Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAP3K19	80122	broad.mit.edu	37	2	135744717	135744717	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:135744717C>T	ENST00000375845.3	-	7	1755	c.1725G>A	c.(1723-1725)ccG>ccA	p.P575P	MAP3K19_ENST00000392915.1_Silent_p.P592P|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Silent_p.P462P|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392918.3_Intron	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GTCCCAAAGCCGGGAAAATTT	0.438000													46	118					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215990521	215990521	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:215990521A>G	ENST00000366943.2	-	48	9774	c.9388T>C	c.(9388-9390)Tgg>Cgg	p.W3130R	USH2A_ENST00000307340.3_Missense_Mutation_p.W3130R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3130	Fibronectin type-III 18.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAGACACCCAATCAATTTGA	0.378000										HNSCC(13;0.011)			39	95					0	0	1	0	0
PPP6R3	55291	broad.mit.edu	37	11	68358180	68358180	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:68358180A>G	ENST00000393799.2	+	17	2050	c.1783A>G	c.(1783-1785)Agt>Ggt	p.S595G	PPP6R3_ENST00000265636.5_Missense_Mutation_p.S515G|PPP6R3_ENST00000265637.4_Missense_Mutation_p.S549G|PPP6R3_ENST00000393800.2_Missense_Mutation_p.S595G|PPP6R3_ENST00000534534.1_Missense_Mutation_p.S363G|PPP6R3_ENST00000527403.2_Missense_Mutation_p.S560G|PPP6R3_ENST00000524904.1_Missense_Mutation_p.S589G|PPP6R3_ENST00000393801.3_Missense_Mutation_p.S595G|PPP6R3_ENST00000529710.1_Missense_Mutation_p.S515G|PPP6R3_ENST00000524845.1_Missense_Mutation_p.S566G			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	595					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TACAAATGAAAGTGTAAGTAT	0.388000													3	21					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371650	55371650	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:55371650G>A	ENST00000302231.4	-	1	224	c.200C>T	c.(199-201)gCa>gTa	p.A67V		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GCAAGAATCTGCAAAGGACAA	0.408000													46	83					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803783	142803783	+	RNA	SNP	A	A	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:142803783A>T	ENST00000423385.1	-	0	1182																											atagttaacaaagtagctggc	0.403000													2	2					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850195	98850195	+	RNA	SNP	C	C	T	rs829864	by1000genomes	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:98850195C>T	ENST00000554295.1	-	0	728					NR_033801.1																						TCTCATAATCCTCATGAGCTT	0.423000													4	53					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332776	22332776	+	RNA	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr15:22332776G>T	ENST00000558896.1	+	0	583																											GCCTATGACAGGTATGTTGCC	0.488000													37	97					2.47316e-13	2.68703e-13	1	1	0
PPTC7	160760	broad.mit.edu	37	12	110983717	110983717	+	Silent	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:110983717G>A	ENST00000354300.3	-	3	858	c.570C>T	c.(568-570)ccC>ccT	p.P190P		NM_139283.1	NP_644812.1	Q8NI37	PPTC7_HUMAN	PTC7 protein phosphatase homolog (S. cerevisiae)	190	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity			endometrium(1)|large_intestine(2)|lung(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	9						CGGCTTCAGGGGGAGCGATTG	0.562000													52	101					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70348241	70348241	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:70348241C>A	ENST00000333646.6	+	23	3504	c.3305C>A	c.(3304-3306)tCc>tAc	p.S1102Y	MED12_ENST00000374080.3_Missense_Mutation_p.S1102Y|MED12_ENST00000374102.1_Missense_Mutation_p.S1102Y	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1102					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TTGTGCTGCTCCTCTAACAAT	0.537000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						57	154					2.12129e-23	2.49563e-23	1	1	0
COL14A1	7373	broad.mit.edu	37	8	121290443	121290443	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr8:121290443A>G	ENST00000297848.3	+	27	3577	c.3307A>G	c.(3307-3309)Att>Gtt	p.I1103V	COL14A1_ENST00000309791.4_Missense_Mutation_p.I1103V|COL14A1_ENST00000247781.3_Missense_Mutation_p.I1008V	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1103	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATTAAACACATTTCATACAA	0.348000													48	49					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579617	55579617	+	Silent	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:55579617C>A	ENST00000333973.2	+	1	764	c.675C>A	c.(673-675)atC>atA	p.I225I		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TCACCACCATCCTGAAGATGG	0.502000													88	83					8.6486e-37	1.10408e-36	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52380539	52380539	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr3:52380539C>A	ENST00000420323.2	+	11	1969	c.1708C>A	c.(1708-1710)Cgc>Agc	p.R570S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	570	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGTGGCCATGCGCAGCAGCCT	0.587000													8	15					0.00307968	0.00313188	1	1	0
ARL8A	127829	broad.mit.edu	37	1	202103599	202103599	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:202103599C>T	ENST00000272217.2	-	7	725	c.557G>A	c.(556-558)aGc>aAc	p.S186N		NM_001256129.1|NM_138795.3	NP_001243058.1|NP_620150.1	Q96BM9	ARL8A_HUMAN	ADP-ribosylation factor-like 8A	186					cell division|chromosome segregation|mitosis|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GTP binding|GTPase activity			large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						GGAGTCTCAGCTTCTCCGTGA	0.567000													42	168					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166226649	166226649	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:166226649T>C	ENST00000357398.3	+	20	3979	c.3689T>C	c.(3688-3690)aTa>aCa	p.I1230T	SCN2A_ENST00000375427.2_Missense_Mutation_p.I1230T|SCN2A_ENST00000375437.2_Missense_Mutation_p.I1230T|SCN2A_ENST00000283256.6_Missense_Mutation_p.I1230T			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1230					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTTGAAGATATATACATTGAG	0.328000													40	47					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900126	202900126	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:202900126C>T	ENST00000286201.1	+	1	817	c.756C>T	c.(754-756)ttC>ttT	p.F252F		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	252					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						AGAGGCGCTTCGCCCGCCTCT	0.657000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	67					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29449860	29449860	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:29449860G>T	ENST00000389048.3	-	18	3901	c.2995C>A	c.(2995-2997)Cct>Act	p.P999T	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	999					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGGCTTTCAGGGTCCATGTGA	0.552000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				97	148					1.74666e-38	2.25375e-38	1	1	0
PPP1R3C	5507	broad.mit.edu	37	10	93390557	93390557	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr10:93390557C>A	ENST00000238994.5	-	2	165	c.81G>T	c.(79-81)agG>agT	p.R27S		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	27							protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				CCAAGCAAAGCCTCATGGCCA	0.458000													56	135					3.4597e-24	4.19358e-24	1	1	0
CDX4	1046	broad.mit.edu	37	X	72673397	72673397	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:72673397C>T	ENST00000373514.2	+	2	547	c.547C>T	c.(547-549)Cat>Tat	p.H183Y		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	183						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					TTACACTGATCATCAAAGATT	0.393000													15	34					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067483	190067483	+	Silent	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:190067483G>T	ENST00000367462.3	-	8	2197	c.1966C>A	c.(1966-1968)Cgg>Agg	p.R656R	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.R554R	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		656						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CCCAGGTTCCGGGAAGGGTCA	0.443000													85	301					7.427e-35	9.38147e-35	1	1	0
DNAJC21	134218	broad.mit.edu	37	5	34936260	34936260	+	Silent	SNP	G	G	A	rs147400420	byFrequency	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:34936260G>A	ENST00000382021.2	+	4	554	c.327G>A	c.(325-327)acG>acA	p.T109T	DNAJC21_ENST00000303525.7_Silent_p.T109T|DNAJC21_ENST00000342382.4_Silent_p.T109T	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	109					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding	p.T109T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			GATTTTACACGGTGTATCGTA	0.318000													34	77					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36747942	36747942	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr13:36747942T>C	ENST00000379881.3	-	9	975	c.887A>G	c.(886-888)aAc>aGc	p.N296S	SOHLH2_ENST00000554962.1_Missense_Mutation_p.N373S|CCDC169-SOHLH2_ENST00000511166.1_Missense_Mutation_p.N373S	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CATCACACTGTTTTCCCTTGA	0.428000													17	27					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146077624	146077624	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:146077624C>T	ENST00000394413.3	-	3	822	c.252G>A	c.(250-252)aaG>aaA	p.K84K	PPP2R2B_ENST00000394411.4_Silent_p.K84K|PPP2R2B_ENST00000394414.1_Silent_p.K150K|PPP2R2B_ENST00000504198.1_Silent_p.K90K|PPP2R2B_ENST00000508545.2_Silent_p.K73K|PPP2R2B_ENST00000453001.1_Silent_p.K84K|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394409.3_Silent_p.K142K|PPP2R2B_ENST00000356826.3_Silent_p.K84K|PPP2R2B_ENST00000336640.6_Silent_p.K87K|PPP2R2B_ENST00000394410.2_Silent_p.K73K			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	84					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCTAAACTCTTCAGGTAAT	0.388000													5	66					0	0	1	0	0
TPSB2	64499	broad.mit.edu	37	16	1278609	1278609	+	RNA	SNP	G	G	C	rs77309587	by1000genomes	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr16:1278609G>C	ENST00000430512.2	-	0	917				TPSB2_ENST00000339687.6_RNA|TPSB2_ENST00000445910.1_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				AACAGGAGGGGCTGGCTCTCC	0.612000													4	41					0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	869929	869929	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:869929G>A	ENST00000449825.1	-	13	1467	c.1111C>T	c.(1111-1113)Cgg>Tgg	p.R371W	CHID1_ENST00000323578.8_Missense_Mutation_p.R371W|CHID1_ENST00000528581.1_Missense_Mutation_p.R396W|CHID1_ENST00000436108.2_Missense_Mutation_p.R371W|CHID1_ENST00000454838.2_Missense_Mutation_p.R396W|CHID1_ENST00000429789.2_Missense_Mutation_p.R340W|CHID1_ENST00000336845.5_Missense_Mutation_p.R396W|CHID1_ENST00000323541.7_Missense_Mutation_p.R401W	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	371					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		CCCAGCTCCCGGGCCAGCTCC	0.677000													23	45					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78931486	78931486	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr17:78931486C>T	ENST00000306801.3	+	29	3795	c.3433C>T	c.(3433-3435)Cgg>Tgg	p.R1145W	RPTOR_ENST00000544334.2_Missense_Mutation_p.R987W|RPTOR_ENST00000575542.1_3'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	1145					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						AGGAGACGTGCGGATCGTCCG	0.627000													51	73					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477672	6477672	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:6477672C>T	ENST00000525074.1	-	6	1678	c.1284G>A	c.(1282-1284)ccG>ccA	p.P428P	TRIM3_ENST00000537602.1_Silent_p.P350P|TRIM3_ENST00000536344.1_Silent_p.P309P|TRIM3_ENST00000345851.3_Silent_p.P428P|TRIM3_ENST00000529058.1_Intron|TRIM3_ENST00000359518.3_Silent_p.P428P	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	428					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCACATCGTCCGGGGAAGGTG	0.697000													9	16					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68154038	68154038	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:68154038G>T	ENST00000294304.7	+	6	1376	c.1270G>T	c.(1270-1272)Gac>Tac	p.D424Y		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	424	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CATCGCGGTCGACTGGGTGGC	0.667000													30	39					9.39395e-14	1.0342e-13	1	1	0
IGHV1OR16-4	28312	broad.mit.edu	37	16	33013816	33013816	+	RNA	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr16:33013816G>T	ENST00000567619.1	-	0	499																											GGTGCAGTCTGGGGCTGAGGT	0.597000													22	54					3.93418e-24	4.72102e-24	1	1	0
TNR	7143	broad.mit.edu	37	1	175335202	175335202	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:175335202G>T	ENST00000367674.1	-	11	2834	c.2126C>A	c.(2125-2127)gCc>gAc	p.A709D	TNR_ENST00000263525.2_Missense_Mutation_p.A709D	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	709	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GGGGCCACTGGCCTTGGTCCA	0.522000													37	141					1.36161e-19	1.55613e-19	1	1	0
MAGEB3	4114	broad.mit.edu	37	X	30254629	30254629	+	Silent	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:30254629G>A	ENST00000361644.2	+	5	1325	c.588G>A	c.(586-588)agG>agA	p.R196R	MAGEB3_ENST00000378986.1_Silent_p.R196R	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	196	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CTCGTGGGAGGGGATTTCCCA	0.468000													6	74					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	133996938	133996938	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:133996938A>G	ENST00000398844.2	+	2	515	c.227A>G	c.(226-228)tAt>tGt	p.Y76C	SEC24A_ENST00000322887.4_Missense_Mutation_p.Y76C	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	76					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGTCTAACTATGGTGGTTCT	0.498000													156	55					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081594	143081594	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr6:143081594G>A	ENST00000367603.2	-	9	6573	c.5831C>T	c.(5830-5832)tCc>tTc	p.S1944F	HIVEP2_ENST00000367604.1_Missense_Mutation_p.S1944F|HIVEP2_ENST00000012134.2_Missense_Mutation_p.S1944F	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1944					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGGCAAGGAGGAGAATCTAGG	0.463000													38	22					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055724	75055724	+	Silent	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:75055724A>G	ENST00000326665.5	-	12	1985	c.1767T>C	c.(1765-1767)ccT>ccC	p.P589P	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Silent_p.P392P	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	589	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CACTAGAATAAGGGTGACTTC	0.418000													21	28					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138208578	138208578	+	Silent	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:138208578G>T	ENST00000409968.1	+	15	3301	c.3123G>T	c.(3121-3123)ctG>ctT	p.L1041L	THSD7B_ENST00000272643.3_Silent_p.L1041L|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Silent_p.L1010L					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTCCCAAACTGGATCTCAAGA	0.373000													12	8					3.07112e-06	3.20464e-06	1	1	0
OR56A4	120793	broad.mit.edu	37	11	6023879	6023879	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:6023879G>T	ENST00000330728.4	-	1	545	c.500C>A	c.(499-501)tCc>tAc	p.S167Y		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAACGTGCAGGACTCCATGGT	0.522000													47	57					7.05121e-23	8.21501e-23	1	1	0
GPRC5B	51704	broad.mit.edu	37	16	19873158	19873158	+	Splice_Site	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr16:19873158C>T	ENST00000300571.2	-	3	1359		c.e3+1		GPRC5B_ENST00000537135.1_Splice_Site|GPRC5B_ENST00000569847.1_Splice_Site|GPRC5B_ENST00000569479.1_Splice_Site|GPRC5B_ENST00000535671.1_Splice_Site	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B											breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TTGATACTTACGGTCCCACCG	0.552000													73	89					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50719902	50719902	+	Silent	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr22:50719902C>A	ENST00000449103.1	-	22	3689	c.3549G>T	c.(3547-3549)gtG>gtT	p.V1183V	PLXNB2_ENST00000359337.4_Silent_p.V1183V			O15031	PLXB2_HUMAN	plexin B2	1183					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCGGCCCAGCACCCACTCGC	0.682000													9	23					0.000442599	0.000457861	1	1	0
KIAA1551	55196	broad.mit.edu	37	12	32137642	32137642	+	Silent	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:32137642A>G	ENST00000312561.4	+	4	4167	c.3753A>G	c.(3751-3753)ctA>ctG	p.L1251L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		TTCCTGAACTACAAGACGACA	0.363000													30	38					0	0	1	0	0
STX6	10228	broad.mit.edu	37	1	180959233	180959233	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:180959233C>T	ENST00000258301.5	-	5	613	c.376G>A	c.(376-378)Gac>Aac	p.D126N	STX6_ENST00000542060.1_Missense_Mutation_p.D25N	NM_005819.4	NP_005810.1	O43752	STX6_HUMAN	syntaxin 6	126					Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	10						CTGCCACTGTCTCCCAGCAGT	0.468000													24	120					0	0	1	0	0
POLA1	5422	broad.mit.edu	37	X	24746020	24746020	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:24746020G>T	ENST00000379068.3	+	15	1696	c.1653G>T	c.(1651-1653)aaG>aaT	p.K551N	POLA1_ENST00000379059.3_Missense_Mutation_p.K545N|POLA1_ENST00000493342.1_3'UTR			P09884	DPOLA_HUMAN	polymerase (DNA directed), alpha 1, catalytic subunit	545					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|skin(2)	11					Clofarabine(DB00631)|Fludarabine(DB01073)	TCAGCATGAAGACAATGCAGA	0.423000													27	36					6.36457e-07	6.75884e-07	1	1	0
RICTOR	253260	broad.mit.edu	37	5	38950137	38950137	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:38950137C>T	ENST00000357387.3	-	31	3843	c.3813G>A	c.(3811-3813)acG>acA	p.T1271T	RICTOR_ENST00000296782.5_Silent_p.T1271T	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1271					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TAGACTGTGGCGTCAAATAGT	0.453000													83	100					0	0	1	0	0
YIPF6	286451	broad.mit.edu	37	X	67731778	67731778	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:67731778T>C	ENST00000462683.1	+	2	889	c.145T>C	c.(145-147)Ttt>Ctt	p.F49L	YIPF6_ENST00000470730.1_3'UTR|YIPF6_ENST00000374622.2_Intron	NM_173834.3	NP_776195.2	Q96EC8	YIPF6_HUMAN	Yip1 domain family, member 6	49						endoplasmic reticulum|integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(1)	7						CATCCGGGAGTTTGACAGCTC	0.418000													61	91					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922122	5922122	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr9:5922122C>T	ENST00000399933.3	-	8	3873	c.3874G>A	c.(3874-3876)Gta>Ata	p.V1292I	KIAA2026_ENST00000381461.2_Missense_Mutation_p.V1262I	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1292										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TGTACTTTTACAACTCCAGTG	0.428000													40	28					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87079361	87079361	+	Silent	SNP	T	T	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr7:87079361T>A	ENST00000265723.4	-	8	867	c.756A>T	c.(754-756)gcA>gcT	p.A252A	ABCB4_ENST00000545634.1_Silent_p.A252A|ABCB4_ENST00000453593.1_Silent_p.A252A|ABCB4_ENST00000359206.3_Silent_p.A252A|ABCB4_ENST00000358400.3_Silent_p.A252A	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	252	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCACGGCGCCTGCTTTTGCAT	0.478000													62	70					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132689528	132689528	+	Silent	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr9:132689528A>G	ENST00000420781.1	-	8	953	c.735T>C	c.(733-735)atT>atC	p.I245I	FNBP1_ENST00000446176.2_Silent_p.I245I|FNBP1_ENST00000355681.3_Silent_p.I245I			Q96RU3	FNBP1_HUMAN	formin binding protein 1	245	Interaction with microtubules (By similarity).|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		GGCACTTCCCAATGATTGGGA	0.413000			T	MLL	AML								115	196					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49935887	49935887	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr19:49935887G>A	ENST00000221485.3	-	9	1210	c.1039C>T	c.(1039-1041)Ccc>Tcc	p.P347S	SLC17A7_ENST00000600601.1_Missense_Mutation_p.P280S|SLC17A7_ENST00000543531.1_Missense_Mutation_p.P335S	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	347					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		ACCAGGTGGGGCAGCGCGGAC	0.677000													18	2					0	0	1	0	0
FOXD3	27022	broad.mit.edu	37	1	63789368	63789368	+	Silent	SNP	C	C	T	rs114453593	byFrequency	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:63789368C>T	ENST00000371116.2	+	1	639	c.639C>T	c.(637-639)aaC>aaT	p.N213N	RP4-792G4.2_ENST00000427268.1_RNA	NM_012183.2	NP_036315.1	Q9UJU5	FOXD3_HUMAN	forkhead box D3	213					axon extension involved in axon guidance|branching involved in ureteric bud morphogenesis|cartilage development|embryonic placenta development|enteric nervous system development|iridophore differentiation|kidney development|lateral line nerve glial cell development|melanocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development|trophectodermal cell differentiation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|lung(2)|upper_aerodigestive_tract(1)	5						GCAAGGGCAACTACTGGACCC	0.647000													9	197					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348670	197348670	+	RNA	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr3:197348670G>T	ENST00000418868.1	-	0	589					NR_003266.2																						TTGAGGCTCTGTCCACCAAAT	0.478000													62	93					1.85135e-42	2.41481e-42	1	1	0
VSIG2	23584	broad.mit.edu	37	11	124617482	124617482	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:124617482C>T	ENST00000326621.5	-	7	1033	c.933G>A	c.(931-933)tcG>tcA	p.S311S	NRGN_ENST00000526916.2_3'UTR	NM_014312.3	NP_055127.2	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	311				Missing (in Ref. 1; AAD17522).		integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		TGCTGGCAGACGAGGGTCTTT	0.542000													12	84					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231612	230231612	+	Silent	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:230231612G>A	ENST00000341772.4	-	12	2213	c.2079C>T	c.(2077-2079)gcC>gcT	p.A693A		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	693					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGGATGCAATGGCATTGCTGA	0.552000													46	55					0	0	1	0	0
SH2B2	10603	broad.mit.edu	37	7	101944511	101944511	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr7:101944511G>A	ENST00000536178.1	+	2	851	c.806G>A	c.(805-807)cGc>cAc	p.R269H	SH2B2_ENST00000306803.8_Missense_Mutation_p.R226H			O14492	SH2B2_HUMAN	SH2B adaptor protein 2	226	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9						CTGCTCCTGCGCAGGGCTGTG	0.682000													3	6					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72502814	72502814	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr15:72502814A>T	ENST00000319622.6	-	4	708	c.252T>A	c.(250-252)caT>caA	p.H84Q	PKM_ENST00000389093.3_Missense_Mutation_p.H84Q|PKM_ENST00000335181.5_Missense_Mutation_p.H84Q|PKM_ENST00000449901.2_Missense_Mutation_p.H69Q|PKM_ENST00000568883.1_Intron|PKM_ENST00000568459.1_Missense_Mutation_p.H84Q|PKM_ENST00000565154.1_Missense_Mutation_p.H84Q|PKM_ENST00000565184.1_Missense_Mutation_p.H84Q	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						TGGTCTCCGCATGGTACTGGG	0.547000													30	70					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119133	3119133	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr17:3119133C>A	ENST00000304094.1	+	1	219	c.219C>A	c.(217-219)ttC>ttA	p.F73L		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						ACATCTTCTTCTCATCGGTAA	0.478000													117	141					1.81606e-51	2.42141e-51	1	1	0
ADAM7	8756	broad.mit.edu	37	8	24324450	24324450	+	Silent	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr8:24324450C>A	ENST00000175238.6	+	6	611	c.528C>A	c.(526-528)acC>acA	p.T176T	RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Silent_p.T176T|ADAM7_ENST00000441335.2_Silent_p.T176T|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	176					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTAATTTTACCAGAAAAACTG	0.353000													43	55					5.78141e-17	6.545e-17	1	1	0
WDFY3	23001	broad.mit.edu	37	4	85630181	85630181	+	Splice_Site	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr4:85630181T>C	ENST00000322366.6	-	52	8454	c.8046_splice	c.e52-1	p.R2683_splice	WDFY3_ENST00000295888.4_Splice_Site_p.R2700_splice			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2700	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATTTCACCTCTCTGGAAAAAG	0.333000													48	63					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54956904	54956904	+	Silent	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:54956904C>T	ENST00000173898.7	+	12	3859	c.3747C>T	c.(3745-3747)ttC>ttT	p.F1249F	TRO_ENST00000375041.2_Silent_p.F852F|TRO_ENST00000420798.2_Silent_p.F780F|TRO_ENST00000399736.1_Intron|TRO_ENST00000319167.8_Intron|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1249	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GCGCTGGCTTCGGTGGAGGAC	0.617000													12	127					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128486043	128486043	+	Splice_Site	SNP	G	G	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr7:128486043G>C	ENST00000325888.8	+	22	4051		c.e22-1		FLNC_ENST00000346177.6_Splice_Site	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma						cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CTGGGCTCCAGGTGTCCTGCG	0.637000													11	22					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79423698	79423698	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr14:79423698G>T	ENST00000554719.1	+	8	1761	c.1270G>T	c.(1270-1272)Gct>Tct	p.A424S	NRXN3_ENST00000335750.5_Missense_Mutation_p.A424S	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGATGATGTGGCTGAGGGTGA	0.468000													30	64					2.61193e-14	2.90215e-14	1	1	0
EMILIN2	84034	broad.mit.edu	37	18	2892185	2892185	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr18:2892185C>T	ENST00000254528.3	+	4	2219	c.2060C>T	c.(2059-2061)gCt>gTt	p.A687V		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	687					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		GAGCTGGATGCTTGTAAGGAA	0.597000													65	97					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37347768	37347768	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr17:37347768C>T	ENST00000394303.3	-	3	457	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K	CACNB1_ENST00000394310.3_Missense_Mutation_p.E84K|CACNB1_ENST00000344140.5_Missense_Mutation_p.E84K|CACNB1_ENST00000582877.1_5'UTR	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	84					axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CGCTCTGCTTCCTTCCTTAAG	0.572000													29	40					0	0	1	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800041	74800041	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr11:74800041C>A	ENST00000305159.3	-	1	758	c.718G>T	c.(718-720)Gca>Tca	p.A240S		NM_001005285.1	NP_001005285.1	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT, member 4	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	12						AAGGCTTTTGCCCGTCCTTCT	0.582000													23	29					3.8784e-16	4.34961e-16	1	1	0
IGHG3	3502	broad.mit.edu	37	14	106237030	106237030	+	RNA	SNP	T	T	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr14:106237030T>G	ENST00000390551.2	-	0	320																											CATGTGTGAGTTGTGTCACCA	0.567000													68	101					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060940	189060940	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr4:189060940C>A	ENST00000332517.3	+	1	368	c.228C>A	c.(226-228)agC>agA	p.S76R		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	76					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGCTGGCCAGCATCGCCAGGC	0.627000													50	74					1.86633e-21	2.15346e-21	1	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299867	125299867	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chrX:125299867G>T	ENST00000538699.1	-	2	121	c.41C>A	c.(40-42)cCc>cAc	p.P14H	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.P14H	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	14										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CTCGACCGCGGGCGCTTTCCG	0.751000													12	23					4.3838e-07	4.69693e-07	1	1	0
OR1A1	8383	broad.mit.edu	37	17	3119132	3119132	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr17:3119132T>C	ENST00000304094.1	+	1	218	c.218T>C	c.(217-219)tTc>tCc	p.F73S		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						GACATCTTCTTCTCATCGGTA	0.478000													118	141					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882791	152882791	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:152882791T>G	ENST00000368764.3	+	2	582	c.518T>G	c.(517-519)cTg>cGg	p.L173R	IVL_ENST00000392667.2_Missense_Mutation_p.L27R			P07476	INVO_HUMAN	involucrin	173	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			gagggacagctgaagcacccg	0.627000													5	33					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602543	10602543	+	Nonsense_Mutation	SNP	G	G	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr19:10602543G>C	ENST00000171111.5	-	3	1582	c.1035C>G	c.(1033-1035)taC>taG	p.Y345*	KEAP1_ENST00000393623.2_Nonsense_Mutation_p.Y345*	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CACTGGGGTTGTAAGCCTCCA	0.716000													11	3					0	0	1	0	0
ZNF320	162967	broad.mit.edu	37	19	53367338	53367338	+	Missense_Mutation	SNP	G	G	A	rs4803014	by1000genomes	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr19:53367338G>A	ENST00000597909.1	-	6	534	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C				A2RRD8	ZN320_HUMAN	zinc finger protein 320	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		TGTATAAAGCGTTCTGTGCAG	0.448000													4	41					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16528913	16528913	+	Silent	SNP	C	C	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:16528913C>A	ENST00000270747.3	-	13	2200	c.2064G>T	c.(2062-2064)acG>acT	p.T688T	ARHGEF19_ENST00000421561.1_Intron|ARHGEF19_ENST00000478117.1_5'UTR	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	688	PH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CCACTCACTCCGTCCGGGCCC	0.682000													3	22					0.115264	0.115264	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40728853	40728853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:40728853G>T	ENST00000298910.7	+	40	5900	c.5842G>T	c.(5842-5844)Gag>Tag	p.E1948*		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1948	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTTGGTGATGGAGTTAGCCTC	0.542000													40	69					4.07013e-28	5.03521e-28	1	1	0
PCDHGC5	56097	broad.mit.edu	37	5	140871239	140871239	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:140871239G>A	ENST00000252087.1	+	1	2432	c.2432G>A	c.(2431-2433)cGc>cAc	p.R811H	PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		811					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCGGTCCCGCTCTAATACG	0.677000													3	24					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17804715	17804715	+	Silent	SNP	A	A	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr6:17804715A>G	ENST00000378814.5	-	20	2330	c.2331T>C	c.(2329-2331)ggT>ggC	p.G777G	KIF13A_ENST00000378816.5_Silent_p.G777G|KIF13A_ENST00000378843.2_Silent_p.G777G|KIF13A_ENST00000378826.2_Silent_p.G777G|KIF13A_ENST00000259711.6_Silent_p.G777G	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	777					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AGAAAGGGTCACCTCGTTTTC	0.413000													3	19					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11942769	11942769	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr19:11942769G>C	ENST00000304060.5	+	4	942	c.778G>C	c.(778-780)Gag>Cag	p.E260Q		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TGAATATCAGGAGTGTGGGAA	0.383000													44	16					0	0	1	0	0
SMCO3	440087	broad.mit.edu	37	12	14959334	14959334	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:14959334G>T	ENST00000316048.2	-	2	353	c.281C>A	c.(280-282)aCc>aAc	p.T94N	C12orf60_ENST00000527783.1_Intron|C12orf60_ENST00000330828.2_Intron	NM_001013698.2	NP_001013720.2			single-pass membrane protein with coiled-coil domains 3																		TCTATAGAGGGTTGGCTCTAG	0.383000													48	82					2.68985e-26	3.29369e-26	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96106276	96106276	+	Silent	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr4:96106276G>T	ENST00000453304.1	-	13	2556	c.2208C>A	c.(2206-2208)ggC>ggA	p.G736G		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	736					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGTGGGTGCTGCCTTTAAAAT	0.463000													68	102					1.31726e-23	1.56506e-23	1	1	0
ASTN1	460	broad.mit.edu	37	1	177133540	177133540	+	Silent	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:177133540G>A	ENST00000367654.2	-	1	286	c.273C>T	c.(271-273)taC>taT	p.Y91Y	ASTN1_ENST00000361833.2_Silent_p.Y91Y|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Silent_p.Y91Y|ASTN1_ENST00000424564.2_Silent_p.Y91Y			O14525	ASTN1_HUMAN	astrotactin 1	91					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCAGCACGAAGTAGGGCAGCT	0.697000													13	32					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	191861870	191861870	+	Silent	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr3:191861870T>C	ENST00000454309.2	-	5	1485	c.660A>G	c.(658-660)caA>caG	p.Q220Q	FGF12_ENST00000430714.1_Silent_p.Q121Q|FGF12_ENST00000450716.1_Silent_p.Q158Q|FGF12_ENST00000445105.1_Silent_p.Q158Q|FGF12_ENST00000264730.3_Silent_p.Q158Q	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	220					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTGAACGCCCTTGTTTTTCTC	0.393000													91	147					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58117187	58117187	+	Silent	SNP	A	A	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr19:58117187A>C	ENST00000332854.6	+	3	514	c.294A>C	c.(292-294)ccA>ccC	p.P98P	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTGTACCCCAGTCCTGAGAG	0.473000													8	86					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225592188	225592188	+	Silent	SNP	T	T	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:225592188T>C	ENST00000338179.2	-	13	1730	c.1605A>G	c.(1603-1605)ctA>ctG	p.L535L	LBR_ENST00000272163.4_Silent_p.L535L	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	535					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		ATCCAGAAACTAGAAGATTTT	0.378000													17	74					0	0	1	0	0
KIF20A	10112	broad.mit.edu	37	5	137521326	137521326	+	Silent	SNP	C	C	T	rs144189626	byFrequency	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr5:137521326C>T	ENST00000394894.3	+	16	2278	c.2052C>T	c.(2050-2052)gcC>gcT	p.A684A	KIF20A_ENST00000508792.1_Silent_p.A666A	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	684					cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGCTTCTGCCTCCACCCAGC	0.512000													8	80					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200959157	200959157	+	Silent	SNP	G	G	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:200959157G>C	ENST00000332129.2	-	21	3361	c.3045C>G	c.(3043-3045)tcC>tcG	p.S1015S	KIF21B_ENST00000360529.5_Silent_p.S1015S|KIF21B_ENST00000422435.2_Silent_p.S1015S|KIF21B_ENST00000461742.2_Silent_p.S1015S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1015					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ATGTGTCTGTGGAGTCCAGCT	0.647000													20	116					0	0	1	0	0
PVALB	5816	broad.mit.edu	37	22	37209741	37209741	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr22:37209741T>A	ENST00000216200.5	-	4	308	c.253A>T	c.(253-255)Atg>Ttg	p.M85L	PVALB_ENST00000417718.2_Missense_Mutation_p.M85L|PVALB_ENST00000404171.1_Missense_Mutation_p.M53L	NM_002854.2	NP_002845.1	P20472	PRVA_HUMAN	parvalbumin	85	EF-hand 2.						calcium ion binding			large_intestine(1)|lung(1)|skin(1)	3						GCCATCAGCATCTTGGTTTCT	0.547000													83	112					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88259733	88259733	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr10:88259733C>T	ENST00000298767.5	-	3	1739	c.1267G>A	c.(1267-1269)Gat>Aat	p.D423N		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	423	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AGTTTAACATCCTTTTTGGAT	0.353000													28	60					0	0	1	0	0
PPP3CA	5530	broad.mit.edu	37	4	101947148	101947148	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr4:101947148A>C	ENST00000394854.3	-	14	2123	c.1440T>G	c.(1438-1440)aaT>aaG	p.N480K	PPP3CA_ENST00000512215.1_Missense_Mutation_p.N248K|PPP3CA_ENST00000394853.4_Missense_Mutation_p.N470K|PPP3CA_ENST00000323055.6_Missense_Mutation_p.N428K|PPP3CA_ENST00000507176.1_Missense_Mutation_p.N382K|PPP3CA_ENST00000523694.2_Missense_Mutation_p.N413K	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	480	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GCATCCTCTCATTAATTCGGT	0.458000													74	101					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188249	152188249	+	Silent	SNP	G	G	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:152188249G>T	ENST00000368801.2	-	3	5931	c.5856C>A	c.(5854-5856)ggC>ggA	p.G1952G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1952					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCCATGTCGGCCACGGCTAG	0.617000													124	1098					1.24833e-42	1.64615e-42	1	1	0
EFHD1	80303	broad.mit.edu	37	2	233527526	233527526	+	Missense_Mutation	SNP	G	G	T	rs142523596	byFrequency	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:233527526G>T	ENST00000264059.3	+	2	794	c.317G>T	c.(316-318)cGg>cTg	p.R106L	EFHD1_ENST00000410095.1_5'UTR|EFHD1_ENST00000409708.1_5'UTR|EFHD1_ENST00000409613.1_Missense_Mutation_p.R10L	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	106	EF-hand 1.						calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		GACGCTGGGCGGGATGGCTTC	0.542000													16	33					2.48551e-13	2.68703e-13	1	1	0
PPP1R21	129285	broad.mit.edu	37	2	48688354	48688354	+	Missense_Mutation	SNP	T	T	C	rs150896282		TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:48688354T>C	ENST00000294952.8	+	7	834	c.677T>C	c.(676-678)gTa>gCa	p.V226A	PPP1R21_ENST00000449090.2_Missense_Mutation_p.V226A|PPP1R21_ENST00000281394.4_Missense_Mutation_p.V226A	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	226										endometrium(2)|kidney(4)|lung(9)	15						AATGAAAAAGTACCTTTTAAT	0.274000													4	45					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757414	8757414	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:8757414G>A	ENST00000229335.6	-	4	635	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	AICDA_ENST00000537228.1_Missense_Mutation_p.R168C	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	178					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding	p.R178C(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AAAAGGATGCGCCGAAGCTGT	0.378000													89	111					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965324	88965324	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr7:88965324C>T	ENST00000333190.4	+	4	3637	c.3028C>T	c.(3028-3030)Cac>Tac	p.H1010Y		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1010						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAAAAGTTCACACACAAATAA	0.343000										HNSCC(36;0.09)			21	53					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61689414	61689414	+	Silent	SNP	G	G	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr16:61689414G>A	ENST00000577390.1	-	11	2820	c.1866C>T	c.(1864-1866)ggC>ggT	p.G622G	CDH8_ENST00000299345.6_Silent_p.G622G|CDH8_ENST00000577730.1_Silent_p.G622G	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	622					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G622G(2)		biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CAATTAAGGCGCCCATACTGA	0.448000													60	62					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97856868	97856868	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr2:97856868C>G	ENST00000420699.2	+	36	2541	c.2297C>G	c.(2296-2298)tCt>tGt	p.S766C	ANKRD36_ENST00000461153.2_Missense_Mutation_p.S766C	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	766										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						GAGAAAGATTCTGTTTCGAAC	0.299000													6	10					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150530506	150530506	+	Frame_Shift_Del	DEL	G	G	-	rs149280379		TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:150530506delG	ENST00000271643.4	+	14	2499	c.2263delG	c.(2263-2265)ggfs	p.G758fs	ADAMTSL4_ENST00000369041.5_Frame_Shift_Del_p.G758fs|ADAMTSL4_ENST00000369039.5_Frame_Shift_Del_p.G781fs|ADAMTSL4_ENST00000369038.2_Frame_Shift_Del_p.G758fs	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	758	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCAGGAATTTGGGGGGGGTGG	0.692													7	278	---	---	---	---					
CCT3	7203	broad.mit.edu	37	1	156280743	156280744	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:156280743_156280744delGA	ENST00000295688.3	-	12	1678_1679	c.1398_1399delTC	c.(1396-1401)ctggfs	p.LR466fs	CCT3_ENST00000472765.2_Frame_Shift_Del_p.LR421fs|CCT3_ENST00000368259.2_Frame_Shift_Del_p.LR428fs|CCT3_ENST00000368261.3_Frame_Shift_Del_p.LR421fs	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	466					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GAACTCACCCGAAGGGAGGTAA	0.515													34	124	---	---	---	---					
RYR2	6262	broad.mit.edu	37	1	237886443	237886444	+	Frame_Shift_Ins	INS	-	-	T			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr1:237886443_237886444insT	ENST00000366574.2	+	74	10887_10888	c.10570_10571insT	c.(10570-10572)tagfs	p.*3524fs	RYR2_ENST00000542537.1_Frame_Shift_Ins_p.*3508fs|RYR2_ENST00000360064.6_Frame_Shift_Ins_p.*3522fs	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3524					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGATCCTGCTATTAGATGGCAA	0.396													8	392	---	---	---	---					
KRT84	3890	broad.mit.edu	37	12	52777428	52777429	+	Frame_Shift_Ins	INS	-	-	G	rs138666354	byFrequency	TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr12:52777428_52777429insG	ENST00000257951.3	-	2	766_767	c.700_701insC	c.(700-702)gctfs	p.A234fs	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	234	Coil 1B.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGCCTGGAGCCGGGCCTGATCA	0.569													25	65	---	---	---	---					
HIF1A	3091	broad.mit.edu	37	14	62187197	62187197	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr14:62187197delC	ENST00000394997.1	+	2	401	c.136delC	c.(136-138)cafs	p.P46fs	HIF1A_ENST00000337138.4_Frame_Shift_Del_p.P45fs|HIF1A_ENST00000557206.1_3'UTR|HIF1A_ENST00000539097.1_Frame_Shift_Del_p.P69fs|HIF1A_ENST00000323441.6_Frame_Shift_Del_p.P45fs|HIF1A-AS2_ENST00000554254.1_lincRNA|HIF1A_ENST00000557538.1_5'UTR			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	45	Helix-loop-helix motif.|Interaction with TSGA10 (By similarity).				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TCATCAGTTGCCACTTCCACA	0.438													33	80	---	---	---	---					
UNC13C	440279	broad.mit.edu	37	15	54803996	54803997	+	Frame_Shift_Ins	INS	-	-	A			TCGA-MP-A5C7-01A-11D-A25L-08	TCGA-MP-A5C7-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0649C3EE-C529-43BF-964B-00A19A065644	4184DDEF-341B-48A5-9392-6B2C8F30A825	g.chr15:54803996_54803997insA	ENST00000545554.1	+	23	5425_5426	c.5425_5426insA	c.(5425-5427)aaafs	p.K1809fs	UNC13C_ENST00000537900.1_Frame_Shift_Ins_p.K1807fs|UNC13C_ENST00000260323.11_Frame_Shift_Ins_p.K1809fs			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1809					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGTCCAGCTGGAAAAAATGTTT	0.332													15	14	---	---	---	---					
