Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM83B	222584	broad.mit.edu	37	6	54806409	54806409	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:54806409G>T	ENST00000306858.7	+	5	2756	c.2640G>T	c.(2638-2640)agG>agT	p.R880S		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	880										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TCTTGGAAAGGGCAGGAGATG	0.428000													13	61					1.5842e-08	1.97396e-08	1	1	0
ZNF282	8427	broad.mit.edu	37	7	148921513	148921513	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr7:148921513C>T	ENST00000262085.3	+	8	1895	c.1790C>T	c.(1789-1791)aCg>aTg	p.T597M	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	597					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCTGCACACGGGCGAGCGG	0.642000													7	39					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38800295	38800295	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr4:38800295G>A	ENST00000308979.2	-	4	431	c.158C>T	c.(157-159)tCg>tTg	p.S53L	TLR1_ENST00000502213.2_Missense_Mutation_p.S53L	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	53					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						ATAATTTTGCGATATATTTAA	0.318000													19	119					0	0	1	0	0
CENPL	91687	broad.mit.edu	37	1	173780306	173780306	+	Silent	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:173780306T>A	ENST00000356198.2	-	3	417	c.132A>T	c.(130-132)ccA>ccT	p.P44P	CENPL_ENST00000367710.3_Silent_p.P44P|CENPL_ENST00000345664.6_Silent_p.P44P	NM_001127181.2	NP_001120653.1	Q8N0S6	CENPL_HUMAN	centromere protein L	44					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(3)	11						TCCTTCGAGGTGGAGTCAGGA	0.418000													22	108					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21805251	21805251	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr10:21805251C>A	ENST00000449193.2	-	4	3753	c.1501G>T	c.(1501-1503)Gat>Tat	p.D501Y	SKIDA1_ENST00000444772.3_Missense_Mutation_p.D422Y	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		CTGCCGGCATCCTCGAAAGCA	0.632000													6	62					8.12818e-05	9.05053e-05	1	1	0
RTN2	6253	broad.mit.edu	37	19	45998092	45998092	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:45998092C>T	ENST00000245923.4	-	3	486	c.251G>A	c.(250-252)cGc>cAc	p.R84H	RTN2_ENST00000590526.1_5'UTR|RTN2_ENST00000344680.4_Missense_Mutation_p.R84H|PPM1N_ENST00000401705.1_Intron|RTN2_ENST00000589384.1_5'UTR	NM_005619.4	NP_005610.1	O75298	RTN2_HUMAN	reticulon 2	84						integral to endoplasmic reticulum membrane	signal transducer activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(4)|skin(1)|urinary_tract(1)	20		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GCGGGGGCGGCGGGCAGTTGA	0.687000													6	47					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58349450	58349450	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:58349450A>G	ENST00000371015.1	+	7	1546	c.1079A>G	c.(1078-1080)gAg>gGg	p.E360G	PHACTR3_ENST00000541461.1_Missense_Mutation_p.E319G|PHACTR3_ENST00000395636.2_Missense_Mutation_p.E319G|PHACTR3_ENST00000395639.4_Missense_Mutation_p.E249G|PHACTR3_ENST00000361300.4_Missense_Mutation_p.E249G|PHACTR3_ENST00000359926.3_Missense_Mutation_p.E357G|PHACTR3_ENST00000355648.4_Missense_Mutation_p.E319G	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	360						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AAGGAATCTGAGGAGAACAAG	0.522000													14	75					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228384687	228384687	+	Silent	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:228384687A>T	ENST00000310078.7	+	3	545	c.285A>T	c.(283-285)ggA>ggT	p.G95G	AGFG1_ENST00000409979.2_Silent_p.G95G|AGFG1_ENST00000373671.3_Silent_p.G95G|AGFG1_ENST00000409171.1_Silent_p.G95G|AGFG1_ENST00000486932.1_3'UTR|AGFG1_ENST00000409315.1_Silent_p.G95G	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	95	Arf-GAP.				cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						TTTGGCTAGGATTATTTGATG	0.308000													26	67					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52366197	52366197	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:52366197G>C	ENST00000420323.2	+	8	1334	c.1073G>C	c.(1072-1074)cGg>cCg	p.R358P		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	358	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGGTGCCACGGATCCAGCTT	0.597000													3	7					0	0	1	0	0
IL34	146433	broad.mit.edu	37	16	70690952	70690952	+	Silent	SNP	C	C	G	rs142587592	byFrequency	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr16:70690952C>G	ENST00000429149.2	+	5	885	c.330C>G	c.(328-330)ctC>ctG	p.L110L	IL34_ENST00000566361.1_Silent_p.L85L|IL34_ENST00000288098.2_Silent_p.L110L	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34	110					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						ACGTGCTGCTCGAGGGCCACC	0.637000													6	103					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142145685	142145685	+	Splice_Site	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:142145685T>A	ENST00000264951.4	-	3	426		c.e3-2		XRN1_ENST00000392981.2_Splice_Site|XRN1_ENST00000463916.1_Splice_Site|XRN1_ENST00000544157.1_Intron	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TTTGCTGACCTTAAAGGTTAA	0.353000													14	85					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150068670	150068670	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr7:150068670C>G	ENST00000397281.2	+	4	829	c.340C>G	c.(340-342)Ctg>Gtg	p.L114V	REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000482680.1_3'UTR|REPIN1_ENST00000425389.2_Missense_Mutation_p.L114V|REPIN1_ENST00000466559.1_3'UTR|REPIN1_ENST00000489432.2_Missense_Mutation_p.L171V|REPIN1_ENST00000444957.1_Missense_Mutation_p.L114V|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000540729.1_Missense_Mutation_p.L114V	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	114					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CACCCCAGACCTGGGCTTTGC	0.672000													4	12					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49881252	49881252	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:49881252C>A	ENST00000331456.2	-	5	503	c.390G>T	c.(388-390)atG>atT	p.M130I	TRAIP_ENST00000469027.1_Intron	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	130					cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGAGCACAGCATCTCGGCCT	0.527000													18	92					1.01871e-10	1.36699e-10	1	1	0
PHACTR3	116154	broad.mit.edu	37	20	58349430	58349430	+	Silent	SNP	A	A	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:58349430A>C	ENST00000371015.1	+	7	1526	c.1059A>C	c.(1057-1059)cgA>cgC	p.R353R	PHACTR3_ENST00000541461.1_Silent_p.R312R|PHACTR3_ENST00000395636.2_Silent_p.R312R|PHACTR3_ENST00000395639.4_Silent_p.R242R|PHACTR3_ENST00000361300.4_Silent_p.R242R|PHACTR3_ENST00000359926.3_Silent_p.R350R|PHACTR3_ENST00000355648.4_Silent_p.R312R	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	353						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AGAACAAGCGAACTGCCGCTA	0.542000													8	63					0	0	1	0	0
NKAP	79576	broad.mit.edu	37	X	119077245	119077245	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:119077245G>T	ENST00000371410.3	-	1	490	c.324C>A	c.(322-324)taC>taA	p.Y108*		NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	108					negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						TGTCGCTCCCGTAGGGGCGCG	0.642000													11	48					9.70103e-10	1.24841e-09	1	1	0
TARBP1	6894	broad.mit.edu	37	1	234541755	234541755	+	Nonsense_Mutation	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:234541755T>A	ENST00000040877.1	-	24	3882	c.3883A>T	c.(3883-3885)Aag>Tag	p.K1295*	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1295					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CAGAGTTTCTTAAGAGCAACT	0.408000													24	90					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194118596	194118596	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:194118596T>C	ENST00000401815.1	-	1	487	c.416A>G	c.(415-417)cAa>cGa	p.Q139R	GP5_ENST00000323007.3_Missense_Mutation_p.Q139R			P40197	GPV_HUMAN	glycoprotein V (platelet)	139					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		AAACATGTTTTGGTCAATGCC	0.502000													19	62					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75836172	75836172	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:75836172G>A	ENST00000322507.8	-	39	6664	c.6355C>T	c.(6355-6357)Cct>Tct	p.P2119S	COL12A1_ENST00000345356.6_Missense_Mutation_p.P955S|COL12A1_ENST00000483888.2_Missense_Mutation_p.P2119S|COL12A1_ENST00000416123.2_Missense_Mutation_p.P2119S	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2119	Fibronectin type-III 17.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ATGTTCTGAGGAGGAAGGAGT	0.418000													19	75					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													4	65					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48888919	48888919	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:48888919C>A	ENST00000315869.7	-	9	1536	c.1277G>T	c.(1276-1278)cGa>cTa	p.R426L	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	426	Leucine-zipper.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						AACCTGAATTCGGAGCTGCAG	0.607000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								6	13					0.000157383	0.000174008	1	1	0
EIF2AK3	9451	broad.mit.edu	37	2	88861822	88861822	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:88861822C>A	ENST00000303236.3	-	15	3373	c.3072G>T	c.(3070-3072)caG>caT	p.Q1024H	AC104134.2_ENST00000413234.1_RNA|EIF2AK3_ENST00000419748.1_Missense_Mutation_p.Q873H	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	1024	Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CTCTCTCCATCTGAGTGCTGA	0.343000													6	51					0.00116845	0.00124793	1	1	0
NTNG2	84628	broad.mit.edu	37	9	135116406	135116406	+	Silent	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr9:135116406G>A	ENST00000393229.3	+	7	2108	c.1332G>A	c.(1330-1332)acG>acA	p.T444T	NTNG2_ENST00000490694.1_3'UTR|NTNG2_ENST00000393228.4_Silent_p.T436T|NTNG2_ENST00000360670.3_Silent_p.T450T	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	444	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GCCTCCCCACGCACTACTGGC	0.741000													4	12					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2333334	2333334	+	Nonsense_Mutation	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr16:2333334A>T	ENST00000301732.5	-	26	4588	c.3888T>A	c.(3886-3888)taT>taA	p.Y1296*	ABCA3_ENST00000382381.3_Nonsense_Mutation_p.Y1238*	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1296					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CGCTCCAGGCATAGAAGTTCT	0.667000													7	30					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21771605	21771605	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:21771605G>T	ENST00000318249.5	+	2	376	c.26G>T	c.(25-27)gGc>gTc	p.G9V	NBPF3_ENST00000478653.2_3'UTR|NBPF3_ENST00000454000.2_Missense_Mutation_p.G9V|NBPF3_ENST00000342104.5_Missense_Mutation_p.G9V|NBPF3_ENST00000318220.6_5'UTR	NM_032264.3	NP_115640.1	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	9						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACTGTCCAGGGCTTCCAGTGG	0.587000													7	26					0.00198382	0.00209033	1	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47075159	47075159	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr17:47075159T>A	ENST00000290341.3	+	1	386	c.52T>A	c.(52-54)Ttg>Atg	p.L18M	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.L18M|IGF2BP1_ENST00000515586.1_3'UTR	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	18	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CCCCGCGGACTTGGAGAAAGT	0.622000													16	56					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963465	88963465	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr7:88963465T>A	ENST00000333190.4	+	4	1778	c.1169T>A	c.(1168-1170)cTg>cAg	p.L390Q		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	390						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTTCATCACTGGAGCCAAGT	0.388000										HNSCC(36;0.09)			6	41					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107369381	107369381	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:107369381G>T	ENST00000372232.3	+	2	244	c.85G>T	c.(85-87)Gta>Tta	p.V29L	ATG4A_ENST00000545696.1_5'UTR|ATG4A_ENST00000345734.3_Missense_Mutation_p.V29L|ATG4A_ENST00000372254.3_Missense_Mutation_p.V29L	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	29					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						AGATGAGCTGGTATGGATCTT	0.388000													11	39					4.36969e-10	5.76505e-10	1	1	0
RELN	5649	broad.mit.edu	37	7	103294578	103294578	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr7:103294578G>T	ENST00000428762.1	-	13	1675	c.1516C>A	c.(1516-1518)Cat>Aat	p.H506N	RELN_ENST00000424685.2_Missense_Mutation_p.H506N|RELN_ENST00000343529.5_Missense_Mutation_p.H506N	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	506					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGTGTTATATGCTCTTTTCTT	0.403000													9	65					0.000442599	0.000479228	1	1	0
DIP2B	57609	broad.mit.edu	37	12	51097973	51097973	+	Silent	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr12:51097973C>T	ENST00000301180.5	+	20	2410	c.2376C>T	c.(2374-2376)atC>atT	p.I792I		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	792			I -> V (in dbSNP:rs11169525).			nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						TGCCATTCATCCGATCAGGAT	0.388000													12	68					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137206498	137206498	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:137206498C>A	ENST00000239926.4	+	2	532	c.158C>A	c.(157-159)tCt>tAt	p.S53Y	MYOT_ENST00000509812.1_Intron|MYOT_ENST00000515645.1_Intron|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000421631.2_Intron	NM_006790.2	NP_006781.1	Q9UBF9	MYOTI_HUMAN	myotilin	53					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAAAGATTTTCTGCCTCCTCA	0.532000													46	117					6.68952e-21	9.63536e-21	1	1	0
BHLHE41	79365	broad.mit.edu	37	12	26276042	26276042	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr12:26276042G>A	ENST00000242728.4	-	5	753	c.406C>T	c.(406-408)Caa>Taa	p.Q136*		NM_030762.2	NP_110389.1	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix family, member e41	136	Orange.				cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(1)	5						GCGCATGTTTGAAATCCCGAG	0.582000											OREG0021711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	1	0	0
MSTN	2660	broad.mit.edu	37	2	190922057	190922057	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:190922057T>C	ENST00000260950.4	-	3	1187	c.1055A>G	c.(1054-1056)tAt>tGt	p.Y352C	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	352					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			GCCATTAAAATATAGCATATT	0.403000													14	53					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329269	56329269	+	Splice_Site	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:56329269C>T	ENST00000443188.1	-	4	982		c.e4+1		NLRP11_ENST00000589093.1_Splice_Site|NLRP11_ENST00000592953.1_Intron|NLRP11_ENST00000360133.3_Splice_Site|NLRP11_ENST00000589824.2_Splice_Site	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11								ATP binding	p.?(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACCCCACTCACGGTTTCGTCT	0.423000													40	66					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50719544	50719544	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr22:50719544C>T	ENST00000449103.1	-	23	3877	c.3737G>A	c.(3736-3738)cGg>cAg	p.R1246Q	PLXNB2_ENST00000359337.4_Missense_Mutation_p.R1246Q			O15031	PLXB2_HUMAN	plexin B2	1246					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCAGCGGTCCCGCACGCTCTC	0.657000													4	12					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221054572	221054572	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:221054572G>T	ENST00000366903.6	+	2	2130	c.629G>T	c.(628-630)gGg>gTg	p.G210V		NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	210					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		CGGCCCGCCGGGGTGCACCTC	0.582000													46	125					2.81731e-22	4.09553e-22	1	1	0
USP9X	8239	broad.mit.edu	37	X	41056749	41056749	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:41056749G>A	ENST00000324545.7	+	29	4999	c.4366G>A	c.(4366-4368)Gct>Act	p.A1456T	USP9X_ENST00000378308.2_Missense_Mutation_p.A1456T	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1456					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						AAAAGGAGGTGCTAATCTCAT	0.328000													5	45					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137753202	137753202	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:137753202C>A	ENST00000314358.5	+	13	3538	c.3338C>A	c.(3337-3339)gCt>gAt	p.A1113D	KDM3B_ENST00000542866.1_Missense_Mutation_p.A145D|KDM3B_ENST00000394866.1_Missense_Mutation_p.A769D	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1113					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						ATGGTACATGCTGCCCGGGGC	0.418000													7	77					2.0095e-06	2.37211e-06	1	1	0
USH2A	7399	broad.mit.edu	37	1	215901478	215901478	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:215901478T>C	ENST00000366943.2	-	61	12346	c.11960A>G	c.(11959-11961)aAg>aGg	p.K3987R	USH2A_ENST00000307340.3_Missense_Mutation_p.K3987R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3987	Fibronectin type-III 25.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGATTCTGGCTTTGTCCAATT	0.488000										HNSCC(13;0.011)			43	102					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43572113	43572113	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr15:43572113G>A	ENST00000452443.2	-	10	1392	c.1388C>T	c.(1387-1389)tCt>tTt	p.S463F		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	463					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CATTTTCCGAGAAGCCTTCAT	0.577000													17	72					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39325070	39325070	+	Silent	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:39325070T>C	ENST00000287152.7	-	19	2257	c.2163A>G	c.(2161-2163)caA>caG	p.Q721Q	KIF6_ENST00000373215.3_Silent_p.Q704Q|KIF6_ENST00000394362.1_Silent_p.Q172Q|KIF6_ENST00000373216.3_Silent_p.Q721Q|KIF6_ENST00000373213.4_Silent_p.Q560Q|KIF6_ENST00000229913.5_Silent_p.Q172Q|KIF6_ENST00000538893.1_Silent_p.Q665Q|KIF6_ENST00000541946.1_Silent_p.Q172Q	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	721					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TAGAGAGGAGTTGGGACCATT	0.483000													14	63					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577545	92577545	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:92577545G>A	ENST00000298047.6	+	18	11029	c.11012G>A	c.(11011-11013)cGc>cAc	p.R3671H	FAT3_ENST00000409404.2_Missense_Mutation_p.R3671H|FAT3_ENST00000533797.1_Missense_Mutation_p.R6H|FAT3_ENST00000525166.1_Missense_Mutation_p.R3521H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3671					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGGTTCCGGCGCACCCTGCGG	0.587000										TCGA Ovarian(4;0.039)			7	37					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140055651	140055651	+	Splice_Site	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr9:140055651T>A	ENST00000371561.3	+	9	2436		c.e9+2		GRIN1_ENST00000371553.3_Splice_Site|GRIN1_ENST00000471122.1_Splice_Site|GRIN1_ENST00000371550.4_Splice_Site|GRIN1_ENST00000371546.4_Splice_Site|GRIN1_ENST00000371559.4_Splice_Site|GRIN1_ENST00000371555.4_Splice_Site|GRIN1_ENST00000315048.3_Splice_Site|GRIN1_ENST00000350902.5_Splice_Site|GRIN1_ENST00000371560.3_Splice_Site	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1						ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGGCAGCCGTGAGTGCgcgg	0.716000													5	6					0	0	1	0	0
ZNF782	158431	broad.mit.edu	37	9	99581808	99581808	+	Missense_Mutation	SNP	T	T	C	rs140237274		TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr9:99581808T>C	ENST00000481138.1	-	6	1158	c.497A>G	c.(496-498)aAt>aGt	p.N166S	ZNF782_ENST00000466833.1_5'UTR|ZNF782_ENST00000535338.1_Missense_Mutation_p.N34S	NM_001001662.1	NP_001001662.1	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				GTCACAAACATTACGCTCATG	0.433000													12	62					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46544074	46544074	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr13:46544074G>A	ENST00000242848.4	-	14	2953	c.2605C>T	c.(2605-2607)Cga>Tga	p.R869*	ZC3H13_ENST00000282007.3_Nonsense_Mutation_p.R869*			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	869							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTTGAGGTCGTACAACTTGG	0.418000													27	112					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53661217	53661217	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:53661217C>T	ENST00000342160.3	-	7	995	c.538G>A	c.(538-540)Gca>Aca	p.A180T	HUWE1_ENST00000262854.6_Missense_Mutation_p.A180T|HUWE1_ENST00000218328.8_Missense_Mutation_p.A180T			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	180					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CAACATTCTGCAAGTCCAAAG	0.448000													18	80					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65559053	65559053	+	Silent	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr15:65559053C>T	ENST00000261888.6	-	3	811	c.366G>A	c.(364-366)ccG>ccA	p.P122P	PARP16_ENST00000558873.1_5'UTR|PARP16_ENST00000444347.2_Intron	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	122	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						ACAGGAAGTCCGGTGCAGGAA	0.443000													4	25					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103015	168103015	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:168103015C>A	ENST00000409195.1	+	9	5202	c.5113C>A	c.(5113-5115)Cgt>Agt	p.R1705S	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R1483S|XIRP2_ENST00000295237.9_Missense_Mutation_p.R1705S|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1530					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CACAATTGAGCGTGAAGAAGT	0.333000													17	59					4.7546e-09	6.01994e-09	1	1	0
B4GALNT2	124872	broad.mit.edu	37	17	47246047	47246047	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr17:47246047G>A	ENST00000300404.2	+	10	1339	c.1280G>A	c.(1279-1281)gGc>gAc	p.G427D	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.G367D|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.G341D	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	427					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GGCTAGGTAGGCGGCAGTGTG	0.502000													3	17					0	0	1	0	0
PFKFB1	5207	broad.mit.edu	37	X	54978500	54978500	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:54978500C>G	ENST00000375006.3	-	8	754	c.684G>C	c.(682-684)atG>atC	p.M228I	PFKFB1_ENST00000545676.1_Missense_Mutation_p.M163I|PFKFB1_ENST00000374992.2_Intron	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	228	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						CTCGGTTCACCATGTAGCGTG	0.562000													6	31					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40886673	40886673	+	Missense_Mutation	SNP	C	C	T	rs140678043		TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:40886673C>T	ENST00000291823.2	-	3	1509	c.1225G>A	c.(1225-1227)Ggc>Agc	p.G409S		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	409						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGGCTGCTGCCGGCCACACTG	0.647000													42	86					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724681	138724681	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:138724681C>A	ENST00000383163.2	-	1	429	c.430G>T	c.(430-432)Gca>Tca	p.A144S	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	144										endometrium(3)|kidney(1)|lung(7)	11						GGGACAGATGCGCAGAAGACT	0.652000													6	19					0.00198382	0.00209033	1	1	0
MAGEA5	4104	broad.mit.edu	37	X	151283471	151283471	+	RNA	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:151283471C>A	ENST00000509345.2	-	0	865																											GAGTCCCAGGCAGGTGACAAG	0.542000													12	91					5.50884e-06	6.35947e-06	1	1	0
OR9G1	390174	broad.mit.edu	37	11	56468240	56468240	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:56468240C>T	ENST00000312153.1	+	1	377	c.377C>T	c.(376-378)tCc>tTc	p.S126F		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						GTGGCCATCTCCAAGCCCCTG	0.522000													13	129					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54163498	54163498	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:54163498C>G	ENST00000265572.3	-	2	397	c.100G>C	c.(100-102)Gcc>Ccc	p.A34P	OPRK1_ENST00000520287.1_Missense_Mutation_p.A34P	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	34					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TCGGGCTCGGCCCAGCCGGGA	0.726000													9	21					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214560259	214560259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:214560259G>A	ENST00000366956.5	-	12	1188	c.994C>T	c.(994-996)Cag>Tag	p.Q332*	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	332					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TACGGCTGCTGCCTGGGCTGA	0.627000													4	23					0	0	1	0	0
CCDC71	64925	broad.mit.edu	37	3	49200405	49200405	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:49200405T>G	ENST00000321895.6	-	2	1343	c.1237A>C	c.(1237-1239)Aag>Cag	p.K413Q		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	413										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGCCATGCCTTAGGAGATCGG	0.572000													8	86					0	0	1	0	0
FHOD3	80206	broad.mit.edu	37	18	34273358	34273358	+	Silent	SNP	C	C	A	rs150630527	byFrequency	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr18:34273358C>A	ENST00000257209.4	+	14	1805	c.1683C>A	c.(1681-1683)tcC>tcA	p.S561S	FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000590592.1_Silent_p.S736S|FHOD3_ENST00000359247.4_Silent_p.S544S|FHOD3_ENST00000587493.1_3'UTR|FHOD3_ENST00000445677.1_Silent_p.S523S	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	544					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TGTCTGCCTCCTCCCCAGGAA	0.582000													4	22					0.184627	0.18701	1	1	0
DDX59	83479	broad.mit.edu	37	1	200635197	200635197	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:200635197C>A	ENST00000447706.2	-	2	823	c.672G>T	c.(670-672)gaG>gaT	p.E224D	DDX59_ENST00000331314.6_Missense_Mutation_p.E224D|DDX59_ENST00000367348.3_Missense_Mutation_p.E224D			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	224						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						GAGTTGGCACCTCATAGCCTG	0.448000													19	188					8.10497e-08	9.86419e-08	1	1	0
PLEKHH1	57475	broad.mit.edu	37	14	68050718	68050718	+	Silent	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr14:68050718G>T	ENST00000329153.5	+	26	3708	c.3576G>T	c.(3574-3576)ctG>ctT	p.L1192L	PLEKHH1_ENST00000417684.2_Silent_p.L57L	NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	1192	FERM.					cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCAGGCACCTGGCAGATATGT	0.537000											OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	37					0.0293803	0.0301485	1	1	0
NOX5	79400	broad.mit.edu	37	15	69347710	69347710	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr15:69347710C>A	ENST00000260364.5	+	16	2283	c.1982C>A	c.(1981-1983)gCa>gAa	p.A661E	NOX5_ENST00000448182.3_Missense_Mutation_p.A633E|NOX5_ENST00000455873.3_Missense_Mutation_p.A644E|NOX5_ENST00000530406.2_Missense_Mutation_p.A651E|NOX5_ENST00000388866.3_Missense_Mutation_p.A679E			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	679					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						ATGACATCTGCACTGGGCAAG	0.587000													11	38					6.40141e-05	7.17873e-05	1	1	0
WWC3	55841	broad.mit.edu	37	X	10047839	10047839	+	Silent	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:10047839G>C	ENST00000380861.4	+	5	763	c.372G>C	c.(370-372)ctG>ctC	p.L124L	WWC3_ENST00000454666.1_Silent_p.L124L	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	124										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						TGGAGACCCTGCAAGAGTGAG	0.428000													3	25					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436491	56436491	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:56436491G>A	ENST00000327381.5	+	3	1758	c.1658G>A	c.(1657-1659)cGc>cAc	p.R553H		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	553						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TCCAACAACCGCAGTGTTGTC	0.592000													20	49					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54967417	54967417	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:54967417C>T	ENST00000326764.5	+	9	1776	c.1297C>T	c.(1297-1299)Cgc>Tgc	p.R433C	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	396							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GCGCCACTTCCGCAGAAGGTA	0.622000													52	125					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40044124	40044124	+	Silent	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr12:40044124A>G	ENST00000324616.5	+	7	808	c.654A>G	c.(652-654)acA>acG	p.T218T	C12orf40_ENST00000405531.3_Silent_p.T218T|C12orf40_ENST00000398716.1_Silent_p.T141T	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	218										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATAAAACTACACGATTTGGGA	0.313000													7	30					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58349386	58349386	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:58349386A>G	ENST00000371015.1	+	7	1482	c.1015A>G	c.(1015-1017)Agg>Ggg	p.R339G	PHACTR3_ENST00000541461.1_Missense_Mutation_p.R298G|PHACTR3_ENST00000395636.2_Missense_Mutation_p.R298G|PHACTR3_ENST00000395639.4_Missense_Mutation_p.R228G|PHACTR3_ENST00000361300.4_Missense_Mutation_p.R228G|PHACTR3_ENST00000359926.3_Missense_Mutation_p.R336G|PHACTR3_ENST00000355648.4_Missense_Mutation_p.R298G	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	339						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GGGCAAGGAGAGGGAGGAGGC	0.507000													7	69					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	881567	881567	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:881567G>C	ENST00000312090.6	-	7	1283	c.1133C>G	c.(1132-1134)cCt>cGt	p.P378R	MED16_ENST00000606828.1_Intron|MED16_ENST00000325464.1_Missense_Mutation_p.P378R|MED16_ENST00000395808.3_Missense_Mutation_p.P378R|MED16_ENST00000269814.4_Missense_Mutation_p.P378R|MED16_ENST00000589119.1_Missense_Mutation_p.P378R			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	378					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGAGGCCAGGGTAGAACTG	0.672000													8	21					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1219413	1219413	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:1219413G>T	ENST00000326873.7	+	3	1637		c.e3+1			NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11						anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGCCCACGGGTGCGTGCGCG	0.657000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			2	2					0.004672	0.00482568	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85450464	85450464	+	Silent	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr12:85450464A>G	ENST00000393217.2	+	8	1954	c.1893A>G	c.(1891-1893)caA>caG	p.Q631Q		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	631										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TAATATTACAAGAAAAAGAAA	0.294000													4	30					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433384	73433384	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:73433384G>C	ENST00000263666.4	-	10	2447	c.2333C>G	c.(2332-2334)tCc>tGc	p.S778C	PDZRN3_ENST00000479530.1_Missense_Mutation_p.S495C|PDZRN3_ENST00000462146.2_Missense_Mutation_p.S435C|PDZRN3_ENST00000535920.1_Missense_Mutation_p.S500C|PDZRN3_ENST00000466780.1_Missense_Mutation_p.S435C	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	778							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCTCCTCAAGGAGTTGTCGGG	0.652000													7	36					0	0	1	0	0
ETFDH	2110	broad.mit.edu	37	4	159627456	159627456	+	Silent	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr4:159627456G>C	ENST00000511912.1	+	11	1733	c.1401G>C	c.(1399-1401)ggG>ggC	p.G467G	ETFDH_ENST00000307738.5_Silent_p.G420G	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	467					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		TATATGGAGGGATGATTTACA	0.393000													12	73					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148040	34148040	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:34148040C>A	ENST00000346193.3	-	1	2407	c.2356G>T	c.(2356-2358)Gag>Tag	p.E786*		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	786										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TCCGATGCCTCTACGATTTCT	0.378000													31	96					8.88839e-20	1.26862e-19	1	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55065393	55065393	+	RNA	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:55065393G>T	ENST00000526016.1	-	0	315					NR_038174.2																						GTGCTCCTGAGAGTTGGAATA	0.478000													6	34					2.74318e-10	3.64982e-10	1	1	0
BRCA2	675	broad.mit.edu	37	13	32910990	32910990	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr13:32910990T>G	ENST00000544455.1	+	11	2725	c.2498T>G	c.(2497-2499)cTg>cGg	p.L833R	BRCA2_ENST00000380152.3_Missense_Mutation_p.L833R	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	833	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AACGTTGAGCTGTTGCCACCT	0.308000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			15	54					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862811	10862811	+	RNA	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr21:10862811C>A	ENST00000559480.1	+	0	107																		p.S36L(1)		breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						CCTGGGGCCTCAGTGAAGGTC	0.562000													16	259					6.31663e-08	7.74774e-08	1	1	0
PHACTR3	116154	broad.mit.edu	37	20	58349490	58349490	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:58349490A>C	ENST00000371015.1	+	7	1586	c.1119A>C	c.(1117-1119)aaA>aaC	p.K373N	PHACTR3_ENST00000541461.1_Missense_Mutation_p.K332N|PHACTR3_ENST00000395636.2_Missense_Mutation_p.K332N|PHACTR3_ENST00000395639.4_Missense_Mutation_p.K262N|PHACTR3_ENST00000361300.4_Missense_Mutation_p.K262N|PHACTR3_ENST00000359926.3_Missense_Mutation_p.K370N|PHACTR3_ENST00000355648.4_Missense_Mutation_p.K332N	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	373						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTGAACTCAAAGACGACTTGC	0.502000													20	85					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616914	116616914	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:116616914C>A	ENST00000395715.3	-	4	1859	c.1282G>T	c.(1282-1284)Gtg>Ttg	p.V428L	TRPS1_ENST00000519076.1_Missense_Mutation_p.V369L|TRPS1_ENST00000220888.5_Missense_Mutation_p.V415L|TRPS1_ENST00000520276.1_Missense_Mutation_p.V419L|TRPS1_ENST00000519674.1_Missense_Mutation_p.V415L	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	415					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTATGGGCACTGAGTACCCA	0.468000									Langer-Giedion syndrome				9	40					1.76689e-08	2.18427e-08	1	1	0
VSX1	30813	broad.mit.edu	37	20	25059442	25059442	+	Missense_Mutation	SNP	C	C	T	rs6138482	by1000genomes	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:25059442C>T	ENST00000376707.3	-	3	684	c.650G>A	c.(649-651)cGc>cAc	p.R217H	VSX1_ENST00000451258.1_Intron|VSX1_ENST00000376709.4_Intron|VSX1_ENST00000429762.3_Intron|VSX1_ENST00000444511.2_Intron|VSX1_ENST00000424574.1_Intron	NM_199425.2	NP_955457.1	Q9NZR4	VSX1_HUMAN	visual system homeobox 1	0					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)	6						ATCTTTGGAGCGGAGAAAAGG	0.527000													7	165					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37734704	37734704	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:37734704A>G	ENST00000330843.4	-	2	749	c.737T>C	c.(736-738)gTg>gCg	p.V246A	RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.V98A|RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.V98A|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.V246A	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	246					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ACGAAGCAGCACTTTTTCTGG	0.493000													42	87					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479533	4479533	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr12:4479533G>C	ENST00000237837.1	-	3	877	c.732C>G	c.(730-732)tgC>tgG	p.C244W		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	244					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CGAAGGGGCGGCAGCCTTCCG	0.642000													16	78					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33988990	33988990	+	Silent	SNP	G	G	C	rs140158168	by1000genomes	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr9:33988990G>C	ENST00000379238.1	-	5	540	c.423C>G	c.(421-423)ggC>ggG	p.G141G	UBAP2_ENST00000379239.4_5'UTR|UBAP2_ENST00000449054.1_Silent_p.G141G|UBAP2_ENST00000360802.1_Silent_p.G141G|UBAP2_ENST00000539807.1_Intron|UBAP2_ENST00000418786.2_Silent_p.G141G			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	141								p.G141G(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		CACGATTGCCGCCTCTTCCTT	0.438000													27	153					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228092	21228092	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:21228092A>T	ENST00000233242.1	-	26	11775	c.11648T>A	c.(11647-11649)cTg>cAg	p.L3883Q		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3883					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCGTGCAGTCAGTGCTTGAAA	0.458000													21	88					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58349302	58349302	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:58349302C>T	ENST00000371015.1	+	7	1398	c.931C>T	c.(931-933)Caa>Taa	p.Q311*	PHACTR3_ENST00000541461.1_Nonsense_Mutation_p.Q270*|PHACTR3_ENST00000395636.2_Nonsense_Mutation_p.Q270*|PHACTR3_ENST00000395639.4_Nonsense_Mutation_p.Q200*|PHACTR3_ENST00000361300.4_Nonsense_Mutation_p.Q200*|PHACTR3_ENST00000359926.3_Nonsense_Mutation_p.Q308*|PHACTR3_ENST00000355648.4_Nonsense_Mutation_p.Q270*	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	311						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GTTTAGTTTTCAAGGAAGAGA	0.507000													6	46					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62964219	62964219	+	RNA	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr17:62964219T>A	ENST00000430983.1	-	0	1873					NR_026903.1																						TGAAAGAAGGTTCTAGTCTGT	0.343000													3	10					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37210704	37210704	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:37210704A>T	ENST00000585696.1	+	3	2215	c.985A>T	c.(985-987)Acg>Tcg	p.T329S	ZNF567_ENST00000588311.1_Missense_Mutation_p.T329S|ZNF567_ENST00000392163.2_Missense_Mutation_p.T329S|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000360729.4_Missense_Mutation_p.T329S|ZNF567_ENST00000536254.2_Missense_Mutation_p.T360S			Q8N184	ZN567_HUMAN	zinc finger protein 567	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAGAACTCACACGGGAGAGAA	0.453000													22	60					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105189873	105189873	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:105189873G>T	ENST00000428173.2	+	25	4375	c.4072G>T	c.(4072-4074)Gat>Tat	p.D1358Y	NRK_ENST00000243300.9_Missense_Mutation_p.D1357Y			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1357	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						AGTATGCATTGATCAATCAGC	0.423000										HNSCC(51;0.14)			18	47					6.94344e-10	9.00926e-10	1	1	0
IDO1	3620	broad.mit.edu	37	8	39775455	39775455	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:39775455T>A	ENST00000518237.1	+	2	788	c.149T>A	c.(148-150)aTa>aAa	p.I50K	IDO1_ENST00000522495.1_Missense_Mutation_p.I50K|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	50					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	CCTGATCTCATAGAGTCTGGC	0.328000													25	40					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14390383	14390383	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:14390383G>T	ENST00000344204.4	+	26	4126	c.4102G>T	c.(4102-4104)Gat>Tat	p.D1368Y	TRIO_ENST00000509967.2_Missense_Mutation_p.D1319Y|TRIO_ENST00000537187.1_Missense_Mutation_p.D1368Y	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1368	DH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GTTGCCAGAGGATGTTGGACA	0.368000													54	68					5.99346e-17	8.47723e-17	1	1	0
AGPAT4	56895	broad.mit.edu	37	6	161575165	161575165	+	Missense_Mutation	SNP	T	T	G	rs2277092	by1000genomes	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:161575165T>G	ENST00000366906.5	-	3	460	c.340A>C	c.(340-342)Agc>Cgc	p.S114R	AGPAT4_ENST00000457520.2_Intron|AGPAT4_ENST00000366908.5_3'UTR|AGPAT4_ENST00000366911.5_Intron|AGPAT4_ENST00000320285.4_Intron			Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	0					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		ACACAGCTGCTCTGGTGCCTA	0.592000													5	38					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14569168	14569168	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:14569168A>T	ENST00000242783.6	+	9	1565	c.1400A>T	c.(1399-1401)cAg>cTg	p.Q467L	PKN1_ENST00000342216.4_Missense_Mutation_p.Q473L	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	467					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						ATGGAACCCCAGGGCTGCCTG	0.552000													12	30					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71318455	71318455	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr16:71318455C>T	ENST00000338099.5	-	3	1705	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N	FTSJD1_ENST00000434935.2_Missense_Mutation_p.D457N			Q8IYT2	FTSJ1_HUMAN		457						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCTACTTTATCTTTCCATGAA	0.353000													12	71					0	0	1	0	0
SKAP1	8631	broad.mit.edu	37	17	46423351	46423351	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr17:46423351C>G	ENST00000336915.6	-	4	265	c.196G>C	c.(196-198)Gac>Cac	p.D66H	SKAP1_ENST00000584924.1_Missense_Mutation_p.D66H	NM_001075099.1|NM_003726.3	NP_001068567.1|NP_003717.3	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1	66					positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding			large_intestine(1)|lung(10)|prostate(2)|skin(4)|urinary_tract(1)	18						TCAGAGCTGTCCTGTCCAATG	0.433000													7	18					0	0	1	0	0
MRPS18B	28973	broad.mit.edu	37	6	30587514	30587514	+	Silent	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:30587514C>T	ENST00000259873.4	+	3	373	c.216C>T	c.(214-216)ccC>ccT	p.P72P	MRPS18B_ENST00000506373.2_Silent_p.P72P|MRPS18B_ENST00000472229.1_3'UTR	NM_014046.3	NP_054765.1	Q9Y676	RT18B_HUMAN	mitochondrial ribosomal protein S18B	72					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(2)	13						GTTCTCGCCCCGTCTGGGCTG	0.522000													13	57					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46190910	46190910	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:46190910G>T	ENST00000371374.1	-	5	891	c.700C>A	c.(700-702)Cgt>Agt	p.R234S	RCAN2_ENST00000306764.7_Missense_Mutation_p.R234S|RCAN2_ENST00000330430.6_Missense_Mutation_p.R188S|RCAN2_ENST00000405162.1_Missense_Mutation_p.R234S	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	188					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AGGCCAGGACGCCGAGTTTGG	0.527000													13	82					2.32078e-09	2.9623e-09	1	1	0
CLMN	79789	broad.mit.edu	37	14	95688087	95688087	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr14:95688087G>C	ENST00000298912.4	-	4	378	c.265C>G	c.(265-267)Cat>Gat	p.H89D		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	89	Actin-binding.|CH 1.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		AAAATACGATGCGACGAGGAT	0.443000													5	48					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2021432	2021432	+	Silent	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr8:2021432A>G	ENST00000262113.4	+	10	1113	c.972A>G	c.(970-972)aaA>aaG	p.K324K	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	324	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGCTGTTGAAAGAGTCCAAGT	0.562000													21	68					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46658186	46658186	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:46658186T>C	ENST00000544460.1	+	1	2575	c.2321T>C	c.(2320-2322)gTa>gCa	p.V774A	TDRD6_ENST00000316081.6_Missense_Mutation_p.V774A	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	774					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GGAAGTACAGTAGAAGTCAGA	0.398000													8	42					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009352	120009352	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:120009352A>C	ENST00000371311.3	-	1	427	c.173T>G	c.(172-174)gTg>gGg	p.V58G		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	58										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GAGGCCTTCCACGGGCCCTGC	0.751000													13	52					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788740	140788740	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:140788740G>A	ENST00000520790.1	+	1	971	c.971G>A	c.(970-972)gGa>gAa	p.G324E	PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAAGGACGGAGGTGGTCTC	0.388000													42	68					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110784900	110784900	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:110784900C>A	ENST00000282356.4	+	7	1022	c.625_splice	c.e7+1	p.C208_splice	CAMK4_ENST00000512453.1_Splice_Site_p.C208_splice	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	208	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity	p.C208C(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		CAGGGTACTGCGGTATGCTCT	0.274000													6	45					1	1	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141115668	141115668	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:141115668C>A	ENST00000389484.3	-	74	12246	c.11275G>T	c.(11275-11277)Gca>Tca	p.A3759S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3759					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAAGGCCTTGCTTTATATGTC	0.363000										TSP Lung(27;0.18)			21	73					1.9806e-07	2.37369e-07	1	1	0
ZNF180	7733	broad.mit.edu	37	19	44981877	44981877	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:44981877C>A	ENST00000221327.4	-	5	1102	c.821G>T	c.(820-822)gGa>gTa	p.G274V	ZNF180_ENST00000592529.1_Missense_Mutation_p.G247V|ZNF180_ENST00000391956.4_Missense_Mutation_p.G249V	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				GTCACTAAATCCATAGCATTT	0.348000													17	110					3.52763e-06	4.13312e-06	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	47847175	47847175	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:47847175T>A	ENST00000339488.4	-	3	1438	c.1405A>T	c.(1405-1407)Atc>Ttc	p.I469F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	469						integral to membrane	hedgehog receptor activity										AGATAGAGGATGACAACAAAT	0.438000													3	34					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806408	54806408	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:54806408G>T	ENST00000306858.7	+	5	2755	c.2639G>T	c.(2638-2640)aGg>aTg	p.R880M		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	880										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTCTTGGAAAGGGCAGGAGAT	0.433000													13	61					1.5842e-08	1.97396e-08	1	1	0
FMN2	56776	broad.mit.edu	37	1	240370204	240370204	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:240370204C>T	ENST00000319653.9	+	5	2322	c.2092C>T	c.(2092-2094)Cct>Tct	p.P698S		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	698					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGGCAGTATCCTGCCCTGGA	0.498000													12	65					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37396632	37396632	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:37396632A>G	ENST00000361924.2	+	22	6991	c.6617A>G	c.(6616-6618)gAt>gGt	p.D2206G	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.D2221G	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	2206	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AAGTTCCCTGATGATCAGACT	0.393000													12	73					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84256090	84256090	+	Silent	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr16:84256090G>A	ENST00000308251.4	-	3	1361	c.1293C>T	c.(1291-1293)ggC>ggT	p.G431G		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	431						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						CCACCATCTGGCCTGGCACAC	0.622000													20	45					0	0	1	0	0
CHMP1B	57132	broad.mit.edu	37	18	11852092	11852092	+	Silent	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr18:11852092C>T	ENST00000526991.2	+	1	698	c.582C>T	c.(580-582)cgC>cgT	p.R194R	RP11-78A19.3_ENST00000586474.1_RNA|GNAL_ENST00000535121.1_Intron|GNAL_ENST00000423027.3_Intron|GNAL_ENST00000269162.5_Intron|GNAL_ENST00000334049.6_Intron	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	194	Interaction with SPAST.|Interaction with VPS4A, MITD1 and STAMBP.|Interaction with VPS4B.|Interaction with VTA1.				cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GACTGGCCCGCCTTCGGGATC	0.597000													4	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179572463	179572463	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:179572463A>T	ENST00000589042.1	-	100	29055	c.28831T>A	c.(28831-28833)Tgc>Agc	p.C9611S	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.C8367S|TTN_ENST00000591111.1_Missense_Mutation_p.C9294S|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9294							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGACATGGCAGCTGAGCTGC	0.473000													20	84					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141130687	141130687	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:141130687C>A	ENST00000389484.3	-	69	11629	c.10658G>T	c.(10657-10659)tGt>tTt	p.C3553F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3553	LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCTTTGGAACAACTTGTCTC	0.348000										TSP Lung(27;0.18)			10	57					0.000442599	0.000479228	1	1	0
TNFAIP3	7128	broad.mit.edu	37	6	138196953	138196953	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr6:138196953G>T	ENST00000237289.4	+	4	681	c.615G>T	c.(613-615)agG>agT	p.R205S		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	205	OTU.|TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TCCTCAGAAGGCCAATCATTG	0.463000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								22	103					3.5997e-14	4.91437e-14	1	1	0
B2M	567	broad.mit.edu	37	15	45007690	45007690	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr15:45007690A>G	ENST00000558401.1	+	2	207	c.137A>G	c.(136-138)tAt>tGt	p.Y46C	B2M_ENST00000544417.1_Missense_Mutation_p.Y46C|B2M_ENST00000559916.1_Missense_Mutation_p.Y46C|B2M_ENST00000559220.1_Intron	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	46	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		CTGAATTGCTATGTGTCTGGG	0.403000													33	105					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126142390	126142390	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:126142390C>A	ENST00000393425.1	+	13	1291	c.1192C>A	c.(1192-1194)Ctg>Atg	p.L398M	CCDC37_ENST00000505024.1_Missense_Mutation_p.L398M|CCDC37_ENST00000352312.1_Missense_Mutation_p.L397M			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	397										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CTTCCGAGAGCTGGAGGAGCA	0.592000													6	41					5.9392e-07	7.06405e-07	1	1	0
RAG1	5896	broad.mit.edu	37	11	36595703	36595703	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:36595703C>A	ENST00000299440.5	+	2	961	c.849C>A	c.(847-849)ttC>ttA	p.F283L		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	283	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				CAGTGGACTTCCCAGAGCACT	0.493000									Familial Hemophagocytic Lymphohistiocytosis				14	71					0.000308642	0.000338859	1	1	0
GAPVD1	26130	broad.mit.edu	37	9	128118030	128118030	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr9:128118030G>T	ENST00000470056.1	+	22	3944	c.3784G>T	c.(3784-3786)Gaa>Taa	p.E1262*	GAPVD1_ENST00000265956.4_Nonsense_Mutation_p.E1281*|GAPVD1_ENST00000312123.9_Nonsense_Mutation_p.E1268*|GAPVD1_ENST00000394083.2_Nonsense_Mutation_p.E1241*|GAPVD1_ENST00000495955.1_Nonsense_Mutation_p.E1307*|GAPVD1_ENST00000394104.2_Nonsense_Mutation_p.E1307*|GAPVD1_ENST00000394105.2_Nonsense_Mutation_p.E1316*|GAPVD1_ENST00000297933.6_Nonsense_Mutation_p.E1289*			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1307					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AAACGCGAGTGAAGAACAGCT	0.478000													13	44					5.50884e-06	6.35947e-06	1	1	0
ZNF532	55205	broad.mit.edu	37	18	56586594	56586594	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr18:56586594C>T	ENST00000336078.4	+	4	1851	c.1075C>T	c.(1075-1077)Ccc>Tcc	p.P359S	ZNF532_ENST00000591808.1_Missense_Mutation_p.P359S|ZNF532_ENST00000591083.1_Missense_Mutation_p.P359S|ZNF532_ENST00000589288.1_Missense_Mutation_p.P359S|ZNF532_ENST00000591230.1_Missense_Mutation_p.P359S	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						ACCAGCAATCCCCAAAGTCCG	0.498000													10	54					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2333341	2333341	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr16:2333341T>G	ENST00000301732.5	-	26	4581	c.3881A>C	c.(3880-3882)aAc>aCc	p.N1294T	ABCA3_ENST00000382381.3_Missense_Mutation_p.N1236T	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1294					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GGCATAGAAGTTCTCCTGGTA	0.677000													8	29					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452702	179452702	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:179452702C>A	ENST00000589042.1	-	305	63656	c.63432G>T	c.(63430-63432)agG>agT	p.R21144S	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12204S|TTN_ENST00000342175.6_Missense_Mutation_p.R12271S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R18576S|TTN_ENST00000591111.1_Missense_Mutation_p.R19503S|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12079S|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19503	Fibronectin type-III 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCACACACCCTGAACTCAT	0.468000													7	25					0.00307968	0.00320205	1	1	0
LRIF1	55791	broad.mit.edu	37	1	111494366	111494366	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:111494366G>C	ENST00000369763.4	-	2	1530	c.1140C>G	c.(1138-1140)gaC>gaG	p.D380E	LRIF1_ENST00000494675.1_Intron|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000485275.2_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						AATTCTGTTGGTCAATTTGTG	0.373000													39	149					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180243354	180243354	+	Silent	SNP	T	T	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:180243354T>C	ENST00000263726.2	+	6	1057	c.813T>C	c.(811-813)aaT>aaC	p.N271N	RP5-1180C10.2_ENST00000440959.2_RNA|RP5-1180C10.2_ENST00000415414.1_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	271						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						GCCACACCAATAGGATTTATG	0.498000													43	98					0	0	1	0	0
CCDC71	64925	broad.mit.edu	37	3	49200970	49200970	+	Silent	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:49200970C>A	ENST00000321895.6	-	2	778	c.672G>T	c.(670-672)cgG>cgT	p.R224R		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	224										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GAGCTTTGGGCCGAGGGTTCC	0.597000													17	68					6.94344e-10	9.00926e-10	1	1	0
SLC4A11	83959	broad.mit.edu	37	20	3210840	3210840	+	Silent	SNP	C	C	A	rs139907702		TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:3210840C>A	ENST00000380059.3	-	13	1712	c.1611G>T	c.(1609-1611)acG>acT	p.T537T	SLC4A11_ENST00000539553.1_Silent_p.T494T|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Silent_p.T510T	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	510	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						CACTTTTAACCGTGCCCTTGA	0.612000													9	43					3.86212e-05	4.39386e-05	1	1	0
SFXN4	119559	broad.mit.edu	37	10	120917526	120917526	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr10:120917526G>A	ENST00000355697.2	-	7	428	c.409C>T	c.(409-411)Cct>Tct	p.P137S	SFXN4_ENST00000461438.1_5'UTR|SFXN4_ENST00000330036.6_Missense_Mutation_p.P128S	NM_213649.1	NP_998814.1	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	137					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	11		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		GCTACCTGAGGTAAAATCACG	0.433000													23	77					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123598272	123598272	+	Silent	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:123598272G>A	ENST00000336139.4	-	7	1226	c.864C>T	c.(862-864)tcC>tcT	p.S288S	ZNF202_ENST00000529691.1_Silent_p.S288S|ZNF202_ENST00000530393.1_Silent_p.S288S			O95125	ZN202_HUMAN	zinc finger protein 202	288	KRAB.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CTCTAACCTGGGAGATCTCAT	0.483000													15	48					0	0	1	0	0
MBNL3	55796	broad.mit.edu	37	X	131540291	131540291	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:131540291G>T	ENST00000538204.1	-	2	222	c.157C>A	c.(157-159)Cag>Aag	p.Q53K	RP5-842K24.2_ENST00000421483.1_RNA|MBNL3_ENST00000370839.3_Missense_Mutation_p.Q103K|RP5-842K24.2_ENST00000441399.1_RNA|MBNL3_ENST00000473364.1_5'UTR|MBNL3_ENST00000370857.3_Missense_Mutation_p.Q103K|MBNL3_ENST00000370849.3_Missense_Mutation_p.Q53K|MBNL3_ENST00000394311.2_Missense_Mutation_p.Q7K|MBNL3_ENST00000370844.1_Missense_Mutation_p.Q7K|MBNL3_ENST00000370853.3_Missense_Mutation_p.Q103K	NM_001170702.1	NP_001164173.1	Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	103					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					AGCATAAGCTGCATCTGCTGG	0.468000													21	89					1.10513e-12	1.49574e-12	1	1	0
ZNF345	25850	broad.mit.edu	37	19	37367862	37367862	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:37367862G>T	ENST00000529555.1	+	2	918	c.130G>T	c.(130-132)Gac>Tac	p.D44Y	ZNF345_ENST00000589046.1_Missense_Mutation_p.D44Y|ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000420450.1_Missense_Mutation_p.D44Y|ZNF345_ENST00000526123.1_Intron			Q14585	ZN345_HUMAN	zinc finger protein 345	44					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TACTCCTGAAGACATGCCCAC	0.388000													47	112					5.57489e-27	8.17998e-27	1	1	0
DDX59	83479	broad.mit.edu	37	1	200635199	200635199	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:200635199C>A	ENST00000447706.2	-	2	821	c.670G>T	c.(670-672)Gag>Tag	p.E224*	DDX59_ENST00000331314.6_Nonsense_Mutation_p.E224*|DDX59_ENST00000367348.3_Nonsense_Mutation_p.E224*			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	224						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						GTTGGCACCTCATAGCCTGAT	0.443000													20	190					1.28384e-07	1.55048e-07	1	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704345	56704345	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:56704345A>C	ENST00000586855.2	-	2	390	c.77T>G	c.(76-78)gTg>gGg	p.V26G	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.V26G			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	26					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TGGGGACGCCACAGACCGTGG	0.527000													6	11					0	0	1	0	0
CENPI	2491	broad.mit.edu	37	X	100401267	100401267	+	Splice_Site	SNP	G	G	C			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:100401267G>C	ENST00000372927.1	+	17	2103		c.e17+1		CENPI_ENST00000218507.5_Splice_Site|CENPI_ENST00000423383.1_Splice_Site	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						TTATGCACAGGTACAAAGCCT	0.398000													24	94					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55718224	55718224	+	Missense_Mutation	SNP	T	T	C	rs148819962	byFrequency	TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:55718224T>C	ENST00000376350.3	-	3	207	c.185A>G	c.(184-186)aAc>aGc	p.N62S	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Missense_Mutation_p.N62S	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	62	Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AACCCAGTAGTTGGAGTTCTG	0.587000													32	78					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77244929	77244929	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chrX:77244929C>A	ENST00000341514.6	+	4	966	c.811C>A	c.(811-813)Cca>Aca	p.P271T	ATP7A_ENST00000343533.5_Missense_Mutation_p.P271T|ATP7A_ENST00000350425.4_Intron	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	271					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						GCAAAGGAGTCCATCATATAC	0.388000													32	165					2.08457e-15	2.92212e-15	1	1	0
EPHA10	284656	broad.mit.edu	37	1	38227288	38227288	+	Silent	SNP	G	G	A			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr1:38227288G>A	ENST00000373048.4	-	3	638	c.639C>T	c.(637-639)gcC>gcT	p.A213A	EPHA10_ENST00000427468.2_Silent_p.A213A|EPHA10_ENST00000319637.6_Silent_p.A213A	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	213						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCGCACGGTGGCGCGGCACT	0.697000													7	24					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48052582	48052582	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr15:48052582A>G	ENST00000316364.5	+	3	630	c.191A>G	c.(190-192)aAa>aGa	p.K64R	SEMA6D_ENST00000389428.3_Missense_Mutation_p.K64R|SEMA6D_ENST00000355997.3_Missense_Mutation_p.K64R|SEMA6D_ENST00000537942.1_Missense_Mutation_p.K64R|SEMA6D_ENST00000558816.1_Missense_Mutation_p.K64R|SEMA6D_ENST00000558014.1_Missense_Mutation_p.K64R|SEMA6D_ENST00000536845.2_Missense_Mutation_p.K64R|SEMA6D_ENST00000358066.4_Missense_Mutation_p.K64R|SEMA6D_ENST00000389425.3_Missense_Mutation_p.K64R|SEMA6D_ENST00000389432.2_Missense_Mutation_p.K64R|SEMA6D_ENST00000354744.4_Missense_Mutation_p.K64R|SEMA6D_ENST00000389433.2_Missense_Mutation_p.K64R	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	64	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CTGATGTTGAAAATTCGAGAC	0.403000													8	45					0	0	1	0	0
FAM84A	151354	broad.mit.edu	37	2	14774226	14774226	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:14774226delG	ENST00000295092.2	+	2	411	c.123delG	c.(121-123)gafs	p.E42fs	FAM84A_ENST00000331243.4_Frame_Shift_Del_p.E42fs	NM_145175.2	NP_660158.2	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	42										endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			CGGATGATGAGGAAGACCTGG	0.652													8	29	---	---	---	---					
IGKV1-27	28935	broad.mit.edu	37	2	89512961	89512961	+	RNA	DEL	G	G	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr2:89512961delG	ENST00000498435.1	-	0	328																											TCAGGCTGCAGGCTGCTGATG	0.488													11	80	---	---	---	---					
PBX2P1	5088	broad.mit.edu	37	3	142895155	142895155	+	RNA	DEL	C	C	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr3:142895155delC	ENST00000560287.1	+	0	29																											GGCCTCAGGGCCCCCCCCCAG	0.746													3	6	---	---	---	---					
MTNR1A	4543	broad.mit.edu	37	4	187455142	187455142	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr4:187455142delC	ENST00000307161.5	-	2	955	c.754delG	c.(754-756)ctfs	p.A252fs	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	252					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TTCAGAGGAGCCCAGCAAATG	0.522													13	81	---	---	---	---					
AACSP1	729522	broad.mit.edu	37	5	178213643	178213643	+	RNA	DEL	T	T	-	rs111517974		TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr5:178213643delT	ENST00000503486.2	-	0	647					NR_024035.1																						CCGGTCTGCCTTCCAGAGGCG	0.597													5	1	---	---	---	---					
TRBV5-6	28609	broad.mit.edu	37	7	142131427	142131428	+	RNA	DEL	AG	AG	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr7:142131427_142131428delAG	ENST00000390375.2	-	0	367_368																											CTGCTGGCACAGAGATAGAGGG	0.530													17	84	---	---	---	---					
RTN4RL2	349667	broad.mit.edu	37	11	57243952	57243953	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr11:57243952_57243953delGC	ENST00000335099.3	+	3	1148_1149	c.831_832delGC	c.(829-834)cagcfs	p.QR277fs		NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	277	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCTGGTTCCAGCGCGCGCGCGT	0.762													2	4	---	---	---	---					
PIK3C3	5289	broad.mit.edu	37	18	39575886	39575887	+	Frame_Shift_Ins	INS	-	-	G			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr18:39575886_39575887insG	ENST00000262039.4	+	8	905_906	c.819_820insG	c.(817-822)ctcccgfs	p.LP273fs	PIK3C3_ENST00000398870.3_Frame_Shift_Ins_p.LP210fs	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	273				KLA -> NLP (in Ref. 1; CAA87094).	cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						ACCACAAGCTTGCCCGGAGTTT	0.332										TSP Lung(28;0.18)			20	62	---	---	---	---					
DPP9	91039	broad.mit.edu	37	19	4695508	4695508	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr19:4695508delG	ENST00000262960.9	-	12	1512	c.1235delC	c.(1234-1236)cgfs	p.P412fs	DPP9_ENST00000598800.1_Frame_Shift_Del_p.P383fs|DPP9_ENST00000597849.1_Frame_Shift_Del_p.P412fs|DPP9_ENST00000594671.1_Frame_Shift_Del_p.P383fs	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	383					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GAACAGGGCCGGGGGGAGGAG	0.647													2	4	---	---	---	---					
SCRT2	85508	broad.mit.edu	37	20	656129	656129	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4TH-01A-31D-A25L-08	TCGA-MP-A4TH-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	AA945427-6ACE-4C45-8E46-4FF11C6EF2B7	8E27DDE2-9F59-417A-B579-EB53BAA0ECC6	g.chr20:656129delC	ENST00000246104.6	-	1	694	c.117delG	c.(115-117)ggfs	p.G39fs	RP5-850E9.3_ENST00000488788.2_Frame_Shift_Del_p.G39fs	NM_033129.3	NP_149120.1	Q9NQ03	SCRT2_HUMAN	scratch family zinc finger 2	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|liver(1)|ovary(1)	3						CCCCGGGAGGCCCCCGGGCGC	0.716													2	4	---	---	---	---					
