Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR10P1	121130	broad.mit.edu	37	12	56031336	56031336	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:56031336C>A	ENST00000309675.2	+	1	693	c.661C>A	c.(661-663)Cgc>Agc	p.R221S		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CTCTTACATCCGCATCCTGGG	0.562000													22	126					1.50039e-11	2.54387e-11	1	1	0
FMO2	2327	broad.mit.edu	37	1	171174711	171174711	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:171174711C>A	ENST00000441535.1	+	7	1238	c.1121C>A	c.(1120-1122)cCc>cAc	p.P374H	RP1-127D3.4_ENST00000422841.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Missense_Mutation_p.P374H|RP1-127D3.4_ENST00000445290.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	374					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCATCCAGCCCCTAGGTTCC	0.463000													26	33					4.22769e-11	7.13857e-11	1	1	0
FAM135A	57579	broad.mit.edu	37	6	71185211	71185211	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:71185211G>T	ENST00000418814.2	+	6	870	c.256G>T	c.(256-258)Gtt>Ttt	p.V86F	FAM135A_ENST00000361499.3_Missense_Mutation_p.V86F|FAM135A_ENST00000370479.3_Missense_Mutation_p.V43F|FAM135A_ENST00000457062.2_Missense_Mutation_p.V43F|FAM135A_ENST00000505769.1_Missense_Mutation_p.V86F|FAM135A_ENST00000505868.1_Missense_Mutation_p.V86F	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	86										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TTTAAATGATGTTATGATCTT	0.279000													14	30					0.000151284	0.000178594	1	1	0
ANO1	55107	broad.mit.edu	37	11	70031709	70031709	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:70031709C>G	ENST00000355303.5	+	25	2907	c.2602C>G	c.(2602-2604)Cga>Gga	p.R868G	ANO1_ENST00000531349.1_Missense_Mutation_p.R577G|ANO1_ENST00000530676.1_Missense_Mutation_p.R722G|ANO1_ENST00000398543.2_Missense_Mutation_p.R722G|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000538023.1_Missense_Mutation_p.R868G	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	868					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TAAAGACTACCGAGAGCCGCC	0.622000													12	62					0	0	1	0	0
CDKL1	8814	broad.mit.edu	37	14	50862540	50862540	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:50862540C>A	ENST00000216378.2	-	2	694	c.50G>T	c.(49-51)gGa>gTa	p.G17V	CDKL1_ENST00000356146.1_5'UTR|CDKL1_ENST00000395834.1_Missense_Mutation_p.G17V			Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1 (CDC2-related kinase)	16	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|stomach(1)	12	all_epithelial(31;0.000746)|Breast(41;0.0102)					GAAAACAACTCCATAGGATCC	0.398000													14	54					0.000219431	0.000256834	1	1	0
SLC4A10	57282	broad.mit.edu	37	2	162804089	162804089	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:162804089T>G	ENST00000375514.5	+	17	2347	c.2060T>G	c.(2059-2061)tTg>tGg	p.L687W	SLC4A10_ENST00000446997.1_Missense_Mutation_p.L706W|SLC4A10_ENST00000272716.5_Missense_Mutation_p.L676W|SLC4A10_ENST00000421911.1_Missense_Mutation_p.L706W|SLC4A10_ENST00000415876.2_Missense_Mutation_p.L676W	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	706					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGCAAATCATTGCATGGAGAG	0.418000													13	54					0	0	1	0	0
OR3A1	4994	broad.mit.edu	37	17	3195605	3195605	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:3195605C>T	ENST00000323404.1	-	1	271	c.272G>A	c.(271-273)cGc>cAc	p.R91H	RP11-64J4.2_ENST00000573491.1_RNA	NM_002550.2	NP_002541.2	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A, member 1	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	20						TGCACGCTTGCGGGACAGGAG	0.562000													7	90					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40395981	40395981	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:40395981C>A	ENST00000221347.6	-	15	7423	c.7416G>T	c.(7414-7416)atG>atT	p.M2472I		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2472	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGCAGGTGCCCATGAAGTCGA	0.667000													25	83					8.58068e-18	1.66757e-17	1	1	0
RYR3	6263	broad.mit.edu	37	15	33927958	33927958	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:33927958G>T	ENST00000389232.4	+	26	3389	c.3319G>T	c.(3319-3321)Ggc>Tgc	p.G1107C	RYR3_ENST00000415757.3_Missense_Mutation_p.G1107C	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1107	4 X approximate repeats.|B30.2/SPRY 2.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGCGAGGCCAGGCTGTCGACC	0.522000													8	24					0.0381472	0.0391937	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23527006	23527006	+	Silent	SNP	A	A	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:23527006A>C	ENST00000296682.3	+	11	1991	c.1809A>C	c.(1807-1809)acA>acC	p.T603T		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	603					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGACACACACAGGGGAGAAGC	0.602000										HNSCC(3;0.000094)			14	95					0	0	1	0	0
PPM1F	9647	broad.mit.edu	37	22	22277613	22277613	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:22277613A>T	ENST00000407142.1	-	6	1773	c.713T>A	c.(712-714)aTc>aAc	p.I238N	PPM1F_ENST00000263212.5_Missense_Mutation_p.I406N|PPM1F_ENST00000538191.1_Missense_Mutation_p.I302N			P49593	PPM1F_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1F	406					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	12	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CATGACCGTGATGTTGTCGTG	0.697000													11	73					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4529233	4529233	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:4529233G>A	ENST00000381848.3	-	5	452	c.372C>T	c.(370-372)agC>agT	p.S124S	CTB-50L17.14_ENST00000586020.1_3'UTR	NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	124						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CCGTGACACTGCTGGCCACCA	0.642000													27	98					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68939490	68939490	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:68939490G>T	ENST00000288368.4	+	5	752	c.475G>T	c.(475-477)Gat>Tat	p.D159Y	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	159	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GAAGAACACAGATGTTCCCTT	0.368000													7	75					1.06961e-07	1.49891e-07	1	1	0
TRBV6-7	28600	broad.mit.edu	37	7	142144045	142144045	+	RNA	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:142144045G>T	ENST00000390373.2	-	0	39																											CCTGCCCACAGGAGAGAAAAG	0.607000													22	152					1.50039e-11	2.54387e-11	1	1	0
SIAH3	283514	broad.mit.edu	37	13	46357953	46357953	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:46357953G>T	ENST00000400405.2	-	2	481	c.375C>A	c.(373-375)ccC>ccA	p.P125P		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	125					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						GCCGCAGGTGGGGCACCACCA	0.657000													12	75					7.93312e-07	1.04758e-06	1	1	0
PIGT	51604	broad.mit.edu	37	20	44054450	44054450	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:44054450G>T	ENST00000279036.6	+	12	1801	c.1721G>T	c.(1720-1722)gGt>gTt	p.G574V	PIGT_ENST00000543458.2_Missense_Mutation_p.G518V|PIGT_ENST00000535404.1_Missense_Mutation_p.G419V|PIGT_ENST00000545755.1_Missense_Mutation_p.G312V|PIGT_ENST00000341555.5_Missense_Mutation_p.G380V|PIGT_ENST00000372689.5_Missense_Mutation_p.G507V|PIGT_ENST00000279035.9_Missense_Mutation_p.G472V	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	574					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				CGCGCCCGAGGTGTCCCCCCA	0.632000													3	24					0.00909568	0.00973356	1	1	0
MAG	4099	broad.mit.edu	37	19	35786543	35786543	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:35786543G>T	ENST00000361922.4	+	4	224	c.74G>T	c.(73-75)tGg>tTg	p.W25L	MAG_ENST00000392213.3_Missense_Mutation_p.W25L|MAG_ENST00000537831.2_5'UTR|MAG_ENST00000597035.1_Missense_Mutation_p.W25L	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	25	Ig-like V-type.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TGGGGTGCCTGGATGCCCTCG	0.672000													12	77					2.27111e-07	3.12942e-07	1	1	0
FAM27L	284123	broad.mit.edu	37	17	21825423	21825423	+	RNA	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:21825423C>A	ENST00000426869.3	+	0	127					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		tgtcggggctccgaggctccg	0.617000													4	24					0.00024832	0.000288191	1	1	0
MUC16	94025	broad.mit.edu	37	19	9062708	9062708	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:9062708G>A	ENST00000397910.4	-	3	24941	c.24738C>T	c.(24736-24738)agC>agT	p.S8246S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8248	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGGCTTCTGCTCACAAGAG	0.502000													16	72					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75602877	75602877	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:75602877C>A	ENST00000294638.5	+	4	862	c.198C>A	c.(196-198)tcC>tcA	p.S66S	LHX8_ENST00000559413.1_3'UTR|LHX8_ENST00000356261.3_Silent_p.S56S	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	66						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						CCTCGGGCTCCGGCTGCCCTC	0.677000													5	21					1.23904e-05	1.55636e-05	1	1	0
TYROBP	7305	broad.mit.edu	37	19	36398148	36398148	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:36398148C>G	ENST00000585901.2	-	4	359	c.341G>C	c.(340-342)cGt>cCt	p.R114P	TYROBP_ENST00000589517.1_Missense_Mutation_p.R82P|TYROBP_ENST00000262629.4_Missense_Mutation_p.R83P|TYROBP_ENST00000424586.3_Missense_Mutation_p.R71P|TYROBP_ENST00000544690.2_Missense_Mutation_p.R72P			O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	83					axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(4)|skin(1)	8	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCAGTGATACGCTGTTTCCG	0.542000													3	18					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88401604	88401604	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:88401604C>T	ENST00000418378.1	-	10	2308	c.1737G>A	c.(1735-1737)agG>agA	p.R579R	SPARCL1_ENST00000282470.6_Silent_p.R579R|SPARCL1_ENST00000503414.1_Silent_p.R454R	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	579					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TCTTAAAGTCCCTTAAGAGAA	0.428000													7	75					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108012088	108012088	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:108012088G>T	ENST00000280758.5	+	10	2913	c.2385G>T	c.(2383-2385)ctG>ctT	p.L795L	BTBD11_ENST00000490090.2_Silent_p.L795L|BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000357167.4_Silent_p.L332L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	795						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TGAGGGCCCTGAGGGAGGCCA	0.622000													10	37					1.76689e-08	2.61856e-08	1	1	0
PLB1	151056	broad.mit.edu	37	2	28853532	28853532	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:28853532G>T	ENST00000422425.2	+	53	3908		c.e53+1		PLB1_ENST00000541605.1_Splice_Site|PLB1_ENST00000327757.5_Splice_Site	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1						lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAACCTCCAGGTAAGCCCTGC	0.557000													4	10					0.00024832	0.000288191	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151877859	151877859	+	Silent	SNP	T	T	A	rs149651977		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:151877859T>A	ENST00000355193.2	-	36	7304	c.7086A>T	c.(7084-7086)tcA>tcT	p.S2362S	KMT2C_ENST00000262189.6_Silent_p.S2362S					lysine (K)-specific methyltransferase 2C																		CAGTTACTCCTGAAGTTGGCA	0.438000													15	54					0	0	1	0	0
HPSE2	60495	broad.mit.edu	37	10	100481538	100481538	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:100481538G>T	ENST00000370552.3	-	5	891	c.832C>A	c.(832-834)Cag>Aag	p.Q278K	HPSE2_ENST00000370546.1_Missense_Mutation_p.Q278K|HPSE2_ENST00000370549.1_Missense_Mutation_p.Q220K|HPSE2_ENST00000404542.1_Missense_Mutation_p.Q166K	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	278					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TTTCCCAACTGGCTGCCATTT	0.483000													8	77					3.09899e-07	4.2418e-07	1	1	0
OR6B2	389090	broad.mit.edu	37	2	240969514	240969514	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:240969514C>A	ENST00000402971.2	-	1	392	c.333G>T	c.(331-333)gaG>gaT	p.E111D		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GAAGCACACACTCGGTGCACA	0.632000													5	54					0.217242	0.218836	1	1	0
ITGA2	3673	broad.mit.edu	37	5	52356877	52356877	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:52356877G>T	ENST00000296585.5	+	12	1601		c.e12+1			NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)						axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AGGTGACCAGGTAAATCTCAC	0.473000													16	76					9.16793e-09	1.37352e-08	1	1	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													6	21					0.0215528	0.0223671	1	1	0
C1RL	51279	broad.mit.edu	37	12	7254465	7254465	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:7254465C>T	ENST00000545337.1	-	3	548	c.519G>A	c.(517-519)gaG>gaA	p.E173E	C1RL_ENST00000266542.4_Intron|C1RL_ENST00000544702.1_Intron|C1RL_ENST00000545280.1_Intron			Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	0					complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGAGGCTCCCTCCCTGCACC	0.607000													33	87					0	0	1	0	0
KCNMB2	10242	broad.mit.edu	37	3	178560535	178560535	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:178560535C>G	ENST00000432997.1	+	5	870	c.518C>G	c.(517-519)tCc>tGc	p.S173C	RP11-385J1.2_ENST00000432385.1_RNA|KCNMB2_ENST00000452583.1_Missense_Mutation_p.S173C|RP11-385J1.2_ENST00000425330.1_RNA|RP11-385J1.2_ENST00000437488.1_RNA|KCNMB2_ENST00000420517.2_Missense_Mutation_p.S173C|KCNMB2_ENST00000358316.3_Missense_Mutation_p.S173C|RP11-385J1.2_ENST00000451742.1_RNA	NM_005832.3	NP_005823.1	Q9Y691	KCMB2_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 2	173					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			NS(2)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CAACACTTCTCCTGCTATTCT	0.418000													39	67					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6023782	6023782	+	Silent	SNP	G	G	A	rs114705293	by1000genomes	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:6023782G>A	ENST00000330728.4	-	1	642	c.597C>T	c.(595-597)gcC>gcT	p.A199A		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAAAGACCACGGCCCTAGCCA	0.493000													9	36					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233649	21233649	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:21233649T>A	ENST00000233242.1	-	26	6218	c.6091A>T	c.(6091-6093)Agt>Tgt	p.S2031C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2031					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGGGCTCACTGAGTAAAAGT	0.398000													33	106					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54759273	54759273	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:54759273G>T	ENST00000450632.1	-	5	878	c.801C>A	c.(799-801)tcC>tcA	p.S267S	LILRB5_ENST00000449561.2_Silent_p.S276S|LILRB5_ENST00000316219.5_Silent_p.S276S|LILRB5_ENST00000345866.6_Silent_p.S176S			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	276	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGTTGGCCTGGGAGAGCCCAG	0.637000													13	60					1.5842e-08	2.36482e-08	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76461394	76461394	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:76461394C>A	ENST00000307431.8	+	5	818	c.433C>A	c.(433-435)Ctc>Atc	p.L145I	CNTNAP4_ENST00000476707.1_Missense_Mutation_p.L149I|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.L145I|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.L121I|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	146	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GTACTATAGACTCCAGCCTTC	0.433000													21	175					1.40151e-16	2.67325e-16	1	1	0
CARD9	64170	broad.mit.edu	37	9	139265296	139265296	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:139265296C>A	ENST00000371732.5	-	4	789	c.624G>T	c.(622-624)ctG>ctT	p.L208L	CARD9_ENST00000315908.7_Silent_p.L208L|CARD9_ENST00000371734.3_Silent_p.L208L	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	208					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GGCGCACCTCCAGCTGCAGGT	0.726000													4	22					3.59834e-05	4.42542e-05	1	1	0
CENPE	1062	broad.mit.edu	37	4	104116370	104116370	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:104116370G>A	ENST00000265148.3	-	5	467	c.378C>T	c.(376-378)ctC>ctT	p.L126L	CENPE_ENST00000380026.3_Silent_p.L126L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	126	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ATACACGTAAGAGAAATTCCC	0.313000													10	32					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49667526	49667526	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:49667526G>T	ENST00000339139.4	-	6	498	c.262C>A	c.(262-264)Cgc>Agc	p.R88S		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	88						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			ctggttttgcggtcctctgGA	0.338000													5	33					1.23904e-05	1.55636e-05	1	1	0
ANK2	287	broad.mit.edu	37	4	114179245	114179245	+	Missense_Mutation	SNP	C	C	A	rs41279311		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:114179245C>A	ENST00000357077.4	+	12	1281	c.1228C>A	c.(1228-1230)Cgc>Agc	p.R410S	ANK2_ENST00000264366.6_Missense_Mutation_p.R410S|ANK2_ENST00000506722.1_Missense_Mutation_p.R389S|ANK2_ENST00000394537.3_Missense_Mutation_p.R410S	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	410					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAGAAAAACCGCATCAAAGT	0.393000													5	49					1.23904e-05	1.55636e-05	1	1	0
MAML2	84441	broad.mit.edu	37	11	95825828	95825828	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:95825828T>C	ENST00000524717.1	-	2	2651	c.1367A>G	c.(1366-1368)cAc>cGc	p.H456R		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	456					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				GGTAGgctggtgctgctgctg	0.572000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								11	92					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547961	63547961	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:63547961T>G	ENST00000397968.2	+	12	2615	c.2189T>G	c.(2188-2190)cTg>cGg	p.L730R	CDH7_ENST00000323011.3_Missense_Mutation_p.L730R	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	730					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TATGACTCCCTGCAGACATAT	0.403000													26	117					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154379452	154379452	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:154379452C>A	ENST00000406326.1	+	6	1123	c.720C>A	c.(718-720)caC>caA	p.H240Q	DPP6_ENST00000377770.3_Intron|DPP6_ENST00000332007.3_Intron|DPP6_ENST00000427557.1_Intron|DPP6_ENST00000404039.1_Intron			P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	0					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			cagcttgtcaccagggctgtt	0.458000													4	12					0.00024832	0.000288191	1	1	0
CACNA1I	8911	broad.mit.edu	37	22	40080474	40080474	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:40080474C>A	ENST00000336649.4	+	39	6016	c.6016C>A	c.(6016-6018)Cca>Aca	p.P2006T	CACNA1I_ENST00000407673.1_Missense_Mutation_p.P1965T|CACNA1I_ENST00000402142.3_Missense_Mutation_p.P2000T|CACNA1I_ENST00000401624.1_Missense_Mutation_p.P2000T|CACNA1I_ENST00000400164.3_Missense_Mutation_p.P1965T|CACNA1I_ENST00000404898.1_Missense_Mutation_p.P1965T			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	2000					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTGCGGTCACCAAGGGTCAA	0.632000													4	16					0.014758	0.0155109	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130934762	130934762	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:130934762G>A	ENST00000261655.4	-	6	676	c.513C>T	c.(511-513)ctC>ctT	p.L171L	RIMBP2_ENST00000536002.1_Silent_p.L79L|RIMBP2_ENST00000535703.1_Silent_p.L79L	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	171	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGGCAACACAGAGGTGGACCT	0.552000													3	25					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121761073	121761073	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:121761073C>A	ENST00000261367.7	+	7	2598	c.1170C>A	c.(1168-1170)gaC>gaA	p.D390E	SNCAIP_ENST00000379533.2_Missense_Mutation_p.D390E|SNCAIP_ENST00000504884.2_Missense_Mutation_p.Q53K|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.D343E|SNCAIP_ENST00000503116.2_Missense_Mutation_p.D390E|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379536.2_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	343					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACAATCTAGACAAAATTCACG	0.428000													16	135					6.31663e-08	9.1314e-08	1	1	0
OR51F1	256892	broad.mit.edu	37	11	4790796	4790796	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:4790796C>A	ENST00000380383.1	-	1	372	c.373G>T	c.(373-375)Gtg>Ttg	p.V125L	MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.V118L|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	118						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCTGTAGCCACCAGCACTCCA	0.433000													18	70					9.16793e-09	1.37352e-08	1	1	0
TMEM132A	54972	broad.mit.edu	37	11	60694737	60694737	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:60694737C>T	ENST00000005286.4	+	2	315	c.162C>T	c.(160-162)gaC>gaT	p.D54D	TMEM132A_ENST00000453848.2_Silent_p.D54D	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	54						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						AGCTCCTAGACGCCCCTGAAC	0.617000													8	123					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69343256	69343256	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:69343256G>A	ENST00000305363.4	+	8	941	c.877G>A	c.(877-879)Gta>Ata	p.V293I		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	293	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						CACAAATGCAGTACATAGAGT	0.418000													51	310					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271913	59271913	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:59271913C>A	ENST00000313253.1	+	1	865	c.865C>A	c.(865-867)Ctg>Atg	p.L289M		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						GATCTACACTCTGAGGAACCA	0.522000													31	144					3.1745e-13	5.58928e-13	1	1	0
SKAP2	8935	broad.mit.edu	37	7	26709796	26709796	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:26709796C>A	ENST00000345317.2	-	12	1316	c.1003G>T	c.(1003-1005)Ggc>Tgc	p.G335C	SKAP2_ENST00000539623.1_Missense_Mutation_p.G163C	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	335	SH3.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						ACCCACCAGCCATATCTATTG	0.358000													34	57					6.53348e-20	1.29413e-19	1	1	0
MTUS2	23281	broad.mit.edu	37	13	29600023	29600023	+	Silent	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:29600023C>G	ENST00000431530.3	+	1	1276	c.1218C>G	c.(1216-1218)ccC>ccG	p.P406P		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	396						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACACCACCCCCAAACAGGGCT	0.547000													3	24					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118969793	118969793	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:118969793C>T	ENST00000334549.1	+	3	1138	c.1138C>T	c.(1138-1140)Cac>Tac	p.H380Y		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	380						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GAAGTTTTACCACCTTGTTAA	0.403000													5	81					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323152	31323152	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:31323152C>A	ENST00000265071.2	+	12	2375	c.2110C>A	c.(2110-2112)Cca>Aca	p.P704T		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	704					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCGACGGACTCCAACAGCTCG	0.522000													16	67					3.41278e-10	5.55757e-10	1	1	0
RBM10	8241	broad.mit.edu	37	X	47041007	47041007	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:47041007G>T	ENST00000377604.3	+	14	2279	c.1537G>T	c.(1537-1539)Gag>Tag	p.E513*	RBM10_ENST00000329236.7_Nonsense_Mutation_p.E435*|RBM10_ENST00000345781.6_Nonsense_Mutation_p.E436*|RBM10_ENST00000468791.1_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	513					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						ACAATCAGCCGAGGCGAGCAG	0.662000													4	5					0.00909568	0.00973356	1	1	0
FAM170A	340069	broad.mit.edu	37	5	118970247	118970247	+	Silent	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:118970247A>T	ENST00000515256.1	+	3	976	c.804A>T	c.(802-804)acA>acT	p.T268T				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	268						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CTCAGCTGACAGGCAACATGG	0.542000													50	149					0	0	1	0	0
STK26	51765	broad.mit.edu	37	X	131202253	131202253	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:131202253G>C	ENST00000394334.2	+	5	594	c.341G>C	c.(340-342)gGt>gCt	p.G114A	MST4_ENST00000394335.2_Missense_Mutation_p.G37A|MST4_ENST00000496850.1_Missense_Mutation_p.G114A|MST4_ENST00000354719.6_Missense_Mutation_p.G114A|MST4_ENST00000481105.1_Missense_Mutation_p.G136A	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		114	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					CTTCGAGCTGGTCCATTTGAT	0.348000													27	30					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121615315	121615315	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:121615315G>C	ENST00000489711.1	+	2	556	c.168G>C	c.(166-168)gaG>gaC	p.E56D	SLC15A2_ENST00000295605.2_Missense_Mutation_p.E56D	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	56					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AATTCTGCGAGCGCTTTTCCT	0.458000													5	82					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129938648	129938648	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:129938648T>G	ENST00000222482.4	+	2	159	c.131T>G	c.(130-132)gTg>gGg	p.V44G	CPA4_ENST00000493259.1_Intron|CPA4_ENST00000445470.2_Missense_Mutation_p.V44G	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	44					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					AGTCAACTAGTGAATTCAAAC	0.388000													5	38					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21988563	21988563	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:21988563G>T	ENST00000292779.3	+	3	486	c.325G>T	c.(325-327)Gtg>Ttg	p.V109L		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	109										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					GGTGCCGCTTGTGGAGGTGCA	0.657000													5	93					1.23904e-05	1.55636e-05	1	1	0
OR51T1	401665	broad.mit.edu	37	11	4903652	4903652	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:4903652G>T	ENST00000380378.1	+	1	604	c.604G>T	c.(604-606)Gag>Tag	p.E202*	MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Nonsense_Mutation_p.E175*|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGGGTCACGAGCTTTCCCA	0.458000													30	151					2.12542e-12	3.67929e-12	1	1	0
KRT20	54474	broad.mit.edu	37	17	39036944	39036944	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:39036944G>T	ENST00000167588.3	-	3	593	c.552C>A	c.(550-552)acC>acA	p.T184T		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	184	Coil 1B.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TTTTATGTAGGGTTAGGTCAT	0.398000													23	92					6.21321e-17	1.19062e-16	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113170013	113170013	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:113170013C>T	ENST00000401783.2	-	38	8203	c.7867G>A	c.(7867-7869)Gac>Aac	p.D2623N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D2600N|SVEP1_ENST00000297826.5_Missense_Mutation_p.D549N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2623				D -> A (in Ref. 7; AAG48257).	cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTAGTACAGTCTCCAAAATCT	0.458000													17	191					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138642936	138642936	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:138642936G>A	ENST00000218099.2	+	7	767	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	F9_ENST00000394090.2_Missense_Mutation_p.G216S	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	254	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ATTCTGTGGAGGCTCTATCGT	0.323000													22	61					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296851	154296851	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:154296851C>A	ENST00000324978.3	+	6	841	c.801C>A	c.(799-801)caC>caA	p.H267Q	AQP10_ENST00000484864.1_3'UTR	NM_080429.2	NP_536354.2	Q96PS8	AQP10_HUMAN	aquaporin 10	267					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGGCTCTGCACCACCCTGAGG	0.602000											OREG0013832	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	78					7.41877e-09	1.11961e-08	1	1	0
OR5F1	338674	broad.mit.edu	37	11	55761961	55761961	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:55761961G>T	ENST00000278409.1	-	1	140	c.141C>A	c.(139-141)ctC>ctA	p.L47L		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TCCTGATTAAGAGGATCATCC	0.423000													14	69					9.31168e-06	1.18774e-05	1	1	0
RSL1D1	26156	broad.mit.edu	37	16	11933609	11933609	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:11933609G>A	ENST00000571133.1	-	8	1161	c.1089C>T	c.(1087-1089)gaC>gaT	p.D363D	RSL1D1_ENST00000542106.1_Silent_p.D143D	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	363					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						GTGGGATTTCGTCTTCGGATT	0.398000													10	189					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71050494	71050494	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:71050494G>T	ENST00000283228.2	-	13	2322	c.1870C>A	c.(1870-1872)Cgt>Agt	p.R624S	PTPRR_ENST00000342084.4_Missense_Mutation_p.R512S|PTPRR_ENST00000549308.1_Missense_Mutation_p.R379S|PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000440835.2_Missense_Mutation_p.R379S|PTPRR_ENST00000378778.1_Missense_Mutation_p.R418S	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	624	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity	p.R624C(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CTATCCATACGAAGCTGGCAG	0.458000													24	90					2.39556e-15	4.42589e-15	1	1	0
ADAM23	8745	broad.mit.edu	37	2	207437885	207437885	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:207437885A>T	ENST00000264377.3	+	18	2031	c.1703A>T	c.(1702-1704)gAt>gTt	p.D568V	ADAM23_ENST00000374416.1_Missense_Mutation_p.D568V|ADAM23_ENST00000374415.3_Missense_Mutation_p.D568V	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	568	Disintegrin.|May bind the integrin receptor.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AACGAGTGTGATATTACTGAA	0.383000													30	138					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	870895	870895	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:870895C>G	ENST00000314167.4	-	17	2067	c.1957G>C	c.(1957-1959)Ggc>Cgc	p.G653R	GAK_ENST00000511163.1_Missense_Mutation_p.G574R	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	653	C2 tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		TGCAGCCGGCCGCCCAGAGTG	0.632000													4	19					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54362369	54362369	+	Missense_Mutation	SNP	G	G	T	rs111703372		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:54362369G>T	ENST00000254442.3	+	11	1508	c.1297G>T	c.(1297-1299)Gta>Tta	p.V433L	WDR7_ENST00000357574.3_Missense_Mutation_p.V433L|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	433										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		CATAGTTATTGTACCTGCCAC	0.438000													32	74					2.81731e-10	4.64293e-10	1	1	0
KIF13A	63971	broad.mit.edu	37	6	17781014	17781014	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:17781014C>A	ENST00000378814.5	-	30	3753	c.3754G>T	c.(3754-3756)Gct>Tct	p.A1252S	KIF13A_ENST00000378816.5_Missense_Mutation_p.A1265S|KIF13A_ENST00000378843.2_Missense_Mutation_p.A1252S|KIF13A_ENST00000259711.6_Missense_Mutation_p.A1265S|KIF13A_ENST00000378826.2_Missense_Mutation_p.A1265S	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1265					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AACTCCATAGCAGCAGGGTGG	0.428000													20	64					6.44725e-10	1.04167e-09	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1085385	1085385	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:1085385G>T	ENST00000264930.5	-	7	922	c.879C>A	c.(877-879)gcC>gcA	p.A293A		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	293					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TGATGACGCCGGCATAGATGG	0.652000													7	22					8.12818e-05	9.73492e-05	1	1	0
MS4A2	2206	broad.mit.edu	37	11	59860291	59860291	+	Silent	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:59860291T>A	ENST00000278888.3	+	4	450	c.348T>A	c.(346-348)atT>atA	p.I116I		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	116					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	TGTTGTCAATTATATCTGAAA	0.353000													11	30					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108298048	108298048	+	Splice_Site	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:108298048C>A	ENST00000370056.4	-	12	1448		c.e12+1		VAV3_ENST00000371846.4_Splice_Site|VAV3_ENST00000527011.1_Splice_Site|VAV3_ENST00000343258.4_Splice_Site	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TAATTACATACCAAATTCTCT	0.368000													6	21					3.59834e-05	4.42542e-05	1	1	0
MCM3	4172	broad.mit.edu	37	6	52141252	52141252	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:52141252C>A	ENST00000596288.1	-	9	1350	c.1323G>T	c.(1321-1323)ggG>ggT	p.G441G	MCM3_ENST00000229854.7_Silent_p.G396G|MCM3_ENST00000476448.1_5'UTR|MCM3_ENST00000419835.2_Silent_p.G350G	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	396	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GGACCATGGCCCCTGCTTCCA	0.517000													7	31					1.06961e-07	1.49891e-07	1	1	0
OR2G3	81469	broad.mit.edu	37	1	247768914	247768914	+	Silent	SNP	A	A	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:247768914A>C	ENST00000320002.2	+	1	59	c.27A>C	c.(25-27)ctA>ctC	p.L9L	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGAGTTCCCTAATGGATTTCA	0.463000													28	78					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568697	55568697	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:55568697G>T	ENST00000395445.1	-	36	5507	c.5113C>A	c.(5113-5115)Cct>Act	p.P1705T	PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395442.1_Missense_Mutation_p.P570T|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395440.1_Missense_Mutation_p.P639T|PCDH15_ENST00000395446.1_Missense_Mutation_p.P901T|PCDH15_ENST00000414778.1_Intron	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCTTCCACAGGGGCTGGTCCA	0.478000										HNSCC(58;0.16)			4	11					0.00909568	0.00973356	1	1	0
LPPR4	9890	broad.mit.edu	37	1	99771331	99771331	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:99771331G>C	ENST00000370185.3	+	7	1554	c.1057G>C	c.(1057-1059)Gat>Cat	p.D353H	LPPR4_ENST00000370184.1_Missense_Mutation_p.D195H|LPPR4_ENST00000457765.1_Missense_Mutation_p.D295H	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		353							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCTCAATCAAGATCCCAACCG	0.478000													11	141					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043360	117043360	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:117043360C>A	ENST00000371876.1	-	4	3538	c.1117G>T	c.(1117-1119)Gtt>Ttt	p.V373F	KLHL13_ENST00000371878.1_Missense_Mutation_p.V373F|KLHL13_ENST00000539496.1_Missense_Mutation_p.V427F|KLHL13_ENST00000545703.1_Missense_Mutation_p.V382F|KLHL13_ENST00000262820.3_Missense_Mutation_p.V424F|KLHL13_ENST00000541812.1_Missense_Mutation_p.V408F|KLHL13_ENST00000540167.1_Missense_Mutation_p.V408F|KLHL13_ENST00000469946.1_Missense_Mutation_p.V373F|KLHL13_ENST00000371882.1_Missense_Mutation_p.V373F			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	424					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AAAGATGCAACTTGCATCCAT	0.423000													26	29					1.66031e-10	2.76942e-10	1	1	0
PHTF2	57157	broad.mit.edu	37	7	77549683	77549683	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:77549683C>T	ENST00000416283.2	+	8	888	c.762C>T	c.(760-762)agC>agT	p.S254S	PHTF2_ENST00000307305.8_Silent_p.S250S|PHTF2_ENST00000422959.2_Silent_p.S254S|PHTF2_ENST00000248550.7_Silent_p.S288S|PHTF2_ENST00000415251.2_Silent_p.S250S|PHTF2_ENST00000424760.1_Silent_p.S250S|PHTF2_ENST00000454592.1_3'UTR|PHTF2_ENST00000275575.7_Silent_p.S250S|PHTF2_ENST00000450574.1_Silent_p.S254S	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						CTGTTAAAAGCGGTGAAGATG	0.383000													12	50					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43679575	43679575	+	Silent	SNP	A	A	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:43679575A>C	ENST00000404580.1	-	4	844	c.756T>G	c.(754-756)cgT>cgG	p.R252R	PSG5_ENST00000407356.1_Silent_p.R252R|PSG5_ENST00000366175.3_Silent_p.R252R|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000599812.1_Silent_p.R345R|PSG5_ENST00000342951.6_Silent_p.R252R			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	252	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TTTCTCCTGAACGGTAATAGG	0.478000													29	276					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156381735	156381735	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:156381735C>A	ENST00000274532.2	-	2	147	c.91G>T	c.(91-93)Gtt>Ttt	p.V31F	TIMD4_ENST00000407087.3_Missense_Mutation_p.V31F	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	31	Ig-like V-type.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGACCCAAAACCTCCGTCACA	0.493000													6	53					1.26484e-09	2.01203e-09	1	1	0
CEP128	145508	broad.mit.edu	37	14	80971335	80971335	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:80971335T>C	ENST00000555265.1	-	24	3476	c.3101A>G	c.(3100-3102)cAc>cGc	p.H1034R	CEP128_ENST00000553717.1_5'UTR|CEP128_ENST00000281129.3_Missense_Mutation_p.H1034R			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	1034						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CCCACGAGTGTGGGAACCTTC	0.428000													9	37					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20874769	20874769	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:20874769G>T	ENST00000381552.1	+	8	1175	c.807G>T	c.(805-807)caG>caT	p.Q269H	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.Q269H|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.Q220H|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.Q151H|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.Q269H			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	269					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					AAGATCCCCAGTGGGTAGGAG	0.403000													12	54					4.3838e-07	5.96081e-07	1	1	0
FRMPD3	84443	broad.mit.edu	37	X	106840727	106840727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:106840727C>T	ENST00000276185.4	+	15	1717	c.1717C>T	c.(1717-1719)Cag>Tag	p.Q573*				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	573						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						AAGGAAGGAGCAGGAAAGCCG	0.572000													5	58					0	0	1	0	0
METTL21C	196541	broad.mit.edu	37	13	103338651	103338651	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:103338651G>T	ENST00000267273.6	-	4	530	c.525C>A	c.(523-525)gaC>gaA	p.D175E		NM_001010977.1	NP_001010977.1	Q5VZV1	MT21C_HUMAN	methyltransferase like 21C	175							methyltransferase activity			breast(1)|large_intestine(3)|lung(2)|skin(1)	7						TTTTGTCCAGGTCTTCCCCCC	0.443000													10	48					0.000673444	0.000753965	1	1	0
NLRP3	114548	broad.mit.edu	37	1	247588376	247588376	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:247588376C>A	ENST00000366497.2	+	4	2411	c.1631C>A	c.(1630-1632)aCg>aAg	p.T544K	NLRP3_ENST00000391828.3_Missense_Mutation_p.T544K|NLRP3_ENST00000348069.2_Missense_Mutation_p.T544K|NLRP3_ENST00000366496.2_Missense_Mutation_p.T544K|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.T544K|NLRP3_ENST00000391827.2_Missense_Mutation_p.T544K	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	544					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.T544M(1)		NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GAAGGAAGGACGAACGTTCCA	0.473000													11	52					0.00829132	0.00898953	1	1	0
UNC79	57578	broad.mit.edu	37	14	94046715	94046715	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:94046715G>A	ENST00000553484.1	+	19	2808	c.2654G>A	c.(2653-2655)cGg>cAg	p.R885Q	UNC79_ENST00000555664.1_Missense_Mutation_p.R885Q|UNC79_ENST00000393151.2_Missense_Mutation_p.R885Q|UNC79_ENST00000256339.4_Missense_Mutation_p.R708Q			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	885						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GAAGAAAGCCGGCTGGTGGTA	0.443000													10	42					0	0	1	0	0
DTD1	92675	broad.mit.edu	37	20	18724844	18724844	+	Missense_Mutation	SNP	G	G	T	rs146358079		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:18724844G>T	ENST00000377452.3	+	5	758	c.578G>T	c.(577-579)cGc>cTc	p.R193L		NM_080820.4	NP_543010.3	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	193					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			large_intestine(4)|lung(1)|ovary(2)	7						AAAGAAGACCGCAGTGCCAGC	0.532000													4	44					0.00909568	0.00973356	1	1	0
IL36RN	26525	broad.mit.edu	37	2	113819740	113819740	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:113819740C>A	ENST00000393200.2	+	4	316	c.155C>A	c.(154-156)gCc>gAc	p.A52D	IL36RN_ENST00000346807.3_Missense_Mutation_p.A52D	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	52						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGGCTGGATGCCAGCCTGTCC	0.617000													5	39					0.184627	0.186437	1	1	0
ZNF76	7629	broad.mit.edu	37	6	35258421	35258421	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:35258421C>T	ENST00000373953.3	+	7	819	c.553C>T	c.(553-555)Cat>Tat	p.H185Y	ZNF76_ENST00000339411.5_Missense_Mutation_p.H185Y|ZNF76_ENST00000440666.2_Missense_Mutation_p.H159Y	NM_003427.3	NP_003418.2	P36508	ZNF76_HUMAN	zinc finger protein 76	185					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CTCACAGGTGCATGAACGAGC	0.517000													20	114					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48157811	48157811	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:48157811C>T	ENST00000418331.2	+	9	2188	c.1836C>T	c.(1834-1836)caC>caT	p.H612H		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	612	Fibronectin type-III 6.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						AAGTGGACCACGTCTGGGGGG	0.517000													9	135					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145246248	145246248	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:145246248T>C	ENST00000377976.1	-	2	379	c.380A>G	c.(379-381)aAt>aGt	p.N127S		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	127										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						TTTCAGGTTATTAGTGTAGAT	0.403000													24	85					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6367540	6367540	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:6367540C>T	ENST00000262483.8	-	16	2193	c.2106G>A	c.(2104-2106)ccG>ccA	p.P702P	ACKR6_ENST00000421306.3_Silent_p.P666P|ACKR6_ENST00000576664.1_5'UTR	NM_031220.3	NP_112497.2																					GCCGGGGCCGCGGCACATTGT	0.577000													7	91					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423904	190423904	+	Translation_Start_Site	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:190423904A>G	ENST00000534846.1	-	2	199	c.2T>C	c.(1-3)aTg>aCg	p.M1T	FAM5C_ENST00000367462.3_Silent_p.H39H|FAM5C_ENST00000484105.1_5'UTR			Q76B58	FAM5C_HUMAN		0						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGCTTGTGGCATGCTGATCCG	0.517000													17	55					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80677634	80677634	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:80677634C>A	ENST00000557010.1	-	3	567	c.182G>T	c.(181-183)cGc>cTc	p.R61L	DIO2_ENST00000422005.3_Missense_Mutation_p.R61L|DIO2_ENST00000555750.1_Missense_Mutation_p.R61L|DIO2_ENST00000557125.1_Intron|DIO2_ENST00000438257.4_Missense_Mutation_p.R61L	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	61					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCAGACGCAGCGCAGTCCCTC	0.597000													5	32					0.014758	0.0155109	1	1	0
OR10K2	391107	broad.mit.edu	37	1	158390364	158390364	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:158390364G>T	ENST00000314902.2	-	1	292	c.293C>A	c.(292-294)gCc>gAc	p.A98D		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CATTTGGATGGCACAGCCCAG	0.488000													38	126					1.42033e-22	2.85452e-22	1	1	0
ERCC6L	54821	broad.mit.edu	37	X	71427655	71427655	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:71427655A>G	ENST00000373657.1	-	3	1195	c.593T>C	c.(592-594)aTa>aCa	p.I198T	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Missense_Mutation_p.I321T			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	321	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					ATAGGGTTTTATGATTGCCAT	0.388000													39	51					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110814772	110814772	+	Missense_Mutation	SNP	C	C	A	rs113994113		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:110814772C>A	ENST00000375820.4	-	48	4388	c.4267G>T	c.(4267-4269)Ggt>Tgt	p.G1423C	COL4A1_ENST00000467182.1_5'UTR	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1423	Triple-helical region.		G -> R (in PCEPH).		angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGGTGGACCTGGAAATCCT	0.493000													20	82					1.33834e-09	2.11262e-09	1	1	0
SOX8	30812	broad.mit.edu	37	16	1035113	1035113	+	Silent	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:1035113C>G	ENST00000293894.3	+	3	1183	c.1068C>G	c.(1066-1068)ccC>ccG	p.P356P		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	356					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				GAGGCTCGCCCGACTACGGTT	0.761000													6	9					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21042519	21042519	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:21042519C>G	ENST00000261383.3	-	37	5286	c.5287G>C	c.(5287-5289)Gtg>Ctg	p.V1763L	DNAH3_ENST00000415178.1_Missense_Mutation_p.V1763L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1763	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCGTGGCTCACTTGGTCAAAG	0.512000													30	73					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10560358	10560358	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:10560358C>A	ENST00000309384.1	-	4	552	c.371G>T	c.(370-372)tGg>tTg	p.W124L	KLRC4-KLRK1_ENST00000539300.1_Silent_p.V115V	NM_013431.2	NP_038459.1	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C, member 4	124					cellular defense response	integral to membrane	binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						ATATGTAATCCACTCCTCAGG	0.333000													24	157					3.6726e-16	6.90919e-16	1	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885612	88885612	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:88885612C>A	ENST00000319675.3	-	1	684	c.588G>T	c.(586-588)gcG>gcT	p.A196A		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	196										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AAGAGTGATACGCGTGGATGC	0.557000													17	105					1.99824e-07	2.76266e-07	1	1	0
DMBX1	127343	broad.mit.edu	37	1	46976223	46976223	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:46976223A>T	ENST00000371956.4	+	2	260	c.245A>T	c.(244-246)cAg>cTg	p.Q82L	DMBX1_ENST00000360032.3_Missense_Mutation_p.Q77L	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	82	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					ACGGCTCAGCAGCTCGAGGCC	0.592000													9	41					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934842	30934842	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:30934842C>A	ENST00000355537.3	+	2	520	c.373C>A	c.(373-375)Cgc>Agc	p.R125S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGACGACGCCCGCAAGAACCG	0.627000													11	25					7.03913e-09	1.07016e-08	1	1	0
TPTE	7179	broad.mit.edu	37	21	10942973	10942973	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr21:10942973A>T	ENST00000298232.7	-	11	927	c.560T>A	c.(559-561)aTt>aAt	p.I187N	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.I167N|TPTE_ENST00000361285.4_Missense_Mutation_p.I205N	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	205					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGATGAAAAATTCTTAACAG	0.294000													7	89					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487825	248487825	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:248487825C>A	ENST00000317965.2	-	1	74	c.46G>T	c.(46-48)Gga>Tga	p.G16*		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGAAGATTCCCAGGAGGAGG	0.458000													31	244					1.90571e-15	3.53672e-15	1	1	0
SPAG6	9576	broad.mit.edu	37	10	22675740	22675740	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:22675740A>G	ENST00000376603.2	+	5	900	c.758A>G	c.(757-759)cAg>cGg	p.Q253R	SPAG6_ENST00000376601.1_Intron|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000538630.1_Missense_Mutation_p.Q152R|SPAG6_ENST00000313311.6_Missense_Mutation_p.Q177R|SPAG6_ENST00000376624.3_Missense_Mutation_p.Q177R			O75602	SPAG6_HUMAN	sperm associated antigen 6	177					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						CTCTGTATCCAGGAGCCAGAA	0.463000													23	61					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5754237	5754237	+	Missense_Mutation	SNP	G	G	A	rs150053328	by1000genomes	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:5754237G>A	ENST00000381624.3	+	13	1320	c.1259G>A	c.(1258-1260)gGc>gAc	p.G420D	CATSPERD_ENST00000381614.2_Missense_Mutation_p.G78D|CATSPERD_ENST00000309164.7_3'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	420						integral to membrane											CCCCAGCCAGGCACATCCCTG	0.463000													31	107					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76387895	76387895	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:76387895G>C	ENST00000284142.6	-	2	690	c.551C>G	c.(550-552)aCa>aGa	p.T184R		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	184					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						GAGTACTATTGTTAAGACAAT	0.363000													5	39					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401463	77401463	+	Missense_Mutation	SNP	G	G	T	rs141796905	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:77401463G>T	ENST00000282849.5	-	4	1071	c.653C>A	c.(652-654)cCc>cAc	p.P218H	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	218					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G216_G219del(1)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GCCAGAGCCGGGGTAGCCACG	0.552000													27	76					6.36457e-07	8.54138e-07	1	1	0
ADCY7	113	broad.mit.edu	37	16	50344760	50344760	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:50344760G>T	ENST00000394697.2	+	19	2663	c.2323G>T	c.(2323-2325)Ggc>Tgc	p.G775C	ADCY7_ENST00000254235.3_Missense_Mutation_p.G775C			P51828	ADCY7_HUMAN	adenylate cyclase 7	775					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCAAGGCCTGGGCAACCTCAC	0.667000													6	11					3.59834e-05	4.42542e-05	1	1	0
XPO4	64328	broad.mit.edu	37	13	21442842	21442842	+	Splice_Site	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:21442842T>A	ENST00000400602.2	-	2	105		c.e2-2		XPO4_ENST00000490513.1_Splice_Site|XPO4_ENST00000255305.6_Splice_Site	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4						protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AGGTGGTGCCTTGAGAGTTAA	0.358000													22	82					0	0	1	0	0
GRAP	10750	broad.mit.edu	37	17	18925292	18925292	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:18925292C>A	ENST00000284154.5	-	5	1344	c.634G>T	c.(634-636)Gtg>Ttg	p.V212L	SLC5A10_ENST00000317977.6_3'UTR|GRAP_ENST00000395635.1_Missense_Mutation_p.V183L|GRAP_ENST00000573099.1_Silent_p.T155T	NM_006613.3	NP_006604.1	Q13588	GRAP_HUMAN	GRB2-related adaptor protein	212	SH3 2.				cell-cell signaling|Ras protein signal transduction	cytoplasm	SH3/SH2 adaptor activity			large_intestine(1)|urinary_tract(1)	2	all_cancers(12;0.0183)					ACGGGCTGCACGTAACTCCGT	0.667000													4	6					0.184627	0.186437	1	1	0
POTEE	445582	broad.mit.edu	37	2	132021714	132021714	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:132021714C>A	ENST00000356920.5	+	15	2780	c.2686C>A	c.(2686-2688)Cgt>Agt	p.R896S	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	896	Actin-like.						ATP binding										CCTCACCGAGCGTGGCTATAG	0.592000													18	145					1.37657e-19	2.71361e-19	1	1	0
CEACAM18	729767	broad.mit.edu	37	19	51983815	51983815	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:51983815T>G	ENST00000396477.4	+	2	302	c.281T>G	c.(280-282)gTg>gGg	p.V94G	CEACAM18_ENST00000451626.1_Missense_Mutation_p.V155G	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	155						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGGGAGAGAGTGAACAGAGAA	0.552000													5	69					0	0	1	0	0
PEX12	5193	broad.mit.edu	37	17	33904285	33904285	+	Missense_Mutation	SNP	C	C	T	rs150186509	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:33904285C>T	ENST00000225873.4	-	2	1059	c.452G>A	c.(451-453)cGc>cAc	p.R151H		NM_000286.2	NP_000277.1	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	151					protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(8)	18				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCGTTTCCAGCGGGAAGAAGG	0.458000													9	116					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95499298	95499298	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:95499298C>T	ENST00000324972.6	+	6	722	c.529C>T	c.(529-531)Cat>Tat	p.H177Y	DYNC1I1_ENST00000447467.2_Missense_Mutation_p.H160Y|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.H140Y|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.H140Y|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.H160Y|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.H157Y	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	177					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTTGCCACGCATCAGTCTGA	0.448000													14	51					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714742	28714742	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:28714742G>T	ENST00000257197.3	-	12	1930	c.1669C>A	c.(1669-1671)Cga>Aga	p.R557R	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.R557R	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	557	Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GTGCAAGATCGGCCAACTAAG	0.318000													5	30					0.000602214	0.000681627	1	1	0
BRSK1	84446	broad.mit.edu	37	19	55816220	55816220	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:55816220G>T	ENST00000309383.1	+	14	1926	c.1649G>T	c.(1648-1650)aGg>aTg	p.R550M	BRSK1_ENST00000588584.1_3'UTR|BRSK1_ENST00000326848.7_Missense_Mutation_p.R245M|BRSK1_ENST00000590333.1_Missense_Mutation_p.R566M	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	550					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCGCCTGGAGGAGTCGTCTC	0.682000													4	20					1.024e-07	1.44979e-07	1	1	0
USH2A	7399	broad.mit.edu	37	1	216246234	216246234	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:216246234C>T	ENST00000366943.2	-	29	6240	c.5854G>A	c.(5854-5856)Gca>Aca	p.A1952T	USH2A_ENST00000307340.3_Missense_Mutation_p.A1952T|RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000430890.1_RNA|RP11-22M7.2_ENST00000446411.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1952					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATTTACCTGCTCCTGTTGTA	0.388000										HNSCC(13;0.011)			25	96					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176895872	176895872	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:176895872C>A	ENST00000292385.5	-	3	730	c.121G>T	c.(121-123)Gat>Tat	p.D41Y	DBN1_ENST00000309007.5_Missense_Mutation_p.D39Y|DBN1_ENST00000393565.1_Missense_Mutation_p.D39Y	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	39	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGAGGTCATCGGAGCCATCT	0.607000													22	147					4.06085e-26	8.32373e-26	1	1	0
ANK2	287	broad.mit.edu	37	4	114179244	114179244	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:114179244C>A	ENST00000357077.4	+	12	1280	c.1227C>A	c.(1225-1227)aaC>aaA	p.N409K	ANK2_ENST00000264366.6_Missense_Mutation_p.N409K|ANK2_ENST00000506722.1_Missense_Mutation_p.N388K|ANK2_ENST00000394537.3_Missense_Mutation_p.N409K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	409					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCAAGAAAAACCGCATCAAAG	0.398000													5	49					1.23904e-05	1.55636e-05	1	1	0
SETD2	29072	broad.mit.edu	37	3	47098519	47098519	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:47098519G>C	ENST00000409792.3	-	15	6797	c.6755C>G	c.(6754-6756)tCc>tGc	p.S2252C		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2252	Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGCAACGCTGGAGTCTTGGTG	0.557000			"""N, F, S, Mis"""		clear cell renal carcinoma								10	58					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52323841	52323841	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:52323841C>A	ENST00000356297.4	-	16	2131	c.2031G>T	c.(2029-2031)aaG>aaT	p.K677N	PXDNL_ENST00000543296.1_Missense_Mutation_p.K677N	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	677					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGAGCCCCTGCTTCACACGTT	0.512000													3	13					0.115264	0.117838	1	1	0
RB1CC1	9821	broad.mit.edu	37	8	53554950	53554950	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:53554950C>A	ENST00000025008.5	-	18	4821	c.4298G>T	c.(4297-4299)aGa>aTa	p.R1433I	RB1CC1_ENST00000435644.2_Missense_Mutation_p.R1433I|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Missense_Mutation_p.R1433I	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1433					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TGAATCCACTCTTCCTTCATC	0.438000													9	87					3.09899e-07	4.2418e-07	1	1	0
NKX2-5	1482	broad.mit.edu	37	5	172659698	172659698	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:172659698C>A	ENST00000329198.4	-	2	1122	c.849G>T	c.(847-849)ccG>ccT	p.P283P		NM_001166175.1|NM_001166176.1|NM_004387.3	NP_001159647.1|NP_001159648.1|NP_004378.1	P52952	NKX25_HUMAN	NK2 homeobox 5	283					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)	12	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CGGCAGTGGCCGGCTGCGCTG	0.672000													3	23					6.4e-05	7.73255e-05	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2021562	2021562	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:2021562G>T	ENST00000262113.4	+	10	1243	c.1102G>T	c.(1102-1104)Gcc>Tcc	p.A368S	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	368	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGACCACAGCGCCTTCCTGTT	0.677000													7	22					5.18039e-06	6.66975e-06	1	1	0
KCNH7	90134	broad.mit.edu	37	2	163253386	163253386	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:163253386C>G	ENST00000332142.5	-	11	2576	c.2477G>C	c.(2476-2478)aGa>aCa	p.R826T		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	826					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGTGAGGGCTCTTACATCTGC	0.363000													10	65					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	281643	281643	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:281643G>A	ENST00000534750.1	+	4	2114	c.1909G>A	c.(1909-1911)Gcc>Acc	p.A637T	NLRP6_ENST00000312165.5_Missense_Mutation_p.A637T	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	637						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGTGCGCCAAGCCCTGTGCCG	0.642000													12	112					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685794	248685794	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:248685794C>A	ENST00000343414.4	+	1	879	c.847C>A	c.(847-849)Cca>Aca	p.P283T		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATAGTCACCCCACTTTTAAA	0.438000													14	93					1.52009e-12	2.65372e-12	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168104562	168104562	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:168104562C>A	ENST00000409195.1	+	9	6749	c.6660C>A	c.(6658-6660)tcC>tcA	p.S2220S	XIRP2_ENST00000295237.9_Silent_p.S2220S|XIRP2_ENST00000409273.1_Silent_p.S1998S|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2045					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGACACATCCAATGTAACAG	0.348000													7	48					0.000274275	0.000313893	1	1	0
TRO	7216	broad.mit.edu	37	X	54956056	54956056	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:54956056G>T	ENST00000173898.7	+	12	3011	c.2899G>T	c.(2899-2901)Gct>Tct	p.A967S	TRO_ENST00000375041.2_Missense_Mutation_p.A570S|TRO_ENST00000319167.8_Intron|TRO_ENST00000399736.1_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.A498S|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	967	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CAGCACTGGTGCTGGCTTTGG	0.532000													9	17					0.00621372	0.00675475	1	1	0
RAB40AL	282808	broad.mit.edu	37	X	102192261	102192261	+	Silent	SNP	C	C	T	rs5945909	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:102192261C>T	ENST00000218249.5	+	1	62	c.15C>T	c.(13-15)ggC>ggT	p.G5G		NM_001031834.1	NP_001027004.1	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	5					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(3)	12						GCGCCCCGGGCAGCCCCGACC	0.657000													5	46					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31309743	31309743	+	Translation_Start_Site	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:31309743A>G	ENST00000380490.3	+	1	99	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	1					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		TGAAGCAAACATGGATCAAGA	0.522000													4	40					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115336424	115336424	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:115336424C>T	ENST00000337530.6	+	2	360	c.64C>T	c.(64-66)Cat>Tat	p.H22Y	KIAA1958_ENST00000374244.3_Missense_Mutation_p.H22Y|KIAA1958_ENST00000536272.1_Missense_Mutation_p.H22Y	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	22										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						GGCCCATAGCCATGGGACTAT	0.488000													20	55					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45459726	45459726	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:45459726G>T	ENST00000371438.1	+	5	1092	c.734G>T	c.(733-735)cGc>cTc	p.R245L	RUNX2_ENST00000541979.1_Missense_Mutation_p.R313L|RUNX2_ENST00000352853.5_Missense_Mutation_p.R313L|RUNX2_ENST00000465038.2_Missense_Mutation_p.R245L|RUNX2_ENST00000359524.5_Missense_Mutation_p.R231L|RUNX2_ENST00000371436.6_Missense_Mutation_p.R245L|RUNX2_ENST00000576263.1_Missense_Mutation_p.R245L|RUNX2_ENST00000371432.3_Missense_Mutation_p.R231L	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	245	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TTCTCTGACCGCCTCAGTGAT	0.448000													48	150					5.82388e-19	1.13718e-18	1	1	0
PCDHB5	26167	broad.mit.edu	37	5	140516658	140516658	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:140516658G>T	ENST00000231134.5	+	1	1859	c.1642G>T	c.(1642-1644)Gtg>Ttg	p.V548L		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		548	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGTGCGCGTGCTGGTGCT	0.716000													12	88					0.00010058	0.000119766	1	1	0
FLG	2312	broad.mit.edu	37	1	152279008	152279008	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:152279008G>T	ENST00000368799.1	-	3	8389	c.8354C>A	c.(8353-8355)aCc>aAc	p.T2785N	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2785	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCACGAATGGTGTCCTGACC	0.602000									Ichthyosis				103	986					3.20846e-33	6.60944e-33	1	1	0
OR3A4P	390756	broad.mit.edu	37	17	3214165	3214165	+	RNA	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:3214165C>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TCCCACAGCCCTTCCAGCTCT	0.522000													29	163					2.65835e-16	5.04718e-16	1	1	0
CSF2RA	1438	broad.mit.edu	37	X	1409278	1409278	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:1409278C>A	ENST00000381524.3	+	7	708	c.522C>A	c.(520-522)acC>acA	p.T174T	CSF2RA_ENST00000355805.2_Silent_p.T174T|CSF2RA_ENST00000381500.1_Silent_p.T174T|CSF2RA_ENST00000432318.2_Silent_p.T174T|CSF2RA_ENST00000381529.3_Silent_p.T174T|CSF2RA_ENST00000355432.3_Silent_p.T174T|CSF2RA_ENST00000501036.2_Silent_p.T41T|CSF2RA_ENST00000361536.3_Silent_p.T174T|CSF2RA_ENST00000381509.3_Silent_p.T174T|CSF2RA_ENST00000417535.2_Silent_p.T174T			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	174						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTCAGGAACCCATGTGGGAT	0.433000													46	172					3.77016e-25	7.65175e-25	1	1	0
DICER1	23405	broad.mit.edu	37	14	95570375	95570375	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:95570375T>G	ENST00000526495.1	-	23	3649	c.3358A>C	c.(3358-3360)Aat>Cat	p.N1120H	DICER1_ENST00000393063.1_Missense_Mutation_p.N1120H|DICER1_ENST00000556045.1_Missense_Mutation_p.N18H|DICER1_ENST00000541352.1_Missense_Mutation_p.N1120H|DICER1_ENST00000343455.3_Missense_Mutation_p.N1120H|DICER1_ENST00000527414.1_Missense_Mutation_p.N1120H			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1120					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTACAGTAATTATCATTTTCA	0.383000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				11	40					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14722178	14722178	+	Splice_Site	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:14722178T>G	ENST00000403951.2	-	12	1454	c.1035_splice	c.e12+1	p.T345_splice	DGKB_ENST00000407950.1_Splice_Site_p.T338_splice|DGKB_ENST00000406247.3_Splice_Site_p.T345_splice|DGKB_ENST00000402815.1_Splice_Site_p.T345_splice|DGKB_ENST00000399322.3_Splice_Site_p.T345_splice|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Splice_Site_p.T345_splice|DGKB_ENST00000444700.2_Splice_Site_p.T338_splice			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	345					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TTTTACTCACTGTGATCTGAC	0.443000													19	94					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52141253	52141253	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:52141253C>A	ENST00000596288.1	-	9	1349	c.1322G>T	c.(1321-1323)gGg>gTg	p.G441V	MCM3_ENST00000229854.7_Missense_Mutation_p.G396V|MCM3_ENST00000476448.1_5'UTR|MCM3_ENST00000419835.2_Missense_Mutation_p.G350V	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	396	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GACCATGGCCCCTGCTTCCAG	0.512000													7	31					1.06961e-07	1.49891e-07	1	1	0
PROC	5624	broad.mit.edu	37	2	128184758	128184758	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:128184758C>A	ENST00000453608.2	+	7	929	c.921C>A	c.(919-921)gcC>gcA	p.A307A	PROC_ENST00000422777.3_Silent_p.A252A|PROC_ENST00000234071.3_Silent_p.A252A|PROC_ENST00000409048.1_Silent_p.A286A			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	252	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	TGACAGCGGCCCACTGCATGG	0.632000													24	83					4.16121e-05	5.07225e-05	1	1	0
MRPS9	64965	broad.mit.edu	37	2	105705441	105705441	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:105705441G>T	ENST00000258455.3	+	6	599		c.e6-1			NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9						DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						GTTTGCCATAGGATGTATATG	0.323000													9	42					0.000274275	0.000313893	1	1	0
COMMD10	51397	broad.mit.edu	37	5	115469782	115469782	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:115469782G>T	ENST00000274458.4	+	5	479	c.417G>T	c.(415-417)tgG>tgT	p.W139C	COMMD10_ENST00000515539.1_Missense_Mutation_p.W125C	NM_016144.2	NP_057228.1	Q9Y6G5	COMDA_HUMAN	COMM domain containing 10	139	COMM.						protein binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(2)	9		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)		CCGTTGGATGGCAGCTTAACC	0.423000													9	45					4.68919e-08	6.85087e-08	1	1	0
OAS2	4939	broad.mit.edu	37	12	113424976	113424976	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:113424976A>T	ENST00000392583.2	+	2	518	c.311A>T	c.(310-312)aAg>aTg	p.K104M	OAS2_ENST00000342315.4_Missense_Mutation_p.K104M|OAS2_ENST00000449768.2_Missense_Mutation_p.K104M|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	104	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ACTGGGGATAAGCTGAAGTTC	0.443000													23	89					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56952761	56952761	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:56952761C>A	ENST00000504904.3	-	7	2322	c.1603G>T	c.(1603-1605)Gcc>Tcc	p.A535S	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000292069.6_Missense_Mutation_p.A535S|ZNF667_ENST00000342634.3_Missense_Mutation_p.A663S			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TGACTAAAGGCCTTACCACAT	0.453000													18	74					0.000566183	0.000644385	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113299408	113299408	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:113299408G>T	ENST00000297405.5	-	58	9460	c.9216C>A	c.(9214-9216)ttC>ttA	p.F3072L	CSMD3_ENST00000352409.3_Missense_Mutation_p.F3002L|CSMD3_ENST00000455883.2_Missense_Mutation_p.F2903L|CSMD3_ENST00000343508.3_Missense_Mutation_p.F3032L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3072	Sushi 22.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTTAGTTCTGAAATTGCTTT	0.458000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	94					1	1	1	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262141	39262141	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:39262141C>A	ENST00000391415.1	+	1	558	c.501C>A	c.(499-501)tcC>tcA	p.S167S		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	167	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						gctgtgaatccagctgctgcc	0.662000													5	15					0.014758	0.0155109	1	1	0
CCDC144A	9720	broad.mit.edu	37	17	16612467	16612467	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:16612467G>T	ENST00000443444.2	+	5	1236	c.1096G>T	c.(1096-1098)Gaa>Taa	p.E366*	CCDC144A_ENST00000456009.1_Intron|RP11-219A15.1_ENST00000448331.3_Nonsense_Mutation_p.E366*|CCDC144A_ENST00000360524.8_Nonsense_Mutation_p.E366*|CCDC144A_ENST00000340621.5_Nonsense_Mutation_p.E365*|CCDC144A_ENST00000399273.1_Nonsense_Mutation_p.E366*			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	366																	TGAACAAAAAGAACCCAGTCT	0.368000													9	54					9.70103e-10	1.54916e-09	1	1	0
MYO1D	4642	broad.mit.edu	37	17	31039046	31039046	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:31039046C>A	ENST00000318217.5	-	16	2385	c.2081G>T	c.(2080-2082)cGt>cTt	p.R694L	MYO1D_ENST00000579584.1_Missense_Mutation_p.R694L|MYO1D_ENST00000394649.4_Missense_Mutation_p.R606L	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	694						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CATCTGGGCACGGAGTTCTTC	0.333000													39	118					2.91434e-09	4.51393e-09	1	1	0
GLB1L3	112937	broad.mit.edu	37	11	134182324	134182324	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:134182324T>A	ENST00000431683.2	+	14	1369	c.1369T>A	c.(1369-1371)Tat>Aat	p.Y457N		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	457					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GCTTGTCCTGTATGAGAAGTC	0.587000													11	48					0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144709601	144709601	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:144709601C>A	ENST00000409214.1	-	11	1519	c.1241G>T	c.(1240-1242)aGg>aTg	p.R414M	GTDC1_ENST00000392867.3_Missense_Mutation_p.R329M|AC016910.1_ENST00000422799.1_RNA|GTDC1_ENST00000409298.1_Missense_Mutation_p.R296M|GTDC1_ENST00000241391.5_Missense_Mutation_p.R329M|GTDC1_ENST00000542155.1_Missense_Mutation_p.R414M|GTDC1_ENST00000392869.1_Missense_Mutation_p.R414M|GTDC1_ENST00000344850.4_Missense_Mutation_p.R414M|GTDC1_ENST00000463875.2_Missense_Mutation_p.R285M	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	414					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		ATTCTGGAGCCTTTTTGAAAG	0.328000													14	56					1.99824e-07	2.76266e-07	1	1	0
FSCN1	6624	broad.mit.edu	37	7	5643183	5643183	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:5643183C>T	ENST00000382361.3	+	3	1160	c.1046C>T	c.(1045-1047)gCg>gTg	p.A349V	FSCN1_ENST00000340250.6_Missense_Mutation_p.A328V	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	349					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		ACACTGAGGGCGTCCAATGGC	0.617000													10	83					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976865	119976865	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:119976865G>C	ENST00000313400.4	-	3	887	c.787C>G	c.(787-789)Cag>Gag	p.Q263E	ASTN2_ENST00000373996.3_Missense_Mutation_p.Q263E|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.Q263E			O75129	ASTN2_HUMAN	astrotactin 2	263						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCCCGCGCCTGGGGACCCAGC	0.602000													13	41					0	0	1	0	0
HNRNPKP3	399881	broad.mit.edu	37	11	43284737	43284737	+	RNA	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:43284737T>A	ENST00000511537.1	-	0	198					NR_033868.1																						TTGGGGCCATTGCCCTCTGGG	0.433000													3	13					0	0	1	0	0
ASNS	440	broad.mit.edu	37	7	97484706	97484706	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:97484706C>T	ENST00000175506.4	-	10	1624	c.1096G>A	c.(1096-1098)Gga>Aga	p.G366R	ASNS_ENST00000394308.3_Missense_Mutation_p.G366R|ASNS_ENST00000455086.1_Missense_Mutation_p.G283R|ASNS_ENST00000394309.3_Missense_Mutation_p.G366R|ASNS_ENST00000422745.1_Missense_Mutation_p.G345R|ASNS_ENST00000437628.1_Missense_Mutation_p.G283R|ASNS_ENST00000444334.1_Missense_Mutation_p.G345R	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	366	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCATCTGATCCTTCTCCAGAG	0.343000													7	68					0	0	1	0	0
ADAM17	6868	broad.mit.edu	37	2	9630407	9630407	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:9630407A>G	ENST00000310823.3	-	19	2556	c.2374T>C	c.(2374-2376)Ttt>Ctt	p.F792L	IAH1_ENST00000545602.1_Intron	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	792					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		AGATCCTCAAATGACTTGGCA	0.507000													7	41					0	0	1	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58021458	58021458	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:58021458T>A	ENST00000341156.4	-	10	1911	c.1327A>T	c.(1327-1329)Act>Tct	p.T443S	B4GALNT1_ENST00000418555.2_Missense_Mutation_p.T388S	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	443					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			ACCTTGTCAGTCCGCGCCAGG	0.692000													3	26					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30863445	30863445	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:30863445T>G	ENST00000395805.2	-	17	3198	c.2651A>C	c.(2650-2652)aAc>aCc	p.N884T	CAPRIN2_ENST00000417045.1_Missense_Mutation_p.N939T|CAPRIN2_ENST00000298892.5_Intron|CAPRIN2_ENST00000308433.5_Intron|CAPRIN2_ENST00000251071.5_Intron	NM_001206856.1	NP_001193785.1	Q6IMN6	CAPR2_HUMAN	caprin family member 2	0					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AATGAAGCAGTTAGCTTTGAA	0.348000													18	93					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42340064	42340064	+	Missense_Mutation	SNP	G	G	T	rs55786369		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:42340064G>T	ENST00000262418.6	-	3	201	c.46C>A	c.(46-48)Ctg>Atg	p.L16M	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	16					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCCTGCTCCAGATTCTCCTCC	0.587000													5	55					0.000602214	0.000681627	1	1	0
DRP2	1821	broad.mit.edu	37	X	100494017	100494017	+	Silent	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:100494017G>C	ENST00000395209.3	+	6	1013	c.486G>C	c.(484-486)gtG>gtC	p.V162V	DRP2_ENST00000402866.1_Silent_p.V162V|DRP2_ENST00000541709.1_Silent_p.V84V|DRP2_ENST00000538510.1_Silent_p.V162V	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	162					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TCTATTCTGTGCTGGAGTCAG	0.458000													19	41					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71512772	71512772	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:71512772G>T	ENST00000370924.4	-	1	719	c.489C>A	c.(487-489)caC>caA	p.H163Q	PTGER3_ENST00000460330.1_Missense_Mutation_p.H163Q|PTGER3_ENST00000306666.5_Missense_Mutation_p.H163Q|PTGER3_ENST00000356595.4_Missense_Mutation_p.H163Q|PTGER3_ENST00000351052.5_Missense_Mutation_p.H163Q|PTGER3_ENST00000354608.5_Missense_Mutation_p.H163Q|PTGER3_ENST00000414819.1_Missense_Mutation_p.H163Q|PTGER3_ENST00000370932.2_Missense_Mutation_p.H163Q|PTGER3_ENST00000370931.3_Missense_Mutation_p.H163Q	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	163					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	TCGCATACCAGTGCGGCGCCC	0.682000													6	25					0.00116845	0.00130461	1	1	0
FGA	2243	broad.mit.edu	37	4	155505708	155505708	+	Silent	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:155505708A>T	ENST00000302053.3	-	6	2247	c.2169T>A	c.(2167-2169)gtT>gtA	p.V723V		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	723	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CAACCCTAAGAACAGAGCCCC	0.507000													18	131					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16067786	16067786	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:16067786G>T	ENST00000332432.8	-	4	1202	c.1003C>A	c.(1003-1005)Cgg>Agg	p.R335R		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	335						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						GACTCTCCCCGGCTGCTTTCT	0.483000													24	56					1.96895e-08	2.90755e-08	1	1	0
OR6T1	219874	broad.mit.edu	37	11	123814000	123814000	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:123814000C>A	ENST00000321252.2	-	1	580	c.546G>T	c.(544-546)tgG>tgT	p.W182C		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGAGCAAGGGCCAACTGTCAC	0.562000													8	83					0.00307968	0.00339259	1	1	0
KLRC4-KLRK1	100528032	broad.mit.edu	37	12	10560360	10560360	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:10560360C>A	ENST00000539300.1	-	4	342	c.343G>T	c.(343-345)Gtg>Ttg	p.V115L	KLRC4_ENST00000309384.1_Missense_Mutation_p.E123D																							ATGTAATCCACTCCTCAGGAC	0.338000													24	155					3.6726e-16	6.90919e-16	1	1	0
MS4A2	2206	broad.mit.edu	37	11	59860293	59860293	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:59860293T>A	ENST00000278888.3	+	4	452	c.350T>A	c.(349-351)aTa>aAa	p.I117K		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	117					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	TTGTCAATTATATCTGAAAGG	0.353000													11	31					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900545	51900545	+	Silent	SNP	A	A	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:51900545A>C	ENST00000268919.4	+	1	307	c.151A>C	c.(151-153)Aga>Cga	p.R51R		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	51					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGAGATCAACAGAGAAAACTA	0.522000													11	101					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132452	15132452	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:15132452C>T	ENST00000292574.3	+	5	1148	c.1066C>T	c.(1066-1068)Ctg>Ttg	p.L356L		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	356					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						GACGTTAGGACTGATGAGGGG	0.587000													17	53					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81635341	81635341	+	Splice_Site	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:81635341C>A	ENST00000429644.2	-	10	1880	c.1236_splice	c.e10-1	p.D413_splice	GBE1_ENST00000489715.1_Splice_Site_p.D372_splice	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	413					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CCTGATACATCCTACAACAAA	0.403000									Glycogen Storage Disease, type IV				5	68					0.014758	0.0155109	1	1	0
NELL1	4745	broad.mit.edu	37	11	21392415	21392415	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:21392415C>A	ENST00000298925.5	+	16	1803	c.1650C>A	c.(1648-1650)ggC>ggA	p.G550G	NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000357134.5_Silent_p.G522G|NELL1_ENST00000325319.5_Silent_p.G465G|NELL1_ENST00000532434.1_Silent_p.G522G			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	522	EGF-like 5; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						GTGAAGAGGGCTGCAGATACG	0.428000													3	18					0.115264	0.117838	1	1	0
FBXL14	144699	broad.mit.edu	37	12	1703114	1703114	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:1703114T>A	ENST00000339235.3	-	1	217	c.119A>T	c.(118-120)tAc>tTc	p.Y40F	WNT5B_ENST00000537031.1_Intron	NM_152441.2	NP_689654.1	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	40	F-box.|Required for down-regulation of SNAI1.					cytoplasm				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	8	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			CGACTTGTGGTAGGCGGCGTC	0.731000													3	8					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151358099	151358099	+	Splice_Site	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:151358099A>G	ENST00000367321.3	+	26	2968		c.e26-1			NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like						folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		CCTTTCTCACAGGGTTTTGGA	0.438000													20	46					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27238832	27238832	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:27238832T>G	ENST00000222753.4	-	1	893	c.865A>C	c.(865-867)Atg>Ctg	p.M289L	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	289					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GGGCAGTACATTTGGCCGTTC	0.662000			T	NUP98	AML								8	39					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23520465	23520465	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:23520465G>A	ENST00000374619.1	-	1	757	c.248C>T	c.(247-249)aCc>aTc	p.T83I	HTR1D_ENST00000314113.3_Missense_Mutation_p.T83I	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	83					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity			NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CAAGAGGTCGGTGGTGGCCAG	0.542000													40	169					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135553	156135553	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:156135553C>T	ENST00000329476.3	+	2	951	c.462C>T	c.(460-462)taC>taT	p.Y154Y	NPY2R_ENST00000506608.1_Silent_p.Y154Y	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	154					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				GCATCGTCTACCACCTAGAGA	0.577000													12	39					0	0	1	0	0
CCDC134	79879	broad.mit.edu	37	22	42204967	42204967	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:42204967A>T	ENST00000255784.5	+	2	177	c.73A>T	c.(73-75)Agg>Tgg	p.R25W	CCDC134_ENST00000402061.3_Missense_Mutation_p.R25W	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	25						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						AGGCACCTTGAGGACCTCCCT	0.483000													10	66					0	0	1	0	0
DUSP15	128853	broad.mit.edu	37	20	30451725	30451725	+	Missense_Mutation	SNP	T	T	A	rs148987141	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:30451725T>A	ENST00000278979.3	-	5	315	c.239A>T	c.(238-240)aAc>aTc	p.N80I	DUSP15_ENST00000486996.1_5'UTR|DUSP15_ENST00000375966.4_Missense_Mutation_p.N80I|DUSP15_ENST00000398083.1_5'UTR|DUSP15_ENST00000339738.5_Missense_Mutation_p.N83I|DUSP15_ENST00000493115.1_5'UTR|DUSP15_ENST00000398084.2_5'UTR			Q9H1R2	DUS15_HUMAN	dual specificity phosphatase 15	80	Tyrosine-protein phosphatase.					cytoplasm|plasma membrane	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)|lung(4)|pancreas(1)|stomach(1)	7			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CACAAGGCAGTTCCCCCCATT	0.547000													10	79					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736238	140736238	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:140736238C>T	ENST00000571252.1	+	1	1471	c.1471C>T	c.(1471-1473)Ctg>Ttg	p.L491L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTTACTCCCTGGCCGAAGA	0.502000													17	179					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14537800	14537800	+	Splice_Site	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:14537800C>G	ENST00000358970.5	-	3	809	c.810_splice	c.e3+1	p.K270_splice	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	270										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AGATCTATACCTTGTTTTTTG	0.358000													6	46					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6185606	6185606	+	Silent	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:6185606T>A	ENST00000588304.1	+	11	1778	c.1332T>A	c.(1330-1332)tcT>tcA	p.S444S	ACSBG2_ENST00000252669.5_Silent_p.S494S|ACSBG2_ENST00000588485.1_Silent_p.S307S|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000591403.1_Silent_p.S494S|ACSBG2_ENST00000586696.1_Silent_p.S494S			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	494					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity	p.S494S(1)		breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGCTACACTCTGGGGATCTGG	0.557000													30	135					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89390960	89390960	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:89390960C>T	ENST00000336596.2	+	5	1251	c.1026C>T	c.(1024-1026)atC>atT	p.I342I	EPHA3_ENST00000494014.1_Silent_p.I342I|EPHA3_ENST00000452448.2_Silent_p.I342I	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	342	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCTCAGTTATCCTGGACTGGA	0.413000										TSP Lung(6;0.00050)			5	81					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28514451	28514451	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:28514451G>A	ENST00000261609.7	-	11	1497	c.1389C>T	c.(1387-1389)ttC>ttT	p.F463F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	463					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACAGAATCAGGAAACGCTTCT	0.532000													5	33					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20566665	20566665	+	Silent	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:20566665A>G	ENST00000329697.6	-	4	690	c.522T>C	c.(520-522)tgT>tgC	p.C174C	ACSM2B_ENST00000567001.1_Silent_p.C174C|ACSM2B_ENST00000414188.2_Silent_p.C174C|ACSM2B_ENST00000565322.1_Silent_p.C95C|ACSM2B_ENST00000565232.1_Silent_p.C174C	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	174					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCAGAGAAGGACATTCAGATG	0.448000													24	280					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906434	13906434	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:13906434C>A	ENST00000279593.3	-	3	1036	c.827G>T	c.(826-828)gGg>gTg	p.G276V		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	276					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGAGATGAGCCCAGTGGGGAA	0.552000													18	70					1.99824e-07	2.76266e-07	1	1	0
CHAT	1103	broad.mit.edu	37	10	50863282	50863282	+	Splice_Site	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:50863282A>T	ENST00000395562.2	+	13	1999	c.1530_splice	c.e13+1	p.P510_splice	CHAT_ENST00000337653.2_Splice_Site_p.P592_splice|CHAT_ENST00000351556.3_Splice_Site_p.P474_splice|CHAT_ENST00000339797.1_Splice_Site_p.P474_splice|CHAT_ENST00000455728.2_Splice_Site_p.P474_splice|CHAT_ENST00000395559.2_Splice_Site_p.P474_splice	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	592					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CTGCTGTGCCAGTAAGTCCCG	0.627000													8	73					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55591088	55591088	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:55591088C>A	ENST00000373965.2	-	31	4604	c.4210G>T	c.(4210-4212)Gtc>Ttc	p.V1404F	PCDH15_ENST00000437009.1_Missense_Mutation_p.V1326F|PCDH15_ENST00000395430.1_Missense_Mutation_p.V1397F|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.V1397F|PCDH15_ENST00000395433.1_Missense_Mutation_p.V1375F|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000409834.1_Missense_Mutation_p.V1008F|PCDH15_ENST00000395438.1_Missense_Mutation_p.V1397F|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.V1404F|PCDH15_ENST00000414778.1_Missense_Mutation_p.V1402F|PCDH15_ENST00000395432.2_Missense_Mutation_p.V1360F|PCDH15_ENST00000320301.6_Missense_Mutation_p.V1397F	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1397					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGTAGCTGACCAAAACCACC	0.448000										HNSCC(58;0.16)			23	91					6.44725e-10	1.04167e-09	1	1	0
TNFRSF8	943	broad.mit.edu	37	1	12175698	12175698	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:12175698C>A	ENST00000263932.2	+	8	1080	c.858C>A	c.(856-858)ggC>ggA	p.G286G	TNFRSF8_ENST00000417814.2_Silent_p.G175G	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	286					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GTCGACCTGGCATGATCTGTG	0.572000													13	96					0.000151284	0.000178594	1	1	0
ANKHD1	54882	broad.mit.edu	37	5	139889704	139889704	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:139889704G>T	ENST00000297183.6	+	22	4166	c.4042G>T	c.(4042-4044)Ggt>Tgt	p.G1348C	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.G1348C|ANKHD1_ENST00000360839.2_Missense_Mutation_p.G1348C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGCAAGCAGGTGCTGATGT	0.453000													20	72					1.33834e-09	2.11262e-09	1	1	0
PPP2R2B	5521	broad.mit.edu	37	5	146030285	146030285	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:146030285C>A	ENST00000394413.3	-	5	1020	c.450G>T	c.(448-450)gtG>gtT	p.V150V	PPP2R2B_ENST00000394411.4_Silent_p.V150V|PPP2R2B_ENST00000394410.2_Silent_p.V139V|PPP2R2B_ENST00000504198.1_Silent_p.V156V|PPP2R2B_ENST00000508545.2_Silent_p.V139V|PPP2R2B_ENST00000453001.1_Silent_p.V150V|PPP2R2B_ENST00000394409.3_Silent_p.V208V|PPP2R2B_ENST00000356826.3_Silent_p.V150V|PPP2R2B_ENST00000394414.1_Silent_p.V216V|PPP2R2B_ENST00000336640.6_Silent_p.V153V|PPP2R2B_ENST00000530902.1_5'UTR			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	150					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAGGACAGGCACCTGGGATG	0.438000													16	37					2.62699e-14	4.72628e-14	1	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18195010	18195010	+	Silent	SNP	C	C	A	rs143611694		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:18195010C>A	ENST00000314254.3	+	1	627	c.207C>A	c.(205-207)gcC>gcA	p.A69A	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	69						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TCAACCTGGCCGCAGCAGACT	0.522000													18	118					6.94344e-10	1.11746e-09	1	1	0
TMTC1	83857	broad.mit.edu	37	12	29786150	29786150	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:29786150C>T	ENST00000256062.5	-	6	1207	c.734G>A	c.(733-735)cGg>cAg	p.R245Q	TMTC1_ENST00000319685.8_5'UTR|TMTC1_ENST00000552618.1_Missense_Mutation_p.R415Q|TMTC1_ENST00000539277.1_Missense_Mutation_p.R353Q|TMTC1_ENST00000551659.1_Missense_Mutation_p.R415Q|TMTC1_ENST00000381224.2_Missense_Mutation_p.R307Q	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	353						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGCTAAGTTCCGCATGTCCCA	0.498000													20	94					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95552634	95552634	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:95552634G>T	ENST00000371418.4	+	6	898	c.638G>T	c.(637-639)aGt>aTt	p.S213I	LGI1_ENST00000371413.3_Missense_Mutation_p.S213I|LGI1_ENST00000542308.1_Missense_Mutation_p.S165I	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	213	LRRCT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				AAAATCAATAGTCTCTCCTCG	0.403000													14	128					9.31168e-06	1.18774e-05	1	1	0
RTTN	25914	broad.mit.edu	37	18	67698116	67698116	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:67698116C>T	ENST00000255674.6	-	41	5929	c.5643G>A	c.(5641-5643)ttG>ttA	p.L1881L	RTTN_ENST00000454359.1_3'UTR|RTTN_ENST00000579986.1_5'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1881							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				GCTCACCTTTCAAAGCATGTT	0.383000													14	55					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106717429	106717429	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:106717429G>T	ENST00000546625.1	+	6	936	c.777G>T	c.(775-777)gaG>gaT	p.E259D	TCP11L2_ENST00000552690.1_Intron|TCP11L2_ENST00000299045.3_Intron|TCP11L2_ENST00000547153.1_Intron			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	0										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						CTCCAAGTGAGTATAATATAA	0.254000													11	53					3.86212e-05	4.72164e-05	1	1	0
RIMS2	9699	broad.mit.edu	37	8	104898089	104898089	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:104898089C>A	ENST00000507740.1	+	2	922	c.686C>A	c.(685-687)cCa>cAa	p.P229Q	RIMS2_ENST00000436393.2_Missense_Mutation_p.P199Q|RIMS2_ENST00000406091.3_Missense_Mutation_p.P421Q|RIMS2_ENST00000262231.10_Missense_Mutation_p.P229Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	452					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCTCAGGGACCAAGTTCTTAT	0.473000										HNSCC(12;0.0054)			8	50					0.00307968	0.00339259	1	1	0
LDB2	9079	broad.mit.edu	37	4	16597468	16597468	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:16597468A>T	ENST00000502640.1	-	3	414	c.266T>A	c.(265-267)tTt>tAt	p.F89Y	LDB2_ENST00000503178.2_5'UTR|LDB2_ENST00000304523.5_Missense_Mutation_p.F89Y|LDB2_ENST00000503829.1_5'UTR|LDB2_ENST00000515064.1_Missense_Mutation_p.F89Y|LDB2_ENST00000441778.2_Missense_Mutation_p.F89Y			O43679	LDB2_HUMAN	LIM domain binding 2	89							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CACAGTGCTAAAGTAACGGGG	0.493000													8	34					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39027459	39027459	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:39027459G>A	ENST00000379907.4	+	10	985	c.858G>A	c.(856-858)ttG>ttA	p.L286L	ADAM32_ENST00000519315.1_Silent_p.L286L|ADAM32_ENST00000437682.2_Silent_p.L293L	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	286	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CTCGTTATTTGGGAGCAGTGT	0.259000													5	39					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10783774	10783774	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:10783774C>A	ENST00000075503.3	-	5	841	c.321G>T	c.(319-321)caG>caT	p.Q107H		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	107						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CCCGCGGCACCTGCAGCTTAG	0.547000										HNSCC(73;0.22)			25	91					2.44723e-14	4.42219e-14	1	1	0
TCERG1L	256536	broad.mit.edu	37	10	132965132	132965132	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:132965132C>A	ENST00000368642.4	-	5	958	c.873G>T	c.(871-873)cgG>cgT	p.R291R		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	291										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCACTCGGCCCCGCTCTGTCC	0.522000													4	20					0.150653	0.153637	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155157673	155157673	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:155157673C>T	ENST00000357232.3	-	25	6765	c.6766G>A	c.(6766-6768)Gga>Aga	p.G2256R		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2256	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TAAAAATGTCCCTTCTCATTT	0.398000													10	109					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327305	57327305	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:57327305G>A	ENST00000326441.9	-	10	2868	c.2505C>T	c.(2503-2505)atC>atT	p.I835I	PEG3_ENST00000423103.2_Silent_p.I835I|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000598410.1_Silent_p.I711I|PEG3_ENST00000593695.1_Silent_p.I709I|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	835					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTAAGCTATGGATAACAGACC	0.443000													26	103					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55816221	55816221	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:55816221G>T	ENST00000309383.1	+	14	1927	c.1650G>T	c.(1648-1650)agG>agT	p.R550S	BRSK1_ENST00000588584.1_3'UTR|BRSK1_ENST00000326848.7_Missense_Mutation_p.R245S|BRSK1_ENST00000590333.1_Missense_Mutation_p.R566S	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	550					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCGCCTGGAGGAGTCGTCTCA	0.687000													4	20					1.024e-07	1.44979e-07	1	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79088945	79088945	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:79088945G>T	ENST00000388820.4	-	4	1016	c.806C>A	c.(805-807)aCc>aAc	p.T269N	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	269	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GTTCATGATGGTCAGCACATA	0.597000													36	171					2.6416e-12	4.53475e-12	1	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24909340	24909340	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:24909340G>A	ENST00000396432.2	-	9	1970	c.1484C>T	c.(1483-1485)tCa>tTa	p.S495L	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.S282L	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	494					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						ATAATCCCATGAACGAGTTCT	0.393000													13	86					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618968	7618968	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:7618968C>A	ENST00000256861.6	-	10	1504	c.1426G>T	c.(1426-1428)Gat>Tat	p.D476Y	ITIH5_ENST00000397146.2_Missense_Mutation_p.D476Y|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Missense_Mutation_p.D476Y|ITIH5_ENST00000298441.6_Missense_Mutation_p.D262Y|ITIH5_ENST00000446830.2_Missense_Mutation_p.D258Y	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	476	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CTGATTTCATCGTAGAACCTG	0.582000													4	40					0.0215528	0.0223671	1	1	0
SIGLEC5	8778	broad.mit.edu	37	19	52132748	52132748	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:52132748A>G	ENST00000222107.4	-	3	701	c.563T>C	c.(562-564)cTg>cCg	p.L188P	SIGLEC5_ENST00000534261.2_Missense_Mutation_p.L188P|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.L188P|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.L188P|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.L188P			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	188	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTCGGGGTCCAGGGGGCTGAG	0.657000													4	30					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203332400	203332400	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:203332400A>T	ENST00000374580.4	+	3	945	c.406A>T	c.(406-408)Aca>Tca	p.T136S	BMPR2_ENST00000374574.2_Missense_Mutation_p.T136S|BMPR2_ENST00000479069.1_3'UTR	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	136					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						ACCTCCTGACACAACACCACT	0.343000													12	60					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783871	54783871	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:54783871G>T	ENST00000391748.1	-	4	257	c.130C>A	c.(130-132)Ccc>Acc	p.P44T	LILRB2_ENST00000434421.1_Intron|LILRB2_ENST00000391746.1_Missense_Mutation_p.P44T|LILRB2_ENST00000471216.1_5'UTR|LILRB2_ENST00000314446.5_Missense_Mutation_p.P44T|LILRB2_ENST00000391749.4_Missense_Mutation_p.P44T	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	44	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGGGTGACGGGACTCCCCTGG	0.532000													24	170					1.1804e-14	2.17109e-14	1	1	0
PCDHB12	56124	broad.mit.edu	37	5	140589401	140589401	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:140589401G>T	ENST00000239450.2	+	1	1111	c.922G>T	c.(922-924)Gat>Tat	p.D308Y	PCDHB12_ENST00000541609.1_5'UTR	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		308	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACCTTTGGATTTTGAAGC	0.373000													35	104					2.42023e-17	4.65951e-17	1	1	0
RBM43	375287	broad.mit.edu	37	2	152108172	152108172	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:152108172T>A	ENST00000331426.5	-	4	473	c.322A>T	c.(322-324)Agc>Tgc	p.S108C		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	108							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTTACAGAGCTGAAGATCTGA	0.348000													19	55					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20180570	20180570	+	Nonstop_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:20180570T>C	ENST00000400331.5	-	7	2866	c.2558A>G	c.(2557-2559)tAg>tGg	p.*853W	MACC1_ENST00000332878.4_Nonstop_Mutation_p.*853W|MACC1_ENST00000589011.1_Nonstop_Mutation_p.*853W	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	0					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GCTTTGTTTCTATACTTCCTC	0.413000													30	130					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84442394	84442394	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:84442394G>C	ENST00000286744.5	+	4	533	c.309G>C	c.(307-309)ttG>ttC	p.L103F	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.L103F	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	103	TSP type-1 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAGATGTTTGACTGGAAGGT	0.522000													7	32					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677689	37677689	+	Silent	SNP	C	C	T	rs144159375		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:37677689C>T	ENST00000532828.2	-	5	1001	c.750G>A	c.(748-750)gcG>gcA	p.A250A	ZNF585B_ENST00000531805.1_Silent_p.A195A|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000312908.5_5'UTR	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTGTGTGAACGCTTTGCCAC	0.433000													10	137					0	0	1	0	0
ASB11	140456	broad.mit.edu	37	X	15301712	15301712	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:15301712C>A	ENST00000537676.1	-	7	896	c.824G>T	c.(823-825)cGg>cTg	p.R275L	ASB11_ENST00000344384.4_Missense_Mutation_p.R275L|ASB11_ENST00000480796.1_Missense_Mutation_p.R296L|ASB11_ENST00000380470.3_Missense_Mutation_p.R279L			Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box containing 11	296	SOCS box.				intracellular signal transduction					breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(1)	16	Hepatocellular(33;0.183)					GAGACACTTCCGGACACACAG	0.527000													42	59					1.59361e-14	2.90516e-14	1	1	0
ANKRD10	55608	broad.mit.edu	37	13	111545442	111545442	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:111545442C>A	ENST00000267339.2	-	4	758	c.624G>T	c.(622-624)gtG>gtT	p.V208V	ANKRD10_ENST00000310847.4_3'UTR|ANKRD10_ENST00000375758.5_3'UTR|ANKRD10_ENST00000489973.2_5'UTR	NM_017664.2	NP_060134.2	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	208										central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)	9	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			GATTTGTTCCCACACTAATAT	0.413000													15	112					2.32078e-09	3.6356e-09	1	1	0
PTCHD2	57540	broad.mit.edu	37	1	11562886	11562886	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:11562886G>A	ENST00000294484.6	+	3	1386	c.1248G>A	c.(1246-1248)gaG>gaA	p.E416E	PTCHD2_ENST00000389575.3_Silent_p.E416E	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	416					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		ACCGCTGGGAGGAACAACGGG	0.562000													8	50					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20471548	20471548	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:20471548C>A	ENST00000573854.1	+	2	226	c.112C>A	c.(112-114)Cag>Aag	p.Q38K	ACSM2A_ENST00000417235.2_Intron|ACSM2A_ENST00000424070.1_Missense_Mutation_p.Q38K|ACSM2A_ENST00000396104.2_Missense_Mutation_p.Q38K|ACSM2A_ENST00000575558.1_Intron|ACSM2A_ENST00000575690.1_Missense_Mutation_p.Q38K|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.Q38K	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	38					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GTGGGGCCACCAGGAAGTGCC	0.522000													9	39					0.000274275	0.000313893	1	1	0
TERF2IP	54386	broad.mit.edu	37	16	75690287	75690287	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:75690287C>T	ENST00000300086.4	+	3	1075	c.978C>T	c.(976-978)aaC>aaT	p.N326N		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	326					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						AGAAGTTTAACTTGGATCTAT	0.453000													12	247					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30873266	30873266	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:30873266A>G	ENST00000383096.3	-	12	1215	c.1033T>C	c.(1033-1035)Tat>Cat	p.Y345H	CCDC178_ENST00000300227.8_Missense_Mutation_p.Y345H|CCDC178_ENST00000403303.1_Missense_Mutation_p.Y345H|CCDC178_ENST00000583930.1_Missense_Mutation_p.Y345H|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000406524.2_Missense_Mutation_p.Y345H|CCDC178_ENST00000402325.1_Missense_Mutation_p.Y345H|CCDC178_ENST00000579947.1_Missense_Mutation_p.Y345H					coiled-coil domain containing 178																		TTAAGTTGATATATCTCTCTC	0.318000													9	41					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8288498	8288498	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:8288498G>T	ENST00000307358.2	+	3	900	c.696G>T	c.(694-696)aaG>aaT	p.K232N	HTRA3_ENST00000382512.3_Missense_Mutation_p.K232N	NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	232	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						CCACCATCAAGATCCATCCCA	0.622000													8	34					0.00307968	0.00339259	1	1	0
BACH2	60468	broad.mit.edu	37	6	90718437	90718437	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:90718437C>T	ENST00000257749.4	-	6	834	c.127G>A	c.(127-129)Gtg>Atg	p.V43M	BACH2_ENST00000537989.1_Missense_Mutation_p.V43M|BACH2_ENST00000343122.3_Missense_Mutation_p.V43M	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	43	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TTCCTCTCCACGATCAAAGTC	0.527000													7	107					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20785024	20785024	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:20785024C>G	ENST00000404938.2	+	26	4044	c.3392C>G	c.(3391-3393)gCa>gGa	p.A1131G	ABCB5_ENST00000258738.6_Missense_Mutation_p.A686G	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	686					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GCCGCAAATGCAGCAAATATC	0.438000													6	87					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103010991	103010991	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:103010991G>T	ENST00000409599.1	+	11	1530	c.1174G>T	c.(1174-1176)Gag>Tag	p.E392*	IL18R1_ENST00000233957.1_Nonsense_Mutation_p.E392*			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	392	TIR.				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						AAATGGAGAGGAGCACACCTT	0.403000													6	46					0.0293803	0.0303376	1	1	0
IFIT1B	439996	broad.mit.edu	37	10	91144408	91144408	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:91144408C>A	ENST00000371809.3	+	2	1418	c.1338C>A	c.(1336-1338)atC>atA	p.I446I	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	446							binding			endometrium(2)|large_intestine(3)|lung(8)	13						TTGGGCTTATCCACAAATTGA	0.438000													22	191					2.21704e-12	3.82183e-12	1	1	0
HECW1	23072	broad.mit.edu	37	7	43581470	43581470	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:43581470C>A	ENST00000395891.1	+	26	4726	c.4121C>A	c.(4120-4122)cCc>cAc	p.P1374H	HECW1_ENST00000453890.1_Missense_Mutation_p.P1340H	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1374	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TCACCCAGGCCCTGTGATTTG	0.433000													9	71					5.68852e-11	9.56601e-11	1	1	0
KCNH8	131096	broad.mit.edu	37	3	19574939	19574939	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:19574939T>A	ENST00000328405.2	+	16	2938	c.2672T>A	c.(2671-2673)gTg>gAg	p.V891E		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	891						integral to membrane	two-component sensor activity	p.V891E(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						ATGAGAAATGTGATCCAGCTT	0.458000													10	79					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753878	76753878	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:76753878G>A	ENST00000536229.3	+	1	2197	c.1488G>A	c.(1486-1488)acG>acA	p.T496T	SALL3_ENST00000575389.2_Silent_p.T629T|SALL3_ENST00000537592.2_Silent_p.T629T			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	629					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCGCACCCACGAGCCTCGGCA	0.711000													4	8					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394593	233394593	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:233394593C>T	ENST00000258229.8	-	5	1249	c.1015G>A	c.(1015-1017)Ggg>Agg	p.G339R	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	339						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCAGGTCCCCCTGGCAGGAG	0.567000													35	116					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110644530	110644530	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:110644530G>A	ENST00000338081.3	-	3	807	c.636C>T	c.(634-636)aaC>aaT	p.N212N	DCX_ENST00000356915.2_Silent_p.N131N|DCX_ENST00000356220.3_Silent_p.N131N|DCX_ENST00000496551.1_5'UTR|DCX_ENST00000488120.1_Silent_p.N131N|DCX_ENST00000371993.2_Silent_p.N131N	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	212	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						TTTTAAAGAAGTTGTCTGAGG	0.388000													18	92					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139429123	139429123	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:139429123G>C	ENST00000272641.3	-	2	270	c.164C>G	c.(163-165)cCc>cGc	p.P55R		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	55	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CAGGCGCAGGGGACTGATGAT	0.572000													11	115					0	0	1	0	0
NARS2	79731	broad.mit.edu	37	11	78204213	78204213	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:78204213G>C	ENST00000281038.5	-	7	1093	c.718C>G	c.(718-720)Ccg>Gcg	p.P240A	NARS2_ENST00000528850.1_Missense_Mutation_p.P13A	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	240					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CGGAAGGTCGGACCAAAGGTA	0.363000													5	69					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55399467	55399467	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:55399467C>A	ENST00000355524.3	+	4	465	c.455C>A	c.(454-456)cCa>cAa	p.P152Q	FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000345937.4_Intron|FCAR_ENST00000391723.3_Missense_Mutation_p.P140Q|FCAR_ENST00000391724.3_Missense_Mutation_p.P140Q|FCAR_ENST00000391725.3_Missense_Mutation_p.P152Q|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000359272.4_Missense_Mutation_p.P140Q|FCAR_ENST00000353758.4_Missense_Mutation_p.P43Q|FCAR_ENST00000469767.1_Missense_Mutation_p.P152Q	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	152	Ig-like C2-type 2.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		GCACACATCCCATTTGATAGA	0.527000													15	42					2.32078e-09	3.6356e-09	1	1	0
SLAMF7	57823	broad.mit.edu	37	1	160721186	160721186	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:160721186T>C	ENST00000368043.3	+	5	858	c.821T>C	c.(820-822)aTa>aCa	p.I274T	SLAMF7_ENST00000458104.2_Intron|SLAMF7_ENST00000359331.4_Intron|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000441662.2_Missense_Mutation_p.I143T|SLAMF7_ENST00000458602.2_Missense_Mutation_p.I127T|SLAMF7_ENST00000368042.3_Missense_Mutation_p.I167T	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	274					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ACTCCTAACATATGCCCCCAT	0.468000													61	177					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227513	38227513	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:38227513G>T	ENST00000373048.4	-	3	413	c.414C>A	c.(412-414)ggC>ggA	p.G138G	EPHA10_ENST00000427468.2_Silent_p.G138G|EPHA10_ENST00000319637.6_Silent_p.G138G	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	138						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GACGCCCACGGCCCAGGTCGG	0.657000													19	71					2.94398e-08	4.33186e-08	1	1	0
RAX	30062	broad.mit.edu	37	18	56936405	56936405	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:56936405G>T	ENST00000334889.3	-	3	1058	c.872C>A	c.(871-873)cCc>cAc	p.P291H	RAX_ENST00000256852.7_3'UTR	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	291					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		TTGCAGGCCGGGGCCCAACGG	0.766000													3	6					0.004672	0.00510574	1	1	0
HIST1H1T	3010	broad.mit.edu	37	6	26108009	26108009	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:26108009C>A	ENST00000338379.4	-	1	355	c.313G>T	c.(313-315)Gct>Tct	p.A105S		NM_005323.3	NP_005314.2	P22492	H1T_HUMAN	histone cluster 1, H1t	105	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			breast(2)|endometrium(1)|lung(3)|ovary(2)|prostate(1)	9						GAACCGGAAGCACCAGTACCC	0.468000													28	87					4.7796e-09	7.34775e-09	1	1	0
AXL	558	broad.mit.edu	37	19	41758860	41758860	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:41758860G>A	ENST00000301178.4	+	16	2104	c.1914G>A	c.(1912-1914)ggG>ggA	p.G638G	AXL_ENST00000593513.1_Silent_p.G370G|AXL_ENST00000359092.3_Silent_p.G629G	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	638	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CCCGGCTCGGGGACCAGCCAG	0.517000													8	108					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871727	51871727	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:51871727C>A	ENST00000371497.5	+	2	2617	c.1730C>A	c.(1729-1731)cCc>cAc	p.P577H	TSHZ2_ENST00000329613.6_Missense_Mutation_p.P574H|TSHZ2_ENST00000603338.2_Missense_Mutation_p.P574H	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	577					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAGCTGAGGCCCATTGCACCA	0.537000													20	97					8.10497e-08	1.15946e-07	1	1	0
EIF1	10209	broad.mit.edu	37	17	39846059	39846059	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:39846059G>T	ENST00000469257.1	+	2	207	c.61G>T	c.(61-63)Gac>Tac	p.D21Y	EIF1_ENST00000591776.1_Missense_Mutation_p.D21Y|JUP_ENST00000540235.1_Intron|EIF1_ENST00000310837.4_Intron			P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1	21					regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|skin(1)	5		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TAAGGGTGATGACCTGCTTCC	0.478000											OREG0024409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	61					0.000673444	0.000753965	1	1	0
AKR1D1	6718	broad.mit.edu	37	7	137790167	137790167	+	Missense_Mutation	SNP	A	A	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:137790167A>C	ENST00000242375.3	+	5	613	c.571A>C	c.(571-573)Agc>Cgc	p.S191R	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000432161.1_Missense_Mutation_p.S191R|AKR1D1_ENST00000411726.2_Intron	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	191					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						CAAGCCAGTCAGCAACCAGGT	0.532000													38	139					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74701813	74701813	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:74701813C>T	ENST00000370895.1	+	4	406	c.371C>T	c.(370-372)tCa>tTa	p.S124L	FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.S124L|TNNI3K_ENST00000370893.1_Missense_Mutation_p.S124L|TNNI3K_ENST00000370891.2_Missense_Mutation_p.S124L|TNNI3K_ENST00000326637.3_Missense_Mutation_p.S23L|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.S124L			Q59H18	TNI3K_HUMAN		23						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										GTCAGTGAATCATATGTTATC	0.313000													12	62					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583739	47583739	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:47583739C>A	ENST00000172229.3	+	3	412	c.287C>A	c.(286-288)tCg>tAg	p.S96*	RP5-1029K10.2_ENST00000514506.1_RNA|NGFR_ENST00000504201.1_Nonsense_Mutation_p.S2*	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	96					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CAGAGCATGTCGGCGCCGTGC	0.701000													13	33					1.61879e-10	2.71115e-10	1	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256892	140256892	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:140256892A>T	ENST00000398631.2	+	1	1835	c.1835A>T	c.(1834-1836)cAa>cTa	p.Q612L	PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACGAGTTGCAACCGGCGGCG	0.677000													18	115					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6648079	6648079	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:6648079C>A	ENST00000299441.3	-	14	6602	c.6191G>T	c.(6190-6192)cGt>cTt	p.R2064L		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2064	Cadherin 19.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCGGGGTCCACGCTCAGCTTC	0.592000													6	26					0.0215528	0.0223671	1	1	0
PRPS2	5634	broad.mit.edu	37	X	12817467	12817467	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:12817467G>T	ENST00000380668.5	+	2	392	c.264G>T	c.(262-264)gtG>gtT	p.V88V	PRPS2_ENST00000398491.2_Silent_p.V88V|PRPS2_ENST00000489404.1_Silent_p.V88V	NM_001039091.2|NM_002765.4	NP_001034180.1|NP_002756.1	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	88					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TAACTGCCGTGATCCCGTGTT	0.502000													28	55					1.38854e-25	2.83207e-25	1	1	0
SLC33A1	9197	broad.mit.edu	37	3	155571391	155571391	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:155571391G>A	ENST00000392845.2	-	1	776	c.396C>T	c.(394-396)gtC>gtT	p.V132V	SLC33A1_ENST00000359479.3_Silent_p.V132V	NM_004733.3	NP_004724.1	O00400	ACATN_HUMAN	solute carrier family 33 (acetyl-CoA transporter), member 1	132					cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	22			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTTAACGTAGACCGCATCAA	0.448000													11	68					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470922	111470922	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:111470922C>T	ENST00000265162.5	+	17	2723	c.2381C>T	c.(2380-2382)tCt>tTt	p.S794F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	794					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATGCAGAACTCTGGCAATGAG	0.393000													22	71					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5536432	5536432	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:5536432G>T	ENST00000380184.1	-	1	1503	c.1240C>A	c.(1240-1242)Ctc>Atc	p.L414I	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	414										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GACAGCTGGAGATCACCCTTT	0.483000													21	105					9.95505e-16	1.86431e-15	1	1	0
HSP90AB2P	391634	broad.mit.edu	37	4	13339345	13339345	+	RNA	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:13339345C>A	ENST00000602906.1	+	0	862																				kidney(3)|lung(1)	4						GCCTTGAGCTCTTCACTGAGC	0.418000													10	17					1.58986e-06	2.08606e-06	1	1	0
ALDH3B2	222	broad.mit.edu	37	11	67431212	67431212	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:67431212C>A	ENST00000349015.3	-	9	1332	c.894G>T	c.(892-894)gaG>gaT	p.E298D	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.E298D	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	298					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TGCTGGTCCGCTCCAGCATCT	0.597000													9	26					7.48243e-07	9.94439e-07	1	1	0
CCAR1	55749	broad.mit.edu	37	10	70549551	70549551	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:70549551G>T	ENST00000265872.6	+	24	3391	c.3272G>T	c.(3271-3273)aGt>aTt	p.S1091I	CCAR1_ENST00000543719.1_Missense_Mutation_p.S1076I|CCAR1_ENST00000535016.1_Missense_Mutation_p.S1076I	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	1091					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						AAGGACCTTAGTCAGTTACAA	0.303000													5	53					3.59834e-05	4.42542e-05	1	1	0
ZNF479	90827	broad.mit.edu	37	7	57188356	57188356	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:57188356G>T	ENST00000331162.4	-	5	1036	c.766C>A	c.(766-768)Ctt>Att	p.L256I		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGTCTAGTAAGGTTTGCAGAC	0.428000													21	49					8.10497e-08	1.15946e-07	1	1	0
ATP6V1C1	528	broad.mit.edu	37	8	104054571	104054571	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:104054571G>T	ENST00000395862.3	+	3	295	c.136G>T	c.(136-138)Ggc>Tgc	p.G46C	ATP6V1C1_ENST00000521514.1_5'UTR|ATP6V1C1_ENST00000518738.1_Missense_Mutation_p.G46C|ATP6V1C1_ENST00000518857.1_Intron	NM_001695.4	NP_001686.1	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	46					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			CTTTTAGGTTGGCACGTTGGA	0.343000													9	79					2.80697e-09	4.36405e-09	1	1	0
CT47B1	643311	broad.mit.edu	37	X	120008979	120008979	+	Silent	SNP	T	T	C	rs871733	by1000genomes	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:120008979T>C	ENST00000371311.3	-	1	800	c.546A>G	c.(544-546)ccA>ccG	p.P182P		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	182										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CCTCGCCTTCTGGGGCTGCAG	0.711000													4	57					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106209346	106209346	+	RNA	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:106209346G>T	ENST00000390548.2	-	0	62																											GGGCTGCTGTGCCCCCAGAGG	0.672000													8	28					0.000274275	0.000313893	1	1	0
GPBAR1	151306	broad.mit.edu	37	2	219127845	219127845	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:219127845C>A	ENST00000522678.1	+	2	1266	c.398C>A	c.(397-399)gCt>gAt	p.A133D	GPBAR1_ENST00000521462.1_Missense_Mutation_p.A133D|GPBAR1_ENST00000519574.1_Missense_Mutation_p.A133D|GPBAR1_ENST00000479077.1_Missense_Mutation_p.A133D	NM_001077191.1	NP_001070659.1	Q8TDU6	GPBAR_HUMAN	G protein-coupled bile acid receptor 1	133						integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(1)|ovary(1)	4		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCACCTGGGCTGGTCCCCTG	0.662000													16	40					3.41278e-10	5.55757e-10	1	1	0
MYH1	4619	broad.mit.edu	37	17	10408826	10408826	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:10408826T>C	ENST00000226207.5	-	20	2271	c.2177A>G	c.(2176-2178)tAc>tGc	p.Y726C	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	726	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TAACACCTTGTATCTGTTTAA	0.433000													18	58					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487826	248487826	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:248487826C>A	ENST00000317965.2	-	1	73	c.45G>T	c.(43-45)ctG>ctT	p.L15L		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAAGATTCCCAGGAGGAGGA	0.458000													31	240					1.90571e-15	3.53672e-15	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140166919	140166919	+	Silent	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:140166919A>G	ENST00000504120.2	+	1	1044	c.1044A>G	c.(1042-1044)ccA>ccG	p.P348P	PCDHA1_ENST00000394633.3_Silent_p.P348P|PCDHA1_ENST00000378133.3_Silent_p.P348P	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATGCTCCAGAACTGGCGG	0.478000													35	72					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175365732	175365732	+	Silent	SNP	G	G	A	rs138698493	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:175365732G>A	ENST00000367674.1	-	5	1896	c.1188C>T	c.(1186-1188)taC>taT	p.Y396Y	TNR_ENST00000263525.2_Silent_p.Y396Y	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	396	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TAATGACAGCGTAGACGCTGA	0.572000													5	77					0	0	1	0	0
LDHA	3939	broad.mit.edu	37	11	18424492	18424492	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:18424492G>T	ENST00000422447.3	+	5	797	c.524G>T	c.(523-525)gGg>gTg	p.G175V	LDHA_ENST00000540430.1_Missense_Mutation_p.G204V|LDHA_ENST00000396222.2_Missense_Mutation_p.G175V|LDHA_ENST00000379412.5_Missense_Mutation_p.G175V|LDHA_ENST00000430553.2_Missense_Mutation_p.G117V|LDHA_ENST00000227157.4_Missense_Mutation_p.G175V|LDHA_ENST00000542179.1_Missense_Mutation_p.G175V	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	175					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	TACCTAATGGGGGAAAGGCTG	0.453000													6	46					5.50884e-06	7.07053e-06	1	1	0
PDCD11	22984	broad.mit.edu	37	10	105174762	105174762	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:105174762G>T	ENST00000369797.3	+	12	1466	c.1371_splice	c.e12-1	p.G458_splice		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	458	S1 motif 5.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GATTCTCTAGGGCACAGTGCT	0.517000													7	43					8.12818e-05	9.73492e-05	1	1	0
PLEK2	26499	broad.mit.edu	37	14	67862182	67862182	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:67862182C>A	ENST00000216446.4	-	3	466	c.326G>T	c.(325-327)gGg>gTg	p.G109V		NM_016445.1	NP_057529.1	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	109					actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	15				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		CTGGACCTTCCCCGGCTGCCC	0.617000													15	70					7.93312e-07	1.04758e-06	1	1	0
PCSK4	54760	broad.mit.edu	37	19	1487181	1487181	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:1487181C>A	ENST00000300954.5	-	7	875	c.814G>T	c.(814-816)Ggc>Tgc	p.G272C		NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	272	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAGGATGCCGGGGCCGTCC	0.721000													4	42					1	1	1	1	0
PCSK4	54760	broad.mit.edu	37	19	1487180	1487180	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:1487180C>A	ENST00000300954.5	-	7	876	c.815G>T	c.(814-816)gGc>gTc	p.G272V		NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	272	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGAGGATGCCGGGGCCGTC	0.726000													4	42					1	1	1	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29899989	29899989	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:29899989G>A	ENST00000308713.5	-	6	1438	c.911C>T	c.(910-912)aCg>aTg	p.T304M	SEZ6L2_ENST00000537485.1_Missense_Mutation_p.T260M|SEZ6L2_ENST00000562159.1_5'UTR|SEZ6L2_ENST00000350527.3_Missense_Mutation_p.T234M|SEZ6L2_ENST00000346932.5_Missense_Mutation_p.T190M	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	304	Sushi 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTGCAGGTCCGTCACACTCAC	0.647000													14	33					0	0	1	0	0
OMA1	115209	broad.mit.edu	37	1	59004730	59004730	+	Silent	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:59004730T>A	ENST00000371226.3	-	2	350	c.237A>T	c.(235-237)acA>acT	p.T79T	OMA1_ENST00000358603.2_Silent_p.T79T|DAB1_ENST00000485760.1_Intron|OMA1_ENST00000467063.1_Intron	NM_145243.3	NP_660286.1	Q96E52	OMA1_HUMAN	OMA1 zinc metallopeptidase	79					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			NS(1)|breast(1)|large_intestine(6)|liver(2)|lung(6)|prostate(1)|skin(1)	18	all_cancers(7;6.54e-05)					AGAGGCCTCCTGTTCTTTTGT	0.368000													24	89					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819551	159819551	+	RNA	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:159819551T>C	ENST00000497452.1	-	0	517																											AAAGCAATAATTTAGAGAGAG	0.443000													11	210					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113326717	113326717	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr8:113326717G>A	ENST00000297405.5	-	48	7734	c.7490C>T	c.(7489-7491)aCc>aTc	p.T2497I	CSMD3_ENST00000352409.3_Missense_Mutation_p.T2427I|CSMD3_ENST00000455883.2_Missense_Mutation_p.T2393I|CSMD3_ENST00000343508.3_Missense_Mutation_p.T2457I	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2497	CUB 14.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TACAAACATGGTGATATTATA	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	57					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907357	77907357	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:77907357G>T	ENST00000355300.6	-	2	1066	c.892C>A	c.(892-894)Ccc>Acc	p.P298T	LINGO1_ENST00000561030.1_Missense_Mutation_p.P292T	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	298				P -> R (in Ref. 5; AAH68558).	negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GTGCTGATGGGGTTGTAGGAG	0.617000													8	31					5.18039e-06	6.66975e-06	1	1	0
POLE	5426	broad.mit.edu	37	12	133210946	133210946	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:133210946C>T	ENST00000320574.5	-	43	5873	c.5830G>A	c.(5830-5832)Ggg>Agg	p.G1944R	POLE_ENST00000535270.1_Missense_Mutation_p.G1917R	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1944					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		tcTGCTCCCCCTGCTTTCTGG	0.567000								DNA polymerases (catalytic subunits)					14	66					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228520564	228520564	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:228520564C>A	ENST00000570156.2	+	68	18601	c.18527C>A	c.(18526-18528)aCa>aAa	p.T6176K	OBSCN_ENST00000284548.11_Missense_Mutation_p.T5219K|OBSCN_ENST00000366709.4_Missense_Mutation_p.T2338K|OBSCN_ENST00000366707.4_Missense_Mutation_p.T2853K|OBSCN_ENST00000422127.1_Missense_Mutation_p.T5219K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5219	Ig-like 53.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCCCAGTGACAAGCACAGAC	0.607000													4	56					0.184627	0.186437	1	1	0
RAB9BP1	9366	broad.mit.edu	37	5	104435322	104435322	+	RNA	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:104435322G>C	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							TAAAGATTTGGAAGTGGATGG	0.393000													11	70					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50723069	50723069	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:50723069G>T	ENST00000404971.1	-	16	4503	c.3164C>A	c.(3163-3165)gCc>gAc	p.A1055D	NRXN1_ENST00000401669.2_Missense_Mutation_p.A1015D|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401710.1_Missense_Mutation_p.A24D|NRXN1_ENST00000406859.3_Missense_Mutation_p.A1015D|NRXN1_ENST00000405472.3_Missense_Mutation_p.A1007D|NRXN1_ENST00000406316.2_Missense_Mutation_p.A1015D|NRXN1_ENST00000402717.3_Missense_Mutation_p.A1007D	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1015	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCTGGCTCCGGCGGTGATTTG	0.473000													13	28					0.000151284	0.000178594	1	1	0
DLGAP4	22839	broad.mit.edu	37	20	35060337	35060337	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:35060337C>T	ENST00000373913.3	+	3	697	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C	DLGAP4_ENST00000373907.2_Missense_Mutation_p.R73C|DLGAP4_ENST00000401952.2_Missense_Mutation_p.R73C|DLGAP4_ENST00000339266.5_Missense_Mutation_p.R73C			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	73					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CACCTTTCCCCGCATCCACTA	0.662000													14	57					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168137953	168137953	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:168137953G>A	ENST00000519560.1	-	25	3085	c.2666C>T	c.(2665-2667)cCc>cTc	p.P889L	CTC-558O2.1_ENST00000522615.1_RNA|SLIT3_ENST00000332966.8_Missense_Mutation_p.P889L|SLIT3_ENST00000404867.3_Missense_Mutation_p.P889L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	889	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCAGCCATGGGCTCAGGGCT	0.652000													2	1					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135587338	135587338	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:135587338G>T	ENST00000513104.1	-	6	1860	c.1579_splice	c.e6+1	p.Y526_splice	TRPC7_ENST00000355180.3_Splice_Site_p.Y465_splice|TRPC7_ENST00000426057.2_Splice_Site_p.Y410_splice	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	526					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding	p.Y526Y(2)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCGACTCACCGTAGGTGAAGT	0.577000													4	19					0.184627	0.186437	1	1	0
KIAA1211	57482	broad.mit.edu	37	4	57181843	57181843	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:57181843G>T	ENST00000504228.1	+	6	2280	c.2175G>T	c.(2173-2175)tgG>tgT	p.W725C	KIAA1211_ENST00000264229.6_Missense_Mutation_p.W725C|KIAA1211_ENST00000541073.1_Missense_Mutation_p.W718C			Q6ZU35	K1211_HUMAN	KIAA1211	725										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TGCCTGCCTGGCAGAAATTTT	0.572000													10	84					1.33987e-11	2.29057e-11	1	1	0
FGFR4	2264	broad.mit.edu	37	5	176524383	176524383	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:176524383G>T	ENST00000292408.4	+	17	2489	c.2244G>T	c.(2242-2244)ctG>ctT	p.L748L	FGFR4_ENST00000393648.2_Silent_p.L680L|FGFR4_ENST00000502906.1_Silent_p.L748L|FGFR4_ENST00000393637.1_Silent_p.L708L|FGFR4_ENST00000292410.3_Silent_p.L708L	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	748	Protein kinase.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGGTCCTGCTGGCCGTCTCTG	0.682000										TSP Lung(9;0.080)			7	18					0.0293803	0.0303376	1	1	0
POTEG	404785	broad.mit.edu	37	14	19553629	19553629	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:19553629G>T	ENST00000409832.3	+	1	265	c.213G>T	c.(211-213)tgG>tgT	p.W71C		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	71										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GCTTCCCCTGGTGCAGGGGGA	0.587000													23	344					1.75199e-13	3.12475e-13	1	1	0
TACC2	10579	broad.mit.edu	37	10	123842458	123842458	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:123842458G>C	ENST00000369005.1	+	4	783	c.443G>C	c.(442-444)gGa>gCa	p.G148A	TACC2_ENST00000515273.1_Missense_Mutation_p.G148A|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.G148A|TACC2_ENST00000453444.2_Missense_Mutation_p.G148A|TACC2_ENST00000515603.1_Missense_Mutation_p.G148A|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	148						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AATGCCCCAGGAGACATCGCG	0.602000													7	64					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526316	176526316	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:176526316G>T	ENST00000367662.3	+	2	2022	c.858G>T	c.(856-858)gcG>gcT	p.A286A	PAPPA2_ENST00000367661.3_Silent_p.A286A	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	286					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCCGGGAGGCGTTCACAGTGG	0.572000													14	27					4.3838e-07	5.96081e-07	1	1	0
ZNF285	26974	broad.mit.edu	37	19	44891051	44891051	+	Silent	SNP	C	C	A	rs147324190		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:44891051C>A	ENST00000330997.4	-	4	1420	c.1356G>T	c.(1354-1356)ggG>ggT	p.G452G	ZNF285_ENST00000591679.1_Silent_p.G459G|ZNF285_ENST00000544719.2_Silent_p.G452G|CTC-512J12.6_ENST00000588212.1_Intron	NM_152354.3	NP_689567.3			zinc finger protein 285									p.G452G(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						ATGGTTTCTCCCCTGTGTGGA	0.448000													18	73					2.48551e-13	4.41391e-13	1	1	0
ZNF486	90649	broad.mit.edu	37	19	20307866	20307866	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:20307866G>T	ENST00000335117.8	+	4	404	c.347G>T	c.(346-348)gGa>gTa	p.G116V	CTC-260E6.6_ENST00000585498.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						GAAAAATGTGGACATGGCAAT	0.363000													13	92					0.00136819	0.0015235	1	1	0
ITGB3	3690	broad.mit.edu	37	17	45369932	45369932	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:45369932C>A	ENST00000559488.1	+	10	1704	c.1688C>A	c.(1687-1689)tCa>tAa	p.S563*	ITGB3_ENST00000435993.2_Nonsense_Mutation_p.S516*|ITGB3_ENST00000560629.1_Silent_p.L551L	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	563	Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	GAGATGTGCTCAGGTGAGGAG	0.562000													22	111					7.41877e-09	1.11961e-08	1	1	0
RECQL5	9400	broad.mit.edu	37	17	73658964	73658964	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:73658964C>T	ENST00000420326.2	-	4	525	c.366G>A	c.(364-366)caG>caA	p.Q122Q	RECQL5_ENST00000423245.2_Silent_p.Q95Q|RECQL5_ENST00000317905.5_Silent_p.Q122Q|RECQL5_ENST00000584999.1_Silent_p.Q122Q|RECQL5_ENST00000340830.5_Silent_p.Q122Q	NM_001003715.3|NM_001003716.3	NP_001003715.1|NP_001003716.1	O94762	RECQ5_HUMAN	RecQ protein-like 5	122	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GAATCTTGGTCTGGGGCTTTT	0.547000								Other identified genes with known or suspected DNA repair function					46	204					0	0	1	0	0
HAND2	9464	broad.mit.edu	37	4	174449996	174449996	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:174449996C>A	ENST00000359562.4	-	1	1384	c.445G>T	c.(445-447)Gcc>Tcc	p.A149S	HAND2_ENST00000505300.1_5'UTR|HAND2-AS1_ENST00000512099.1_RNA|HAND2-AS1_ENST00000515310.1_RNA	NM_021973.2	NP_068808.1	P61296	HAND2_HUMAN	heart and neural crest derivatives expressed 2	149	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	13		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		ATGAGGTAGGCGATGTAGCTG	0.592000													22	71					8.10497e-08	1.15946e-07	1	1	0
SLC39A1	27173	broad.mit.edu	37	1	153932866	153932866	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:153932866C>A	ENST00000368623.3	-	3	1442	c.683G>T	c.(682-684)cGg>cTg	p.R228L	SLC39A1_ENST00000356205.4_Missense_Mutation_p.R228L|SLC39A1_ENST00000310483.6_Missense_Mutation_p.R228L|SLC39A1_ENST00000537590.1_Missense_Mutation_p.R126L|SLC39A1_ENST00000368621.1_Missense_Mutation_p.R228L			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	228						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		CTGCAACAGCCGCAGGGACAG	0.652000													11	59					3.86212e-05	4.72164e-05	1	1	0
EFCAB4B	84766	broad.mit.edu	37	12	3782739	3782739	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:3782739G>A	ENST00000440314.2	-	7	1017	c.544C>T	c.(544-546)Ctc>Ttc	p.L182F	EFCAB4B_ENST00000444507.1_Missense_Mutation_p.L182F|EFCAB4B_ENST00000252322.1_Missense_Mutation_p.L182F	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	182					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TGCAACCAGAGCTGCTTGACA	0.493000													23	66					0	0	1	0	0
IFNA4	3441	broad.mit.edu	37	9	21187346	21187346	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:21187346G>T	ENST00000421715.1	-	1	252	c.185C>A	c.(184-186)cCc>cAc	p.P62H		NM_021068.2	NP_066546.1	P05014	IFNA4_HUMAN	interferon, alpha 4	62					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTCCTCCTCGGGGAATCCGAA	0.517000													34	92					9.17885e-22	1.83577e-21	1	1	0
ACIN1	22985	broad.mit.edu	37	14	23531434	23531434	+	Silent	SNP	G	G	A	rs147049684	byFrequency	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:23531434G>A	ENST00000262710.1	-	16	3543	c.3216C>T	c.(3214-3216)gtC>gtT	p.V1072V	ACIN1_ENST00000555053.1_Silent_p.V1059V|ACIN1_ENST00000357481.2_Silent_p.V314V|ACIN1_ENST00000457657.1_Silent_p.V1032V|ACIN1_ENST00000338631.6_Silent_p.V345V|ACIN1_ENST00000397341.3_Silent_p.V314V|ACIN1_ENST00000605057.1_Silent_p.V1014V|ACIN1_ENST00000557515.1_Silent_p.V313V	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1072					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGGGCCATTTGACCCCGTGCA	0.547000													9	132					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558606	210558606	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:210558606A>G	ENST00000360351.4	+	7	2218	c.1712A>G	c.(1711-1713)aAg>aGg	p.K571R	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.K567R	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	571					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GGAATGTCCAAGTACTTTGAA	0.393000													7	79					0	0	1	0	0
TM6SF2	53345	broad.mit.edu	37	19	19378872	19378872	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:19378872G>T	ENST00000389363.4	-	7	706	c.634C>A	c.(634-636)Ctc>Atc	p.L212I	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	212						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			CGCTGCAGGAGTCCCTTTCTT	0.527000													11	36					0.000673444	0.000753965	1	1	0
TSPAN18	90139	broad.mit.edu	37	11	44931364	44931364	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:44931364C>A	ENST00000340160.3	+	4	411	c.172C>A	c.(172-174)Ctc>Atc	p.L58I	TSPAN18_ENST00000520358.2_Missense_Mutation_p.L58I	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	58						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						CGCCTACATCCTCCTGGCCAT	0.652000													11	59					0.0135373	0.0144118	1	1	0
ZNF335	63925	broad.mit.edu	37	20	44590776	44590776	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:44590776C>A	ENST00000322927.2	-	10	1679	c.1579G>T	c.(1579-1581)Gag>Tag	p.E527*	ZNF335_ENST00000426788.1_Nonsense_Mutation_p.E372*	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TAGCTGCACTCGTCACACTTG	0.627000													25	95					2.44723e-14	4.42219e-14	1	1	0
CSMD2	114784	broad.mit.edu	37	1	34254306	34254306	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:34254306C>T	ENST00000373381.4	-	12	1734	c.1558G>A	c.(1558-1560)Ggt>Agt	p.G520S	CSMD2_ENST00000338325.1_Missense_Mutation_p.G128S	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	480	Sushi 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCGATGTACCTGTCAGGCTG	0.498000													12	56					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21229499	21229499	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:21229499T>A	ENST00000540229.1	+	15	2109	c.2044T>A	c.(2044-2046)Ttg>Atg	p.L682M	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.L621M|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.L574M|RP11-125O5.2_ENST00000590779.1_Silent_p.I74I|LST3_ENST00000381541.3_Missense_Mutation_p.L621M|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.L682M																							TTCCACATATTTGGGGTAAGT	0.318000													27	109					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8868746	8868746	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:8868746G>T	ENST00000396600.2	+	13	1892		c.e13-1		ABAT_ENST00000425191.2_Splice_Site|ABAT_ENST00000268251.8_Splice_Site|ABAT_ENST00000567812.1_Splice_Site|ABAT_ENST00000569156.1_Splice_Site	NM_000663.4	NP_000654.2	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase						behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	TCTCCGGCCAGCATGGCTGCG	0.612000													6	78					5.9392e-07	7.99657e-07	1	1	0
FAM212A	389119	broad.mit.edu	37	3	49841970	49841970	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:49841970C>A	ENST00000333323.4	+	2	547	c.414C>A	c.(412-414)agC>agA	p.S138R		NM_203370.1	NP_976248.1	Q96EL1	CC054_HUMAN	family with sequence similarity 212, member A	136																	CCATGCCCAGCAGGGCCCCTG	0.647000													9	43					0.000274275	0.000313893	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31324851	31324851	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:31324851G>C	ENST00000269197.5	+	12	5039	c.5039G>C	c.(5038-5040)aGa>aCa	p.R1680T		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1680					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AAGGGCTTTAGAATGGACACT	0.488000													8	99					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646871	57646871	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:57646871G>T	ENST00000269834.1	-	5	1219	c.834C>A	c.(832-834)tcC>tcA	p.S278S		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACACTGATAGGATTTCTTGG	0.368000													36	131					1.22384e-17	2.36723e-17	1	1	0
RALGDS	5900	broad.mit.edu	37	9	135984156	135984156	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:135984156C>T	ENST00000393160.3	-	5	870	c.517G>A	c.(517-519)Gtg>Atg	p.V173M	RALGDS_ENST00000372047.3_Missense_Mutation_p.V216M|RALGDS_ENST00000393157.3_Missense_Mutation_p.V227M|RALGDS_ENST00000542690.1_Missense_Mutation_p.V299M|RALGDS_ENST00000372062.3_Missense_Mutation_p.V199M|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000372050.3_Missense_Mutation_p.V228M	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	228	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TTGAGCTGCACGTAGGCCACC	0.622000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								12	28					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905395	144905395	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:144905395G>T	ENST00000370490.1	+	1	5707	c.1452G>T	c.(1450-1452)cgG>cgT	p.R484R	SLITRK2_ENST00000447897.2_Silent_p.R484R|SLITRK2_ENST00000434188.2_Silent_p.R484R|SLITRK2_ENST00000428560.2_Silent_p.R484R|SLITRK2_ENST00000413937.2_Silent_p.R484R			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	484						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTTCTTCGGTCCTTACCTG	0.423000													64	87					4.60343e-24	9.29712e-24	1	1	0
ZNF77	58492	broad.mit.edu	37	19	2933766	2933766	+	Silent	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:2933766C>T	ENST00000314531.4	-	4	1451	c.1359G>A	c.(1357-1359)gaG>gaA	p.E453E		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCGCACATGCTCTCGAAGGG	0.512000													13	76					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43234158	43234158	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:43234158T>G	ENST00000327495.5	-	4	944	c.760A>C	c.(760-762)Aat>Cat	p.N254H	PSG3_ENST00000595140.1_Missense_Mutation_p.N254H	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	254	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				ACATCCTTATTCTCCCTGGGG	0.488000													54	238					0	0	1	0	0
ZDHHC4	55146	broad.mit.edu	37	7	6620241	6620241	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:6620241G>A	ENST00000396706.2	+	3	492	c.49G>A	c.(49-51)Ggt>Agt	p.G17S	ZDHHC4_ENST00000396707.2_Missense_Mutation_p.G17S|ZDHHC4_ENST00000496017.1_3'UTR|AC079742.4_ENST00000434951.1_RNA|ZDHHC4_ENST00000396713.2_Missense_Mutation_p.G17S|ZDHHC4_ENST00000396709.1_Missense_Mutation_p.G17S|ZDHHC4_ENST00000335965.6_Missense_Mutation_p.G17S|ZDHHC4_ENST00000405731.3_Missense_Mutation_p.G17S			Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	17						integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		GGTGCTGATGGGTCTTGTTCT	0.493000													15	234					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47407540	47407540	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr21:47407540C>A	ENST00000361866.3	+	8	890	c.776C>A	c.(775-777)cCg>cAg	p.P259Q		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	259	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGAGGACCTCCGGGGCTCCGG	0.697000													12	49					0.00010058	0.000119766	1	1	0
CDH8	1006	broad.mit.edu	37	16	61891107	61891107	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:61891107C>A	ENST00000577390.1	-	4	1537	c.583G>T	c.(583-585)Gat>Tat	p.D195Y	CDH8_ENST00000584337.1_Missense_Mutation_p.D195Y|CDH8_ENST00000577730.1_Missense_Mutation_p.D195Y|CDH8_ENST00000299345.6_Missense_Mutation_p.D195Y	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	195	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ACTGGGTCATCAGCGTCGGTC	0.378000													11	64					0.000673444	0.000753965	1	1	0
GLT1D1	144423	broad.mit.edu	37	12	129431955	129431955	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:129431955G>T	ENST00000442111.2	+	10	820	c.732G>T	c.(730-732)gcG>gcT	p.A244A	GLT1D1_ENST00000281703.6_Silent_p.A164A|GLT1D1_ENST00000542193.1_Silent_p.A161A|GLT1D1_ENST00000537468.1_Silent_p.A249A			Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	244					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		ATTGCTTCGCGGTGGTGAATA	0.483000													7	50					0.0381472	0.0391937	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													8	161					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40037129	40037129	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:40037129C>G	ENST00000336649.4	+	8	998	c.998C>G	c.(997-999)cCc>cGc	p.P333R	CACNA1I_ENST00000407673.1_Missense_Mutation_p.P333R|CACNA1I_ENST00000402142.3_Missense_Mutation_p.P333R|CACNA1I_ENST00000401624.1_Missense_Mutation_p.P333R|CACNA1I_ENST00000400164.3_Missense_Mutation_p.P333R|CACNA1I_ENST00000404898.1_Missense_Mutation_p.P333R			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	333					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	AGCGCCAACCCCCACAAGGGT	0.592000													6	76					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65756107	65756107	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:65756107C>T	ENST00000341861.5	-	15	3591	c.2011G>A	c.(2011-2013)Ggt>Agt	p.G671S	DPP8_ENST00000321118.7_Missense_Mutation_p.G671S|DPP8_ENST00000321147.6_Missense_Mutation_p.G671S|DPP8_ENST00000300141.6_Missense_Mutation_p.G655S|DPP8_ENST00000358939.4_Missense_Mutation_p.G655S|DPP8_ENST00000559233.1_Missense_Mutation_p.G671S|DPP8_ENST00000339244.5_Missense_Mutation_p.G498S	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	671					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ACCTGAGGACCACCATATATG	0.333000													11	53					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21523882	21523882	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr18:21523882A>G	ENST00000313654.9	+	69	9398	c.9157A>G	c.(9157-9159)Aaa>Gaa	p.K3053E	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.K1388E|LAMA3_ENST00000269217.6_Missense_Mutation_p.K1444E|LAMA3_ENST00000399516.3_Missense_Mutation_p.K2997E	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	3053	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACAGATGGGAAAAAATTGAG	0.468000													6	51					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			18	118					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30725633	30725633	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:30725633G>T	ENST00000361762.2	+	1	3597	c.2589G>T	c.(2587-2589)caG>caT	p.Q863H	PCDH7_ENST00000543491.1_Missense_Mutation_p.Q863H	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	863					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CACTCACCCAGGATATAGCTG	0.448000													7	66					5.18039e-06	6.66975e-06	1	1	0
ABCG5	64240	broad.mit.edu	37	2	44047066	44047066	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:44047066G>T	ENST00000543989.1	-	7	2157	c.452C>A	c.(451-453)tCt>tAt	p.S151Y	ABCG5_ENST00000405322.1_Missense_Mutation_p.S375Y|ABCG5_ENST00000260645.1_Missense_Mutation_p.S546Y			Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	546	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GAGGAATCCAGATCCAACAAG	0.378000													17	80					1.67942e-08	2.4979e-08	1	1	0
ITGBL1	9358	broad.mit.edu	37	13	102220103	102220103	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:102220103G>T	ENST00000376180.3	+	3	589	c.370G>T	c.(370-372)Gat>Tat	p.D124Y	ITGBL1_ENST00000545560.2_5'UTR|ITGBL1_ENST00000376162.3_Missense_Mutation_p.D31Y	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	124	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATGGTATGGGGATGCTTGCCA	0.433000													15	108					3.27435e-08	4.80083e-08	1	1	0
EBI3	10148	broad.mit.edu	37	19	4231320	4231320	+	Splice_Site	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:4231320G>T	ENST00000221847.5	+	2	253	c.200_splice	c.e2+1	p.R67_splice		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	67	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCACGTACAGGTCGGAGAGC	0.642000													5	20					0.0215528	0.0223671	1	1	0
PROX1	5629	broad.mit.edu	37	1	214178587	214178587	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:214178587T>A	ENST00000366958.4	+	3	2413	c.1805T>A	c.(1804-1806)aTg>aAg	p.M602K	PROX1_ENST00000435016.1_Missense_Mutation_p.M602K|PROX1_ENST00000498508.2_Missense_Mutation_p.M602K|PROX1_ENST00000261454.4_Missense_Mutation_p.M602K	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	602					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AGCTCCAATATGCTGAAGACC	0.383000													17	70					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99685368	99685368	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:99685368T>C	ENST00000393483.3	-	15	2045	c.1201A>G	c.(1201-1203)Aat>Gat	p.N401D	TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000410001.1_Missense_Mutation_p.N401D|TSGA10_ENST00000355053.4_Missense_Mutation_p.N401D|TSGA10_ENST00000539964.1_Missense_Mutation_p.N401D	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	401					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TTTAATATATTCTTCAGCTTG	0.303000													6	47					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801468	196801468	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:196801468G>T	ENST00000312428.6	-	20	3227	c.3127C>A	c.(3127-3129)Ctg>Atg	p.L1043M		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1043	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GATTTTTTCAGCCTTTCCAGC	0.299000													7	40					0.000157383	0.000185263	1	1	0
ZNF43	7594	broad.mit.edu	37	19	22000689	22000689	+	Splice_Site	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:22000689C>A	ENST00000594012.1	-	6	726		c.e6+1		ZNF43_ENST00000595461.1_Splice_Site|ZNF43_ENST00000598288.1_Splice_Site|ZNF43_ENST00000354959.4_Splice_Site|ZNF43_ENST00000598381.1_Splice_Site	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTCTCACCTACCTGGGGGTTT	0.468000													20	115					1.2644e-06	1.66433e-06	1	1	0
FAM129C	199786	broad.mit.edu	37	19	17660439	17660439	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:17660439G>T	ENST00000595684.1	+	15	2084	c.1946G>T	c.(1945-1947)tGg>tTg	p.W649L	FAM129C_ENST00000599124.1_Intron|FAM129C_ENST00000332386.5_Intron|FAM129C_ENST00000335393.4_Intron|FAM129C_ENST00000599164.1_Intron|FAM129C_ENST00000449408.2_Intron|FAM129C_ENST00000352727.3_Intron|FAM129C_ENST00000600871.1_Intron|FAM129C_ENST00000601861.1_Intron			Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	0										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						GTGGGTTCATGGACGGAACAG	0.562000													6	24					3.59834e-05	4.42542e-05	1	1	0
CCDC80	151887	broad.mit.edu	37	3	112356938	112356938	+	Silent	SNP	C	C	G	rs146058748		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:112356938C>G	ENST00000206423.3	-	2	2768	c.1815G>C	c.(1813-1815)acG>acC	p.T605T	CCDC80_ENST00000439685.2_Silent_p.T605T	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	605	Lys-rich.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						TGGGACTCTGCGTGAAGTGTT	0.473000													16	197					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47549737	47549737	+	Splice_Site	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:47549737A>T	ENST00000359314.5	+	11	1501		c.e11-1			NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein						cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TTTTTCCCATAGCTCCAAAGC	0.303000													12	78					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5862847	5862847	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr4:5862847G>T	ENST00000324989.7	-	3	649	c.561C>A	c.(559-561)aaC>aaA	p.N187K	CRMP1_ENST00000512574.1_Missense_Mutation_p.N71K|CRMP1_ENST00000397890.2_Missense_Mutation_p.N73K|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	73					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		GCAGGTACGTGTTGACATCAA	0.552000													11	56					0.0135373	0.0144118	1	1	0
ZNF292	23036	broad.mit.edu	37	6	87967283	87967283	+	Silent	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:87967283G>T	ENST00000369577.3	+	8	3979	c.3936G>T	c.(3934-3936)ggG>ggT	p.G1312G	ZNF292_ENST00000339907.4_Silent_p.G1307G	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TTCTAAAGGGGGGTAATGGTG	0.368000													8	10					0.00448238	0.00491155	1	1	0
ENTHD1	150350	broad.mit.edu	37	22	40139818	40139818	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:40139818C>A	ENST00000325157.6	-	7	1940	c.1690G>T	c.(1690-1692)Gaa>Taa	p.E564*		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	564										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CTCAGATCTTCATGTAATCTA	0.418000													15	61					6.31663e-08	9.1314e-08	1	1	0
PRKD1	5587	broad.mit.edu	37	14	30105570	30105570	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:30105570C>A	ENST00000331968.5	-	7	1345	c.1116G>T	c.(1114-1116)atG>atT	p.M372I	PRKD1_ENST00000415220.2_Missense_Mutation_p.M380I	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	372					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGCACTCTGCCATTGCCATCT	0.527000													15	129					6.31663e-08	9.1314e-08	1	1	0
TULP4	56995	broad.mit.edu	37	6	158923144	158923144	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:158923144G>T	ENST00000367097.3	+	13	3806	c.2449G>T	c.(2449-2451)Gca>Tca	p.A817S	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	817					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TGAGGGGGACGCAGTGGTCTT	0.657000													7	28					2.0095e-06	2.61998e-06	1	1	0
HELZ2	85441	broad.mit.edu	37	20	62198344	62198344	+	Silent	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:62198344T>A	ENST00000467148.1	-	6	2436	c.2367A>T	c.(2365-2367)ccA>ccT	p.P789P	HELZ2_ENST00000427522.2_Silent_p.P220P	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TGTCCCGGTCTGGGCTGCCCG	0.657000													18	80					0	0	1	0	0
CASP5	838	broad.mit.edu	37	11	104869617	104869617	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:104869617G>T	ENST00000393141.2	-	7	1161	c.1130C>A	c.(1129-1131)aCa>aAa	p.T377K	CASP5_ENST00000418434.1_Missense_Mutation_p.T222K|CASP5_ENST00000393139.2_3'UTR|CASP5_ENST00000260315.3_Missense_Mutation_p.T364K|CASP5_ENST00000444749.2_Missense_Mutation_p.T306K|CASP5_ENST00000526056.1_Missense_Mutation_p.T377K|CASP5_ENST00000531367.1_Missense_Mutation_p.T222K	NM_001136112.1|NM_004347.3	NP_001129584.1|NP_004338.3	P51878	CASP5_HUMAN	caspase 5, apoptosis-related cysteine peptidase	364					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|ovary(3)|skin(1)|urinary_tract(1)	35		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		CATACGTGGTGTTGAAGAACA	0.438000													29	125					5.77227e-19	1.13246e-18	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78340146	78340146	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr5:78340146G>A	ENST00000255189.3	-	6	1003	c.975C>T	c.(973-975)gtC>gtT	p.V325V	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Silent_p.V124V	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	325					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CTCCATTGGTGACCCAGGAGT	0.463000													25	106					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108292216	108292216	+	Splice_Site	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:108292216C>A	ENST00000370056.4	-	14	1534	c.1259_splice	c.e14-1	p.R420_splice	VAV3_ENST00000371846.4_Splice_Site_p.R355_splice|VAV3_ENST00000527011.1_Splice_Site_p.R420_splice|VAV3_ENST00000343258.4_5'UTR	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	420	PH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AGAAGATATGCCTGGGAAAAA	0.303000													5	36					0.014758	0.0155109	1	1	0
VWF	7450	broad.mit.edu	37	12	6161928	6161928	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:6161928T>A	ENST00000261405.5	-	16	2221	c.1967A>T	c.(1966-1968)cAg>cTg	p.Q656L		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	656	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CAGGTACACCTGGCCTTTCGG	0.587000													12	44					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87628878	87628878	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:87628878C>A	ENST00000327946.7	-	6	925	c.840G>T	c.(838-840)gtG>gtT	p.V280V		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	280						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TTTGCCGGACCACGGTCATCC	0.537000										Multiple Myeloma(13;0.14)			20	72					4.35082e-09	6.71362e-09	1	1	0
PRRT3	285368	broad.mit.edu	37	3	9991566	9991566	+	Silent	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:9991566G>A	ENST00000412055.1	-	2	363	c.234C>T	c.(232-234)gcC>gcT	p.A78A	PRRT3-AS1_ENST00000431558.1_RNA|PRRT3_ENST00000411976.2_Silent_p.A78A	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3	78						integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						CTTCAGCAGGGGCGTGGCGGA	0.627000													9	67					0	0	1	0	0
MEN1	4221	broad.mit.edu	37	11	64575565	64575565	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:64575565T>G	ENST00000337652.1	-	3	970	c.467A>C	c.(466-468)aAa>aCa	p.K156T	MEN1_ENST00000377326.3_Missense_Mutation_p.K151T|MEN1_ENST00000315422.4_Missense_Mutation_p.K151T|MEN1_ENST00000377316.2_Missense_Mutation_p.K151T|MEN1_ENST00000377313.1_Missense_Mutation_p.K156T|MEN1_ENST00000394376.1_Missense_Mutation_p.K156T|MEN1_ENST00000377321.1_Missense_Mutation_p.K151T|MEN1_ENST00000394374.2_Missense_Mutation_p.K156T|MEN1_ENST00000312049.6_Missense_Mutation_p.K151T|MEN1_ENST00000443283.1_Missense_Mutation_p.K156T	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	156					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						GCTGTCCAATTTGGTGCCTGT	0.612000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				3	14					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148880	125148880	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:125148880C>A	ENST00000362012.2	+	9	1170	c.1165C>A	c.(1165-1167)Ctc>Atc	p.L389I	PTGS1_ENST00000223423.4_Missense_Mutation_p.L389I|AL162424.1_ENST00000600713.1_Intron|PTGS1_ENST00000373698.5_Missense_Mutation_p.L280I|PTGS1_ENST00000540753.1_Missense_Mutation_p.L364I	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	389					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CTGGCACCCCCTCATGCCTGA	0.552000													29	120					1.39806e-14	2.56e-14	1	1	0
SLC25A24	29957	broad.mit.edu	37	1	108681794	108681794	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:108681794C>G	ENST00000565488.1	-	9	1354	c.1135G>C	c.(1135-1137)Gat>Cat	p.D379H	SLC25A24_ENST00000370041.4_Missense_Mutation_p.D360H	NM_013386.4	NP_037518.3	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	379					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TTTACAGAATCTTTTGCAAAA	0.443000													7	86					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120589093	120589093	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:120589093C>G	ENST00000300648.6	-	34	4177	c.4165G>C	c.(4165-4167)Gac>Cac	p.D1389H		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1389					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGTACTTGTCTGACTCCAGC	0.622000													14	47					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31138622	31138622	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:31138622C>A	ENST00000538351.1	-	7	1319	c.565G>T	c.(565-567)Ggg>Tgg	p.G189W	ZNF438_ENST00000436087.2_Missense_Mutation_p.G238W|ZNF438_ENST00000331737.6_Missense_Mutation_p.G228W|ZNF438_ENST00000452305.1_Missense_Mutation_p.G228W|ZNF438_ENST00000361310.3_Missense_Mutation_p.G238W|ZNF438_ENST00000444692.2_Missense_Mutation_p.G228W|ZNF438_ENST00000442986.1_Missense_Mutation_p.G238W|ZNF438_ENST00000413025.1_Missense_Mutation_p.G238W|ZNF438_ENST00000375311.1_Intron	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGTGCTTTCCCTGAAAGAGCT	0.473000													15	178					3.41278e-10	5.55757e-10	1	1	0
OR10G9	219870	broad.mit.edu	37	11	123894445	123894445	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr11:123894445C>A	ENST00000375024.1	+	1	726	c.726C>A	c.(724-726)tcC>tcA	p.S242S		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTGTGCCTCCCACTGCATCG	0.522000													18	111					5.35267e-07	7.25427e-07	1	1	0
ZFP30	22835	broad.mit.edu	37	19	38126847	38126847	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:38126847C>A	ENST00000351218.2	-	6	1152	c.595G>T	c.(595-597)Gcc>Tcc	p.A199S	ZFP30_ENST00000514101.2_Missense_Mutation_p.A199S|ZFP30_ENST00000589018.1_Intron|ZFP30_ENST00000392144.1_Missense_Mutation_p.A199S	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGAGGTGGGCACACTGTCTA	0.393000													22	148					0.000375601	0.000428664	1	1	0
BRAF	673	broad.mit.edu	37	7	140453149	140453149	+	Missense_Mutation	SNP	C	C	T	rs121913361		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:140453149C>T	ENST00000288602.6	-	15	1846	c.1786G>A	c.(1786-1788)Ggt>Agt	p.G596S		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	596	Protein kinase.		G -> R (in a colorectal adenocarcinoma sample; somatic mutation).|G -> V (in CFC syndrome).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G596R(6)|p.G596fs*2(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGCTAGACCAAAATCACCT	0.388000	G596R(NCIH508_LARGE_INTESTINE)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				20	65					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78598856	78598856	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:78598856T>A	ENST00000397909.2	+	39	7149	c.6976T>A	c.(6976-6978)Tcc>Acc	p.S2326T	NAV3_ENST00000536525.2_Missense_Mutation_p.S2304T|NAV3_ENST00000266692.7_Missense_Mutation_p.S2127T|NAV3_ENST00000541270.1_Missense_Mutation_p.S156T|NAV3_ENST00000228327.6_Missense_Mutation_p.S2304T			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2326						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AAGCTGCACATCCACTAAGGA	0.483000										HNSCC(70;0.22)			8	49					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69145871	69145871	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:69145871G>T	ENST00000398004.2	+	3	845	c.573G>T	c.(571-573)caG>caT	p.Q191H		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	191						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TGTACTACCAGGCTCCGATGT	0.458000													35	148					1.45844e-13	2.6125e-13	1	1	0
MBL2	4153	broad.mit.edu	37	10	54531269	54531269	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr10:54531269T>A	ENST00000373968.3	-	1	191	c.127A>T	c.(127-129)Atc>Ttc	p.I43F		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	43	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						AAGCCGTTGATGCCTGGAGAG	0.537000													7	60					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100672325	100672325	+	Silent	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:100672325C>A	ENST00000268070.4	-	12	1713	c.1608G>T	c.(1606-1608)acG>acT	p.T536T		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	536	Disintegrin.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CCGGGATGGGCGTCTTGCTCA	0.687000											OREG0023513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	24					8.12818e-05	9.73492e-05	1	1	0
SLC6A13	6540	broad.mit.edu	37	12	333166	333166	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr12:333166G>A	ENST00000343164.4	-	11	1355	c.1303C>T	c.(1303-1305)Ctc>Ttc	p.L435F	SLC6A13_ENST00000445055.2_Missense_Mutation_p.L343F|SLC6A13_ENST00000539668.1_5'UTR	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	435					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ACCTCTGTGAGCATGATCAGC	0.597000													10	87					0	0	1	0	0
GPATCH2	55105	broad.mit.edu	37	1	217784235	217784235	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:217784235T>A	ENST00000366935.3	-	4	1124	c.1014A>T	c.(1012-1014)agA>agT	p.R338S	GPATCH2_ENST00000366934.3_Missense_Mutation_p.R338S	NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	338						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		ACTGACCTCTTCTGCTTGGGT	0.403000													20	87					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220806	10220806	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr19:10220806G>T	ENST00000428358.1	+	8	878	c.706G>T	c.(706-708)Ggg>Tgg	p.G236W	PPAN_ENST00000556468.1_Missense_Mutation_p.G236W|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.G236W|PPAN_ENST00000393793.1_Missense_Mutation_p.G183W|PPAN_ENST00000253107.7_Missense_Mutation_p.G236W	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		236	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CAGGGGCGCGGGGCTGTCGGA	0.687000													10	51					0.00621372	0.00675475	1	1	0
BTN1A1	696	broad.mit.edu	37	6	26508767	26508767	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:26508767C>A	ENST00000244513.6	+	7	1012	c.946C>A	c.(946-948)Ctc>Atc	p.L316I		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	316	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						TCATCCCCACCTCTTTCTTTA	0.463000													38	231					2.66277e-13	4.70841e-13	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31424548	31424548	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:31424548A>T	ENST00000389202.2	+	16	2026	c.1977A>T	c.(1975-1977)aaA>aaT	p.K659N		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	659					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCATCCAGAAAAGCTCACTGG	0.612000													23	71					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150396264	150396264	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:150396264A>G	ENST00000295910.6	-	10	1241	c.1189T>C	c.(1189-1191)Ttt>Ctt	p.F397L	FAM194A_ENST00000491361.1_Missense_Mutation_p.F251L	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	397										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TGAAAATCAAATACAATGTCA	0.303000													6	49					0	0	1	0	0
FNDC8	54752	broad.mit.edu	37	17	33454273	33454273	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr17:33454273C>T	ENST00000158009.5	+	2	537	c.422C>T	c.(421-423)cCa>cTa	p.P141L		NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	141										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		GGCCCCTGCCCATGCCCATCG	0.572000													41	172					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209345829	209345829	+	Missense_Mutation	SNP	T	T	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:209345829T>G	ENST00000272847.2	+	10	1229	c.1016T>G	c.(1015-1017)gTt>gGt	p.V339G	AC019185.4_ENST00000424628.1_RNA|PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	339						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		ACGGTTAGAGTTCTAGCTACC	0.348000													10	38					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42872727	42872727	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr13:42872727G>T	ENST00000025301.2	+	7	585	c.410G>T	c.(409-411)aGg>aTg	p.R137M		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	137					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CCAAGACTTAGGATTGATTTT	0.358000													10	90					9.70103e-10	1.54916e-09	1	1	0
ANKMY1	51281	broad.mit.edu	37	2	241420372	241420372	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:241420372C>A	ENST00000391987.1	-	17	3127	c.2761G>T	c.(2761-2763)Ggg>Tgg	p.G921W	ANKMY1_ENST00000401804.1_Missense_Mutation_p.G1010W|ANKMY1_ENST00000373318.2_Missense_Mutation_p.G700W|ANKMY1_ENST00000373320.4_Missense_Mutation_p.G691W|ANKMY1_ENST00000361678.4_Missense_Mutation_p.G697W|ANKMY1_ENST00000403283.1_Missense_Mutation_p.G823W|ANKMY1_ENST00000272972.3_Missense_Mutation_p.G921W|ANKMY1_ENST00000406958.1_Missense_Mutation_p.G682W			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	921							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		ACCAGGTCCCCGCAGTCCTTC	0.677000													16	73					2.23348e-06	2.90282e-06	1	1	0
CCDC148	130940	broad.mit.edu	37	2	159028675	159028675	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:159028675G>T	ENST00000283233.5	-	14	2039	c.1726C>A	c.(1726-1728)Cct>Act	p.P576T	CCDC148_ENST00000409187.1_Missense_Mutation_p.P585T|CCDC148-AS1_ENST00000412781.2_RNA	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	576										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GGTTTTTGAGGACTAATTTTT	0.348000													9	64					2.17888e-05	2.72856e-05	1	1	0
NRD1	4898	broad.mit.edu	37	1	52280232	52280232	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:52280232delG	ENST00000354831.7	-	15	2003	c.1814delC	c.(1813-1815)cafs	p.P605fs	NRD1_ENST00000352171.7_Frame_Shift_Del_p.P537fs|NRD1_ENST00000539524.1_Frame_Shift_Del_p.P473fs|NRD1_ENST00000544028.1_Frame_Shift_Del_p.P405fs|NRD1_ENST00000485608.1_5'UTR	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	536					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						CCTTTTTTCTGGGCCTAGCTT	0.413													17	76	---	---	---	---					
FCRL4	83417	broad.mit.edu	37	1	157559231	157559232	+	Frame_Shift_Ins	INS	-	-	A			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:157559231_157559232insA	ENST00000271532.1	-	3	204_205	c.69_70insT	c.(67-72)cctgatfs	p.D24fs		NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	24	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				ACGGAAATCACAGGTTTGTGTG	0.495													8	46	---	---	---	---					
TNR	7143	broad.mit.edu	37	1	175331843	175331844	+	Frame_Shift_Ins	INS	-	-	G	rs150401432		TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:175331843_175331844insG	ENST00000367674.1	-	14	3517_3518	c.2809_2810insC	c.(2809-2811)gggfs	p.G937fs	TNR_ENST00000263525.2_Frame_Shift_Ins_p.G937fs	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	937	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.R937W(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTCCCTGCCCCGCACGCTGTTG	0.550													16	104	---	---	---	---					
KCNH1	3756	broad.mit.edu	37	1	210857394	210857395	+	Frame_Shift_Ins	INS	-	-	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr1:210857394_210857395insG	ENST00000367007.4	-	11	2286_2287	c.2117_2118insC	c.(2116-2118)cgafs	p.R706fs	KCNH1_ENST00000271751.4_Frame_Shift_Ins_p.R733fs	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	733	Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.P733P(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CAGGGTGGTCCGGGGGCAAGAT	0.579													24	63	---	---	---	---					
NCAPH	23397	broad.mit.edu	37	2	97017722	97017722	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr2:97017722delC	ENST00000455200.1	+	7	1136	c.841delC	c.(841-843)cafs	p.P281fs	NCAPH_ENST00000240423.4_Frame_Shift_Del_p.P292fs|NCAPH_ENST00000427946.1_Frame_Shift_Del_p.P156fs			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	292					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				TCTCGAGTTGCCAGAGTTAGG	0.453													9	105	---	---	---	---					
ARPP21	10777	broad.mit.edu	37	3	35785398	35785398	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:35785398delC	ENST00000187397.4	+	18	2429	c.1973delC	c.(1972-1974)gcfs	p.A658fs	ARPP21_ENST00000458225.1_Frame_Shift_Del_p.A659fs|ARPP21_ENST00000417925.1_Frame_Shift_Del_p.A659fs|ARPP21_ENST00000337271.5_Frame_Shift_Del_p.A639fs|ARPP21_ENST00000444190.1_Frame_Shift_Del_p.A639fs	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	658	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CGGCCCATGGCCCCGGTTCAG	0.502													18	114	---	---	---	---					
SLC9C1	285335	broad.mit.edu	37	3	111936360	111936361	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:111936360_111936361delTG	ENST00000305815.5	-	15	1970_1971	c.1718_1719delCA	c.(1717-1719)afs	p.T573fs	SLC9C1_ENST00000487372.1_Frame_Shift_Del_p.T525fs	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	573					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										CAAAGGTAACTGTTTTTTGGCT	0.302													9	52	---	---	---	---					
GPR149	344758	broad.mit.edu	37	3	154145374	154145374	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr3:154145374delG	ENST00000389740.2	-	2	1204	c.1105delC	c.(1105-1107)acfs	p.H369fs		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	369						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CAGGGCAAGTGGGTCCAGCGT	0.532													7	68	---	---	---	---					
HLA-F-AS1	285830	broad.mit.edu	37	6	29709409	29709410	+	RNA	INS	-	-	C			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr6:29709409_29709410insC	ENST00000458236.1	-	0	349																											gctgttagtttccccatttcat	0.441													2	4	---	---	---	---					
AEBP1	165	broad.mit.edu	37	7	44146399	44146399	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr7:44146399delC	ENST00000223357.3	+	2	813	c.508delC	c.(508-510)ccfs	p.P171fs		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	171	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						AGGGAAGAGGCCCCCCATTCT	0.657													11	19	---	---	---	---					
DAPK1	1612	broad.mit.edu	37	9	90321080	90321080	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:90321080delG	ENST00000469640.2	+	27	3544	c.3169delG	c.(3169-3171)tgfs	p.V1057fs	DAPK1_ENST00000472284.1_Frame_Shift_Del_p.V1032fs|DAPK1_ENST00000491893.1_Frame_Shift_Del_p.V966fs|DAPK1_ENST00000408954.3_Frame_Shift_Del_p.V1032fs|DAPK1_ENST00000358077.5_Frame_Shift_Del_p.V1032fs			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1032					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						AGTTCAGGACGTGCTGCTCCT	0.612									Chronic Lymphocytic Leukemia, Familial Clustering of				17	67	---	---	---	---					
OR13C2	392376	broad.mit.edu	37	9	107367862	107367862	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr9:107367862delC	ENST00000542196.1	-	1	89	c.47delG	c.(46-48)gafs	p.G16fs		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACCAGAAAGTCCCTTCAGAAA	0.373													12	51	---	---	---	---					
HOMEZ	57594	broad.mit.edu	37	14	23745440	23745440	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr14:23745440delG	ENST00000357460.5	-	2	1161	c.997delC	c.(997-999)aafs	p.Q333fs	HOMEZ_ENST00000561013.1_Frame_Shift_Del_p.Q335fs|HOMEZ_ENST00000431326.2_Frame_Shift_Del_p.Q335fs	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	333						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CGTAGCCCTTGGGGCCAGGCT	0.562													20	117	---	---	---	---					
MEX3B	84206	broad.mit.edu	37	15	82337679	82337679	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr15:82337679delC	ENST00000558133.1	-	1	781	c.368delG	c.(367-369)gafs	p.G123fs	MEX3B_ENST00000329713.4_Intron			Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	492	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CTTCCTCTCTCCCCAAGGCAC	0.687													2	4	---	---	---	---					
UNKL	64718	broad.mit.edu	37	16	1464642	1464643	+	Frame_Shift_Ins	INS	-	-	G			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:1464642_1464643insG	ENST00000389221.4	-	1	49_50	c.50_51insC	c.(49-51)ccafs	p.P17fs	UNKL_ENST00000508903.2_Frame_Shift_Ins_p.P17fs|UNKL_ENST00000397462.1_Frame_Shift_Ins_p.P17fs|UNKL_ENST00000503648.1_5'UTR|UNKL_ENST00000301712.5_Frame_Shift_Ins_p.P17fs	NM_001193388.1	NP_001180317.1	Q9H9P5	UNKL_HUMAN	unkempt family zinc finger-like	17						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Hepatocellular(780;0.0893)				TCTCAGTCTGCGGGGGGGACCC	0.757													2	4	---	---	---	---					
NPIPA5	100288332	broad.mit.edu	37	16	15457598	15457609	+	In_Frame_Del	DEL	GCTGAGGGTGGA	GCTGAGGGTGGA	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr16:15457598_15457609delGCTGAGGGTGGA	ENST00000360151.4	-	8	959_970	c.960_971delTCCACCCTCAGC	c.(958-972)gcg>gc	p.APPSA320del		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		ATTATCATCCGCTGAGGGTGGAGCTGAGGGTG	0.509													7	96	---	---	---	---					
VPS16	64601	broad.mit.edu	37	20	2845915	2845924	+	Frame_Shift_Del	DEL	ACAAGCGTGC	ACAAGCGTGC	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr20:2845915_2845924delACAAGCGTGC	ENST00000380445.3	+	21	2198_2207	c.2126_2135delACAAGCGTGC	c.(2125-2136)aafs	p.NKRA709fs	VPS16_ENST00000380443.3_Frame_Shift_Del_p.NKRA395fs|VPS16_ENST00000380469.3_Frame_Shift_Del_p.NKRA565fs|PTPRA_ENST00000380393.3_5'UTR	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	709					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						GGCGGTCACAACAAGCGTGCAGAGCAGCTG	0.610													16	73	---	---	---	---					
BCRP7	100133163	broad.mit.edu	37	22	18843613	18843613	+	RNA	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chr22:18843613delG	ENST00000412938.1	+	0	2337																											AGGAGAGGCAGGGGCGGGGGT	0.622													2	4	---	---	---	---					
SAGE1	55511	broad.mit.edu	37	X	134978488	134978488	+	Splice_Site	DEL	G	G	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:134978488delG	ENST00000535938.1	+	2	254	c.87_splice	c.e2+1	p.Q30_splice	SAGE1_ENST00000537770.1_Splice_Site_p.Q30_splice|SAGE1_ENST00000324447.3_Splice_Site_p.Q30_splice|SAGE1_ENST00000370709.3_Splice_Site_p.Q30_splice	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	30										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					ATGATGGGCAGGTAAGATAAC	0.373													14	26	---	---	---	---					
IL9R	3581	broad.mit.edu	37	X	155235049	155235049	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M7-01A-11D-A24P-08	TCGA-97-A4M7-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77909b63-e977-4ff9-941d-20fc6c01d87e	35d58aa1-b0d0-4f93-a5f9-12b48b93a467	g.chrX:155235049delC	ENST00000424344.3	+	7	990	c.623delC	c.(622-624)gcfs	p.A208fs	IL9R_ENST00000540897.1_Frame_Shift_Del_p.A254fs|IL9R_ENST00000244174.5_Frame_Shift_Del_p.A229fs|IL9R_ENST00000369423.2_Frame_Shift_Del_p.A264fs			Q01113	IL9R_HUMAN	interleukin 9 receptor	229	Fibronectin type-III.				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCCAGATGGCCACACTGGAG	0.577													20	79	---	---	---	---					
