142478951	+	RNA	DEL	C	C	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:142478951delC	ENST00000603901.1	+	0	40					NR_001296.3																						GCCGTTCTTGCCACCTCTCCT	0.522													8	15	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149518533	149518533	+	RNA	DEL	C	C	-	rs11353848		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr7:149518533delC	ENST00000378016.2	+	0	12602							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGCAGTCCCAGAGCCAG	0.711													3	4	---	---	---	---					
ST3GAL4	6484	broad.mit.edu	37	11	126278003	126278003	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr11:126278003delC	ENST00000526727.1	+	6	725	c.351delC	c.(349-351)tgfs	p.C117fs	ST3GAL4_ENST00000392669.2_Frame_Shift_Del_p.C117fs|ST3GAL4_ENST00000356132.4_Frame_Shift_Del_p.C123fs|ST3GAL4_ENST00000534083.1_Frame_Shift_Del_p.C117fs|ST3GAL4_ENST00000227495.6_Frame_Shift_Del_p.C113fs|ST3GAL4_ENST00000532243.1_Frame_Shift_Del_p.C116fs|ST3GAL4_ENST00000444328.2_Frame_Shift_Del_p.C117fs|ST3GAL4_ENST00000530591.1_Frame_Shift_Del_p.C113fs|ST3GAL4_ENST00000526756.1_3'UTR|ST3GAL4_ENST00000534457.1_Frame_Shift_Del_p.C112fs|ST3GAL4_ENST00000449406.2_Frame_Shift_Del_p.C106fs			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	117					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		GCCTCAGGTGCCGCCGCTGTG	0.597													19	40	---	---	---	---					
ALG11	440138	broad.mit.edu	37	13	52598430	52598431	+	Frame_Shift_Ins	INS	-	-	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr13:52598430_52598431insG	ENST00000521508.1	+	3	569_570	c.564_565insG	c.(562-567)atggggfs	p.MG188fs	ALG11_ENST00000523764.1_Intron|ALG11_ENST00000519151.1_3'UTR	NM_001004127.2	NP_001004127.2			ALG11, alpha-1,2-mannosyltransferase											endometrium(1)|large_intestine(6)|lung(4)|ovary(2)	13		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.44e-08)		TTAAGTATATAGGGGGTTGCCA	0.396													28	67	---	---	---	---					
UNC79	57578	broad.mit.edu	37	14	94079174	94079175	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr14:94079174_94079175insA	ENST00000553484.1	+	28	4006_4007	c.3852_3853insA	c.(3850-3855)ataggafs	p.G1285fs	UNC79_ENST00000393151.2_Frame_Shift_Ins_p.G1263fs|UNC79_ENST00000256339.4_Frame_Shift_Ins_p.G1086fs|UNC79_ENST00000555664.1_Frame_Shift_Ins_p.G1263fs			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1263						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ACAACACCATCAAGGACCTGCT	0.490													11	54	---	---	---	---					
LOC100129781	100129781	broad.mit.edu	37	16	14407192	14407193	+	RNA	INS	-	-	G			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr16:14407192_14407193insG	ENST00000570945.1	+	0	310																											ggggtgggggcgggggggtggt	0.550													4	3	---	---	---	---					
SMCR8	140775	broad.mit.edu	37	17	18219588	18219588	+	Frame_Shift_Del	DEL	A	A	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr17:18219588delA	ENST00000406438.3	+	1	965	c.485delA	c.(484-486)cgfs	p.Q162fs		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	162										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						TCTGCAGACCAGCATAAAATC	0.522													16	15	---	---	---	---					
LAMA5	3911	broad.mit.edu	37	20	60888854	60888854	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chr20:60888854delG	ENST00000252999.3	-	63	8575	c.8509delC	c.(8509-8511)tcfs	p.L2837fs		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2837	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAAACTGGAGAGTCCTGAGG	0.652													11	36	---	---	---	---					
CNKSR2	22866	broad.mit.edu	37	X	21534647	21534647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:21534647delC	ENST00000425654.2	+	9	1335	c.855delC	c.(853-855)gafs	p.D285fs	CNKSR2_ENST00000279451.4_Frame_Shift_Del_p.D285fs|CNKSR2_ENST00000543067.1_Intron|CNKSR2_ENST00000379510.3_Frame_Shift_Del_p.D285fs	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	285	PDZ.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TACGAGAGGACCCGAGTGGTG	0.418													29	79	---	---	---	---					
SRPX	8406	broad.mit.edu	37	X	38079976	38079978	+	In_Frame_Del	DEL	GCA	GCA	-	rs72445954		TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:38079976_38079978delGCA	ENST00000378533.3	-	1	174_176	c.68_70delTGC	c.(67-72)cgc>c	p.LR23del	SRPX_ENST00000432886.2_In_Frame_Del_p.LR23del|SRPX_ENST00000544439.1_In_Frame_Del_p.LR23del|SRPX_ENST00000538295.1_In_Frame_Del_p.LR23del|SRPX_ENST00000343800.6_Intron|TM4SF2_ENST00000465127.1_Intron	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane		p.L23delL(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						GGCGGGACGCgcagcagcagcag	0.729											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578865	154578865	+	RNA	DEL	G	G	-	rs150846040	by1000genomes	TCGA-97-7938-01A-11D-2167-08	TCGA-97-7938-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2dfca795-a40d-4a4b-9dfd-af3d0a683c46	82ce5155-d67c-45f1-843b-f7bfb2e4675d	g.chrX:154578865delG	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTTCTCTCTGTTTTTTTTTT	0.418													3	3	---	---	---	---					
