Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRT6A	3853	broad.mit.edu	37	12	52886532	52886532	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:52886532G>A	ENST00000330722.6	-	1	509	c.441C>T	c.(439-441)ccC>ccT	p.P147P		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	147	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCAGGTTGAGGGGAGTCAGGA	0.607000													41	167					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63417106	63417106	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:63417106C>A	ENST00000322893.7	-	7	1382	c.1114G>T	c.(1114-1116)Gac>Tac	p.D372Y	KCNH5_ENST00000394964.2_Missense_Mutation_p.D314Y|KCNH5_ENST00000394968.1_Missense_Mutation_p.D314Y|KCNH5_ENST00000420622.2_Missense_Mutation_p.D372Y	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	372					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACCTCGTAGTCTCCGATGCTA	0.507000													54	47					9.72345e-25	1.67029e-24	1	1	0
MIR124-2HG	100130155	broad.mit.edu	37	8	65291727	65291727	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:65291727C>A	ENST00000521441.1	+	0	655				MIR124-2_ENST00000385081.1_RNA																							AGGCTCTGCTCTCCGTGTTCA	0.527000													10	91					6.40141e-05	7.0382e-05	1	1	0
KCNK9	51305	broad.mit.edu	37	8	140630540	140630540	+	Silent	SNP	G	G	T	rs142114452		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:140630540G>T	ENST00000520439.1	-	2	1149	c.1086C>A	c.(1084-1086)acC>acA	p.T362T	KCNK9_ENST00000303015.1_Silent_p.T362T			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	362						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TCTGGTGGTCGGTAAAGCTGT	0.473000													80	131					1.8615e-32	3.45179e-32	1	1	0
OR13A1	79290	broad.mit.edu	37	10	45799232	45799232	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:45799232G>T	ENST00000553795.1	-	4	947	c.639C>A	c.(637-639)aaC>aaA	p.N213K	OR13A1_ENST00000536058.1_Missense_Mutation_p.N213K|OR13A1_ENST00000374401.2_Missense_Mutation_p.N213K	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						TCATGACACCGTTGACGTAGG	0.532000													20	113					3.99206e-14	5.60757e-14	1	1	0
KEL	3792	broad.mit.edu	37	7	142658955	142658955	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142658955C>A	ENST00000355265.2	-	2	482	c.8G>T	c.(7-9)gGt>gTt	p.G3V	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	3					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TTGGTCCCCACCTTCCTGAAG	0.552000													93	151					5.10314e-47	1.011e-46	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48312683	48312683	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:48312683G>T	ENST00000435803.1	+	17	3444	c.3420G>T	c.(3418-3420)aaG>aaT	p.K1140N		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1140					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGTTCAACAAGTTTATGTCCA	0.343000													20	70					9.7654e-05	0.00010667	1	1	0
TGM3	7053	broad.mit.edu	37	20	2321197	2321197	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:2321197G>A	ENST00000381458.5	+	13	2115	c.2052G>A	c.(2050-2052)aaG>aaA	p.K684K		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	684					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CTGCAATCAAGGCCATGTTGT	0.582000													30	31					0	0	1	0	0
B4GALT2	8704	broad.mit.edu	37	1	44450671	44450671	+	Nonsense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:44450671C>G	ENST00000356836.6	+	4	1474	c.684C>G	c.(682-684)taC>taG	p.Y228*	B4GALT2_ENST00000481924.1_3'UTR|B4GALT2_ENST00000434555.2_Nonsense_Mutation_p.Y162*|B4GALT2_ENST00000309519.7_Nonsense_Mutation_p.Y257*|B4GALT2_ENST00000372324.1_Nonsense_Mutation_p.Y228*	NM_001005417.2|NM_030587.2	NP_001005417.1|NP_085076.2	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	228					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GCAACCTATACCGCTGCGGCG	0.602000													10	22					0	0	1	0	0
AMY2B	280	broad.mit.edu	37	1	104114790	104114790	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:104114790G>T	ENST00000361355.4	+	4	843	c.227G>T	c.(226-228)aGa>aTa	p.R76I	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	76					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TGGTGGGAAAGATACCAACCA	0.358000													50	189					1.56989e-16	2.34646e-16	1	1	0
PKD2	5311	broad.mit.edu	37	4	88989137	88989137	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:88989137G>A	ENST00000237596.2	+	13	2512	c.2446G>A	c.(2446-2448)Gac>Aac	p.D816N	PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000508588.1_Missense_Mutation_p.D234N|PKD2_ENST00000502363.1_Missense_Mutation_p.D234N	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	816	Linker.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TGAGGAGGATGACGATGAAGA	0.478000													21	108					0	0	1	0	0
GMEB1	10691	broad.mit.edu	37	1	29018099	29018099	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:29018099A>C	ENST00000373816.1	+	4	352	c.214A>C	c.(214-216)Aca>Cca	p.T72P	GMEB1_ENST00000294409.2_Missense_Mutation_p.T82P|GMEB1_ENST00000361872.4_Missense_Mutation_p.T72P|GMEB1_ENST00000480454.1_3'UTR	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GTTTTCAGATACAGGCACTAT	0.398000													15	71					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33570326	33570326	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:33570326G>C	ENST00000262873.7	+	8	810	c.718G>C	c.(718-720)Gct>Cct	p.A240P		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	198	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGCCATCGTCGCTGCCCTGGG	0.567000													33	16					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090305	238090305	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:238090305C>A	ENST00000450451.1	+	0	1811					NR_027247.2																						CGACAAGGCCCAGAGCAAGCC	0.587000													9	62					3.09899e-07	3.6664e-07	1	1	0
CHD1L	9557	broad.mit.edu	37	1	146747131	146747131	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:146747131A>T	ENST00000369258.4	+	13	1405	c.1385_splice	c.e13+1	p.K462_splice	CHD1L_ENST00000431239.1_Splice_Site_p.K368_splice|CHD1L_ENST00000361293.5_Splice_Site_p.K181_splice|CHD1L_ENST00000467213.1_3'UTR|CHD1L_ENST00000369259.3_Splice_Site_p.K258_splice	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	462	Helicase C-terminal.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					GGCCAAAACAAGTAAGTGATT	0.453000													35	93					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15614353	15614353	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:15614353G>T	ENST00000378076.3	-	25	2847	c.2494C>A	c.(2494-2496)Cca>Aca	p.P832T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	832					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						ATGGTACTTGGTCCAATATTG	0.428000													76	83					2.08937e-45	4.09108e-45	1	1	0
BRAT1	221927	broad.mit.edu	37	7	2577951	2577951	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:2577951T>A	ENST00000340611.4	-	14	2474	c.2218A>T	c.(2218-2220)Agg>Tgg	p.R740W		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	740					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						GGGCTGCCCCTGGCCTCCCGC	0.667000													20	66					0	0	1	0	0
C3orf70	285382	broad.mit.edu	37	3	184801030	184801030	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:184801030C>T	ENST00000335012.2	-	2	708	c.518G>A	c.(517-519)aGc>aAc	p.S173N		NM_001025266.1	NP_001020437.1	A6NLC5	CC070_HUMAN	chromosome 3 open reading frame 70	173										breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|urinary_tract(1)	13						TGGTGTATTGCTCTCTTTTGA	0.488000													21	89					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15818106	15818106	+	Nonstop_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:15818106T>C	ENST00000396355.1	+	10	1832	c.1006T>C	c.(1006-1008)Tga>Cga	p.*336R	MYH11_ENST00000300036.5_Missense_Mutation_p.Q1426R|MYH11_ENST00000452625.2_Missense_Mutation_p.Q1433R|MYH11_ENST00000396324.3_Missense_Mutation_p.Q1433R|MYH11_ENST00000576790.1_Missense_Mutation_p.Q1426R|NDE1_ENST00000396354.1_Nonstop_Mutation_p.*336R|MYH11_ENST00000338282.6_Missense_Mutation_p.Q1426R|NDE1_ENST00000342673.5_Nonstop_Mutation_p.*336R|NDE1_ENST00000571896.1_3'UTR	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	0					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						CAGCTCCTGCTGAAGCCTGTT	0.522000													20	54					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66938152	66938152	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:66938152C>A	ENST00000269080.2	-	2	161	c.24G>T	c.(22-24)gtG>gtT	p.V8V	ABCA8_ENST00000586539.1_Silent_p.V8V|ABCA8_ENST00000430352.2_Silent_p.V8V	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	8						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TTTGTTGACACACACTGATCT	0.308000													34	85					9.17885e-22	1.48846e-21	1	1	0
GSR	2936	broad.mit.edu	37	8	30550566	30550566	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:30550566T>A	ENST00000221130.5	-	8	892	c.802A>T	c.(802-804)Aga>Tga	p.R268*	GSR_ENST00000541648.1_Nonsense_Mutation_p.R268*|GSR_ENST00000414019.1_Nonsense_Mutation_p.R225*|GSR_ENST00000537535.1_Intron|GSR_ENST00000546342.1_Intron	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	268					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TCAAAACTTCTAAGTACCTGC	0.493000													9	27					0	0	1	0	0
GPR88	54112	broad.mit.edu	37	1	101004809	101004809	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:101004809C>T	ENST00000315033.4	+	2	726	c.287C>T	c.(286-288)aCc>aTc	p.T96I		NM_022049.2	NP_071332.2	Q9GZN0	GPR88_HUMAN	G protein-coupled receptor 88	96						integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|skin(1)	3		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		CTCCTGCCCACCGGCTCTGCG	0.726000													5	3					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40949552	40949552	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:40949552G>T	ENST00000346991.5	+	25	7062		c.e25-1		CASC5_ENST00000399668.2_Splice_Site			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5						acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		ACTTTTTCTAGATGCTTGAAG	0.343000													23	87					6.32553e-13	8.6821e-13	1	1	0
CCDC108	255101	broad.mit.edu	37	2	219886553	219886553	+	Missense_Mutation	SNP	G	G	A	rs144604393	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:219886553G>A	ENST00000341552.5	-	18	3162	c.3079C>T	c.(3079-3081)Cgc>Tgc	p.R1027C	CCDC108_ENST00000441968.1_Missense_Mutation_p.R1027C|CCDC108_ENST00000453220.1_Missense_Mutation_p.R1027C	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1027						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGTAGAGGCGGTAATAGAGG	0.607000													30	165					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23119382	23119382	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:23119382G>T	ENST00000219689.7	-	2	755	c.756C>A	c.(754-756)ggC>ggA	p.G252G		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	252					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GAGGAGGCTGGCCACTCTGCT	0.517000													26	105					9.57634e-11	1.24138e-10	1	1	0
NOX3	50508	broad.mit.edu	37	6	155743913	155743913	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:155743913C>A	ENST00000159060.2	-	10	1325	c.1223G>T	c.(1222-1224)gGg>gTg	p.G408V		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	408							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GACTCCGATCCCCGCGGCAAC	0.527000													51	63					4.25531e-23	7.09219e-23	1	1	0
CHRM2	1129	broad.mit.edu	37	7	136700532	136700532	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:136700532C>A	ENST00000445907.2	+	3	1448	c.920C>A	c.(919-921)aCa>aAa	p.T307K	AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.T307K|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.T307K|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.T307K|CHRM2_ENST00000320658.5_Missense_Mutation_p.T307K|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000592183.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.T307K	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	307					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GATGAAAACACAGTTTCCACT	0.463000													23	118					2.89027e-11	3.78756e-11	1	1	0
TPO	7173	broad.mit.edu	37	2	1544421	1544421	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:1544421C>T	ENST00000345913.4	+	16	2765	c.2674C>T	c.(2674-2676)Ccc>Tcc	p.P892S	TPO_ENST00000382198.1_Missense_Mutation_p.P719S|TPO_ENST00000497517.2_Intron|TPO_ENST00000337415.3_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.P848S|TPO_ENST00000329066.4_Missense_Mutation_p.P892S|TPO_ENST00000349624.3_Missense_Mutation_p.P719S|TPO_ENST00000382201.3_Missense_Mutation_p.P835S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	892					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.P892S(1)		breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGGAGGAACTCCCGAGCTGAG	0.642000													18	69					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188228229	188228229	+	Splice_Site	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:188228229C>G	ENST00000409998.1	-	10	1282	c.500_splice	c.e10-1	p.K167_splice	CALCRL_ENST00000392370.3_Splice_Site_p.K167_splice|CALCRL_ENST00000410068.1_Splice_Site_p.K167_splice|AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	167						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			AACTTAGGCTCCTAAAAAGCA	0.343000													8	83					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31334279	31334279	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:31334279C>G	ENST00000542188.1	-	16	2326	c.2013G>C	c.(2011-2013)tgG>tgC	p.W671C	RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000397795.2_Missense_Mutation_p.W632C|TRPM1_ENST00000256552.6_Missense_Mutation_p.W654C	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	632					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CCCCTCGCTGCCAGAGGAACA	0.587000													22	24					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142160995	142160995	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:142160995C>A	ENST00000519811.1	+	6	868	c.798C>A	c.(796-798)atC>atA	p.I266I	DENND3_ENST00000424248.1_Silent_p.I186I|DENND3_ENST00000262585.2_Silent_p.I186I			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	186	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AAAGCCCCATCCTGGACCTGG	0.597000													20	199					8.10497e-08	9.78186e-08	1	1	0
RIMS2	9699	broad.mit.edu	37	8	104897683	104897683	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:104897683G>A	ENST00000507740.1	+	2	516	c.280G>A	c.(280-282)Gaa>Aaa	p.E94K	RIMS2_ENST00000436393.2_Missense_Mutation_p.E64K|RIMS2_ENST00000406091.3_Missense_Mutation_p.E286K|RIMS2_ENST00000262231.10_Missense_Mutation_p.E94K|RIMS2_ENST00000522174.1_3'UTR	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	317	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCAGTTTTATGAAGACTCTGA	0.398000										HNSCC(12;0.0054)			62	165					0	0	1	0	0
FAM177B	400823	broad.mit.edu	37	1	222923346	222923346	+	Silent	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:222923346G>C	ENST00000445590.2	+	6	689	c.423G>C	c.(421-423)ggG>ggC	p.G141G	FAM177B_ENST00000360827.2_Silent_p.G141G	NM_207468.2	NP_997351.2	A6PVY3	F177B_HUMAN	family with sequence similarity 177, member B	141										breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	8						TGGAGGCTGGGGTCCAAGAGT	0.488000													43	63					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99663435	99663435	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:99663435T>C	ENST00000373034.4	-	1	1836	c.161A>G	c.(160-162)gAc>gGc	p.D54G	PCDH19_ENST00000255531.7_Missense_Mutation_p.D54G|PCDH19_ENST00000420881.2_Missense_Mutation_p.D54G	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	54	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CTGCCGGGGGTCCAGCGCGAA	0.612000													7	21					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94767281	94767281	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:94767281G>T	ENST00000453321.3	+	1	197	c.139G>T	c.(139-141)Gag>Tag	p.E47*	TMEM67_ENST00000409623.3_5'UTR	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	47					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			CCAGCAGCCGGAGAAGTGCGA	0.567000													84	276					2.43516e-34	4.55576e-34	1	1	0
CTNND2	1501	broad.mit.edu	37	5	11159742	11159742	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:11159742C>A	ENST00000304623.8	-	12	2294	c.2105G>T	c.(2104-2106)cGg>cTg	p.R702L	CTNND2_ENST00000503622.1_Missense_Mutation_p.R365L|CTNND2_ENST00000458100.2_Missense_Mutation_p.R269L|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.R611L|CTNND2_ENST00000359640.2_Missense_Mutation_p.R702L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	702					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CTGTATTTTCCGATCATCCTG	0.552000													22	169					3.83957e-06	4.40005e-06	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141680702	141680702	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:141680702C>A	ENST00000389484.3	-	21	4122	c.3151G>T	c.(3151-3153)Gct>Tct	p.A1051S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1051					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTACAACCAGCAGGAGAATGA	0.408000										TSP Lung(27;0.18)			37	30					2.87052e-16	4.27524e-16	1	1	0
DRAP1	10589	broad.mit.edu	37	11	65687872	65687872	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:65687872G>T	ENST00000312515.2	+	4	513	c.268G>T	c.(268-270)Gtt>Ttt	p.V90F	DRAP1_ENST00000527119.1_Missense_Mutation_p.V46F|DRAP1_ENST00000532933.1_Missense_Mutation_p.V70F|DRAP1_ENST00000376991.2_Missense_Mutation_p.V90F	NM_006442.3	NP_006433.2	Q14919	NC2A_HUMAN	DR1-associated protein 1 (negative cofactor 2 alpha)	90					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(1)	5				READ - Rectum adenocarcinoma(159;0.166)		GGTGGCATCTGTTCCCGACAT	0.632000													22	103					7.87624e-14	1.10452e-13	1	1	0
LRRC42	115353	broad.mit.edu	37	1	54423866	54423866	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:54423866G>C	ENST00000371370.3	+	4	1039	c.518G>C	c.(517-519)cGg>cCg	p.R173P	LRRC42_ENST00000319223.4_Missense_Mutation_p.R173P	NM_001256409.1	NP_001243338.1	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	173										breast(2)|kidney(1)|large_intestine(1)|lung(5)	9						AAGTCTTTCCGGGAGCTGACC	0.473000													20	59					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161010584	161010584	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:161010584C>A	ENST00000447678.1	-	25	4068		c.e25+1		LPA_ENST00000316300.5_Splice_Site	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAAAGACATACCCATTTGGGT	0.458000													35	48					6.00712e-18	9.22483e-18	1	1	0
RYR2	6262	broad.mit.edu	37	1	237897042	237897042	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:237897042G>T	ENST00000366574.2	+	79	11394	c.11077G>T	c.(11077-11079)Gat>Tat	p.D3693Y	RYR2_ENST00000360064.6_Missense_Mutation_p.D3691Y|RYR2_ENST00000542537.1_Missense_Mutation_p.D3677Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3693					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCCTATGCAGATATTATGGC	0.348000													10	64					0.0931896	0.0951145	1	1	0
BCL11B	64919	broad.mit.edu	37	14	99641428	99641428	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:99641428C>A	ENST00000345514.2	-	3	1798	c.1532G>T	c.(1531-1533)gGc>gTc	p.G511V	BCL11B_ENST00000357195.3_Missense_Mutation_p.G582V|BCL11B_ENST00000443726.2_Missense_Mutation_p.G388V	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	582						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CTTggccgcgccgccccccgc	0.731000			T	TLX3	T-ALL								16	10					3.52763e-06	4.0481e-06	1	1	0
DCSTAMP	81501	broad.mit.edu	37	8	105367346	105367346	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:105367346T>G	ENST00000297581.2	+	3	1320	c.1271T>G	c.(1270-1272)cTg>cGg	p.L424R	DCSTAMP_ENST00000520080.1_3'UTR|DCSTAMP_ENST00000517991.1_Intron|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	424					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											CATGCAAAGCTGCTTAAAAAA	0.463000													20	215					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96354701	96354701	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:96354701G>T	ENST00000324765.8	+	20	2603	c.2256G>T	c.(2254-2256)gtG>gtT	p.V752V	DIAPH2_ENST00000355827.4_Silent_p.V752V|DIAPH2_ENST00000373049.4_Silent_p.V752V|DIAPH2_ENST00000373061.3_Silent_p.V752V|DIAPH2_ENST00000373054.4_Silent_p.V748V			O60879	DIAP2_HUMAN	diaphanous-related formin 2	752	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						AGAACCTTGTGAAACATCTTC	0.313000													14	23					4.3838e-07	5.12868e-07	1	1	0
MLIP	90523	broad.mit.edu	37	6	53883830	53883830	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:53883830G>C	ENST00000514921.1	+	1	117	c.4G>C	c.(4-6)Gaa>Caa	p.E2Q	MLIP_ENST00000509997.1_Missense_Mutation_p.E2Q|MLIP_ENST00000370877.2_Missense_Mutation_p.E2Q|MLIP_ENST00000274897.5_Missense_Mutation_p.E2Q			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	2	Interaction with LMNA.					nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						TTTCAATATGGAACTTGAAAA	0.343000													4	37					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171520	68171520	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:68171520G>T	ENST00000243457.3	+	2	723	c.340G>T	c.(340-342)Gat>Tat	p.D114Y	KCNJ2_ENST00000535240.1_Missense_Mutation_p.D114Y	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	114					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					TGGGGACCTGGATGCATCCAA	0.522000													38	124					1.36161e-19	2.14588e-19	1	1	0
RHCE	6006	broad.mit.edu	37	1	25717280	25717280	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:25717280G>T	ENST00000349320.3	-	7	1101	c.713C>A	c.(712-714)tCa>tAa	p.S238*	RHCE_ENST00000340849.4_Intron|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000413854.1_Nonsense_Mutation_p.S254*|RHCE_ENST00000455194.1_Intron|RHCE_ENST00000243186.6_Nonsense_Mutation_p.S254*|RHCE_ENST00000425135.1_Nonsense_Mutation_p.S254*|RHCE_ENST00000374352.2_Nonsense_Mutation_p.S238*|RHCE_ENST00000349438.4_Nonsense_Mutation_p.S254*|RHCE_ENST00000294413.7_Nonsense_Mutation_p.S254*			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	254			M -> V (in RhEFM).			integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGACCCTGAGATGGCTGT	0.517000													44	118					1.15183e-24	1.97457e-24	1	1	0
MYH10	4628	broad.mit.edu	37	17	8480657	8480657	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:8480657C>A	ENST00000360416.3	-	5	669		c.e5-1		MYH10_ENST00000379980.4_Splice_Site|MYH10_ENST00000269243.4_Splice_Site|MYH10_ENST00000396239.1_Splice_Site	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle						actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TGACTCACCCCTGAAAGAAAG	0.343000													50	38					1.19451e-25	2.08605e-25	1	1	0
AFF4	27125	broad.mit.edu	37	5	132232265	132232265	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:132232265C>G	ENST00000265343.5	-	11	2436	c.2057G>C	c.(2056-2058)aGc>aCc	p.S686T	AFF4_ENST00000378595.3_Missense_Mutation_p.S686T	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	686					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCGAAAAAAGCTATCTTCTTC	0.468000													25	62					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4169604	4169604	+	Missense_Mutation	SNP	C	C	G	rs140791078		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:4169604C>G	ENST00000404826.2	+	27	4143	c.4004C>G	c.(4003-4005)aCg>aGg	p.T1335R	SDK1_ENST00000389531.3_Missense_Mutation_p.T1335R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1335	Fibronectin type-III 7.				cell adhesion	integral to membrane		p.T1335M(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGGAACCACACGCAGTCGGCC	0.652000													18	68					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19713829	19713829	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:19713829C>A	ENST00000284885.3	-	13	1498	c.1465G>T	c.(1465-1467)Gat>Tat	p.D489Y		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	489	MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						AACGCAATATCACTCAGGATC	0.393000													42	97					5.44703e-19	8.55234e-19	1	1	0
FLI1	2313	broad.mit.edu	37	11	128677124	128677124	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:128677124G>T	ENST00000344954.6	+	7	1060	c.672G>T	c.(670-672)cgG>cgT	p.R224R	FLI1_ENST00000525560.1_Silent_p.R64R|FLI1_ENST00000281428.8_Silent_p.R191R|FLI1_ENST00000429175.2_Silent_p.R257R|FLI1_ENST00000534087.1_Silent_p.R224R			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	257					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CAGAGCAACGGCCCCAGCCAG	0.512000			T	EWSR1	Ewing sarcoma								3	7					0.150653	0.152837	1	1	0
RASGRF2	5924	broad.mit.edu	37	5	80369232	80369232	+	Missense_Mutation	SNP	C	C	A	rs140574397		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:80369232C>A	ENST00000265080.4	+	5	915	c.848C>A	c.(847-849)cCc>cAc	p.P283H	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	283	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AAGAAGCCCCCCATCAGCCAC	0.488000													16	60					2.32078e-09	2.89667e-09	1	1	0
PCDHA5	56143	broad.mit.edu	37	5	140202957	140202957	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:140202957C>A	ENST00000529859.1	+	1	1597	c.1597C>A	c.(1597-1599)Cag>Aag	p.Q533K	PCDHA5_ENST00000378126.3_Missense_Mutation_p.Q533K|PCDHA5_ENST00000529619.1_Missense_Mutation_p.Q533K|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCAGTTCCAGGTGAGCGC	0.687000													50	126					5.13769e-22	8.39622e-22	1	1	0
OR6K2	81448	broad.mit.edu	37	1	158670283	158670283	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:158670283G>C	ENST00000359610.2	-	1	203	c.160C>G	c.(160-162)Cac>Gac	p.H54D		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					GTGTGGAGGTGAGTATTCAAC	0.443000													54	67					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184040239	184040239	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:184040239G>C	ENST00000342981.4	+	10	2022		c.e10+1		EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000434061.2_Splice_Site|EIF4G1_ENST00000411531.1_Splice_Site|EIF4G1_ENST00000382330.3_Splice_Site|EIF4G1_ENST00000346169.2_Splice_Site|EIF4G1_ENST00000427845.1_Splice_Site|EIF4G1_ENST00000424196.1_Splice_Site|EIF4G1_ENST00000319274.6_Splice_Site|EIF4G1_ENST00000441154.1_Splice_Site|EIF4G1_ENST00000392537.2_Splice_Site|EIF4G1_ENST00000352767.3_Splice_Site|EIF4G1_ENST00000350481.5_Splice_Site|EIF4G1_ENST00000414031.1_Splice_Site|EIF4G1_ENST00000435046.2_Splice_Site	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1						insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTTCAAGGAGGTAAGGGAGCA	0.473000													22	26					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141128284	141128284	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:141128284T>A	ENST00000389484.3	-	71	11974	c.11003A>T	c.(11002-11004)gAa>gTa	p.E3668V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3668	LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTACCTCTTTCACAGTTCTC	0.408000										TSP Lung(27;0.18)			117	182					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177690215	177690215	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:177690215G>T	ENST00000390654.3	-	9	990	c.633C>A	c.(631-633)ggC>ggA	p.G211G	COL23A1_ENST00000407622.1_Silent_p.G175G	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	211	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		TTACCGCTGGGCCTTGTGCTC	0.652000													13	61					2.32078e-09	2.89667e-09	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617551	77617551	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:77617551G>T	ENST00000521891.2	+	2	1676	c.1228G>T	c.(1228-1230)Ggg>Tgg	p.G410W	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G410W|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G410W|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G410W	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	410						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAATCTGGGGGGGCTGTCTAG	0.527000										HNSCC(33;0.089)			5	83					0.0215528	0.0220784	1	1	0
LATS2	26524	broad.mit.edu	37	13	21557821	21557821	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:21557821C>A	ENST00000382592.4	-	5	2429	c.2024G>T	c.(2023-2025)gGg>gTg	p.G675V	LATS2_ENST00000542899.1_Missense_Mutation_p.G675V	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	675	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GGCACCGATCCCCAGGGTTTT	0.483000													22	63					2.89027e-11	3.78756e-11	1	1	0
ABCD2	225	broad.mit.edu	37	12	40013511	40013511	+	Translation_Start_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:40013511G>T	ENST00000308666.3	-	0	42					NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2						fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						AAGTCCTACAGCGTCCCATAG	0.448000													3	12					0.115264	0.117218	1	1	0
PTGDS	5730	broad.mit.edu	37	9	139874452	139874452	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:139874452C>T	ENST00000224167.2	+	4	563	c.488C>T	c.(487-489)gCg>gTg	p.A163V	PTGDS_ENST00000371625.3_Missense_Mutation_p.A129V			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	129					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GACCAGTACGCGCTGCTGTAC	0.657000													12	164					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528210	157528210	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:157528210A>T	ENST00000346085.5	+	20	5936	c.5935A>T	c.(5935-5937)Att>Ttt	p.I1979F	ARID1B_ENST00000367148.1_Missense_Mutation_p.I2019F|ARID1B_ENST00000350026.5_Missense_Mutation_p.I1966F|ARID1B_ENST00000275248.4_Missense_Mutation_p.I1961F	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1966					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GGGGAAGCTGATTCTTCTTCA	0.527000													58	55					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108547965	108547965	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:108547965G>T	ENST00000526794.1	+	4	564	c.532G>T	c.(532-534)Gga>Tga	p.G178*	DDX10_ENST00000322536.3_Nonsense_Mutation_p.G178*			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	178	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		CATCATTGGTGGAAAGGTTTG	0.448000			T	NUP98	AML*								76	129					1.15773e-35	2.2052e-35	1	1	0
POPDC2	64091	broad.mit.edu	37	3	119367340	119367340	+	Missense_Mutation	SNP	C	C	A	rs143200336		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:119367340C>A	ENST00000493094.1	-	3	1235	c.776G>T	c.(775-777)cGc>cTc	p.R259L	POPDC2_ENST00000264231.3_Missense_Mutation_p.R259L|POPDC2_ENST00000538678.1_Missense_Mutation_p.R259L|POPDC2_ENST00000474523.1_5'UTR|POPDC2_ENST00000468801.1_Missense_Mutation_p.R259L			Q9HBU9	POPD2_HUMAN	popeye domain containing 2	259						integral to membrane				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	13				GBM - Glioblastoma multiforme(114;0.242)		GATGTCAAAGCGCAGCCCAAA	0.542000													34	79					1.66425e-11	2.20153e-11	1	1	0
CDH11	1009	broad.mit.edu	37	16	64981904	64981904	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:64981904C>A	ENST00000268603.4	-	13	2608	c.1993G>T	c.(1993-1995)Gat>Tat	p.D665Y	CDH11_ENST00000394156.3_3'UTR|CDH11_ENST00000566827.1_Missense_Mutation_p.D539Y	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	665					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCCCCTTCATCATCATAAGTA	0.433000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			37	89					3.2961e-07	3.89412e-07	1	1	0
POLR3A	11128	broad.mit.edu	37	10	79753002	79753002	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:79753002C>T	ENST00000372371.3	-	20	2877	c.2740G>A	c.(2740-2742)Gga>Aga	p.G914R		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	914					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TCATCTTTTCCCTCCATAGCT	0.398000													107	87					0	0	1	0	0
PPP1CB	5500	broad.mit.edu	37	2	29011673	29011673	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:29011673C>G	ENST00000395366.2	+	6	1014	c.742C>G	c.(742-744)Cag>Gag	p.Q248E	SPDYA_ENST00000462832.1_3'UTR|PPP1CB_ENST00000296122.6_Missense_Mutation_p.Q248E|PPP1CB_ENST00000358506.2_Missense_Mutation_p.Q248E	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	248					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding	p.Q248E(1)		cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					TCGAGCTCATCAGGTATGAAA	0.398000													9	59					0	0	1	0	0
NECAB1	64168	broad.mit.edu	37	8	91962042	91962042	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:91962042A>T	ENST00000417640.2	+	11	1205	c.868A>T	c.(868-870)Ata>Tta	p.I290L	NECAB1_ENST00000522820.1_Missense_Mutation_p.I39L|NECAB1_ENST00000521366.1_Missense_Mutation_p.I39L	NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	290	ABM.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CAGTATTTCTATACAGAAGCT	0.323000													7	32					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131219733	131219733	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:131219733T>A	ENST00000298542.4	-	7	696	c.521A>T	c.(520-522)gAc>gTc	p.D174V	FRMD7_ENST00000370879.1_Missense_Mutation_p.D54V|FRMD7_ENST00000464296.1_Missense_Mutation_p.D159V	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	174	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					TAGCAGAATGTCAGATTCAGC	0.498000													27	77					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012808	153012808	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:153012808C>A	ENST00000368757.1	-	2	295	c.15G>T	c.(13-15)caG>caT	p.Q5H	SPRR2D_ENST00000368758.3_Missense_Mutation_p.Q5H|SPRR2D_ENST00000360379.3_Missense_Mutation_p.Q5H|SPRR2D_ENST00000368756.1_Missense_Mutation_p.Q5H			P22532	SPR2D_HUMAN	small proline-rich protein 2D	5					keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCACTGCTGCTGTTGATAAG	0.557000													40	109					9.84934e-19	1.53496e-18	1	1	0
OR52N4	390072	broad.mit.edu	37	11	5776439	5776439	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:5776439C>A	ENST00000317254.3	+	1	517	c.469C>A	c.(469-471)Ctc>Atc	p.L157I	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		AGGGGTATTACTCATTATTCC	0.478000													34	99					8.53417e-09	1.04653e-08	1	1	0
NRXN3	9369	broad.mit.edu	37	14	80164008	80164008	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:80164008A>G	ENST00000281127.7	+	4	1516	c.637A>G	c.(637-639)Ata>Gta	p.I213V	NRXN3_ENST00000335750.5_Missense_Mutation_p.I845V|NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000557594.1_Missense_Mutation_p.I213V|RP11-242P2.1_ENST00000553322.1_RNA|NRXN3_ENST00000554719.1_Missense_Mutation_p.I845V|NRXN3_ENST00000428277.2_Missense_Mutation_p.I243V	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	213	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCAGGCGCAAATAGCCATTGG	0.473000													31	24					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	231830369	231830369	+	Translation_Start_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:231830369C>A	ENST00000366637.3	+	0	918				DISC1_ENST00000539444.1_Missense_Mutation_p.R289S|DISC1_ENST00000602281.1_Missense_Mutation_p.R289S|DISC1_ENST00000537876.1_Missense_Mutation_p.R289S|DISC1_ENST00000366633.3_Missense_Mutation_p.R289S|DISC1_ENST00000535983.1_Missense_Mutation_p.R289S|DISC1_ENST00000439617.2_Missense_Mutation_p.R289S|DISC1_ENST00000366636.4_Missense_Mutation_p.R289S|DISC1_ENST00000602873.1_Intron|DISC1_ENST00000317586.4_Missense_Mutation_p.R289S|TRAX_ENST00000602962.1_3'UTR	NM_001012957.1	NP_001012975.1	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1						microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				CAGGCCAGAGCGTGACATGCA	0.612000													29	59					5.45727e-16	8.05643e-16	1	1	0
TRBV6-9	28598	broad.mit.edu	37	7	142104539	142104539	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142104539G>T	ENST00000390379.1	-	0	14																											CACAGCACAGGAGCCCGATGC	0.607000													26	62					4.47668e-21	7.21768e-21	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70974916	70974916	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:70974916G>C	ENST00000334414.6	-	10	2522	c.2478C>G	c.(2476-2478)taC>taG	p.Y826*	PTPRB_ENST00000261266.5_Nonsense_Mutation_p.Y608*|PTPRB_ENST00000551525.1_Nonsense_Mutation_p.Y825*|PTPRB_ENST00000550358.1_Nonsense_Mutation_p.Y826*|PTPRB_ENST00000538708.1_Nonsense_Mutation_p.Y608*|PTPRB_ENST00000451516.2_Nonsense_Mutation_p.Y518*|PTPRB_ENST00000550857.1_Nonsense_Mutation_p.Y518*	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	608	Fibronectin type-III 10.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGTGGAAGCTGTATCTGCTGG	0.488000													36	143					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87437524	87437524	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:87437524G>T	ENST00000517970.1	+	10	1441	c.1134G>T	c.(1132-1134)gaG>gaT	p.E378D	WWP1_ENST00000265428.4_Missense_Mutation_p.E378D|WWP1_ENST00000349423.2_Missense_Mutation_p.E160D|WWP1_ENST00000341922.2_Missense_Mutation_p.E248D	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	378	WW 1.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						CCACATGGGAGAGACCACAAC	0.323000													17	183					5.01169e-05	5.55386e-05	1	1	0
ABCB5	340273	broad.mit.edu	37	7	20682814	20682814	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:20682814C>G	ENST00000404938.2	+	6	974	c.322C>G	c.(322-324)Ctg>Gtg	p.L108V		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	292	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CAGGTTGACCCTGTATTATGT	0.363000													4	21					0	0	1	0	0
SLC13A2	9058	broad.mit.edu	37	17	26818829	26818829	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:26818829G>T	ENST00000444914.3	+	6	1404	c.984G>T	c.(982-984)ctG>ctT	p.L328L	SLC13A2_ENST00000545060.1_Silent_p.L236L|SLC13A2_ENST00000537681.1_Silent_p.L208L|SLC13A2_ENST00000314669.5_Silent_p.L279L	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	279						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	TCTTGCTGCTGCTGGCCTGGT	0.587000													17	55					5.3912e-06	6.11975e-06	1	1	0
GABRB3	2562	broad.mit.edu	37	15	26806203	26806203	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:26806203A>T	ENST00000541819.2	-	9	1226	c.1124T>A	c.(1123-1125)cTg>cAg	p.L375Q	GABRB3_ENST00000545868.1_Missense_Mutation_p.L234Q|GABRB3_ENST00000311550.5_Missense_Mutation_p.L319Q|GABRB3_ENST00000400188.3_Missense_Mutation_p.L248Q|GABRB3_ENST00000299267.4_Missense_Mutation_p.L319Q			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	319					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGAAGGGCCAGGAACACAAA	0.478000													29	67					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159830426	159830426	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:159830426T>C	ENST00000297151.4	-	16	2014	c.1627A>G	c.(1627-1629)Atg>Gtg	p.M543V		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	543					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAATCTGCATGGTCTCCTTG	0.453000													101	240					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62933635	62933635	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:62933635G>A	ENST00000306494.6	-	7	1165	c.1166C>T	c.(1165-1167)aCc>aTc	p.T389I	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	389					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GGCCAGGAGGGTGACTGCACC	0.512000													14	80					0	0	1	0	0
TMEM41A	90407	broad.mit.edu	37	3	185212434	185212434	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:185212434T>A	ENST00000421852.1	-	4	646	c.551A>T	c.(550-552)cAg>cTg	p.Q184L	TMEM41A_ENST00000475480.1_5'UTR|TMEM41A_ENST00000296254.3_Intron	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	184						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAAGAAGAACTGCACGATGGG	0.468000													82	207					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49229929	49229929	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:49229929T>C	ENST00000308025.3	-	11	1436	c.1357A>G	c.(1357-1359)Atc>Gtc	p.I453V		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	453	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						AGTGTGGTGATCCAGACCAGC	0.507000													41	222					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27765270	27765270	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:27765270G>C	ENST00000333743.6	+	7	1119	c.865_splice	c.e7+1	p.G289_splice	RP11-100M12.3_ENST00000556642.1_RNA	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	289					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AACAGCATTAGGTGAGTTTCA	0.338000													10	14					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43590049	43590049	+	Silent	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:43590049G>C	ENST00000395891.1	+	27	4859	c.4254G>C	c.(4252-4254)acG>acC	p.T1418T	HECW1_ENST00000453890.1_Silent_p.T1384T	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1418	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ACAAGGTCACGGAAAGGGAGT	0.507000													10	25					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123476314	123476314	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:123476314C>A	ENST00000280562.5	-	16	2741	c.2536G>T	c.(2536-2538)Ggc>Tgc	p.G846C	PITPNM2_ENST00000542749.1_Intron|PITPNM2_ENST00000320201.4_Intron|PITPNM2_ENST00000392428.1_Intron			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	812	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TCGGCACAGCCCGGGCGGGGC	0.692000													14	9					3.52763e-06	4.0481e-06	1	1	0
ZNF777	27153	broad.mit.edu	37	7	149129869	149129869	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:149129869C>A	ENST00000247930.4	-	6	1817	c.1494G>T	c.(1492-1494)gaG>gaT	p.E498D		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCTCCTCGCCCTCGGGGGACA	0.677000													4	33					0.00116845	0.0012377	1	1	0
EVC2	132884	broad.mit.edu	37	4	5624282	5624282	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:5624282C>G	ENST00000310917.2	-	14	2974	c.2243G>C	c.(2242-2244)tGg>tCg	p.W748S	EVC2_ENST00000344938.1_Missense_Mutation_p.W828S|EVC2_ENST00000344408.5_Missense_Mutation_p.W828S	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	828						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CAGGTGCTCCCAGCGTCGCAG	0.617000													6	28					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27222623	27222623	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:27222623T>C	ENST00000230582.3	+	10	1317	c.1302T>C	c.(1300-1302)ccT>ccC	p.P434P	PRSS16_ENST00000377456.2_Intron|PRSS16_ENST00000421826.2_Silent_p.P177P	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	434					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GCCAGACCCCTGGGGCTAACA	0.557000													24	125					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121435856	121435856	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:121435856G>A	ENST00000393667.3	-	9	1126	c.1016C>T	c.(1015-1017)tCc>tTc	p.S339F	GOLGB1_ENST00000340645.5_Missense_Mutation_p.S334F	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	334					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ATTATGGAAGGATAATTTTCT	0.433000													52	109					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67132165	67132165	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:67132165C>A	ENST00000590645.1	-	4	716	c.528G>T	c.(526-528)ttG>ttT	p.L176F	ABCA6_ENST00000284425.2_Intron			Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	0					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTCTGTTGCCCAACCTCCTCT	0.368000													5	16					1.23904e-05	1.39704e-05	1	1	0
ZBTB41	360023	broad.mit.edu	37	1	197168763	197168763	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:197168763T>A	ENST00000367405.4	-	1	909	c.841A>T	c.(841-843)Aat>Tat	p.N281Y	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						TTTTCTTGATTCAAATTGTCT	0.403000													40	106					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75898352	75898352	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:75898352G>T	ENST00000262207.4	+	2	598	c.130G>T	c.(130-132)Ggt>Tgt	p.G44C	CRISPLD1_ENST00000519798.1_3'UTR	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	44						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GGATGAGGATGGTGAGTGGTG	0.433000													87	180					4.41824e-40	8.55143e-40	1	1	0
DNAH3	55567	broad.mit.edu	37	16	20986734	20986734	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:20986734C>T	ENST00000261383.3	-	51	8079	c.8080G>A	c.(8080-8082)Gcg>Acg	p.A2694T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2694	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGCATAACCGCTACCTAGCAA	0.458000													64	50					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980455	110980455	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:110980455G>T	ENST00000524391.1	-	4	2397	c.1365C>A	c.(1363-1365)acC>acA	p.T455T	KCNV1_ENST00000297404.1_Silent_p.T455T			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	455						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CTATATTCTTGGTAAGCTTCT	0.438000													24	156					1.85244e-09	2.32246e-09	1	1	0
MAGEB16	139604	broad.mit.edu	37	X	35820799	35820799	+	Silent	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:35820799A>T	ENST00000399989.1	+	2	765	c.486A>T	c.(484-486)ctA>ctT	p.L162L	MAGEB16_ENST00000399985.1_Silent_p.L162L|MAGEB16_ENST00000399992.1_Silent_p.L194L|MAGEB16_ENST00000399988.1_Silent_p.L162L|MAGEB16_ENST00000399987.1_Silent_p.L162L	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	162	MAGE.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						CTGAGCACCTAGAGATGATAT	0.468000													23	60					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147020382	147020382	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:147020382G>T	ENST00000265272.5	-	9	1753	c.1286C>A	c.(1285-1287)cCt>cAt	p.P429H	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.P429H|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.P387H	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	429						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCAAAACAGGCCTCTAAAT	0.413000													16	108					4.35082e-09	5.36665e-09	1	1	0
KCNJ16	3773	broad.mit.edu	37	17	68128529	68128529	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:68128529G>C	ENST00000585558.1	+	4	794	c.406G>C	c.(406-408)Gat>Cat	p.D136H	KCNJ16_ENST00000586462.1_Missense_Mutation_p.D140H|KCNJ16_ENST00000589377.1_Missense_Mutation_p.D101H|KCNJ16_ENST00000283936.1_Missense_Mutation_p.D101H|KCNJ16_ENST00000392671.1_Missense_Mutation_p.D101H|KCNJ16_ENST00000392670.1_Missense_Mutation_p.D101H			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	101					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					TCATCATGGCGATCTATTAAA	0.418000													25	76					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112391	248112391	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248112391C>A	ENST00000357191.3	+	1	232	c.232C>A	c.(232-234)Cct>Act	p.P78T	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CACCATTGTTCCTAAGATGGC	0.448000													120	598					9.16818e-52	1.82928e-51	1	1	0
MYH7B	57644	broad.mit.edu	37	20	33588185	33588185	+	Missense_Mutation	SNP	A	A	T	rs61746253	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:33588185A>T	ENST00000262873.7	+	37	5089	c.4997A>T	c.(4996-4998)aAg>aTg	p.K1666M		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1624						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTCAAGAAGAAGATGGAGGGT	0.662000													6	118					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32459413	32459413	+	Missense_Mutation	SNP	G	G	T	rs151150099		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:32459413G>T	ENST00000357033.4	-	28	4011	c.3805C>A	c.(3805-3807)Cat>Aat	p.H1269N	DMD_ENST00000378677.2_Missense_Mutation_p.H1265N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1269					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AATAACTCATGCCAACATGCC	0.313000													27	94					3.73988e-18	5.76422e-18	1	1	0
ARHGEF2	9181	broad.mit.edu	37	1	155922485	155922485	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:155922485G>C	ENST00000368316.1	-	19	2304	c.1834C>G	c.(1834-1836)Ctt>Gtt	p.L612V	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.L640V|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.L639V|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.L641V|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.L612V			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	640					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAGCGGAAAAGGCCCCTGGGC	0.642000													35	60					0	0	1	0	0
MIR519B	574469	broad.mit.edu	37	19	54198475	54198475	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:54198475G>T	ENST00000385090.1	+	0	9					NR_030191.1																						CCCATGCTGTGACCCTCTAGA	0.403000													99	66					4.09449e-47	8.1309e-47	1	1	0
NR1I3	9970	broad.mit.edu	37	1	161200595	161200595	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:161200595C>T	ENST00000506209.1	-	7	980	c.838G>A	c.(838-840)Ggg>Agg	p.G280R	NR1I3_ENST00000367981.3_Intron|NR1I3_ENST00000508387.1_Intron|NR1I3_ENST00000479324.1_Intron|NR1I3_ENST00000502985.1_Intron|NR1I3_ENST00000367984.4_Intron|NR1I3_ENST00000367985.3_Intron|NR1I3_ENST00000367982.4_Intron|NR1I3_ENST00000428574.2_Intron|NR1I3_ENST00000504010.1_Intron|NR1I3_ENST00000412844.2_Intron|NR1I3_ENST00000367980.2_Intron|NR1I3_ENST00000437437.2_Intron|NR1I3_ENST00000515621.1_Intron|NR1I3_ENST00000512372.1_Intron|NR1I3_ENST00000511944.1_Intron|NR1I3_ENST00000511676.1_Intron|NR1I3_ENST00000511748.1_Intron|NR1I3_ENST00000508740.1_Intron|NR1I3_ENST00000367979.2_Intron|NR1I3_ENST00000367983.4_Intron|NR1I3_ENST00000442691.2_Intron|NR1I3_ENST00000505005.1_Intron			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CTCAGTGTCCCACCGTACCGA	0.537000													32	33					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36669321	36669321	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:36669321C>T	ENST00000543751.1	+	14	1472	c.1327C>T	c.(1327-1329)Ctg>Ttg	p.L443L	MELK_ENST00000536987.1_Silent_p.L344L|MELK_ENST00000545008.1_Silent_p.L404L|MELK_ENST00000538311.1_Silent_p.L281L|MELK_ENST00000298048.2_Silent_p.L475L|MELK_ENST00000541717.1_Silent_p.L434L|MELK_ENST00000536329.1_Silent_p.L404L|MELK_ENST00000536860.1_Silent_p.L427L	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	475						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			AAACCAGTGCCTGAAAGAAAC	0.353000													40	63					0	0	1	0	0
SHISA2	387914	broad.mit.edu	37	13	26621047	26621047	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:26621047G>T	ENST00000319420.3	-	2	547	c.492C>A	c.(490-492)atC>atA	p.I164I		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	164					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						GGATCATGGGGATGGTCTCCA	0.677000													23	31					1.50039e-11	1.9879e-11	1	1	0
GMIP	51291	broad.mit.edu	37	19	19740856	19740856	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:19740856T>C	ENST00000203556.4	-	21	2966	c.2829A>G	c.(2827-2829)ctA>ctG	p.L943L	GMIP_ENST00000587238.1_Silent_p.L917L|GMIP_ENST00000445806.2_Silent_p.L914L	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	943					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ATTTCGAGAGTAGCCGGGCTG	0.677000													8	9					0	0	1	0	0
PFN4	375189	broad.mit.edu	37	2	24345376	24345376	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:24345376G>A	ENST00000313213.4	-	2	401	c.30C>T	c.(28-30)gaC>gaT	p.D10D	PFN4_ENST00000465360.1_Intron	NM_199346.1	NP_955378.1	Q8NHR9	PROF4_HUMAN	profilin family, member 4	10					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			breast(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAGAGGGTGTCTAACAATA	0.458000													89	48					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670581	49670581	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:49670581C>T	ENST00000561648.1	-	4	2535	c.2482G>A	c.(2482-2484)Gag>Aag	p.E828K	ZNF423_ENST00000562520.1_Missense_Mutation_p.E768K|ZNF423_ENST00000535559.1_Missense_Mutation_p.E711K|ZNF423_ENST00000562871.1_Missense_Mutation_p.E768K|ZNF423_ENST00000563137.2_Missense_Mutation_p.E768K|ZNF423_ENST00000567169.1_Missense_Mutation_p.E711K|ZNF423_ENST00000262383.2_Missense_Mutation_p.E828K	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	828					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CAGTGCTTCTCCCGCAGGTGC	0.572000													6	45					0	0	1	0	0
TRAJ41	28714	broad.mit.edu	37	14	22966687	22966687	+	RNA	SNP	G	G	A	rs145922690	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:22966687G>A	ENST00000390496.1	+	0	46																											AAGGCACCTCGCTGTTGGTCA	0.463000													31	15					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532696	92532696	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:92532696G>C	ENST00000298047.6	+	9	6534	c.6517G>C	c.(6517-6519)Gag>Cag	p.E2173Q	FAT3_ENST00000525166.1_Missense_Mutation_p.E2023Q|FAT3_ENST00000409404.2_Missense_Mutation_p.E2173Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2173	Cadherin 19.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TACATCTGTGGAGCTTCCCAT	0.418000										TCGA Ovarian(4;0.039)			8	57					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248814083	248814083	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248814083A>T	ENST00000344889.3	-	1	102	c.103T>A	c.(103-105)Ttt>Att	p.F35I		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAGGTCAAAAAGACCAGGAGA	0.527000													9	97					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767855	77767855	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:77767855G>C	ENST00000521891.2	+	10	9146	c.8698G>C	c.(8698-8700)Gaa>Caa	p.E2900Q	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2855Q|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2855Q|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2874Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2855						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGACCGCAGCGAAACGTCCAG	0.512000										HNSCC(33;0.089)			15	90					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633488	116633488	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:116633488C>A	ENST00000260210.4	-	4	840	c.817G>T	c.(817-819)Gat>Tat	p.D273Y	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	273										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGAGCCAAATCAGGGGAGTCA	0.517000													185	86					2.03118e-68	4.10142e-68	1	1	0
CLEC10A	10462	broad.mit.edu	37	17	6979160	6979160	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:6979160G>T	ENST00000576617.1	-	7	753	c.484C>A	c.(484-486)Caa>Aaa	p.Q162K	CLEC10A_ENST00000254868.4_Missense_Mutation_p.Q189K|CLEC10A_ENST00000571664.1_Missense_Mutation_p.Q165K|CLEC10A_ENST00000416562.2_Missense_Mutation_p.Q162K			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	189					endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						CAGCTGTCTTGGTGCTCCACC	0.592000													39	37					7.63091e-17	1.15287e-16	1	1	0
NEB	4703	broad.mit.edu	37	2	152507232	152507232	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:152507232C>A	ENST00000427231.2	-	53	7285	c.7083G>T	c.(7081-7083)gtG>gtT	p.V2361V	NEB_ENST00000172853.10_Silent_p.V2361V|NEB_ENST00000397345.3_Silent_p.V2361V|NEB_ENST00000409198.1_Silent_p.V2361V|NEB_ENST00000603639.1_Silent_p.V2361V|NEB_ENST00000604864.1_Silent_p.V2361V	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2361					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCAACATGTCCACTGGGCTGG	0.458000													319	168					2.56761e-168	5.26046e-168	1	1	0
PLSCR5	389158	broad.mit.edu	37	3	146307519	146307519	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:146307519G>T	ENST00000443512.1	-	6	1701	c.698C>A	c.(697-699)gCt>gAt	p.A233D	PLSCR5_ENST00000492200.1_Missense_Mutation_p.A233D|PLSCR5-AS1_ENST00000473817.1_RNA|PLSCR5_ENST00000482567.1_Missense_Mutation_p.A221D	NM_001085420.1	NP_001078889.1	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	233										endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						GAAATTGTCAGCATTTGTGAA	0.368000													56	83					1.67886e-27	2.99414e-27	1	1	0
ANO4	121601	broad.mit.edu	37	12	101490387	101490387	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:101490387G>T	ENST00000392979.3	+	18	2068	c.1707G>T	c.(1705-1707)ctG>ctT	p.L569L	ANO4_ENST00000550015.1_Silent_p.L124L|ANO4_ENST00000392977.3_Silent_p.L604L|ANO4_ENST00000299222.9_Silent_p.L124L	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	604						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTGTCAATCTGAACAGCTCCA	0.483000										HNSCC(74;0.22)			21	69					7.41877e-09	9.11077e-09	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100515177	100515177	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:100515177A>T	ENST00000395996.1	+	27	4267	c.4157_splice	c.e27+1	p.R1386_splice	VPS13B_ENST00000358544.2_Splice_Site_p.S1386_splice|VPS13B_ENST00000357162.2_Splice_Site_p.R1386_splice			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1386					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTATAGAAGCAGGTAAATAAT	0.279000													35	285					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161725	220161725	+	Missense_Mutation	SNP	G	G	T	rs35614511		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:220161725G>T	ENST00000295718.2	-	15	2458	c.2218C>A	c.(2218-2220)Cat>Aat	p.H740N	PTPRN_ENST00000409251.3_Missense_Mutation_p.H711N|PTPRN_ENST00000423636.2_Missense_Mutation_p.H650N	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	740	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AAGTCAGGATGCCGGTTCTTT	0.637000													66	42					2.17656e-39	4.203e-39	1	1	0
OR5T3	390154	broad.mit.edu	37	11	56020579	56020579	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56020579A>T	ENST00000303059.3	+	1	904	c.904A>T	c.(904-906)Atc>Ttc	p.I302F		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					AGACCATGACATCATAGTGTC	0.373000													25	122					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36438782	36438782	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:36438782G>T	ENST00000265748.2	+	3	488	c.267G>T	c.(265-267)gaG>gaT	p.E89D	ANLN_ENST00000396068.2_Missense_Mutation_p.E89D	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	89	Interaction with CD2AP.|Nuclear localization.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AACCAGTTGAGTCGACATCTG	0.433000													19	79					8.34094e-07	9.70414e-07	1	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590113	140590113	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:140590113C>A	ENST00000239450.2	+	1	1823	c.1634C>A	c.(1633-1635)gCg>gAg	p.A545E	PCDHB12_ENST00000541609.1_Missense_Mutation_p.A208E	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		545	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCAGCGAGGCGCTGGTGCGC	0.692000													30	81					1.39806e-14	1.99383e-14	1	1	0
PARD3B	117583	broad.mit.edu	37	2	206023588	206023588	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:206023588G>T	ENST00000406610.2	+	11	1784	c.1577G>T	c.(1576-1578)gGg>gTg	p.G526V	PARD3B_ENST00000462231.1_Missense_Mutation_p.G526V|PARD3B_ENST00000351153.1_Missense_Mutation_p.G526V|PARD3B_ENST00000349953.3_Missense_Mutation_p.G526V|PARD3B_ENST00000358768.2_Intron	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	526	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ACAGACTTGGGGATTTTTATC	0.463000													81	35					2.3666e-43	4.6124e-43	1	1	0
ZNF716	441234	broad.mit.edu	37	7	57529241	57529241	+	Silent	SNP	G	G	T	rs142521234	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:57529241G>T	ENST00000420713.1	+	4	1186	c.1074G>T	c.(1072-1074)ggG>ggT	p.G358G		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AAGAATGTGGGAAAGCCTTTA	0.398000													16	29					6.72482e-11	8.75791e-11	1	1	0
PTPRN2	5799	broad.mit.edu	37	7	157926564	157926564	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:157926564T>A	ENST00000389413.3	-	9	1464	c.1361A>T	c.(1360-1362)aAa>aTa	p.K454I	PTPRN2_ENST00000404321.2_Missense_Mutation_p.K477I|PTPRN2_ENST00000409483.1_Missense_Mutation_p.K416I|PTPRN2_ENST00000389416.4_Missense_Mutation_p.K437I|PTPRN2_ENST00000389418.4_Missense_Mutation_p.K454I	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	454						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CAGCAGATCTTTGGAATACGT	0.602000													47	102					0	0	1	0	0
RTFDC1	51507	broad.mit.edu	37	20	55088422	55088422	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:55088422G>T	ENST00000023939.4	+	6	636	c.529G>T	c.(529-531)Gag>Tag	p.E177*	RTFDC1_ENST00000357348.5_Nonsense_Mutation_p.E207*|RTFDC1_ENST00000395881.3_Nonsense_Mutation_p.E177*|GCNT7_ENST00000243913.4_Intron	NM_016407.3	NP_057491.2			replication termination factor 2 domain containing 1																		TGGCACCAAGGAGGATGTGGA	0.557000													4	17					0.0215528	0.0220784	1	1	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994212	45994212	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:45994212C>A	ENST00000400374.3	+	1	607	c.577C>A	c.(577-579)Ccc>Acc	p.P193T	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	193	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GGTCTGTGAGCCCAGCCCCTG	0.642000													25	58					2.26627e-22	3.71811e-22	1	1	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276697	71276697	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:71276697G>T	ENST00000398531.1	+	1	89	c.64G>T	c.(64-66)Ggg>Tgg	p.G22W	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.G22W	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	22						keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						CTCCGGCTGTGGGGGCTGTGG	0.667000													62	82					1.4709e-25	2.56339e-25	1	1	0
SLC36A2	153201	broad.mit.edu	37	5	150704958	150704958	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:150704958G>T	ENST00000335244.4	-	8	1028	c.899C>A	c.(898-900)tCt>tAt	p.S300Y	SLC36A2_ENST00000521967.1_Missense_Mutation_p.S300Y|SLC36A2_ENST00000450886.1_Missense_Mutation_p.S24Y	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	300					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATTCCCAAAGACAGGATGGC	0.488000													11	57					0.000673444	0.000717884	1	1	0
OR8U1	219417	broad.mit.edu	37	11	56143841	56143841	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56143841G>T	ENST00000302270.1	+	1	742	c.742G>T	c.(742-744)Gtc>Ttc	p.V248F		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					CATGCTGGCAGTCACCATATT	0.483000													67	78					7.37877e-41	1.43145e-40	1	1	0
OR5T1	390155	broad.mit.edu	37	11	56043473	56043473	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56043473G>T	ENST00000313033.2	+	1	445	c.359G>T	c.(358-360)gGa>gTa	p.G120V		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TGTACTTTTGGAACCACAGAA	0.403000													50	242					2.13384e-23	3.59203e-23	1	1	0
LRIG3	121227	broad.mit.edu	37	12	59272721	59272721	+	Silent	SNP	G	G	C	rs140080436		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:59272721G>C	ENST00000320743.3	-	14	2254	c.1968C>G	c.(1966-1968)ccC>ccG	p.P656P	LRIG3_ENST00000379141.4_Silent_p.P596P	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	656	Ig-like C2-type 2.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CGTCATCCTCGGGCATCACAT	0.547000			T	ROS1	NSCLC								24	81					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529240	57529240	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:57529240G>T	ENST00000420713.1	+	4	1185	c.1073G>T	c.(1072-1074)gGg>gTg	p.G358V		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						GAAGAATGTGGGAAAGCCTTT	0.393000													17	29					4.14922e-12	5.58548e-12	1	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6087184	6087184	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:6087184G>T	ENST00000409021.3	-	4	1246	c.797C>A	c.(796-798)cCc>cAc	p.P266H	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.P266H|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.P266H|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.P101H|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.P101H	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	266	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCCGATCCCGGGCGGGAGCTC	0.607000													13	71					7.03913e-09	8.6572e-09	1	1	0
TRPM3	80036	broad.mit.edu	37	9	73736142	73736142	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:73736142G>A	ENST00000377110.2	-	1	372	c.129C>T	c.(127-129)atC>atT	p.I43I	TRPM3_ENST00000357533.2_Intron|TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000377111.2_Silent_p.I43I	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	43						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ACAGCTTCCGGATGGTCCAGT	0.458000													13	53					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216380620	216380620	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:216380620G>C	ENST00000366943.2	-	16	3697	c.3311C>G	c.(3310-3312)cCa>cGa	p.P1104R	USH2A_ENST00000366942.3_Missense_Mutation_p.P1104R|USH2A_ENST00000307340.3_Missense_Mutation_p.P1104R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1104	Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCACTGTATGGGTATTGATC	0.378000										HNSCC(13;0.011)			13	79					0	0	1	0	0
GPR17	2840	broad.mit.edu	37	2	128409268	128409268	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:128409268C>A	ENST00000544369.1	+	4	1654	c.1043C>A	c.(1042-1044)cCg>cAg	p.P348Q	LIMS2_ENST00000355119.4_Intron|LIMS2_ENST00000324938.5_Intron|GPR17_ENST00000272644.3_Missense_Mutation_p.P348Q|GPR17_ENST00000486700.1_3'UTR|LIMS2_ENST00000410011.1_Intron|LIMS2_ENST00000545738.2_Intron|GPR17_ENST00000393018.3_Missense_Mutation_p.P348Q|LIMS2_ENST00000409455.1_Intron|LIMS2_ENST00000409808.2_Intron	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	348						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		CTCAAGGGCCCGCCCCCCAGC	0.617000													15	84					1.3612e-06	1.5793e-06	1	1	0
ANO4	121601	broad.mit.edu	37	12	101477480	101477480	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:101477480G>T	ENST00000392979.3	+	15	1676	c.1315G>T	c.(1315-1317)Gcc>Tcc	p.A439S	ANO4_ENST00000550015.1_Intron|ANO4_ENST00000392977.3_Missense_Mutation_p.A474S|ANO4_ENST00000299222.9_Intron	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	474						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CCAGTTTGAAGCCAAGTATTC	0.383000										HNSCC(74;0.22)			22	91					3.5997e-14	5.0649e-14	1	1	0
ATRNL1	26033	broad.mit.edu	37	10	116919879	116919879	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:116919879T>C	ENST00000355044.3	+	6	1034	c.908T>C	c.(907-909)gTa>gCa	p.V303A	ATRNL1_ENST00000527407.1_Missense_Mutation_p.V303A|ATRNL1_ENST00000529665.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	303						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTCCTTCTGTAGGTCGGGCT	0.368000													41	277					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992159	85992159	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:85992159A>C	ENST00000372105.3	-	4	1417	c.1396T>G	c.(1396-1398)Ttt>Gtt	p.F466V		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	466	Fibronectin type-III.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						TGCTGCCCAAAGACCGCGTAG	0.582000													18	14					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17432531	17432531	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:17432531C>A	ENST00000377602.4	-	3	363	c.290_splice	c.e3+1	p.G97_splice	ST8SIA6-AS1_ENST00000457649.2_RNA|ST8SIA6-AS1_ENST00000451225.2_RNA|ST8SIA6-AS1_ENST00000377597.2_RNA	NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	97					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.G97W(1)		endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						AGAACTTACCCTTTCGTTTTG	0.363000													22	213					9.95505e-16	1.45938e-15	1	1	0
EGFLAM	133584	broad.mit.edu	37	5	38463032	38463032	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:38463032A>T	ENST00000322350.5	+	21	3140	c.2794A>T	c.(2794-2796)Acc>Tcc	p.T932S	EGFLAM_ENST00000506135.1_Missense_Mutation_p.T75S|CTD-2263F21.1_ENST00000510469.1_RNA|EGFLAM_ENST00000336740.6_Missense_Mutation_p.T698S|EGFLAM_ENST00000397202.2_Missense_Mutation_p.T298S|EGFLAM_ENST00000354891.3_Missense_Mutation_p.T940S|EGFLAM_ENST00000397210.3_Missense_Mutation_p.T75S|EGFLAM_ENST00000514476.1_Missense_Mutation_p.T75S	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	940	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					AGGAAAGATAACCGTGGATGA	0.448000													37	57					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94937377	94937377	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:94937377A>T	ENST00000222381.3	-	6	875	c.644T>A	c.(643-645)gTg>gAg	p.V215E	PON1_ENST00000542556.1_Missense_Mutation_p.V215E	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	215					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTCTGCCACCACTCGAACTTC	0.408000													31	77					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	45972732	45972732	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:45972732C>A	ENST00000296137.2	-	16	4287	c.4082G>T	c.(4081-4083)gGg>gTg	p.G1361V	FYCO1_ENST00000535325.1_Missense_Mutation_p.G1381V|FYCO1_ENST00000438446.1_Missense_Mutation_p.G32V	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1361	GOLD.				transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		GCTACCCTCCCCGAAGCTGGC	0.542000													19	22					1.15919e-05	1.30876e-05	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41101110	41101110	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:41101110G>T	ENST00000373198.3	-	8	1481	c.1246C>A	c.(1246-1248)Cgc>Agc	p.R416S	PTPRT_ENST00000356100.2_Missense_Mutation_p.R416S|PTPRT_ENST00000373190.1_Missense_Mutation_p.R416S|PTPRT_ENST00000373193.3_Missense_Mutation_p.R416S|PTPRT_ENST00000373187.1_Missense_Mutation_p.R416S|PTPRT_ENST00000373184.1_Missense_Mutation_p.R416S|PTPRT_ENST00000373201.1_Missense_Mutation_p.R416S	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	416	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTATGGCAGCGGGTCACCGCG	0.587000													41	34					1.59361e-14	2.25739e-14	1	1	0
OR5J2	282775	broad.mit.edu	37	11	55944498	55944498	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:55944498C>A	ENST00000312298.1	+	1	405	c.405C>A	c.(403-405)gcC>gcA	p.A135A		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					ACACTGTAGCCATGTCTGATA	0.453000													20	108					4.63292e-17	7.03735e-17	1	1	0
RHBDF2	79651	broad.mit.edu	37	17	74469806	74469806	+	Missense_Mutation	SNP	T	T	A	rs143001224		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:74469806T>A	ENST00000591885.1	-	15	2207	c.1657A>T	c.(1657-1659)Agg>Tgg	p.R553W	RHBDF2_ENST00000389760.4_Missense_Mutation_p.R553W|RHBDF2_ENST00000313080.4_Missense_Mutation_p.R582W			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	582					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						TGGTTGCTCCTGGCCTGCTCT	0.677000													6	19					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494170	55494170	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:55494170C>A	ENST00000543010.1	+	6	1247	c.1104C>A	c.(1102-1104)ttC>ttA	p.F368L	NLRP2_ENST00000339757.7_Missense_Mutation_p.F346L|NLRP2_ENST00000448584.2_Missense_Mutation_p.F368L|NLRP2_ENST00000537859.1_Missense_Mutation_p.F346L|NLRP2_ENST00000427260.2_Missense_Mutation_p.F345L|NLRP2_ENST00000263437.6_Missense_Mutation_p.F365L|NLRP2_ENST00000538819.1_Missense_Mutation_p.F344L|NLRP2_ENST00000391721.4_Missense_Mutation_p.F344L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	368	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGCCTATTTCCTGAGACACT	0.647000													3	35					0.000602214	0.000643588	1	1	0
TMCC2	9911	broad.mit.edu	37	1	205210776	205210776	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:205210776T>C	ENST00000358024.3	+	2	740	c.351T>C	c.(349-351)caT>caC	p.H117H	TMCC2_ENST00000545499.1_Silent_p.H39H|TMCC2_ENST00000495538.1_3'UTR	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	117						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGTCCGACCATGACTCCCCAG	0.642000													10	29					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24542889	24542889	+	Splice_Site	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:24542889T>A	ENST00000397016.2	+	4	659		c.e4+2		CPNE6_ENST00000216775.2_Splice_Site|CPNE6_ENST00000537691.1_Splice_Site|CPNE6_ENST00000560092.1_Splice_Site			O95741	CPNE6_HUMAN	copine VI (neuronal)						lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		TTGGGCCAGGTCTGCATTCCC	0.582000													20	13					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41585447	41585447	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:41585447G>A	ENST00000396942.1	-	4	389	c.306C>T	c.(304-306)gcC>gcT	p.A102A	ANK1_ENST00000352337.4_Silent_p.A102A|ANK1_ENST00000379758.2_Silent_p.A102A|ANK1_ENST00000289734.7_Silent_p.A102A|ANK1_ENST00000396945.1_Silent_p.A102A|ANK1_ENST00000265709.8_Silent_p.A135A|ANK1_ENST00000347528.4_Silent_p.A102A			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	102	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGTTGACGTTGGCTCCATAGT	0.582000													35	109					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233246361	233246361	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:233246361C>A	ENST00000392027.2	+	11	1733	c.1464C>A	c.(1462-1464)gcC>gcA	p.A488A	AC068134.8_ENST00000441266.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	488						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CCTTCGCCGCCTGCCTGGAGC	0.746000													17	12					3.73194e-20	5.91477e-20	1	1	0
SLC6A20	54716	broad.mit.edu	37	3	45837889	45837889	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:45837889C>A	ENST00000358525.4	-	1	138	c.23G>T	c.(22-24)tGg>tTg	p.W8L	SLC6A20_ENST00000456124.2_Missense_Mutation_p.W8L|SLC6A20_ENST00000353278.4_Missense_Mutation_p.W8L	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	8					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CGAGTTGGCCCACAGCGGCCG	0.711000													5	11					0.184627	0.186179	1	1	0
ASAP1	50807	broad.mit.edu	37	8	131200412	131200412	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:131200412G>A	ENST00000357668.1	-	5	450	c.423C>T	c.(421-423)caC>caT	p.H141H	ASAP1_ENST00000518721.1_Silent_p.H141H			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	141					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						AGATCACATTGTGGCTCAAAC	0.373000													66	255					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087817	92087817	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:92087817G>C	ENST00000298047.6	+	1	2556	c.2539G>C	c.(2539-2541)Ggt>Cgt	p.G847R	FAT3_ENST00000525166.1_Missense_Mutation_p.G697R|FAT3_ENST00000409404.2_Missense_Mutation_p.G847R|FAT3_ENST00000541502.1_Missense_Mutation_p.G847R			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	847	Cadherin 8.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCAGGCATTGGTACTGAAAT	0.403000										TCGA Ovarian(4;0.039)			60	65					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677025	37677025	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:37677025C>A	ENST00000532828.2	-	5	1665	c.1414G>T	c.(1414-1416)Ggg>Tgg	p.G472W	CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000531805.1_Missense_Mutation_p.G417W|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000312908.5_Missense_Mutation_p.G60W	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATGCCTTCCCACATTTATTG	0.393000													115	75					1.87388e-53	3.7567e-53	1	1	0
HTR1B	3351	broad.mit.edu	37	6	78172176	78172176	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:78172176G>T	ENST00000369947.2	-	1	1314	c.945C>A	c.(943-945)acC>acA	p.T315T		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	315					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	TGATCCCTAGGGTCTTGGTGG	0.512000													39	139					1.57019e-19	2.46997e-19	1	1	0
BCR	613	broad.mit.edu	37	22	23603638	23603638	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:23603638G>T	ENST00000305877.8	+	4	2414	c.1663G>T	c.(1663-1665)Gag>Tag	p.E555*	BCR_ENST00000359540.3_Nonsense_Mutation_p.E555*	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	555	DH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						TGAGCTCTACGAGATCCACAA	0.592000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								25	114					3.01185e-09	3.73701e-09	1	1	0
SMC2	10592	broad.mit.edu	37	9	106864430	106864430	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:106864430G>C	ENST00000286398.7	+	8	1114	c.826G>C	c.(826-828)Gca>Cca	p.A276P	SMC2_ENST00000374787.3_Missense_Mutation_p.A276P|SMC2_ENST00000303219.8_Missense_Mutation_p.A276P|SMC2_ENST00000374793.3_Missense_Mutation_p.A276P	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	276					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						AAAAATAAAAGCACTTAATCA	0.284000													19	38					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138440503	138440503	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:138440503G>T	ENST00000310018.2	-	10	1029	c.747C>A	c.(745-747)tgC>tgA	p.C249*	ATP6V0A4_ENST00000393054.1_Nonsense_Mutation_p.C249*|ATP6V0A4_ENST00000353492.4_Nonsense_Mutation_p.C249*	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	249					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAGGCTCTGGGCAAGGGTAGA	0.502000													5	45					0.014758	0.0151549	1	1	0
PTGS1	5742	broad.mit.edu	37	9	125140711	125140711	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:125140711G>T	ENST00000362012.2	+	4	216		c.e4-1		PTGS1_ENST00000540753.1_Splice_Site|PTGS1_ENST00000373698.5_Splice_Site|PTGS1_ENST00000223423.4_Splice_Site	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)						cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TGCCCCTGCAGCTGGCCTGTG	0.607000													20	172					1.55795e-14	2.2106e-14	1	1	0
BTBD16	118663	broad.mit.edu	37	10	124092011	124092011	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:124092011G>A	ENST00000368994.2	+	13	1401	c.1150G>A	c.(1150-1152)Ggg>Agg	p.G384R	BTBD16_ENST00000495370.2_3'UTR|BTBD16_ENST00000260723.4_Missense_Mutation_p.G383R			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	383										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TGTGAGATTTGGGCTGCTCTT	0.512000													52	26					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134990	233134990	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:233134990C>G	ENST00000258229.8	-	31	5698	c.5464G>C	c.(5464-5466)Gat>Cat	p.D1822H	PCNXL2_ENST00000344698.2_Missense_Mutation_p.D474H	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1822						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGGGGCTGATCGCAGGAGGAG	0.542000													13	26					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809043	18809043	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:18809043G>C	ENST00000400664.1	+	1	1620	c.1568G>C	c.(1567-1569)cGc>cCc	p.R523P		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	523						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCTGGCTCGCATGCCCCCC	0.672000													27	53					0	0	1	0	0
OLFML1	283298	broad.mit.edu	37	11	7530966	7530966	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:7530966C>A	ENST00000329293.3	+	3	1150	c.756C>A	c.(754-756)ctC>ctA	p.L252L	OLFML1_ENST00000530135.1_Silent_p.L252L|CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000528758.1_3'UTR	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	252	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GAATGCTGCTCCCAGGAGGGG	0.478000													19	27					8.34094e-07	9.70414e-07	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112673516	112673516	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:112673516T>C	ENST00000550722.1	-	36	5474	c.5079A>G	c.(5077-5079)caA>caG	p.Q1693Q	HECTD4_ENST00000430131.2_Silent_p.Q1417Q|HECTD4_ENST00000377560.5_Silent_p.Q1667Q	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GAGACGGGCGTTGGTCAAGCA	0.552000													7	43					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476575	42476575	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:42476575C>A	ENST00000434000.1	-	9	2918	c.2636G>T	c.(2635-2637)cGg>cTg	p.R879L	GPATCH8_ENST00000591680.1_Missense_Mutation_p.R957L			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	957	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GCTGCGGCCCCGGGATCTTGA	0.577000													36	38					2.47316e-13	3.42249e-13	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248201571	248201571	+	Translation_Start_Site	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248201571T>A	ENST00000366479.2	+	1	98	c.2T>A	c.(1-3)aTg>aAg	p.M1K	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GAATTCCCCATGGAAAATTAC	0.388000													21	186					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120773890	120773890	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:120773890G>T	ENST00000310396.5	+	13	2058	c.1591G>T	c.(1591-1593)Gaa>Taa	p.E531*	CPED1_ENST00000423795.1_Nonsense_Mutation_p.E311*|CPED1_ENST00000450913.2_Nonsense_Mutation_p.E531*	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TTCTTTCACAGAAGATAAGAA	0.303000													7	128					0.00198382	0.00208823	1	1	0
MRPL42	28977	broad.mit.edu	37	12	93881322	93881322	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:93881322A>T	ENST00000549982.1	+	5	430	c.269A>T	c.(268-270)cAa>cTa	p.Q90L	MRPL42_ENST00000361630.2_Missense_Mutation_p.Q90L|MRPL42_ENST00000393128.4_Missense_Mutation_p.Q90L|MRPL42_ENST00000547098.1_Missense_Mutation_p.Q90L|MRPL42_ENST00000548545.1_Missense_Mutation_p.Q90L|MRPL42_ENST00000552217.1_Missense_Mutation_p.Q90L	NM_014050.3|NM_172177.3	NP_054769.1|NP_751917.1	Q9Y6G3	RM42_HUMAN	mitochondrial ribosomal protein L42	90					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)	7						ACACATGATCAAGTGCTGAAA	0.393000													23	69					0	0	1	0	0
CTLA4	1493	broad.mit.edu	37	2	204735475	204735475	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:204735475G>T	ENST00000302823.3	+	2	433	c.276G>T	c.(274-276)ggG>ggT	p.G92G	CTLA4_ENST00000427473.2_Silent_p.G55G|CTLA4_ENST00000472206.1_Intron|CTLA4_ENST00000487393.1_Intron|CTLA4_ENST00000295854.6_Silent_p.G92G	NM_005214.4	NP_005205.2	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	92	Ig-like V-type.				B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm				large_intestine(4)|lung(4)|skin(1)	9					Abatacept(DB01281)	ACATGATGGGGAATGAGTTGA	0.552000													56	85					9.72345e-25	1.67029e-24	1	1	0
FAT3	120114	broad.mit.edu	37	11	92495068	92495068	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:92495068G>T	ENST00000298047.6	+	4	3733	c.3716G>T	c.(3715-3717)tGg>tTg	p.W1239L	FAT3_ENST00000525166.1_Missense_Mutation_p.W1089L|FAT3_ENST00000409404.2_Missense_Mutation_p.W1239L|RP11-203F8.1_ENST00000529884.1_RNA			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1239	Cadherin 11.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCAACCATTTGGGTGGTGGTT	0.448000										TCGA Ovarian(4;0.039)			177	167					7.56914e-101	1.53949e-100	1	1	0
TNFRSF13C	115650	broad.mit.edu	37	22	42322154	42322154	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:42322154C>A	ENST00000291232.3	-	2	362	c.318G>T	c.(316-318)cgG>cgT	p.R106R		NM_052945.3	NP_443177.1	Q96RJ3	TR13C_HUMAN	tumor necrosis factor receptor superfamily, member 13C	106						integral to membrane	receptor activity			lung(2)|urinary_tract(1)	3						CGCGAAGCCGCCGCTGTCGCC	0.736000													7	17					0.27861	0.279943	1	1	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363243	21363243	+	RNA	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:21363243G>C	ENST00000452284.1	+	0	910				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						CTCGAAGCGGGCACTGGCGAT	0.587000													33	70					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60585185	60585185	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:60585185T>A	ENST00000406854.1	+	7	2271	c.1717T>A	c.(1717-1719)Tct>Act	p.S573T	PCNXL4_ENST00000317623.4_Missense_Mutation_p.S339T|PCNXL4_ENST00000404681.2_Missense_Mutation_p.S573T|PCNXL4_ENST00000406949.1_Missense_Mutation_p.S339T|PCNXL4_ENST00000535349.1_5'UTR					pecanex-like 4 (Drosophila)																		CATTGTCTTTTCTCCATTCGT	0.423000													16	18					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779622	133779622	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:133779622G>A	ENST00000372338.4	-	7	1457	c.1215C>T	c.(1213-1215)taC>taT	p.Y405Y	FIBCD1_ENST00000448616.1_Silent_p.Y405Y|FIBCD1_ENST00000253018.4_Intron|FIBCD1_ENST00000372337.2_Silent_p.Y247Y	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	405	Fibrinogen C-terminal.	Implicated in ligand binding.			signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		AGGCACCGCGGTAGAAGGCGG	0.637000													13	59					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701143	143701143	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:143701143T>A	ENST00000408922.2	+	1	122	c.54T>A	c.(52-54)ccT>ccA	p.P18P		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TGGGATTCCCTGGGAGCTTGA	0.478000													29	56					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33944929	33944929	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:33944929C>A	ENST00000296589.4	-	7	1563	c.1417G>T	c.(1417-1419)Ggc>Tgc	p.G473C	SLC45A2_ENST00000342059.3_Missense_Mutation_p.G414C	NM_016180.3	NP_057264.3	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	473					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						CAGTCCATGCCCTTCCCTCTC	0.592000													25	16					4.26978e-12	5.73858e-12	1	1	0
PRRG1	5638	broad.mit.edu	37	X	37312723	37312723	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:37312723C>T	ENST00000542554.1	+	5	778	c.506C>T	c.(505-507)cCg>cTg	p.P169L	PRRG1_ENST00000491253.1_3'UTR|PRRG1_ENST00000449135.2_Missense_Mutation_p.P169L|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000378628.4_Missense_Mutation_p.P169L|PRRG1_ENST00000543642.1_Missense_Mutation_p.P169L	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	169						extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						TGTGATCCCCCGCCAACCTAT	0.517000													41	37					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	22078634	22078634	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:22078634C>G	ENST00000382254.1	-	5	1238	c.152G>C	c.(151-153)cGt>cCt	p.R51P	CDH12_ENST00000504376.2_Missense_Mutation_p.R51P|CDH12_ENST00000522262.1_Missense_Mutation_p.R51P	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	51					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						ACGTTTAACACGTTGGAAATG	0.468000										HNSCC(59;0.17)			80	190					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220707	1220707	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:1220707G>T	ENST00000326873.7	+	5	1898	c.725G>T	c.(724-726)gGg>gTg	p.G242V		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	242	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.G242V(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTCGGCTGGGGTCACCCTG	0.706000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			28	14					7.11191e-15	1.0212e-14	1	1	0
GRID1	2894	broad.mit.edu	37	10	87379741	87379741	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:87379741T>A	ENST00000327946.7	-	14	2328	c.2243A>T	c.(2242-2244)tAc>tTc	p.Y748F	GRID1_ENST00000536331.1_Missense_Mutation_p.Y319F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	748						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CAGGGCTGCGTATTCCACCAC	0.567000										Multiple Myeloma(13;0.14)			24	23					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102750973	102750973	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:102750973A>G	ENST00000504592.1	+	6	452	c.34A>G	c.(34-36)Aaa>Gaa	p.K12E	BANK1_ENST00000508653.1_Intron|BANK1_ENST00000444316.2_5'UTR|BANK1_ENST00000428908.1_Intron|BANK1_ENST00000322953.4_Missense_Mutation_p.K27E			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	27	Interaction with ITPR2.				B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGGAAATACAAAAGATATAAT	0.294000													12	23					0	0	1	0	0
SSBP1	6742	broad.mit.edu	37	7	141443384	141443384	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:141443384G>T	ENST00000481508.1	+	4	544	c.109G>T	c.(109-111)Ggg>Tgg	p.G37W	SSBP1_ENST00000465582.1_Missense_Mutation_p.G37W|SSBP1_ENST00000469123.1_3'UTR|SSBP1_ENST00000484178.1_Missense_Mutation_p.G37W|SSBP1_ENST00000498107.1_Missense_Mutation_p.G37W|SSBP1_ENST00000265304.6_Missense_Mutation_p.G37W	NM_001256510.1	NP_001243439.1	Q04837	SSBP_HUMAN	single-stranded DNA binding protein 1, mitochondrial	37	SSB.				DNA replication|positive regulation of helicase activity	mitochondrial nucleoid	single-stranded DNA binding			large_intestine(3)|lung(1)|ovary(1)|pancreas(1)|skin(1)	7	Melanoma(164;0.0171)					GCACTTACTTGGGCGAGTGGG	0.458000													11	125					1.58986e-06	1.84205e-06	1	1	0
OPLAH	26873	broad.mit.edu	37	8	145110063	145110063	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:145110063C>A	ENST00000426825.1	-	17	2359	c.2278G>T	c.(2278-2280)Gcc>Tcc	p.A760S	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	760							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GTGGAGATGGCTGTGCGCTGC	0.642000													10	43					2.17888e-05	2.43709e-05	1	1	0
S100A7L2	645922	broad.mit.edu	37	1	153410822	153410822	+	Splice_Site	SNP	C	C	A	rs10888561	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:153410822C>A	ENST00000368725.2	-	2	16	c.16_splice	c.e2-1	p.G6_splice		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTTCAAAAAGCCTTCAGGAAA	0.408000													5	91					0.000602214	0.000643588	1	1	0
ZNF280B	140883	broad.mit.edu	37	22	22842223	22842223	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:22842223C>A	ENST00000360412.2	-	4	2276	c.1501G>T	c.(1501-1503)Gtt>Ttt	p.V501F	ZNF280B_ENST00000406426.1_Missense_Mutation_p.V501F	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TGAATAGTAACTTTTGTTTCA	0.428000													88	92					2.93434e-44	5.73219e-44	1	1	0
VIL1	7429	broad.mit.edu	37	2	219301287	219301287	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:219301287C>G	ENST00000248444.5	+	16	1997	c.1909C>G	c.(1909-1911)Cct>Gct	p.P637A	VIL1_ENST00000392114.2_Missense_Mutation_p.P326A	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	637	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACAGAGATCCCTGACTTCAA	0.552000													66	129					0	0	1	0	0
VWC2	375567	broad.mit.edu	37	7	49842391	49842391	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:49842391G>T	ENST00000340652.3	+	3	1337	c.781G>T	c.(781-783)Gac>Tac	p.D261Y		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	261	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GGAGTGTGTGGACCCTGTGTA	0.577000													36	56					5.71845e-15	8.23928e-15	1	1	0
POP1	10940	broad.mit.edu	37	8	99169904	99169904	+	Missense_Mutation	SNP	G	G	T	rs142048689		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:99169904G>T	ENST00000401707.2	+	16	2561	c.2480G>T	c.(2479-2481)cGg>cTg	p.R827L	POP1_ENST00000349693.3_Missense_Mutation_p.R827L	NM_001145860.1|NM_001145861.1	NP_001139332.1|NP_001139333.1	Q99575	POP1_HUMAN	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)	827					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			autonomic_ganglia(1)|breast(3)|endometrium(4)|large_intestine(9)|lung(15)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GAGGATAGTCGGGGAGGCCGG	0.557000													36	171					9.62906e-15	1.37558e-14	1	1	0
MICU3	286097	broad.mit.edu	37	8	16921649	16921649	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:16921649G>T	ENST00000318063.5	+	2	480	c.438G>T	c.(436-438)gaG>gaT	p.E146D		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		CATCTCGGGAGAGGCGATTTC	0.378000													58	58					5.86059e-21	9.43083e-21	1	1	0
OR2M3	127062	broad.mit.edu	37	1	248367069	248367069	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248367069C>A	ENST00000456743.1	+	1	738	c.700C>A	c.(700-702)Cgt>Agt	p.R234S		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGAGAGGGTCGTCGCAAAGC	0.463000													43	405					8.48111e-28	1.52225e-27	1	1	0
NOS1	4842	broad.mit.edu	37	12	117701725	117701725	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:117701725G>T	ENST00000317775.6	-	13	2876	c.2191C>A	c.(2191-2193)Cgg>Agg	p.R731R	NOS1_ENST00000338101.4_Silent_p.R731R|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	731	Calmodulin-binding (Potential).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ATGGCTCGCCGCTTTGTGGGG	0.582000													69	76					1.7666e-45	3.47528e-45	1	1	0
HTR3B	9177	broad.mit.edu	37	11	113803667	113803667	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:113803667T>C	ENST00000260191.2	+	6	805	c.548T>C	c.(547-549)gTa>gCa	p.V183A	HTR3B_ENST00000537778.1_Missense_Mutation_p.V172A	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	183			V -> I (in dbSNP:rs17116138).		synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GTGGAAGACGTAGACCTGGCC	0.468000													28	27					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79259794	79259794	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:79259794C>A	ENST00000428286.1	-	12	8715	c.7515G>T	c.(7513-7515)gaG>gaT	p.E2505D	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2863D|PRUNE2_ENST00000466266.2_5'UTR|PRUNE2_ENST00000443509.2_Missense_Mutation_p.E112D|PRUNE2_ENST00000223609.6_Missense_Mutation_p.E128D			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2863					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TAGACTCTGACTCTTGGCCAG	0.502000													3	22					1	1	1	1	0
FHOD3	80206	broad.mit.edu	37	18	34191969	34191969	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:34191969G>T	ENST00000257209.4	+	9	990	c.868G>T	c.(868-870)Gag>Tag	p.E290*	FHOD3_ENST00000591635.1_5'UTR|FHOD3_ENST00000590592.1_Nonsense_Mutation_p.E290*|FHOD3_ENST00000359247.4_Nonsense_Mutation_p.E290*|FHOD3_ENST00000445677.1_Nonsense_Mutation_p.E290*	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	290	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GGACTGCCTGGAGGAGCTGGG	0.517000													30	47					2.12542e-12	2.8796e-12	1	1	0
TTBK1	84630	broad.mit.edu	37	6	43222304	43222304	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:43222304G>T	ENST00000259750.4	+	6	574	c.491G>T	c.(490-492)aGg>aTg	p.R164M	TTBK1_ENST00000304139.5_Missense_Mutation_p.R113M	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	164	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GCCATGGGCAGGCTGCCCTCC	0.642000													16	69					1.15088e-07	1.37516e-07	1	1	0
MYT1	4661	broad.mit.edu	37	20	62836948	62836948	+	Silent	SNP	C	C	A	rs148041017	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:62836948C>A	ENST00000536311.1	+	6	556	c.192C>A	c.(190-192)ggC>ggA	p.G64G	MYT1_ENST00000328439.1_Silent_p.G64G|MYT1_ENST00000360149.4_Silent_p.G64G			Q01538	MYT1_HUMAN	myelin transcription factor 1	64					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGCTGGAGGGCGCTGAGGCTG	0.627000													12	100					0.00136819	0.00144746	1	1	0
TRIM42	287015	broad.mit.edu	37	3	140401978	140401978	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:140401978G>T	ENST00000286349.3	+	2	1207	c.1016G>T	c.(1015-1017)aGc>aTc	p.S339I		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	339						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TCACTCTTCAGCGCCATCGCC	0.532000													11	68					3.86212e-05	4.28558e-05	1	1	0
ITPR2	3709	broad.mit.edu	37	12	26775302	26775302	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:26775302T>C	ENST00000381340.3	-	25	3575	c.3159A>G	c.(3157-3159)ggA>ggG	p.G1053G	ITPR2_ENST00000545902.1_5'UTR	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1053					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					ACGTCCTGCCTCCTTCATCGT	0.408000													28	33					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404447	10404447	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:10404447C>A	ENST00000226207.5	-	27	3812	c.3718G>T	c.(3718-3720)Gag>Tag	p.E1240*	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1240						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GAGACAGTCTCCATGTTACTA	0.418000													79	60					3.23364e-46	6.39119e-46	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190068181	190068181	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:190068181G>A	ENST00000367462.3	-	8	1499	c.1268C>T	c.(1267-1269)aCg>aTg	p.T423M	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.T321M	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		423						extracellular region		p.T423M(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GCACGAGTGCGTCTCTTCTGA	0.547000													11	56					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154427	22154427	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:22154427C>A	ENST00000397126.4	-	4	3557	c.3409G>T	c.(3409-3411)Gga>Tga	p.G1137*	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGTTTCTCTCCAGTATGAATT	0.363000													42	43					1.34996e-11	1.80281e-11	1	1	0
BRCA1	672	broad.mit.edu	37	17	41245429	41245429	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:41245429C>G	ENST00000309486.4	-	9	2258	c.1231G>C	c.(1231-1233)Ggt>Cgt	p.G411R	BRCA1_ENST00000357654.3_Missense_Mutation_p.G707R|BRCA1_ENST00000354071.3_Missense_Mutation_p.G707R|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000493795.1_Missense_Mutation_p.G660R|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.G707R|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000471181.2_Missense_Mutation_p.G707R	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	707					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GTAAAAGAACCAGGTGCATTT	0.378000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			19	84					0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70363206	70363206	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:70363206C>T	ENST00000288071.6	+	8	864	c.619C>T	c.(619-621)Cag>Tag	p.Q207*	DDX19B_ENST00000568625.1_Nonsense_Mutation_p.Q98*|RP11-529K1.3_ENST00000567706.1_Intron|DDX19B_ENST00000451014.3_Nonsense_Mutation_p.Q181*|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000355992.3_Nonsense_Mutation_p.Q176*|DDX19B_ENST00000563206.1_Nonsense_Mutation_p.Q212*|DDX19B_ENST00000563392.1_Nonsense_Mutation_p.Q98*|DDX19B_ENST00000393657.2_Nonsense_Mutation_p.Q98*	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	207	Helicase ATP-binding.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				GGAAAGAGGCCAGAAGATCAG	0.428000													39	57					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117509804	117509804	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:117509804G>T	ENST00000393203.2	+	6	2058	c.1911G>T	c.(1909-1911)gaG>gaT	p.E637D	PTGFRN_ENST00000496699.1_3'UTR	NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	637	Ig-like C2-type 5.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AGGAGGATGAGTTCCGCTATC	0.537000													58	83					3.76997e-23	6.29577e-23	1	1	0
GRM8	2918	broad.mit.edu	37	7	126746692	126746692	+	Silent	SNP	C	C	A	rs144653566		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:126746692C>A	ENST00000339582.2	-	3	1393	c.585G>T	c.(583-585)gtG>gtT	p.V195V	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000405249.1_Silent_p.V195V|GRM8_ENST00000358373.3_Silent_p.V195V|GRM8_ENST00000444921.2_Silent_p.V195V			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	195					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CAGGCGGAACCACTCGAGAGA	0.488000										HNSCC(24;0.065)			7	55					0.00198382	0.00208823	1	1	0
SCN2A	6326	broad.mit.edu	37	2	166183488	166183488	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:166183488A>T	ENST00000375437.2	+	13	2433	c.2143A>T	c.(2143-2145)Atg>Ttg	p.M715L	SCN2A_ENST00000375427.2_Missense_Mutation_p.M715L|SCN2A_ENST00000357398.3_Missense_Mutation_p.M715L|SCN2A_ENST00000283256.6_Missense_Mutation_p.M715L	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	715					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GACCAACACCATGGAAGGTAT	0.363000													83	52					0	0	1	0	0
TMEM38B	55151	broad.mit.edu	37	9	108468021	108468021	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:108468021G>T	ENST00000374688.1	+	2	804	c.94G>T	c.(94-96)Gca>Tca	p.A32S	TMEM38B_ENST00000374692.3_Missense_Mutation_p.A86S			Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	86				A -> E (in Ref. 2; CAG33539).		integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						CATATTACTGGCATCTTCAAT	0.363000													32	66					9.78485e-24	1.65711e-23	1	1	0
GPR141	353345	broad.mit.edu	37	7	37780137	37780137	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:37780137C>G	ENST00000447769.1	+	4	431	c.142C>G	c.(142-144)Cgg>Ggg	p.R48G	GPR141_ENST00000461610.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.R48G|EPDR1_ENST00000476620.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	48						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R48R(1)		NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AATGAACACCCGGTCAGTGAC	0.488000													40	96					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71158552	71158552	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:71158552G>T	ENST00000283228.2	-	3	816	c.364C>A	c.(364-366)Caa>Aaa	p.Q122K	PTPRR_ENST00000342084.4_Missense_Mutation_p.Q10K	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	122					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ACATCCATTTGCAGTGTCTAG	0.363000													15	61					0.000308642	0.000334097	1	1	0
ADAM2	2515	broad.mit.edu	37	8	39645620	39645620	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:39645620C>T	ENST00000265708.4	-	9	896	c.793G>A	c.(793-795)Gtg>Atg	p.V265M	ADAM2_ENST00000521880.1_Missense_Mutation_p.V265M|ADAM2_ENST00000347580.4_Missense_Mutation_p.V246M|ADAM2_ENST00000379853.2_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	265	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AAAAATGCCACATCATGAGGA	0.294000													29	150					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47311202	47311202	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:47311202C>A	ENST00000426342.1	-	17	2862	c.2116G>T	c.(2116-2118)Ggg>Tgg	p.G706W	MDGA2_ENST00000399222.3_Missense_Mutation_p.G137W|MDGA2_ENST00000439988.2_Missense_Mutation_p.G935W|MDGA2_ENST00000357362.3_Missense_Mutation_p.G706W|MDGA2_ENST00000399232.2_Missense_Mutation_p.G1004W	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	935					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						ACCAAAATCCCAACAGCACCA	0.378000													22	23					1.50039e-11	1.9879e-11	1	1	0
ZRANB2	9406	broad.mit.edu	37	1	71538211	71538211	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:71538211C>A	ENST00000370920.3	-	5	623	c.322G>T	c.(322-324)Gaa>Taa	p.E108*	ZRANB2_ENST00000254821.6_Nonsense_Mutation_p.E108*	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	108					mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						TTTTCTCTTTCATTAAAACCA	0.303000													31	67					6.38683e-12	8.57019e-12	1	1	0
PCDH17	27253	broad.mit.edu	37	13	58299071	58299071	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:58299071G>T	ENST00000377918.3	+	4	3149	c.3123G>T	c.(3121-3123)aaG>aaT	p.K1041N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1041					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCCCAACCAAGGCGTGCATCG	0.532000													22	55					8.10497e-08	9.78186e-08	1	1	0
HIST1H3F	8968	broad.mit.edu	37	6	26250504	26250504	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:26250504C>G	ENST00000446824.2	-	1	331	c.330G>C	c.(328-330)ctG>ctC	p.L110L		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	110					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						GGATAGCACACAGGTTGGTGT	0.602000											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	76					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58933072	58933072	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:58933072C>A	ENST00000260408.3	-	8	1359	c.916G>T	c.(916-918)Gag>Tag	p.E306*	ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	306	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TGATTCTGCTCAGAATTCAAT	0.428000													45	34					1.6237e-14	2.29614e-14	1	1	0
TFCP2	7024	broad.mit.edu	37	12	51511500	51511500	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:51511500T>A	ENST00000307660.4	-	3	1025	c.305A>T	c.(304-306)aAt>aTt	p.N102I	TFCP2_ENST00000257915.5_Missense_Mutation_p.N102I|TFCP2_ENST00000549867.1_Missense_Mutation_p.N102I|TFCP2_ENST00000548115.1_Missense_Mutation_p.N102I	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	102					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						AAGTTTCCTATTGTCTAGCAT	0.294000													19	29					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402328	248402328	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248402328G>T	ENST00000306687.1	+	1	98	c.98G>T	c.(97-99)gGc>gTc	p.G33V		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGGTCCTGGGCATCTTCTCA	0.478000													28	210					1.50538e-07	1.7911e-07	1	1	0
FLG	2312	broad.mit.edu	37	1	152286901	152286901	+	Missense_Mutation	SNP	G	G	C	rs141507246		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:152286901G>C	ENST00000368799.1	-	3	496	c.461C>G	c.(460-462)tCt>tGt	p.S154C	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	154					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAGAACTAGATTCATGCCT	0.353000									Ichthyosis				26	177					0	0	1	0	0
EIF5B	9669	broad.mit.edu	37	2	99977666	99977666	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:99977666A>G	ENST00000289371.5	+	4	504	c.302A>G	c.(301-303)cAg>cGg	p.Q101R		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	101					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAGAAAGGACAGAAGGGCAAA	0.294000													15	65					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168482	142168482	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142168482G>T	ENST00000454561.2	-	0	441																											GAGAATCTAGGAGGGAAGTTT	0.522000													24	85					4.4194e-11	5.7734e-11	1	1	0
TRPC4	7223	broad.mit.edu	37	13	38229378	38229378	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:38229378C>G	ENST00000379705.3	-	7	2588	c.1731G>C	c.(1729-1731)ggG>ggC	p.G577G	TRPC4_ENST00000355779.2_Silent_p.G577G|TRPC4_ENST00000447043.1_Silent_p.G577G|TRPC4_ENST00000379681.3_Silent_p.G577G|TRPC4_ENST00000379673.2_Silent_p.G577G|TRPC4_ENST00000358477.2_Silent_p.G577G|TRPC4_ENST00000338947.5_Silent_p.G404G|TRPC4_ENST00000379679.1_Silent_p.G404G|TRPC4_ENST00000426868.2_3'UTR			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	577					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AATTGATGAGCCCAAATATTG	0.358000													8	25					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32154671	32154671	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:32154671G>A	ENST00000373672.3	-	24	2152	c.1636C>T	c.(1636-1638)Caa>Taa	p.Q546*	COL16A1_ENST00000373668.3_Nonsense_Mutation_p.Q546*|COL16A1_ENST00000271069.6_Nonsense_Mutation_p.Q546*	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	546	Triple-helical region 8 (COL8) with 1 imperfection.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TTGATGCCTTGGATGCCAGGG	0.577000													17	85					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65147232	65147232	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:65147232C>A	ENST00000381210.3	-	10	988	c.878G>T	c.(877-879)tGg>tTg	p.W293L	TECRL_ENST00000507440.1_Missense_Mutation_p.W293L	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	293					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GAAAAACATCCATGTGAAGGG	0.343000													19	39					5.26018e-13	7.23167e-13	1	1	0
MCM2	4171	broad.mit.edu	37	3	127327831	127327831	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:127327831A>T	ENST00000265056.7	+	8	1637	c.1393A>T	c.(1393-1395)Act>Tct	p.T465S		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	465					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GAAGATGATCACTAGCCTCTC	0.552000													55	92					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49580203	49580203	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:49580203G>T	ENST00000371175.4	-	6	878	c.852C>A	c.(850-852)ggC>ggA	p.G284G	RHAG_ENST00000229810.7_Silent_p.G284G	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	284					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					CCGCACAAGTGCCCACAGCAA	0.468000													13	66					0.00010058	0.000109581	1	1	0
NOS1AP	9722	broad.mit.edu	37	1	162335208	162335208	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:162335208G>T	ENST00000493151.1	+	1	2436	c.69G>T	c.(67-69)aaG>aaT	p.K23N	NOS1AP_ENST00000530878.1_Missense_Mutation_p.K313N|RP11-565P22.6_ENST00000431696.1_Missense_Mutation_p.K4N|NOS1AP_ENST00000361897.5_Missense_Mutation_p.K318N	NM_001126060.1	NP_001119532.2	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	318					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			ACTTGCTGAAGGACCAGTTGG	0.592000													37	95					2.87052e-16	4.27524e-16	1	1	0
ASIC2	40	broad.mit.edu	37	17	31355322	31355322	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:31355322C>T	ENST00000225823.2	-	4	1948	c.1076G>A	c.(1075-1077)aGg>aAg	p.R359K	ASIC2_ENST00000448983.1_5'UTR|ASIC2_ENST00000359872.6_Missense_Mutation_p.R308K	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	308					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	ACAGTCAATCCTACAGGCGGT	0.582000													17	61					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124207162	124207162	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:124207162G>C	ENST00000360013.3	+	29	4517	c.4390_splice	c.e29+1	p.G1464_splice	KALRN_ENST00000240874.3_Splice_Site_p.G1464_splice|KALRN_ENST00000460856.1_Splice_Site_p.G1455_splice	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1464					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CATGCTGGAAGGTAGCTGTCC	0.542000													19	32					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51075886	51075886	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:51075886G>A	ENST00000376006.3	+	2	289	c.69G>A	c.(67-69)ctG>ctA	p.L23L	NUDT10_ENST00000356450.2_Silent_p.L23L	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	23	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					CGGCGTGCCTGTGCTTCCGGA	0.677000													5	28					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730441	37730441	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:37730441C>A	ENST00000330843.4	-	4	1891	c.1879G>T	c.(1879-1881)Gga>Tga	p.G627*	RAB11FIP1_ENST00000523182.1_5'UTR|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000524118.1_Intron	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	627					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AAGGGTGGTCCTTCAGACTTG	0.512000													40	162					4.32679e-17	6.58425e-17	1	1	0
MYBPC1	4604	broad.mit.edu	37	12	102057294	102057294	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:102057294C>A	ENST00000549145.1	+	21	2376	c.2276C>A	c.(2275-2277)gCa>gAa	p.A759E	MYBPC1_ENST00000541119.1_Missense_Mutation_p.A734E|MYBPC1_ENST00000536007.1_Missense_Mutation_p.A727E|MYBPC1_ENST00000392934.3_Missense_Mutation_p.A733E|MYBPC1_ENST00000553190.1_Missense_Mutation_p.A746E|MYBPC1_ENST00000452455.2_Missense_Mutation_p.A746E|MYBPC1_ENST00000441232.1_Missense_Mutation_p.A746E|MYBPC1_ENST00000551300.1_Missense_Mutation_p.A647E|MYBPC1_ENST00000361466.2_Missense_Mutation_p.A771E|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000550270.1_Missense_Mutation_p.A746E|MYBPC1_ENST00000361685.2_Missense_Mutation_p.A771E|MYBPC1_ENST00000547509.1_Missense_Mutation_p.A732E|MYBPC1_ENST00000547405.1_Missense_Mutation_p.A720E|MYBPC1_ENST00000545503.2_Missense_Mutation_p.A746E|MYBPC1_ENST00000360610.2_Missense_Mutation_p.A746E			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	746	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						CACATTGGTGCAGCAGGTTTA	0.458000													19	50					2.35188e-11	3.09652e-11	1	1	0
ANXA8L1	728113	broad.mit.edu	37	10	47158850	47158850	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:47158850C>G	ENST00000359178.4	-	12	1092	c.971G>C	c.(970-972)gGc>gCc	p.G324A	ANXA8L1_ENST00000358140.4_Missense_Mutation_p.G273A|ANXA8L1_ENST00000414655.2_Missense_Mutation_p.G262A|ANXA8L1_ENST00000545298.1_3'UTR	NM_001098845.1	NP_001092315.1	Q5T2P8	AXA81_HUMAN	annexin A8-like 1	324							calcium ion binding|calcium-dependent phospholipid binding			large_intestine(1)|lung(1)	2						GGGGTCGCTGCCCACCAGGCT	0.607000													4	4					0	0	1	0	0
IGKV3-20	28912	broad.mit.edu	37	2	89442319	89442319	+	RNA	SNP	C	C	G	rs1056458	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:89442319C>G	ENST00000492167.1	-	0	137																											AGACAGGGTGCCTGGAGACTG	0.498000													5	93					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21797140	21797140	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:21797140A>T	ENST00000318220.6	+	7	1239	c.191A>T	c.(190-192)aAa>aTa	p.K64I	NBPF3_ENST00000454000.2_Missense_Mutation_p.K50I|NBPF3_ENST00000342104.5_Missense_Mutation_p.K120I|NBPF3_ENST00000318249.5_Missense_Mutation_p.K120I			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	120						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAAGACTGCAAAGACCTCATA	0.557000													11	59					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162799314	162799314	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:162799314G>T	ENST00000375514.5	+	16	2240	c.1953G>T	c.(1951-1953)gtG>gtT	p.V651V	SLC4A10_ENST00000415876.2_Silent_p.V640V|SLC4A10_ENST00000421911.1_Silent_p.V670V|SLC4A10_ENST00000446997.1_Silent_p.V670V|SLC4A10_ENST00000272716.5_Silent_p.V640V	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	670					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GTAACTGTGTGGAACCGCATA	0.403000													11	5					2.27111e-07	2.69454e-07	1	1	0
NEK11	79858	broad.mit.edu	37	3	130799425	130799425	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:130799425A>G	ENST00000383366.4	+	4	622	c.329A>G	c.(328-330)tAc>tGc	p.Y110C	NEK11_ENST00000510688.1_Missense_Mutation_p.Y110C|NEK11_ENST00000356918.4_Missense_Mutation_p.Y110C|NEK11_ENST00000429253.2_Missense_Mutation_p.Y110C|NEK11_ENST00000412440.2_Intron|NEK11_ENST00000510769.1_Missense_Mutation_p.Y110C|NEK11_ENST00000508196.1_Missense_Mutation_p.Y110C|NEK11_ENST00000511262.1_Missense_Mutation_p.Y110C|NEK11_ENST00000507910.1_Missense_Mutation_p.Y110C	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	110	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						ATCACGGAGTACTGTGAGGTG	0.408000													7	44					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74407141	74407141	+	Silent	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:74407141A>T	ENST00000437994.2	+	2	524	c.93A>T	c.(91-93)acA>acT	p.T31T	CD109_ENST00000422508.2_Silent_p.T31T|CD109_ENST00000287097.5_Silent_p.T31T	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	31						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCTGGTGACAGCCCCAGGGA	0.507000													53	58					0	0	1	0	0
CTDSP1	58190	broad.mit.edu	37	2	219267782	219267782	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:219267782G>T	ENST00000273062.2	+	5	739	c.403G>T	c.(403-405)Gtg>Ttg	p.V135L	CTDSP1_ENST00000488627.1_3'UTR|CTDSP1_ENST00000443891.1_Missense_Mutation_p.V134L	NM_021198.2|NM_182642.2	NP_067021.1|NP_872580.1	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	135	FCP1 homology.				protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			NS(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	8		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGTCCTCACGTGGATGAGTT	0.672000													34	18					6.97489e-18	1.0672e-17	1	1	0
TRBV7-4	28594	broad.mit.edu	37	7	142176440	142176440	+	RNA	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142176440C>G	ENST00000390369.2	-	0	235																											ACCACTGGGCCGCCCTGATTT	0.567000													11	73					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616057	79616057	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:79616057C>T	ENST00000296739.4	+	1	268	c.23C>T	c.(22-24)gCt>gTt	p.A8V		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		GCTAAGTCAGCTGAGATGCCC	0.468000													61	151					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113504765	113504765	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:113504765C>G	ENST00000297405.5	-	31	5475	c.5231G>C	c.(5230-5232)gGa>gCa	p.G1744A	CSMD3_ENST00000455883.2_Missense_Mutation_p.G1640A|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1744A|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1704A	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1744	Sushi 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCCATCATCTCCCATGATACA	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			43	235					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145567970	145567970	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:145567970T>C	ENST00000296575.3	+	1	798	c.143T>C	c.(142-144)cTg>cCg	p.L48P	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.L48P	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	48	Arg-rich.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CCGAAGCGCCTGAAAAGGAGA	0.592000													12	39					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107977503	107977503	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:107977503G>T	ENST00000372129.2	-	1	2148	c.2072C>A	c.(2071-2073)gCt>gAt	p.A691D		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	691	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						TTCATCAAAAGCTCTGGCTCT	0.507000													156	145					1.70252e-45	3.35708e-45	1	1	0
EPHA4	2043	broad.mit.edu	37	2	222301267	222301267	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:222301267C>A	ENST00000281821.2	-	13	2239	c.2198G>T	c.(2197-2199)gGg>gTg	p.G733V	EPHA4_ENST00000409854.1_Missense_Mutation_p.G733V|EPHA4_ENST00000392071.4_Missense_Mutation_p.G682V|EPHA4_ENST00000409938.1_Missense_Mutation_p.G733V	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	733	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		ATACTTCATCCCAGACCCAAT	0.453000													50	36					2.74695e-27	4.86802e-27	1	1	0
PEX5L	51555	broad.mit.edu	37	3	179615952	179615952	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:179615952G>T	ENST00000467460.1	-	3	506	c.176C>A	c.(175-177)cCc>cAc	p.P59H	PEX5L_ENST00000476138.1_Missense_Mutation_p.P16H|PEX5L_ENST00000263962.8_Missense_Mutation_p.P57H|PEX5L_ENST00000472994.1_Intron|PEX5L_ENST00000468741.1_Intron|PEX5L_ENST00000465751.1_Missense_Mutation_p.P35H|PEX5L_ENST00000464614.1_Missense_Mutation_p.P16H|PEX5L_ENST00000392649.3_Missense_Mutation_p.P16H|PEX5L_ENST00000485199.1_Intron	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	59					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AGTAAGGAGGGGCTTTTCTTC	0.438000													48	115					1.17475e-09	1.47945e-09	1	1	0
FLJ33360	401172	broad.mit.edu	37	5	6337373	6337373	+	RNA	SNP	C	C	A	rs145072187	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:6337373C>A	ENST00000507444.1	-	0	32					NR_028351.1																						ACTTACGGCCCCCAGCAGAGA	0.542000													28	52					8.24728e-16	1.21326e-15	1	1	0
GYLTL1B	120071	broad.mit.edu	37	11	45948932	45948932	+	Silent	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:45948932A>C	ENST00000531526.1	+	11	1503	c.1392A>C	c.(1390-1392)acA>acC	p.T464T	GYLTL1B_ENST00000389968.3_Silent_p.T191T|GYLTL1B_ENST00000536139.1_Silent_p.T433T|GYLTL1B_ENST00000401752.1_Silent_p.T464T|GYLTL1B_ENST00000325468.5_Silent_p.T464T|GYLTL1B_ENST00000529052.1_Silent_p.T433T	NM_152312.3	NP_689525.3	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	464					muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(35;0.226)		TGTACCTGACAGACGCAGAAG	0.637000													13	37					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131234703	131234703	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:131234703G>T	ENST00000298542.4	-	2	274	c.99C>A	c.(97-99)agC>agA	p.S33R	RP1-305B16.2_ENST00000513703.1_RNA|FRMD7_ENST00000464296.1_Missense_Mutation_p.S33R	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	33	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					GATTTAGATGGCTGCAACTCA	0.378000													56	47					2.37494e-14	3.35286e-14	1	1	0
SETX	23064	broad.mit.edu	37	9	135139862	135139862	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:135139862G>A	ENST00000372169.2	-	27	8067	c.7885C>T	c.(7885-7887)Cac>Tac	p.H2629Y	SETX_ENST00000224140.5_Missense_Mutation_p.H2600Y|SETX_ENST00000393220.1_Missense_Mutation_p.H2567Y|SETX_ENST00000477049.1_5'UTR			Q7Z333	SETX_HUMAN	senataxin	2600					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GGAGGTTTGTGGCTGCTCAGA	0.622000													40	84					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108771	75108771	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:75108771C>G	ENST00000326665.5	-	4	473	c.255G>C	c.(253-255)caG>caC	p.Q85H		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	85										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTATTTCAAGCTGATGGTAAC	0.333000													12	58					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30774447	30774447	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:30774447G>T	ENST00000324685.6	+	3	576	c.141G>T	c.(139-141)atG>atT	p.M47I	RNF40_ENST00000402121.3_Missense_Mutation_p.M47I|RNF40_ENST00000357890.5_Missense_Mutation_p.M47I|RNF40_ENST00000563683.1_Missense_Mutation_p.M47I	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	47					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			AGGAGGAGATGGACCTGAAGG	0.512000													17	68					0.000566183	0.000608955	1	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27835112	27835112	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:27835112T>C	ENST00000331442.3	-	1	247	c.196A>G	c.(196-198)Aag>Gag	p.K66E		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	66	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						AAGGCCTTCTTAAGGGCTGCC	0.592000													73	100					0	0	1	0	0
DENND1B	163486	broad.mit.edu	37	1	197552327	197552327	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:197552327C>A	ENST00000235453.4	-	15	1291	c.1014G>T	c.(1012-1014)atG>atT	p.M338I	DENND1B_ENST00000367396.3_Missense_Mutation_p.M368I|DENND1B_ENST00000400967.2_Missense_Mutation_p.M338I			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	368	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						GGAACTGTTTCATCACGCTTG	0.398000													19	102					3.8784e-16	5.74578e-16	1	1	0
TTN	7273	broad.mit.edu	37	2	179594871	179594871	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:179594871G>T	ENST00000589042.1	-	62	18480	c.18256C>A	c.(18256-18258)Cta>Ata	p.L6086I	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.L5769I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.L4842I|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5769	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATTGCTTAGTTGGCAAATG	0.473000													17	28					1.5739e-10	2.03083e-10	1	1	0
PRSS58	136541	broad.mit.edu	37	7	141954911	141954911	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:141954911A>T	ENST00000552471.1	-	3	719	c.400T>A	c.(400-402)Tct>Act	p.S134T	PRSS58_ENST00000547058.2_Missense_Mutation_p.S134T			Q8IYP2	PRS58_HUMAN	protease, serine, 58	134	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						GTAGAGACAGAGCACATGGTA	0.423000													42	200					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168481	142168481	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142168481G>T	ENST00000454561.2	-	0	442																											TGAGAATCTAGGAGGGAAGTT	0.522000													24	84					6.84511e-11	8.90076e-11	1	1	0
PLCG2	5336	broad.mit.edu	37	16	81944140	81944140	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:81944140C>G	ENST00000359376.3	+	18	1963	c.1749C>G	c.(1747-1749)gtC>gtG	p.V583V		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	583	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						CAGGCCGGGTCCAGCACTGCC	0.632000													51	78					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149547	34149547	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:34149547C>A	ENST00000346193.3	-	1	900	c.849G>T	c.(847-849)cgG>cgT	p.R283R		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	283										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TTGTCTTCTCCCGGCCCTCAC	0.577000													32	16					1.88708e-17	2.88209e-17	1	1	0
PIPSL	266971	broad.mit.edu	37	10	95720270	95720270	+	RNA	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:95720270A>G	ENST00000480546.1	-	0	1027					NR_002319.2																						TCGAGTATCAACTGAGTATTG	0.493000													10	50					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900794	112900794	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:112900794C>T	ENST00000374530.3	+	8	3150	c.2970C>T	c.(2968-2970)tcC>tcT	p.S990S	AKAP2_ENST00000434623.2_Silent_p.S848S|AKAP2_ENST00000555236.1_Silent_p.S990S|AKAP2_ENST00000510514.5_Silent_p.S990S|AKAP2_ENST00000374525.1_Silent_p.S848S|AKAP2_ENST00000259318.7_Silent_p.S759S|PALM2-AKAP2_ENST00000302798.7_Silent_p.S990S|AKAP2_ENST00000482335.1_3'UTR	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		759							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						CACTGCCCTCCAGAACATGCT	0.522000													17	40					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79347994	79347994	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:79347994C>A	ENST00000233735.1	+	2	110	c.7C>A	c.(7-9)Cag>Aag	p.Q3K		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	3					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						CAGCATGGCTCAGACCAGCTC	0.468000													23	30					3.62473e-10	4.60632e-10	1	1	0
ATP8B4	79895	broad.mit.edu	37	15	50171572	50171572	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:50171572C>A	ENST00000284509.6	-	24	2923		c.e24+1		ATP8B4_ENST00000559829.1_Splice_Site	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.?(1)		breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AAAAAACATACCTGGTCAAAA	0.343000													36	15					1.04594e-18	1.62702e-18	1	1	0
NCOA1	8648	broad.mit.edu	37	2	24929831	24929831	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:24929831G>A	ENST00000405141.1	+	14	2203	c.1492G>A	c.(1492-1494)Gca>Aca	p.A498T	NCOA1_ENST00000395856.3_Missense_Mutation_p.A498T|NCOA1_ENST00000407230.1_Missense_Mutation_p.A347T|NCOA1_ENST00000406961.1_Missense_Mutation_p.A498T|NCOA1_ENST00000538539.1_Missense_Mutation_p.A498T|NCOA1_ENST00000288599.5_Missense_Mutation_p.A498T|NCOA1_ENST00000348332.3_Missense_Mutation_p.A498T			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	498	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTGGATTGGCAACAAGGCC	0.428000			T	PAX3	alveolar rhadomyosarcoma								72	52					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40854026	40854026	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:40854026G>T	ENST00000255224.3	-	2	736	c.368C>A	c.(367-369)cCg>cAg	p.P123Q	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Missense_Mutation_p.P105Q	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	123						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						AAAGAGCTTCGGGGTTGCATT	0.433000													33	127					1.45844e-13	2.04181e-13	1	1	0
TRPA1	8989	broad.mit.edu	37	8	72951100	72951100	+	Splice_Site	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:72951100C>G	ENST00000262209.4	-	19	2502	c.2295_splice	c.e19+1	p.T765_splice	RP11-383H13.1_ENST00000537896.1_Intron|TRPA1_ENST00000519720.1_5'UTR|RP11-383H13.1_ENST00000457356.4_Intron|RP11-383H13.1_ENST00000524152.1_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	765						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TTGAAATTACCGTGGTATCTA	0.294000													15	154					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166740437	166740437	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:166740437G>A	ENST00000243344.7	-	26	3688	c.3551C>T	c.(3550-3552)gCg>gTg	p.A1184V	TTC21B_ENST00000536175.1_Missense_Mutation_p.A122V	NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1184						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						ATTCATTTTCGCAATACGCTT	0.418000													69	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056773	9056773	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:9056773C>A	ENST00000397910.4	-	3	30876	c.30673G>T	c.(30673-30675)Gtg>Ttg	p.V10225L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10227	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTATGTCCACTGGAATTTCA	0.453000													33	36					4.02929e-09	4.99204e-09	1	1	0
NBEA	26960	broad.mit.edu	37	13	35683457	35683457	+	Silent	SNP	C	C	T	rs5011296		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:35683457C>T	ENST00000400445.3	+	12	2245	c.1711C>T	c.(1711-1713)Ctg>Ttg	p.L571L	NBEA_ENST00000379939.2_Silent_p.L571L|NBEA_ENST00000310336.4_Silent_p.L571L|NBEA_ENST00000540320.1_Silent_p.L571L	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	571						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TAGAGCTGTCCTGGAGCAATT	0.338000													27	31					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49259514	49259514	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:49259514G>T	ENST00000593756.1	+	2	593	c.21G>T	c.(19-21)ggG>ggT	p.G7G	FGF21_ENST00000222157.3_Silent_p.G7G			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	7					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ACGAGACCGGGTTCGAGCACT	0.592000													11	14					3.07112e-06	3.53389e-06	1	1	0
MYH2	4620	broad.mit.edu	37	17	10432950	10432950	+	Silent	SNP	C	C	T	rs145796634	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:10432950C>T	ENST00000245503.5	-	24	3432	c.3048G>A	c.(3046-3048)ctG>ctA	p.L1016L	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Silent_p.L1016L|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1016					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CCTCTGCCTGCAGGTCATCCA	0.483000													40	140					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8526626	8526626	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:8526626C>A	ENST00000381196.4	-	14	1112		c.e14+1		PTPRD_ENST00000358503.5_Intron|PTPRD_ENST00000397611.3_Splice_Site|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000486161.1_Splice_Site|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000540109.1_Splice_Site|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000355233.5_Splice_Site|PTPRD_ENST00000356435.5_Splice_Site|PTPRD_ENST00000360074.4_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGCACTCTTACCTCTTATTGG	0.413000										TSP Lung(15;0.13)			19	57					6.33239e-15	9.10823e-15	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152671408	152671408	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:152671408T>C	ENST00000367255.5	-	72	12397	c.11796A>G	c.(11794-11796)caA>caG	p.Q3932Q	SYNE1_ENST00000265368.4_Silent_p.Q3932Q|SYNE1_ENST00000341594.5_Silent_p.Q3856Q|SYNE1_ENST00000448038.1_Intron|SYNE1_ENST00000423061.1_Intron	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3932					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTCGACCTCTTGGAGCTCAC	0.527000										HNSCC(10;0.0054)			29	29					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945232	27945232	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:27945232G>A	ENST00000299340.4	-	1	371	c.28C>T	c.(28-30)Cca>Tca	p.P10S	CYYR1_ENST00000435845.2_Missense_Mutation_p.P118S|CYYR1_ENST00000400043.3_Missense_Mutation_p.P10S	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	10						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						AAGACCCCTGGACGCACGGGT	0.662000													16	71					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286092	130286092	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:130286092G>T	ENST00000257359.6	-	4	1936	c.1230C>A	c.(1228-1230)gcC>gcA	p.A410A		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	410	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TGAGATACATGGCGCTGCAGG	0.677000													7	5					1.26484e-09	1.59052e-09	1	1	0
PPIA	5478	broad.mit.edu	37	7	44838863	44838863	+	Silent	SNP	C	C	T	rs142406481	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:44838863C>T	ENST00000468812.1	+	2	132	c.87C>T	c.(85-87)gtC>gtT	p.V29V	PPIA_ENST00000480603.1_3'UTR|PPIA_ENST00000355968.6_5'UTR|PPIA_ENST00000489459.1_5'UTR|PPIA_ENST00000451562.1_Silent_p.V29V	NM_021130.3	NP_066953.1	P62937	PPIA_HUMAN	peptidylprolyl isomerase A (cyclophilin A)	29	PPIase cyclophilin-type.				entry into host cell|leukocyte migration|platelet activation|platelet degranulation|protein folding|provirus integration|regulation of viral genome replication|RNA-dependent DNA replication|uncoating of virus	cytosol|extracellular region|nucleus	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding|virion binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Cyclosporine(DB00091)|L-Proline(DB00172)	CAGACAAGGTCCCAAAGACAG	0.343000													34	68					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172065050	172065050	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:172065050G>T	ENST00000336824.4	+	21	2512	c.2413G>T	c.(2413-2415)Gga>Tga	p.G805*	FNDC3B_ENST00000416957.1_Nonsense_Mutation_p.G805*|FNDC3B_ENST00000415807.2_Nonsense_Mutation_p.G805*	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	805	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GTTGGAATGGGGAGAAGATGA	0.433000													20	186					2.37509e-13	3.30311e-13	1	1	0
COLGALT2	23127	broad.mit.edu	37	1	183908086	183908086	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:183908086C>A	ENST00000361927.4	-	12	2061	c.1690G>T	c.(1690-1692)Ggc>Tgc	p.G564C	COLGALT2_ENST00000367520.3_Missense_Mutation_p.G301C|COLGALT2_ENST00000367521.1_Missense_Mutation_p.G172C|COLGALT2_ENST00000546159.1_Intron|COLGALT2_ENST00000486375.1_Intron	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CCCGGCTGGCCTGTGTAGTGC	0.547000													23	69					3.5997e-14	5.0649e-14	1	1	0
ZAN	7455	broad.mit.edu	37	7	100365576	100365576	+	RNA	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:100365576C>G	ENST00000542585.1	+	0	5131				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACGACGGGAGCCACTTGGTGG	0.597000													7	30					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50918212	50918212	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:50918212C>A	ENST00000442544.2	+	17	3259	c.2643C>A	c.(2641-2643)taC>taA	p.Y881*	DCC_ENST00000412726.1_Nonsense_Mutation_p.Y709*|DCC_ENST00000581580.1_Nonsense_Mutation_p.Y516*	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	881	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCGACTTTACACCGTCCGGT	0.448000													32	52					1.74807e-11	2.30515e-11	1	1	0
NLRP3	114548	broad.mit.edu	37	1	247607989	247607989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:247607989G>A	ENST00000366497.2	+	8	3486	c.2706G>A	c.(2704-2706)tgG>tgA	p.W902*	NLRP3_ENST00000348069.2_Nonsense_Mutation_p.W845*|NLRP3_ENST00000366496.2_Nonsense_Mutation_p.W902*|NLRP3_ENST00000391828.3_Nonsense_Mutation_p.W959*|NLRP3_ENST00000336119.3_Nonsense_Mutation_p.W959*|NLRP3_ENST00000391827.2_Nonsense_Mutation_p.W902*	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	959					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACTGCTGCTGGGATCTTTCCA	0.522000													11	74					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6175041	6175041	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:6175041G>T	ENST00000264870.3	-	12	1784	c.1519C>A	c.(1519-1521)Ctc>Atc	p.L507I		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	507					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCTGTGTTGAGGGGCTTTTTA	0.458000													29	51					4.4194e-11	5.7734e-11	1	1	0
OR5D16	390144	broad.mit.edu	37	11	55607148	55607148	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:55607148C>A	ENST00000378396.1	+	1	921	c.921C>A	c.(919-921)atC>atA	p.I307I		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GAAAAATAATCAATACAAAAT	0.328000													9	41					0.000274275	0.000297663	1	1	0
PRPS1	5631	broad.mit.edu	37	X	106884134	106884134	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:106884134C>A	ENST00000372435.4	+	3	431	c.309C>A	c.(307-309)agC>agA	p.S103R	PRPS1_ENST00000372418.1_Intron|PRPS1_ENST00000372428.4_Missense_Mutation_p.S36R|PRPS1_ENST00000543248.1_Missense_Mutation_p.S103R|PRPS1_ENST00000372419.3_Missense_Mutation_p.S103R	NM_002764.3	NP_002755.1	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	103					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	23						CCATTTAGAGCCGGGCGCCAA	0.378000													63	75					6.77243e-49	1.34807e-48	1	1	0
CPEB1	64506	broad.mit.edu	37	15	83221240	83221240	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:83221240C>A	ENST00000563800.1	-	8	2996	c.1271G>T	c.(1270-1272)cGc>cTc	p.R424L	CPEB1_ENST00000562019.1_Missense_Mutation_p.R402L|CPEB1_ENST00000261723.6_Missense_Mutation_p.R400L|CPEB1_ENST00000450751.2_Missense_Mutation_p.R322L|CPEB1_ENST00000568757.1_Missense_Mutation_p.R322L|CPEB1_ENST00000423133.2_Missense_Mutation_p.R322L|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000568128.1_Missense_Mutation_p.R397L|CPEB1_ENST00000398591.2_Missense_Mutation_p.R327L|CPEB1_ENST00000398592.2_Missense_Mutation_p.R171L|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.A132S|CPEB1_ENST00000564522.1_Missense_Mutation_p.R322L			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	402	Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			CTCCTTGCAGCGCATCCTTCG	0.517000													15	34					0.000308642	0.000334097	1	1	0
CR1	1378	broad.mit.edu	37	1	207751383	207751383	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:207751383C>A	ENST00000367049.4	+	29	4771	c.4771C>A	c.(4771-4773)Cca>Aca	p.P1591T	CR1_ENST00000367051.1_Missense_Mutation_p.P1141T|RP11-78B10.2_ENST00000597497.1_RNA|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000400960.2_Missense_Mutation_p.P1141T|CR1_ENST00000367052.1_Missense_Mutation_p.P1141T|CR1_ENST00000367053.1_Missense_Mutation_p.P1141T	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1141	Sushi 25.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ATGCACGCCTCCAAATGTGGA	0.473000													39	171					9.40368e-32	1.72847e-31	1	1	0
NME8	51314	broad.mit.edu	37	7	37896883	37896883	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:37896883C>A	ENST00000199447.4	+	6	578	c.206C>A	c.(205-207)gCt>gAt	p.A69D	NME8_ENST00000440017.1_Missense_Mutation_p.A69D|EPDR1_ENST00000476620.1_5'UTR	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	69	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										CAGGCAGAAGCTGACAACATT	0.274000													17	58					6.49762e-13	8.8748e-13	1	1	0
CR1	1378	broad.mit.edu	37	1	207751384	207751384	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:207751384C>A	ENST00000367049.4	+	29	4772	c.4772C>A	c.(4771-4773)cCa>cAa	p.P1591Q	CR1_ENST00000367051.1_Missense_Mutation_p.P1141Q|RP11-78B10.2_ENST00000597497.1_RNA|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000400960.2_Missense_Mutation_p.P1141Q|CR1_ENST00000367052.1_Missense_Mutation_p.P1141Q|CR1_ENST00000367053.1_Missense_Mutation_p.P1141Q	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1141	Sushi 25.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TGCACGCCTCCAAATGTGGAA	0.473000													39	172					9.40368e-32	1.72847e-31	1	1	0
FCRL1	115350	broad.mit.edu	37	1	157771821	157771821	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:157771821C>A	ENST00000358292.3	-	5	821	c.770G>T	c.(769-771)gGa>gTa	p.G257V	FCRL1_ENST00000368176.3_Missense_Mutation_p.G257V|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.G257V	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	257	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGCTCCTCCTCCAGAGGGGGC	0.592000													57	81					6.176e-18	9.46685e-18	1	1	0
TET2	54790	broad.mit.edu	37	4	106157960	106157960	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:106157960G>C	ENST00000513237.1	+	3	3721	c.2924G>C	c.(2923-2925)tGg>tCg	p.W975S	TET2_ENST00000305737.2_Missense_Mutation_p.W954S|TET2_ENST00000380013.4_Missense_Mutation_p.W954S|TET2_ENST00000413648.2_Missense_Mutation_p.W954S|TET2_ENST00000545826.1_Missense_Mutation_p.W954S|TET2_ENST00000394764.1_Missense_Mutation_p.W954S|TET2_ENST00000540549.1_Missense_Mutation_p.W954S			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	954					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.A950fs*15(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GCTCTAAGGTGGCATCTCTTA	0.493000			"""Mis N, F"""		MDS								19	36					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112392	248112392	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248112392C>A	ENST00000357191.3	+	1	233	c.233C>A	c.(232-234)cCt>cAt	p.P78H	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACCATTGTTCCTAAGATGGCA	0.443000													120	599					4.73232e-52	9.46465e-52	1	1	0
DBNDD2	55861	broad.mit.edu	37	20	44036992	44036992	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:44036992G>T	ENST00000372720.3	+	2	410	c.179G>T	c.(178-180)gGg>gTg	p.G60V	SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|DBNDD2_ENST00000360981.4_Intron|DBNDD2_ENST00000357275.2_Intron|DBNDD2_ENST00000372723.3_Intron|DBNDD2_ENST00000372722.3_Intron|DBNDD2_ENST00000372717.1_Intron|DBNDD2_ENST00000372712.2_Intron|DBNDD2_ENST00000372710.3_Missense_Mutation_p.G64V	NM_018478.3	NP_060948.3	Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	60					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CCGGAGCCAGGGGCCCCACTG	0.597000													19	10					5.03518e-11	6.56763e-11	1	1	0
LPHN3	23284	broad.mit.edu	37	4	62849274	62849274	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:62849274G>T	ENST00000512091.1	+	18	3732	c.2985G>T	c.(2983-2985)gtG>gtT	p.V995V	LPHN3_ENST00000507164.1_Silent_p.V1063V|LPHN3_ENST00000508946.1_Silent_p.V995V|LPHN3_ENST00000511324.1_Silent_p.V1063V|LPHN3_ENST00000507625.1_Silent_p.V1063V|LPHN3_ENST00000504896.1_Silent_p.V995V|LPHN3_ENST00000514996.1_Silent_p.V995V|LPHN3_ENST00000506746.1_Silent_p.V1063V|LPHN3_ENST00000514157.1_Silent_p.V995V|LPHN3_ENST00000508693.1_Silent_p.V1063V|LPHN3_ENST00000506720.1_Silent_p.V1063V|LPHN3_ENST00000509896.1_Silent_p.V1063V|LPHN3_ENST00000506700.1_Silent_p.V995V|LPHN3_ENST00000545650.1_Silent_p.V995V|LPHN3_ENST00000514591.1_Silent_p.V995V			Q9HAR2	LPHN3_HUMAN	latrophilin 3	982					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CACTCATTGTGGCTGTGTCAG	0.398000													28	112					1.55811e-20	2.48352e-20	1	1	0
FANCB	2187	broad.mit.edu	37	X	14882881	14882881	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:14882881T>A	ENST00000398334.1	-	3	1019	c.752A>T	c.(751-753)cAg>cTg	p.Q251L	FANCB_ENST00000324138.3_Missense_Mutation_p.Q251L	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	251					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					TATTCTTAACTGGTTTTTGAT	0.368000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				39	94					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170201230	170201230	+	Missense_Mutation	SNP	C	C	A	rs2276717	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:170201230C>A	ENST00000231706.4	-	6	1303	c.988G>T	c.(988-990)Ggg>Tgg	p.G330W	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	330			G -> R (in dbSNP:rs2276717).			integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GCATAGAACCCATGAGCCACA	0.498000											OREG0015917	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	69	141					8.3131e-28	1.49529e-27	1	1	0
CRB1	23418	broad.mit.edu	37	1	197391015	197391015	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:197391015G>C	ENST00000367397.1	+	2	1058	c.200G>C	c.(199-201)cGc>cCc	p.R67P	CRB1_ENST00000367399.2_Missense_Mutation_p.R574P|CRB1_ENST00000543483.1_3'UTR|CRB1_ENST00000544212.1_Missense_Mutation_p.R167P|CRB1_ENST00000535699.1_Missense_Mutation_p.R617P|CRB1_ENST00000367400.3_Missense_Mutation_p.R686P|CRB1_ENST00000538660.1_Missense_Mutation_p.R686P			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	686	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGCAGAGGACGCTGCATCAAC	0.507000													44	84					0	0	1	0	0
NEU1	4758	broad.mit.edu	37	6	31827583	31827583	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:31827583G>T	ENST00000375631.4	-	6	1290	c.1161C>A	c.(1159-1161)ccC>ccA	p.P387P		NM_000434.3	NP_000425.1	Q99519	NEUR1_HUMAN	sialidase 1 (lysosomal sialidase)	387						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10					Oseltamivir(DB00198)|Zanamivir(DB00558)	CGTAGAGCTGGGGGGCCTGCT	0.587000													10	168					2.17888e-05	2.43709e-05	1	1	0
FAT2	2196	broad.mit.edu	37	5	150924311	150924311	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:150924311G>A	ENST00000261800.5	-	9	6389	c.6377C>T	c.(6376-6378)tCa>tTa	p.S2126L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2126	Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCTTGAGTGATATGTCCCC	0.433000													36	195					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210334347	210334347	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:210334347G>T	ENST00000537238.1	+	9	1905	c.1514G>T	c.(1513-1515)gGa>gTa	p.G505V	SYT14_ENST00000367019.1_Missense_Mutation_p.G562V|SYT14_ENST00000367015.1_Missense_Mutation_p.G505V|SYT14_ENST00000534859.1_Missense_Mutation_p.G569V|SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000472886.1_Missense_Mutation_p.G543V|SYT14_ENST00000422431.1_Missense_Mutation_p.G607V|SYT14_ENST00000399639.2_3'UTR	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	543	C2 2.					integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GAGTCAAAAGGACAGCAAGTA	0.393000													47	97					1.19451e-25	2.08605e-25	1	1	0
HRNR	388697	broad.mit.edu	37	1	152188358	152188358	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:152188358C>A	ENST00000368801.2	-	3	5822	c.5747G>T	c.(5746-5748)aGc>aTc	p.S1916I	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1916					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAACCTGAGCTAGATCCGTG	0.562000													228	3421					3.76997e-23	6.29577e-23	1	1	0
HHIPL1	84439	broad.mit.edu	37	14	100118961	100118961	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:100118961G>T	ENST00000330710.5	+	2	754	c.656G>T	c.(655-657)tGg>tTg	p.W219L	HHIPL1_ENST00000357223.2_Missense_Mutation_p.W219L	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	219					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				GGGCTGGTGTGGGCCTACCTG	0.687000													33	15					1.08312e-15	1.5823e-15	1	1	0
CHORDC1	26973	broad.mit.edu	37	11	89936557	89936557	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:89936557C>A	ENST00000529726.1	-	2	4057	c.144G>T	c.(142-144)caG>caT	p.Q48H	CHORDC1_ENST00000457199.2_Missense_Mutation_p.Q217H|CHORDC1_ENST00000529987.1_Missense_Mutation_p.Q48H|CHORDC1_ENST00000320585.6_Missense_Mutation_p.Q236H			Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain (CHORD) containing 1	236	CHORD 1.|Interaction with PPP5C (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding			endometrium(2)|large_intestine(2)|liver(1)|lung(6)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				CACCTCCAGTCTGATGCCAGT	0.343000													45	165					1.48646e-12	2.02371e-12	1	1	0
JUNB	3726	broad.mit.edu	37	19	12902819	12902819	+	Silent	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:12902819G>C	ENST00000302754.4	+	1	510	c.234G>C	c.(232-234)gcG>gcC	p.A78A		NM_002229.2	NP_002220.1	P17275	JUNB_HUMAN	jun B proto-oncogene	78						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|kidney(1)|lung(3)	6						ACACCGGCGCGTCTCTCAAGC	0.657000													13	3					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100433439	100433439	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:100433439C>A	ENST00000279907.7	-	20	4422	c.4210G>T	c.(4210-4212)Ggg>Tgg	p.G1404W	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.G1054W	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1404										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						CAAGGAACCCCTGGGCTTGTC	0.458000													25	65					7.92952e-12	1.06064e-11	1	1	0
VCAN	1462	broad.mit.edu	37	5	82816596	82816596	+	Nonsense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:82816596C>G	ENST00000265077.3	+	7	3036	c.2471C>G	c.(2470-2472)tCa>tGa	p.S824*	VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Nonsense_Mutation_p.S824*|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Nonsense_Mutation_p.S776*	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	824	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCAGCCTCTTCAAAATTGCCC	0.413000													37	66					0	0	1	0	0
ONECUT1	3175	broad.mit.edu	37	15	53081196	53081196	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:53081196C>G	ENST00000305901.5	-	1	1013	c.886G>C	c.(886-888)Gag>Cag	p.E296Q	ONECUT1_ENST00000561401.2_Intron	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	296					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		TGCGCCACCTCTTTGGTATTG	0.622000													27	75					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64683267	64683267	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:64683267G>A	ENST00000413366.3	+	6	594	c.568G>A	c.(568-570)Ggg>Agg	p.G190R		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	190	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding	p.G190W(1)		breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GGATCCAAACGGGCTTTCAGA	0.408000													33	111					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32955581	32955581	+	Splice_Site	SNP	G	G	C	rs35805309		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:32955581G>C	ENST00000321639.5	+	4	1056		c.e4-1			NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E							integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CTTTGTCCCAGGGTGAAGGCC	0.587000													17	22					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77762481	77762481	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:77762481G>A	ENST00000521891.2	+	9	4295	c.3846_splice	c.e9-1	p.V1283_splice	ZFHX4_ENST00000050961.6_Splice_Site_p.V1238_splice|ZFHX4_ENST00000455469.2_Splice_Site_p.V1238_splice|ZFHX4_ENST00000518282.1_Splice_Site_p.V1257_splice	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1238						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTTTCCAAAGGTGCCTGTCCC	0.473000										HNSCC(33;0.089)			7	38					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55085979	55085979	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:55085979G>T	ENST00000251377.3	+	4	415	c.282G>T	c.(280-282)cgG>cgT	p.R94R	LILRA2_ENST00000391737.1_Silent_p.R82R|LILRA2_ENST00000391738.3_Silent_p.R94R|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Silent_p.R94R|LILRA2_ENST00000495786.1_3'UTR|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACGCAGGGCGGTATCACTGTC	0.547000													70	40					7.07328e-35	1.32921e-34	1	1	0
PCDHGB4	8641	broad.mit.edu	37	5	140768418	140768418	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:140768418G>A	ENST00000519479.1	+	1	967	c.967G>A	c.(967-969)Gga>Aga	p.G323R	PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGGACGGTGGAGGAATGAT	0.398000													15	50					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96197084	96197084	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:96197084C>G	ENST00000324765.8	+	13	1740	c.1393C>G	c.(1393-1395)Cca>Gca	p.P465A	DIAPH2_ENST00000355827.4_Missense_Mutation_p.P465A|DIAPH2_ENST00000373049.4_Missense_Mutation_p.P465A|DIAPH2_ENST00000373061.3_Missense_Mutation_p.P465A|DIAPH2_ENST00000373054.4_Missense_Mutation_p.P461A			O60879	DIAP2_HUMAN	diaphanous-related formin 2	465					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						TGGTATGGATCCAGACTTCAA	0.373000													28	122					0	0	1	0	0
RFC5	5985	broad.mit.edu	37	12	118457468	118457468	+	Silent	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:118457468A>G	ENST00000392542.2	+	4	632	c.99A>G	c.(97-99)ccA>ccG	p.P33P	RFC5_ENST00000229043.3_5'UTR|RFC5_ENST00000454402.2_Silent_p.P54P	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	54					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCGACTGCCACACTTGCTTC	0.502000													80	83					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78636412	78636412	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:78636412C>T	ENST00000354212.4	-	2	665	c.412G>A	c.(412-414)Gtg>Atg	p.V138M	MAGI2_ENST00000522391.1_Missense_Mutation_p.V138M|MAGI2_ENST00000419488.1_Missense_Mutation_p.V138M	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	138	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCACATGGCACCGTGCGGAGG	0.368000													11	112					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72987567	72987567	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:72987567C>G	ENST00000262209.4	-	1	285	c.78G>C	c.(76-78)ccG>ccC	p.P26P		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	26						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CCGTGTCGTCCGGCACATCCT	0.632000													30	267					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47772743	47772743	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:47772743G>A	ENST00000263773.5	-	5	749	c.737C>T	c.(736-738)cCc>cTc	p.P246L	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	246	WW 1.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						AAGATATTGGGGTAACTCCCA	0.413000													32	98					0	0	1	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446903	29446903	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:29446903C>A	ENST00000544604.2	+	8	2909	c.2734C>A	c.(2734-2736)Cag>Aag	p.Q912K	ZNRF3_ENST00000402174.1_Missense_Mutation_p.Q812K|ZNRF3_ENST00000406323.3_Missense_Mutation_p.Q812K|ZNRF3_ENST00000332811.4_Missense_Mutation_p.Q812K	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	912						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						CCAGGACACTCAGGAGTCCAG	0.622000													5	24					0.184627	0.186179	1	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090195	238090195	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:238090195C>A	ENST00000450451.1	+	0	1701					NR_027247.2																						GCTGGCTTTGCTGGGGACGAT	0.602000													13	11					1.3612e-06	1.5793e-06	1	1	0
SMR3A	26952	broad.mit.edu	37	4	71232547	71232547	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:71232547C>A	ENST00000226460.4	+	3	337	c.241C>A	c.(241-243)Cct>Act	p.P81T		NM_012390.3	NP_036522.3	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3A	81	Poly-Pro.|Pro-rich.					extracellular region				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)	15		all_hematologic(202;0.196)				ACCATCCCCTCCTCCACCCTA	0.557000													34	132					1.836e-18	2.84546e-18	1	1	0
TRBV7-8	28590	broad.mit.edu	37	7	142099640	142099640	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142099640G>T	ENST00000390359.3	-	0	200																											GGGCCTGTTGGTACCAAAAAA	0.507000													13	54					4.3838e-07	5.12868e-07	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79320556	79320556	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:79320556G>T	ENST00000428286.1	-	8	6757	c.5557C>A	c.(5557-5559)Cca>Aca	p.P1853T	PRUNE2_ENST00000376718.3_Missense_Mutation_p.P2212T			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2212					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GCCATATCTGGGCTGGCTCCT	0.453000													31	69					3.03874e-20	4.82522e-20	1	1	0
TMEM189	387521	broad.mit.edu	37	20	48744631	48744631	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:48744631G>A	ENST00000557021.1	-	5	732	c.572C>T	c.(571-573)aCg>aTg	p.T191M	TMEM189-UBE2V1_ENST00000341698.2_Missense_Mutation_p.T191M|TMEM189_ENST00000371656.2_Missense_Mutation_p.T116M|TMEM189_ENST00000371650.5_Missense_Mutation_p.T188M|TMEM189_ENST00000371652.4_Missense_Mutation_p.T191M	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			CCCAAAGTACGTGTGCGACCA	0.592000													32	76					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038823	11038823	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:11038823G>T	ENST00000470054.1	-	0	1380									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAAGTTGTTGGCATGATGTT	0.458000													129	338					8.39346e-61	1.68672e-60	1	1	0
PCDHGA4	56111	broad.mit.edu	37	5	140735382	140735382	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:140735382G>T	ENST00000571252.1	+	1	615	c.615G>T	c.(613-615)gaG>gaT	p.E205D	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGGAAGAGGCGGTTCACC	0.542000													10	28					2.17888e-05	2.43709e-05	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141283880	141283880	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:141283880C>A	ENST00000389484.3	-	48	8773	c.7802G>T	c.(7801-7803)gGg>gTg	p.G2601V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2601	LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATACAAGTCCCATCTGCACA	0.418000										TSP Lung(27;0.18)			16	37					6.49762e-13	8.8748e-13	1	1	0
HGF	3082	broad.mit.edu	37	7	81334788	81334788	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:81334788C>A	ENST00000222390.5	-	17	2154	c.1928G>T	c.(1927-1929)aGc>aTc	p.S643I	HGF_ENST00000457544.2_Missense_Mutation_p.S638I	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	643	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						ATGATGCTGGCTGCATTTCTC	0.403000													27	67					1.2476e-16	1.87811e-16	1	1	0
HRH3	11255	broad.mit.edu	37	20	60793637	60793637	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:60793637C>A	ENST00000340177.5	-	2	611	c.327G>T	c.(325-327)ctG>ctT	p.L109L	HRH3_ENST00000317393.6_Silent_p.L109L	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	109					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CTACCAGCCACAGCTTGCAGA	0.627000													5	49					0.014758	0.0151549	1	1	0
SYT10	341359	broad.mit.edu	37	12	33559774	33559774	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:33559774C>A	ENST00000228567.3	-	3	1323	c.1027G>T	c.(1027-1029)Gat>Tat	p.D343Y	SYT10_ENST00000535526.1_Missense_Mutation_p.D162Y	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	343						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CTGGAGAGATCAGAGACTTCA	0.353000													61	77					3.57465e-26	6.28181e-26	1	1	0
SHCBP1L	81626	broad.mit.edu	37	1	182874672	182874672	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:182874672G>T	ENST00000367547.3	-	7	1531	c.1295C>A	c.(1294-1296)gCt>gAt	p.A432D	SHCBP1L_ENST00000488956.1_5'UTR|SHCBP1L_ENST00000423786.1_Missense_Mutation_p.A313D	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	504										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						AAGATTTGCAGCTTGATATTC	0.358000													28	89					1.5548e-18	2.41411e-18	1	1	0
WASF1	8936	broad.mit.edu	37	6	110429812	110429812	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:110429812C>A	ENST00000392589.1	-	6	1177	c.341G>T	c.(340-342)cGc>cTc	p.R114L	WASF1_ENST00000359451.2_Missense_Mutation_p.R114L|WASF1_ENST00000392587.2_Missense_Mutation_p.R114L|WASF1_ENST00000392586.1_Missense_Mutation_p.R114L|WASF1_ENST00000392588.1_Missense_Mutation_p.R114L	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	114					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CAAAGTCTTGCGATCGAAAAG	0.368000													58	34					4.32865e-36	8.28261e-36	1	1	0
CAMSAP2	23271	broad.mit.edu	37	1	200811142	200811142	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:200811142G>T	ENST00000358823.2	+	7	1218	c.948G>T	c.(946-948)atG>atT	p.M316I	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.M327I|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.M316I	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	327	CH.					cytoplasm|microtubule	protein binding										TGGTGTTCATGGCGGAACTGT	0.333000													13	111					0.00010058	0.000109581	1	1	0
RSAD1	55316	broad.mit.edu	37	17	48557272	48557272	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:48557272C>A	ENST00000258955.2	+	3	386	c.301C>A	c.(301-303)Ccc>Acc	p.P101T		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	101					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TGGGGGGACCCCCAGTCTAGC	0.612000											OREG0024566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	52					3.65163e-15	5.27946e-15	1	1	0
NDUFAF6	137682	broad.mit.edu	37	8	96060747	96060747	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:96060747A>G	ENST00000396113.1	+	13	1551	c.501A>G	c.(499-501)atA>atG	p.I167M	NDUFAF6_ENST00000396124.4_Missense_Mutation_p.I259M|NDUFAF6_ENST00000396111.2_Missense_Mutation_p.I167M|NDUFAF6_ENST00000542894.1_Missense_Mutation_p.I207M|NDUFAF6_ENST00000286687.4_Missense_Mutation_p.I107M			Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	259					biosynthetic process	mitochondrion	transferase activity										GAGATGTAATATATGACATTG	0.373000													27	171					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276832	186276832	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:186276832C>A	ENST00000445192.2	+	7	2026	c.1981C>A	c.(1981-1983)Cct>Act	p.P661T	PRG4_ENST00000367483.4_Missense_Mutation_p.P620T|PRG4_ENST00000367485.4_Missense_Mutation_p.P568T|PRG4_ENST00000367486.3_Missense_Mutation_p.P618T|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	661	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCCCTGAGGAGCC	0.667000													11	38					6.40141e-05	7.0382e-05	1	1	0
IDE	3416	broad.mit.edu	37	10	94264645	94264645	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:94264645G>C	ENST00000265986.6	-	11	1392	c.1336C>G	c.(1336-1338)Cta>Gta	p.L446V		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	446					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCTCTTCTAGGGGATAATAC	0.318000													15	38					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39791175	39791175	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:39791175C>A	ENST00000373272.2	+	5	1001	c.597_splice	c.e5+1	p.T199_splice	PLCG1_ENST00000244007.3_Splice_Site_p.T199_splice|PLCG1_ENST00000373271.1_Splice_Site_p.T199_splice	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	199					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				GAGCGGCTGACGGTAAGTGCC	0.592000													45	27					3.70713e-34	6.91998e-34	1	1	0
NUP133	55746	broad.mit.edu	37	1	229637784	229637784	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:229637784G>C	ENST00000261396.3	-	3	458	c.367C>G	c.(367-369)Ctc>Gtc	p.L123V	NUP133_ENST00000366679.1_Missense_Mutation_p.L123V|NUP133_ENST00000366678.3_Missense_Mutation_p.L123V|NUP133_ENST00000537506.1_Missense_Mutation_p.L107V	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	123					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CAAATAATGAGCTTCTCTTTG	0.403000													121	130					0	0	1	0	0
MLLT6	4302	broad.mit.edu	37	17	36874126	36874126	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:36874126G>T	ENST00000325718.7	+	12	1953	c.1862G>T	c.(1861-1863)aGc>aTc	p.S621I	CTB-58E17.9_ENST00000579499.1_RNA	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	621					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					TCTACCTTTAGCCTCCCTTCT	0.537000			T	MLL	AL								48	103					1.32667e-27	2.37107e-27	1	1	0
ASF1B	55723	broad.mit.edu	37	19	14247228	14247228	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:14247228T>A	ENST00000263382.3	-	1	540	c.41A>T	c.(40-42)aAc>aTc	p.N14I	ASF1B_ENST00000474890.1_Missense_Mutation_p.N14I|ASF1B_ENST00000592798.1_Missense_Mutation_p.N14I	NM_018154.2	NP_060624.1	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B histone chaperone	14	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus				endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7						AGGGCTCGGGTTCTCCAGGAC	0.716000													14	24					0	0	1	0	0
PF4V1	5197	broad.mit.edu	37	4	74719786	74719786	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:74719786G>T	ENST00000226524.3	+	3	436	c.262G>T	c.(262-264)Gat>Tat	p.D88Y		NM_002620.2	NP_002611.1	P10720	PF4V_HUMAN	platelet factor 4 variant 1	88					immune response	extracellular region	chemokine activity|heparin binding			endometrium(1)|liver(2)	3	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			AATTTGCTTGGATCTGCAAGC	0.448000													16	53					3.41278e-10	4.36338e-10	1	1	0
GAB4	128954	broad.mit.edu	37	22	17443639	17443639	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:17443639C>A	ENST00000400588.1	-	10	1816	c.1709G>T	c.(1708-1710)aGg>aTg	p.R570M		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	570										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				CTTGGCGCCCCTGGGAGGCTC	0.587000													12	42					3.07112e-06	3.53389e-06	1	1	0
CES1P1	51716	broad.mit.edu	37	16	55806374	55806374	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:55806374G>T	ENST00000571348.1	+	0	676					NR_003276.2																						GCTTTGGAGGGAACCCAGGCT	0.592000													6	20					8.12818e-05	8.8902e-05	1	1	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108971	90108971	+	RNA	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:90108971C>T	ENST00000390271.2	+	0	262																											TCAGGGGTCCCCTCGAGGTTC	0.498000													50	32					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97198180	97198180	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:97198180G>T	ENST00000389672.5	+	9	2084	c.2046G>T	c.(2044-2046)aaG>aaT	p.K682N	EPHA6_ENST00000502694.1_Missense_Mutation_p.K74N|EPHA6_ENST00000514100.1_Missense_Mutation_p.K74N|EPHA6_ENST00000442602.2_Missense_Mutation_p.K48N	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	587	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CAGAAGAGAAGAGAAGAAACC	0.338000													15	25					6.94344e-10	8.78387e-10	1	1	0
TCF4	6925	broad.mit.edu	37	18	52937195	52937195	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:52937195C>A	ENST00000354452.3	-	11	1401		c.e11-1		TCF4_ENST00000564403.2_Splice_Site|TCF4_ENST00000564228.1_Splice_Site|TCF4_ENST00000544241.2_Splice_Site|TCF4_ENST00000398339.1_Splice_Site|TCF4_ENST00000563760.1_Splice_Site|TCF4_ENST00000564999.1_Splice_Site|TCF4_ENST00000537578.1_Splice_Site|TCF4_ENST00000566279.1_Splice_Site|TCF4_ENST00000457482.3_Splice_Site|TCF4_ENST00000566286.1_Splice_Site|TCF4_ENST00000543082.1_Splice_Site|TCF4_ENST00000568740.1_Splice_Site|TCF4_ENST00000565018.2_Splice_Site|TCF4_ENST00000568673.1_Splice_Site|TCF4_ENST00000540999.1_Splice_Site|TCF4_ENST00000567880.1_Splice_Site|TCF4_ENST00000561992.1_Splice_Site|TCF4_ENST00000570287.2_Splice_Site|TCF4_ENST00000570177.2_Splice_Site|TCF4_ENST00000537856.3_Splice_Site|TCF4_ENST00000356073.4_Splice_Site|TCF4_ENST00000561831.3_Splice_Site	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4						positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		ATGGATAGCTCTATAGCAAGA	0.388000													23	71					1.85244e-09	2.32246e-09	1	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129575	248129575	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:248129575G>A	ENST00000366480.3	+	1	1041	c.942G>A	c.(940-942)ggG>ggA	p.G314G	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AAGTGACGGGGGCAGTGAGGA	0.428000													19	135					0	0	1	0	0
BEND2	139105	broad.mit.edu	37	X	18183169	18183169	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:18183169G>C	ENST00000380033.4	-	14	2492	c.2360C>G	c.(2359-2361)tCa>tGa	p.S787*		NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	787										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						TCCTGGCTTTGACTCCTGCTC	0.498000													45	127					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23823249	23823249	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:23823249G>A	ENST00000354639.3	+	17	2510	c.2046G>A	c.(2044-2046)ctG>ctA	p.L682L	STK31_ENST00000428484.1_Silent_p.L682L|STK31_ENST00000355870.3_Silent_p.L705L|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Silent_p.L705L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	705							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AGCTGCCTCTGCTTCATCCTG	0.318000													34	141					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121395775	121395775	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:121395775G>A	ENST00000393667.3	-	17	9252	c.9142C>T	c.(9142-9144)Caa>Taa	p.Q3048*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.Q3043*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	3043					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		AACTCCTTTTGGTGAATTTCC	0.418000													17	71					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99097648	99097648	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:99097648C>A	ENST00000337673.6	-	1	272	c.69G>T	c.(67-69)gcG>gcT	p.A23A	ZNF394_ENST00000426306.2_Silent_p.A23A|ZNF394_ENST00000394177.3_Intron|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	23					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CCTTGGACCTCGCAGCCATCA	0.632000													11	67					0.000978159	0.00103875	1	1	0
CYYR1	116159	broad.mit.edu	37	21	27945326	27945326	+	Silent	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:27945326A>T	ENST00000435845.2	-	1	277	c.258T>A	c.(256-258)ccT>ccA	p.P86P	CYYR1_ENST00000400043.3_5'UTR|CYYR1_ENST00000299340.4_5'UTR			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	129						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GGGAGGATGGAGGGCGATCAG	0.692000													5	24					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517185	158517185	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:158517185C>A	ENST00000302617.3	-	1	710	c.711G>T	c.(709-711)caG>caT	p.Q237H		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TTTGGCGGCCCTGAGCAGAAG	0.517000													57	125					7.36392e-32	1.35949e-31	1	1	0
ACTRT1	139741	broad.mit.edu	37	X	127185218	127185218	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:127185218G>T	ENST00000371124.3	-	1	1164	c.968C>A	c.(967-969)tCc>tAc	p.S323Y		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	323						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						AGTACCTTTGGAAGCCAGCTG	0.493000													62	50					1.19403e-26	2.10712e-26	1	1	0
RINT1	60561	broad.mit.edu	37	7	105182916	105182916	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:105182916A>C	ENST00000257700.2	+	4	566	c.335A>C	c.(334-336)gAa>gCa	p.E112A	RINT1_ENST00000477285.1_3'UTR	NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	112					cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						AATGCAGAAGAATCAAAGCAA	0.368000													18	78					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160389256	160389256	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:160389256C>T	ENST00000368061.2	+	4	1131	c.657C>T	c.(655-657)gcC>gcT	p.A219A		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	219					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGCAGTTCGCCGTGTCGCTGG	0.627000													20	107					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814207	137814207	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:137814207C>T	ENST00000409968.1	+	3	535	c.357C>T	c.(355-357)taC>taT	p.Y119Y	THSD7B_ENST00000272643.3_Silent_p.Y119Y|THSD7B_ENST00000413152.2_Silent_p.Y88Y					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGTTCCTTACGCTCGCGGTG	0.552000													12	61					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146696969	146696969	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:146696969C>G	ENST00000508784.1	-	10	2892	c.2665G>C	c.(2665-2667)Gat>Cat	p.D889H	ZNF827_ENST00000379448.4_Missense_Mutation_p.D889H|ZNF827_ENST00000513320.1_Missense_Mutation_p.D539H			Q17R98	ZN827_HUMAN	zinc finger protein 827	889					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TTCTTCCCATCACTGCCTTCA	0.502000													24	70					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197297791	197297791	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:197297791G>T	ENST00000367400.3	+	2	445	c.310G>T	c.(310-312)Ggg>Tgg	p.G104W	CRB1_ENST00000367399.2_Missense_Mutation_p.G104W|CRB1_ENST00000535699.1_Missense_Mutation_p.G35W|CRB1_ENST00000538660.1_Missense_Mutation_p.G104W	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	104	EGF-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGGGTACAGTGGGACAATCTG	0.502000													18	53					9.16793e-09	1.12097e-08	1	1	0
SLC7A3	84889	broad.mit.edu	37	X	70145695	70145695	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:70145695C>A	ENST00000374299.3	-	12	1972	c.1828G>T	c.(1828-1830)Gat>Tat	p.D610Y	SLC7A3_ENST00000298085.4_Missense_Mutation_p.D610Y			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	610					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGCCGGGATCAAGGTCTACA	0.498000													64	35					8.77104e-35	1.64457e-34	1	1	0
FSTL1	11167	broad.mit.edu	37	3	120121657	120121657	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:120121657T>A	ENST00000295633.3	-	9	1159	c.803A>T	c.(802-804)gAc>gTc	p.D268V	FSTL1_ENST00000424703.2_Missense_Mutation_p.D233V	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	268	VWFC.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		CAGCTCACCGTCACAGGTCAT	0.517000													40	84					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27150147	27150147	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:27150147G>C	ENST00000396352.4	-	2	312	c.113C>G	c.(112-114)gCt>gGt	p.A38G	HOXA3_ENST00000317201.2_Missense_Mutation_p.A38G|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	38					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GGCGCCCAAAGCGGCGGACGC	0.667000													11	23					0	0	1	0	0
RPAIN	84268	broad.mit.edu	37	17	5329319	5329319	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:5329319G>C	ENST00000381209.3	+	4	912	c.342G>C	c.(340-342)aaG>aaC	p.K114N	CTC-524C5.2_ENST00000575890.1_RNA|RPAIN_ENST00000574003.1_Intron|RPAIN_ENST00000536255.2_Intron|RPAIN_ENST00000405578.4_Missense_Mutation_p.K114N|RPAIN_ENST00000381208.5_Missense_Mutation_p.K114N|RPAIN_ENST00000327154.6_Missense_Mutation_p.K114N	NM_001033002.3	NP_001028174.2	Q86UA6	RIP_HUMAN	RPA interacting protein	114					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|nucleolus|PML body	metal ion binding|protein complex binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)	6						AGTATGAGAAGAGCTTGCAGT	0.458000													4	13					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7520936	7520936	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:7520936C>A	ENST00000338316.4	+	3	583	c.494C>A	c.(493-495)aCc>aAc	p.T165N		NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	165					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AGCGTCCTCACCTCCTCCTCC	0.582000													25	121					5.61819e-17	8.51855e-17	1	1	0
FLG	2312	broad.mit.edu	37	1	152285804	152285804	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:152285804G>T	ENST00000368799.1	-	3	1593	c.1558C>A	c.(1558-1560)Ccg>Acg	p.P520T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	520	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGACCCCGGGTGTCCACGA	0.597000									Ichthyosis				406	474					4.87551e-191	1.00133e-190	1	1	0
MICU1	10367	broad.mit.edu	37	10	74167778	74167778	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:74167778C>G	ENST00000398761.4	-	12	1227	c.1095G>C	c.(1093-1095)gaG>gaC	p.E365D	MICU1_ENST00000361114.5_Missense_Mutation_p.E363D|MICU1_ENST00000398763.4_Missense_Mutation_p.E165D|MICU1_ENST00000418483.2_Missense_Mutation_p.E165D|MICU1_ENST00000401998.3_Missense_Mutation_p.E363D			Q9BPX6	MICU1_HUMAN	mitochondrial calcium uptake 1	363					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding										AGTTCTCCACCTCCTGAAATG	0.423000													18	18					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172634968	172634968	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:172634968C>A	ENST00000367721.2	+	4	842	c.658C>A	c.(658-660)Cag>Aag	p.Q220K	FASLG_ENST00000340030.3_3'UTR	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	220					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						TAAGTATCCCCAGGATCTGGT	0.517000													43	104					1.32136e-16	1.98203e-16	1	1	0
MYO18B	84700	broad.mit.edu	37	22	26164180	26164180	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:26164180T>A	ENST00000335473.7	+	4	547	c.297T>A	c.(295-297)ccT>ccA	p.P99P	MYO18B_ENST00000407587.2_Silent_p.P99P|MYO18B_ENST00000536101.1_Silent_p.P99P	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	99	Ser-rich.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CAAGCTCTCCTGGGAGCTCAG	0.582000													25	98					0	0	1	0	0
PSMG1	8624	broad.mit.edu	37	21	40552326	40552326	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:40552326C>A	ENST00000331573.3	-	3	743	c.278G>T	c.(277-279)tGg>tTg	p.W93L	PSMG1_ENST00000380900.2_Missense_Mutation_p.W93L	NM_001261824.1|NM_003720.3	NP_001248753.1|NP_003711.1	O95456	PSMG1_HUMAN	proteasome (prosome, macropain) assembly chaperone 1	93					proteasome assembly	endoplasmic reticulum	protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	8		Prostate(19;8.44e-08)				AACTTCCTCCCAGACTCCTGA	0.363000													28	100					1.32003e-05	1.48636e-05	1	1	0
MCOLN2	255231	broad.mit.edu	37	1	85397144	85397144	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:85397144C>G	ENST00000370608.3	-	12	1510	c.1443G>C	c.(1441-1443)ctG>ctC	p.L481L	MCOLN2_ENST00000284027.5_Silent_p.L453L	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	481						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		GACGACTGAACAGCCACACCA	0.388000													26	97					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95188810	95188810	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:95188810T>A	ENST00000027335.3	-	5	507	c.383A>T	c.(382-384)cAg>cTg	p.Q128L	CDH17_ENST00000450165.2_Missense_Mutation_p.Q128L|CDH17_ENST00000441892.2_Missense_Mutation_p.Q128L	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	128	Cadherin 1.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTACTTTGACTGGAGAAACGT	0.512000													55	214					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71479622	71479622	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:71479622C>A	ENST00000296755.7	+	3	637	c.339C>A	c.(337-339)atC>atA	p.I113I		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	113						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGGTCCTGATCAACCCTTCTG	0.488000													55	40					6.4308e-24	1.09129e-23	1	1	0
PAX5	5079	broad.mit.edu	37	9	37015150	37015150	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:37015150C>A	ENST00000358127.4	-	3	328	c.254G>T	c.(253-255)gGa>gTa	p.G85V	PAX5_ENST00000414447.1_Missense_Mutation_p.G85V|PAX5_ENST00000520281.1_Missense_Mutation_p.G85V|PAX5_ENST00000523145.1_5'UTR|PAX5_ENST00000377853.2_Missense_Mutation_p.G85V|PAX5_ENST00000377852.2_Missense_Mutation_p.G85V|PAX5_ENST00000522003.1_5'UTR|PAX5_ENST00000446742.1_Intron|PAX5_ENST00000523241.1_Missense_Mutation_p.G85V|PAX5_ENST00000520154.1_Missense_Mutation_p.G85V|PAX5_ENST00000377847.2_Missense_Mutation_p.G85V	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	85	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(42)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		TGGTTTGGATCCTCCAATTAC	0.478000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								40	267					1.47197e-15	2.14662e-15	1	1	0
RYR1	6261	broad.mit.edu	37	19	38956792	38956792	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:38956792C>T	ENST00000355481.4	+	24	3063	c.2932C>T	c.(2932-2934)Ccg>Tcg	p.P978S	RYR1_ENST00000360985.3_Missense_Mutation_p.P978S|RYR1_ENST00000359596.3_Missense_Mutation_p.P978S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	978	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCGGCTGACGCCGGCGCAGAC	0.652000													20	4					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96392312	96392312	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:96392312T>G	ENST00000359246.4	+	2	526	c.159T>G	c.(157-159)tgT>tgG	p.C53W	PHF2_ENST00000375376.4_Missense_Mutation_p.C53W	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	53					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GCCCAAACTGTGAGAAAACCC	0.567000													12	58					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316746	11316746	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:11316746C>T	ENST00000380712.3	+	6	333	c.265C>T	c.(265-267)Ccg>Tcg	p.P89S	ARHGAP6_ENST00000380736.1_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.P75S|ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380732.3_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.P59S	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	75					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel	p.P89T(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						ACAGCACCCCCCGACTCACAC	0.602000													67	69					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750372	94750372	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:94750372G>T	ENST00000306011.3	+	1	331	c.295G>T	c.(295-297)Gtg>Ttg	p.V99L		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	99					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CCGGGACGAGGTGGACGGCCG	0.687000													6	18					3.59834e-05	3.99815e-05	1	1	0
OR7C2	26658	broad.mit.edu	37	19	15052371	15052371	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:15052371A>T	ENST00000248072.3	+	1	71	c.71A>T	c.(70-72)cAg>cTg	p.Q24L		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TCTGACATGCAGCTTCTCCTC	0.532000													57	45					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196963358	196963358	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:196963358G>A	ENST00000367414.5	+	4	707	c.651G>A	c.(649-651)ggG>ggA	p.G217G	CFHR5_ENST00000256785.4_Silent_p.G193G	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	193	Sushi 4.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ACCAATTTGGGTGGTCACCTA	0.318000													75	123					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92401653	92401653	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:92401653C>T	ENST00000276609.3	+	16	2002	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F	SLC26A7_ENST00000520249.1_3'UTR|SLC26A7_ENST00000523719.1_Missense_Mutation_p.S588F|SLC26A7_ENST00000309536.2_Missense_Mutation_p.S588F	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	588	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TCTGGAGTCTCCATGCTTGTT	0.408000													44	491					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140051461	140051461	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:140051461A>T	ENST00000371561.3	+	6	2037	c.940A>T	c.(940-942)Atc>Ttc	p.I314F	GRIN1_ENST00000371550.4_Missense_Mutation_p.I314F|GRIN1_ENST00000371559.4_Missense_Mutation_p.I314F|GRIN1_ENST00000371560.3_Missense_Mutation_p.I335F|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371555.4_Missense_Mutation_p.I335F|GRIN1_ENST00000315048.3_Missense_Mutation_p.I314F|GRIN1_ENST00000350902.5_Missense_Mutation_p.I314F|GRIN1_ENST00000371553.3_Missense_Mutation_p.I335F|GRIN1_ENST00000371546.4_Missense_Mutation_p.I335F	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	314					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CAACACCAACATCTGGAAGAC	0.706000													28	19					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8814695	8814695	+	Silent	SNP	C	C	A	rs4132450	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:8814695C>A	ENST00000359478.2	-	2	193	c.6G>T	c.(4-6)tcG>tcT	p.S2S	MFAP5_ENST00000433590.2_Silent_p.S2S|MFAP5_ENST00000396549.2_Silent_p.S2S|MFAP5_ENST00000540087.1_Silent_p.S2S|MFAP5_ENST00000538107.1_5'UTR|MFAP5_ENST00000543369.1_Silent_p.S2S|MFAP5_ENST00000535336.1_Silent_p.S2S	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	2						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					GTCCCAAGAGCGACATATCTA	0.507000													8	15					0.00307968	0.00323771	1	1	0
LRRIQ4	344657	broad.mit.edu	37	3	169540380	169540380	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:169540380C>A	ENST00000340806.6	+	1	671	c.671C>A	c.(670-672)cCc>cAc	p.P224H		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	224										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						AACAACCTTCCCGTTCTGCCC	0.542000													55	81					9.52127e-25	1.64227e-24	1	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178559281	178559281	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:178559281C>G	ENST00000251582.7	-	15	2341	c.2240G>C	c.(2239-2241)gGa>gCa	p.G747A		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	747	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTGTCTGGCTCCTGCAGGGAT	0.532000													33	37					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102566190	102566190	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:102566190T>C	ENST00000370296.2	+	7	1239	c.689T>C	c.(688-690)gTg>gCg	p.V230A	PAX2_ENST00000361791.3_Missense_Mutation_p.V207A|PAX2_ENST00000355243.3_Missense_Mutation_p.V207A|PAX2_ENST00000556085.1_Missense_Mutation_p.V206A|PAX2_ENST00000428433.1_Missense_Mutation_p.V230A|PAX2_ENST00000553492.1_3'UTR			Q02962	PAX2_HUMAN	paired box 2	230					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TCTCCAGATGTGTCTGAGGGC	0.602000													33	97					0	0	1	0	0
GLT8D2	83468	broad.mit.edu	37	12	104408807	104408807	+	Silent	SNP	C	C	A	rs143684607	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:104408807C>A	ENST00000360814.4	-	4	501	c.96G>T	c.(94-96)gtG>gtT	p.V32V	GLT8D2_ENST00000546436.1_Silent_p.V32V|GLT8D2_ENST00000548660.1_Silent_p.V32V|GLT8D2_ENST00000547583.1_Silent_p.V32V	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	32						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						CATTCTTGGGCACAGTCCCCT	0.433000													6	22					2.0095e-06	2.32504e-06	1	1	0
MYH15	22989	broad.mit.edu	37	3	108189630	108189630	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:108189630G>T	ENST00000273353.3	-	14	1414	c.1358C>A	c.(1357-1359)gCa>gAa	p.A453E		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	453	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTTGATCCGTGCCACTAGCCA	0.458000													29	54					1.2476e-16	1.87811e-16	1	1	0
CREB3L2	64764	broad.mit.edu	37	7	137569712	137569712	+	Missense_Mutation	SNP	C	C	A	rs147128461	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:137569712C>A	ENST00000456390.1	-	10	1660	c.1299G>T	c.(1297-1299)agG>agT	p.R433S	CREB3L2_ENST00000330387.6_Intron			Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	0					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						AAAACAAGACCCTGCCCAACT	0.502000			T	FUS	fibromyxoid sarcoma								27	83					3.90053e-15	5.62963e-15	1	1	0
ENDOD1	23052	broad.mit.edu	37	11	94862629	94862629	+	Silent	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:94862629C>G	ENST00000278505.4	+	2	1507	c.1389C>G	c.(1387-1389)gtC>gtG	p.V463V		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	463						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				GTGGCACTGTCTCACTGCTCT	0.498000													62	134					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200558402	200558402	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:200558402T>A	ENST00000367350.4	-	18	3495	c.3057A>T	c.(3055-3057)gaA>gaT	p.E1019D		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1019	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						ATATTTCCTGTTCAAGATGCT	0.323000													45	74					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807627	143807627	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:143807627C>G	ENST00000408979.2	+	1	1021	c.952C>G	c.(952-954)Ctt>Gtt	p.L318V		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					TGGGCTTTGCCTTTAAAACAT	0.413000													17	118					0	0	1	0	0
SURF4	6836	broad.mit.edu	37	9	136234180	136234180	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:136234180G>A	ENST00000371989.3	-	2	319	c.190C>T	c.(190-192)Ctg>Ttg	p.L64L	SURF4_ENST00000467910.1_5'UTR|SURF4_ENST00000485435.2_Silent_p.L64L|SURF4_ENST00000545297.1_Silent_p.L64L|SURF4_ENST00000371991.3_Silent_p.L64L	NM_033161.2	NP_149351.1	O15260	SURF4_HUMAN	surfeit 4	64						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			kidney(1)|large_intestine(2)|lung(5)	8				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		GAGGCCAGCAGGTAGCCGCAG	0.582000													26	24					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86360275	86360275	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:86360275C>T	ENST00000285381.2	+	7	759	c.676C>T	c.(676-678)Cgg>Tgg	p.R226W	RP11-317J10.2_ENST00000521761.1_RNA|RP11-317J10.2_ENST00000517697.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	226					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GGCCAAGCTGCGGAGCCTCCT	0.537000													5	90					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77274333	77274333	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:77274333T>A	ENST00000388914.3	-	15	2540	c.2388A>T	c.(2386-2388)cgA>cgT	p.R796R		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	796										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GTTCCTGAGATCGCAGAACTT	0.358000													14	41					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158324317	158324317	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:158324317T>A	ENST00000368160.3	+	2	209	c.209T>A	c.(208-210)gTc>gAc	p.V70D	CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368155.3_Missense_Mutation_p.V70D|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.V70D|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.V70D|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.V68D|CD1E_ENST00000368156.1_Missense_Mutation_p.V70D|CD1E_ENST00000368163.3_Missense_Mutation_p.V70D|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368165.3_Missense_Mutation_p.V70D	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	70					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TGGGACACTGTCTTGGGCACC	0.532000													30	67					0	0	1	0	0
NXF4	55999	broad.mit.edu	37	X	101821916	101821916	+	RNA	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:101821916T>A	ENST00000360035.2	+	0	1669					NR_002216.1															endometrium(2)|lung(8)	10						CAGCATGACCTTAACTCCTAT	0.517000													9	19					0	0	1	0	0
SCFD2	152579	broad.mit.edu	37	4	54232062	54232062	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:54232062T>A	ENST00000401642.3	-	1	180	c.47A>T	c.(46-48)cAg>cTg	p.Q16L	SCFD2_ENST00000388940.4_Missense_Mutation_p.Q16L	NM_152540.3	NP_689753.2	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	16					protein transport|vesicle docking involved in exocytosis					breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	30			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GGCCAGCACCTGCTCCCATCC	0.612000													29	87					0	0	1	0	0
KLRAP1	10748	broad.mit.edu	37	12	10750682	10750682	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:10750682C>A	ENST00000510134.2	-	0	274																				breast(1)|large_intestine(1)|lung(1)	3						TATCATCAGGCCTTAATCTAT	0.373000													55	165					8.4772e-36	1.61837e-35	1	1	0
HRG	3273	broad.mit.edu	37	3	186395473	186395473	+	Missense_Mutation	SNP	G	G	T	rs148716747	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:186395473G>T	ENST00000232003.4	+	7	1459	c.1379G>T	c.(1378-1380)cGa>cTa	p.R460L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	460	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TCTGTGTACCGACTCCCTCCT	0.547000													71	86					1.43675e-24	2.45799e-24	1	1	0
SEMA6D	80031	broad.mit.edu	37	15	48063679	48063679	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:48063679T>C	ENST00000316364.5	+	19	3358	c.2919T>C	c.(2917-2919)tcT>tcC	p.S973S	SEMA6D_ENST00000537942.1_Silent_p.S911S|SEMA6D_ENST00000558816.1_3'UTR|SEMA6D_ENST00000558014.1_Silent_p.S911S|SEMA6D_ENST00000389432.2_Silent_p.S930S|SEMA6D_ENST00000358066.4_Silent_p.S911S|SEMA6D_ENST00000389433.2_Silent_p.S954S|SEMA6D_ENST00000354744.4_Silent_p.S917S|SEMA6D_ENST00000389428.3_Silent_p.S898S|SEMA6D_ENST00000536845.2_Silent_p.S973S|SEMA6D_ENST00000355997.3_3'UTR	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	973					axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AGAGGCACTCTATATCTGCTA	0.483000													35	139					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76376476	76376476	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:76376476G>T	ENST00000370014.3	+	10	1662	c.1043G>T	c.(1042-1044)aGa>aTa	p.R348I	SENP6_ENST00000327284.8_Missense_Mutation_p.R341I|SENP6_ENST00000447266.2_Missense_Mutation_p.R348I|SENP6_ENST00000370010.2_Missense_Mutation_p.R341I	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	348					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				ACTAACAGAAGAGAAAGCATA	0.343000													19	65					3.32936e-07	3.92239e-07	1	1	0
MAP1A	4130	broad.mit.edu	37	15	43818676	43818676	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:43818676C>A	ENST00000382031.1	+	5	5750	c.5719C>A	c.(5719-5721)Ccg>Acg	p.P1907T	MAP1A_ENST00000300231.5_Missense_Mutation_p.P1669T|MAP1A_ENST00000399453.1_Missense_Mutation_p.P1669T			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1669						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAGCTTGCCCCGGCATGGGA	0.562000													10	13					0.000442599	0.000476645	1	1	0
TRIM10	10107	broad.mit.edu	37	6	30121521	30121521	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:30121521C>A	ENST00000376704.3	-	8	1207	c.1132G>T	c.(1132-1134)Ggc>Tgc	p.G378C	TRIM10_ENST00000449742.2_3'UTR	NM_052828.2	NP_439893.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	0	B30.2/SPRY.					cytoplasm	zinc ion binding			ovary(1)	1						TGGCAGCAGCCTGAGTCCCCA	0.547000													7	33					0.0293803	0.0300237	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190250787	190250787	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:190250787G>C	ENST00000367462.3	-	3	561	c.330C>G	c.(328-330)aaC>aaG	p.N110K	FAM5C_ENST00000484105.1_Intron|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000534846.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		110						extracellular region		p.N110K(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AAAGTCTTATGTTGCGGAAGA	0.448000													45	107					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139155316	139155316	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:139155316G>C	ENST00000395297.1	-	16	3747	c.3577C>G	c.(3577-3579)Cgg>Ggg	p.R1193G		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1193										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCCAATAACCGATCCGTCATA	0.458000										HNSCC(54;0.14)			10	114					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20080404	20080404	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:20080404G>T	ENST00000351989.3	+	8	2108	c.1679G>T	c.(1678-1680)aGc>aTc	p.S560I	DGCR8_ENST00000383024.2_Intron|DGCR8_ENST00000407755.1_Intron	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	560	DRBM 1.|Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding	p.S560I(1)		NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					ACTGCAAGCAGCAAAAAACTT	0.463000													68	77					5.80444e-35	1.09321e-34	1	1	0
TRIM55	84675	broad.mit.edu	37	8	67047232	67047232	+	Nonsense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:67047232A>T	ENST00000315962.4	+	3	722	c.349A>T	c.(349-351)Aag>Tag	p.K117*	TRIM55_ENST00000353317.5_Nonsense_Mutation_p.K117*|TRIM55_ENST00000350034.4_Nonsense_Mutation_p.K117*|TRIM55_ENST00000276573.7_Nonsense_Mutation_p.K117*	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	117						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CAGGCCAGAAAAGAAATCCGA	0.512000													12	138					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186670281	186670281	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:186670281C>A	ENST00000343098.5	+	17	16515	c.16515C>A	c.(16513-16515)acC>acA	p.T5505T	FSIP2_ENST00000424728.1_Silent_p.T5416T	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						ATAATATCACCCAAAGGGTTC	0.373000													58	76					1.80625e-27	3.21452e-27	1	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762062	130762062	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:130762062C>A	ENST00000392429.1	+	2	2873	c.495C>A	c.(493-495)tcC>tcA	p.S165S	TMEM200A_ENST00000545622.1_Silent_p.S165S|TMEM200A_ENST00000296978.3_Silent_p.S165S	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	165						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATATCTATTCCACAGTCATTG	0.403000													26	70					2.79863e-10	3.58361e-10	1	1	0
DPF2	5977	broad.mit.edu	37	11	65108946	65108946	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:65108946C>T	ENST00000528416.1	+	4	511	c.378C>T	c.(376-378)gaC>gaT	p.D126D	DPF2_ENST00000415073.2_Silent_p.D126D|DPF2_ENST00000532264.1_3'UTR|DPF2_ENST00000252268.4_Silent_p.D126D	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	126					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						TGCGCACTGACCCCCTGGAGA	0.562000													16	58					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37737135	37737135	+	Missense_Mutation	SNP	G	G	T	rs34684414		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:37737135G>T	ENST00000539465.1	+	14	2037	c.1444G>T	c.(1444-1446)Gcc>Tcc	p.A482S	FRMPD1_ENST00000541302.1_Missense_Mutation_p.A351S|FRMPD1_ENST00000377765.3_Missense_Mutation_p.A482S|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.A304S			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	482	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AAAAGACCTAGCCTGCCTGAT	0.473000													45	63					2.58029e-29	4.6813e-29	1	1	0
ALPK2	115701	broad.mit.edu	37	18	56204259	56204259	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:56204259G>T	ENST00000361673.3	-	5	3373	c.3160C>A	c.(3160-3162)Caa>Aaa	p.Q1054K	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1054							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						AACTGCACTTGGGAAGGAAAT	0.488000													60	47					2.40265e-35	4.54555e-35	1	1	0
ACTL7B	10880	broad.mit.edu	37	9	111617915	111617915	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:111617915C>G	ENST00000374667.3	-	1	1324	c.296G>C	c.(295-297)gGc>gCc	p.G99A		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	99						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CAGCTCATGGCCCACTAAAGT	0.652000													17	194					0	0	1	0	0
GYG1	2992	broad.mit.edu	37	3	148727066	148727066	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:148727066G>T	ENST00000345003.4	+	5	785	c.485G>T	c.(484-486)gGg>gTg	p.G162V	GYG1_ENST00000479119.1_3'UTR|GYG1_ENST00000484197.1_Missense_Mutation_p.G162V|GYG1_ENST00000296048.6_Missense_Mutation_p.G162V|GYG1_ENST00000483267.1_Intron	NM_004130.3	NP_004121.2	P46976	GLYG_HUMAN	glycogenin 1	162					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CTTTTAGGTGGGGACCAAGGC	0.328000													47	98					2.40228e-13	3.33539e-13	1	1	0
TTC3	7267	broad.mit.edu	37	21	38538595	38538595	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:38538595A>C	ENST00000399017.2	+	33	6826	c.4079A>C	c.(4078-4080)cAg>cCg	p.Q1360P	TTC3_ENST00000354749.2_Missense_Mutation_p.Q1360P|TTC3_ENST00000355666.1_Missense_Mutation_p.Q1360P|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1360					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				CCTGAATATCAGCTACCAAGA	0.468000													30	138					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76107310	76107310	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:76107310T>C	ENST00000238667.4	+	7	1604	c.1248T>C	c.(1246-1248)acT>acC	p.T416T	FLVCR2_ENST00000553587.1_Intron|FLVCR2_ENST00000539311.1_Silent_p.T211T|FLVCR2_ENST00000555027.1_Silent_p.T131T|FLVCR2_ENST00000556241.1_Intron|FLVCR2_ENST00000556856.1_Intron	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	416					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		TCTTTATGACTGGCTATCTCC	0.522000													28	37					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103357641	103357641	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:103357641C>A	ENST00000520539.1	-	8	1475	c.869G>T	c.(868-870)aGg>aTg	p.R290M	UBR5_ENST00000521922.1_Missense_Mutation_p.R290M|UBR5_ENST00000220959.4_Missense_Mutation_p.R290M	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	290					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGAGCCTAGCCTGGAAAGTGA	0.383000													8	41					0.000157383	0.000171246	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11865293	11865293	+	Missense_Mutation	SNP	C	C	A	rs138162394		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:11865293C>A	ENST00000262442.3	+	68	13021	c.12953C>A	c.(12952-12954)gCa>gAa	p.A4318E	DNAH9_ENST00000454412.2_Missense_Mutation_p.A4242E|DNAH9_ENST00000396001.2_Missense_Mutation_p.A630E|RP11-1096G20.5_ENST00000580270.1_RNA	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4318					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCAGGCCTGGCAGCCTGGTTT	0.542000													18	76					1.56452e-12	2.12654e-12	1	1	0
ZFPM2	23414	broad.mit.edu	37	8	106814594	106814594	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:106814594G>T	ENST00000407775.2	+	8	2534	c.2284G>T	c.(2284-2286)Gac>Tac	p.D762Y	RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.D630Y|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000378472.4_Missense_Mutation_p.D493Y|ZFPM2_ENST00000517361.1_Missense_Mutation_p.D630Y|RP11-152P17.2_ENST00000520594.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	762					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGATTTCTTGACGTAGCCAA	0.493000													24	55					6.44725e-10	8.16846e-10	1	1	0
GPR97	222487	broad.mit.edu	37	16	57718061	57718061	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:57718061G>T	ENST00000333493.4	+	9	1260	c.1099G>T	c.(1099-1101)Gct>Tct	p.A367S	RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000327655.6_Missense_Mutation_p.A157S|GPR97_ENST00000450388.3_Missense_Mutation_p.A247S	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	367					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTACCTGCTCGCTGTCAGGGT	0.607000													45	95					7.05121e-23	1.17287e-22	1	1	0
CNTN5	53942	broad.mit.edu	37	11	100170000	100170000	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:100170000C>A	ENST00000524871.1	+	20	2782	c.2492C>A	c.(2491-2493)gCt>gAt	p.A831D	CNTN5_ENST00000418526.2_Missense_Mutation_p.A757D|CNTN5_ENST00000528682.1_Missense_Mutation_p.A831D|CNTN5_ENST00000279463.3_Missense_Mutation_p.A831D|CNTN5_ENST00000527185.1_Missense_Mutation_p.A831D|CNTN5_ENST00000524560.1_3'UTR	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	831	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCCTCTGAAGCTTCCAAATTC	0.428000													12	95					0.000978159	0.00103875	1	1	0
KRBA1	84626	broad.mit.edu	37	7	149423124	149423124	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:149423124G>T	ENST00000255992.10	+	11	1846	c.1447G>T	c.(1447-1449)Ggg>Tgg	p.G483W	KRBA1_ENST00000319551.8_Missense_Mutation_p.G483W|KRBA1_ENST00000485033.2_Missense_Mutation_p.G483W|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	483										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGTCCTGTGGGGAACCAGGG	0.662000													5	12					0.014758	0.0151549	1	1	0
SDK1	221935	broad.mit.edu	37	7	4091284	4091284	+	Silent	SNP	G	G	T	rs151201149		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:4091284G>T	ENST00000404826.2	+	19	2872	c.2733G>T	c.(2731-2733)ccG>ccT	p.P911P	SDK1_ENST00000389531.3_Silent_p.P911P	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	911	Fibronectin type-III 3.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGGCATGGCCGGCAGATGCCC	0.493000													28	95					4.15321e-07	4.88613e-07	1	1	0
MBOAT1	154141	broad.mit.edu	37	6	20131385	20131385	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:20131385C>A	ENST00000324607.7	-	5	629	c.465G>T	c.(463-465)caG>caT	p.Q155H	MBOAT1_ENST00000541730.1_Intron|MBOAT1_ENST00000536798.1_Missense_Mutation_p.Q155H	NM_001080480.1	NP_001073949.1	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	155					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CATCATGAACCTGGAATGCCA	0.438000													22	92					1.28384e-07	1.53185e-07	1	1	0
DMXL1	1657	broad.mit.edu	37	5	118506226	118506226	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:118506226G>T	ENST00000311085.8	+	24	5820	c.5740G>T	c.(5740-5742)Gca>Tca	p.A1914S	DMXL1_ENST00000539542.1_Missense_Mutation_p.A1914S	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1914										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAAGTTGGATGCAAGGGAAGA	0.398000													36	92					1.07637e-12	1.46777e-12	1	1	0
COL3A1	1281	broad.mit.edu	37	2	189875080	189875080	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:189875080G>A	ENST00000304636.3	+	49	4170	c.4000G>A	c.(4000-4002)Ggt>Agt	p.G1334S	COL3A1_ENST00000317840.5_Missense_Mutation_p.G1031S	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1334	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GTCCATGGATGGTGGTTTTCA	0.388000													70	62					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138671204	138671204	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:138671204G>T	ENST00000298480.5	+	24	2803		c.e24-1		KCNT1_ENST00000491806.2_Splice_Site|KCNT1_ENST00000486577.2_Splice_Site|KCNT1_ENST00000490355.2_Splice_Site|KCNT1_ENST00000371757.2_Splice_Site|KCNT1_ENST00000263604.3_Splice_Site|KCNT1_ENST00000488444.2_Splice_Site|KCNT1_ENST00000487664.1_Splice_Site			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1							membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GCCTCCCCCAGGCTCTTCCCC	0.652000													23	80					3.65163e-15	5.27946e-15	1	1	0
NLRP7	199713	broad.mit.edu	37	19	55451188	55451188	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:55451188G>T	ENST00000588756.1	-	6	1485	c.999C>A	c.(997-999)ttC>ttA	p.F333L	NLRP7_ENST00000340844.2_Missense_Mutation_p.F333L|NLRP7_ENST00000592784.1_Missense_Mutation_p.F333L|NLRP7_ENST00000590030.1_Missense_Mutation_p.F333L|NLRP7_ENST00000328092.5_Missense_Mutation_p.F333L|NLRP7_ENST00000448121.2_Missense_Mutation_p.F333L|NLRP7_ENST00000446217.1_Missense_Mutation_p.F361L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	333	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGTGTCTCAGGAAATAGGCCC	0.647000													29	22					7.26314e-15	1.04113e-14	1	1	0
NXF4	55999	broad.mit.edu	37	X	101826499	101826499	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:101826499C>A	ENST00000360035.2	+	0	3493					NR_002216.1															endometrium(2)|lung(8)	10						CCTGGCTCACCGGAAAGCCAA	0.478000													7	4					0.0293803	0.0300237	1	1	0
HGF	3082	broad.mit.edu	37	7	81381531	81381531	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:81381531C>A	ENST00000222390.5	-	5	756	c.530G>T	c.(529-531)tGt>tTt	p.C177F	HGF_ENST00000457544.2_Missense_Mutation_p.C172F|HGF_ENST00000453411.1_Missense_Mutation_p.C172F|HGF_ENST00000423064.2_Missense_Mutation_p.C177F|HGF_ENST00000444829.2_Missense_Mutation_p.C177F	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	177	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						AGGATTTCGACAGTAGTTTTC	0.428000													28	71					1.16021e-09	1.46333e-09	1	1	0
PRPF19	27339	broad.mit.edu	37	11	60665647	60665647	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:60665647C>A	ENST00000227524.4	-	14	1442	c.1237G>T	c.(1237-1239)Gac>Tac	p.D413Y		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	413					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						ACAGAGGAGTCATCAGCCGCT	0.537000													34	68					5.09552e-08	6.16749e-08	1	1	0
BCRP7	100133163	broad.mit.edu	37	22	18846096	18846096	+	RNA	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:18846096G>C	ENST00000412938.1	+	0	3454																											CCATGCCTCGGCGCTCGATCT	0.627000													4	41					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100341940	100341940	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:100341940C>A	ENST00000437033.2	-	6	1078	c.575G>T	c.(574-576)gGt>gTt	p.G192V	ADH7_ENST00000482593.1_Missense_Mutation_p.G135V|ADH7_ENST00000209665.4_Missense_Mutation_p.G204V|ADH7_ENST00000476959.1_Missense_Mutation_p.G212V			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	204					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	GCAAGTGGAACCAGGTTTGAC	0.473000													17	23					1.15088e-07	1.37516e-07	1	1	0
ARMC12	221481	broad.mit.edu	37	6	35704940	35704940	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:35704940G>T	ENST00000373866.3	+	1	77	c.55G>T	c.(55-57)Gtc>Ttc	p.V19F	ARMC12_ENST00000373869.3_Missense_Mutation_p.V19F|ARMC12_ENST00000288065.2_Missense_Mutation_p.V19F			Q5T9G4	CF081_HUMAN	armadillo repeat containing 12	19							binding										CAAAAGCGTAGTCAGCCTGGC	0.587000											OREG0017379	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	43					3.62473e-10	4.60632e-10	1	1	0
MEGF6	1953	broad.mit.edu	37	1	3432079	3432079	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:3432079C>T	ENST00000356575.4	-	6	843	c.617G>A	c.(616-618)tGc>tAc	p.C206Y	MEGF6_ENST00000294599.4_Missense_Mutation_p.C101Y	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	206	EGF-like 3.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCCAGGGCGCAGGAGTTAAT	0.657000													13	35					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17362943	17362943	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:17362943G>T	ENST00000377602.4	-	8	1205	c.1131C>A	c.(1129-1131)agC>agA	p.S377R		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	377					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						GGAGGATCTGGCTGTATTCTT	0.378000													235	172					3.00754e-112	6.13189e-112	1	1	0
TMEM131	23505	broad.mit.edu	37	2	98458307	98458307	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:98458307T>C	ENST00000186436.5	-	7	922	c.694A>G	c.(694-696)Atc>Gtc	p.I232V	TMEM131_ENST00000425805.2_Missense_Mutation_p.I183V	NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	232						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GGATTGTGGATGTTTATTATA	0.408000													5	8					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157193	26157193	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:26157193A>G	ENST00000325250.1	+	2	278	c.91A>G	c.(91-93)Act>Gct	p.T31A		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	31							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						TACGCAGGCCACTGTGGCAGA	0.552000													30	22					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236208834	236208834	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:236208834T>C	ENST00000264187.6	-	3	757	c.675A>G	c.(673-675)tcA>tcG	p.S225S	NID1_ENST00000366595.3_Silent_p.S225S	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	225	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AGAATCCCACTGAACCTTGAC	0.413000													55	63					0	0	1	0	0
PXDC1	221749	broad.mit.edu	37	6	3751616	3751616	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:3751616C>A	ENST00000380283.4	-	1	644	c.150G>T	c.(148-150)gtG>gtT	p.V50V	RP11-420L9.5_ENST00000603791.1_RNA|PXDC1_ENST00000477592.2_5'UTR	NM_183373.3	NP_899229.2	Q5TGL8	CF145_HUMAN	PX domain containing 1	50	PX.				cell communication		phosphatidylinositol binding										GCAGGTAGAGCACGCTGCGGT	0.716000													3	2					0.00024832	0.000269843	1	1	0
AQP7	364	broad.mit.edu	37	9	33386974	33386974	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:33386974G>T	ENST00000539936.1	-	4	499	c.261C>A	c.(259-261)cgC>cgA	p.R87R	AQP7_ENST00000541274.1_Intron|AQP7_ENST00000377425.4_Silent_p.R30R|AQP7_ENST00000537089.1_Intron			O14520	AQP7_HUMAN	aquaporin 7	87					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CACCAGAGATGCGGCCTGCCA	0.582000													15	138					4.14922e-12	5.58548e-12	1	1	0
TENM1	10178	broad.mit.edu	37	X	123615742	123615742	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:123615742A>T	ENST00000422452.2	-	22	3852	c.3789T>A	c.(3787-3789)aaT>aaA	p.N1263K	TENM1_ENST00000371130.3_Missense_Mutation_p.N1256K|TENM1_ENST00000461429.1_5'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTTTGCGAGTATTGGTGTCTG	0.423000													35	104					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087201	9087201	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:9087201G>A	ENST00000397910.4	-	1	4817	c.4614C>T	c.(4612-4614)acC>acT	p.T1538T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1538	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGTCAGTGGGGTGATAGGAA	0.478000													109	84					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109577486	109577486	+	Silent	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:109577486A>C	ENST00000338432.7	+	2	395	c.276A>C	c.(274-276)ctA>ctC	p.L92L	ACACB_ENST00000377848.3_Silent_p.L92L|ACACB_ENST00000377854.5_Silent_p.L92L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	92					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GAAACTCCCTACCACCCTCCC	0.627000													20	152					0	0	1	0	0
ELF1	1997	broad.mit.edu	37	13	41517143	41517143	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:41517143C>A	ENST00000239882.3	-	7	1065	c.751G>T	c.(751-753)Ggg>Tgg	p.G251W	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.G227W	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	251					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		TTGTGCTTCCCCCACAACCTG	0.408000													15	63					2.32078e-09	2.89667e-09	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80835441	80835441	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:80835441G>T	ENST00000466387.1	+	21	3152	c.2428G>T	c.(2428-2430)Ggg>Tgg	p.G810W	CTNNA2_ENST00000402739.4_Missense_Mutation_p.G810W|CTNNA2_ENST00000343114.3_Missense_Mutation_p.G489W|CTNNA2_ENST00000541047.1_Missense_Mutation_p.G810W|CTNNA2_ENST00000540488.1_Intron|AC008067.2_ENST00000430876.1_RNA|CTNNA2_ENST00000361291.4_Missense_Mutation_p.G844W|CTNNA2_ENST00000496558.1_Missense_Mutation_p.G810W			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	810					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton	p.G810R(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CATTGTGTCAGGGGTAAGCTG	0.468000													9	38					0.335167	0.335967	1	1	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465993	24465993	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:24465993C>T	ENST00000382137.3	-	3	505	c.437G>A	c.(436-438)gGc>gAc	p.G146D	C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.G146D|C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B_ENST00000556521.1_Intron|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B-AS1_ENST00000417034.1_RNA|C1QTNF9B_ENST00000382145.1_Intron|C1QTNF9B-AS1_ENST00000382133.4_RNA	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	146	Collagen-like 2.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						ACCAGTTGGGCCCAAAGGCCC	0.662000													6	22					0	0	1	0	0
ZFP91-CNTF	386607	broad.mit.edu	37	11	58390246	58390246	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:58390246A>T	ENST00000389919.4	+	12	1693	c.1583A>T	c.(1582-1584)cAc>cTc	p.H528L	CNTF_ENST00000361987.4_Silent_p.S7S																cervix(1)|endometrium(3)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CAGAGCATTCACCGCTGACCC	0.488000													10	23					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	69990455	69990455	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:69990455G>T	ENST00000352241.4	+	5	898	c.735G>T	c.(733-735)atG>atT	p.M245I	MITF_ENST00000448226.2_Missense_Mutation_p.M245I|MITF_ENST00000394351.3_Missense_Mutation_p.M138I|MITF_ENST00000314589.5_Missense_Mutation_p.M229I|MITF_ENST00000472437.1_Missense_Mutation_p.M193I|MITF_ENST00000531774.1_Missense_Mutation_p.M82I|MITF_ENST00000394355.2_Missense_Mutation_p.M220I|MITF_ENST00000328528.6_Missense_Mutation_p.M244I|MITF_ENST00000314557.6_Missense_Mutation_p.M138I	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	245	Transactivation.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		TGGGCTTGATGGATCCTGCTT	0.348000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						12	42					0.00185496	0.00195996	1	1	0
KIAA0020	9933	broad.mit.edu	37	9	2811432	2811432	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:2811432C>A	ENST00000397885.2	-	15	1770	c.1564G>T	c.(1564-1566)Gtt>Ttt	p.V522F		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	522						endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		GTAGGCTGAACGTCTCCAGTG	0.522000													29	119					1.77063e-15	2.57324e-15	1	1	0
WDR7	23335	broad.mit.edu	37	18	54339881	54339881	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:54339881C>T	ENST00000254442.3	+	2	346	c.135C>T	c.(133-135)ctC>ctT	p.L45L	WDR7_ENST00000357574.3_Silent_p.L45L|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	45										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		AAATATGTCTCTGGGATCTTT	0.398000													26	26					0	0	1	0	0
RGS7BP	401190	broad.mit.edu	37	5	63803677	63803677	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:63803677C>A	ENST00000334025.2	+	2	631	c.305C>A	c.(304-306)gCa>gAa	p.A102E	RGS7BP_ENST00000508162.1_Intron	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	102					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		GCCCGTCAGGCACACCAAAAA	0.488000													22	14					5.26018e-13	7.23167e-13	1	1	0
KCNA4	3739	broad.mit.edu	37	11	30032622	30032622	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:30032622A>T	ENST00000328224.6	-	2	2837	c.1604T>A	c.(1603-1605)gTa>gAa	p.V535E		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	535						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTTGCCCCCTACAGTGATGGG	0.498000													16	78					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834577	125834577	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:125834577G>A	ENST00000299308.3	+	2	640	c.632G>A	c.(631-633)gGg>gAg	p.G211E		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	211						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCCCTGCTCGGGGGCACCACG	0.632000													52	31					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123615743	123615743	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:123615743T>A	ENST00000422452.2	-	22	3851	c.3788A>T	c.(3787-3789)aAt>aTt	p.N1263I	TENM1_ENST00000371130.3_Missense_Mutation_p.N1256I|TENM1_ENST00000461429.1_5'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTGCGAGTATTGGTGTCTGA	0.418000													34	104					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124378304	124378304	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:124378304G>A	ENST00000360013.3	+	43	6340	c.6213_splice	c.e43+1	p.K2071_splice	KALRN_ENST00000428018.2_Splice_Site_p.K342_splice|KALRN_ENST00000393496.1_Splice_Site_p.K412_splice|KALRN_ENST00000291478.4_Splice_Site_p.K374_splice|KALRN_ENST00000459915.1_Splice_Site_p.K163_splice	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2070	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGCTCCTCAAGGTAAGAAGCT	0.502000													22	91					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41019265	41019265	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:41019265G>T	ENST00000352632.3	+	14	2655	c.2569G>T	c.(2569-2571)Gtg>Ttg	p.V857L	SPTBN4_ENST00000598249.1_Missense_Mutation_p.V857L|SPTBN4_ENST00000338932.3_Missense_Mutation_p.V857L|SPTBN4_ENST00000344104.3_Missense_Mutation_p.V857L|SPTBN4_ENST00000595535.1_Missense_Mutation_p.V857L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	857					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGTGCGCGTGGTGGAAGCAGA	0.711000													9	4					0.000442599	0.000476645	1	1	0
TAF1L	138474	broad.mit.edu	37	9	32633492	32633492	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:32633492C>A	ENST00000242310.4	-	1	2175	c.2086G>T	c.(2086-2088)Gat>Tat	p.D696Y	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	696					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGAATAAGATCTCCATCTTTG	0.428000													76	126					3.12118e-38	6.01329e-38	1	1	0
PACRG	135138	broad.mit.edu	37	6	163510298	163510298	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:163510298G>T	ENST00000337019.3	+	5	695	c.471G>T	c.(469-471)ttG>ttT	p.L157F	PACRG_ENST00000366888.2_Missense_Mutation_p.L157F|PACRG_ENST00000366889.2_Missense_Mutation_p.L157F	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	157										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		TAGATGCCTTGAACCTCCGAA	0.443000													43	47					9.39024e-22	1.51981e-21	1	1	0
PCK2	5106	broad.mit.edu	37	14	24567862	24567862	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:24567862C>T	ENST00000545054.2	+	4	1155	c.237C>T	c.(235-237)tcC>tcT	p.S79S	PCK2_ENST00000396973.4_Silent_p.S213S|PCK2_ENST00000558096.1_Silent_p.S79S|PCK2_ENST00000216780.4_Silent_p.S213S|PCK2_ENST00000559250.1_Silent_p.S225S|NRL_ENST00000561028.1_Intron|PCK2_ENST00000561286.1_Silent_p.S79S			Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	213					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			breast(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(265;0.0184)		GTCTGCACTCCGTGGGCCAGC	0.562000													12	20					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113988350	113988350	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:113988350G>A	ENST00000297405.5	-	7	1302	c.1058C>T	c.(1057-1059)tCc>tTc	p.S353F	CSMD3_ENST00000455883.2_Intron|CSMD3_ENST00000352409.3_Missense_Mutation_p.S353F|CSMD3_ENST00000343508.3_Missense_Mutation_p.S313F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	353						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTCACCAGTGGAGGTAGTGTG	0.403000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			82	205					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188170	152188170	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:152188170G>T	ENST00000368801.2	-	3	6010	c.5935C>A	c.(5935-5937)Cca>Aca	p.P1979T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1979					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTCATATGGGCCACGGCTG	0.597000													101	1756					2.27459e-33	4.23649e-33	1	1	0
SI	6476	broad.mit.edu	37	3	164766972	164766972	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:164766972C>A	ENST00000264382.3	-	15	1720	c.1658G>T	c.(1657-1659)gGt>gTt	p.G553V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	553	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATACTGTTTACCCCAGTTCTG	0.343000										HNSCC(35;0.089)			14	69					0.00498961	0.00518722	1	1	0
CHD5	26038	broad.mit.edu	37	1	6208915	6208915	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:6208915G>T	ENST00000262450.3	-	9	1481	c.1383_splice	c.e9+1	p.T461_splice	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	461	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AACACTCACAGTACAGCGCGG	0.721000													19	33					2.4624e-09	3.06886e-09	1	1	0
PTPN13	5783	broad.mit.edu	37	4	87680206	87680206	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:87680206C>T	ENST00000436978.1	+	23	4013	c.3533C>T	c.(3532-3534)cCa>cTa	p.P1178L	PTPN13_ENST00000316707.6_Missense_Mutation_p.P987L|PTPN13_ENST00000511467.1_Missense_Mutation_p.P1178L|PTPN13_ENST00000411767.2_Missense_Mutation_p.P1178L|PTPN13_ENST00000427191.2_Missense_Mutation_p.P1159L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1178	PDZ 1.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ATCTCTCAGCCAAAAGAAAAG	0.368000													8	38					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258428	56258428	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56258428C>A	ENST00000327216.2	-	1	443	c.419G>T	c.(418-420)tGc>tTc	p.C140F		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					GAGGAAGGAGCACACACTCTT	0.522000													48	64					2.61675e-31	4.77842e-31	1	1	0
BRD3	8019	broad.mit.edu	37	9	136918440	136918440	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:136918440G>A	ENST00000303407.7	-	2	345	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	BRD3_ENST00000357885.2_Nonsense_Mutation_p.Q54*|BRD3_ENST00000371834.2_Nonsense_Mutation_p.Q54*	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	54	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CAGGCGAACTGGTGTTTCCAG	0.627000			T	C15orf55	lethal midline carcinoma of young people								13	59					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82476511	82476511	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:82476511T>A	ENST00000423517.2	-	11	14044	c.13707A>T	c.(13705-13707)gaA>gaT	p.E4569D	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Missense_Mutation_p.E4569D	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4457	C2 1.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTGAACTTCTTCATATGTTT	0.358000													11	16					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152320733	152320733	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:152320733A>C	ENST00000243326.4	+	29	5182	c.4699A>C	c.(4699-4701)Aag>Cag	p.K1567Q	RIF1_ENST00000444746.2_Missense_Mutation_p.K1567Q|RIF1_ENST00000430328.2_Missense_Mutation_p.K1567Q|RIF1_ENST00000453091.2_Missense_Mutation_p.K1567Q|RIF1_ENST00000428287.2_Missense_Mutation_p.K1567Q			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1567					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTCTAGGAAGAAGAGATCTGG	0.373000													18	62					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75185334	75185334	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:75185334G>A	ENST00000336926.6	-	18	1849	c.1823C>T	c.(1822-1824)aCa>aTa	p.T608I	HIP1_ENST00000434438.2_Missense_Mutation_p.T608I	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	608					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						ACTTGCCTCTGTGCTGGCCAG	0.612000			T	PDGFRB	CMML								66	170					0	0	1	0	0
MFSD10	10227	broad.mit.edu	37	4	2934922	2934922	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:2934922C>T	ENST00000329687.4	-	3	817	c.283G>A	c.(283-285)Gca>Aca	p.A95T	MFSD10_ENST00000508221.1_Missense_Mutation_p.A95T|MFSD10_ENST00000514800.1_Missense_Mutation_p.A95T|MFSD10_ENST00000355443.4_Missense_Mutation_p.A95T|MFSD10_ENST00000507555.1_Missense_Mutation_p.A95T	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	95					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		ACAGAGAATGCCGAGCCAATG	0.612000													3	33					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27448890	27448890	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:27448890C>A	ENST00000337929.3	+	4	707	c.234C>A	c.(232-234)acC>acA	p.T78T	IL21R_ENST00000395755.1_Silent_p.T78T|IL21R_ENST00000564089.1_Silent_p.T78T|IL21R_ENST00000395754.4_Silent_p.T78T	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	78					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						CGCATGCCACCTACACCTGCC	0.557000			T	BCL6	NHL								40	94					1.47244e-24	2.51393e-24	1	1	0
KBTBD3	143879	broad.mit.edu	37	11	105924081	105924081	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:105924081G>C	ENST00000526793.1	-	3	1494	c.1335C>G	c.(1333-1335)taC>taG	p.Y445*	KBTBD3_ENST00000531837.1_Nonsense_Mutation_p.Y445*|KBTBD3_ENST00000534815.1_Nonsense_Mutation_p.Y366*	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	441										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTTCTGGATAGTATATGCCTC	0.373000													34	75					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106497819	106497819	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:106497819G>T	ENST00000233154.4	+	4	704	c.262G>T	c.(262-264)Gat>Tat	p.D88Y	NCK2_ENST00000393349.2_Missense_Mutation_p.D88Y|NCK2_ENST00000451463.2_Intron|NCK2_ENST00000522586.1_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	88					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CAGCGCGCGGGATGCGTCCCC	0.677000													12	20					1.08611e-07	1.30519e-07	1	1	0
MYH4	4622	broad.mit.edu	37	17	10356595	10356595	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:10356595C>A	ENST00000255381.2	-	24	3095	c.2985G>T	c.(2983-2985)aaG>aaT	p.K995N	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	995					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CCTTGGTCAGCTTAGCAATGG	0.473000													41	148					4.67007e-22	7.64689e-22	1	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84605750	84605750	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:84605750G>T	ENST00000344803.2	+	4	412	c.365G>T	c.(364-366)cGa>cTa	p.R122L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CACTTTCGTCGACTGTTATGC	0.527000													8	19					5.18039e-06	5.89638e-06	1	1	0
PARD3B	117583	broad.mit.edu	37	2	205986661	205986661	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:205986661G>A	ENST00000406610.2	+	8	1360	c.1153G>A	c.(1153-1155)Gac>Aac	p.D385N	PARD3B_ENST00000462231.1_Missense_Mutation_p.D385N|PARD3B_ENST00000351153.1_Missense_Mutation_p.D385N|PARD3B_ENST00000349953.3_Missense_Mutation_p.D385N|PARD3B_ENST00000358768.2_Missense_Mutation_p.D385N	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	385	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AATTAAGATTGACCTAAAGAA	0.358000													12	45					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25472176	25472176	+	RNA	SNP	C	C	T	rs1883006	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:25472176C>T	ENST00000453082.2	+	0	1218					NR_003343.1																						CTAGTGCCCTCGGCTCCTGCA	0.607000													5	92					0	0	1	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90122045	90122045	+	RNA	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:90122045G>C	ENST00000483379.1	+	0	444																											AGCGGCAGTGGATCTGGGACA	0.478000													50	120					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	24					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237604716	237604716	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:237604716C>A	ENST00000366574.2	+	13	1420	c.1103C>A	c.(1102-1104)aCa>aAa	p.T368K	RYR2_ENST00000360064.6_Missense_Mutation_p.T366K|RYR2_ENST00000542537.1_Missense_Mutation_p.T352K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	368	MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATGTAGACACAGGCCTATGG	0.378000													43	99					1.52319e-26	2.68234e-26	1	1	0
PHF2	5253	broad.mit.edu	37	9	96392313	96392313	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:96392313G>T	ENST00000359246.4	+	2	527	c.160G>T	c.(160-162)Gag>Tag	p.E54*	PHF2_ENST00000375376.4_Nonsense_Mutation_p.E54*	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	54					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CCCAAACTGTGAGAAAACCCA	0.567000													12	58					1.61879e-10	2.08556e-10	1	1	0
NELL2	4753	broad.mit.edu	37	12	45209899	45209899	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:45209899C>A	ENST00000429094.2	-	3	709	c.205G>T	c.(205-207)Gca>Tca	p.A69S	NELL2_ENST00000549027.1_Missense_Mutation_p.A68S|NELL2_ENST00000547172.1_5'UTR|NELL2_ENST00000395487.2_Missense_Mutation_p.A68S|NELL2_ENST00000437801.2_Missense_Mutation_p.A119S|NELL2_ENST00000452445.2_Missense_Mutation_p.A69S|NELL2_ENST00000551601.1_Missense_Mutation_p.A68S|NELL2_ENST00000548826.1_Missense_Mutation_p.A69S|NELL2_ENST00000333837.4_Missense_Mutation_p.A92S	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	69	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GCAGTGGATGCTTTTATGCTT	0.308000													42	196					8.01111e-26	1.40487e-25	1	1	0
USP9X	8239	broad.mit.edu	37	X	41010268	41010268	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:41010268G>C	ENST00000324545.7	+	13	2354	c.1721G>C	c.(1720-1722)aGa>aCa	p.R574T	USP9X_ENST00000378308.2_Missense_Mutation_p.R574T	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	574					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						AAACAAATTAGAGAAATTTGT	0.313000													15	5					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78268764	78268764	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:78268764G>T	ENST00000582970.1	+	9	1860	c.1717G>T	c.(1717-1719)Gca>Tca	p.A573S	RNF213_ENST00000319921.4_Missense_Mutation_p.A573S|RNF213_ENST00000456466.1_Missense_Mutation_p.A573S|RNF213_ENST00000508628.2_Missense_Mutation_p.A622S	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	573										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGAAGGACAGGCACAGCTGTG	0.537000													22	44					1.64293e-13	2.29628e-13	1	1	0
KCNE2	9992	broad.mit.edu	37	21	35742928	35742928	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:35742928C>A	ENST00000290310.2	+	2	291	c.151C>A	c.(151-153)Ctg>Atg	p.L51M		NM_172201.1	NP_751951.1	Q9Y6J6	KCNE2_HUMAN	potassium voltage-gated channel, Isk-related family, member 2	51					blood circulation|muscle contraction|regulation of heart contraction	lysosome|voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(1)	2						CTATGTCATCCTGTACCTCAT	0.458000													20	78					4.96729e-08	6.02096e-08	1	1	0
MAMLD1	10046	broad.mit.edu	37	X	149639081	149639081	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:149639081C>A	ENST00000370401.2	+	4	1546	c.1236C>A	c.(1234-1236)agC>agA	p.S412R	MAMLD1_ENST00000432680.2_Missense_Mutation_p.S387R|MAMLD1_ENST00000262858.5_Missense_Mutation_p.S412R|MAMLD1_ENST00000426613.2_Missense_Mutation_p.S387R			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	412					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					AGCTCCCCAGCCCTGCTCTCA	0.587000													151	87					2.39329e-74	4.84425e-74	1	1	0
DAPK1	1612	broad.mit.edu	37	9	90263781	90263781	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:90263781A>C	ENST00000469640.2	+	15	1790	c.1415A>C	c.(1414-1416)aAt>aCt	p.N472T	DAPK1_ENST00000491893.1_Missense_Mutation_p.N472T|DAPK1_ENST00000408954.3_Missense_Mutation_p.N472T|DAPK1_ENST00000472284.1_Missense_Mutation_p.N472T|DAPK1_ENST00000358077.5_Missense_Mutation_p.N472T			P53355	DAPK1_HUMAN	death-associated protein kinase 1	472					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TCAAATCCCAATATCCAGGAC	0.537000									Chronic Lymphocytic Leukemia, Familial Clustering of				23	58					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346450	70346450	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:70346450G>T	ENST00000305107.6	-	6	1535	c.1489C>A	c.(1489-1491)Ctg>Atg	p.L497M	UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.L361M|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	497					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CAGGCCAGCAGGAACCCAGTC	0.463000													37	129					5.8336e-16	8.59689e-16	1	1	0
LEPR	3953	broad.mit.edu	37	1	66102072	66102072	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:66102072C>T	ENST00000349533.6	+	20	3057	c.2872C>T	c.(2872-2874)Cag>Tag	p.Q958*	LEPR_ENST00000406510.3_Nonsense_Mutation_p.Q25*	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	958					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TATTAGTGACCAGTTCAACAG	0.418000													50	97					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128429069	128429069	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:128429069G>T	ENST00000465342.2	+	2	2115	c.958G>T	c.(958-960)Ggt>Tgt	p.G320C	CASC8_ENST00000523825.1_RNA|CASC8_ENST00000502082.1_RNA|POU5F1B_ENST00000391675.1_Missense_Mutation_p.G320C|CASC8_ENST00000501396.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	320						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						GCCCCATTTTGGTACCCCAGG	0.582000													9	23					0.000673444	0.000717884	1	1	0
PDP1	54704	broad.mit.edu	37	8	94934695	94934695	+	Silent	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:94934695A>G	ENST00000396200.3	+	3	759	c.483A>G	c.(481-483)agA>agG	p.R161R	PDP1_ENST00000520728.1_Silent_p.R136R|PDP1_ENST00000517764.1_Silent_p.R136R|PDP1_ENST00000297598.4_Silent_p.R136R	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	136					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						TGCAGACCAGAGGGATGCTTT	0.478000													33	221					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62172680	62172680	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:62172680G>T	ENST00000217188.1	-	7	1189	c.1149C>A	c.(1147-1149)agC>agA	p.S383R		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	383	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			TGGAGCTGCTGCTCGGGGAGT	0.662000													238	64					7.25459e-121	1.48269e-120	1	1	0
FAM9C	171484	broad.mit.edu	37	X	13061295	13061295	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:13061295T>A	ENST00000542843.1	-	3	344	c.134A>T	c.(133-135)gAt>gTt	p.D45V	FAM9C_ENST00000380625.3_Missense_Mutation_p.D45V|FAM9C_ENST00000333995.3_Missense_Mutation_p.D45V			Q8IZT9	FAM9C_HUMAN	family with sequence similarity 9, member C	45						nucleus				NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(1)	5						CCCATGCTCATCAGTTACATC	0.398000													107	101					0	0	1	0	0
RIMKLB	57494	broad.mit.edu	37	12	8904555	8904555	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:8904555G>T	ENST00000357529.3	+	5	1671	c.409G>T	c.(409-411)Ggc>Tgc	p.G137C	RIMKLB_ENST00000538135.1_Missense_Mutation_p.G137C|RIMKLB_ENST00000299673.5_3'UTR|RIMKLB_ENST00000535829.1_Missense_Mutation_p.G137C	NM_020734.2	NP_065785.2	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family member B	137	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CAAACCAGGTGGCCACGAAAA	0.388000													25	97					3.7963e-18	5.84047e-18	1	1	0
SERPINB4	6318	broad.mit.edu	37	18	61309072	61309072	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:61309072T>C	ENST00000341074.5	-	4	388	c.273A>G	c.(271-273)gaA>gaG	p.E91E	SERPINB4_ENST00000356424.6_Silent_p.E91E	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						ATTTGTTGAATTCAGTCAGAA	0.383000													46	128					0	0	1	0	0
HUS1	3364	broad.mit.edu	37	7	48015209	48015209	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:48015209C>A	ENST00000258774.5	-	5	564		c.e5+1		HUS1_ENST00000432325.1_Splice_Site	NM_004507.3	NP_004498.1	O60921	HUS1_HUMAN	HUS1 checkpoint homolog (S. pombe)						DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|prostate(1)	13		Breast(660;0.00139)				TTGTGACTTACAAGGTGATTG	0.423000								Direct reversal of damage;Other conserved DNA damage response genes					8	30					2.17888e-05	2.43709e-05	1	1	0
THADA	63892	broad.mit.edu	37	2	43571345	43571345	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:43571345G>T	ENST00000405006.4	-	30	4610	c.4259C>A	c.(4258-4260)tCc>tAc	p.S1420Y	THADA_ENST00000330266.7_Intron|THADA_ENST00000405975.2_Missense_Mutation_p.S1420Y|THADA_ENST00000415080.2_Missense_Mutation_p.S1101Y|THADA_ENST00000485353.1_5'UTR	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1420							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TCCGTGTTTGGAGTCTGAGTA	0.403000													17	10					0.00498961	0.00518722	1	1	0
MACF1	23499	broad.mit.edu	37	1	39800894	39800894	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:39800894G>T	ENST00000564288.1	+	37	9411	c.8634G>T	c.(8632-8634)ttG>ttT	p.L2878F	MACF1_ENST00000372915.3_Missense_Mutation_p.L2883F|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.L2915F|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.L1318F|MACF1_ENST00000317713.7_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2883					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTAAATCCTTGGGCCAAGTGT	0.358000													6	76					8.12818e-05	8.8902e-05	1	1	0
PCK1	5105	broad.mit.edu	37	20	56136537	56136537	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:56136537C>A	ENST00000319441.4	+	2	234	c.70C>A	c.(70-72)Ccc>Acc	p.P24T	PCK1_ENST00000543666.1_5'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	24					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGACAGCCTACCCCAGGCAGT	0.567000													52	228					9.57592e-29	1.72984e-28	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144882556	144882556	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:144882556C>A	ENST00000369359.4	-	27	3912	c.3874G>T	c.(3874-3876)Ggt>Tgt	p.G1292C	PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.G1292C|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.G1155C|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.G1155C|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1155					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCAGGGGAACCAACCAGTTCT	0.512000			T	PDGFRB	MPD								70	193					6.5469e-37	1.25844e-36	1	1	0
PCDH17	27253	broad.mit.edu	37	13	58299167	58299167	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:58299167C>T	ENST00000377918.3	+	4	3245	c.3219C>T	c.(3217-3219)ccC>ccT	p.P1073P		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1073					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGTACTTGCCCACTGACAGTC	0.532000													31	82					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73043431	73043431	+	RNA	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:73043431A>T	ENST00000604411.1	+	0	31392				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TCTGTAGGCCAGGTCAAGGTG	0.368000													26	76					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10158050	10158050	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:10158050C>A	ENST00000495140.1	+	0	1258																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						TCTTTGTGGACCTTAAGTTGC	0.532000													59	65					5.12918e-33	9.5321e-33	1	1	0
ST3GAL3	6487	broad.mit.edu	37	1	44257803	44257803	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:44257803G>T	ENST00000262915.3	+	3	371	c.194G>T	c.(193-195)gGa>gTa	p.G65V	ST3GAL3_ENST00000372377.4_Missense_Mutation_p.G50V|ST3GAL3_ENST00000372372.2_Intron|ST3GAL3_ENST00000372367.1_Intron|ST3GAL3_ENST00000361812.4_Missense_Mutation_p.G65V|ST3GAL3_ENST00000347631.2_Missense_Mutation_p.G65V|ST3GAL3_ENST00000353126.3_Missense_Mutation_p.G50V|ST3GAL3_ENST00000361746.4_Missense_Mutation_p.G65V|ST3GAL3_ENST00000372365.1_Missense_Mutation_p.G50V|ST3GAL3_ENST00000528371.1_Intron|ST3GAL3_ENST00000531451.1_Intron|ST3GAL3_ENST00000545417.1_Missense_Mutation_p.G65V|ST3GAL3_ENST00000531993.1_Intron|ST3GAL3_ENST00000533933.1_Missense_Mutation_p.G50V|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000372362.2_Missense_Mutation_p.G50V|ST3GAL3_ENST00000361392.4_Missense_Mutation_p.G50V|ST3GAL3_ENST00000372369.1_Missense_Mutation_p.G50V|ST3GAL3_ENST00000372366.1_Intron|ST3GAL3_ENST00000372368.2_Missense_Mutation_p.G50V|ST3GAL3_ENST00000372375.2_Missense_Mutation_p.G50V|ST3GAL3_ENST00000335430.6_Intron|ST3GAL3_ENST00000372374.2_Missense_Mutation_p.G50V|ST3GAL3_ENST00000351035.3_Intron|ST3GAL3_ENST00000361400.4_Intron|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000330208.2_Missense_Mutation_p.G50V|ST3GAL3_ENST00000332628.6_Missense_Mutation_p.G50V	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	50					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GACTCCGCTGGACAAACACTA	0.413000													48	120					1.39843e-22	2.31236e-22	1	1	0
GRIN2B	2904	broad.mit.edu	37	12	13715933	13715933	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:13715933C>A	ENST00000279593.3	-	13	4448	c.4239G>T	c.(4237-4239)ggG>ggT	p.G1413G		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1413					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTTCGACGCCCCCGCCACCG	0.622000													10	41					0.000442599	0.000476645	1	1	0
RNF20	56254	broad.mit.edu	37	9	104303159	104303159	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:104303159G>T	ENST00000389120.3	+	5	620	c.530G>T	c.(529-531)cGt>cTt	p.R177L		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	177					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		CTGCAGGAACGTGTGGAGTCT	0.522000													13	72					4.3838e-07	5.12868e-07	1	1	0
RYR2	6262	broad.mit.edu	37	1	237880513	237880513	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:237880513C>G	ENST00000366574.2	+	72	10656	c.10339C>G	c.(10339-10341)Cag>Gag	p.Q3447E	RYR2_ENST00000360064.6_Missense_Mutation_p.Q3445E|RYR2_ENST00000542537.1_Missense_Mutation_p.Q3431E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3447					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTCTGATCAGGAAAGGAA	0.458000													31	21					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92613977	92613977	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:92613977C>T	ENST00000298047.6	+	22	12225	c.12208C>T	c.(12208-12210)Cgg>Tgg	p.R4070W	FAT3_ENST00000525166.1_Missense_Mutation_p.R3920W|FAT3_ENST00000409404.2_Missense_Mutation_p.R4070W|FAT3_ENST00000533797.1_Missense_Mutation_p.R405W			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4070	EGF-like 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAACCCCTGCCGGAATGGAGG	0.483000										TCGA Ovarian(4;0.039)			54	323					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47667250	47667250	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:47667250C>G	ENST00000273857.4	-	11	1387	c.1388G>C	c.(1387-1389)tGc>tCc	p.C463S	CORIN_ENST00000502252.1_Missense_Mutation_p.C396S|CORIN_ENST00000505909.1_Missense_Mutation_p.C426S|CORIN_ENST00000504584.1_Missense_Mutation_p.C426S|CORIN_ENST00000508498.1_Missense_Mutation_p.C324S	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	463	FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CAAATTCATGCAGAGTTCCAA	0.343000													34	127					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981642	70981642	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:70981642G>T	ENST00000276594.2	-	2	655	c.454C>A	c.(454-456)Ccg>Acg	p.P152T		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GCAGGGGGCGGTGGAATTAAA	0.577000													7	130					5.18039e-06	5.89638e-06	1	1	0
TLR4	7099	broad.mit.edu	37	9	120475913	120475913	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:120475913C>A	ENST00000355622.6	+	3	1608	c.1507C>A	c.(1507-1509)Ctc>Atc	p.L503I	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.L463I	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	503					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTTCCTGGACCTCTCTCAGTG	0.438000													39	130					2.54651e-27	4.52234e-27	1	1	0
ABCA12	26154	broad.mit.edu	37	2	215843578	215843578	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:215843578C>A	ENST00000272895.7	-	32	5146	c.4927G>T	c.(4927-4929)Ggt>Tgt	p.G1643C	ABCA12_ENST00000389661.4_Missense_Mutation_p.G1325C	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1643					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTGAGGTCACCCATGCCATTG	0.478000													95	51					4.22297e-61	8.50671e-61	1	1	0
WAPAL	23063	broad.mit.edu	37	10	88213072	88213072	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:88213072C>T	ENST00000298767.5	-	14	3326	c.2854G>A	c.(2854-2856)Gga>Aga	p.G952R	WAPAL_ENST00000263070.7_Missense_Mutation_p.G219R|WAPAL_ENST00000372075.1_Missense_Mutation_p.G219R	NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	952	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						TCCTGCTCTCCTGTTTTGGTG	0.433000													18	84					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003342	52003342	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:52003342C>A	ENST00000291707.3	-	2	695	c.640G>T	c.(640-642)Gag>Tag	p.E214*	SIGLEC12_ENST00000598614.1_Nonsense_Mutation_p.E96*	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	214	Ig-like V-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGGGTATCCTCTTGCACTTTT	0.537000													66	67					6.26901e-30	1.13982e-29	1	1	0
CUEDC1	404093	broad.mit.edu	37	17	55962795	55962795	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:55962795C>A	ENST00000577830.1	-	2	544	c.131G>T	c.(130-132)cGc>cTc	p.R44L	CUEDC1_ENST00000407144.2_Missense_Mutation_p.R44L|CUEDC1_ENST00000360238.2_Missense_Mutation_p.R44L|CUEDC1_ENST00000577840.1_Intron	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	44										endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						GAACTCCAGGCGGCGCACCTG	0.701000													31	28					1.13719e-10	1.47186e-10	1	1	0
CNTN5	53942	broad.mit.edu	37	11	99690497	99690497	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:99690497G>A	ENST00000524871.1	+	4	567		c.e4+1		CNTN5_ENST00000418526.2_Intron|CNTN5_ENST00000528682.1_Splice_Site|CNTN5_ENST00000279463.3_Splice_Site|CNTN5_ENST00000527185.1_Splice_Site	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5						cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAACAAGATGGTAAGtgtcaa	0.418000													3	5					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23283313	23283313	+	RNA	SNP	C	C	A	rs145817269	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:23283313C>A	ENST00000560464.1	-	0	5097																											ACCGCCGCAGCGTGTGCCTTT	0.453000													10	83					0.000442599	0.000476645	1	1	0
EFNA5	1946	broad.mit.edu	37	5	106762991	106762991	+	Silent	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:106762991A>G	ENST00000333274.6	-	2	626	c.345T>C	c.(343-345)tcT>tcC	p.S115S	EFNA5_ENST00000509503.1_Silent_p.S115S	NM_001962.2	NP_001953.1	P52803	EFNA5_HUMAN	ephrin-A5	115					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding			large_intestine(6)	6		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		GGAATTTTTCAGAGAACTTCA	0.448000													19	87					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40696557	40696557	+	Silent	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:40696557G>C	ENST00000454349.2	+	13	4018	c.3807G>C	c.(3805-3807)ctG>ctC	p.L1269L	TNRC6B_ENST00000402203.1_Silent_p.L465L|TNRC6B_ENST00000301923.9_Silent_p.L465L|TNRC6B_ENST00000335727.8_Silent_p.L1159L	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1269					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						TTGCCATGCTGAGCCAGCTTC	0.433000													12	19					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59224473	59224473	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:59224473T>C	ENST00000300127.2	+	1	63	c.40T>C	c.(40-42)Ttc>Ctc	p.F14L		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						GGAGTTTTTCTTCCTGGAACT	0.433000													90	107					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99942489	99942489	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:99942489C>A	ENST00000524871.1	+	12	1642	c.1352C>A	c.(1351-1353)tCa>tAa	p.S451*	CNTN5_ENST00000418526.2_Nonsense_Mutation_p.S377*|CNTN5_ENST00000528682.1_Nonsense_Mutation_p.S451*|CNTN5_ENST00000279463.3_Nonsense_Mutation_p.S451*|CNTN5_ENST00000527185.1_Nonsense_Mutation_p.S451*	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	451	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGAATCAATCAGATGCTGGA	0.343000													9	14					3.09899e-07	3.6664e-07	1	1	0
MYCBP2	23077	broad.mit.edu	37	13	77692590	77692590	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:77692590T>A	ENST00000360084.5	-	57	8183	c.480A>T	c.(478-480)cgA>cgT	p.R160R	MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000544440.2_Intron|MYCBP2_ENST00000407578.2_Intron|MYCBP2_ENST00000357337.6_Intron			O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGAGATTGGGTCGTGACTGAA	0.463000													12	13					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22678195	22678195	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:22678195T>C	ENST00000376603.2	+	7	1329	c.1187T>C	c.(1186-1188)gTa>gCa	p.V396A	SPAG6_ENST00000313311.6_Missense_Mutation_p.V320A|SPAG6_ENST00000376624.3_Missense_Mutation_p.V320A|SPAG6_ENST00000376601.1_Intron|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000538630.1_Missense_Mutation_p.V295A			O75602	SPAG6_HUMAN	sperm associated antigen 6	320					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						CTTGGTTATGTAGCAGCTCAT	0.473000													63	44					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32196546	32196546	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:32196546T>A	ENST00000373658.3	-	29	4576	c.4235A>T	c.(4234-4236)tAt>tTt	p.Y1412F	BAI2_ENST00000398556.3_Missense_Mutation_p.Y1327F|BAI2_ENST00000440175.2_Missense_Mutation_p.Y1021F|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398538.1_Missense_Mutation_p.Y1400F|BAI2_ENST00000398542.1_Missense_Mutation_p.Y1312F|BAI2_ENST00000398547.1_Missense_Mutation_p.Y1345F|BAI2_ENST00000373655.2_Missense_Mutation_p.Y1412F|BAI2_ENST00000527361.1_Missense_Mutation_p.Y1379F|BAI2_ENST00000257070.4_Missense_Mutation_p.Y1379F	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1412					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GAGAGATCCATAGGCAGGGCC	0.682000													10	40					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540381	169540381	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:169540381C>A	ENST00000340806.6	+	1	672	c.672C>A	c.(670-672)ccC>ccA	p.P224P		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	224										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACAACCTTCCCGTTCTGCCCG	0.537000													53	77					1.51926e-22	2.49741e-22	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8492932	8492932	+	Silent	SNP	G	G	A	rs145034888		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:8492932G>A	ENST00000381196.4	-	24	2940	c.2397C>T	c.(2395-2397)acC>acT	p.T799T	PTPRD_ENST00000358503.5_Silent_p.T777T|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000540109.1_Silent_p.T799T|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000356435.5_Silent_p.T799T|PTPRD_ENST00000360074.4_Silent_p.T786T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	799	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGGCTGTGACGGTGAGGGAGT	0.483000										TSP Lung(15;0.13)			32	82					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256860	63256860	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:63256860C>T	ENST00000323865.3	-	1	920	c.687G>A	c.(685-687)acG>acA	p.T229T	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	229					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CCTTTTTGACCGTCTTGCGGA	0.582000													50	55					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38645254	38645254	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:38645254G>T	ENST00000413689.1	-	12	2032	c.1839C>A	c.(1837-1839)tcC>tcA	p.S613S	SCN5A_ENST00000333535.4_Silent_p.S613S|SCN5A_ENST00000425664.1_Silent_p.S613S|SCN5A_ENST00000455624.2_Silent_p.S613S|SCN5A_ENST00000451551.2_Silent_p.S613S|SCN5A_ENST00000450102.2_Silent_p.S613S|SCN5A_ENST00000449557.2_Silent_p.S613S|SCN5A_ENST00000443581.1_Silent_p.S613S|SCN5A_ENST00000423572.2_Silent_p.S613S|SCN5A_ENST00000414099.2_Silent_p.S613S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	613					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGCTTCCTGGGGATGTGGCCT	0.637000													22	41					1.55795e-14	2.2106e-14	1	1	0
ATF7IP	55729	broad.mit.edu	37	12	14577246	14577246	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:14577246G>C	ENST00000544627.1	+	2	741	c.421G>C	c.(421-423)Gat>Cat	p.D141H	ATF7IP_ENST00000540793.1_Missense_Mutation_p.D133H|ATF7IP_ENST00000261168.4_Missense_Mutation_p.D133H|ATF7IP_ENST00000543189.1_Missense_Mutation_p.D133H|ATF7IP_ENST00000536444.1_Missense_Mutation_p.D133H|ATF7IP_ENST00000541654.1_3'UTR			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	133					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						AGTTTCTGGTGATCCAGCCCC	0.507000													18	40					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20986733	20986733	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:20986733G>T	ENST00000261383.3	-	51	8080	c.8081C>A	c.(8080-8082)gCg>gAg	p.A2694E	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2694	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.A2694V(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTGCATAACCGCTACCTAGCA	0.458000													67	51					9.64103e-21	1.53963e-20	1	1	0
SNTG1	54212	broad.mit.edu	37	8	51465654	51465654	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:51465654G>T	ENST00000522124.1	+	12	1386	c.725G>T	c.(724-726)gGg>gTg	p.G242V	SNTG1_ENST00000518864.1_Missense_Mutation_p.G242V|SNTG1_ENST00000517473.1_Missense_Mutation_p.G242V|SNTG1_ENST00000276467.5_Missense_Mutation_p.G242V	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	242					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding	p.G242V(1)		NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTCTGCACTGGGATTATTCAG	0.418000													60	128					1.14385e-22	1.89889e-22	1	1	0
DET1	55070	broad.mit.edu	37	15	89056202	89056202	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:89056202T>A	ENST00000564406.1	-	6	1826	c.1666A>T	c.(1666-1668)Atg>Ttg	p.M556L	DET1_ENST00000444300.1_Missense_Mutation_p.M556L|DET1_ENST00000268148.8_Missense_Mutation_p.M545L	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	545						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CAGTGTCGCATATGGAAGTTG	0.493000													26	22					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25570186	25570186	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:25570186T>A	ENST00000269141.3	-	10	1896	c.1473A>T	c.(1471-1473)gtA>gtT	p.V491V	CDH2_ENST00000399380.3_Silent_p.V460V	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	491	Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GGTTTTCATTTACGTCAATAA	0.468000													83	98					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32621290	32621290	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:32621290G>T	ENST00000338921.4	+	13	1834	c.1317G>T	c.(1315-1317)ccG>ccT	p.P439P	NRG1_ENST00000287845.5_Silent_p.P402P|NRG1_ENST00000405005.2_Silent_p.P431P|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000539990.1_Silent_p.P274P|NRG1_ENST00000521670.1_3'UTR|NRG1_ENST00000356819.4_Silent_p.P436P|NRG1_ENST00000519301.1_Silent_p.P381P|NRG1_ENST00000287842.3_Silent_p.P428P|NRG1_ENST00000287840.5_Silent_p.P431P			Q02297	NRG1_HUMAN	neuregulin 1	431					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGACCACCCCGGCTCGTATGT	0.547000													24	65					9.57634e-11	1.24138e-10	1	1	0
PGK2	5232	broad.mit.edu	37	6	49753711	49753711	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:49753711C>T	ENST00000304801.3	-	1	1342	c.1190G>A	c.(1189-1191)gGt>gAt	p.G397D		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	397					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TAGACTGGCACCGCCTCCAGT	0.478000													52	87					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95712167	95712167	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:95712167T>C	ENST00000524717.1	-	5	4700	c.3416A>G	c.(3415-3417)aAt>aGt	p.N1139S		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	1139					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCAGTCATCATTACCAGGCTC	0.388000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								7	80					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89890145	89890145	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:89890145C>A	ENST00000435811.1	-	8	1415	c.961G>T	c.(961-963)Gtc>Ttc	p.V321F	GABRR1_ENST00000454853.2_Missense_Mutation_p.V338F|GABRR1_ENST00000369451.3_Missense_Mutation_p.V251F	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	338					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	ATGTAGGAGACGCGCGGCATG	0.537000													36	31					3.93418e-24	6.70327e-24	1	1	0
MDGA2	161357	broad.mit.edu	37	14	47311201	47311201	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr14:47311201C>A	ENST00000426342.1	-	17	2863	c.2117G>T	c.(2116-2118)gGg>gTg	p.G706V	MDGA2_ENST00000399222.3_Missense_Mutation_p.G137V|MDGA2_ENST00000439988.2_Missense_Mutation_p.G935V|MDGA2_ENST00000357362.3_Missense_Mutation_p.G706V|MDGA2_ENST00000399232.2_Missense_Mutation_p.G1004V	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	935					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						AACCAAAATCCCAACAGCACC	0.383000													22	23					1.50039e-11	1.9879e-11	1	1	0
SERPINE1	5054	broad.mit.edu	37	7	100771831	100771831	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:100771831C>A	ENST00000223095.4	+	2	314	c.157C>A	c.(157-159)Cgc>Agc	p.R53S	SERPINE1_ENST00000445463.2_Missense_Mutation_p.R38S	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	53				R -> A (in Ref. 7; CAA31208).	angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	CTCCAAGGACCGCAACGTGGT	0.607000													22	42					2.27731e-05	2.54042e-05	1	1	0
MSI2	124540	broad.mit.edu	37	17	55478757	55478757	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:55478757G>T	ENST00000284073.2	+	6	539	c.330G>T	c.(328-330)aaG>aaT	p.K110N	MSI2_ENST00000579180.1_Missense_Mutation_p.K6N|MSI2_ENST00000322684.3_Missense_Mutation_p.K106N|MSI2_ENST00000442934.2_Missense_Mutation_p.K49N|MSI2_ENST00000416426.2_Missense_Mutation_p.K88N	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	110	RRM 1.|RRM 2.					cytoplasm	nucleotide binding|RNA binding	p.K106K(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		CAAGAACAAAGAAAATATTTG	0.448000			T	HOXA9	CML								10	108					0.010729	0.011099	1	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89104958	89104958	+	RNA	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:89104958A>G	ENST00000393525.3	+	0	4898																											AATTCAAATCATTGATTTCTG	0.289000													3	10					0	0	1	0	0
B3GNT7	93010	broad.mit.edu	37	2	232263211	232263211	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:232263211G>T	ENST00000287590.5	+	2	1042	c.781G>T	c.(781-783)Gaa>Taa	p.E261*		NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	261					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		GCAGCCACAGGAAAACCTGTT	0.572000													14	44					4.36969e-10	5.54462e-10	1	1	0
HRG	3273	broad.mit.edu	37	3	186395251	186395251	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:186395251C>A	ENST00000232003.4	+	7	1237	c.1157C>A	c.(1156-1158)cCc>cAc	p.P386H		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	386	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		ggacaccacccccatggacac	0.542000													12	18					1.08611e-07	1.30519e-07	1	1	0
ACTRT1	139741	broad.mit.edu	37	X	127185199	127185199	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:127185199C>G	ENST00000371124.3	-	1	1183	c.987G>C	c.(985-987)aaG>aaC	p.K329N		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	329						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						AAGCTGTGATCTTGATGGGAG	0.527000													68	49					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64361183	64361183	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:64361183C>A	ENST00000377574.1	+	4	1485	c.738C>A	c.(736-738)ggC>ggA	p.G246G	SLC22A12_ENST00000377572.1_Intron|SLC22A12_ENST00000473690.1_Silent_p.G25G|SLC22A12_ENST00000336464.7_Silent_p.G212G|SLC22A12_ENST00000377567.2_Intron	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	246					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						TCGGCCATGGCCTGACAGCTG	0.617000													21	54					3.62473e-10	4.60632e-10	1	1	0
GJA9	81025	broad.mit.edu	37	1	39340731	39340731	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:39340731C>T	ENST00000454994.2	-	2	1316	c.1040G>A	c.(1039-1041)aGt>aAt	p.S347N	MYCBP_ENST00000489803.1_5'UTR|RP5-864K19.4_ENST00000443161.1_RNA|RP5-864K19.4_ENST00000433671.2_RNA|GJA9_ENST00000357771.3_Missense_Mutation_p.S347N|GJA9_ENST00000360786.3_Missense_Mutation_p.S347N|RP5-864K19.4_ENST00000456813.1_RNA			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	347					cell communication	connexon complex|integral to membrane				breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			ATTGTTTGAACTGATGTGTTG	0.323000													38	46					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39448103	39448103	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:39448103T>C	ENST00000257408.4	+	4	1854	c.1757T>C	c.(1756-1758)cTt>cCt	p.L586P		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	586	Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						AAAAAACAACTTGAGATGTTG	0.532000													24	104					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171260812	171260812	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:171260812G>T	ENST00000334231.6	+	20	2360	c.2360G>T	c.(2359-2361)cGc>cTc	p.R787L	MYO3B_ENST00000408978.4_Missense_Mutation_p.R778L|MYO3B_ENST00000409044.3_Missense_Mutation_p.R778L|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	778	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GAGGACAACCGCCCGCTCTTG	0.507000													48	57					2.17451e-35	4.12323e-35	1	1	0
ZFP64	55734	broad.mit.edu	37	20	50713957	50713957	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:50713957C>T	ENST00000361387.2	-	7	991	c.931G>A	c.(931-933)Gtc>Atc	p.V311I	ZFP64_ENST00000477786.1_5'UTR|ZFP64_ENST00000371518.2_Missense_Mutation_p.V311I|ZFP64_ENST00000371523.4_Missense_Mutation_p.V92I	NM_199427.2	NP_955459.2	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						ATGCCATGGACAGTTTTGAAG	0.438000													69	485					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579031	54579031	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:54579031G>T	ENST00000064571.2	-	1	1497	c.197C>A	c.(196-198)gCg>gAg	p.A66E		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	66	C1q.					cell junction|extracellular region|synapse		p.A66V(1)		endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			GGAGTTGGCCGCCCGGACCGA	0.627000													27	241					6.12954e-19	9.5881e-19	1	1	0
TRPM1	4308	broad.mit.edu	37	15	31362160	31362160	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:31362160A>T	ENST00000559179.1	-	3	420	c.287T>A	c.(286-288)cTg>cAg	p.L96Q	TRPM1_ENST00000397795.2_Intron|TRPM1_ENST00000256552.6_Intron|TRPM1_ENST00000542188.1_Intron	NM_001252030.1	NP_001238959.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1381					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGGTATCTGCAGTTTGGGGCT	0.473000													113	131					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55614831	55614831	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:55614831G>A	ENST00000326258.1	+	1	23	c.23G>A	c.(22-24)aGa>aAa	p.R8K		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						AATCACACCAGAGTCACTGAA	0.343000													36	124					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578257	7578257	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:7578257C>A	ENST00000420246.2	-	6	724	c.592G>T	c.(592-594)Gaa>Taa	p.E198*	TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.E198*|TP53_ENST00000413465.2_Nonsense_Mutation_p.E198*|TP53_ENST00000455263.2_Nonsense_Mutation_p.E198*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E198*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E198*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	198	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		E -> D (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E198*(27)|p.0?(8)|p.E198K(5)|p.?(5)|p.P191_E198>Q(3)|p.E105*(3)|p.E66*(3)|p.E198fs*11(2)|p.E198Q(2)|p.E198fs*7(1)|p.E198fs*49(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAATTTCCTTCCACTCGGATA	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	14					3.32936e-07	3.92239e-07	1	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140751466	140751466	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:140751466C>T	ENST00000576222.1	+	1	1636	c.1505C>T	c.(1504-1506)tCg>tTg	p.S502L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGAGCTGTCGTCCTACGTG	0.657000													90	58					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125061921	125061921	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:125061921C>G	ENST00000522917.1	+	22	3004	c.2798C>G	c.(2797-2799)cCc>cGc	p.P933R	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6-AS2_ENST00000601180.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.P933R	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	933						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TATGAGCCCCCCAGGTTATGC	0.498000													14	153					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149751647	149751647	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:149751647C>T	ENST00000451292.1	+	7	826	c.718C>T	c.(718-720)Cca>Tca	p.P240S	TCOF1_ENST00000504761.2_Missense_Mutation_p.P240S|TCOF1_ENST00000445265.2_Intron|TCOF1_ENST00000394269.3_Missense_Mutation_p.P240S|TCOF1_ENST00000377797.3_Missense_Mutation_p.P240S|TCOF1_ENST00000513346.1_Missense_Mutation_p.P240S|TCOF1_ENST00000323668.7_Intron|TCOF1_ENST00000439160.2_Missense_Mutation_p.P240S			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	240					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGGCGGCCCCAGCCCCTGG	0.572000													6	53					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128488646	128488646	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:128488646G>A	ENST00000325888.8	+	27	4873	c.4612G>A	c.(4612-4614)Gat>Aat	p.D1538N	FLNC_ENST00000346177.6_Missense_Mutation_p.D1538N	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1538					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCCAGCTCATGATGCCAGCAA	0.642000													88	190					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457517	107457517	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:107457517C>A	ENST00000318763.5	+	1	858	c.815C>A	c.(814-816)aCc>aAc	p.T272N		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	272					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						GCCTTCTCTACCTGTTCAGCG	0.388000													24	90					9.95505e-16	1.45938e-15	1	1	0
MAGT1	84061	broad.mit.edu	37	X	77112883	77112883	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:77112883G>A	ENST00000358075.6	-	4	684	c.598C>T	c.(598-600)Cgg>Tgg	p.R200W		NM_032121.5	NP_115497.4	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	168					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				cervix(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	17						GCGATCCACCGGGCAATCTGC	0.463000													118	70					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480036	142480036	+	RNA	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142480036G>T	ENST00000603901.1	+	0	168					NR_001296.3																						TCAGCGAACAGTGGGTGGTGT	0.587000													26	141					2.70662e-09	3.36824e-09	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41419997	41419997	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:41419997G>T	ENST00000373198.3	-	3	559	c.324C>A	c.(322-324)taC>taA	p.Y108*	PTPRT_ENST00000356100.2_Nonsense_Mutation_p.Y108*|PTPRT_ENST00000373190.1_Nonsense_Mutation_p.Y108*|PTPRT_ENST00000373193.3_Nonsense_Mutation_p.Y108*|PTPRT_ENST00000373187.1_Nonsense_Mutation_p.Y108*|PTPRT_ENST00000373184.1_Nonsense_Mutation_p.Y108*|PTPRT_ENST00000373201.1_Nonsense_Mutation_p.Y108*	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	108	MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCTGGAGAAGTAGTAATGGA	0.587000													67	26					6.26901e-30	1.13982e-29	1	1	0
ZNF613	79898	broad.mit.edu	37	19	52443467	52443467	+	Silent	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:52443467A>T	ENST00000293471.6	+	4	700	c.21A>T	c.(19-21)tcA>tcT	p.S7S	ZNF613_ENST00000391794.4_5'UTR	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		TACAGGAATCACTGACCCTGG	0.448000													87	71					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57437115	57437115	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:57437115C>T	ENST00000442789.2	-	12	1207	c.920G>A	c.(919-921)gGc>gAc	p.G307D	MYO1A_ENST00000544473.1_Missense_Mutation_p.G145D|MYO1A_ENST00000300119.3_Missense_Mutation_p.G307D	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	307	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGAATTCAAGCCCACCATCTC	0.493000													19	45					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36752726	36752726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:36752726C>T	ENST00000354618.5	+	4	1119	c.895C>T	c.(895-897)Caa>Taa	p.Q299*	THRAP3_ENST00000469141.2_Nonsense_Mutation_p.Q299*	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	299	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGGACACACCAAGGTCAGTT	0.567000			T	USP6	aneurysmal bone cysts								22	67					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125315897	125315897	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:125315897G>A	ENST00000373688.2	+	1	507	c.449G>A	c.(448-450)aGc>aAc	p.S150N		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CTCCATTACAGCACATCTATG	0.537000													42	133					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175408	159175408	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:159175408C>A	ENST00000537147.1	+	3	1022	c.179C>A	c.(178-180)tCt>tAt	p.S60Y	DARC_ENST00000368121.2_Missense_Mutation_p.S62Y|DARC_ENST00000368122.2_Missense_Mutation_p.S60Y			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	60					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CTGGATGACTCTGCACTGCCC	0.537000													66	84					1.41401e-22	2.33065e-22	1	1	0
NCK2	8440	broad.mit.edu	37	2	106497818	106497818	+	Silent	SNP	G	G	A	rs138508918		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:106497818G>A	ENST00000233154.4	+	4	703	c.261G>A	c.(259-261)cgG>cgA	p.R87R	NCK2_ENST00000393349.2_Silent_p.R87R|NCK2_ENST00000451463.2_Intron|NCK2_ENST00000522586.1_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	87					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CCAGCGCGCGGGATGCGTCCC	0.677000													12	20					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927256	55927256	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:55927256C>T	ENST00000313447.1	-	1	537	c.538G>A	c.(538-540)Gat>Aat	p.D180N		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GGAACATCATCACAGTAAAAA	0.348000													20	101					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216538378	216538378	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:216538378T>G	ENST00000366943.2	-	4	1087	c.701A>C	c.(700-702)cAt>cCt	p.H234P	USH2A_ENST00000366942.3_Missense_Mutation_p.H234P|USH2A_ENST00000307340.3_Missense_Mutation_p.H234P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	234					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAAGGTGTATGATCCTTCTC	0.343000										HNSCC(13;0.011)			21	71					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132195453	132195453	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:132195453T>A	ENST00000360971.2	+	16	1631	c.1611T>A	c.(1609-1611)tcT>tcA	p.S537S		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	537	Phosphodiesterase.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTCATGGCTCTGACAATGTAT	0.274000													90	88					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71606527	71606527	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:71606527G>C	ENST00000355962.4	-	5	606	c.473C>G	c.(472-474)cCa>cGa	p.P158R	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	158					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GTTTTGCCCTGGGTTGGCCAA	0.438000													36	45					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67210805	67210805	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:67210805T>C	ENST00000290881.7	-	8	2251	c.1325A>G	c.(1324-1326)cAg>cGg	p.Q442R	KIAA0895L_ENST00000563902.1_Missense_Mutation_p.Q442R|KIAA0895L_ENST00000561679.1_Missense_Mutation_p.Q287R|KIAA0895L_ENST00000561621.1_3'UTR|KIAA0895L_ENST00000563831.2_5'UTR			Q68EN5	K895L_HUMAN	KIAA0895-like	442										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						TGCCAAGTCCTGCATGAAGTG	0.637000													29	125					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990877	990877	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:990877G>A	ENST00000190165.2	+	2	1329	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	431					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CCGCGCCACGGAAGACCCTCG	0.552000													16	46					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36348790	36348790	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:36348790T>C	ENST00000255448.4	-	18	2390	c.2179A>G	c.(2179-2181)Acc>Gcc	p.T727A	DCLK1_ENST00000379893.1_Missense_Mutation_p.N395S|DCLK1_ENST00000360631.3_Missense_Mutation_p.N702S	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	0					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CACATCCTGGTTGCGTCTTCG	0.552000													8	9					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73736141	73736141	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:73736141G>A	ENST00000377110.2	-	1	373	c.130C>T	c.(130-132)Cgg>Tgg	p.R44W	TRPM3_ENST00000357533.2_Intron|TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000377111.2_Missense_Mutation_p.R44W	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	44						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CACAGCTTCCGGATGGTCCAG	0.458000													14	53					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237951287	237951287	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:237951287G>T	ENST00000366574.2	+	92	13645		c.e92-1		RYR2_ENST00000360064.6_Splice_Site|RYR2_ENST00000542537.1_Splice_Site	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTTCATAGGGGAGAAGAT	0.403000													7	6					0.248553	0.250041	1	1	0
IFT172	26160	broad.mit.edu	37	2	27706463	27706463	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:27706463C>A	ENST00000260570.3	-	6	569	c.466G>T	c.(466-468)Gtg>Ttg	p.V156L	IFT172_ENST00000416524.2_Missense_Mutation_p.V135L|IFT172_ENST00000359466.6_Missense_Mutation_p.V156L	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	156					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTCAGGGACACCACGTAAGAC	0.403000													18	64					1.45105e-14	2.0659e-14	1	1	0
SPON2	10417	broad.mit.edu	37	4	1165770	1165770	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:1165770C>T	ENST00000290902.5	-	2	422	c.90G>A	c.(88-90)ggG>ggA	p.G30G	SPON2_ENST00000431380.1_Silent_p.G30G	NM_012445.3	NP_036577.1	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	30					axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|pancreas(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		TGGACTCTCCCCCAAGAGGCT	0.677000													21	46					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103907790	103907790	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:103907790G>T	ENST00000302259.3	+	1	483	c.240G>T	c.(238-240)gtG>gtT	p.V80V	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	80	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AGGACAATGTGGGACCTCGGG	0.607000													75	189					1.75807e-36	3.37164e-36	1	1	0
KRT6B	3854	broad.mit.edu	37	12	52845737	52845737	+	Missense_Mutation	SNP	C	C	A	rs150268236		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:52845737C>A	ENST00000252252.3	-	1	173	c.126G>T	c.(124-126)agG>agT	p.R42S		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	42	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CACCACTGCCCCTGGAGCGGG	0.672000													24	105					7.76418e-22	1.26394e-21	1	1	0
PLA2G4A	5321	broad.mit.edu	37	1	186957590	186957590	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:186957590G>T	ENST00000367466.3	+	18	2352	c.2200G>T	c.(2200-2202)Gag>Tag	p.E734*	PLA2G4A_ENST00000442353.2_Nonsense_Mutation_p.E674*	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	734	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TAGTAATGTTGAGGCAAGAAG	0.393000													60	105					5.19286e-32	9.60793e-32	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228522212	228522212	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:228522212G>T	ENST00000570156.2	+	71	18999		c.e71-1		OBSCN_ENST00000366709.4_Splice_Site|OBSCN_ENST00000366707.4_Splice_Site|OBSCN_ENST00000284548.11_Splice_Site|OBSCN_ENST00000422127.1_Splice_Site	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCTCTTTCAGGCCCTGATGA	0.657000													3	14					0.004672	0.00486908	1	1	0
GPC3	2719	broad.mit.edu	37	X	133087159	133087159	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:133087159T>A	ENST00000370818.3	-	2	700	c.255A>T	c.(253-255)gcA>gcT	p.A85A	GPC3_ENST00000394299.2_Silent_p.A85A|GPC3_ENST00000543339.1_Intron	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	85						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TGTTCAATCGTGCTGTTAGTT	0.418000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				66	180					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33461299	33461299	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:33461299C>G	ENST00000265112.3	+	13	1761	c.1450C>G	c.(1450-1452)Cgt>Ggt	p.R484G	TARS_ENST00000502553.1_Missense_Mutation_p.R484G|TARS_ENST00000541634.1_Missense_Mutation_p.R380G|TARS_ENST00000414361.2_Missense_Mutation_p.R363G|TARS_ENST00000455217.2_Missense_Mutation_p.R517G|TARS_ENST00000509410.1_3'UTR	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	484					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	GGATTTTCTACGTACGGTATA	0.318000													50	77					0	0	1	0	0
AGA	175	broad.mit.edu	37	4	178355548	178355548	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:178355548C>A	ENST00000264595.2	-	7	921	c.794G>T	c.(793-795)cGc>cTc	p.R265L	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	265					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		TGGCAGGAAGCGCATCAATAT	0.443000													33	104					6.53348e-20	1.03354e-19	1	1	0
PSAPL1	768239	broad.mit.edu	37	4	7435456	7435456	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:7435456G>C	ENST00000319098.4	-	1	1244	c.1151C>G	c.(1150-1152)tCc>tGc	p.S384C	SORCS2_ENST00000329016.9_Intron|SORCS2_ENST00000511199.1_Intron|SORCS2_ENST00000507866.2_Intron	NM_001085382.1	NP_001078851.1	Q6NUJ1	SAPL1_HUMAN	prosaposin-like 1 (gene/pseudogene)	384					sphingolipid metabolic process	extracellular region|lysosome				lung(4)	4						CCACTCTGGGGACGGCACGAT	0.612000													36	60					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496668	9496668	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:9496668A>G	ENST00000246070.2	+	3	751	c.259A>G	c.(259-261)Atc>Gtc	p.I87V	LAMP5_ENST00000427562.2_Intron	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	87						integral to membrane											ACAGGCCGATATCGCATTGAC	0.652000													8	3					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111776137	111776137	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:111776137G>T	ENST00000261726.6	+	20	3398	c.3244G>T	c.(3244-3246)Gtg>Ttg	p.V1082L		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1082						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						ACAGGGCTCCGTGTCTGACCT	0.622000													48	36					5.34276e-22	8.7144e-22	1	1	0
COL14A1	7373	broad.mit.edu	37	8	121239570	121239570	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:121239570G>A	ENST00000297848.3	+	17	2386	c.2116G>A	c.(2116-2118)Gtg>Atg	p.V706M	COL14A1_ENST00000309791.4_Missense_Mutation_p.V706M|COL14A1_ENST00000247781.3_Missense_Mutation_p.V611M|COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	706	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GAGTGAGGTGGTGACTGCTGT	0.517000													27	185					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51890056	51890056	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:51890056C>A	ENST00000371117.3	-	32	4827	c.4552G>T	c.(4552-4554)Gta>Tta	p.V1518L	PKHD1_ENST00000340994.4_Missense_Mutation_p.V1518L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1518	IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TCCACAAATACCATCGGCTCA	0.502000													41	58					6.2361e-21	9.99681e-21	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8521487	8521487	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:8521487C>A	ENST00000381196.4	-	17	1294	c.751G>T	c.(751-753)Gga>Tga	p.G251*	PTPRD_ENST00000358503.5_Nonsense_Mutation_p.G238*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.G248*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.G241*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.G251*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.G248*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.G251*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.G241*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.G251*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.G251*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.G238*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	251	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTAACGCTTCCGCCTGGCATG	0.468000										TSP Lung(15;0.13)			25	68					1.50538e-07	1.7911e-07	1	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204412697	204412697	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:204412697G>A	ENST00000367187.3	-	20	3452	c.2896C>T	c.(2896-2898)Cag>Tag	p.Q966*	PIK3C2B_ENST00000424712.2_Nonsense_Mutation_p.Q938*	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	966					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			ATGCTGAACTGAGAGTCCTTG	0.567000													64	152					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110295756	110295756	+	Missense_Mutation	SNP	G	G	A	rs77987176		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:110295756G>A	ENST00000369805.3	-	13	1415	c.1186C>T	c.(1186-1188)Cca>Tca	p.P396S	RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Missense_Mutation_p.P395S|EPS8L3_ENST00000361965.4_Missense_Mutation_p.P395S	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	395						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GAGGGCTCTGGAAGTTGCCAG	0.572000													11	44					0	0	1	0	0
DRAP1	10589	broad.mit.edu	37	11	65687863	65687863	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:65687863G>T	ENST00000312515.2	+	4	504	c.259G>T	c.(259-261)Gtg>Ttg	p.V87L	DRAP1_ENST00000527119.1_Missense_Mutation_p.V43L|DRAP1_ENST00000532933.1_Missense_Mutation_p.V67L|DRAP1_ENST00000376991.2_Missense_Mutation_p.V87L	NM_006442.3	NP_006433.2	Q14919	NC2A_HUMAN	DR1-associated protein 1 (negative cofactor 2 alpha)	87					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(1)	5				READ - Rectum adenocarcinoma(159;0.166)		GAAGGACCTGGTGGCATCTGT	0.622000													23	104					1.50039e-11	1.9879e-11	1	1	0
KRT27	342574	broad.mit.edu	37	17	38937465	38937465	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:38937465G>C	ENST00000301656.3	-	2	542	c.502C>G	c.(502-504)Cta>Gta	p.L168V		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	168	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				TCAGCTGTTAGTCTTGCATTA	0.313000													4	15					0	0	1	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46055224	46055224	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:46055224G>C	ENST00000536708.2	+	10	1120	c.1011G>C	c.(1009-1011)tgG>tgC	p.W337C	CDK5RAP3_ENST00000338399.4_Missense_Mutation_p.W312C	NM_001278197.1	NP_001265126.1	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	312					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding			NS(1)|central_nervous_system(2)|cervix(3)|endometrium(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	18						GGATAGACTGGGGAGACGATG	0.547000													9	48					0	0	1	0	0
CDX2	1045	broad.mit.edu	37	13	28537263	28537263	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:28537263C>A	ENST00000381020.7	-	3	3063	c.931G>T	c.(931-933)Gtc>Ttc	p.V311F	CDX2_ENST00000548877.1_5'UTR	NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	311					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CACTGGGTGACGGTGGGGTTT	0.642000			T	ETV6	AML								23	18					3.62473e-10	4.60632e-10	1	1	0
C1orf177	163747	broad.mit.edu	37	1	55277779	55277779	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:55277779C>T	ENST00000358193.3	+	6	733	c.679C>T	c.(679-681)Cga>Tga	p.R227*	C1orf177_ENST00000371273.3_Nonsense_Mutation_p.R227*	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	227										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						ATATGTGGCACGATCCGTCGG	0.587000													5	109					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51875189	51875189	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:51875189G>T	ENST00000371117.3	-	35	5944	c.5669C>A	c.(5668-5670)gCa>gAa	p.A1890E	PKHD1_ENST00000340994.4_Missense_Mutation_p.A1890E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1890					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTCCATCTCTGCCTCAGTTTC	0.443000													17	85					1.15088e-07	1.37516e-07	1	1	0
RHBDF2	79651	broad.mit.edu	37	17	74469808	74469808	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:74469808G>T	ENST00000591885.1	-	15	2205	c.1655C>A	c.(1654-1656)gCc>gAc	p.A552D	RHBDF2_ENST00000389760.4_Missense_Mutation_p.A552D|RHBDF2_ENST00000313080.4_Missense_Mutation_p.A581D			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	581					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						GTTGCTCCTGGCCTGCTCTGT	0.682000													6	17					5.18039e-06	5.89638e-06	1	1	0
OR8K3	219473	broad.mit.edu	37	11	56086338	56086338	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56086338C>A	ENST00000312711.1	+	1	556	c.556C>A	c.(556-558)Cct>Act	p.P186T		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CCCTTTGTTACCTTTGCTTTG	0.328000													16	96					9.16793e-09	1.12097e-08	1	1	0
ZNF280A	129025	broad.mit.edu	37	22	22868752	22868752	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:22868752G>T	ENST00000302097.3	-	2	1455	c.1203C>A	c.(1201-1203)taC>taA	p.Y401*		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CCGACGATCTGTAATGGCAAA	0.413000													37	166					9.62906e-15	1.37558e-14	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91132933	91132933	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:91132933A>T	ENST00000373094.1	+	2	2539	c.1694A>T	c.(1693-1695)gAc>gTc	p.D565V	PCDH11X_ENST00000395337.2_Missense_Mutation_p.D565V|PCDH11X_ENST00000504220.1_Missense_Mutation_p.D565V|PCDH11X_ENST00000361724.1_Missense_Mutation_p.D565V|PCDH11X_ENST00000406881.1_Missense_Mutation_p.D565V|PCDH11X_ENST00000373088.1_Missense_Mutation_p.D565V|PCDH11X_ENST00000298274.8_Missense_Mutation_p.D565V|PCDH11X_ENST00000373097.1_Missense_Mutation_p.D565V|PCDH11X_ENST00000361655.2_Missense_Mutation_p.D565V	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	565	Cadherin 5.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GATCAGAATGACAATAGCCCA	0.383000													70	54					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318174	30318174	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:30318174G>C	ENST00000375377.1	-	3	1004	c.903C>G	c.(901-903)caC>caG	p.H301Q		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	301	Pro-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TAGACTGCTGGTGCGAGCTGT	0.592000													32	142					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93510663	93510663	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:93510663A>T	ENST00000394196.4	+	17	3177	c.2109A>T	c.(2107-2109)aaA>aaT	p.K703N	CHD2_ENST00000557381.1_Missense_Mutation_p.K703N	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	703					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAGTCAAAAAAGATGTGGAGA	0.438000													28	89					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112357060	112357060	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:112357060T>A	ENST00000206423.3	-	2	2646	c.1693A>T	c.(1693-1695)Agt>Tgt	p.S565C	CCDC80_ENST00000439685.2_Missense_Mutation_p.S565C	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	565	Lys-rich.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						tgcttttcactcttaagtaac	0.358000													27	53					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72674378	72674378	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:72674378G>T	ENST00000373514.2	+	3	812	c.812G>T	c.(811-813)gGa>gTa	p.G271V		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	271						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					GCTGTTCGTGGATTTCAACCT	0.428000													22	22					7.33628e-21	1.1738e-20	1	1	0
SCNN1B	6338	broad.mit.edu	37	16	23360114	23360114	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:23360114G>T	ENST00000343070.2	+	2	370	c.194G>T	c.(193-195)tGg>tTg	p.W65L	SCNN1B_ENST00000307331.5_Missense_Mutation_p.W110L|SCNN1B_ENST00000568923.1_Missense_Mutation_p.W65L|SCNN1B_ENST00000568085.1_Missense_Mutation_p.W65L|SCNN1B_ENST00000569789.1_3'UTR	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	65					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CTCGTCTGCTGGCAGTGGGGC	0.602000													20	40					7.21436e-19	1.12641e-18	1	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29891309	29891309	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:29891309T>A	ENST00000308713.5	-	9	1976	c.1449A>T	c.(1447-1449)ccA>ccT	p.P483P	SEZ6L2_ENST00000537485.1_Silent_p.P439P|SEZ6L2_ENST00000350527.3_Silent_p.P413P|SEZ6L2_ENST00000346932.5_Silent_p.P369P	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	483	Sushi 2.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCAGTGCCCCTGGGCGATACT	0.597000													72	93					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131128984	131128984	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:131128984C>T	ENST00000357668.1	-	21	2031	c.2004G>A	c.(2002-2004)caG>caA	p.Q668Q	ASAP1_ENST00000518721.1_Silent_p.Q668Q			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	668					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						TTTCTCCAGCCTGGTTAACTG	0.368000													16	228					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789067	89789067	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:89789067G>T	ENST00000289816.5	+	2	421	c.109G>T	c.(109-111)Gtg>Ttg	p.V37L	ZNF276_ENST00000446326.2_5'UTR|ZNF276_ENST00000443381.2_Missense_Mutation_p.V112L|ZNF276_ENST00000568064.1_Missense_Mutation_p.V37L	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		AGAGGAGCGCGTGCTCGTACG	0.642000													15	79					4.14922e-12	5.58548e-12	1	1	0
GABRG3	2567	broad.mit.edu	37	15	27571991	27571991	+	Nonsense_Mutation	SNP	G	G	A	rs75880610		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:27571991G>A	ENST00000333743.6	+	4	560	c.306G>A	c.(304-306)tgG>tgA	p.W102*	GABRG3_ENST00000555083.1_Nonsense_Mutation_p.W102*	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	102					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CTCAGACCTGGACAGATAGTC	0.398000													74	66					0	0	1	0	0
FAM155B	27112	broad.mit.edu	37	X	68749624	68749624	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:68749624C>T	ENST00000252338.4	+	3	1286	c.1244C>T	c.(1243-1245)cCc>cTc	p.P415L		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	416						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						AGCAACAAGCCCGCCCTGCTG	0.607000													17	34					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76496119	76496119	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:76496119C>A	ENST00000388942.3	+	11	1335	c.1059C>A	c.(1057-1059)acC>acA	p.T353T		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	353						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						GTATGGTCACCACGGCCGCAA	0.597000													35	131					7.63091e-17	1.15287e-16	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141283850	141283850	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:141283850T>A	ENST00000389484.3	-	48	8803	c.7832A>T	c.(7831-7833)aAc>aTc	p.N2611I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2611	LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATGTTCTGGTTGCATCGTGC	0.418000										TSP Lung(27;0.18)			27	28					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197427824	197427824	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:197427824C>A	ENST00000273582.5	-	7	1286	c.741G>T	c.(739-741)tgG>tgT	p.W247C	KIAA0226_ENST00000389665.5_Missense_Mutation_p.W307C|KIAA0226_ENST00000449205.1_Missense_Mutation_p.W307C|KIAA0226_ENST00000296343.5_Missense_Mutation_p.W307C	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	307	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GGCTGCTGACCCAGGATGCCT	0.587000													59	74					9.53978e-28	1.70862e-27	1	1	0
TENM2	57451	broad.mit.edu	37	5	167553868	167553868	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:167553868C>T	ENST00000519204.1	+	11	2074	c.1956C>T	c.(1954-1956)cgC>cgT	p.R652R	TENM2_ENST00000545108.1_Silent_p.R773R|TENM2_ENST00000520394.1_Silent_p.R541R|TENM2_ENST00000403607.2_Silent_p.R606R|TENM2_ENST00000518659.1_Silent_p.R773R|CTB-178M22.1_ENST00000517408.1_RNA					teneurin transmembrane protein 2																		GCCACCCCCGCTGCATTGAGC	0.612000													3	13					0	0	1	0	0
CEP170P1	645455	broad.mit.edu	37	4	119444510	119444510	+	RNA	SNP	C	C	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:119444510C>G	ENST00000412784.2	+	0	83					NR_003135.2																						GCTGGATCAGCAATGCCTACT	0.458000													4	12					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52052535	52052535	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:52052535G>T	ENST00000340057.1	+	2	207	c.162G>T	c.(160-162)cgG>cgT	p.R54R		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	54					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity			endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					TCCATAACCGGAATACCAATA	0.453000													31	161					1.75199e-13	2.44463e-13	1	1	0
DST	667	broad.mit.edu	37	6	56471396	56471396	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:56471396C>A	ENST00000370754.5	-	39	7930	c.7931G>T	c.(7930-7932)gGt>gTt	p.G2644V	DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.G2140V|DST_ENST00000361203.3_Missense_Mutation_p.G2466V|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.G2466V|DST_ENST00000312431.6_Missense_Mutation_p.G2466V|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	2466					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACTTAAGCTACCAACTGGTGC	0.388000													55	68					3.07002e-29	5.55779e-29	1	1	0
SLMO1	10650	broad.mit.edu	37	18	12427071	12427071	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr18:12427071A>T	ENST00000592149.1	+	3	683	c.260A>T	c.(259-261)gAg>gTg	p.E87V	SLMO1_ENST00000590956.1_Missense_Mutation_p.E18V|SLMO1_ENST00000587735.1_Missense_Mutation_p.E18V|SLMO1_ENST00000440960.1_Missense_Mutation_p.E108V|SLMO1_ENST00000336990.4_Missense_Mutation_p.E108V			Q96N28	SLMO1_HUMAN	slowmo homolog 1 (Drosophila)	108	PRELI/MSF1.									endometrium(1)	1						TCAGTTAATGAGAGGTTGGTG	0.438000													32	51					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166794876	166794876	+	Translation_Start_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:166794876C>A	ENST00000061240.2	+	0	467				TLL1_ENST00000507499.1_De_novo_Start_InFrame	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ACAGGCAGTGCTTGCCCTCTC	0.687000													3	2					0.004672	0.00486908	1	1	0
TRBC2	28638	broad.mit.edu	37	7	142498876	142498876	+	RNA	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142498876G>C	ENST00000466254.1	+	0	152																											ATGGGAAGGAGGTGCACAGTG	0.632000													15	100					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111146622	111146622	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:111146622C>A	ENST00000485317.1	-	3	1456	c.783G>T	c.(781-783)gtG>gtT	p.V261V	KCNA2_ENST00000525120.1_5'UTR|KCNA2_ENST00000316361.4_Silent_p.V261V|KCNA2_ENST00000440270.1_Silent_p.V261V|KCNA2_ENST00000369770.3_Silent_p.V261V			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	261						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GGATGATGGCCACAATGTCAA	0.532000													22	70					5.26018e-13	7.23167e-13	1	1	0
DIAPH2	1730	broad.mit.edu	37	X	96354699	96354699	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:96354699G>T	ENST00000324765.8	+	20	2601	c.2254G>T	c.(2254-2256)Gtg>Ttg	p.V752L	DIAPH2_ENST00000355827.4_Missense_Mutation_p.V752L|DIAPH2_ENST00000373049.4_Missense_Mutation_p.V752L|DIAPH2_ENST00000373061.3_Missense_Mutation_p.V752L|DIAPH2_ENST00000373054.4_Missense_Mutation_p.V748L			O60879	DIAP2_HUMAN	diaphanous-related formin 2	752	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						TTAGAACCTTGTGAAACATCT	0.313000													14	22					4.3838e-07	5.12868e-07	1	1	0
SMARCC2	6601	broad.mit.edu	37	12	56559102	56559102	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:56559102C>A	ENST00000394023.3	-	27	3337	c.3232_splice	c.e27+1	p.G1078_splice	SMARCC2_ENST00000267064.4_Splice_Site_p.G1047_splice|SMARCC2_ENST00000347471.4_Splice_Site_p.G1078_splice|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Splice_Site_p.G1078_splice	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1047	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TAACACTTACCATGGGGTCCA	0.577000													12	52					3.07112e-06	3.53389e-06	1	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110476589	110476589	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:110476589C>A	ENST00000378402.5	+	49	7632	c.7528C>A	c.(7528-7530)Cat>Aat	p.H2510N		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2510					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAACACACACCATCTTCTGGT	0.378000										HNSCC(38;0.096)			11	70					4.68919e-08	5.69208e-08	1	1	0
MCM2	4171	broad.mit.edu	37	3	127327830	127327830	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:127327830C>A	ENST00000265056.7	+	8	1636	c.1392C>A	c.(1390-1392)atC>atA	p.I464I		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	464					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						TGAAGATGATCACTAGCCTCT	0.552000													55	93					2.76378e-25	4.78676e-25	1	1	0
PDE1C	5137	broad.mit.edu	37	7	32209467	32209467	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:32209467G>T	ENST00000396193.1	-	3	831	c.238C>A	c.(238-240)Cca>Aca	p.P80T		NM_001191058.1	NP_001177987.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	0					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			ATCTCCTCTGGGGGTCGAGGG	0.502000													15	127					4.35082e-09	5.36665e-09	1	1	0
AGA	175	broad.mit.edu	37	4	178358560	178358560	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:178358560A>T	ENST00000264595.2	-	5	748	c.622_splice	c.e5+1	p.I207_splice	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	207					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		GCAAATTACCAATAGTGTCAT	0.363000													11	30					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10782263	10782263	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:10782263C>T	ENST00000075503.3	-	6	982	c.462G>A	c.(460-462)ggG>ggA	p.G154G		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	154	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CCTCATGGAGCCCAGCTGGTT	0.507000										HNSCC(73;0.22)			12	32					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779474	133779474	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:133779474G>A	ENST00000372338.4	-	7	1605	c.1363C>T	c.(1363-1365)Cgg>Tgg	p.R455W	FIBCD1_ENST00000448616.1_Missense_Mutation_p.R455W|FIBCD1_ENST00000253018.4_Intron|FIBCD1_ENST00000372337.2_Missense_Mutation_p.R297W	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	455	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CGGACCGGCCGGATCTTCATC	0.637000													9	27					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21450339	21450339	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:21450339C>A	ENST00000307378.6	-	10	1794	c.1075_splice	c.e10+1	p.M358_splice	SLCO1A2_ENST00000390670.3_Splice_Site_p.M356_splice|SLCO1A2_ENST00000452078.1_Splice_Site_p.M358_splice|SLCO1A2_ENST00000458504.1_Splice_Site_p.M226_splice|SLCO1A2_ENST00000537524.1_Splice_Site_p.M226_splice	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	358					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						CAAACATACCCATTAGAAAGA	0.403000													23	48					1.96895e-08	2.39698e-08	1	1	0
GABRG3	2567	broad.mit.edu	37	15	27571989	27571989	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:27571989T>A	ENST00000333743.6	+	4	558	c.304T>A	c.(304-306)Tgg>Agg	p.W102R	GABRG3_ENST00000555083.1_Missense_Mutation_p.W102R	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	102					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TGCTCAGACCTGGACAGATAG	0.398000													73	65					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75902629	75902629	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:75902629C>A	ENST00000322563.3	-	4	993	c.869G>T	c.(868-870)gGc>gTc	p.G290V	RP11-619A14.2_ENST00000527314.1_RNA	NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	290					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CCCGTGGGAGCCCACCTTCTC	0.577000													49	53					2.13384e-23	3.59203e-23	1	1	0
OR51B5	282763	broad.mit.edu	37	11	5364533	5364533	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:5364533G>T	ENST00000300773.2	-	1	276	c.222C>A	c.(220-222)acC>acA	p.T74T	AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCATTGTGGTCAGGGCCA	0.542000													16	38					1.5739e-10	2.03083e-10	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10470495	10470495	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:10470495G>T	ENST00000382483.3	-	4	1336	c.1113C>A	c.(1111-1113)ggC>ggA	p.G371G		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	371					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCAAGGGTAGCCCTCCCACA	0.692000													37	37					5.73237e-09	7.06039e-09	1	1	0
HAS2	3037	broad.mit.edu	37	8	122626661	122626661	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:122626661G>A	ENST00000303924.4	-	4	1884	c.1347C>T	c.(1345-1347)ccC>ccT	p.P449P		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	449						integral to plasma membrane	hyaluronan synthase activity	p.P449P(2)	HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			ACATCTTGGCGGGAAGTAAAC	0.408000													51	517					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582223	55582223	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:55582223G>T	ENST00000361849.3	-	34	5663	c.5269C>A	c.(5269-5271)Cct>Act	p.P1757T	PCDH15_ENST00000395433.1_Missense_Mutation_p.P1732T|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.P1715T|PCDH15_ENST00000320301.6_Missense_Mutation_p.P1755T|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.P1752T|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.P1686T|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373957.3_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1755					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ggagaaggaggagaaatagga	0.478000										HNSCC(58;0.16)			7	22					5.18039e-06	5.89638e-06	1	1	0
GABRB2	2561	broad.mit.edu	37	5	160757983	160757983	+	Silent	SNP	G	G	A	rs140538607	byFrequency	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:160757983G>A	ENST00000274547.2	-	9	1201	c.984C>T	c.(982-984)taC>taT	p.Y328Y	GABRB2_ENST00000393959.1_Silent_p.Y328Y|GABRB2_ENST00000517901.1_Silent_p.Y265Y|GABRB2_ENST00000517547.1_Silent_p.Y168Y|GABRB2_ENST00000520240.1_Silent_p.Y328Y|GABRB2_ENST00000353437.6_Silent_p.Y328Y	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	328					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAAAGAAGATGTAGTTGACTA	0.493000													22	142					0	0	1	0	0
ARGFX	503582	broad.mit.edu	37	3	121305341	121305341	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:121305341C>A	ENST00000334384.3	+	4	852	c.842C>A	c.(841-843)gCa>gAa	p.A281E		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	281						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		CTATCTCCTGCACAAACCTGG	0.483000													36	102					2.47316e-13	3.42249e-13	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2910053	2910053	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:2910053G>T	ENST00000602557.1	-	51	8149	c.7594C>A	c.(7594-7596)Cag>Aag	p.Q2532K	CSMD1_ENST00000400186.3_Missense_Mutation_p.Q2532K|CSMD1_ENST00000537824.1_Missense_Mutation_p.Q2531K|CSMD1_ENST00000602723.1_Missense_Mutation_p.Q2532K|CSMD1_ENST00000542608.1_Missense_Mutation_p.Q2531K|CSMD1_ENST00000520002.1_Missense_Mutation_p.Q2532K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2532	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTGCTTGCTGGCTGGATTCA	0.512000													5	9					0.000602214	0.000643588	1	1	0
GPR111	222611	broad.mit.edu	37	6	47649821	47649821	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:47649821G>C	ENST00000398742.2	+	5	1371	c.1322G>C	c.(1321-1323)aGt>aCt	p.S441T	GPR111_ENST00000296862.1_Missense_Mutation_p.S509T|GPR111_ENST00000507065.1_Missense_Mutation_p.S441T			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	509	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TCCTTTCTTAGTGGCCCAATA	0.433000													12	68					0	0	1	0	0
ACCSL	390110	broad.mit.edu	37	11	44080172	44080172	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:44080172G>T	ENST00000378832.1	+	13	1603	c.1547G>T	c.(1546-1548)cGt>cTt	p.R516L		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	516							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups	p.R516H(1)		central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						TTGTTATCCCGTGGCAAAACC	0.517000													51	69					2.55665e-31	4.67883e-31	1	1	0
RPRD1B	58490	broad.mit.edu	37	20	36694589	36694589	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:36694589G>A	ENST00000373433.4	+	6	1164	c.762G>A	c.(760-762)ctG>ctA	p.L254L		NM_021215.3	NP_067038.1	Q9NQG5	RPR1B_HUMAN	regulation of nuclear pre-mRNA domain containing 1B	254										endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)	12						GTCGCCAGCTGGCTCGGATGT	0.498000													89	154					0	0	1	0	0
TRBV20-1	28567	broad.mit.edu	37	7	142334656	142334656	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142334656C>A	ENST00000390394.3	+	0	156																											GCAGGGTTATCTGTAAGAGTG	0.542000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	93					3.11337e-16	4.62873e-16	1	1	0
EPS8L3	79574	broad.mit.edu	37	1	110302415	110302415	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:110302415G>T	ENST00000369805.3	-	4	369	c.140C>A	c.(139-141)cCc>cAc	p.P47H	RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Missense_Mutation_p.P47H|EPS8L3_ENST00000361965.4_Missense_Mutation_p.P47H	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	47						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GGCATCCTCGGGCCCCTGGAC	0.612000													20	43					2.39187e-15	3.47007e-15	1	1	0
F13A1	2162	broad.mit.edu	37	6	6175039	6175039	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:6175039G>T	ENST00000264870.3	-	12	1786	c.1521C>A	c.(1519-1521)ctC>ctA	p.L507L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	507					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTTCTGTGTTGAGGGGCTTTT	0.463000													29	51					2.80507e-11	3.68742e-11	1	1	0
RIF1	55183	broad.mit.edu	37	2	152314448	152314448	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:152314448G>T	ENST00000243326.4	+	23	3309	c.2826G>T	c.(2824-2826)gtG>gtT	p.V942V	RIF1_ENST00000444746.2_Silent_p.V942V|RIF1_ENST00000430328.2_Silent_p.V942V|RIF1_ENST00000453091.2_Silent_p.V942V|RIF1_ENST00000428287.2_Silent_p.V942V			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	942					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTGCCAAAGTGATGATGTTGG	0.328000													54	36					5.82388e-19	9.12698e-19	1	1	0
EPHB1	2047	broad.mit.edu	37	3	134851773	134851773	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:134851773C>T	ENST00000398015.3	+	5	1549	c.1179C>T	c.(1177-1179)atC>atT	p.I393I	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	393	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GCGTCTCCATCAGCAGCCTGT	0.622000													14	40					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71918239	71918239	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:71918239T>A	ENST00000266674.5	+	3	649	c.338T>A	c.(337-339)cTt>cAt	p.L113H	LGR5_ENST00000536515.1_Missense_Mutation_p.L113H|LGR5_ENST00000540815.2_Missense_Mutation_p.L113H			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	113						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTCACTGGCCTTTACAGTCTT	0.418000													19	55					0	0	1	0	0
CDK15	65061	broad.mit.edu	37	2	202698678	202698678	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:202698678C>A	ENST00000450471.2	+	7	800	c.714C>A	c.(712-714)ctC>ctA	p.L238L	CDK15_ENST00000434439.1_Silent_p.L238L|CDK15_ENST00000374598.4_Silent_p.L238L|CDK15_ENST00000488419.1_3'UTR|CDK15_ENST00000410091.3_Silent_p.L187L|CDK15_ENST00000260967.2_Silent_p.L187L	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	238	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	TGGGAGAGCTCAAACTGGCTG	0.517000													54	34					3.28156e-27	5.80317e-27	1	1	0
XIST	7503	broad.mit.edu	37	X	73062534	73062534	+	RNA	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:73062534G>A	ENST00000429829.1	-	0	10054					NR_001564.2																						AAGTAGAGGGGTTCATGTATA	0.443000													11	36					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1159233	1159233	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:1159233C>T	ENST00000263741.7	-	3	734	c.442G>A	c.(442-444)Gcc>Acc	p.A148T	SDF4_ENST00000545427.1_Missense_Mutation_p.A148T|SDF4_ENST00000360001.6_Missense_Mutation_p.A148T	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	148	EF-hand 2.		A -> T (in a colorectal cancer sample; somatic mutation).		cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding	p.A148T(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GGGTCCACGGCGCGGAAGTGT	0.687000													3	14					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820938	35820938	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:35820938G>T	ENST00000399989.1	+	2	904	c.625G>T	c.(625-627)Gtc>Ttc	p.V209F	MAGEB16_ENST00000399985.1_Missense_Mutation_p.V209F|MAGEB16_ENST00000399992.1_Missense_Mutation_p.V241F|MAGEB16_ENST00000399988.1_Missense_Mutation_p.V209F|MAGEB16_ENST00000399987.1_Missense_Mutation_p.V209F	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	209	MAGE.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						CCTGATAATTGTCCTGGGTGT	0.507000													45	38					1.41504e-22	2.33065e-22	1	1	0
ZFP64	55734	broad.mit.edu	37	20	50769804	50769804	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:50769804C>A	ENST00000216923.4	-	6	1276	c.927G>T	c.(925-927)aaG>aaT	p.K309N	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.K307N|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.K255N|ZFP64_ENST00000477786.1_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TCCCGCTGTGCTTGATACGGA	0.582000													17	134					2.48551e-13	3.43392e-13	1	1	0
RIMS1	22999	broad.mit.edu	37	6	73023342	73023342	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:73023342C>T	ENST00000264839.7	+	24	3644	c.3644C>T	c.(3643-3645)tCa>tTa	p.S1215L	RIMS1_ENST00000491071.2_Missense_Mutation_p.S1189L|RIMS1_ENST00000538414.1_Missense_Mutation_p.S172L|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000348717.5_Missense_Mutation_p.S1158L|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000521978.1_Missense_Mutation_p.S1366L|RIMS1_ENST00000517960.1_Missense_Mutation_p.S1158L|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000401910.3_Missense_Mutation_p.S686L|RIMS1_ENST00000520567.1_Intron			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1366					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGCTTTATGTCAGAGCAATCT	0.448000													19	12					0	0	1	0	0
CAT	847	broad.mit.edu	37	11	34473748	34473748	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:34473748C>T	ENST00000241052.4	+	4	563	c.474C>T	c.(472-474)ccC>ccT	p.P158P		NM_001752.3	NP_001743.1	P04040	CATA_HUMAN	catalase	158					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			breast(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(3)	26		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	TCAGGGATCCCATATTGGTAG	0.418000													10	49					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086250	56086250	+	Silent	SNP	T	T	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:56086250T>C	ENST00000312711.1	+	1	468	c.468T>C	c.(466-468)tcT>tcC	p.S156S		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CATTCATTTCTCTTCTAGTCA	0.408000													19	88					0	0	1	0	0
PLSCR2	57047	broad.mit.edu	37	3	146173138	146173138	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:146173138C>A	ENST00000497985.1	-	6	867	c.428G>T	c.(427-429)gGg>gTg	p.G143V	PLSCR2_ENST00000336685.2_Missense_Mutation_p.G70V	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	70					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						TCTAGACCGCCCACAGCAATT	0.403000													73	132					1.79293e-35	3.40738e-35	1	1	0
SLC44A5	204962	broad.mit.edu	37	1	75693544	75693544	+	Splice_Site	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:75693544T>A	ENST00000370855.5	-	13	967		c.e13-2		SLC44A5_ENST00000370859.3_Splice_Site|SLC44A5_ENST00000535611.1_Splice_Site	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5							integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						GCCATATTCCTTGAAAAAGAA	0.343000													10	36					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147381150	147381150	+	Silent	SNP	G	G	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:147381150G>C	ENST00000240986.4	+	2	1121	c.1068G>C	c.(1066-1068)ctG>ctC	p.L356L	GJA8_ENST00000369235.1_Silent_p.L356L	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	356					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CAGAGAGGCTGACCACGGAGG	0.632000													15	11					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25264849	25264849	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr13:25264849G>T	ENST00000218548.6	+	7	1122	c.789G>T	c.(787-789)acG>acT	p.T263T	ATP12A_ENST00000381946.3_Silent_p.T263T	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	263					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATTCCACAACGTGTCTGGAAG	0.552000													46	152					6.4308e-24	1.09129e-23	1	1	0
ATG7	10533	broad.mit.edu	37	3	11348451	11348451	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:11348451A>G	ENST00000354449.3	+	4	275	c.250A>G	c.(250-252)Att>Gtt	p.I84V	ATG7_ENST00000354956.5_Missense_Mutation_p.I84V|ATG7_ENST00000446450.2_Missense_Mutation_p.I84V	NM_006395.2	NP_006386.1	O95352	ATG7_HUMAN	autophagy related 7	84					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	34						CTGCCCAGCTATTGGAACACT	0.498000													95	78					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15818107	15818107	+	Nonstop_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:15818107G>T	ENST00000396355.1	+	10	1833	c.1007G>T	c.(1006-1008)tGa>tTa	p.*336L	MYH11_ENST00000300036.5_Missense_Mutation_p.Q1426K|MYH11_ENST00000452625.2_Missense_Mutation_p.Q1433K|MYH11_ENST00000396324.3_Missense_Mutation_p.Q1433K|MYH11_ENST00000576790.1_Missense_Mutation_p.Q1426K|NDE1_ENST00000396354.1_Nonstop_Mutation_p.*336L|MYH11_ENST00000338282.6_Missense_Mutation_p.Q1426K|NDE1_ENST00000342673.5_Nonstop_Mutation_p.*336L|NDE1_ENST00000571896.1_3'UTR	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	0					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						AGCTCCTGCTGAAGCCTGTTC	0.522000													21	54					2.37509e-13	3.30311e-13	1	1	0
RELN	5649	broad.mit.edu	37	7	103206688	103206688	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:103206688A>G	ENST00000424685.2	-	33	5078	c.4919T>C	c.(4918-4920)aTa>aCa	p.I1640T	RELN_ENST00000428762.1_Missense_Mutation_p.I1640T|RELN_ENST00000343529.5_Missense_Mutation_p.I1640T			P78509	RELN_HUMAN	reelin	1640					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCAGTGAATATCAGAGCAGT	0.348000													7	75					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234862640	234862640	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:234862640C>A	ENST00000324695.4	+	10	1260	c.1220C>A	c.(1219-1221)gCc>gAc	p.A407D	TRPM8_ENST00000433712.2_Missense_Mutation_p.A95D|AC005538.5_ENST00000455991.1_RNA	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	407						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTGAGCAATGCCATCTCCTAC	0.368000													3	26					0.004672	0.00486908	1	1	0
RNF133	168433	broad.mit.edu	37	7	122338115	122338115	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:122338115C>A	ENST00000340112.2	-	1	1095	c.858G>T	c.(856-858)tgG>tgT	p.W286C	CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	286						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GGGGTAAAATCCAGGGGTCAA	0.393000													51	105					2.27781e-18	3.51721e-18	1	1	0
MUC16	94025	broad.mit.edu	37	19	9089551	9089551	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:9089551C>T	ENST00000397910.4	-	1	2467	c.2264G>A	c.(2263-2265)gGg>gAg	p.G755E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	755	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCAGGAGTCCCTGTGGTAAT	0.473000													32	90					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131944587	131944587	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:131944587G>A	ENST00000403834.3	-	5	473	c.300C>T	c.(298-300)tcC>tcT	p.S100S	MED23_ENST00000368053.4_Silent_p.S100S|MED23_ENST00000354577.4_Silent_p.S100S|MED23_ENST00000540546.1_Silent_p.S100S|MED23_ENST00000539158.1_Silent_p.S100S|MED23_ENST00000368068.3_Silent_p.S100S|MED23_ENST00000368060.3_Silent_p.S100S|MED23_ENST00000368058.1_Silent_p.S100S			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	100					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AGTTTATCAGGGATTCACAAA	0.398000													23	71					0	0	1	0	0
DRD3	1814	broad.mit.edu	37	3	113850215	113850215	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:113850215C>A	ENST00000383673.2	-	6	1186	c.756G>T	c.(754-756)ctG>ctT	p.L252L	DRD3_ENST00000467632.1_Silent_p.L252L|DRD3_ENST00000460779.1_Silent_p.L252L|DRD3_ENST00000295881.7_Silent_p.L252L	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	252					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AGTAACGCTTCAGCTCCAGAT	0.507000													46	109					1.76056e-25	3.06184e-25	1	1	0
CEACAM20	125931	broad.mit.edu	37	19	45024562	45024562	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:45024562C>A	ENST00000454753.1	-	0	1254							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CAGTTCCAGACCTCACAGGCA	0.637000													22	24					2.32416e-17	3.54318e-17	1	1	0
MROH2B	133558	broad.mit.edu	37	5	41004914	41004914	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:41004914G>T	ENST00000399564.4	-	36	4423	c.3973C>A	c.(3973-3975)Cga>Aga	p.R1325R	MROH2B_ENST00000506092.2_Silent_p.R880R	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CCGAGCCCTCGGATGGCCATC	0.473000													10	89					6.40141e-05	7.0382e-05	1	1	0
C7orf63	79846	broad.mit.edu	37	7	89906610	89906610	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:89906610G>T	ENST00000389297.4	+	11	1368	c.1117G>T	c.(1117-1119)Gta>Tta	p.V373L	C7orf63_ENST00000316089.8_Missense_Mutation_p.V373L|C7orf63_ENST00000497910.1_Missense_Mutation_p.V355L	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	373							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						ACTATTCAACGTAATTGTGAT	0.284000													25	79					1.42536e-11	1.90047e-11	1	1	0
CAMK2D	817	broad.mit.edu	37	4	114386723	114386723	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:114386723C>T	ENST00000454265.2	-	17	2004	c.1146G>A	c.(1144-1146)ctG>ctA	p.L382L	CAMK2D_ENST00000514328.1_Silent_p.L356L|CAMK2D_ENST00000394526.2_Silent_p.L368L|CAMK2D_ENST00000515496.1_Silent_p.L368L|CAMK2D_ENST00000511664.1_Silent_p.L391L|CAMK2D_ENST00000342666.5_Silent_p.L357L|CAMK2D_ENST00000394524.3_Silent_p.L357L|CAMK2D_ENST00000505990.1_Silent_p.L391L|CAMK2D_ENST00000508738.1_Silent_p.L368L|CAMK2D_ENST00000379773.2_Silent_p.L357L|CAMK2D_ENST00000394522.3_Silent_p.L371L|CAMK2D_ENST00000418639.2_Silent_p.L371L|CAMK2D_ENST00000296402.5_Silent_p.L357L|CAMK2D_ENST00000429180.1_Silent_p.L377L			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	357					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TAGCTTCGATCAGTTGTTCAG	0.338000													22	71					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30734386	30734386	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:30734386G>T	ENST00000262518.4	+	24	4380	c.3995G>T	c.(3994-3996)cGg>cTg	p.R1332L	SRCAP_ENST00000344771.4_Missense_Mutation_p.R1174L|SRCAP_ENST00000395059.2_Missense_Mutation_p.R1270L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1332	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCAGCACCCCGGCCTCCGAGC	0.602000													54	91					2.14674e-31	3.93725e-31	1	1	0
KIF27	55582	broad.mit.edu	37	9	86530332	86530332	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:86530332C>T	ENST00000297814.2	-	2	318	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	KIF27_ENST00000413982.1_Missense_Mutation_p.E59K|KIF27_ENST00000334204.2_Missense_Mutation_p.E59K	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	59	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TTATAAACTTCATCTTGAGTG	0.378000													11	73					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	120053686	120053686	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:120053686C>A	ENST00000313400.4	-	2	649	c.549G>T	c.(547-549)ctG>ctT	p.L183L	ASTN2_ENST00000373996.3_Silent_p.L183L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Silent_p.L183L			O75129	ASTN2_HUMAN	astrotactin 2	183						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TGGCTTGGGCCAGCTGCCCGG	0.602000													77	69					2.08937e-45	4.09108e-45	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113484887	113484887	+	Silent	SNP	T	T	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:113484887T>A	ENST00000297405.5	-	32	5572	c.5328A>T	c.(5326-5328)ccA>ccT	p.P1776P	CSMD3_ENST00000455883.2_Silent_p.P1672P|CSMD3_ENST00000352409.3_Silent_p.P1776P|CSMD3_ENST00000343508.3_Silent_p.P1736P	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1776	CUB 10.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTGGATAGTTTGGTGATAGAA	0.333000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	205					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42568592	42568592	+	Nonsense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr15:42568592A>T	ENST00000318010.8	+	2	316	c.76A>T	c.(76-78)Aag>Tag	p.K26*	GANC_ENST00000440615.2_Nonsense_Mutation_p.K26*|GANC_ENST00000566442.1_Nonsense_Mutation_p.K26*	NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	26					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGACTGTAACAAGATCGCATT	0.294000													6	37					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142499065	142499065	+	RNA	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:142499065C>A	ENST00000466254.1	+	0	341																											AGGATAGGGCCAAACCTGTCA	0.622000													16	124					1.67942e-08	2.04747e-08	1	1	0
MAGI1	9223	broad.mit.edu	37	3	65342344	65342344	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:65342344G>A	ENST00000402939.2	-	23	4097	c.4098C>T	c.(4096-4098)tcC>tcT	p.S1366S	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1395					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCCGGCTGGGGGAGCCGTCTC	0.687000													28	31					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102448264	102448264	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:102448264C>A	ENST00000413150.2	+	7	645	c.590C>A	c.(589-591)cCt>cAt	p.P197H	MAP4K4_ENST00000324219.4_Missense_Mutation_p.P197H|MAP4K4_ENST00000350198.4_Missense_Mutation_p.P197H|MAP4K4_ENST00000350878.4_Missense_Mutation_p.P177H|MAP4K4_ENST00000425019.1_Missense_Mutation_p.P197H|MAP4K4_ENST00000456652.1_Intron|MAP4K4_ENST00000302217.5_Intron|MAP4K4_ENST00000347699.4_Missense_Mutation_p.P197H	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	197	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGGATGGCTCCTGAGGTCATC	0.547000											OREG0014845	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	8					1.08611e-07	1.30519e-07	1	1	0
CACNA1G	8913	broad.mit.edu	37	17	48680525	48680525	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:48680525G>T	ENST00000352832.5	+	20	4437	c.4065G>T	c.(4063-4065)agG>agT	p.R1355S	CACNA1G_ENST00000515411.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000359106.5_Missense_Mutation_p.R1378S|CACNA1G_ENST00000515165.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000510366.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000515765.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000514717.1_Missense_Mutation_p.R1355S|CACNA1G_ENST00000514079.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000513964.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000416767.4_Missense_Mutation_p.R1378S|CACNA1G_ENST00000507336.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000513689.2_Missense_Mutation_p.R1378S|CACNA1G_ENST00000360761.4_Missense_Mutation_p.R1355S|CACNA1G_ENST00000512389.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000503485.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000354983.4_Missense_Mutation_p.R1355S|CACNA1G_ENST00000358244.5_Missense_Mutation_p.R1355S|CACNA1G_ENST00000502264.1_Missense_Mutation_p.R1355S|CACNA1G_ENST00000442258.2_Missense_Mutation_p.R1355S|CACNA1G_ENST00000510115.1_Missense_Mutation_p.R1355S|CACNA1G_ENST00000514181.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000507609.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000507896.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000505165.1_Missense_Mutation_p.R1378S|CACNA1G_ENST00000429973.2_Missense_Mutation_p.R1378S|CACNA1G_ENST00000507510.2_Missense_Mutation_p.R1378S	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1378					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCATGCTGAGGGTGCTGCGGC	0.642000													27	27					7.92952e-12	1.06064e-11	1	1	0
ZHX1	11244	broad.mit.edu	37	8	124265955	124265955	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:124265955C>A	ENST00000395571.3	-	3	2849	c.2232G>T	c.(2230-2232)ggG>ggT	p.G744G	ZHX1_ENST00000522655.1_Silent_p.G744G|ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Silent_p.G744G	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	744	Required for nuclear localization.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GTCTCCCTCTCCCTCTTTTCC	0.478000													69	258					2.81305e-35	5.31003e-35	1	1	0
ZNF622	90441	broad.mit.edu	37	5	16465448	16465448	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr5:16465448C>A	ENST00000308683.2	-	1	453	c.327G>T	c.(325-327)atG>atT	p.M109I		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	109						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TCTTTTCATTCATCATCTCCA	0.557000													20	149					4.35082e-09	5.36665e-09	1	1	0
KRT34	3885	broad.mit.edu	37	17	39538461	39538461	+	Missense_Mutation	SNP	C	C	A	rs139913573		TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:39538461C>A	ENST00000394001.1	-	1	194	c.164G>T	c.(163-165)cGc>cTc	p.R55L		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	55	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity	p.R55H(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				GCAGCTGGTGCGGCAGCCCAG	0.627000													17	120					3.45872e-05	3.85321e-05	1	1	0
SMPD1	6609	broad.mit.edu	37	11	6411875	6411875	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:6411875G>T	ENST00000342245.4	+	1	215	c.47G>T	c.(46-48)gGc>gTc	p.G16V	SMPD1_ENST00000527275.1_Missense_Mutation_p.G16V|SMPD1_ENST00000533196.1_3'UTR|SMPD1_ENST00000356761.2_Missense_Mutation_p.G16V|SMPD1_ENST00000299397.3_Missense_Mutation_p.G16V	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	16					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CCCAGGTCCGGCCGGGAGCAG	0.731000													8	9					5.18039e-06	5.89638e-06	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113317028	113317028	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:113317028G>T	ENST00000297405.5	-	52	8432	c.8188C>A	c.(8188-8190)Cat>Aat	p.H2730N	CSMD3_ENST00000455883.2_Intron|CSMD3_ENST00000352409.3_Missense_Mutation_p.H2660N|CSMD3_ENST00000343508.3_Missense_Mutation_p.H2690N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2730	Sushi 16.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCTAGTCCATGATAACCAGGG	0.408000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			44	166					3.43241e-23	5.75495e-23	1	1	0
CCHCR1	54535	broad.mit.edu	37	6	31112828	31112828	+	Silent	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:31112828C>A	ENST00000396268.3	-	14	2087	c.1899G>T	c.(1897-1899)ctG>ctT	p.L633L	CCHCR1_ENST00000376266.5_Silent_p.L544L|CCHCR1_ENST00000451521.2_Silent_p.L597L|CCHCR1_ENST00000396263.2_Silent_p.L491L	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	544					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CCACCTTGCTCAGCTGCTGCC	0.662000													22	29					1.96292e-10	2.51734e-10	1	1	0
CARD9	64170	broad.mit.edu	37	9	139265007	139265007	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:139265007C>A	ENST00000371732.5	-	5	939	c.774G>T	c.(772-774)caG>caT	p.Q258H	CARD9_ENST00000371734.3_Missense_Mutation_p.Q258H|CARD9_ENST00000315908.7_Missense_Mutation_p.Q258H	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	258					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GCACCCGGGCCTGGAGCAGGG	0.706000													3	15					0.004672	0.00486908	1	1	0
SLC24A2	25769	broad.mit.edu	37	9	19785954	19785954	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:19785954G>T	ENST00000341998.2	-	1	972	c.911C>A	c.(910-912)gCa>gAa	p.A304E	SLC24A2_ENST00000286344.3_Missense_Mutation_p.A304E	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	304					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCTTCTGGTGCTGTCACCTT	0.378000													31	107					9.17885e-22	1.48846e-21	1	1	0
ANO7	50636	broad.mit.edu	37	2	242140752	242140752	+	Silent	SNP	C	C	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:242140752C>T	ENST00000274979.8	+	7	859	c.756C>T	c.(754-756)agC>agT	p.S252S	ANO7_ENST00000402430.3_Silent_p.S251S	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	252						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						TCTTCACAAGCACCAAGAGGC	0.597000													15	19					0	0	1	0	0
SCPEP1	59342	broad.mit.edu	37	17	55083532	55083532	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:55083532A>T	ENST00000262288.3	+	13	1351		c.e13-1			NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1						proteolysis	extracellular region	serine-type carboxypeptidase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					GTTTTTTTCTAGGTTCCTTCT	0.517000													47	67					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152285986	152285986	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:152285986C>A	ENST00000368799.1	-	3	1411	c.1376G>T	c.(1375-1377)gGg>gTg	p.G459V	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	459	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCGTTCCCCTGACCGGCC	0.587000									Ichthyosis				218	305					1.75383e-81	3.5585e-81	1	1	0
GPR78	27201	broad.mit.edu	37	4	8582790	8582790	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:8582790G>T	ENST00000382487.4	+	1	498	c.81G>T	c.(79-81)ctG>ctT	p.L27L	GPR78_ENST00000509216.1_Intron	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	27					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						CACTGGTGCTGCTTTGTTGCG	0.682000											OREG0005236	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=GPR78|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	5	18					8.12818e-05	8.8902e-05	1	1	0
FTCD	10841	broad.mit.edu	37	21	47556894	47556894	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:47556894C>A	ENST00000397748.1	-	14	1656	c.1613G>T	c.(1612-1614)cGg>cTg	p.R538L	FTCD_ENST00000291670.5_Intron|FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000359679.2_Missense_Mutation_p.R538L|FTCD_ENST00000397743.1_3'UTR|FTCD_ENST00000397746.3_3'UTR|FTCD_ENST00000355384.2_Intron			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	45	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	AGAGGCCTCCCGCACCGTCAC	0.667000													4	30					0.184627	0.186179	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168100032	168100032	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr2:168100032G>T	ENST00000409195.1	+	9	2219	c.2130G>T	c.(2128-2130)gtG>gtT	p.V710V	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.V488V|XIRP2_ENST00000295237.9_Silent_p.V710V	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	535					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTCATTCAGTGGATGAGGTTC	0.373000													64	38					4.80186e-42	9.33695e-42	1	1	0
HOXA7	3204	broad.mit.edu	37	7	27194648	27194648	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:27194648G>A	ENST00000242159.3	-	2	706	c.573C>T	c.(571-573)gaC>gaT	p.D191D	HOXA7_ENST00000523796.2_5'UTR|HOXA-AS3_ENST00000518947.2_RNA	NM_006896.3	NP_008827.2	P31268	HXA7_HUMAN	homeobox A7	191					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding			endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|urinary_tract(1)	16						TCGGACCTTCGTCCTTATGCT	0.642000													31	139					0	0	1	0	0
ABT1	29777	broad.mit.edu	37	6	26598247	26598247	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:26598247G>T	ENST00000274849.1	+	2	378	c.347G>T	c.(346-348)cGc>cTc	p.R116L		NM_013375.3	NP_037507.1	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	116	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11						CGTGACAAGCGCATAGCCAAG	0.582000													11	56					6.40141e-05	7.0382e-05	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113702182	113702182	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:113702182G>T	ENST00000297405.5	-	14	2314	c.2070C>A	c.(2068-2070)tgC>tgA	p.C690*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.C586*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.C690*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.C650*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	690	Sushi 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACCCAAACTGGCATTCAAACC	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	427					4.0306e-16	5.96074e-16	1	1	0
LRP4	4038	broad.mit.edu	37	11	46916282	46916282	+	Silent	SNP	G	G	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:46916282G>A	ENST00000378623.1	-	12	1640	c.1398C>T	c.(1396-1398)aaC>aaT	p.N466N		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	466					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATTCTCCAGGTTGTTAAGCA	0.587000													5	55					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84349180	84349180	+	Silent	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:84349180G>T	ENST00000509231.1	-	4	1909	c.1830C>A	c.(1828-1830)ggC>ggA	p.G610G	SATL1_ENST00000332921.5_Silent_p.G423G|SATL1_ENST00000395409.3_Silent_p.G423G			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	423							N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						AAAGTACCTTGCCAGTCCATG	0.348000													41	43					1.61863e-15	2.35641e-15	1	1	0
ENAM	10117	broad.mit.edu	37	4	71508513	71508513	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr4:71508513C>A	ENST00000396073.3	+	9	1651	c.1370C>A	c.(1369-1371)cCc>cAc	p.P457H	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	457					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CCAACCAGCCCCTGGAGAAAC	0.393000													12	26					0.000978159	0.00103875	1	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12884856	12884856	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:12884856G>T	ENST00000535591.1	-	4	1450	c.1255C>A	c.(1255-1257)Cct>Act	p.P419T		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	419										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						CCATGGTCAGGGCAGTTGTCA	0.478000													47	228					2.13384e-23	3.59203e-23	1	1	0
PCDH15	65217	broad.mit.edu	37	10	55566771	55566771	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr10:55566771A>T	ENST00000373965.2	-	36	5017	c.4623T>A	c.(4621-4623)agT>agA	p.S1541R	PCDH15_ENST00000414778.1_Missense_Mutation_p.S1538R	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CGTTGATATTACTGTGGATAC	0.458000										HNSCC(58;0.16)			32	27					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118583386	118583387	+	Frame_Shift_Ins	INS	-	-	C			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:118583386_118583387insC	ENST00000336338.5	-	22	3197_3198	c.3132_3133insG	c.(3130-3135)ggagatfs	p.D1045fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1045						cilium|flagellar axoneme|microtubule		p.Q1045K(1)		NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACTTCAATCTGCCCCCCATCAG	0.371													15	74	---	---	---	---					
OR6Y1	391112	broad.mit.edu	37	1	158517642	158517642	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:158517642delT	ENST00000302617.3	-	1	253	c.254delA	c.(253-255)agfs	p.K85fs		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					AACAAGCATCTTGGGGCTGAT	0.458													19	155	---	---	---	---					
CR1	1378	broad.mit.edu	37	1	207684993	207684994	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr1:207684993_207684994delTG	ENST00000367049.4	+	4	481_482	c.481_482delTG	c.(481-483)tfs	p.C161fs	CR1_ENST00000367050.4_3'UTR|CR1_ENST00000400960.2_Frame_Shift_Del_p.C161fs|CR1_ENST00000367053.1_Frame_Shift_Del_p.C161fs|CR1_ENST00000367052.1_Frame_Shift_Del_p.C161fs|CR1_ENST00000367051.1_Frame_Shift_Del_p.C161fs	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	161	Sushi 2.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AACACCTATTTGTGACAGtgag	0.366													38	61	---	---	---	---					
DNAJB8	165721	broad.mit.edu	37	3	128181859	128181860	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr3:128181859_128181860insA	ENST00000469083.1	-	2	2786_2787	c.229_230insT	c.(229-231)cggfs	p.R77fs	DNAJB8_ENST00000319153.3_Frame_Shift_Ins_p.R77fs			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	77					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		GCTGGCCCCGCCACCAGCCCGC	0.594													54	133	---	---	---	---					
ZNF311	282890	broad.mit.edu	37	6	28964137	28964137	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:28964137delG	ENST00000377179.3	-	7	1154	c.642delC	c.(640-642)acfs	p.T214fs	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						CTTTTTTGCAGGTCACTTCCT	0.358													26	163	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43310508	43310509	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:43310508_43310509insA	ENST00000361428.2	-	7	3258_3259	c.3181_3182insT	c.(3181-3183)tgafs	p.*1061fs	ZNF318_ENST00000318149.3_Frame_Shift_Ins_p.*1061fs	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1061					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCCAGCATCATAATACTCATAA	0.470													29	122	---	---	---	---					
COL10A1	1300	broad.mit.edu	37	6	116442406	116442406	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr6:116442406delC	ENST00000327673.4	-	2	1280	c.873delG	c.(871-873)ggfs	p.G291fs	AL121963.1_ENST00000430695.1_Frame_Shift_Del_p.G20fs|NT5DC1_ENST00000319550.4_Intron|COL10A1_ENST00000243222.4_Frame_Shift_Del_p.G291fs			Q03692	COAA1_HUMAN	collagen, type X, alpha 1	291	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)|endometrium(2)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	13		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GCCCTGGGGGCCCAGCTATTC	0.637													30	37	---	---	---	---					
ADCY1	107	broad.mit.edu	37	7	45725604	45725604	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:45725604delC	ENST00000297323.7	+	13	2139	c.2117delC	c.(2116-2118)tcfs	p.S706fs		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	706					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	CCCAACAGTTCCCTGGTGGTC	0.672													22	38	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82580168	82580168	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:82580168delG	ENST00000423517.2	-	6	10073	c.9736delC	c.(9736-9738)gafs	p.R3246fs	PCLO_ENST00000333891.8_Frame_Shift_Del_p.R3246fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3177	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.R3246R(2)|p.R3177R(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGTTCTCGGAACCTTTGA	0.473													32	104	---	---	---	---					
ABCB1	5243	broad.mit.edu	37	7	87178756	87178756	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr7:87178756delG	ENST00000265724.3	-	15	2050	c.1633delC	c.(1633-1635)tgfs	p.L545fs	ABCB1_ENST00000543898.1_Frame_Shift_Del_p.L481fs	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	545	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTGCGAACCAGGGCACGTGCA	0.557													30	69	---	---	---	---					
SLCO5A1	81796	broad.mit.edu	37	8	70594565	70594565	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr8:70594565delT	ENST00000260126.3	-	7	2342	c.1636delA	c.(1636-1638)tgfs	p.M546fs	SLCO5A1_ENST00000524945.1_Frame_Shift_Del_p.M546fs|SLCO5A1_ENST00000530307.1_Frame_Shift_Del_p.M491fs	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	546						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CTATGGGGCATGGTGAGAGAA	0.378													27	310	---	---	---	---					
TOPORS	10210	broad.mit.edu	37	9	32550857	32550857	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:32550857delC	ENST00000360538.2	-	2	229	c.113delG	c.(112-114)gafs	p.G38fs	TOPORS_ENST00000379858.1_Intron	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	38	E3 ubiquitin-protein ligase activity.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TCGGCAGGATCCGCGAAGGCG	0.721													11	44	---	---	---	---					
RNF183	138065	broad.mit.edu	37	9	116059733	116059733	+	Splice_Site	DEL	A	A	-	rs3750535	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr9:116059733delA	ENST00000478815.1	-	1	2312		c.e1+1		RNF183_ENST00000297894.5_Intron|RNF183_ENST00000416588.2_3'UTR|RNF183_ENST00000441031.3_3'UTR			Q96D59	RN183_HUMAN	ring finger protein 183							integral to membrane	zinc ion binding			lung(1)|prostate(1)|skin(1)	3						GTTTTTTTTTAAAATTGTTCC	0.443													2	4	---	---	---	---					
USH1C	10083	broad.mit.edu	37	11	17527486	17527486	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:17527486delG	ENST00000005226.7	-	19	2023	c.2024delC	c.(2023-2025)cafs	p.P675fs	USH1C_ENST00000318024.4_Intron|USH1C_ENST00000529563.1_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000527020.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CTGTGGGCTTGGGCAAAATGT	0.537													9	40	---	---	---	---					
OR5L2	26338	broad.mit.edu	37	11	55595033	55595033	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:55595033delC	ENST00000378397.1	+	1	339	c.339delC	c.(337-339)ttfs	p.F113fs		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CTGAGGTCTTCCTGCTGGCCG	0.502										HNSCC(27;0.073)			97	192	---	---	---	---					
ATG2A	23130	broad.mit.edu	37	11	64662492	64662492	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:64662492delG	ENST00000421419.2	-	41	5890	c.5776delC	c.(5776-5778)acfs	p.H1926fs	ATG2A_ENST00000377264.3_Frame_Shift_Del_p.H1924fs			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1924							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TGGTCCTTGTGGGCGTCGGGG	0.697													20	92	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													8	20	---	---	---	---					
CD163	9332	broad.mit.edu	37	12	7639537	7639537	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:7639537delC	ENST00000359156.4	-	9	2298	c.2096delG	c.(2095-2097)gcfs	p.G699fs	CD163_ENST00000432237.2_Frame_Shift_Del_p.G699fs|CD163_ENST00000396620.3_Frame_Shift_Del_p.G732fs|CD163_ENST00000541972.1_Frame_Shift_Del_p.G687fs	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	699					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CCTTGTTGGGCCCAAAGACGA	0.443													19	77	---	---	---	---					
LOC101927058	101927058	broad.mit.edu	37	12	43018865	43018867	+	RNA	DEL	TTC	TTC	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr12:43018865_43018867delTTC	ENST00000550337.1	-	0	752																											ctcttcttctttcttcttcttct	0.453													2	4	---	---	---	---					
CORO1A	11151	broad.mit.edu	37	16	30198403	30198403	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr16:30198403delG	ENST00000219150.5	+	5	800	c.495delG	c.(493-495)gcfs	p.A166fs	CORO1A_ENST00000565497.1_Frame_Shift_Del_p.A166fs|CORO1A_ENST00000570045.1_Frame_Shift_Del_p.A166fs	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	166					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						GCACTGGGGCGGCCATGCTGA	0.607													14	72	---	---	---	---					
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3594303	3594304	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:3594303_3594304insA	ENST00000550383.1	-	3	494_495	c.306_307insT	c.(304-309)tttggtfs	p.G103fs	P2RX5_ENST00000552276.1_Frame_Shift_Ins_p.G103fs|P2RX5_ENST00000552050.1_Intron|P2RX5_ENST00000551178.1_Intron|P2RX5_ENST00000345901.3_Intron|P2RX5_ENST00000547178.1_Frame_Shift_Ins_p.G103fs|P2RX5_ENST00000435558.1_Frame_Shift_Ins_p.G103fs|P2RX5_ENST00000225328.5_Frame_Shift_Ins_p.G103fs																							TTGGTGACCACAAAAAAGACGT	0.599													14	22	---	---	---	---					
KIAA0100	9703	broad.mit.edu	37	17	26946973	26946973	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr17:26946973delC	ENST00000528896.2	-	30	5499	c.5425delG	c.(5425-5427)agfs	p.E1809fs	KIAA0100_ENST00000544884.1_Frame_Shift_Del_p.E1666fs|KIAA0100_ENST00000389003.3_Frame_Shift_Del_p.E1666fs	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1809						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CTGCGTTGCTCCTCTGGATTG	0.458													53	66	---	---	---	---					
MYH14	79784	broad.mit.edu	37	19	50766585	50766587	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr19:50766585_50766587delCAG	ENST00000440075.2	+	22	2649_2651	c.2602_2604delCAG	c.(2602-2604)del	p.Q871del	MYH14_ENST00000376970.2_In_Frame_Del_p.Q863del|MYH14_ENST00000601313.1_In_Frame_Del_p.Q871del|MYH14_ENST00000598205.1_In_Frame_Del_p.Q838del|MYH14_ENST00000596571.1_In_Frame_Del_p.Q830del|MYH14_ENST00000262269.8_In_Frame_Del_p.Q871del|MYH14_ENST00000425460.1_In_Frame_Del_p.Q838del			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	830					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCAGAAGCGCCAGCAGCAGCAGA	0.621													2	4	---	---	---	---					
ZFP64	55734	broad.mit.edu	37	20	50769422	50769422	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:50769422delC	ENST00000216923.4	-	6	1658	c.1309delG	c.(1309-1311)agfs	p.E437fs	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Frame_Shift_Del_p.E435fs|ZFP64_ENST00000346617.4_Frame_Shift_Del_p.E383fs|ZFP64_ENST00000477786.1_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						AGCGAGTCCTCCCGCATGAAG	0.572													15	130	---	---	---	---					
DIDO1	11083	broad.mit.edu	37	20	61528088	61528088	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr20:61528088delC	ENST00000266070.4	-	7	2174	c.1849delG	c.(1849-1851)cafs	p.A617fs	DIDO1_ENST00000395343.1_Frame_Shift_Del_p.A617fs|DIDO1_ENST00000395340.1_Frame_Shift_Del_p.A617fs|DIDO1_ENST00000395335.2_Frame_Shift_Del_p.A617fs	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	617					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCTGCAGGTGCCGGTCCGGCC	0.617													42	180	---	---	---	---					
KCNJ15	3772	broad.mit.edu	37	21	39671519	39671520	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr21:39671519_39671520delCT	ENST00000398930.1	+	4	690_691	c.336_337delCT	c.(334-339)gactfs	p.DS112fs	KCNJ15_ENST00000328656.3_Frame_Shift_Del_p.DS112fs|KCNJ15_ENST00000398934.1_Frame_Shift_Del_p.DS112fs|KCNJ15_ENST00000398938.2_Frame_Shift_Del_p.DS112fs|KCNJ15_ENST00000398932.1_Frame_Shift_Del_p.DS112fs			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	112					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TGAAAGTGGACTCTCTCACTGG	0.485													56	83	---	---	---	---					
CES5AP1	649264	broad.mit.edu	37	22	23722754	23722754	+	RNA	DEL	C	C	-			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chr22:23722754delC	ENST00000415114.1	-	0	353																											ccctgcccctcctcccaccct	0.642													2	4	---	---	---	---					
FRMPD4	9758	broad.mit.edu	37	X	12720094	12720095	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A4YF-01A-12D-A25L-08	TCGA-NJ-A4YF-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3052FDBB-2E49-4D68-91B9-993BD2D6D6B1	169D6639-F7F7-4C2C-A72F-0ADD3E667DA6	g.chrX:12720094_12720095insA	ENST00000380682.1	+	10	1541_1542	c.1035_1036insA	c.(1033-1038)acagcafs	p.A346fs		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	346	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCGTTACCACCAAGCAAACGCA	0.505											OREG0019670	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	103	---	---	---	---					
