Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL6A3	1293	broad.mit.edu	37	2	238247748	238247748	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr2:238247748A>T	ENST00000295550.4	-	39	8929	c.8477T>A	c.(8476-8478)tTt>tAt	p.F2826Y	COL6A3_ENST00000347401.3_Missense_Mutation_p.F2625Y|COL6A3_ENST00000346358.4_Missense_Mutation_p.F2626Y|COL6A3_ENST00000472056.1_Missense_Mutation_p.F2219Y|COL6A3_ENST00000409809.1_Missense_Mutation_p.F2620Y|COL6A3_ENST00000353578.4_Missense_Mutation_p.F2620Y	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2826	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGACAAGTAAAAAGCATTTTC	0.343000													8	38					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107798	55107798	+	Missense_Mutation	SNP	G	G	A	rs139338661	byFrequency	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:55107798G>A	ENST00000251372.3	+	7	1285	c.1103G>A	c.(1102-1104)cGt>cAt	p.R368H	LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	368	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GCCCCCCTCCGTCTCAGATCA	0.577000													12	68					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476574	17476574	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:17476574C>G	ENST00000252590.4	-	3	761	c.700G>C	c.(700-702)Gag>Cag	p.E234Q		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	234						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGGTCCATCTCAAACTTGTCC	0.587000													5	67					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126395236	126395236	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr10:126395236G>T	ENST00000337318.3	-	2	258	c.47C>A	c.(46-48)tCc>tAc	p.S16Y	FAM53B_ENST00000392754.3_Missense_Mutation_p.S16Y|FAM53B_ENST00000280780.6_Missense_Mutation_p.S16Y|RP11-464O2.2_ENST00000448422.2_RNA|RP11-12J10.3_ENST00000494792.1_3'UTR|RP11-464O2.2_ENST00000432699.1_RNA	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	16										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		ACATGCAATGGAGTCAGCTCC	0.577000													6	81					3.59834e-05	3.86292e-05	1	1	0
GNAS	2778	broad.mit.edu	37	20	57474035	57474035	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr20:57474035C>T	ENST00000371100.4	+	3	2733	c.2181C>T	c.(2179-2181)agC>agT	p.S727S	GNAS_ENST00000306090.10_Intron|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000354359.7_Silent_p.S84S|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000603534.1_Silent_p.S25S|GNAS_ENST00000371081.1_Silent_p.S84S|GNAS_ENST00000371102.4_Intron|GNAS_ENST00000371095.3_Intron|GNAS_ENST00000371098.2_3'UTR|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000605439.1_Silent_p.S25S|GNAS_ENST00000371085.3_Silent_p.S84S|GNAS_ENST00000265620.7_Intron	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	84					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGAGCAACAGCGATGGGTAGG	0.478000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			15	78					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155489647	155489647	+	Splice_Site	SNP	G	G	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr4:155489647G>T	ENST00000302068.4	+	5	895		c.e5+1		FGB_ENST00000509493.1_Splice_Site|FGB_ENST00000502545.1_Splice_Site	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GAAAATGGAGGTAAGCTTTCG	0.408000													8	83					0.0381472	0.0386771	1	1	0
EPRS	2058	broad.mit.edu	37	1	220192378	220192378	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr1:220192378C>T	ENST00000366923.3	-	11	1662	c.1393G>A	c.(1393-1395)Ggg>Agg	p.G465R		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	465	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ACTGTCATCCCTCTTCTCAGT	0.393000													23	76					0	0	1	0	0
MMP10	4319	broad.mit.edu	37	11	102650054	102650054	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr11:102650054A>G	ENST00000279441.4	-	3	422	c.386T>C	c.(385-387)gTt>gCt	p.V129A		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	129					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		GGCAGAATCAACAGCATCTCT	0.393000													7	111					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170501349	170501349	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr1:170501349C>T	ENST00000367763.3	+	1	80	c.60C>T	c.(58-60)tgC>tgT	p.C20C	GORAB_ENST00000367762.1_Silent_p.C20C|RP11-576I22.2_ENST00000456083.1_RNA	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	20						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						TTTGGGGGTGCCGGTGGCCCG	0.597000													4	48					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58126185	58126185	+	Missense_Mutation	SNP	G	G	A	rs142474037		TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr11:58126185G>A	ENST00000357377.3	-	1	357	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R120C(1)		NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCTGCGTAGCGGTCATAGGCC	0.473000													10	61					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16419598	16419598	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:16419598C>A	ENST00000380672.4	-	7	2746	c.2689G>T	c.(2689-2691)Gat>Tat	p.D897Y	BNC2_ENST00000380667.2_Missense_Mutation_p.D830Y|BNC2_ENST00000545497.1_Missense_Mutation_p.D802Y	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	897					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CCCATGTCATCGAGTTCTTTG	0.542000													18	61					1.02788e-11	1.17243e-11	1	1	0
OR2J2	26707	broad.mit.edu	37	6	29141532	29141532	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr6:29141532G>A	ENST00000377167.2	+	1	222	c.120G>A	c.(118-120)ctG>ctA	p.L40L		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGATGACACTGACAGGAAACC	0.423000													19	200					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114886607	114886607	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:114886607G>A	ENST00000374270.3	-	6	988	c.816C>T	c.(814-816)agC>agT	p.S272S	SUSD1_ENST00000374263.3_Silent_p.S272S|SUSD1_ENST00000482851.1_5'UTR|SUSD1_ENST00000374264.2_Silent_p.S272S	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	272	Sushi 2.					integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TTCCTCCAGGGCTCTCAAAGC	0.532000													37	82					0	0	1	0	0
IFNA5	3442	broad.mit.edu	37	9	21304862	21304862	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:21304862T>C	ENST00000259555.4	-	1	450	c.394A>G	c.(394-396)Act>Gct	p.T132A		NM_002169.2	NP_002160.1	P01569	IFNA5_HUMAN	interferon, alpha 5	132					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATCAGAGGAGTGTCTTCCACT	0.443000													59	167					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62049506	62049506	+	Missense_Mutation	SNP	T	T	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr17:62049506T>G	ENST00000578147.1	-	3	548	c.472A>C	c.(472-474)Aag>Cag	p.K158Q	SCN4A_ENST00000435607.1_Missense_Mutation_p.K158Q			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	158					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCCACATTCTTGGACCAGGGA	0.552000													4	11					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45433179	45433179	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr14:45433179C>G	ENST00000361462.2	+	1	1738	c.1555C>G	c.(1555-1557)Ctt>Gtt	p.L519V	KLHL28_ENST00000553817.1_5'UTR|FAM179B_ENST00000382233.2_Missense_Mutation_p.L519V|FAM179B_ENST00000361577.3_Missense_Mutation_p.L519V			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	519							binding	p.L519V(1)		endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						TGCCCCAGCTCTTGTAGATAG	0.478000													39	107					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962292	16962292	+	Missense_Mutation	SNP	A	A	G	rs61754499	byFrequency	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:16962292A>G	ENST00000379803.1	+	6	810	c.796A>G	c.(796-798)Agc>Ggc	p.S266G	SIN3B_ENST00000596802.1_Missense_Mutation_p.S266G|SIN3B_ENST00000248054.5_Missense_Mutation_p.S266G	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	266					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CCCGGAGCACAGCAGGAAGCG	0.662000													4	52					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37364387	37364387	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr5:37364387C>T	ENST00000231498.3	-	2	460	c.257G>A	c.(256-258)aGa>aAa	p.R86K	NUP155_ENST00000381843.2_Missense_Mutation_p.R27K|NUP155_ENST00000513532.1_Missense_Mutation_p.R86K	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	86					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGAGGAACTCTTCGGATGGA	0.388000													9	54					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66975426	66975426	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr16:66975426C>T	ENST00000317091.4	+	7	2109	c.1125C>T	c.(1123-1125)ccC>ccT	p.P375P	CES2_ENST00000417689.1_Silent_p.P375P	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	311					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGATGATCCCCGGAGTGGTGG	0.567000													18	49					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22095662	22095662	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chrX:22095662G>T	ENST00000379374.4	+	5	1070	c.505G>T	c.(505-507)Gtg>Ttg	p.V169L	PHEX_ENST00000537599.1_Missense_Mutation_p.V169L|PHEX_ENST00000535894.1_Missense_Mutation_p.V72L	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	169					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						CCGCTGGCCCGTGCTTGAATC	0.473000													9	235					0.00448238	0.00467448	1	1	0
NUGGC	389643	broad.mit.edu	37	8	27898690	27898690	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr8:27898690C>G	ENST00000413272.2	-	13	1631	c.1489G>C	c.(1489-1491)Gag>Cag	p.E497Q	NUGGC_ENST00000341513.6_Missense_Mutation_p.E497Q	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		TCAACCTTCTCTTCCGCAAAT	0.562000													2	4					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157246	22157246	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:22157246C>G	ENST00000397126.4	-	4	738	c.590G>C	c.(589-591)aGa>aCa	p.R197T	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGAATTCTCTCTAGTATAAAT	0.358000													6	43					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124380708	124380708	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr10:124380708G>A	ENST00000338354.3	+	41	5139	c.5033G>A	c.(5032-5034)tGc>tAc	p.C1678Y	DMBT1_ENST00000368956.2_Missense_Mutation_p.C1050Y|DMBT1_ENST00000368955.3_Missense_Mutation_p.C1668Y|DMBT1_ENST00000344338.3_Missense_Mutation_p.C1668Y|DMBT1_ENST00000330163.4_Missense_Mutation_p.C1050Y|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.C1678Y			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1678	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AATGTGGTCTGCAGGCAGCTG	0.627000													19	223					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15561403	15561403	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr21:15561403G>A	ENST00000344577.2	-	2	472	c.447C>T	c.(445-447)aaC>aaT	p.N149N	LIPI_ENST00000536861.1_Silent_p.N128N	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	128					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		CTTTTCTGGTGTTTTTAACTG	0.328000													8	23					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23191911	23191911	+	RNA	SNP	C	C	T	rs147199465	by1000genomes	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr15:23191911C>T	ENST00000400153.2	-	0	1785					NR_003521.1																						TGATTTTCTTCGCACTGATCC	0.408000													4	32					0	0	1	0	0
RAD52	5893	broad.mit.edu	37	12	1023154	1023154	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr12:1023154C>G	ENST00000358495.3	-	11	1239	c.1101G>C	c.(1099-1101)caG>caC	p.Q367H	RAD52_ENST00000430095.2_Missense_Mutation_p.Q367H|RAD52_ENST00000535376.1_5'UTR|RAD52_ENST00000539046.1_Missense_Mutation_p.Q290H	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	367					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			GAGTCCTGTTCTGGGTCACCA	0.537000								Homologous recombination					20	48					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090419	184090419	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr3:184090419G>A	ENST00000204615.7	-	6	1158	c.944C>T	c.(943-945)aCc>aTc	p.T315I	THPO_ENST00000445696.2_Missense_Mutation_p.T311I|THPO_ENST00000421442.2_Silent_p.H276H|EIF2B5_ENST00000444495.1_Intron	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	315	Pro-rich.				cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GACCACAGGGGTGGGCAAGGT	0.597000													11	88					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17353100	17353100	+	Missense_Mutation	SNP	C	C	T	rs142548093		TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr16:17353100C>T	ENST00000261381.6	-	3	742	c.658G>A	c.(658-660)Ggg>Agg	p.G220R		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	220					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCTCTGTCCCCGGGAGGCAGC	0.582000													25	101					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208729	58208729	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr13:58208729G>A	ENST00000377918.3	+	1	2075	c.2049G>A	c.(2047-2049)tcG>tcA	p.S683S		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	683	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCATCCGCTCGGTGAGCGGAT	0.632000													14	111					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410340	103410340	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr14:103410340G>A	ENST00000361246.2	-	30	4584	c.4296C>T	c.(4294-4296)ctC>ctT	p.L1432L		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1432	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CCTCGCTTTCGAGCTCCACAG	0.602000													8	48					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103553233	103553233	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr4:103553233G>T	ENST00000226578.4	-	17	2720	c.2621C>A	c.(2620-2622)tCc>tAc	p.S874Y	MANBA_ENST00000505239.1_Missense_Mutation_p.S817Y	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	874					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		ATCTGTTAAGGAGGTCACATG	0.418000													4	46					0.00909568	0.0093519	1	1	0
OR4C15	81309	broad.mit.edu	37	11	55322397	55322397	+	Silent	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr11:55322397C>G	ENST00000314644.2	+	1	615	c.615C>G	c.(613-615)ggC>ggG	p.G205G		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G205G(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GGACAGGGGGCCTCTTGCATT	0.468000										HNSCC(20;0.049)			4	69					0	0	1	0	0
HOXB7	3217	broad.mit.edu	37	17	46685369	46685369	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr17:46685369C>T	ENST00000239165.7	-	2	587	c.489G>A	c.(487-489)acG>acA	p.T163T	HOXB7_ENST00000567101.1_5'UTR	NM_004502.3	NP_004493.3	P09629	HXB7_HUMAN	homeobox B7	163						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.T163T(2)		NS(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	8						GCCGCCGCCGCGTCAGGTAGC	0.557000													17	51					0	0	1	0	0
CD274	29126	broad.mit.edu	37	9	5457194	5457194	+	Silent	SNP	T	T	C			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:5457194T>C	ENST00000381577.3	+	3	254	c.168T>C	c.(166-168)taT>taC	p.Y56Y	CD274_ENST00000498261.1_3'UTR|CD274_ENST00000381573.4_Intron	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	56	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		TAATTGTCTATTGGGAAATGG	0.423000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								13	38					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78522539	78522539	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr12:78522539G>A	ENST00000397909.2	+	18	4507	c.4334G>A	c.(4333-4335)cGt>cAt	p.R1445H	NAV3_ENST00000228327.6_Missense_Mutation_p.R1445H|NAV3_ENST00000536525.2_Missense_Mutation_p.R1445H|NAV3_ENST00000266692.7_Missense_Mutation_p.R1268H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1445	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GAGTGGTTGCGTTCTCATTCT	0.493000										HNSCC(70;0.22)			9	81					0	0	1	0	0
SUPT20H	55578	broad.mit.edu	37	13	37619511	37619511	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr13:37619511C>G	ENST00000360252.4	-	6	415	c.168G>C	c.(166-168)caG>caC	p.Q56H	SUPT20H_ENST00000356185.3_Missense_Mutation_p.Q56H|SUPT20H_ENST00000542180.1_Splice_Site|SUPT20H_ENST00000350612.6_Splice_Site|SUPT20H_ENST00000464744.1_Missense_Mutation_p.Q56H|SUPT20H_ENST00000470359.2_Splice_Site|SUPT20H_ENST00000475892.1_Splice_Site	NM_001278481.1|NM_001278482.1|NM_017569.3	NP_001265410.1|NP_001265411.1|NP_060039.1			suppressor of Ty 20 homolog (S. cerevisiae)																		TTCTTAATTTCTGCTTTAAAA	0.338000													4	28					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323058	31323058	+	Silent	SNP	T	T	C	rs146257998	byFrequency	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr5:31323058T>C	ENST00000265071.2	+	12	2281	c.2016T>C	c.(2014-2016)ttT>ttC	p.F672F		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	672					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCCAGGCTTTTGATATCGGCA	0.488000													4	73					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286804	57286804	+	Missense_Mutation	SNP	G	G	A	rs149106731		TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:57286804G>A	ENST00000391708.3	-	12	1378	c.836C>T	c.(835-837)cCg>cTg	p.P279L	ZIM2_ENST00000221722.5_Missense_Mutation_p.P279L|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000593711.1_Missense_Mutation_p.P279L|ZIM2_ENST00000601070.1_Missense_Mutation_p.P279L|ZIM2_ENST00000599935.1_Missense_Mutation_p.P279L|AC006115.3_ENST00000595954.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		GCTTCTTTCCGGAGTGAGGGT	0.458000													28	62					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42858801	42858801	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:42858801C>T	ENST00000334370.4	+	22	4507	c.3872C>T	c.(3871-3873)tCg>tTg	p.S1291L	MEGF8_ENST00000251268.6_Missense_Mutation_p.S1358L	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1358	CUB 2.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTTGTCCAGTCGGACCGCAGC	0.607000													19	174					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48584693	48584693	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr4:48584693G>A	ENST00000358350.4	-	20	2411	c.1807C>T	c.(1807-1809)Cta>Tta	p.L603L	FRYL_ENST00000503238.1_Silent_p.L603L|FRYL_ENST00000507711.1_Silent_p.L603L|FRYL_ENST00000506685.1_Silent_p.L309L|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000537810.1_Silent_p.L603L	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TCAAGCATTAGTGCCTGCAGA	0.398000													21	61					0	0	1	0	0
RIT1	6016	broad.mit.edu	37	1	155870346	155870346	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr1:155870346C>A	ENST00000368323.3	-	6	697	c.493G>T	c.(493-495)Gct>Tct	p.A165S	RIT1_ENST00000368322.3_Missense_Mutation_p.A182S|RIT1_ENST00000461050.1_5'UTR|RIT1_ENST00000539040.1_Missense_Mutation_p.A129S	NM_006912.5	NP_008843.1	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	165					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|skin(1)|urinary_tract(1)	19	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			CGGTATGCAGCAGATGTCTCA	0.433000													9	160					2.74318e-10	3.0808e-10	1	1	0
AFAP1L2	84632	broad.mit.edu	37	10	116056777	116056777	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr10:116056777A>G	ENST00000369271.3	-	18	2678	c.2378T>C	c.(2377-2379)gTc>gCc	p.V793A	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.V797A|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.V850A|AFAP1L2_ENST00000491814.1_5'UTR	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	797					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TGTGACCACGACCGAGAGAGG	0.572000													10	61					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144086413	144086413	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr6:144086413C>T	ENST00000427704.2	+	6	807	c.677C>T	c.(676-678)tCa>tTa	p.S226L	PHACTR2_ENST00000367582.3_Missense_Mutation_p.S157L|PHACTR2_ENST00000440869.2_Missense_Mutation_p.S237L|PHACTR2_ENST00000305766.6_Missense_Mutation_p.S146L|PHACTR2_ENST00000367584.4_Missense_Mutation_p.S214L	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	226							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TCCTCTCATTCAAAAAAAACA	0.398000													6	99					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21206993	21206993	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:21206993C>G	ENST00000357374.2	-	1	149	c.104G>C	c.(103-105)aGg>aCg	p.R35T		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	35					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		CAAGGCCCTCCTATTACCCAG	0.517000													24	102					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44030317	44030317	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr18:44030317G>A	ENST00000269439.7	+	5	725	c.674G>A	c.(673-675)gGa>gAa	p.G225E	RNF165_ENST00000543885.1_Missense_Mutation_p.G33E	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	225							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GCTCTCCAGGGACTAAATCCC	0.502000													4	39					0	0	1	0	0
VPS9D1	9605	broad.mit.edu	37	16	89776218	89776218	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr16:89776218G>C	ENST00000561976.1	-	10	1522	c.1145C>G	c.(1144-1146)tCc>tGc	p.S382C	VPS9D1_ENST00000389386.3_Missense_Mutation_p.S452C					VPS9 domain containing 1																		CCACAGCGGGGAGAAAAAGGG	0.622000													4	54					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100912444	100912444	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chrX:100912444C>T	ENST00000328766.5	-	5	584	c.131G>A	c.(130-132)cGg>cAg	p.R44Q	ARMCX2_ENST00000356824.4_Missense_Mutation_p.R44Q|ARMCX2_ENST00000330154.2_Missense_Mutation_p.R44Q|ARMCX2_ENST00000467416.1_5'UTR	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	44						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						agccacagcccGGTTTTTGGG	0.592000													13	42					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45452190	45452190	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr17:45452190G>A	ENST00000331493.2	+	12	1641	c.1230G>A	c.(1228-1230)ttG>ttA	p.L410L	EFCAB13_ENST00000517484.1_Silent_p.L314L	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		CACAAAGCTTGAAGAGTAGTA	0.368000													5	42					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60911825	60911825	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr20:60911825C>A	ENST00000252999.3	-	17	2248	c.2182G>T	c.(2182-2184)Gcc>Tcc	p.A728S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	728	Laminin EGF-like 9.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCAGACCGGCAGGGTGGCAA	0.627000													8	30					1.12685e-05	1.22776e-05	1	1	0
ASCC1	51008	broad.mit.edu	37	10	73912659	73912659	+	Silent	SNP	G	G	A	rs138245920	byFrequency	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr10:73912659G>A	ENST00000342444.4	-	8	899	c.798C>T	c.(796-798)taC>taT	p.Y266Y	ASCC1_ENST00000394919.1_Silent_p.Y238Y|ASCC1_ENST00000317126.4_Silent_p.Y238Y|ASCC1_ENST00000394915.3_Silent_p.Y266Y|ASCC1_ENST00000545550.1_Silent_p.Y260Y|ASCC1_ENST00000317168.6_Silent_p.Y238Y	NM_001198799.2	NP_001185728.1	Q8N9N2	ASCC1_HUMAN	activating signal cointegrator 1 complex subunit 1	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding			endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(2)|skin(1)	7						GGACTTTGGCGTAAAGAACAT	0.408000													3	38					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274518	39274518	+	Missense_Mutation	SNP	C	C	T	rs9897031	by1000genomes	TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr17:39274518C>T	ENST00000391413.2	-	1	88	c.50G>A	c.(49-51)cGa>cAa	p.R17Q		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	17	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].			R -> Q (in Ref. 1; CAC27583 and 3; AAI26132/AAI30563).		keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGAGGTCTCGGCCACAGCC	0.592000													3	21					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15134073	15134073	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr11:15134073C>G	ENST00000379554.3	+	1	104	c.58C>G	c.(58-60)Cta>Gta	p.L20V		NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	20					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						TGGCTGGGGTCTATGGGGAGT	0.597000													7	14					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151277195	151277195	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr6:151277195C>T	ENST00000367321.3	+	17	2065	c.1791C>T	c.(1789-1791)ggC>ggT	p.G597G		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	597	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		CAGAGAAGGGCCATTACCGGC	0.463000													6	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498611	179498611	+	Silent	SNP	C	C	T			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr2:179498611C>T	ENST00000589042.1	-	231	42839	c.42615G>A	c.(42613-42615)ttG>ttA	p.L14205L	TTN_ENST00000460472.2_Silent_p.L5140L|TTN_ENST00000591111.1_Silent_p.L12564L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Silent_p.L5265L|TTN_ENST00000342175.6_Silent_p.L5332L|TTN_ENST00000342992.6_Silent_p.L11637L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12564	Fibronectin type-III 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATATCATCCAATGTCACTT	0.408000													14	184					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038503	131038503	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr9:131038503G>C	ENST00000320188.4	+	1	79	c.79G>C	c.(79-81)Gag>Cag	p.E27Q		NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)	27					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										CCCACCTCGGGAGAGGGGCGG	0.682000													5	40					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100374015	100374015	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr14:100374015A>G	ENST00000262233.6	+	10	1188	c.1049A>G	c.(1048-1050)gAc>gGc	p.D350G	EML1_ENST00000334192.4_Missense_Mutation_p.D369G|EML1_ENST00000327921.9_Missense_Mutation_p.D338G	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	350						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GACTCCAACGACCATGTGCTC	0.418000													11	38					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47299967	47299967	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr17:47299967G>A	ENST00000225941.1	+	8	1489	c.991G>A	c.(991-993)Gag>Aag	p.E331K	ABI3_ENST00000419580.2_Missense_Mutation_p.E325K	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	331	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CTCCTTCTCTGAGGGCACTGT	0.577000										HNSCC(55;0.14)			5	36					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176960	140176960	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr5:140176960C>A	ENST00000378132.1	+	1	2517	c.2411C>A	c.(2410-2412)gCc>gAc	p.A804D	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_031495.1	NP_113683.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTTTCTTGCCAATTCTAAA	0.343000													7	34					0.00198382	0.00209882	1	1	0
FAM69C	125704	broad.mit.edu	37	18	72109265	72109265	+	Silent	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr18:72109265G>A	ENST00000343998.6	-	3	971	c.963C>T	c.(961-963)tgC>tgT	p.C321C	FAM69C_ENST00000400291.2_Silent_p.C22C	NM_001044369.2	NP_001037834.2	Q0P6D2	FA69C_HUMAN	family with sequence similarity 69, member C	321						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(2)|ovary(2)	5						CAAAGAAATTGCAGTCTTCAT	0.448000													6	47					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496270	9496270	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr20:9496270G>A	ENST00000246070.2	+	2	727	c.235G>A	c.(235-237)Gat>Aat	p.D79N	LAMP5_ENST00000427562.2_Missense_Mutation_p.D79N	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	79						integral to membrane											CAACTACGTAGATGTAAGGAA	0.527000													14	54					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185984321	185984321	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr1:185984321C>A	ENST00000271588.4	+	31	4890	c.4661C>A	c.(4660-4662)aCc>aAc	p.T1554N	HMCN1_ENST00000367492.2_Missense_Mutation_p.T1554N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1554	Ig-like C2-type 13.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGAAATGTCACCACAGACATA	0.388000													9	44					7.48243e-07	8.27602e-07	1	1	0
TRDV1	28518	broad.mit.edu	37	14	22564882	22564882	+	RNA	SNP	T	T	A			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr14:22564882T>A	ENST00000390452.2	+	0	351																											AGTACTTTTGTGCTCTTGGGG	0.433000													3	33					0	0	1	0	0
LOC100129620	100129620	broad.mit.edu	37	1	99474094	99474094	+	RNA	DEL	A	A	-	rs57656522		TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr1:99474094delA	ENST00000425113.1	+	0	370					NR_033940.1																						AACAGCAACTAAAAAAAAAAA	0.353													3	4	---	---	---	---					
MET	4233	broad.mit.edu	37	7	116412043	116412043	+	Splice_Site	DEL	G	G	-			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr7:116412043delG	ENST00000397752.3	+	14	3228	c.3028_splice	c.e14+1	p.D1010_splice	MET_ENST00000318493.6_Splice_Site_p.D1028_splice	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1010		Breakpoint for translocation to form TPR- MET oncogene.			axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.L982_D1028del(3)|p.D981_D1028del(1)|p.982_1028del47(1)|p.?(1)		NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTTTCCAGAAGGTATATTTCA	0.348			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				13	22	---	---	---	---					
RB1	5925	broad.mit.edu	37	13	48919276	48919277	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr13:48919276_48919277delTA	ENST00000267163.4	+	4	579_580	c.441_442delTA	c.(439-444)gctgfs	p.AM147fs		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	147					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.M148fs*9(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGATAATGCTATGTCAAGACT	0.287		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			11	34	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20262849	20262850	+	RNA	INS	-	-	T	rs142097873		TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chr19:20262849_20262850insT	ENST00000593655.1	-	0	337				CTC-260E6.6_ENST00000586657.1_RNA																							TTTCttttttcttttttttttt	0.470													3	5	---	---	---	---					
MECP2	4204	broad.mit.edu	37	X	153363100	153363102	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-J2-A4AE-01A-21D-A24D-08	TCGA-J2-A4AE-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6f1e76-c6ac-4651-9b36-f74ef6a7faca	9eede9a8-25a8-435e-b25a-8a4eb7d3aa81	g.chrX:153363100_153363102delGCG	ENST00000453960.2	-	1	75_77	c.21_23delCGC	c.(19-24)gcg>gc	p.AA7del	MECP2_ENST00000303391.6_5'UTR|MECP2_ENST00000407218.1_5'UTR	NM_001110792.1	NP_001104262.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	0					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCGCTCGGCgcggcggcggcgg	0.778													2	4	---	---	---	---					
