Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRPM2	7226	broad.mit.edu	37	21	45820152	45820152	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr21:45820152C>T	ENST00000397928.1	+	15	2664	c.2219C>T	c.(2218-2220)aCc>aTc	p.T740I	TRPM2_ENST00000300482.5_Missense_Mutation_p.T740I|TRPM2_ENST00000300481.9_Missense_Mutation_p.T720I|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000397932.2_Missense_Mutation_p.T740I	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	740						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GCCTTCCTGACCAAGGTGTGG	0.662000													9	66					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7688089	7688089	+	Silent	SNP	G	G	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr19:7688089G>C	ENST00000358368.4	-	9	1243	c.1206C>G	c.(1204-1206)gcC>gcG	p.A402A	XAB2_ENST00000534844.1_Silent_p.A399A	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	402					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						CATAAAACTTGGCAAACGCCA	0.547000								Direct reversal of damage;Nucleotide excision repair (NER)					28	87					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263322	65263322	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr14:65263322C>T	ENST00000389722.3	-	10	1347	c.1294G>A	c.(1294-1296)Gca>Aca	p.A432T	SPTB_ENST00000389720.3_Missense_Mutation_p.A432T|SPTB_ENST00000556626.1_Missense_Mutation_p.A432T|SPTB_ENST00000542895.1_Missense_Mutation_p.A432T|SPTB_ENST00000389721.5_Missense_Mutation_p.A432T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	432					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCTCTCATTGCGGCCTTCCGG	0.597000													18	76					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21247869	21247869	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr2:21247869T>C	ENST00000233242.1	-	16	2499	c.2372A>G	c.(2371-2373)gAc>gGc	p.D791G	APOB_ENST00000399256.4_Missense_Mutation_p.D791G	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	791					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAGCTGGAGGTCATGGAGACT	0.567000													4	77					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48758035	48758035	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr15:48758035G>A	ENST00000316623.5	-	39	5223	c.4768C>T	c.(4768-4770)Cct>Tct	p.P1590S		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1590					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCCCCTCCAGGACAAAGAATT	0.348000													4	26					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96214397	96214397	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr9:96214397G>C	ENST00000277165.6	+	1	394	c.200G>C	c.(199-201)aGc>aCc	p.S67T	FAM120A_ENST00000333936.5_Missense_Mutation_p.S67T|FAM120A_ENST00000375389.3_Missense_Mutation_p.S67T|FAM120A_ENST00000340893.4_Missense_Mutation_p.S67T|FAM120AOS_ENST00000375412.5_Intron	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	67						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GACTGGGTCAGCGGCGGCCAG	0.701000													3	24					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76907621	76907621	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chrX:76907621G>A	ENST00000373344.5	-	15	4754	c.4540C>T	c.(4540-4542)Cga>Tga	p.R1514*	ATRX_ENST00000395603.3_Nonsense_Mutation_p.R1476*|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1514					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AATTTTTCTCGCTCACGCTCC	0.428000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						36	202					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908869	158908869	+	Splice_Site	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr1:158908869G>A	ENST00000368140.1	+	4	656		c.e4-1		PYHIN1_ENST00000368138.3_Splice_Site|PYHIN1_ENST00000368135.4_Splice_Site|PYHIN1_ENST00000392254.2_Splice_Site|PYHIN1_ENST00000392252.3_Splice_Site	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1						cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					ACTACTTGTAGAAAAGAAAAA	0.358000													4	68					0	0	1	0	0
FAR2P2	100216479	broad.mit.edu	37	2	131176692	131176692	+	RNA	SNP	G	G	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr2:131176692G>C	ENST00000424873.1	-	0	477					NR_046260.1																						GATAATGGCAGGGGCCTGCTG	0.488000													3	5					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977359	29977359	+	RNA	SNP	G	G	A	rs3831361	by1000genomes	TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr6:29977359G>A	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							ATTTGTTCATGCCTTCCCTTT	0.453000													6	59					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52943076	52943076	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr4:52943076C>T	ENST00000295213.4	+	7	1264	c.890C>T	c.(889-891)gCg>gTg	p.A297V	SPATA18_ENST00000419395.2_Missense_Mutation_p.A265V	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	297	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding	p.A297V(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCAATGTGGCGCGCAAGGCT	0.662000													18	48					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53345048	53345048	+	Missense_Mutation	SNP	A	A	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr19:53345048A>T	ENST00000595646.1	-	4	619	c.499T>A	c.(499-501)Tct>Act	p.S167T	ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000396409.4_Missense_Mutation_p.S114T|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000390651.4_Missense_Mutation_p.S114T			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TTGTTGATAGACTTCTCAACT	0.378000													20	119					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33371133	33371133	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr6:33371133C>A	ENST00000428849.2	+	4	743	c.293C>A	c.(292-294)gCt>gAt	p.A98D	KIFC1_ENST00000486695.1_3'UTR	NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	98					blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						TGTTCCACAGCTATTGCCACA	0.493000													28	60					9.80776e-20	1.09181e-19	1	1	0
SRRD	402055	broad.mit.edu	37	22	26886156	26886156	+	Silent	SNP	T	T	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr22:26886156T>C	ENST00000215917.6	+	5	770	c.756T>C	c.(754-756)ctT>ctC	p.L252L		NM_001013694.2	NP_001013716.2	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	252					rhythmic process					endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						TCAAAGGACTTGAGGAGAGGT	0.453000													3	42					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													6	59					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112824054	112824054	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr5:112824054C>T	ENST00000408903.3	-	1	473	c.58G>A	c.(58-60)Ggc>Agc	p.G20S		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	548					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity	p.G20S(1)		endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ccgctgccgccgccgccgccg	0.756000													4	10					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48595979	48595979	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr16:48595979C>T	ENST00000262384.3	-	2	811	c.575G>A	c.(574-576)gGt>gAt	p.G192D	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	192					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				ATTCTCCTCACCTTGTGTGAG	0.378000													4	50					0	0	1	0	0
CLDN7	1366	broad.mit.edu	37	17	7163815	7163815	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr17:7163815A>C	ENST00000360325.7	-	4	948	c.514T>G	c.(514-516)Tct>Gct	p.S172A	CLDN7_ENST00000538261.3_Silent_p.G143G|RP1-4G17.5_ENST00000577138.1_Intron|CLDN7_ENST00000397317.4_Missense_Mutation_p.S172A	NM_001307.5	NP_001298.3	O95471	CLD7_HUMAN	claudin 7	172					calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity	p.S172A(1)		kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	6						ACTAGGGCAGACCCTGCCCAG	0.572000													10	32					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74535706	74535706	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr3:74535706T>A	ENST00000263665.6	-	3	286	c.259A>T	c.(259-261)Att>Ttt	p.I87F		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	87	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTGGGATTAATAACCACAAGA	0.373000													4	31					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175106087	175106087	+	Silent	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr1:175106087G>A	ENST00000239462.4	+	17	3671	c.3558G>A	c.(3556-3558)cgG>cgA	p.R1186R		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1186	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCAAGGAGCGGTATAAGCTGA	0.468000													8	44					0	0	1	0	0
RRP7BP	91695	broad.mit.edu	37	22	42971987	42971987	+	RNA	SNP	T	T	C	rs137064	by1000genomes	TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr22:42971987T>C	ENST00000357802.2	-	0	733																		p.Q59R(1)									CAGCTCTTTTTGGCTGCGCTT	0.672000													3	30					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68709952	68709952	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr5:68709952G>T	ENST00000509734.1	+	18	2557	c.1879G>T	c.(1879-1881)Gaa>Taa	p.E627*	RAD17_ENST00000345306.6_Nonsense_Mutation_p.E616*|RAD17_ENST00000504177.1_3'UTR|RAD17_ENST00000354868.5_Nonsense_Mutation_p.E616*|RAD17_ENST00000380774.3_Nonsense_Mutation_p.E627*|RAD17_ENST00000354312.3_Nonsense_Mutation_p.E616*|RAD17_ENST00000521422.1_Nonsense_Mutation_p.E451*|RAD17_ENST00000282891.6_Nonsense_Mutation_p.E530*|RAD17_ENST00000305138.4_Nonsense_Mutation_p.E616*|RAD17_ENST00000361732.2_Nonsense_Mutation_p.E616*|RAD17_ENST00000358030.2_Nonsense_Mutation_p.E451*			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	627	Interaction with MCM7.				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTCTGCAGAGGAATCTCTGGG	0.527000								Other conserved DNA damage response genes					24	133					6.21321e-17	6.78851e-17	1	1	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000540980.1_Silent_p.Q56Q|TBP_ENST00000230354.6_Silent_p.Q76Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													5	72					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916933	178916933	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr3:178916933A>G	ENST00000263967.3	+	2	477	c.320A>G	c.(319-321)aAc>aGc	p.N107S		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	107	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N107S(2)|p.G106_R108del(2)|p.G106_R108delGNR(2)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCAGTAGGCAACCGTGAAGAA	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	49					0	0	1	0	0
SFTPC	6440	broad.mit.edu	37	8	22021462	22021462	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr8:22021462G>A	ENST00000521315.1	+	5	516	c.484G>A	c.(484-486)Gat>Aat	p.D162N	SFTPC_ENST00000318561.3_Missense_Mutation_p.D168N|SFTPC_ENST00000522109.1_3'UTR|SFTPC_ENST00000520605.1_Intron|SFTPC_ENST00000524255.1_Missense_Mutation_p.D115N|SFTPC_ENST00000437090.2_3'UTR			P11686	PSPC_HUMAN	surfactant protein C	168	BRICHOS.				respiratory gaseous exchange	extracellular space				autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		AGAGGGGCGAGATGCAGGCTC	0.622000													22	77					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128441272	128441272	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr7:128441272C>G	ENST00000297788.4	+	4	746	c.379C>G	c.(379-381)Ctg>Gtg	p.L127V	CCDC136_ENST00000464832.1_Missense_Mutation_p.L177V|CCDC136_ENST00000378685.4_Missense_Mutation_p.L177V|CCDC136_ENST00000487361.1_Missense_Mutation_p.L127V	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	127	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GGAGATTTCCCTGTTAGAGCA	0.488000													6	36					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53905380	53905380	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr3:53905380C>T	ENST00000335754.3	-	11	1546	c.1446G>A	c.(1444-1446)atG>atA	p.M482I	ACTR8_ENST00000231909.7_Missense_Mutation_p.M187I|ACTR8_ENST00000482349.1_Missense_Mutation_p.M371I	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	482					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CGTTGCCGGCCATCAGGCCAT	0.552000													24	114					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18937330	18937330	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr16:18937330T>C	ENST00000446231.2	-	1	446	c.34A>G	c.(34-36)Agc>Ggc	p.S12G	SMG1_ENST00000567737.1_5'UTR|SMG1_ENST00000389467.3_Missense_Mutation_p.S12G			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	12	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ccgccgccgctgcTCAGCCGA	0.736000													3	17					0	0	1	0	0
CHRNA1	1134	broad.mit.edu	37	2	175618427	175618427	+	Silent	SNP	C	C	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr2:175618427C>A	ENST00000348749.5	-	6	659	c.582G>T	c.(580-582)ggG>ggT	p.G194G	CHRNA1_ENST00000409542.1_Silent_p.G112G|CHRNA1_ENST00000409219.1_Silent_p.G194G|CHRNA1_ENST00000261007.5_Silent_p.G219G|CHRNA1_ENST00000409323.1_Silent_p.G194G|AC018890.6_ENST00000442996.1_RNA	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	219					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						TCACCCACTCCCCGCTCTCCA	0.592000													13	44					7.93312e-07	8.51007e-07	1	1	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	50					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													6	115					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76825804	76825804	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr7:76825804C>G	ENST00000248598.5	-	2	1144	c.1112G>C	c.(1111-1113)tGt>tCt	p.C371S	CCDC146_ENST00000431197.1_Intron|RP11-467H10.2_ENST00000459742.1_RNA|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	371	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						GTACAGCCCACAGTTCCCAGA	0.413000													21	78					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953187	70953187	+	Silent	SNP	G	G	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr12:70953187G>C	ENST00000334414.6	-	18	4694	c.4650C>G	c.(4648-4650)gtC>gtG	p.V1550V	PTPRB_ENST00000551525.1_Silent_p.V1549V|PTPRB_ENST00000451516.2_Silent_p.V1242V|PTPRB_ENST00000538708.1_Silent_p.V1242V|PTPRB_ENST00000261266.5_Silent_p.V1332V|PTPRB_ENST00000550857.1_Silent_p.V1242V|PTPRB_ENST00000550358.1_Silent_p.V1462V	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1332	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGACAGTCTTGACGTTGAATT	0.418000													37	180					0	0	1	0	0
ZNF433	163059	broad.mit.edu	37	19	12126124	12126124	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr19:12126124A>C	ENST00000419886.2	-	5	1744	c.1453T>G	c.(1453-1455)Tcc>Gcc	p.S485A	ZNF433_ENST00000344980.6_Missense_Mutation_p.S520A|CTD-2006C1.2_ENST00000406892.2_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000495324.1_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						TATCGAAAGGAGCTCGAACAG	0.438000													7	47					0	0	1	0	0
FAM86JP	100125556	broad.mit.edu	37	3	125643933	125643933	+	RNA	SNP	A	A	G	rs73858994	by1000genomes	TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr3:125643933A>G	ENST00000485843.1	+	0	457					NR_024251.1																						ACCCAGAGACATGCCAGCTGT	0.647000													8	132					0	0	1	0	0
DDHD2	23259	broad.mit.edu	37	8	38090549	38090549	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr8:38090549C>T	ENST00000397166.2	+	2	562	c.37C>T	c.(37-39)Cag>Tag	p.Q13*	DDHD2_ENST00000520272.2_Nonsense_Mutation_p.Q13*	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	13					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			GCAGTTGTCCCAGTCAGATCC	0.433000													12	44					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													3	15					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61835663	61835663	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr10:61835663G>A	ENST00000280772.1	-	37	5167	c.4976C>T	c.(4975-4977)cCa>cTa	p.P1659L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1659	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGACTTAAATGGCAAACTTGA	0.418000													12	51					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36079602	36079602	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr21:36079602G>A	ENST00000360731.3	+	3	1453	c.1453G>A	c.(1453-1455)Gga>Aga	p.G485R	CLIC6_ENST00000349499.2_Missense_Mutation_p.G467R			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	485						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						TGAGAGTATCGGAAATTGCCC	0.443000													18	61					0	0	1	0	0
AC073321.4	0	broad.mit.edu	37	2	217475010	217475010	+	RNA	DEL	G	G	-			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr2:217475010delG	ENST00000441803.1	+	0	195																											ttttttttttGAAAGAAAGGC	0.393													2	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242466	55242480	+	In_Frame_Del	DEL	GAATTAAGAGAAGCA	GAATTAAGAGAAGCA	-	rs121913438		TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr7:55242466_55242480delGAATTAAGAGAAGCA	ENST00000275493.2	+	19	2413_2427	c.2236_2250delGAATTAAGAGAAGCA	c.(2236-2250)del	p.ELREA746del	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_In_Frame_Del_p.ELREA693del|EGFR_ENST00000455089.1_In_Frame_Del_p.ELREA701del	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.A750_E758>P(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.A750_K754del(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.E749G(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.A750_E758del(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.T751_E758del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACATCTCCGA	0.474	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			15	78	---	---	---	---					
FAM74A3	728495	broad.mit.edu	37	9	40715923	40715924	+	RNA	DEL	AA	AA	-	rs62565543		TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr9:40715923_40715924delAA	ENST00000604146.1	+	0	262_263					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAGACGTGGAAAGAGCTCAGA	0.569													4	8	---	---	---	---					
WNK1	65125	broad.mit.edu	37	12	989062	989063	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr12:989062_989063delTC	ENST00000315939.6	+	11	3340_3341	c.2697_2698delTC	c.(2695-2700)cttgfs	p.LL899fs	WNK1_ENST00000340908.4_Frame_Shift_Del_p.LL492fs|WNK1_ENST00000537687.1_Intron|WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Frame_Shift_Del_p.LL1397fs	NM_018979.3	NP_061852.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	899					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TTCCAACCCTTCTGCAGCCTGT	0.545													8	148	---	---	---	---					
IGHV3-48	28424	broad.mit.edu	37	14	106993939	106993941	+	RNA	DEL	TAC	TAC	-			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr14:106993939_106993941delTAC	ENST00000390624.2	-	0	302_304																											TAGTATATGGTACTACTACTACT	0.502													7	385	---	---	---	---					
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr15:22382920_22382921insT	ENST00000328795.4	+	1	539_540	c.448_449insT	c.(448-450)tggfs	p.W150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535													8	190	---	---	---	---					
ZNF770	54989	broad.mit.edu	37	15	35275372	35275386	+	In_Frame_Del	DEL	ACGCTGACAAATACT	ACGCTGACAAATACT	-	rs144467698		TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr15:35275372_35275386delACGCTGACAAATACT	ENST00000356321.4	-	3	594_608	c.250_264delAGTATTTGTCAGCGT	c.(250-264)del	p.SICQR84del		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R88C(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TTTTAAAGTGACGCTGACAAATACTACATTTAAAA	0.377													9	63	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													4	6	---	---	---	---					
CCDC155	147872	broad.mit.edu	37	19	49920666	49920668	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-97-8552-01A-11D-2393-08	TCGA-97-8552-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	13b04678-315f-421b-b0b9-fee46e80f243	1aa4f175-2bd1-497d-b7b6-3bf9204aa5ff	g.chr19:49920666_49920668delCTG	ENST00000447857.3	+	20	1793_1795	c.1588_1590delCTG	c.(1588-1590)del	p.L536del		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	536	Poly-Leu.					integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						TGTCCTGGGCctgctgctgctgc	0.650													2	4	---	---	---	---					
