Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XPNPEP1	7511	broad.mit.edu	37	10	111628386	111628386	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:111628386G>C	ENST00000502935.1	-	20	1977	c.1858C>G	c.(1858-1860)Ctt>Gtt	p.L620V	XPNPEP1_ENST00000322238.8_Missense_Mutation_p.L596V|XPNPEP1_ENST00000369680.4_Missense_Mutation_p.L577V|XPNPEP1_ENST00000369683.1_Missense_Mutation_p.L506V			Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	577					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		TTGTCTGTAAGAGAATCCACA	0.423000													19	372					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191897800	191897800	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:191897800C>T	ENST00000392320.2	-	21	2242	c.1928G>A	c.(1927-1929)cGa>cAa	p.R643Q	STAT4_ENST00000358470.4_Missense_Mutation_p.R643Q	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	643	SH2.				JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TTTGTAGTCTCGCAGGATGTC	0.433000													9	111					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167419951	167419951	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:167419951A>G	ENST00000519204.1	+	4	705	c.587A>G	c.(586-588)cAc>cGc	p.H196R	TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000545108.1_Missense_Mutation_p.H317R|TENM2_ENST00000403607.2_Missense_Mutation_p.H150R|TENM2_ENST00000518659.1_Missense_Mutation_p.H317R|TENM2_ENST00000520394.1_Missense_Mutation_p.H126R					teneurin transmembrane protein 2																		CCTGGCAGGCACTTCCTCTTC	0.537000													8	79					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104933980	104933980	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:104933980G>A	ENST00000507740.1	+	8	1824	c.1588G>A	c.(1588-1590)Gat>Aat	p.D530N	RIMS2_ENST00000262231.10_Missense_Mutation_p.D577N|RIMS2_ENST00000436393.2_Missense_Mutation_p.D500N|RIMS2_ENST00000406091.3_Missense_Mutation_p.D722N	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	800					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AATGTTGAGGGATGTCCCACA	0.358000										HNSCC(12;0.0054)			14	89					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10032131	10032131	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:10032131C>G	ENST00000396573.2	-	4	1001	c.692G>C	c.(691-693)tGt>tCt	p.C231S	GRIN2A_ENST00000404927.2_Missense_Mutation_p.C231S|GRIN2A_ENST00000396575.2_Missense_Mutation_p.C231S|GRIN2A_ENST00000535259.1_Missense_Mutation_p.C74S|GRIN2A_ENST00000330684.3_Missense_Mutation_p.C231S|GRIN2A_ENST00000562109.1_Missense_Mutation_p.C231S|GRIN2A_ENST00000566670.1_5'UTR	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	231					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCTTTGGAACAGTAGAGCAA	0.507000													21	115					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045520	53045520	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:53045520C>T	ENST00000309680.3	-	1	428	c.407G>A	c.(406-408)gGg>gAg	p.G136E		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	136	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		ACCAGGACCCCCTAAacctcc	0.612000													27	51					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27013422	27013422	+	Silent	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:27013422A>T	ENST00000314616.6	+	20	2836	c.2553A>T	c.(2551-2553)gcA>gcT	p.A851A	SUPT6H_ENST00000347486.4_Silent_p.A851A	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	851					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TGACAGTTGCAGGAGAGAACA	0.443000													9	61					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100705969	100705969	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:100705969C>G	ENST00000262238.4	+	1	648	c.388C>G	c.(388-390)Cag>Gag	p.Q130E		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	130					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				CTTCGAGGATCAGATTCTCAT	0.716000													6	73					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551341	248551341	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:248551341C>G	ENST00000355728.2	+	1	432	c.432C>G	c.(430-432)atC>atG	p.I144M		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGGATGATCCTGGCCAGCT	0.552000													32	89					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131793006	131793006	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:131793006C>T	ENST00000286355.5	-	18	5478	c.3386G>A	c.(3385-3387)cGg>cAg	p.R1129Q	ADCY8_ENST00000377928.3_Missense_Mutation_p.R998Q	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1129					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GACTTGGATCCGGCCACTAAC	0.527000										HNSCC(32;0.087)			12	145					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128483892	128483892	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:128483892C>T	ENST00000325888.8	+	19	3115	c.2854C>T	c.(2854-2856)Ccc>Tcc	p.P952S	FLNC_ENST00000346177.6_Missense_Mutation_p.P952S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	952					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GGACCCTGTCCCCAAGAGCCC	0.542000													18	107					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565243	20565243	+	Splice_Site	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:20565243C>G	ENST00000329697.6	-	5	765		c.e5-1		ACSM2B_ENST00000565232.1_Splice_Site|ACSM2B_ENST00000565322.1_Splice_Site|ACSM2B_ENST00000567001.1_Splice_Site	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B						fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						GGATGCCTCACTGACAAAGAC	0.498000													7	127					0	0	1	0	0
OR7G3	390883	broad.mit.edu	37	19	9237522	9237522	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:9237522G>T	ENST00000305444.2	-	1	104	c.105C>A	c.(103-105)taC>taA	p.Y35*		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						TTGTGGCCAGGTACATGGACA	0.542000													14	85					1.49906e-05	1.73026e-05	1	1	0
KRT16	3868	broad.mit.edu	37	17	39768577	39768577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:39768577G>A	ENST00000301653.4	-	1	428	c.364C>T	c.(364-366)Cag>Tag	p.Q122*		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	122	Coil 1A.|Rod.		Q -> P (in PC1; dbSNP:rs59349773).		cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				TTGAGGTTCTGCATGGTCACC	0.602000													32	138					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746311	15746311	+	Missense_Mutation	SNP	C	C	A	rs138597725	byFrequency	TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr21:15746311C>A	ENST00000285667.3	-	5	1110	c.1043G>T	c.(1042-1044)gGc>gTc	p.G348V	HSPA13_ENST00000544452.1_Missense_Mutation_p.G140V	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	348						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATCAGAAAGGCCACGTCCAAA	0.423000													40	121					9.62906e-15	1.2988e-14	1	1	0
ARHGEF12	23365	broad.mit.edu	37	11	120347996	120347996	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:120347996C>T	ENST00000397843.2	+	35	3600	c.3434C>T	c.(3433-3435)cCa>cTa	p.P1145L	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.P1126L|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.P1042L	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1145					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATTCCATTACCACAGTCAACA	0.408000			T	MLL	AML								5	39					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13781935	13781935	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:13781935G>T	ENST00000380567.1	+	20	3012	c.2140G>T	c.(2140-2142)Gct>Tct	p.A714S	OFD1_ENST00000340096.6_Missense_Mutation_p.A854S|OFD1_ENST00000380550.3_Missense_Mutation_p.A814S|OFD1_ENST00000490265.1_3'UTR			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	854	Mediates the interaction with SDCCAG8.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TCATGTGGACGCTGCTGCAGC	0.527000													29	78					2.24059e-21	3.13143e-21	1	1	0
FEM1A	55527	broad.mit.edu	37	19	4793717	4793717	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:4793717C>A	ENST00000269856.3	+	1	1990	c.1851C>A	c.(1849-1851)gcC>gcA	p.A617A	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	617					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity	p.A617A(4)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		AGAAGACGGCCTACGAGCTGC	0.607000													4	34					1	1	1	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140783009	140783009	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:140783009G>A	ENST00000573521.1	+	1	490	c.490G>A	c.(490-492)Gtg>Atg	p.V164M	PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGTTGGCGTGAACTCCCT	0.522000													16	163					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128466446	128466446	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:128466446G>A	ENST00000322313.4	-	21	3744	c.3586C>T	c.(3586-3588)Cgt>Tgt	p.R1196C		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1196					postreplication repair|spermatogenesis	collagen|nucleus	protein binding	p.R1196C(1)		NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGAGTATCACGAAAATGTTCA	0.517000													9	39					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15890626	15890626	+	RNA	SNP	G	G	A	rs55782900	by1000genomes	TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:15890626G>A	ENST00000587443.2	-	0	171					NR_033864.1																						CCAGGAAGCCGGCCAGGAGCC	0.637000													4	37					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136596984	136596984	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:136596984T>C	ENST00000531224.1	-	5	1931	c.1679A>G	c.(1678-1680)aAc>aGc	p.N560S	BCLAF1_ENST00000527536.1_Missense_Mutation_p.N560S|BCLAF1_ENST00000392348.2_Missense_Mutation_p.N558S|BCLAF1_ENST00000527759.1_Missense_Mutation_p.N558S|BCLAF1_ENST00000530767.1_Missense_Mutation_p.N387S|BCLAF1_ENST00000353331.4_Missense_Mutation_p.N558S	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	560					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GAATTACCTGTTAGAATCATC	0.368000													12	202					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89157136	89157136	+	RNA	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:89157136C>T	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							AGAGGCAGTTCCAGATTTCAA	0.488000													7	31					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70784555	70784555	+	Silent	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:70784555T>C	ENST00000373719.3	+	19	2758	c.2541T>C	c.(2539-2541)ttT>ttC	p.F847F	OGT_ENST00000373701.3_Silent_p.F837F	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	847					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					ACTGTAACTTTAATCAGTTGT	0.408000													17	27					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134644745	134644745	+	Silent	SNP	T	T	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:134644745T>A	ENST00000361388.2	+	12	1861	c.1395T>A	c.(1393-1395)ccT>ccA	p.P465P	CALD1_ENST00000466704.1_3'UTR|CALD1_ENST00000417172.1_Silent_p.P439P|CALD1_ENST00000495522.1_Silent_p.P458P|CALD1_ENST00000424922.1_Silent_p.P433P|CALD1_ENST00000361901.2_Silent_p.P439P|CALD1_ENST00000543443.1_Silent_p.P444P|CALD1_ENST00000393118.2_Silent_p.P459P|CALD1_ENST00000361675.2_Silent_p.P694P|CALD1_ENST00000422748.1_Silent_p.P464P	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	694					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GCGCAAAACCTACAAAGCCGG	0.438000													11	44					0	0	1	0	0
TSPAN13	27075	broad.mit.edu	37	7	16793610	16793610	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:16793610C>T	ENST00000262067.4	+	1	451	c.18C>T	c.(16-18)ttC>ttT	p.F6F		NM_014399.3	NP_055214.1	O95857	TSN13_HUMAN	tetraspanin 13	6						integral to plasma membrane|membrane fraction				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	7	Lung NSC(10;0.0494)|all_lung(11;0.109)			UCEC - Uterine corpus endometrioid carcinoma (126;0.188)		GCGGGGGCTTCGCGTGTTCCA	0.592000													3	27					0	0	1	0	0
PIK3R2	5296	broad.mit.edu	37	19	18273875	18273875	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:18273875A>G	ENST00000593731.1	+	10	1768	c.1208A>G	c.(1207-1209)aAt>aGt	p.N403S	PIK3R2_ENST00000222254.7_Missense_Mutation_p.N403S			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	403	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						GACCTCATCAATCACTACCGC	0.562000													9	49					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577092	158577092	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:158577092T>G	ENST00000361284.1	+	1	864	c.864T>G	c.(862-864)atT>atG	p.I288M		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TTAATCCCATTGTTTATAGTC	0.468000													54	360					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9054339	9054339	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:9054339C>T	ENST00000382496.5	-	19	3214	c.2549G>A	c.(2548-2550)tGg>tAg	p.W850*		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	850	TSP type-1 6.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						ACATTTTGTCCAGGGGGACCA	0.527000													7	72					0	0	1	0	0
ORC3	23595	broad.mit.edu	37	6	88318846	88318846	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:88318846G>C	ENST00000392844.3	+	7	660	c.612G>C	c.(610-612)agG>agC	p.R204S	ORC3_ENST00000257789.4_Missense_Mutation_p.R204S|ORC3_ENST00000417380.2_Missense_Mutation_p.R151S|ORC3_ENST00000478028.1_3'UTR|ORC3_ENST00000546266.1_Missense_Mutation_p.R61S	NM_012381.3|NM_181837.2	NP_036513.2|NP_862820.1	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3	204					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	28						GCAAAAAAAGGACTACTTCTA	0.383000													18	82					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907391	164907391	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:164907391C>A	ENST00000475390.1	-	2	1671	c.1228G>T	c.(1228-1230)Gcc>Tcc	p.A410S	SLITRK3_ENST00000241274.3_Missense_Mutation_p.A410S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	410						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						AGTTTCTTGGCATTCAAGGGC	0.398000										HNSCC(40;0.11)			21	121					3.62473e-10	4.64607e-10	1	1	0
MYH8	4626	broad.mit.edu	37	17	10297607	10297607	+	Missense_Mutation	SNP	G	G	T	rs148425060		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:10297607G>T	ENST00000403437.2	-	35	5219	c.5125C>A	c.(5125-5127)Ctc>Atc	p.L1709I	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1709					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.L1709F(1)		NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GCATCCAGGAGCTCCTGTTCG	0.542000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				17	143					1.02788e-11	1.33223e-11	1	1	0
PITPNM1	9600	broad.mit.edu	37	11	67259700	67259700	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:67259700G>A	ENST00000356404.3	-	24	3764	c.3539C>T	c.(3538-3540)tCg>tTg	p.S1180L	PITPNM1_ENST00000534749.1_Missense_Mutation_p.S1180L|PITPNM1_ENST00000436757.2_Missense_Mutation_p.S1179L	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	1180					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						CGGGGGTCCCGAGGAGGCATG	0.672000													7	29					0	0	1	0	0
WASF3	10810	broad.mit.edu	37	13	27254301	27254301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr13:27254301C>T	ENST00000361042.4	+	7	895	c.670C>T	c.(670-672)Cag>Tag	p.Q224*	WASF3_ENST00000335327.5_Intron			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	222					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GAAACTGGAGCAGGCAGGGAG	0.493000													4	45					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4323004	4323004	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr4:4323004G>T	ENST00000337872.4	+	8	2380	c.2259G>T	c.(2257-2259)gcG>gcT	p.A753A	ZBTB49_ENST00000355834.3_Silent_p.A631A|ZBTB49_ENST00000538529.1_Silent_p.A236A	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						GGGGGCTAGCGATGAAGACGC	0.542000													6	34					8.12818e-05	9.06605e-05	1	1	0
PCDHGA11	56105	broad.mit.edu	37	5	140801028	140801028	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:140801028G>A	ENST00000398587.2	+	1	267	c.234G>A	c.(232-234)gtG>gtA	p.V78V	PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000518882.1_Silent_p.V78V|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTCGCTGTGAATCCGCGAA	0.587000													9	89					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101296580	101296580	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:101296580C>T	ENST00000369162.2	-	4	589	c.245G>A	c.(244-246)gGa>gAa	p.G82E	ASCC3_ENST00000522650.1_Missense_Mutation_p.G82E	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		ATTATCAGTTCCAACTATTCA	0.368000													10	49					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237632425	237632425	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:237632425C>A	ENST00000366574.2	+	17	1963	c.1646C>A	c.(1645-1647)gCt>gAt	p.A549D	RYR2_ENST00000360064.6_Missense_Mutation_p.A547D|RYR2_ENST00000542537.1_Missense_Mutation_p.A533D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	549					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAAACTGTGCTCAATTTTCT	0.373000													8	73					7.48243e-07	8.94806e-07	1	1	0
KLF11	8462	broad.mit.edu	37	2	10187792	10187792	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:10187792C>G	ENST00000535335.1	+	3	493	c.277C>G	c.(277-279)Cag>Gag	p.Q93E	KLF11_ENST00000540845.1_Missense_Mutation_p.Q93E|KLF11_ENST00000305883.1_Missense_Mutation_p.Q110E	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	110					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		AACTCCTCCTCAGAGCCCTGA	0.423000													18	100					0	0	1	0	0
TPGS2	25941	broad.mit.edu	37	18	34380235	34380235	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr18:34380235C>T	ENST00000334295.4	-	5	849	c.422G>A	c.(421-423)cGc>cAc	p.R141H	TPGS2_ENST00000593035.1_Missense_Mutation_p.R106H|TPGS2_ENST00000383056.3_Missense_Mutation_p.R98H|TPGS2_ENST00000589049.1_Missense_Mutation_p.R141H|TPGS2_ENST00000587129.1_Missense_Mutation_p.R141H|TPGS2_ENST00000590842.1_Missense_Mutation_p.R141H	NM_015476.2	NP_056291.2	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	141						cytoplasm|microtubule											TATCACACTGCGAGAGTCAAA	0.428000													13	211					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755838	242755838	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:242755838C>T	ENST00000391969.2	+	3	868	c.157C>T	c.(157-159)Cgc>Tgc	p.R53C	NEU4_ENST00000407683.1_Missense_Mutation_p.R53C|NEU4_ENST00000325935.6_Missense_Mutation_p.R66C|NEU4_ENST00000405370.1_Missense_Mutation_p.R53C|NEU4_ENST00000404257.1_Missense_Mutation_p.R65C	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	53						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CCACGCCCACCGCCTGGTGCT	0.736000													4	14					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34242536	34242536	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr20:34242536G>A	ENST00000374114.3	-	3	972	c.709C>T	c.(709-711)Cca>Tca	p.P237S	RBM12_ENST00000374104.3_Missense_Mutation_p.P237S|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397443.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.P237S	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	237	Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGTGGCAGTGGGGTCATGGGT	0.572000													17	83					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228996724	228996724	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:228996724G>A	ENST00000392056.3	-	2	156	c.110C>T	c.(109-111)cCg>cTg	p.P37L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P37L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	37						cytoplasm	protein binding	p.P37Q(2)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGAGTTCCCCGGGCCGCTTCC	0.468000													10	75					0	0	1	0	0
MPZL3	196264	broad.mit.edu	37	11	118106221	118106221	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:118106221C>T	ENST00000278949.4	-	4	590	c.535G>A	c.(535-537)Gtg>Atg	p.V179M	MPZL3_ENST00000527472.1_Missense_Mutation_p.V167M|MPZL3_ENST00000525386.1_Intron			Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3	179					cell adhesion	integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CCCATTCTCACCAGCAGCAGA	0.537000													33	179					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30034216	30034216	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:30034216C>A	ENST00000328224.6	-	2	1243	c.10G>T	c.(10-12)Gca>Tca	p.A4S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	4						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTCACCATTGCAACCTCCATG	0.522000													22	100					2.70639e-06	3.20349e-06	1	1	0
FRMPD2	143162	broad.mit.edu	37	10	49457143	49457143	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:49457143G>C	ENST00000374201.3	-	3	532	c.230C>G	c.(229-231)tCt>tGt	p.S77C	FRMPD2_ENST00000407470.4_Missense_Mutation_p.S68C|FRMPD2_ENST00000305531.3_Missense_Mutation_p.S75C	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	77	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CTCTATATGAGAAACACGGCC	0.537000													5	35					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37331816	37331816	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:37331816C>G	ENST00000231498.3	-	14	1803	c.1600G>C	c.(1600-1602)Gag>Cag	p.E534Q	NUP155_ENST00000513532.1_Missense_Mutation_p.E534Q|NUP155_ENST00000381843.2_Missense_Mutation_p.E475Q	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	534					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTTCAATCTCTTCTCCATCT	0.318000													9	128					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95670315	95670315	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:95670315C>T	ENST00000298912.4	-	9	1484	c.1371G>A	c.(1369-1371)ttG>ttA	p.L457L		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	457						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		CATCCTGCCTCAATGATTCCT	0.483000													5	77					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176798011	176798011	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:176798011G>T	ENST00000408923.3	+	11	1421	c.1233G>T	c.(1231-1233)ccG>ccT	p.P411P		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	411	Necessary for interaction with RABGEF1 (By similarity).|RBD 2.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTTGAGCCCGCTAGAGGTGG	0.776000													6	17					0.00116845	0.0012266	1	1	0
C16orf11	146325	broad.mit.edu	37	16	614977	614977	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:614977C>T	ENST00000409413.3	+	3	1665	c.1386C>T	c.(1384-1386)gaC>gaT	p.D462D		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	462										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						GGCCGCCAGACGCACCCCTCG	0.726000													3	13					0	0	1	0	0
HIST1H2AK	8330	broad.mit.edu	37	6	27805758	27805758	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:27805758T>A	ENST00000330180.2	-	1	359	c.360A>T	c.(358-360)aaA>aaT	p.K120N		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	120					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						GGCTCTCAGTTTTCTTAGGCA	0.547000													10	149					0	0	1	0	0
RUFY3	22902	broad.mit.edu	37	4	71628358	71628358	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr4:71628358C>T	ENST00000226328.4	+	2	864	c.301C>T	c.(301-303)Ctc>Ttc	p.L101F	RUFY3_ENST00000536664.1_Missense_Mutation_p.L85F|RUFY3_ENST00000381006.3_Missense_Mutation_p.L101F|RUFY3_ENST00000502653.1_Missense_Mutation_p.L48F|RUFY3_ENST00000417478.2_Missense_Mutation_p.L161F	NM_014961.3	NP_055776.1	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3	101	RUN.				negative regulation of axonogenesis	filopodium|growth cone				endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	16		all_hematologic(202;0.248)	Lung(101;0.235)			CTATGCACCTCTCCAGCAATT	0.473000													14	172					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7820939	7820939	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:7820939C>T	ENST00000379562.3	-	5	467	c.420G>A	c.(418-420)caG>caA	p.Q140Q	KIN_ENST00000535925.1_Silent_p.Q140Q|KIN_ENST00000543003.1_Silent_p.Q34Q			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	140					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TGTCTATGTACTGAATATACC	0.393000													11	182					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28214286	28214286	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:28214286C>A	ENST00000344423.5	-	4	615	c.484G>T	c.(484-486)Gca>Tca	p.A162S	ZNF395_ENST00000523095.1_Missense_Mutation_p.A162S|ZNF395_ENST00000523202.1_Missense_Mutation_p.A162S	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	162					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		ATTTCCACTGCGTCCGACTTC	0.572000													6	40					3.59834e-05	4.07226e-05	1	1	0
CAV1	857	broad.mit.edu	37	7	116199313	116199313	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:116199313T>C	ENST00000341049.2	+	3	787	c.509T>C	c.(508-510)gTc>gCc	p.V170A	CAV1_ENST00000393467.1_Missense_Mutation_p.V139A|CAV1_ENST00000405348.1_Missense_Mutation_p.V139A|CAV1_ENST00000393468.1_Missense_Mutation_p.V139A|CAV1_ENST00000393470.1_Missense_Mutation_p.V159A	NM_001753.4	NP_001744.2	Q03135	CAV1_HUMAN	caveolin 1, caveolae protein, 22kDa	170					blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			TTCAGCAATGTCCGCATCAAC	0.393000													11	70					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38840728	38840728	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:38840728G>T	ENST00000359357.3	+	49	6887	c.6633G>T	c.(6631-6633)tgG>tgT	p.W2211C	DNAH8_ENST00000449981.2_Missense_Mutation_p.W2428C|DNAH8_ENST00000441566.1_Missense_Mutation_p.W2175C					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGCCATCTGGATTGAGAACT	0.363000													8	103					0.27861	0.281033	1	1	0
TXNDC9	10190	broad.mit.edu	37	2	99938575	99938575	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:99938575C>G	ENST00000264255.3	-	4	661	c.406G>C	c.(406-408)Gag>Cag	p.E136Q	TXNDC9_ENST00000409434.1_Missense_Mutation_p.E136Q|C2orf15_ENST00000465095.1_Intron	NM_005783.3	NP_005774.2	O14530	TXND9_HUMAN	thioredoxin domain containing 9	136	Thioredoxin.				cell redox homeostasis		protein binding			lung(1)	1						TGCAGTCTCTCACAAAGGAAA	0.393000													8	140					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339921	55339921	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:55339921C>A	ENST00000314634.3	+	1	318	c.318C>A	c.(316-318)ggC>ggA	p.G106G		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				ATGTCTTTGGCTGCCTGGAGA	0.488000													41	220					4.92203e-23	6.96287e-23	1	1	0
USH2A	7399	broad.mit.edu	37	1	216062216	216062216	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:216062216G>T	ENST00000366943.2	-	41	8161	c.7775C>A	c.(7774-7776)cCa>cAa	p.P2592Q	RP5-1111A8.3_ENST00000414995.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.P2592Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2592	Fibronectin type-III 12.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGCAGTGTATGGGTGTAAATG	0.448000										HNSCC(13;0.011)			20	191					2.4624e-09	3.10476e-09	1	1	0
UBAP2	55833	broad.mit.edu	37	9	33923274	33923274	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr9:33923274G>A	ENST00000379238.1	-	26	3031	c.2914C>T	c.(2914-2916)Cag>Tag	p.Q972*	UBAP2_ENST00000379239.4_Nonsense_Mutation_p.Q705*|UBAP2_ENST00000449054.1_Nonsense_Mutation_p.Q972*|UBAP2_ENST00000360802.1_Nonsense_Mutation_p.Q972*|UBAP2_ENST00000379235.1_Nonsense_Mutation_p.Q211*|UBAP2_ENST00000539807.1_Nonsense_Mutation_p.Q727*			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	972										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GCTGTCCCCTGGGTCAGGTCG	0.557000													13	170					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25673328	25673328	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr4:25673328G>A	ENST00000382051.3	+	9	1083	c.1033G>A	c.(1033-1035)Gag>Aag	p.E345K	SLC34A2_ENST00000504570.1_Missense_Mutation_p.E344K|SLC34A2_ENST00000503434.1_Missense_Mutation_p.E344K	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	345					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GACCTACAAGGAGAACATCGC	0.502000			T	ROS1	NSCLC								45	215					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129049354	129049354	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:129049354A>G	ENST00000325006.3	+	11	1387	c.1333A>G	c.(1333-1335)Atc>Gtc	p.I445V	AHCYL2_ENST00000446212.1_Missense_Mutation_p.I343V|AHCYL2_ENST00000474594.1_Missense_Mutation_p.I342V|AHCYL2_ENST00000531335.2_Missense_Mutation_p.I364V|AHCYL2_ENST00000490911.1_Missense_Mutation_p.I342V|AHCYL2_ENST00000446544.2_Missense_Mutation_p.I444V	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	445					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						AAATGAGGTCATCCGACAAGT	0.408000													20	110					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74914025	74914025	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:74914025T>C	ENST00000372979.4	-	6	978	c.772A>G	c.(772-774)Ata>Gta	p.I258V	ECD_ENST00000454759.1_Missense_Mutation_p.I258V|ECD_ENST00000430082.1_Missense_Mutation_p.I258V	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	258					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					GATGTCATTATTCGTGTTTCA	0.408000													15	55					0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8609872	8609872	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr18:8609872C>A	ENST00000329286.6	+	1	430	c.147C>A	c.(145-147)ggC>ggA	p.G49G		NM_001025300.2	NP_001020471.2	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	49					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding	p.G49G(1)		breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						TCATTATCGGCTCCCGCGGCG	0.711000													8	21					1.12685e-05	1.32035e-05	1	1	0
TRIML1	339976	broad.mit.edu	37	4	189068512	189068512	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr4:189068512A>T	ENST00000332517.3	+	6	1533	c.1393A>T	c.(1393-1395)Aac>Tac	p.N465Y	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	465	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTGCTCACTGAACAGCCACGT	0.552000													11	104					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18659367	18659367	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:18659367A>G	ENST00000308799.4	+	5	1438	c.1219A>G	c.(1219-1221)Aac>Gac	p.N407D	FBXW10_ENST00000301938.4_Missense_Mutation_p.N378D|FBXW10_ENST00000395667.1_Missense_Mutation_p.N378D|FBXW10_ENST00000395665.4_Missense_Mutation_p.N378D			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	378								p.N378D(2)		NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						GAATGAGTACAACCTGTGGAC	0.478000													4	44					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039930	31039930	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:31039930C>A	ENST00000355537.3	+	4	3551	c.3404C>A	c.(3403-3405)cCt>cAt	p.P1135H		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AACAAGGAGCCTGATGGAAAG	0.527000													11	70					1.08611e-07	1.32619e-07	1	1	0
FMO2	2327	broad.mit.edu	37	1	171168556	171168556	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:171168556C>T	ENST00000441535.1	+	5	673	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	RP1-127D3.4_ENST00000445290.1_RNA|FMO2_ENST00000209929.7_Missense_Mutation_p.R186C|FMO2_ENST00000529935.1_Intron|RP1-127D3.4_ENST00000422841.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|RP1-45C12.1_ENST00000455124.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	186					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGAGGGAAAACGCATCCTGGT	0.473000													10	189					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52366204	52366204	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:52366204C>A	ENST00000356297.4	-	10	1224	c.1124G>T	c.(1123-1125)aGg>aTg	p.R375M	PXDNL_ENST00000543296.1_Missense_Mutation_p.R375M	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	375	Ig-like C2-type 2.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGCCACGTGCCTGGATCCATC	0.502000													13	81					2.27111e-07	2.74426e-07	1	1	0
SKI	6497	broad.mit.edu	37	1	2160607	2160607	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:2160607C>T	ENST00000378536.4	+	1	474	c.402C>T	c.(400-402)ttC>ttT	p.F134F		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	134					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		TGCGCGACTTCTCGCTGCAGC	0.622000													3	24					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44763242	44763242	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:44763242G>T	ENST00000296091.4	+	4	1189	c.933G>T	c.(931-933)acG>acT	p.T311T	ZNF502_ENST00000449836.1_Silent_p.T311T|ZNF502_ENST00000436624.2_Silent_p.T311T	NM_001134440.1|NM_033210.4	NP_001127912.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T311T(1)		NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		CAAATCTTACGCAACATCAGA	0.403000													47	244					5.37117e-13	7.04018e-13	1	1	0
AKAP6	9472	broad.mit.edu	37	14	33014449	33014449	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:33014449C>T	ENST00000280979.4	+	4	760	c.590C>T	c.(589-591)tCt>tTt	p.S197F	AKAP6_ENST00000557272.1_Missense_Mutation_p.S197F|AKAP6_ENST00000557354.1_Missense_Mutation_p.S197F	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	197					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGGCTTGATTCTCTAACAGAA	0.403000													13	101					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065769	9065769	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:9065769G>C	ENST00000397910.4	-	3	21880	c.21677C>G	c.(21676-21678)tCa>tGa	p.S7226*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7228	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGAGGGGTTGATATGGCAAC	0.478000													29	204					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133035010	133035010	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:133035010C>A	ENST00000367928.4	-	1	178	c.165G>T	c.(163-165)cgG>cgT	p.R55R		NM_004666.2	NP_004657.2	O95497	VNN1_HUMAN	vanin 1	55	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			NS(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	31	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		TGTCCAGATTCCGATTCATTA	0.488000													25	137					3.01185e-09	3.77702e-09	1	1	0
STIM1	6786	broad.mit.edu	37	11	3988913	3988913	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:3988913G>T	ENST00000300737.4	+	2	839		c.e2+1		STIM1_ENST00000527651.1_Splice_Site	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1						activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		AAGTGATGAGGTGAGCTCTCC	0.478000													21	76					1.87028e-06	2.22516e-06	1	1	0
WHAMMP3	339005	broad.mit.edu	37	15	23205184	23205184	+	RNA	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:23205184G>A	ENST00000400153.2	-	0	670					NR_003521.1																						TGGCTTTTCGGTGTCCTTGAA	0.403000													3	23					0	0	1	0	0
CASC10	399726	broad.mit.edu	37	10	21784583	21784583	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:21784583G>A	ENST00000377113.5	-	2	804	c.357C>T	c.(355-357)ctC>ctT	p.L119L		NM_001010911.2	NP_001010911.1			cancer susceptibility candidate 10																		AGTCCTGGATGAGAGGTAGGG	0.587000											OREG0020066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	82					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383184	108383184	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:108383184G>C	ENST00000265843.4	-	6	3160	c.3050C>G	c.(3049-3051)aCa>aGa	p.T1017R	EXPH5_ENST00000443411.1_Missense_Mutation_p.T829R|EXPH5_ENST00000525344.1_Missense_Mutation_p.T1010R|EXPH5_ENST00000428840.1_Missense_Mutation_p.T941R	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1017					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ACAATAAATTGTGTCAAGTTC	0.398000													17	106					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502637	20502637	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:20502637C>A	ENST00000315693.2	-	1	282	c.281G>T	c.(280-282)tGg>tTg	p.W94L		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ACATCCCCACCATGAGATGGT	0.458000													9	92					2.17888e-05	2.50247e-05	1	1	0
WTAP	9589	broad.mit.edu	37	6	160174524	160174524	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:160174524G>C	ENST00000358372.4	+	7	2242	c.485G>C	c.(484-486)cGa>cCa	p.R162P	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	162					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GCGAAGTGTCGAATGCTTATC	0.428000													8	75					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2602389	2602389	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:2602389C>T	ENST00000399655.1	+	7	1215	c.950C>T	c.(949-951)gCg>gTg	p.A317V	CACNA1C_ENST00000399644.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000406454.3_Missense_Mutation_p.A317V|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A317V|CACNA1C_ENST00000399629.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399637.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399641.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399603.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000347598.4_Missense_Mutation_p.A317V|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399621.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A317V|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A317V|CACNA1C_ENST00000399617.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A317V|CACNA1C_ENST00000399634.1_Missense_Mutation_p.A317V|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A317V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	317					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCCCTTGTGCGCTGGAAACG	0.592000													13	116					0	0	1	0	0
FANCB	2187	broad.mit.edu	37	X	14882880	14882880	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:14882880C>T	ENST00000398334.1	-	3	1020	c.753G>A	c.(751-753)caG>caA	p.Q251Q	FANCB_ENST00000324138.3_Silent_p.Q251Q	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	251					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					ATATTCTTAACTGGTTTTTGA	0.363000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	70					0	0	1	0	0
JRK	8629	broad.mit.edu	37	8	143747138	143747138	+	RNA	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:143747138C>T	ENST00000507178.2	-	0	672									jerky homolog (mouse)													all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				ttggccttctcgatgagcatg	0.617000													5	19					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107048022	107048022	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:107048022G>C	ENST00000392842.1	+	4	622	c.208G>C	c.(208-210)Gag>Cag	p.E70Q	RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Missense_Mutation_p.E79Q	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	70					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GGAGAACTATGAGATTGCAGA	0.483000													8	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083393	9083393	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:9083393A>C	ENST00000397910.4	-	1	8625	c.8422T>G	c.(8422-8424)Tca>Gca	p.S2808A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2808	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCCAGTTGAGTGAGTGGAC	0.507000													7	37					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61180201	61180201	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:61180201T>C	ENST00000216513.4	-	3	2329	c.2270A>G	c.(2269-2271)gAa>gGa	p.E757G		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	757						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		TTCCAGGTCTTCACAGACAGT	0.398000													12	97					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76259285	76259285	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:76259285G>T	ENST00000274368.4	+	6	1233	c.811_splice	c.e6+1	p.A271_splice	CRHBP_ENST00000514258.1_3'UTR	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	271					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TCATGGCCCGGGTGAGGTATT	0.443000													46	167					1.51926e-22	2.13617e-22	1	1	0
RYR2	6262	broad.mit.edu	37	1	237659945	237659945	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:237659945C>A	ENST00000366574.2	+	20	2413	c.2096C>A	c.(2095-2097)tCc>tAc	p.S699Y	RYR2_ENST00000360064.6_Missense_Mutation_p.S697Y|RYR2_ENST00000542537.1_Missense_Mutation_p.S683Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	699	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCTGGGCTTCCACTGAAGGA	0.507000													20	153					1.33834e-09	1.69669e-09	1	1	0
HOXA1	3198	broad.mit.edu	37	7	27134229	27134229	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:27134229G>C	ENST00000343060.4	-	2	899	c.838C>G	c.(838-840)Cgc>Ggc	p.R280G	HOXA1_ENST00000355633.5_3'UTR	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	280						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TTCATTCGGCGGTTCTGGAAC	0.577000													13	71					0	0	1	0	0
OCEL1	79629	broad.mit.edu	37	19	17337064	17337064	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:17337064A>G	ENST00000215061.4	+	1	52	c.8A>G	c.(7-9)aAc>aGc	p.N3S	OCEL1_ENST00000601529.1_Missense_Mutation_p.N3S|OCEL1_ENST00000601576.1_3'UTR	NM_024578.1	NP_078854.1	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	3										central_nervous_system(2)|endometrium(2)|kidney(1)|lung(2)	7						TAAATGCACAACCCGGACGGA	0.701000													3	13					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141182	63141182	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:63141182C>A	ENST00000279178.3	+	3	822	c.573C>A	c.(571-573)gcC>gcA	p.A191A	SLC22A9_ENST00000310969.4_Intron	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	191					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CCTGTGCAGCCTTGGCTCCCA	0.463000													32	144					2.46105e-21	3.41895e-21	1	1	0
RYR3	6263	broad.mit.edu	37	15	33988480	33988480	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:33988480G>T	ENST00000389232.4	+	39	5992	c.5922G>T	c.(5920-5922)caG>caT	p.Q1974H	RYR3_ENST00000415757.3_Missense_Mutation_p.Q1974H	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1974	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCAGATCCAGGATTCAGAGC	0.567000													10	65					4.68919e-08	5.78666e-08	1	1	0
HOXB13	10481	broad.mit.edu	37	17	46804384	46804384	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:46804384G>T	ENST00000290295.7	-	2	1207	c.623C>A	c.(622-624)cCt>cAt	p.P208H		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	208					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GCAGGCGTCAGGAGGGTGCTG	0.627000													16	80					6.49762e-13	8.46881e-13	1	1	0
KCTD18	130535	broad.mit.edu	37	2	201371684	201371684	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:201371684C>A	ENST00000359878.3	-	2	566	c.56G>T	c.(55-57)gGt>gTt	p.G19V	KCTD18_ENST00000409157.1_Missense_Mutation_p.G19V|KCTD18_ENST00000468413.1_5'UTR	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	19	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						AATACAGCCACCCACGTTCAG	0.517000													12	43					1.49906e-05	1.73026e-05	1	1	0
LSG1	55341	broad.mit.edu	37	3	194373598	194373598	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:194373598C>T	ENST00000265245.5	-	8	1347	c.1033G>A	c.(1033-1035)Gag>Aag	p.E345K		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	345					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CTCCGAGCCTCAGAATCTGCA	0.522000													16	218					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059448	59059448	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:59059448C>G	ENST00000361488.3	+	5	1539	c.659C>G	c.(658-660)tCt>tGt	p.S220C	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	220						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TGCAGTAGCTCTGCCCCTCCC	0.632000													7	126					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67365761	67365761	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr18:67365761G>T	ENST00000382713.5	+	5	721	c.531G>T	c.(529-531)gtG>gtT	p.V177V	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	177	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TCAAACTGGTGATGTGGCCTC	0.478000													6	55					0.000157383	0.000173871	1	1	0
MEIS1	4211	broad.mit.edu	37	2	66798499	66798499	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:66798499C>A	ENST00000407092.2	+	12	1693	c.1236C>A	c.(1234-1236)ccC>ccA	p.P412P	MEIS1_ENST00000272369.9_3'UTR|MEIS1_ENST00000488550.1_3'UTR|MEIS1_ENST00000444274.2_3'UTR|MEIS1_ENST00000398506.2_Silent_p.P410P|MEIS1_ENST00000495021.2_3'UTR			O00470	MEIS1_HUMAN	Meis homeobox 1	43							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						GTCATGGGCCCCCCATGCATA	0.587000													6	15					5.9392e-07	7.13935e-07	1	1	0
DDX4	54514	broad.mit.edu	37	5	55094338	55094338	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:55094338C>T	ENST00000505374.1	+	18	1646	c.1554C>T	c.(1552-1554)acC>acT	p.T518T	DDX4_ENST00000511853.1_Silent_p.T369T|DDX4_ENST00000353507.5_Silent_p.T484T|DDX4_ENST00000354991.5_Silent_p.T484T|DDX4_ENST00000514278.2_Silent_p.T498T	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	518					multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTCAGCAGACCGTTCTCCAAG	0.378000													24	169					0	0	1	0	0
CXorf66	347487	broad.mit.edu	37	X	139038638	139038638	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:139038638G>A	ENST00000370540.1	-	3	526	c.503C>T	c.(502-504)tCa>tTa	p.S168L		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	168	Ser-rich.					integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						TTTTGAGCATGATGACTTGGA	0.393000													13	250					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227749	75227749	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:75227749C>T	ENST00000342232.4	-	2	526	c.486G>A	c.(484-486)tcG>tcA	p.S162S		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	162					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GCGAGGCCAGCGAGGTACGCA	0.731000													6	36					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25762221	25762221	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:25762221G>T	ENST00000377905.4	+	2	150	c.31G>T	c.(31-33)Gtg>Ttg	p.V11L	SLC17A4_ENST00000439485.2_Missense_Mutation_p.V11L|SLC17A4_ENST00000397076.2_5'UTR	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	11					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CAAGGCTACAGTGGGGGACAT	0.403000													8	69					0.00621372	0.00640703	1	1	0
TAL1	6886	broad.mit.edu	37	1	47685502	47685502	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:47685502C>A	ENST00000371883.3	-	4	1468	c.892G>T	c.(892-894)Gat>Tat	p.D298Y	TAL1_ENST00000371884.2_Missense_Mutation_p.D296Y|TAL1_ENST00000294339.3_Missense_Mutation_p.D296Y|TAL1_ENST00000459729.1_5'UTR			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	296					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						GCTGCCCCATCCAGGGAGCTG	0.726000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								6	46					8.12818e-05	9.06605e-05	1	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86547826	86547826	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:86547826C>T	ENST00000450689.2	-	12	1710	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.E342K|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.E509K|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.E269K|KIAA1324L_ENST00000490995.1_5'UTR	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	509						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CTTCCTAGTTCAGAACCCGTG	0.378000													7	92					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407139	38407139	+	Silent	SNP	T	T	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:38407139T>A	ENST00000322350.5	+	8	1384	c.1038T>A	c.(1036-1038)ccT>ccA	p.P346P	EGFLAM_ENST00000336740.6_Silent_p.P112P|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000354891.3_Silent_p.P346P	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	346	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TTGACATGCCTTGTGATGAAA	0.557000													28	119					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67365762	67365762	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr18:67365762A>T	ENST00000382713.5	+	5	722	c.532A>T	c.(532-534)Atg>Ttg	p.M178L	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	178	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				CAAACTGGTGATGTGGCCTCT	0.478000													6	54					0	0	1	0	0
VPS26A	9559	broad.mit.edu	37	10	70892681	70892681	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:70892681A>T	ENST00000373382.1	+	3	684	c.31A>T	c.(31-33)Att>Ttt	p.I11F	VPS26A_ENST00000490696.1_3'UTR|VPS26A_ENST00000546041.1_5'UTR|VPS26A_ENST00000489794.1_5'UTR|VPS26A_ENST00000541711.1_5'UTR|VPS26A_ENST00000395098.1_Missense_Mutation_p.I11F|VPS26A_ENST00000263559.6_Missense_Mutation_p.I11F			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	11					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						TTTTGGTCCAATTTGTGAGAT	0.303000													7	83					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27185160	27185160	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:27185160C>A	ENST00000335625.5	+	9	1701	c.813C>A	c.(811-813)acC>acA	p.T271T	GABRA5_ENST00000400081.3_Silent_p.T271T|GABRA5_ENST00000355395.5_Silent_p.T271T	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	271					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCATAATGACCGTGATCTTAT	0.498000													9	39					0.000274275	0.00030015	1	1	0
STIL	6491	broad.mit.edu	37	1	47767372	47767372	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:47767372T>A	ENST00000360380.3	-	6	677	c.314A>T	c.(313-315)gAa>gTa	p.E105V	STIL_ENST00000396221.2_Missense_Mutation_p.E105V|STIL_ENST00000243182.6_Missense_Mutation_p.E105V|STIL_ENST00000371877.3_Missense_Mutation_p.E105V|STIL_ENST00000337817.5_Missense_Mutation_p.E105V			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	105					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTCAGGTACTTCTCGACCAGG	0.363000													12	73					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58001239	58001239	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:58001239C>A	ENST00000548198.1	+	3	2097	c.593C>A	c.(592-594)gCc>gAc	p.A198D	DTX3_ENST00000551632.1_Missense_Mutation_p.A201D|DTX3_ENST00000337737.3_Missense_Mutation_p.A198D|DTX3_ENST00000548804.1_Missense_Mutation_p.A198D			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	198					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					GTGAAAAAGGCCTGCCCCATG	0.617000													12	18					0.000978159	0.00104098	1	1	0
B4GALT3	8703	broad.mit.edu	37	1	161145756	161145756	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:161145756C>T	ENST00000319769.5	-	3	317	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	B4GALT3_ENST00000367998.1_Missense_Mutation_p.R32Q|PPOX_ENST00000432542.2_Intron|B4GALT3_ENST00000470882.1_5'UTR|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000495483.1_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	32					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	ACTGAGACTTCGGAAGCCCCC	0.602000													10	205					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23403743	23403743	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:23403743C>T	ENST00000307149.5	-	16	2289	c.2104G>A	c.(2104-2106)Gag>Aag	p.E702K	COG7_ENST00000569635.1_Intron	NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	702					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GGGCTCAGCTCAGGGATCTGT	0.597000													7	73					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597342.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													4	23					0.150653	0.152627	1	1	0
CCDC13	152206	broad.mit.edu	37	3	42751244	42751244	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:42751244C>A	ENST00000310232.6	-	15	2003	c.1920G>T	c.(1918-1920)aaG>aaT	p.K640N		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	640										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						ATGGGTCCTTCTTCTCGCTCC	0.597000													17	112					4.75885e-15	6.45645e-15	1	1	0
HELZ	9931	broad.mit.edu	37	17	65144705	65144705	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:65144705G>A	ENST00000358691.5	-	20	2767	c.2601C>T	c.(2599-2601)cgC>cgT	p.R867R	HELZ_ENST00000580168.1_Silent_p.R868R	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTTCATGGGAGCGGTAGTTCT	0.488000													58	220					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65054903	65054903	+	Silent	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:65054903C>T	ENST00000298705.1	+	11	1068	c.972C>T	c.(970-972)ctC>ctT	p.L324L	RP11-973N13.3_ENST00000556634.1_RNA|RP11-973N13.3_ENST00000554454.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	324																	TGCCATCTCTCAGAGAAAAAG	0.463000													13	153					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1413249	1413249	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:1413249C>A	ENST00000381524.3	+	8	861	c.675C>A	c.(673-675)acC>acA	p.T225T	CSF2RA_ENST00000498153.1_3'UTR|CSF2RA_ENST00000355432.3_Silent_p.T225T|CSF2RA_ENST00000381500.1_Silent_p.T225T|CSF2RA_ENST00000361536.3_Silent_p.T225T|CSF2RA_ENST00000381529.3_Silent_p.T225T|CSF2RA_ENST00000381509.3_Silent_p.T225T|CSF2RA_ENST00000417535.2_Silent_p.T225T|CSF2RA_ENST00000501036.2_Silent_p.T92T|CSF2RA_ENST00000432318.2_Silent_p.T225T|CSF2RA_ENST00000355805.2_Intron			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	225						extracellular region|integral to plasma membrane	cytokine receptor activity	p.T225T(3)		central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCAATGTCACCGTACGTTGCA	0.577000													34	198					3.76114e-14	5.04384e-14	1	1	0
RGPD3	653489	broad.mit.edu	37	2	107041575	107041575	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:107041575G>T	ENST00000409886.3	-	20	2935	c.2848C>A	c.(2848-2850)Cag>Aag	p.Q950K	RGPD3_ENST00000304514.7_Missense_Mutation_p.Q950K	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	950					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CTAATATCCTGAGCCTGTAAG	0.423000													90	414					5.48297e-45	7.85215e-45	1	1	0
ZNF728	388523	broad.mit.edu	37	19	23159438	23159438	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:23159438C>G	ENST00000594710.1	-	4	846	c.701G>C	c.(700-702)gGc>gCc	p.G234A		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		AAAGGCTTTGCCACATTCTTC	0.398000													12	64					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269378	53269378	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:53269378T>G	ENST00000338230.3	-	3	1898	c.1631A>C	c.(1630-1632)cAt>cCt	p.H544P		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		AAGTCTACGATGGCAATGAAG	0.448000													27	327					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155340428	155340428	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:155340428C>G	ENST00000368346.3	-	12	7207	c.6568G>C	c.(6568-6570)Gag>Cag	p.E2190Q	ASH1L_ENST00000392403.3_Missense_Mutation_p.E2185Q			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2190	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGATACTGCTCAATCATCCTG	0.393000													7	127					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4942171	4942171	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:4942171C>T	ENST00000345988.2	-	15	1783	c.1694G>A	c.(1693-1695)cGg>cAg	p.R565Q	PPL_ENST00000590782.2_Missense_Mutation_p.R563Q	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	565					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						AGCCGTGCTCCGCGTCTTCTC	0.627000													6	58					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419084	55419084	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:55419084C>A	ENST00000312422.2	+	1	705	c.705C>A	c.(703-705)ctC>ctA	p.L235L		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GCAAAGCCCTCTCCACCTGTG	0.493000													31	153					1.75199e-13	2.32263e-13	1	1	0
BRINP1	1620	broad.mit.edu	37	9	121929566	121929566	+	Silent	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr9:121929566G>C	ENST00000265922.3	-	8	2543	c.2082C>G	c.(2080-2082)ctC>ctG	p.L694L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		694					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CCAACAAGAGGAGCATCACTG	0.587000													12	167					0	0	1	0	0
DNAJC22	79962	broad.mit.edu	37	12	49743205	49743205	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:49743205C>T	ENST00000549441.2	+	3	1754	c.550C>T	c.(550-552)Cgt>Tgt	p.R184C	DNAJC22_ENST00000395069.3_Missense_Mutation_p.R184C			Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	184					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(1)|ovary(1)|pancreas(1)	10						GCGGCTCTATCGTCTGGGCTT	0.577000													8	118					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490508	65490508	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:65490508C>T	ENST00000261883.4	-	9	2282	c.2116G>A	c.(2116-2118)Ggg>Agg	p.G706R		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	706					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCCCACAGCCCTGTGTCTGGA	0.483000													9	144					0	0	1	0	0
GAS6	2621	broad.mit.edu	37	13	114535760	114535760	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr13:114535760T>A	ENST00000357389.3	-	9	1081	c.929A>T	c.(928-930)cAc>cTc	p.H310L	GAS6-AS1_ENST00000458001.1_RNA|GAS6_ENST00000327773.6_Intron|GAS6_ENST00000450766.1_Intron|GAS6_ENST00000418959.3_5'UTR|GAS6_ENST00000355761.4_Intron|GAS6_ENST00000480426.1_5'UTR			Q14393	GAS6_HUMAN	growth arrest-specific 6	310					cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				GTCGGGGATGTGGCCTTCACT	0.701000													30	48					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49598065	49598065	+	RNA	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:49598065A>T	ENST00000527477.1	+	0	669																											GCCCAACATCACACTGGGCTG	0.522000													7	24					0	0	1	0	0
SHOC2	8036	broad.mit.edu	37	10	112724813	112724813	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:112724813G>A	ENST00000369452.4	+	2	1042	c.697G>A	c.(697-699)Gaa>Aaa	p.E233K	SHOC2_ENST00000489390.1_Intron|SHOC2_ENST00000265277.5_Missense_Mutation_p.E233K	NM_007373.3	NP_031399.2	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog (C. elegans)	233					fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(2)	17				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		ACTACCTGCTGAAATTGGTAA	0.328000													4	54					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122334668	122334668	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:122334668G>A	ENST00000398250.1	+	6	823	c.471G>A	c.(469-471)acG>acA	p.T157T	PPAPDC1A_ENST00000369073.3_Silent_p.T147T|PPAPDC1A_ENST00000541332.1_Silent_p.T157T|PPAPDC1A_ENST00000439221.1_Silent_p.T94T|PPAPDC1A_ENST00000398248.1_Intron	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	157					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TTGGCTTCACGACGTTCTACT	0.597000													12	148					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45475126	45475126	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:45475126C>T	ENST00000372172.4	-	6	975	c.904G>A	c.(904-906)Gat>Aat	p.D302N		NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	302	DOC.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					AAGTTGTCATCTGTGGTATCC	0.547000													38	184					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891290	18891290	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:18891290G>T	ENST00000317658.3	+	1	246	c.88G>T	c.(88-90)Gcc>Tcc	p.A30S		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	30					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				ATTTGTAAATGCCTTTGATGA	0.458000													29	79					9.80776e-20	1.34639e-19	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2910135	2910135	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:2910135G>A	ENST00000520002.1	-	51	8067	c.7512C>T	c.(7510-7512)aaC>aaT	p.N2504N	CSMD1_ENST00000542608.1_Silent_p.N2503N|CSMD1_ENST00000400186.3_Silent_p.N2504N|CSMD1_ENST00000602723.1_Silent_p.N2504N|CSMD1_ENST00000537824.1_Silent_p.N2503N|CSMD1_ENST00000602557.1_Silent_p.N2504N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2504	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TAAATGAACCGTTTCCTGGGG	0.423000													4	21					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476170	120476170	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr9:120476170G>T	ENST00000355622.6	+	3	1865	c.1764G>T	c.(1762-1764)caG>caT	p.Q588H	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.Q548H	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	588	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GTGAACACCAGAGTTTCCTGC	0.428000													25	49					4.72057e-08	5.79457e-08	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2044236	2044236	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:2044236G>A	ENST00000262113.4	+	18	2416	c.2275G>A	c.(2275-2277)Gag>Aag	p.E759K	MYOM2_ENST00000523438.1_Missense_Mutation_p.E184K	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	759	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAACTGGCACGAGGTCAATTC	0.493000													11	84					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059389	248059389	+	Silent	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:248059389C>G	ENST00000537741.1	+	3	758	c.501C>G	c.(499-501)ccC>ccG	p.P167P	OR2W3_ENST00000360358.3_Silent_p.P167P			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGCGCTTACCCCGCTGTGGGC	0.642000													10	129					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86238081	86238081	+	Splice_Site	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:86238081C>T	ENST00000314673.3	-	20	2071		c.e20-1		SNX14_ENST00000513865.1_Intron|SNX14_ENST00000505648.1_Splice_Site|SNX14_ENST00000346348.3_Splice_Site|SNX14_ENST00000369627.2_Splice_Site|SNX14_ENST00000508980.1_Splice_Site	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14						cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GGAAATGCACCTGAAATTAGT	0.318000													9	124					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10709362	10709362	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:10709362G>A	ENST00000377022.3	-	14	3330	c.3013C>T	c.(3013-3015)Ccc>Tcc	p.P1005S	CASZ1_ENST00000344008.5_Missense_Mutation_p.P1005S|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1005					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		ACCTTCCAGGGCTCTGCCAAC	0.692000													4	13					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212560333	212560333	+	Silent	SNP	G	G	A	rs140199700		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:212560333G>A	ENST00000261455.4	-	3	380	c.243C>T	c.(241-243)gcC>gcT	p.A81A	TMEM206_ENST00000471937.1_5'UTR|TMEM206_ENST00000535273.1_Silent_p.A142A	NM_018252.2	NP_060722.2	Q9H813	TM206_HUMAN	transmembrane protein 206	81						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		CCAGAAAGACGGCCACAGCCA	0.547000													17	201					0	0	1	0	0
XRCC5	7520	broad.mit.edu	37	2	216990696	216990696	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:216990696G>T	ENST00000392133.3	+	9	1201	c.740G>T	c.(739-741)tGg>tTg	p.W247L	XRCC5_ENST00000392132.2_Missense_Mutation_p.W247L			P13010	XRCC5_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	247					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			endometrium(1)|kidney(3)|large_intestine(8)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		TCCATTCACTGGCCCTGCCGA	0.378000								Non-homologous end-joining					23	103					1.33986e-20	1.85029e-20	1	1	0
ELL2	22936	broad.mit.edu	37	5	95249609	95249609	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:95249609C>A	ENST00000237853.4	-	4	696	c.347G>T	c.(346-348)gGa>gTa	p.G116V	ELL2_ENST00000506628.1_Intron|ELL2_ENST00000431061.2_Missense_Mutation_p.G116V	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	116					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TTGTATAAATCCCAGGCAATT	0.433000													32	159					2.48696e-23	3.53972e-23	1	1	0
RYR2	6262	broad.mit.edu	37	1	237659946	237659946	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:237659946C>A	ENST00000366574.2	+	20	2414	c.2097C>A	c.(2095-2097)tcC>tcA	p.S699S	RYR2_ENST00000360064.6_Silent_p.S697S|RYR2_ENST00000542537.1_Silent_p.S683S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	699	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTGGGCTTCCACTGAAGGAT	0.502000													20	152					1.33834e-09	1.69669e-09	1	1	0
PLA2G6	8398	broad.mit.edu	37	22	38541632	38541632	+	Missense_Mutation	SNP	C	C	A	rs121908685		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr22:38541632C>A	ENST00000332509.3	-	3	421	c.238G>T	c.(238-240)Gcc>Tcc	p.A80S	PLA2G6_ENST00000402064.1_Missense_Mutation_p.A80S|PLA2G6_ENST00000335539.3_Missense_Mutation_p.A80S	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	80					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	TTCACTAGGGCGTCAGCCTCC	0.577000													5	15					0.000602214	0.000646823	1	1	0
POTEH	23784	broad.mit.edu	37	22	16266978	16266978	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr22:16266978T>C	ENST00000343518.6	-	9	1522	c.1471A>G	c.(1471-1473)Aca>Gca	p.T491A		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	491										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CTTTCAGGTGTTCTGCTTTTC	0.438000													11	242					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	22					0	0	1	0	0
SPNS2	124976	broad.mit.edu	37	17	4416587	4416587	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:4416587G>T	ENST00000329078.3	+	2	626	c.416G>T	c.(415-417)gGc>gTc	p.G139V		NM_001124758.1	NP_001118230.1	Q8IVW8	SPNS2_HUMAN	spinster homolog 2 (Drosophila)	139					lipid transport|transmembrane transport	integral to membrane				large_intestine(3)|lung(1)|prostate(1)|skin(1)	6						AAGGACCGAGGCGCCGGCCTG	0.662000													9	84					0.000673444	0.000719995	1	1	0
FAXC	84553	broad.mit.edu	37	6	99797120	99797120	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:99797120G>T	ENST00000389677.5	-	1	411	c.129C>A	c.(127-129)atC>atA	p.I43I		NM_032511.2	NP_115900.1	Q5TGI0	CF168_HUMAN	failed axon connections homolog (Drosophila)	43																	AAGGGAAAGCGATGATGTCCC	0.602000													10	66					0.335167	0.336618	1	1	0
NIPBL	25836	broad.mit.edu	37	5	36985251	36985251	+	Nonsense_Mutation	SNP	A	A	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:36985251A>T	ENST00000282516.8	+	10	2468	c.1969A>T	c.(1969-1971)Aga>Tga	p.R657*	NIPBL_ENST00000448238.2_Nonsense_Mutation_p.R657*|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	657					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAATGAGAGCAGAACAACTGA	0.338000													26	79					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13830888	13830888	+	Silent	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr20:13830888G>T	ENST00000284951.5	-	19	1970	c.1896C>A	c.(1894-1896)gcC>gcA	p.A632A	SEL1L2_ENST00000486903.1_5'UTR|SEL1L2_ENST00000378072.5_Silent_p.A519A			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	632						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						GTTTCATGACGGCAAAGAGCA	0.458000													9	78					1.12685e-05	1.32035e-05	1	1	0
POM121L9P	29774	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													4	32					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57803856	57803856	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:57803856G>T	ENST00000379655.4	-	8	1208	c.951C>A	c.(949-951)taC>taA	p.Y317*	KIFC3_ENST00000562903.1_Nonsense_Mutation_p.Y178*|KIFC3_ENST00000543930.1_Nonsense_Mutation_p.Y178*|KIFC3_ENST00000541240.1_Nonsense_Mutation_p.Y339*|KIFC3_ENST00000540079.2_Nonsense_Mutation_p.Y215*|KIFC3_ENST00000539578.1_Nonsense_Mutation_p.Y259*|KIFC3_ENST00000465878.2_Nonsense_Mutation_p.Y178*|KIFC3_ENST00000445690.2_Nonsense_Mutation_p.Y317*|KIFC3_ENST00000421376.2_Nonsense_Mutation_p.Y178*	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	317					epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				GCTCTGACTCGTACATGGCAA	0.607000													5	51					0.000602214	0.000646823	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25492350	25492350	+	RNA	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:25492350C>A	ENST00000453082.2	+	0	2811					NR_003343.1																						TGTTCCTGGGCCAGTGGCCAT	0.607000													10	52					0.0692343	0.0704489	1	1	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	46					0	0	1	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44037352	44037352	+	RNA	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr15:44037352G>A	ENST00000381680.2	-	0	271					NR_002318.2																						CTTCTTGTTGGTAAGCGGCCA	0.498000													30	224					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116757177	116757177	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr6:116757177G>T	ENST00000331677.3	+	7	1990	c.1546G>T	c.(1546-1548)Gac>Tac	p.D516Y	DSE_ENST00000537543.1_Missense_Mutation_p.D535Y|DSE_ENST00000452085.3_Missense_Mutation_p.D516Y|DSE_ENST00000359564.2_Missense_Mutation_p.D516Y			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	516					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity	p.D516N(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ATACAAGCATGACCTGGCAGC	0.502000													10	57					3.86212e-05	4.34957e-05	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139268941	139268941	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:139268941C>T	ENST00000395297.1	-	5	529	c.359G>A	c.(358-360)aGt>aAt	p.S120N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	120										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGCTGTTCACTGTCCGTAAA	0.463000										HNSCC(54;0.14)			17	35					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65372223	65372223	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:65372223G>A	ENST00000284037.5	+	24	4432	c.4043G>A	c.(4042-4044)aGa>aAa	p.R1348K	ERBB2IP_ENST00000380939.2_Missense_Mutation_p.R1296K|ERBB2IP_ENST00000416865.2_Missense_Mutation_p.R546K|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.R1307K|ERBB2IP_ENST00000503913.1_3'UTR|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.R1303K|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.R1355K|ERBB2IP_ENST00000380936.1_Intron|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.R1307K|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.R1238K|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.R1238K	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1348	PDZ.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AACCCATTCAGACCTGATGAT	0.338000													7	120					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106901	168106901	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:168106901C>G	ENST00000409195.1	+	9	9088	c.8999C>G	c.(8998-9000)gCc>gGc	p.A3000G	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.A2778G|XIRP2_ENST00000295237.9_Missense_Mutation_p.A3000G|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2825					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTCACATTGCCATGGAGAAT	0.333000													32	146					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568015	99568015	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:99568015G>A	ENST00000331335.5	-	5	2975	c.2505C>T	c.(2503-2505)gaC>gaT	p.D835D	FILIP1L_ENST00000471562.1_Silent_p.D595D|FILIP1L_ENST00000487087.1_Silent_p.D411D|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000354552.3_Silent_p.D835D|CMSS1_ENST00000496116.1_Intron|FILIP1L_ENST00000383694.2_Silent_p.D595D	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	835						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TAGGGTCCTCGTCTTGATTCT	0.458000													44	170					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13339193	13339193	+	RNA	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr4:13339193C>A	ENST00000602906.1	+	0	862																				kidney(3)|lung(1)	4						TCATCAGGGACAGCTGTGTTG	0.438000													5	52					3.59834e-05	4.07226e-05	1	1	0
TSIX	9383	broad.mit.edu	37	X	73046055	73046055	+	RNA	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chrX:73046055C>A	ENST00000604411.1	+	0	34016				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CATCTCTTCACATTTTTCTCT	0.438000													25	63					1.64293e-13	2.19058e-13	1	1	0
STON1	11037	broad.mit.edu	37	2	48809571	48809571	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:48809571G>C	ENST00000309835.3	+	1	1809	c.1799G>C	c.(1798-1800)cGa>cCa	p.R600P	STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.R600P|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.R600P|STON1_ENST00000406226.1_Missense_Mutation_p.R600P|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.R600P|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.R600P|STON1_ENST00000404752.1_Missense_Mutation_p.R600P|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.R600P					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATGAACCGCCGAGCATGTCTG	0.483000													19	105					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605973	142605973	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:142605973C>A	ENST00000265310.1	-	15	2245	c.1895_splice	c.e15-1	p.V633_splice		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	633					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TGGTTCTCAACCCTGATAAGG	0.507000													12	50					7.03913e-09	8.77999e-09	1	1	0
PLCXD3	345557	broad.mit.edu	37	5	41510621	41510621	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr5:41510621G>A	ENST00000377801.3	-	1	82	c.8C>T	c.(7-9)tCg>tTg	p.S3L	PLCXD3_ENST00000328457.3_Missense_Mutation_p.S3L			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	3					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						CCCCTGAGACGAGGCCATCGT	0.607000													4	44					0	0	1	0	0
KAT8	84148	broad.mit.edu	37	16	31142154	31142154	+	Silent	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:31142154C>A	ENST00000543774.2	+	11	1580	c.1245C>A	c.(1243-1245)atC>atA	p.I415I	KAT8_ENST00000448516.2_Silent_p.I415I|KAT8_ENST00000219797.4_Silent_p.I415I			Q9H7Z6	MYST1_HUMAN	K(lysine) acetyltransferase 8	415					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding										AGCACGTGATCTGTGTCACAC	0.542000													5	63					0.014758	0.0151498	1	1	0
C11orf82	220042	broad.mit.edu	37	11	82643386	82643386	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:82643386G>A	ENST00000533655.1	+	6	1218	c.1006G>A	c.(1006-1008)Gac>Aac	p.D336N	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000329143.3_Missense_Mutation_p.D35N|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000430323.2_Missense_Mutation_p.D336N	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	336					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TGGAGTTAATGACTCTAATTT	0.398000													13	146					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61951500	61951500	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr20:61951500C>T	ENST00000422202.1	+	23	3115	c.3047C>T	c.(3046-3048)aCg>aTg	p.T1016M	COL20A1_ENST00000358894.6_Missense_Mutation_p.T1009M|COL20A1_ENST00000326996.6_Missense_Mutation_p.T1009M|COL20A1_ENST00000435874.1_Missense_Mutation_p.T1016M			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1009	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GGCTTCGTCACGCTGGGGAGG	0.731000													3	8					0	0	1	0	0
H2AFX	3014	broad.mit.edu	37	11	118965881	118965881	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:118965881T>C	ENST00000530167.1	-	1	296	c.224A>G	c.(223-225)aAg>aGg	p.K75R		NM_002105.2	NP_002096.1	P16104	H2AX_HUMAN	H2A histone family, member X	75					DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding			lung(3)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		TCGCGTCTTCTTGTTGTCGCG	0.682000								Chromatin Structure			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	129					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48319222	48319222	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:48319222C>A	ENST00000435803.1	+	18	8455	c.8431C>A	c.(8431-8433)Caa>Aaa	p.Q2811K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2811					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AACTCATCATCAACTTGAAAA	0.333000													6	102					0.00116845	0.0012266	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11676358	11676358	+	Nonsense_Mutation	SNP	C	C	A	rs145194887	by1000genomes	TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:11676358C>A	ENST00000423059.3	-	2	672	c.421G>T	c.(421-423)Gag>Tag	p.E141*	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	141						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AGAGGTTTCTCTAGGCTTTTT	0.468000										HNSCC(18;0.044)			9	70					0.00448238	0.00464247	1	1	0
IFNG	3458	broad.mit.edu	37	12	68549256	68549256	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:68549256C>A	ENST00000229135.3	-	4	509	c.378G>T	c.(376-378)ttG>ttT	p.L126F	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	126					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	GTTGGACATTCAAGTCAGTTA	0.403000													24	48					0.00047179	0.000513874	1	1	0
KLF17	128209	broad.mit.edu	37	1	44595173	44595173	+	Missense_Mutation	SNP	C	C	T	rs144146386		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:44595173C>T	ENST00000372299.3	+	2	288	c.230C>T	c.(229-231)gCg>gTg	p.A77V	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	77					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCTGTTGAGGCGCCGGGGCAG	0.587000													10	86					0	0	1	0	0
ASGR2	433	broad.mit.edu	37	17	7010355	7010355	+	Missense_Mutation	SNP	G	G	T	rs139922820	byFrequency	TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:7010355G>T	ENST00000380952.2	-	7	891	c.627C>A	c.(625-627)aaC>aaA	p.N209K	ASGR2_ENST00000355035.5_Missense_Mutation_p.N209K|ASGR2_ENST00000446679.2_Missense_Mutation_p.N190K|ASGR2_ENST00000254850.7_Missense_Mutation_p.N185K	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	209	C-type lectin.				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	CCAGGTGTGCGTTCTCCAGCT	0.637000													12	98					4.93089e-13	6.49981e-13	1	1	0
ZNF536	9745	broad.mit.edu	37	19	31039929	31039929	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:31039929C>A	ENST00000355537.3	+	4	3550	c.3403C>A	c.(3403-3405)Cct>Act	p.P1135T		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CAACAAGGAGCCTGATGGAAA	0.527000													11	67					2.27111e-07	2.74426e-07	1	1	0
LRP2	4036	broad.mit.edu	37	2	170177288	170177288	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:170177288G>A	ENST00000263816.3	-	2	471	c.187_splice	c.e2+1	p.C62_splice	LRP2_ENST00000443831.1_Splice_Site_p.C62_splice	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	62	LDL-receptor class A 1.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTCACTTACCGCAGCCAATTT	0.488000													14	73					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105916637	105916637	+	Silent	SNP	G	G	A			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr14:105916637G>A	ENST00000331320.7	+	6	622	c.408G>A	c.(406-408)tcG>tcA	p.S136S	MTA1_ENST00000406191.1_Silent_p.S136S|MTA1_ENST00000405646.1_Silent_p.S119S	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	136	BAH.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		AGACCGAGTCGCTCAAGTCCT	0.682000													7	62					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103011082	103011082	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr2:103011082G>C	ENST00000409599.1	+	11	1621	c.1265G>C	c.(1264-1266)gGa>gCa	p.G422A	IL18R1_ENST00000233957.1_Missense_Mutation_p.G422A			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	422	TIR.				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GTAGTGCCTGGAGGAGGTAAG	0.403000													7	59					0	0	1	0	0
PMM2	5373	broad.mit.edu	37	16	8898643	8898643	+	Silent	SNP	T	T	C			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr16:8898643T>C	ENST00000268261.4	+	3	264	c.198T>C	c.(196-198)taT>taC	p.Y66Y	PMM2_ENST00000566983.1_Silent_p.Y39Y|PMM2_ENST00000539622.1_Intron|PMM2_ENST00000537352.1_Intron|PMM2_ENST00000569958.1_Intron	NM_000303.2	NP_000294.1	O15305	PMM2_HUMAN	phosphomannomutase 2	66					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			breast(3)|cervix(1)|endometrium(2)|large_intestine(1)|ovary(1)|skin(1)	9						AATACGATTATGTGTTTCCAG	0.333000													22	40					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68715370	68715370	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr12:68715370C>G	ENST00000303145.7	-	6	926	c.840G>C	c.(838-840)gaG>gaC	p.E280D	MDM1_ENST00000540418.1_5'UTR|MDM1_ENST00000411698.2_Missense_Mutation_p.E235D	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	280						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TTAATTCCATCTCTGCTTCCA	0.308000													11	34					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40712040	40712040	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr19:40712040G>T	ENST00000253055.3	+	5	1699	c.1411G>T	c.(1411-1413)Ggc>Tgc	p.G471C		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	471				G -> S (in Ref. 2; CAA88531).|LKLREGGSHISLPSGF -> AQAAGRRQPHQPALWL (in Ref. 3).	activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity	p.G471C(1)		NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GCGGGAAGGCGGCAGCCACAT	0.657000													5	29					0.0293803	0.0300275	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77616729	77616729	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr8:77616729G>T	ENST00000521891.2	+	2	854	c.406G>T	c.(406-408)Gat>Tat	p.D136Y	ZFHX4_ENST00000518282.1_Missense_Mutation_p.D136Y|ZFHX4_ENST00000455469.2_Missense_Mutation_p.D136Y|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D136Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	136						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTACCAGCCTGATGGGTCAGC	0.493000										HNSCC(33;0.089)			6	101					0.00116845	0.0012266	1	1	0
EPSTI1	94240	broad.mit.edu	37	13	43537455	43537455	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr13:43537455A>G	ENST00000313640.7	-	5	489	c.425T>C	c.(424-426)gTa>gCa	p.V142A	EPSTI1_ENST00000476830.2_5'UTR|EPSTI1_ENST00000398762.3_Missense_Mutation_p.V142A|EPSTI1_ENST00000313624.7_Missense_Mutation_p.V142A	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	142										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		CTTGATTCTTACAGATTCTTC	0.348000													18	62					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77757912	77757912	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr17:77757912G>T	ENST00000310942.4	+	5	774	c.670G>T	c.(670-672)Ggc>Tgc	p.G224C		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	224					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCCTGTGGCGGCCCCAGTGC	0.697000													8	46					0.000157383	0.000173871	1	1	0
RYR2	6262	broad.mit.edu	37	1	237919631	237919632	+	Frame_Shift_Ins	INS	-	-	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr1:237919631_237919632insT	ENST00000366574.2	+	81	11506_11507	c.11189_11190insT	c.(11188-11190)cctfs	p.P3730fs	RYR2_ENST00000360064.6_Frame_Shift_Ins_p.P3736fs|RYR2_ENST00000542537.1_Frame_Shift_Ins_p.P3714fs	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3730					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGCAAGCCCGACTCCACGATC	0.460													11	83	---	---	---	---					
DYNC1LI1	51143	broad.mit.edu	37	3	32576092	32576114	+	Frame_Shift_Del	DEL	TATATTTTTGTTTTCTTTTACTG	TATATTTTTGTTTTCTTTTACTG	-	rs150042247		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr3:32576092_32576114delTATATTTTTGTTTTCTTTTACTG	ENST00000273130.4	-	7	960_982	c.857_879delCAGTAAAAGAAAACAAAAATATA	c.(856-879)tfs	p.SVKENKNI286fs	DYNC1LI1_ENST00000432458.2_Frame_Shift_Del_p.SVKENKNI170fs	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	286					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity	p.E289*(1)		kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						ATACTAAGTCTATATTTTTGTTTTCTTTTACTGAAGTGTAAAT	0.305													9	93	---	---	---	---					
EIF3B	8662	broad.mit.edu	37	7	2395045	2395045	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:2395045delG	ENST00000360876.4	+	1	545	c.489delG	c.(487-489)gtfs	p.V163fs	EIF3B_ENST00000397011.2_Frame_Shift_Del_p.V163fs	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	163	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		TGGACGACGTGAGCGAGGAAG	0.731													2	4	---	---	---	---					
AUTS2	26053	broad.mit.edu	37	7	70255577	70255579	+	In_Frame_Del	DEL	CCA	CCA	-	rs35604576		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr7:70255577_70255579delCCA	ENST00000342771.4	+	19	3696_3698	c.3375_3377delCCA	c.(3373-3378)agc>ag	p.SH1125del	AUTS2_ENST00000406775.2_In_Frame_Del_p.SH1101del	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	1125	His-rich.									breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		ACGACTACAGccaccaccaccac	0.680													4	8	---	---	---	---					
MMP10	4319	broad.mit.edu	37	11	102650052	102650053	+	Frame_Shift_Ins	INS	-	-	T			TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr11:102650052_102650053insT	ENST00000279441.4	-	3	423_424	c.387_388insA	c.(385-390)gtattcfs	p.F130fs		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	130					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		ATGGCAGAATCAACAGCATCTC	0.401													7	246	---	---	---	---					
TPTEP1	387590	broad.mit.edu	37	22	17131536	17131537	+	RNA	INS	-	-	CTG	rs34452519		TCGA-NJ-A4YG-01A-22D-A25L-08	TCGA-NJ-A4YG-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9CE15B23-51AD-435A-9027-0E506747C78D	B1F07DC8-DE6E-40BA-B50C-2ADA419E3731	g.chr22:17131536_17131537insCTG	ENST00000426585.1	+	0	2562_2563																											TGCCCACTCTTCTGGTCTCATG	0.540													3	5	---	---	---	---					
