Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NHEJ1	79840	broad.mit.edu	37	2	220022292	220022292	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:220022292C>A	ENST00000356853.5	-	3	425	c.292G>T	c.(292-294)Gat>Tat	p.D98Y	NHEJ1_ENST00000409720.1_Missense_Mutation_p.D98Y	NM_024782.2	NP_079058.1	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	98					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	12		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		GCCACACAATCACAGGAGAAG	0.527000								Non-homologous end-joining					8	49					1.76689e-08	2.21011e-08	1	1	0
LRPPRC	10128	broad.mit.edu	37	2	44132909	44132909	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:44132909G>A	ENST00000260665.7	-	31	3343	c.3286C>T	c.(3286-3288)Cac>Tac	p.H1096Y		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	1096					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CCCTTGATGTGGGTCTCCGCG	0.423000													14	65					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55758925	55758925	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr20:55758925G>A	ENST00000395863.3	-	4	1316	c.811C>T	c.(811-813)Cag>Tag	p.Q271*	BMP7_ENST00000450594.2_Nonsense_Mutation_p.Q271*|BMP7_ENST00000460817.1_5'UTR|BMP7_ENST00000395864.3_Intron	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	271					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			TGCTTGTTCTGGGGCCCGTGC	0.622000													10	39					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215728	140215728	+	Missense_Mutation	SNP	C	C	G	rs139331486	byFrequency	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:140215728C>G	ENST00000525929.1	+	1	1760	c.1760C>G	c.(1759-1761)gCg>gGg	p.A587G	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.A587G|PCDHA1_ENST00000504120.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGTGGGCGCGGGCCATGTG	0.657000													24	101					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232649638	232649638	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:232649638C>A	ENST00000366630.1	-	2	1806	c.1448G>T	c.(1447-1449)gGg>gTg	p.G483V	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.G483V			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	483					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ATAATAGGCCCCAAGGTCAAT	0.463000													52	261					3.07002e-29	5.269e-29	1	1	0
TNR	7143	broad.mit.edu	37	1	175372482	175372482	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:175372482G>A	ENST00000367674.1	-	4	1478	c.770C>T	c.(769-771)aCt>aTt	p.T257I	TNR_ENST00000263525.2_Missense_Mutation_p.T257I	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	257	Cys-rich.|EGF-like 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GTCCTCGCCAGTGTAGGGCTC	0.622000													10	111					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134851891	134851891	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:134851891G>T	ENST00000398015.3	+	5	1667	c.1297_splice	c.e5+1	p.A433_splice	EPHB1_ENST00000493838.1_5'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	433	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						AAACCAAGCCGGTAAGTCTGG	0.567000													4	35					0.014758	0.0152969	1	1	0
SERPINA7	6906	broad.mit.edu	37	X	105278240	105278240	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:105278240G>T	ENST00000327674.4	-	3	1365	c.1030C>A	c.(1030-1032)Ctg>Atg	p.L344M	SERPINA7_ENST00000487487.1_5'UTR|SERPINA7_ENST00000372563.1_Missense_Mutation_p.L344M			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	344					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	GAAAGTTTCAGACCATTGTCC	0.368000													24	21					1.66031e-10	2.22783e-10	1	1	0
WNT3A	89780	broad.mit.edu	37	1	228210488	228210488	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:228210488C>A	ENST00000284523.1	+	2	270	c.192C>A	c.(190-192)ccC>ccA	p.P64P	WNT3A_ENST00000366753.2_Silent_p.P64P	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	64					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				AGATCATGCCCAGCGTGGCCG	0.647000													16	71					3.52763e-06	4.0678e-06	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77766583	77766583	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:77766583C>A	ENST00000521891.2	+	10	7874	c.7426C>A	c.(7426-7428)Caa>Aaa	p.Q2476K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q2450K|ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q2431K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q2431K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2431						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTCCACTGCAAATTTCCAT	0.527000										HNSCC(33;0.089)			11	64					5.50884e-06	6.31292e-06	1	1	0
GRM7	2917	broad.mit.edu	37	3	6903551	6903551	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:6903551G>T	ENST00000486284.1	+	1	750	c.476G>T	c.(475-477)aGt>aTt	p.S159I	GRM7_ENST00000403881.1_Missense_Mutation_p.S159I|GRM7_ENST00000389336.4_Missense_Mutation_p.S159I|GRM7_ENST00000357716.4_Missense_Mutation_p.S159I|GRM7_ENST00000402647.2_Missense_Mutation_p.S159I	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	159					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GCTTCGGGGAGTTCGGTCTCC	0.612000													13	67					6.31663e-08	7.69253e-08	1	1	0
HPDL	84842	broad.mit.edu	37	1	45793448	45793448	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:45793448G>A	ENST00000334815.3	+	1	904	c.628G>A	c.(628-630)Ggg>Agg	p.G210R		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	210					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					GTTTGGGCTTGGGGGACTGAG	0.637000													17	85					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121239565	121239565	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:121239565A>G	ENST00000297848.3	+	17	2381	c.2111A>G	c.(2110-2112)gAg>gGg	p.E704G	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.E609G|COL14A1_ENST00000309791.4_Missense_Mutation_p.E704G|COL14A1_ENST00000537875.1_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	704	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGCGAGAGTGAGGTGGTGACT	0.517000													23	88					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103270611	103270611	+	Silent	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:103270611T>C	ENST00000424685.2	-	20	2637	c.2478A>G	c.(2476-2478)gtA>gtG	p.V826V	RELN_ENST00000428762.1_Silent_p.V826V|RELN_ENST00000343529.5_Silent_p.V826V			P78509	RELN_HUMAN	reelin	826					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGGTAGTTCTACGGAGATTA	0.343000													20	84					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038944	11038944	+	RNA	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr21:11038944A>T	ENST00000470054.1	-	0	1259									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGTCTGCTGATAATGAAAAT	0.418000													40	847					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220652	1220652	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:1220652A>G	ENST00000326873.7	+	5	1843	c.670A>G	c.(670-672)Att>Gtt	p.I224V		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	224	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCCCGAGATTGCCAACGG	0.706000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			14	14					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228487609	228487609	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:228487609A>T	ENST00000570156.2	+	51	13575	c.13501A>T	c.(13501-13503)Atg>Ttg	p.M4501L	OBSCN_ENST00000366707.4_Missense_Mutation_p.M1191L|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000602685.1_3'UTR|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000422127.1_Intron|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000359599.6_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3544	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CATAGAGGATATGAGAAACCA	0.512000													16	149					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122283098	122283098	+	Translation_Start_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:122283098G>T	ENST00000462315.1	-	0	64				DTX3L_ENST00000296161.4_5'UTR|PARP9_ENST00000360356.2_Intron|PARP9_ENST00000477522.2_Intron|PARP9_ENST00000492382.1_De_novo_Start_OutOfFrame	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9						cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		TCACCCGGCAGGCCGCTCTCC	0.711000													3	1					1	1	1	1	0
ZNF649	65251	broad.mit.edu	37	19	52394964	52394964	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:52394964T>A	ENST00000354957.3	-	5	709	c.425A>T	c.(424-426)aAt>aTt	p.N142I	ZNF649_ENST00000600738.1_Missense_Mutation_p.N142I|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TTGTTCATGATTATCATGGAG	0.383000													44	205					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104244	142104244	+	RNA	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:142104244G>T	ENST00000390379.1	-	0	220																											TCCTTTGTCAGTGATACCAGC	0.522000													59	197					2.40265e-35	4.242e-35	1	1	0
TTN	7273	broad.mit.edu	37	2	179600298	179600298	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:179600298C>A	ENST00000589042.1	-	50	15099	c.14875G>T	c.(14875-14877)Gtc>Ttc	p.V4959F	TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V4642F|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.V3715F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4642	Ig-like 30.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTACAGACATAGGTTCCT	0.433000													7	39					5.18039e-06	5.95503e-06	1	1	0
COX6C	1345	broad.mit.edu	37	8	100904277	100904277	+	Splice_Site	SNP	T	T	C	rs1130474	by1000genomes	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:100904277T>C	ENST00000297564.2	-	2	46		c.e2-2		COX6C_ENST00000522940.1_5'UTR|COX6C_ENST00000523016.1_5'UTR|COX6C_ENST00000518171.1_5'UTR|COX6C_ENST00000524245.1_5'UTR|COX6C_ENST00000520271.1_5'UTR|COX6C_ENST00000520468.2_5'UTR|COX6C_ENST00000517682.2_Splice_Site			P09669	COX6C_HUMAN	cytochrome c oxidase subunit VIc						respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity		HMGA2/COX6C(2)	liver(1)|lung(2)	3			all cancers(13;8.32e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATACGTAtgctaaccttaaga	0.453000			T	HMGA2	uterine leiomyoma								7	73					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8139506	8139506	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:8139506T>A	ENST00000315684.8	-	6	954	c.947A>T	c.(946-948)cAg>cTg	p.Q316L		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	316					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TTCCAGCTCCTGCACACATTC	0.562000													38	76					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97544653	97544653	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:97544653C>G	ENST00000370192.3	-	23	3057	c.2957G>C	c.(2956-2958)tGt>tCt	p.C986S		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	986	4Fe-4S ferredoxin-type 3.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACAGCCTGTACAAGTGTCGGT	0.458000													24	176					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72832261	72832261	+	Silent	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:72832261A>T	ENST00000268489.5	-	9	4992	c.4320T>A	c.(4318-4320)acT>acA	p.T1440T	ZFHX3_ENST00000397992.5_Silent_p.T526T	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1440					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GAGCCTGGAAAGTTCGGAAAC	0.537000													17	154					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27745469	27745469	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:27745469G>A	ENST00000430629.2	-	3	466	c.251C>T	c.(250-252)cCc>cTc	p.P84L	WASF2_ENST00000536657.1_Missense_Mutation_p.P84L	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	84					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TTCTTCCTTGGGATCCAGCTG	0.428000													23	78					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167249008	167249008	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:167249008C>A	ENST00000308378.3	-	9	1362	c.1057G>T	c.(1057-1059)Gac>Tac	p.D353Y	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Missense_Mutation_p.D417Y|WDR49_ENST00000476376.1_Missense_Mutation_p.D178Y	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	353								p.D353H(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						GTAGAATGGTCTGCCATGGGG	0.433000													15	77					4.7546e-09	6.02903e-09	1	1	0
DIRAS3	9077	broad.mit.edu	37	1	68512912	68512912	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:68512912C>A	ENST00000370981.1	-	4	705	c.69G>T	c.(67-69)ctG>ctT	p.L23L	DIRAS3_ENST00000395201.1_Silent_p.L23L|GNG12-AS1_ENST00000420587.1_RNA|GNG12-AS1_ENST00000413628.1_RNA			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	23					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GGAGGATAAGCAGGGCGGGCA	0.587000													16	73					6.31663e-08	7.69253e-08	1	1	0
THBS4	7060	broad.mit.edu	37	5	79355604	79355604	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:79355604G>A	ENST00000350881.2	+	7	1053	c.863G>A	c.(862-864)cGt>cAt	p.R288H	THBS4_ENST00000511733.1_Missense_Mutation_p.R197H|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	288	EGF-like 1.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CGCCCACCTCGTCGGTGTGAC	0.602000													17	232					0	0	1	0	0
PPBP	5473	broad.mit.edu	37	4	74853311	74853311	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:74853311G>A	ENST00000296028.3	-	2	300	c.207C>T	c.(205-207)acC>acT	p.T69T		NM_002704.3	NP_002695.1	P02775	CXCL7_HUMAN	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	69					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			breast(1)|central_nervous_system(1)|lung(1)|ovary(2)|skin(2)|stomach(1)|urinary_tract(2)	10	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GAATTCCAGAGGTTGTCTTTA	0.413000													22	95					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56458992	56458992	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:56458992C>A	ENST00000370754.5	-	48	12102		c.e48-1		DST_ENST00000312431.6_Splice_Site|DST_ENST00000370788.2_Splice_Site|DST_ENST00000446842.2_Splice_Site|DST_ENST00000361203.3_Splice_Site|DST_ENST00000370769.4_Splice_Site|DST_ENST00000421834.2_Splice_Site|DST_ENST00000244364.6_Splice_Site			Q03001	DYST_HUMAN	dystonin						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGTGTTGGGCCTATGTGAAAA	0.473000													42	179					8.04919e-23	1.30844e-22	1	1	0
ITGAX	3687	broad.mit.edu	37	16	31374284	31374284	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:31374284G>T	ENST00000268296.4	+	13	1509	c.1388G>T	c.(1387-1389)tGc>tTc	p.C463F	ITGAX_ENST00000562522.1_Missense_Mutation_p.C463F	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	463					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GCCTCCCTCTGCTCCGTGGAC	0.672000													37	98					1.49673e-21	2.36023e-21	1	1	0
SHROOM4	57477	broad.mit.edu	37	X	50376865	50376865	+	Silent	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:50376865T>C	ENST00000376020.2	-	4	2233	c.2208A>G	c.(2206-2208)ccA>ccG	p.P736P	SHROOM4_ENST00000289292.7_Silent_p.P736P|SHROOM4_ENST00000460112.3_Silent_p.P620P	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	736					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTGCCACAAGTGGCTGTGAAT	0.542000													16	27					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	271189	271189	+	Silent	SNP	G	G	T	rs138827697	byFrequency	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:271189G>T	ENST00000538872.1	+	8	2659	c.2541G>T	c.(2539-2541)acG>acT	p.T847T	IQSEC3_ENST00000326261.4_Silent_p.T847T|IQSEC3_ENST00000382841.2_Silent_p.T544T			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	847					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		ACCACGTCACGTACGTCACCA	0.532000													8	33					5.4927e-09	6.94112e-09	1	1	0
SEL1L	6400	broad.mit.edu	37	14	81972490	81972490	+	Silent	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:81972490T>G	ENST00000336735.4	-	4	552	c.436A>C	c.(436-438)Agg>Cgg	p.R146R	SEL1L_ENST00000555824.1_Silent_p.R146R	NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	146	Fibronectin type-II.|Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		CCATCTTCCCTCCCATCTGAT	0.473000													54	174					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51738461	51738461	+	Silent	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:51738461T>A	ENST00000436584.2	+	4	469	c.414T>A	c.(412-414)gcT>gcA	p.A138A	CD33_ENST00000421133.2_Silent_p.A138A|CD33_ENST00000262262.4_Silent_p.A265A|CD33_ENST00000391796.3_Silent_p.A265A			P20138	CD33_HUMAN	CD33 molecule	265					cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TTGGAGGAGCTGGTGTTACAG	0.498000													14	68					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212652753	212652753	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:212652753C>A	ENST00000342788.4	-	4	863	c.553G>T	c.(553-555)Gga>Tga	p.G185*	ERBB4_ENST00000402597.1_Nonsense_Mutation_p.G185*|ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000436443.1_Nonsense_Mutation_p.G185*	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	185					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TACTTACATCCTGAACTACCA	0.343000										TSP Lung(8;0.080)			16	62					6.31663e-08	7.69253e-08	1	1	0
SOHLH1	402381	broad.mit.edu	37	9	138588636	138588636	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:138588636C>T	ENST00000298466.5	-	5	543	c.483G>A	c.(481-483)aaG>aaA	p.K161K	SOHLH1_ENST00000425225.1_Silent_p.K161K	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	161					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CCAGAAACGCCTTCACATCTG	0.637000													17	48					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56297072	56297072	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:56297072A>G	ENST00000443188.1	-	12	3731	c.3021T>C	c.(3019-3021)aaT>aaC	p.N1007N	NLRP11_ENST00000360133.3_Silent_p.N953N|NLRP11_ENST00000592953.1_Silent_p.N908N|NLRP11_ENST00000589824.2_Silent_p.N953N|NLRP11_ENST00000589093.1_Silent_p.N1007N	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	1007							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGTAATCCAAATTAGAATTAG	0.398000													38	88					0	0	1	0	0
PSMB11	122706	broad.mit.edu	37	14	23512245	23512245	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:23512245C>T	ENST00000408907.2	+	1	870	c.811C>T	c.(811-813)Cac>Tac	p.H271Y		NM_001099780.1	NP_001093250.1	A5LHX3	PSB11_HUMAN	proteasome (prosome, macropain) subunit, beta type, 11	271					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|kidney(2)|lung(4)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TGCCACTGCCCACAGAGCTGC	0.612000													6	29					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36700232	36700232	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr13:36700232G>T	ENST00000255448.4	-	2	254	c.43C>A	c.(43-45)Cgg>Agg	p.R15R	DCLK1_ENST00000379892.4_Silent_p.R15R|DCLK1_ENST00000360631.3_Silent_p.R15R	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	15					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCCTTATCCCGCTCGTCGAAG	0.597000													11	92					4.3838e-07	5.20136e-07	1	1	0
ANK1	286	broad.mit.edu	37	8	41551585	41551585	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:41551585G>T	ENST00000396942.1	-	29	3446	c.3363C>A	c.(3361-3363)ctC>ctA	p.L1121L	ANK1_ENST00000265709.8_Silent_p.L1162L|ANK1_ENST00000352337.4_Silent_p.L1121L|ANK1_ENST00000396945.1_Silent_p.L1121L|ANK1_ENST00000289734.7_Silent_p.L1121L|ANK1_ENST00000347528.4_Silent_p.L1121L|ANK1_ENST00000379758.2_Silent_p.L1121L			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1121					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGTTGCCCAGGAGCTTAGTGA	0.622000													7	37					1.26484e-09	1.66095e-09	1	1	0
AASS	10157	broad.mit.edu	37	7	121757012	121757012	+	Splice_Site	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:121757012C>T	ENST00000393376.1	-	6	783		c.e6-1		AASS_ENST00000417368.2_Splice_Site|AASS_ENST00000473553.1_Intron			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase						protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTTGGGCTCCCTACAAATAAC	0.378000													7	121					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182408	140182408	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:140182408G>A	ENST00000522353.2	+	1	1626	c.1626G>A	c.(1624-1626)gtG>gtA	p.V542V	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Silent_p.V542V|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCGGGCGTGCCGCCTCTGG	0.682000													39	153					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370440	126370440	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:126370440G>T	ENST00000394329.3	+	9	8282	c.8269G>T	c.(8269-8271)Gta>Tta	p.V2757L	FAT4_ENST00000335110.5_Missense_Mutation_p.V1055L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2757	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGTACTTCAGTAAAAGTCAT	0.378000													31	147					4.06085e-26	6.81115e-26	1	1	0
ART5	116969	broad.mit.edu	37	11	3660972	3660972	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:3660972G>T	ENST00000397068.3	-	2	1079	c.687C>A	c.(685-687)gtC>gtA	p.V229V	ART5_ENST00000359918.4_Silent_p.V229V|ART5_ENST00000397067.3_Intron	NM_053017.3	NP_443750.2	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	229						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAACCAAAAAGACTTCATGGG	0.517000													31	134					1.56442e-22	2.53189e-22	1	1	0
HSPA4L	22824	broad.mit.edu	37	4	128719837	128719837	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:128719837G>A	ENST00000296464.3	+	4	813	c.402G>A	c.(400-402)aaG>aaA	p.K134K	HSPA4L_ENST00000508776.1_Silent_p.K134K|HSPA4L_ENST00000505726.1_Silent_p.K108K|HSPA4L_ENST00000439123.2_Silent_p.K165K	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	134					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						ATGCTTTGAAGAAACCAGTGG	0.348000													17	72					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40661982	40661982	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr22:40661982G>T	ENST00000454349.2	+	5	1959	c.1748G>T	c.(1747-1749)aGt>aTt	p.S583I	TNRC6B_ENST00000335727.8_Missense_Mutation_p.S583I|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000402203.1_Intron	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	583					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GCAGGAAGTAGTGACAGTCAT	0.537000													17	107					3.41278e-10	4.52992e-10	1	1	0
AGBL1	123624	broad.mit.edu	37	15	86822927	86822927	+	Nonsense_Mutation	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:86822927T>G	ENST00000441037.2	+	15	2090	c.1995T>G	c.(1993-1995)taT>taG	p.Y665*	AGBL1_ENST00000421325.2_Nonsense_Mutation_p.Y665*|AGBL1_ENST00000389298.3_Nonsense_Mutation_p.Y396*	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	665					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						AGTGCTACTATACCCTCACCT	0.498000													56	106					0	0	1	0	0
FAM220A	84792	broad.mit.edu	37	7	6370132	6370132	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:6370132G>A	ENST00000313324.4	-	2	1121	c.654C>T	c.(652-654)ccC>ccT	p.P218P		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	218						nucleus											TTGAAAACATGGGCTTTAAAC	0.463000													32	155					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31390237	31390237	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr20:31390237G>C	ENST00000328111.2	+	20	2513	c.2192G>C	c.(2191-2193)aGg>aCg	p.R731T	DNMT3B_ENST00000348286.2_Missense_Mutation_p.R711T|DNMT3B_ENST00000353855.2_Missense_Mutation_p.R711T|DNMT3B_ENST00000443239.3_Missense_Mutation_p.R669T|DNMT3B_ENST00000201963.3_Missense_Mutation_p.R723T|DNMT3B_ENST00000344505.4_Missense_Mutation_p.R711T|DNMT3B_ENST00000456297.2_Missense_Mutation_p.R635T	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	731					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCTGCTCACAGGGCCCGATAC	0.458000													23	152					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741263	140741263	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:140741263G>A	ENST00000522605.1	+	1	1561	c.1561G>A	c.(1561-1563)Gat>Aat	p.D521N	PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCCTTCGATCATGAGCA	0.662000													17	66					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2807886	2807886	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:2807886A>T	ENST00000301740.8	+	4	1004	c.455A>T	c.(454-456)gAt>gTt	p.D152V		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	152						Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						agctcttttGATCCTCAGCGT	0.478000													18	127					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290695	15290695	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:15290695G>T	ENST00000378116.4	-	5	703	c.697C>A	c.(697-699)Cag>Aag	p.Q233K	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	233						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						AGGCTGCTCTGCGTGGCCAGG	0.597000													31	55					2.85442e-18	4.26429e-18	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25321113	25321113	+	RNA	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:25321113A>T	ENST00000549804.2	+	0	1109				SNORD116-11_ENST00000383882.1_RNA																							TTCCTTGGAAAGTTGAACAAA	0.438000													21	72					0	0	1	0	0
SMAD1	4086	broad.mit.edu	37	4	146475128	146475128	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:146475128A>G	ENST00000515385.1	+	6	1732	c.1190A>G	c.(1189-1191)aAc>aGc	p.N397S	SMAD1_ENST00000394092.2_Missense_Mutation_p.N397S|SMAD1_ENST00000302085.4_Missense_Mutation_p.N397S			Q15797	SMAD1_HUMAN	SMAD family member 1	397	MH2.				BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	17	all_hematologic(180;0.151)					CAGTCTGTGAACCATGGATTT	0.408000													22	147					0	0	1	0	0
TBL1X	6907	broad.mit.edu	37	X	9622317	9622317	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:9622317A>T	ENST00000217964.7	+	5	806	c.166A>T	c.(166-168)Agt>Tgt	p.S56C	TBL1X_ENST00000536365.1_Missense_Mutation_p.S5C|TBL1X_ENST00000380961.1_Missense_Mutation_p.S5C|TBL1X_ENST00000407597.2_Missense_Mutation_p.S56C|TBL1X_ENST00000424279.1_Missense_Mutation_p.S5C	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	56	LisH.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				GAGCATAACCAGTGACGAGGT	0.468000													26	33					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597576	247597576	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:247597576G>T	ENST00000366497.2	+	6	3278		c.e6+1		NLRP3_ENST00000348069.2_Splice_Site|NLRP3_ENST00000366496.2_Splice_Site|NLRP3_ENST00000391828.3_Splice_Site|NLRP3_ENST00000336119.3_Splice_Site|NLRP3_ENST00000391827.2_Splice_Site	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3						detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGAAGCTCTGGTGAGTCGAGC	0.587000													32	88					6.70999e-13	9.48653e-13	1	1	0
LINC00691	152024	broad.mit.edu	37	3	24138535	24138535	+	RNA	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:24138535G>T	ENST00000436123.1	-	0	2188																											ATATGCATTGGCCTTGATCCA	0.453000													3	19					0.115264	0.118475	1	1	0
PHF20	51230	broad.mit.edu	37	20	34435328	34435328	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr20:34435328G>T	ENST00000374012.3	+	4	441	c.312G>T	c.(310-312)ccG>ccT	p.P104P	PHF20_ENST00000439301.1_Silent_p.P104P|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GTTTTTACCCGGCCAAAGTCA	0.383000													10	70					0.000673444	0.000728741	1	1	0
DHX29	54505	broad.mit.edu	37	5	54557319	54557319	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:54557319A>G	ENST00000251636.5	-	25	3985	c.3837T>C	c.(3835-3837)taT>taC	p.Y1279Y	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1279							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ACACTCTGGCATACCTTATCT	0.343000													35	104					0	0	1	0	0
CEP55	55165	broad.mit.edu	37	10	95279445	95279445	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:95279445G>A	ENST00000371485.3	+	8	1376	c.1072G>A	c.(1072-1074)Gca>Aca	p.A358T	CEP55_ENST00000496302.1_3'UTR	NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	358	Required for localization to the interphase centrosome and to the midbody during cytokinesis.				cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				CCAGATGCAGGCATGTACTTT	0.388000													26	74					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269424	150269424	+	Missense_Mutation	SNP	T	T	A	rs150127804		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:150269424T>A	ENST00000255945.2	+	3	441	c.266T>A	c.(265-267)aTt>aAt	p.I89N	GIMAP4_ENST00000461940.1_Missense_Mutation_p.I103N|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	89							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACACCAGGCATTTTCGACACA	0.493000													15	49					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30937203	30937203	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:30937203T>A	ENST00000597505.1	-	25	3507	c.3508A>T	c.(3508-3510)Aga>Tga	p.R1170*	DCDC1_ENST00000339794.5_Nonsense_Mutation_p.R249*|DCDC1_ENST00000406071.2_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGCCCATCTCTGTATTCGAAC	0.453000													8	64					0	0	1	0	0
LRRC59	55379	broad.mit.edu	37	17	48465443	48465443	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:48465443C>G	ENST00000225972.7	-	5	715	c.480G>C	c.(478-480)caG>caC	p.Q160H		NM_018509.3	NP_060979.2	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	160						endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CCAGCCGCCGCTGCCTCTCCC	0.532000													33	125					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79350029	79350029	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:79350029C>A	ENST00000233735.1	+	5	487	c.384C>A	c.(382-384)gcC>gcA	p.A128A		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	128	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCATTGGAGCCCCAAGCAGTG	0.572000													20	102					1.33834e-09	1.73279e-09	1	1	0
RYR2	6262	broad.mit.edu	37	1	237823308	237823308	+	Silent	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:237823308A>T	ENST00000366574.2	+	55	8549	c.8232A>T	c.(8230-8232)ggA>ggT	p.G2744G	RYR2_ENST00000360064.6_Silent_p.G2742G|RYR2_ENST00000542537.1_Silent_p.G2728G	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2744	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGATTTATGGAGAAATATATT	0.299000													4	29					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73994861	73994861	+	Silent	SNP	G	G	T	rs145054349	byFrequency	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:73994861G>T	ENST00000318443.5	+	3	647	c.345G>T	c.(343-345)gcG>gcT	p.A115A	CD276_ENST00000561213.1_Silent_p.A115A|CD276_ENST00000537340.2_5'UTR|CD276_ENST00000564751.1_Silent_p.A115A|CD276_ENST00000318424.5_Silent_p.A115A	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	115	Ig-like V-type 1.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						TGCGTGTGGCGGACGAGGGCA	0.697000													9	23					0.000274275	0.000301213	1	1	0
SPNS3	201305	broad.mit.edu	37	17	4352625	4352625	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:4352625G>A	ENST00000355530.2	+	7	1146	c.866G>A	c.(865-867)cGc>cAc	p.R289H	SPNS3_ENST00000333476.2_Missense_Mutation_p.R162H|SPNS3_ENST00000576069.1_Intron	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	289					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						CTCGAGGCACGCGTGGTTCAC	0.687000													8	83					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76803619	76803619	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:76803619G>T	ENST00000338487.5	-	2	356	c.357C>A	c.(355-357)ttC>ttA	p.F119L		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	119	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.F119F(1)		breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CACTGAGGTCGAAGGTGGGCA	0.677000													6	105					0.00198382	0.00212182	1	1	0
FRMD4A	55691	broad.mit.edu	37	10	13852880	13852880	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:13852880T>G	ENST00000357447.2	-	4	508	c.140A>C	c.(139-141)gAc>gCc	p.D47A	FRMD4A_ENST00000378503.1_Missense_Mutation_p.D47A|FRMD4A_ENST00000358621.4_Missense_Mutation_p.D32A|FRMD4A_ENST00000342409.2_Missense_Mutation_p.D63A	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	47	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						AGCCACAAGGTCAAGAAGCTC	0.453000													11	39					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134851892	134851892	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:134851892G>T	ENST00000398015.3	+	5	1667		c.e5+1		EPHB1_ENST00000493838.1_Splice_Site	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1							integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.?(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						AACCAAGCCGGTAAGTCTGGA	0.567000													4	34					0.014758	0.0152969	1	1	0
KRT39	390792	broad.mit.edu	37	17	39119985	39119985	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:39119985C>T	ENST00000355612.2	-	3	637	c.602G>A	c.(601-603)gGc>gAc	p.G201D	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	201	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				CTGCTTGAGGCCATTGGCATC	0.502000													32	90					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153910335	153910335	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:153910335T>A	ENST00000361217.4	-	14	2388	c.1970A>T	c.(1969-1971)cAc>cTc	p.H657L		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	657										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGCTCTGGGTGGACCTGGAG	0.557000													30	122					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461439	76461439	+	Missense_Mutation	SNP	G	G	A	rs143711679	byFrequency	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:76461439G>A	ENST00000307431.8	+	5	863	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.E160K|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.E136K|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.E164K	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	161	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CATCCCTTTGGAATGGAACCC	0.408000													43	129					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14752854	14752854	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:14752854G>A	ENST00000358984.4	+	3	533	c.353G>A	c.(352-354)aGg>aAg	p.R118K	ANKRD30B_ENST00000447268.2_Missense_Mutation_p.R118K|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	118										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						CAATGCGAGAGGGAGGCTTGT	0.363000													6	37					0	0	1	0	0
PEX26	55670	broad.mit.edu	37	22	18567976	18567976	+	Missense_Mutation	SNP	C	C	T	rs149976406		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr22:18567976C>T	ENST00000329627.6	+	5	972	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	PEX26_ENST00000399744.3_Missense_Mutation_p.L256F|PEX26_ENST00000428061.2_Intron	NM_017929.5	NP_060399.1	Q7Z412	PEX26_HUMAN	peroxisomal biogenesis factor 26	256					protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding	p.L256V(1)		breast(1)|kidney(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						CAAAAAGAGTCTCCTGGCTGC	0.547000													7	71					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200290	123200290	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:123200290G>T	ENST00000528880.2	-	1	1149	c.995C>A	c.(994-996)aCa>aAa	p.T332K	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	332						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	GGGGTCCCCTGTGAGCTCGAC	0.547000													37	82					7.53189e-24	1.24631e-23	1	1	0
OR4D11	219986	broad.mit.edu	37	11	59271549	59271549	+	Silent	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:59271549T>A	ENST00000313253.1	+	1	501	c.501T>A	c.(499-501)ccT>ccA	p.P167P		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TGCCTCTCCCTTTCTGTGGAC	0.512000													39	224					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271597	59271597	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:59271597G>T	ENST00000313253.1	+	1	549	c.549G>T	c.(547-549)caG>caT	p.Q183H		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						ATGTCCCCCAGGTCCTCAAAC	0.502000													91	200					3.07327e-39	5.47844e-39	1	1	0
FAP	2191	broad.mit.edu	37	2	163027562	163027562	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:163027562G>T	ENST00000188790.4	-	26	2417	c.2210C>A	c.(2209-2211)tCc>tAc	p.S737Y	AC007750.5_ENST00000418968.2_RNA|FAP_ENST00000443424.1_Missense_Mutation_p.S712Y	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	737					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GGACAGGCCGGATAAGCCGTG	0.433000													42	105					6.07928e-31	1.05814e-30	1	1	0
DPP4	1803	broad.mit.edu	37	2	162873317	162873317	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:162873317G>A	ENST00000360534.3	-	18	2088	c.1528C>T	c.(1528-1530)Ccc>Tcc	p.P510S	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	510					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TTTTTGGAGGGCATCTGGACA	0.373000													19	79					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31414949	31414949	+	Silent	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:31414949G>C	ENST00000389202.2	+	7	736	c.687G>C	c.(685-687)acG>acC	p.T229T	RP11-120K18.2_ENST00000567545.1_RNA	NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	229	VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCACGGCCACGGGCATCCTGA	0.607000													26	86					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793096	143793096	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:143793096C>A	ENST00000408949.2	+	1	956	c.896C>A	c.(895-897)gCt>gAt	p.A299D		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					GTGAAAGGGGCTCTAAAGAGA	0.453000													83	237					1.32003e-40	2.36453e-40	1	1	0
FAM71A	149647	broad.mit.edu	37	1	212798781	212798781	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:212798781C>A	ENST00000294829.3	+	1	993	c.562C>A	c.(562-564)Cca>Aca	p.P188T	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	188										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CTGTGGCATTCCAGCTGAAGA	0.527000													53	226					6.60958e-23	1.08397e-22	1	1	0
HGF	3082	broad.mit.edu	37	7	81355323	81355323	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:81355323C>A	ENST00000222390.5	-	9	1277	c.1051G>T	c.(1051-1053)Gaa>Taa	p.E351*	HGF_ENST00000457544.2_Nonsense_Mutation_p.E346*	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	351	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CAGTAATTTTCTCGTAGGTCC	0.413000													32	92					2.85442e-18	4.26429e-18	1	1	0
NGLY1	55768	broad.mit.edu	37	3	25792606	25792606	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:25792606G>C	ENST00000428257.1	-	4	748	c.641C>G	c.(640-642)gCt>gGt	p.A214G	NGLY1_ENST00000417874.2_Missense_Mutation_p.A172G|NGLY1_ENST00000422724.2_Missense_Mutation_p.A137G|NGLY1_ENST00000280700.5_Missense_Mutation_p.A214G|NGLY1_ENST00000396649.3_Missense_Mutation_p.A214G	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	214					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						CAATTTTCTAGCTCTCGATAA	0.348000													7	31					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	424204	424204	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:424204G>T	ENST00000256509.2	+	18	2668	c.2026G>T	c.(2026-2028)Gag>Tag	p.E676*	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Nonsense_Mutation_p.E660*	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	660	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGGAAGGTGGGAGGAACTGAC	0.403000													15	118					4.7546e-09	6.02903e-09	1	1	0
OR2C3	81472	broad.mit.edu	37	1	247694974	247694974	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:247694974G>T	ENST00000366487.3	-	2	1201	c.840C>A	c.(838-840)acC>acA	p.T280T	GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000366489.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T279T(1)		breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GAGTGACTACGGTGTAGAACA	0.532000													12	138					0.010729	0.0112472	1	1	0
SNX20	124460	broad.mit.edu	37	16	50707434	50707434	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:50707434G>A	ENST00000330943.4	-	4	1005	c.834C>T	c.(832-834)taC>taT	p.Y278Y	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	278					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						TGCCCAGCGCGTAGGCCAGGC	0.697000													23	46					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87017926	87017926	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:87017926C>A	ENST00000398399.2	-	3	1114	c.751G>T	c.(751-753)Gct>Tct	p.A251S	VGLL3_ENST00000383698.3_Missense_Mutation_p.A251S	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCAGAGCCAGCAGGAGggtgg	0.587000													11	55					3.07112e-06	3.56365e-06	1	1	0
USP26	83844	broad.mit.edu	37	X	132159518	132159518	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:132159518G>T	ENST00000511190.1	-	6	3200	c.2731C>A	c.(2731-2733)Cag>Aag	p.Q911K	USP26_ENST00000370832.1_Missense_Mutation_p.Q911K|USP26_ENST00000406273.1_Missense_Mutation_p.Q911K	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	911					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					TATTCCTTCTGAAGGGTCTCC	0.428000													27	22					4.22769e-11	5.77785e-11	1	1	0
MYF6	4618	broad.mit.edu	37	12	81101501	81101501	+	Translation_Start_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:81101501G>T	ENST00000228641.3	+	1	225	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	1					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						AGGAGAACATGATGATGGACC	0.453000													24	95					4.26978e-12	5.96798e-12	1	1	0
KCNK13	56659	broad.mit.edu	37	14	90650454	90650454	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:90650454G>A	ENST00000282146.4	+	2	775		c.e2-1			NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13							integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CTCTCCTGCAGGGTTTGGGAT	0.458000													23	97					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127664342	127664342	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:127664342T>C	ENST00000508989.1	-	33	4635	c.4418A>G	c.(4417-4419)cAg>cGg	p.Q1473R	FBN2_ENST00000508053.1_Intron|FBN2_ENST00000262464.4_Intron|FBN2_ENST00000507835.1_Missense_Mutation_p.Q356R			P35556	FBN2_HUMAN	fibrillin 2	0	EGF-like 24; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTCATTTACTGTGGTTGATC	0.478000													5	29					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166904536	166904536	+	Splice_Site	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:166904536A>G	ENST00000271417.3	-	6	936		c.e6+1		ILDR2_ENST00000469934.2_Splice_Site|ILDR2_ENST00000526687.1_Intron|ILDR2_ENST00000529071.1_Splice_Site|ILDR2_ENST00000528703.1_Intron|ILDR2_ENST00000525740.1_Intron|ILDR2_ENST00000529387.1_Intron	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2							integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						AACTACATTTACCACTGTGGC	0.542000													41	98					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114290868	114290868	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:114290868C>A	ENST00000357077.4	+	43	11570	c.11517C>A	c.(11515-11517)agC>agA	p.S3839R	ANK2_ENST00000506722.1_Missense_Mutation_p.S1745R|ANK2_ENST00000264366.6_Missense_Mutation_p.S3806R|ANK2_ENST00000509550.1_Missense_Mutation_p.S930R|ANK2_ENST00000510275.2_Missense_Mutation_p.S406R|ANK2_ENST00000394537.3_Missense_Mutation_p.S1754R	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3806					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGAGGAGAGCTCTCCGCGGA	0.542000													24	76					2.21704e-12	3.12247e-12	1	1	0
NAV2	89797	broad.mit.edu	37	11	20075694	20075694	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:20075694G>T	ENST00000396085.1	+	18	4911	c.4550G>T	c.(4549-4551)gGa>gTa	p.G1517V	NAV2_ENST00000533917.1_Missense_Mutation_p.G581V|NAV2_ENST00000540292.1_Missense_Mutation_p.G1471V|NAV2_ENST00000360655.4_Missense_Mutation_p.G1453V|NAV2_ENST00000349880.4_Missense_Mutation_p.G1517V|NAV2_ENST00000311043.8_Missense_Mutation_p.G581V|NAV2_ENST00000396087.3_Missense_Mutation_p.G1540V|NAV2_ENST00000527559.2_Missense_Mutation_p.G1469V	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1540	Ser-rich.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CATTCTGCAGGAGGCCTTCAG	0.522000													12	37					0.0135373	0.0141509	1	1	0
GRK7	131890	broad.mit.edu	37	3	141497490	141497490	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:141497490C>A	ENST00000264952.2	+	1	501	c.364C>A	c.(364-366)Ccg>Acg	p.P122T		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	122	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCCGGGGAACCCGCAACCCTT	0.677000													17	44					1.5739e-10	2.11959e-10	1	1	0
KAZN	23254	broad.mit.edu	37	1	15440972	15440972	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:15440972C>A	ENST00000376030.2	+	15	2463	c.2169C>A	c.(2167-2169)ccC>ccA	p.P723P		NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	723					keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						CTCAGCTGCCCCTGGGGAAGA	0.453000													4	15					3.59834e-05	4.03582e-05	1	1	0
DVL3	1857	broad.mit.edu	37	3	183884013	183884013	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:183884013C>G	ENST00000313143.3	+	8	1111	c.863C>G	c.(862-864)gCt>gGt	p.A288G	DVL3_ENST00000431765.1_Missense_Mutation_p.A288G|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	288	PDZ.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GGGGCCGTGGCTGCTGATGGA	0.542000													11	106					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518386	8518386	+	Silent	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:8518386T>A	ENST00000381196.4	-	18	1548	c.1005A>T	c.(1003-1005)acA>acT	p.T335T	PTPRD_ENST00000540109.1_Silent_p.T335T|PTPRD_ENST00000360074.4_Silent_p.T322T|PTPRD_ENST00000537002.1_Silent_p.T332T|PTPRD_ENST00000358503.5_Silent_p.T322T|PTPRD_ENST00000486161.1_Silent_p.T335T|PTPRD_ENST00000356435.5_Silent_p.T335T|PTPRD_ENST00000355233.5_Silent_p.T335T|PTPRD_ENST00000397606.3_Silent_p.T325T|PTPRD_ENST00000397611.3_Silent_p.T332T|PTPRD_ENST00000397617.3_Silent_p.T325T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	335	Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGCTTGTAGCTGTGCTCTCGG	0.433000										TSP Lung(15;0.13)			34	94					0	0	1	0	0
BST2	684	broad.mit.edu	37	19	17516358	17516358	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:17516358G>T	ENST00000252593.6	-	1	99	c.27C>A	c.(25-27)tgC>tgA	p.C9*		NM_004335.2	NP_004326.1	Q10589	BST2_HUMAN	bone marrow stromal cell antigen 2	9					B cell activation|cell proliferation|cell-cell signaling|defense response to virus|humoral immune response|innate immune response|multicellular organismal development|positive regulation of I-kappaB kinase/NF-kappaB cascade	anchored to membrane|Golgi apparatus|integral to plasma membrane|late endosome	protein homodimerization activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(2)	9						TGGGCACTCTGCAATAGTCAT	0.522000													28	71					3.65163e-15	5.30492e-15	1	1	0
DCSTAMP	81501	broad.mit.edu	37	8	105368406	105368406	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:105368406G>A	ENST00000297581.2	+	4	1442	c.1393G>A	c.(1393-1395)Gca>Aca	p.A465T	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000520080.1_3'UTR|DCSTAMP_ENST00000517991.1_3'UTR	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	465					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											AATGGACATGGCAAGTGCAGA	0.463000													6	42					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41061673	41061673	+	Splice_Site	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:41061673T>A	ENST00000399564.4	-	6	1064	c.615_splice	c.e6+1	p.Q205_splice		NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CCCACTCACCTGCATGGGTGA	0.478000													42	194					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723793	142723793	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:142723793C>T	ENST00000350513.2	-	1	489	c.427G>A	c.(427-429)Gtg>Atg	p.V143M		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					ACCCATGACACTATTACCACC	0.408000													16	127					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226553694	226553694	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:226553694A>G	ENST00000366794.5	-	18	2609	c.2466T>C	c.(2464-2466)caT>caC	p.H822H	PARP1_ENST00000490921.1_5'UTR	NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	822	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GTGTGGTTGCATGAGTGTTCT	0.473000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					13	94					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32190534	32190534	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:32190534G>A	ENST00000375023.3	-	3	343	c.205C>T	c.(205-207)Cag>Tag	p.Q69*		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	69	EGF-like 2.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						TGGGCGTTCTGGCAGGGGTCA	0.612000													12	53					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54527930	54527930	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:54527930G>T	ENST00000373968.3	-	4	778	c.714C>A	c.(712-714)acC>acA	p.T238T		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	238	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CCAGATGGGAGGTGGAGCAGG	0.498000													18	321					3.41278e-10	4.52992e-10	1	1	0
REG3A	5068	broad.mit.edu	37	2	79384799	79384799	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:79384799C>G	ENST00000393878.1	-	4	613	c.359G>C	c.(358-360)tGg>tCg	p.W120S	REG3A_ENST00000305165.2_Missense_Mutation_p.W120S|REG3A_ENST00000409839.3_Missense_Mutation_p.W120S	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	120	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						ACTCCACTCCCAACCTTCTCC	0.552000													30	105					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069101	21069101	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:21069101G>T	ENST00000381545.3	+	16	2248	c.2029G>T	c.(2029-2031)Ggt>Tgt	p.G677C	LST3_ENST00000381541.3_Intron|LST3_ENST00000540229.1_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G677C|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	677					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CTTAAATAATGGTGAACATTT	0.333000													11	66					0.0692343	0.0715615	1	1	0
C1orf106	55765	broad.mit.edu	37	1	200860813	200860813	+	Silent	SNP	A	A	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:200860813A>C	ENST00000367342.4	+	1	345	c.145A>C	c.(145-147)Aga>Cga	p.R49R		NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	49										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GGGCGGCGCCAGAGCTCCATG	0.687000													5	12					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70201823	70201823	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:70201823A>G	ENST00000253925.7	+	18	2609	c.2394A>G	c.(2392-2394)ccA>ccG	p.P798P	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.P798P	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	798					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			ACAAAGCCCCAAAGAAGAAAG	0.527000													45	57					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746535	47746535	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:47746535C>A	ENST00000273857.4	-	5	682	c.683G>T	c.(682-684)gGg>gTg	p.G228V	CORIN_ENST00000505909.1_Missense_Mutation_p.G228V|CORIN_ENST00000504584.1_Missense_Mutation_p.G228V|CORIN_ENST00000502252.1_Missense_Mutation_p.G161V|CORIN_ENST00000508498.1_Missense_Mutation_p.G89V	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	228	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						ATTCACCATCCCCAGGACTGA	0.453000													61	187					1.1362e-29	1.96834e-29	1	1	0
PDGFRB	5159	broad.mit.edu	37	5	149515136	149515136	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:149515136G>T	ENST00000261799.4	-	3	815	c.346C>A	c.(346-348)Ctc>Atc	p.L116I		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	116	Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AAGATGTAGAGCCGTTTCCGC	0.562000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								48	156					5.13769e-22	8.24264e-22	1	1	0
ZNF536	9745	broad.mit.edu	37	19	31038849	31038849	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:31038849G>A	ENST00000355537.3	+	4	2470		c.e4-1			NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAATCTTGCAGGTGAGAAACC	0.463000													22	104					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043328	71043328	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:71043328T>G	ENST00000272367.2	-	4	1261	c.1185A>C	c.(1183-1185)caA>caC	p.Q395H	CLEC4F_ENST00000426626.1_Missense_Mutation_p.Q395H	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	395					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TCTTCATTCCTTGTTTTAGGG	0.438000													13	93					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9613325	9613325	+	Silent	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:9613325G>C	ENST00000570827.2	+	13	2205	c.1131G>C	c.(1129-1131)acG>acC	p.T377T	USP43_ENST00000285199.6_Silent_p.T688T|USP43_ENST00000570475.1_Silent_p.T683T			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	688					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						ATGACAGCACGGTGGAACCGC	0.542000													15	42					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93199083	93199083	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:93199083C>A	ENST00000393218.2	-	3	386	c.49G>T	c.(49-51)Gcc>Tcc	p.A17S	LGMN_ENST00000334869.4_Missense_Mutation_p.A17S|LGMN_ENST00000555699.1_Missense_Mutation_p.A17S|LGMN_ENST00000557434.1_Missense_Mutation_p.A17S	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	17					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		ATAGGAACGGCACCAATGCCC	0.483000													29	134					2.4375e-19	3.71668e-19	1	1	0
CBFA2T3	863	broad.mit.edu	37	16	88958857	88958857	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:88958857T>C	ENST00000268679.4	-	4	812	c.416A>G	c.(415-417)aAt>aGt	p.N139S	CBFA2T3_ENST00000436887.2_Missense_Mutation_p.N114S|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.N53S|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.N53S|CBFA2T3_ENST00000448839.1_Missense_Mutation_p.N63S	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	139	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CGGTGCACCATTGATGGCTGT	0.637000			T	RUNX1	AML								19	77					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238050678	238050678	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:238050678C>A	ENST00000366570.4	-	5	895	c.737G>T	c.(736-738)aGa>aTa	p.R246I	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	246	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCTCACCTGTCTTGTGGTGCC	0.507000													47	102					2.81731e-22	4.53968e-22	1	1	0
ARID1B	57492	broad.mit.edu	37	6	157522483	157522483	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:157522483C>T	ENST00000346085.5	+	18	4756	c.4755C>T	c.(4753-4755)ccC>ccT	p.P1585P	ARID1B_ENST00000275248.4_Silent_p.P1567P|ARID1B_ENST00000367148.1_Silent_p.P1625P|ARID1B_ENST00000350026.5_Silent_p.P1572P	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1572	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AGGTCATGCCCACGGTCCCCA	0.602000													22	158					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21263906	21263906	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:21263906T>C	ENST00000233242.1	-	4	414	c.287A>G	c.(286-288)cAg>cGg	p.Q96R	APOB_ENST00000399256.4_Missense_Mutation_p.Q96R	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	96	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGGGTGCACTGGCTGGTCTT	0.512000													10	58					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097487	167097487	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:167097487A>G	ENST00000361200.2	+	6	3285	c.3119A>G	c.(3118-3120)tAc>tGc	p.Y1040C	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.Y1040C|DUSP27_ENST00000271385.5_Missense_Mutation_p.Y1040C			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1040					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGAGCCCTACTTCTTCCGC	0.582000													21	66					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71411575	71411575	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:71411575G>T	ENST00000302628.4	+	4	344	c.267G>T	c.(265-267)gcG>gcT	p.A89A	CALB2_ENST00000349553.5_Silent_p.A89A	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	89	EF-hand 2.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				CACAGCTGGCGCAGATCCTGC	0.552000													24	77					5.45024e-15	7.85601e-15	1	1	0
KCNIP4	80333	broad.mit.edu	37	4	20852205	20852205	+	Silent	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:20852205G>C	ENST00000382148.3	-	2	510	c.174C>G	c.(172-174)acC>acG	p.T58T	KCNIP4_ENST00000382152.2_Silent_p.T83T|KCNIP4_ENST00000382150.4_Silent_p.T62T|KCNIP4_ENST00000509207.1_Silent_p.T21T|KCNIP4_ENST00000447367.2_Silent_p.T49T|KCNIP4_ENST00000359001.5_Silent_p.T21T|KCNIP4_ENST00000382149.4_5'UTR	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	83						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				GCTCTTTCTTGGTAAATTTGC	0.453000													29	95					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411800	39411800	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:39411800A>G	ENST00000394008.1	+	1	165	c.163A>G	c.(163-165)Acc>Gcc	p.T55A		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	55						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CTGTCAAAACACCTGCTGCAG	0.642000													16	77					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17601240	17601240	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:17601240C>G	ENST00000381869.3	-	3	2633	c.2160G>C	c.(2158-2160)agG>agC	p.R720S	MTUS1_ENST00000519263.1_Missense_Mutation_p.R720S|MTUS1_ENST00000381862.3_Missense_Mutation_p.R720S|MTUS1_ENST00000262102.6_Missense_Mutation_p.R720S	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	720						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CAGCTATTTGCCTCAAACCGC	0.483000													21	93					0	0	1	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001277	13001277	+	Missense_Mutation	SNP	G	G	T	rs139593649		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:13001277G>T	ENST00000376189.1	-	3	505	c.406C>A	c.(406-408)Cag>Aag	p.Q136K	PRAMEF6_ENST00000376192.5_Intron|PRAMEF6_ENST00000415464.2_Missense_Mutation_p.Q136K	NM_001010889.2	NP_001010889.1	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	136										NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGACAGTCCTGCACTGGTGTT	0.507000													116	897					4.82855e-46	8.6914e-46	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113169428	113169428	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:113169428C>T	ENST00000401783.2	-	38	8788	c.8452G>A	c.(8452-8454)Gac>Aac	p.D2818N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D2795N|SVEP1_ENST00000297826.5_Missense_Mutation_p.D744N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2818	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CAGTTTTTGTCATCCTGGCAT	0.502000													45	158					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158157473	158157473	+	Missense_Mutation	SNP	C	C	G	rs141104683		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:158157473C>G	ENST00000259056.4	+	7	2886	c.2401C>G	c.(2401-2403)Cct>Gct	p.P801A	GALNT5_ENST00000463418.1_3'UTR	NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	801					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						GAATGTCTTTCCTGACTTAAG	0.418000													16	56					0	0	1	0	0
PIGN	23556	broad.mit.edu	37	18	59757811	59757811	+	Splice_Site	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:59757811C>T	ENST00000357637.5	-	24	2596	c.2180_splice	c.e24-1	p.G727_splice	PIGN_ENST00000400334.3_Splice_Site_p.G727_splice	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	727					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				GAGCTTCATACCTAACAGGTG	0.318000													5	20					0	0	1	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75804383	75804383	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:75804383G>T	ENST00000550916.1	+	2	451	c.404G>T	c.(403-405)aGa>aTa	p.R135I	GLIPR1L2_ENST00000378692.3_Missense_Mutation_p.R28I|GLIPR1L2_ENST00000441218.1_Missense_Mutation_p.R70I|GLIPR1L2_ENST00000320460.4_Missense_Mutation_p.R135I|GLIPR1L2_ENST00000547164.1_Missense_Mutation_p.R135I|GLIPR1L2_ENST00000435775.1_Missense_Mutation_p.R135I	NM_001270396.1	NP_001257325.1	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	135						integral to membrane				kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16						ATTGCTATCAGAAGTTGGCAT	0.323000													26	100					5.45024e-15	7.85601e-15	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113651026	113651026	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:113651026G>T	ENST00000297405.5	-	21	3669	c.3425C>A	c.(3424-3426)cCt>cAt	p.P1142H	CSMD3_ENST00000343508.3_Missense_Mutation_p.P1102H|CSMD3_ENST00000455883.2_Missense_Mutation_p.P1038H|CSMD3_ENST00000352409.3_Missense_Mutation_p.P1142H	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1142	CUB 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GATTGTTGGAGGAAGATCTGA	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	73					0.000308642	0.000337949	1	1	0
STK11	6794	broad.mit.edu	37	19	1220649	1220649	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:1220649G>T	ENST00000326873.7	+	5	1840	c.667G>T	c.(667-669)Gag>Tag	p.E223*		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	223	Protein kinase.		E -> V (in sporadic cancer; somatic mutation; impairs heterotrimeric complex assembly with STRADA and CAB39).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.E223*(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGCCGCCCGAGATTGCCAA	0.697000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			14	13					0.000219431	0.000243886	1	1	0
GPR112	139378	broad.mit.edu	37	X	135453630	135453630	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:135453630A>T	ENST00000394143.1	+	14	7831	c.7540A>T	c.(7540-7542)Atg>Ttg	p.M2514L	GPR112_ENST00000287534.4_Missense_Mutation_p.M2312L|GPR112_ENST00000394141.1_Missense_Mutation_p.M2309L|GPR112_ENST00000370652.1_Missense_Mutation_p.M2514L|GPR112_ENST00000412101.1_Missense_Mutation_p.M2309L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2514					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AACTCATGTTATGTTACAAAT	0.338000													10	38					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746747	57746747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:57746747C>T	ENST00000302804.7	+	7	1078	c.892C>T	c.(892-894)Cga>Tga	p.R298*	AURKC_ENST00000448930.1_Nonsense_Mutation_p.R264*|AURKC_ENST00000415300.2_Nonsense_Mutation_p.R279*|AURKC_ENST00000598785.1_Nonsense_Mutation_p.R264*|AURKC_ENST00000599062.1_Nonsense_Mutation_p.R295*	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	298					cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GGCCCACTCCCGAAGGGTGCT	0.622000													6	103					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326934	142326934	+	RNA	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:142326934G>T	ENST00000390393.3	+	0	440																											TCAGAAAGGAGATATAGCTGA	0.483000													36	198					4.65686e-17	6.92896e-17	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49446173	49446173	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:49446173C>A	ENST00000301067.7	-	10	1292	c.1293G>T	c.(1291-1293)gaG>gaT	p.E431D		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTAGGGGGGCCTCCAACTGGG	0.592000													10	34					1.58986e-06	1.86834e-06	1	1	0
ULK4	54986	broad.mit.edu	37	3	41973472	41973472	+	Silent	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:41973472C>G	ENST00000301831.4	-	5	867	c.405G>C	c.(403-405)ctG>ctC	p.L135L	ULK4_ENST00000420927.1_Silent_p.L135L	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	135	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TGCTAAACTTCAGTGTGCCAG	0.368000													31	114					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103149117	103149117	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:103149117G>T	ENST00000295269.4	+	12	2824	c.2367G>T	c.(2365-2367)agG>agT	p.R789S		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	789					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ACCATCACAGGTCCCATAGTC	0.493000													6	39					0.00307968	0.00327493	1	1	0
CHST6	4166	broad.mit.edu	37	16	75513129	75513129	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:75513129G>T	ENST00000332272.4	-	3	777	c.598C>A	c.(598-600)Ctg>Atg	p.L200M	CHST6_ENST00000390664.2_Missense_Mutation_p.L200M|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	200			L -> R (in MCD; dbSNP:rs28937879).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TCGCGCACCAGGTGCACGATG	0.677000													18	49					8.10497e-08	9.83794e-08	1	1	0
NLRP3	114548	broad.mit.edu	37	1	247587673	247587673	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:247587673G>T	ENST00000366497.2	+	4	1708	c.928G>T	c.(928-930)Gcc>Tcc	p.A310S	NLRP3_ENST00000348069.2_Missense_Mutation_p.A310S|NLRP3_ENST00000366496.2_Missense_Mutation_p.A310S|NLRP3_ENST00000391828.3_Missense_Mutation_p.A310S|NLRP3_ENST00000336119.3_Missense_Mutation_p.A310S|NLRP3_ENST00000391827.2_Missense_Mutation_p.A310S|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	310	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCAAGGTGCCTTTGACGA	0.572000													43	116					3.54909e-21	5.5258e-21	1	1	0
MUC17	140453	broad.mit.edu	37	7	100677445	100677445	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:100677445C>T	ENST00000306151.4	+	3	2812	c.2748C>T	c.(2746-2748)acC>acT	p.T916T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	916	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCATGCCAACCTCAACTCCTG	0.512000													29	664					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52488588	52488588	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:52488588G>A	ENST00000261839.7	-	39	5074	c.4913C>T	c.(4912-4914)gCc>gTc	p.A1638V	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1638	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AAGCAACCAGGCTGCCTGAGA	0.502000													5	62					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10428288	10428288	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:10428288T>C	ENST00000245503.5	-	34	5141	c.4757A>G	c.(4756-4758)gAt>gGt	p.D1586G	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.D1586G|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1586					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						AATTTCCTCATCTTTTTCAGC	0.448000													38	159					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41587902	41587902	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:41587902C>T	ENST00000402685.2	+	3	763	c.755C>T	c.(754-756)tCg>tTg	p.S252L		NM_001164595.1	NP_001158067.1	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	252	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGAACATCGACTGAAGGA	0.318000													14	37					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230679845	230679845	+	Silent	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:230679845T>A	ENST00000283943.5	-	10	1735	c.1557A>T	c.(1555-1557)gtA>gtT	p.V519V	TRIP12_ENST00000389044.4_Silent_p.V567V|TRIP12_ENST00000389045.3_Silent_p.V222V|TRIP12_ENST00000543084.1_Intron	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	519					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TAGCATCTACTACAACAGCAG	0.373000													40	221					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131188650	131188650	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:131188650T>A	ENST00000337057.3	-	16	2860	c.2679A>T	c.(2677-2679)gaA>gaT	p.E893D	EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Missense_Mutation_p.E635D|EPB41L2_ENST00000528282.1_Missense_Mutation_p.E635D|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000368128.2_Missense_Mutation_p.E893D|EPB41L2_ENST00000530757.1_Missense_Mutation_p.E122D|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000524581.1_Missense_Mutation_p.E271D|EPB41L2_ENST00000527659.1_Intron|EPB41L2_ENST00000529208.1_Missense_Mutation_p.E823D|EPB41L2_ENST00000527411.1_Missense_Mutation_p.E823D|EPB41L2_ENST00000530481.1_Missense_Mutation_p.E740D	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	893	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAATGGGGACTTCCTTGGTGG	0.433000													21	133					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107961207	107961207	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:107961207C>A	ENST00000370067.1	+	6	1720	c.1093C>A	c.(1093-1095)Cca>Aca	p.P365T	NTNG1_ENST00000370065.1_Intron|NTNG1_ENST00000370066.1_Missense_Mutation_p.P365T|NTNG1_ENST00000370068.1_Intron|NTNG1_ENST00000370061.3_Missense_Mutation_p.P365T|NTNG1_ENST00000370070.2_Missense_Mutation_p.P365T|NTNG1_ENST00000370071.2_Missense_Mutation_p.P365T|NTNG1_ENST00000370073.2_Intron|NTNG1_ENST00000370074.4_Intron|NTNG1_ENST00000370072.3_Intron|NTNG1_ENST00000542803.1_Intron			Q9Y2I2	NTNG1_HUMAN	netrin G1	365	Laminin EGF-like 2.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		TGCAGATCCTCCAAAGTTTAA	0.368000													4	13					0.00909568	0.00956213	1	1	0
LPO	4025	broad.mit.edu	37	17	56344885	56344885	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:56344885G>T	ENST00000262290.4	+	12	2185	c.1869G>T	c.(1867-1869)cgG>cgT	p.R623R	LPO_ENST00000543544.1_Silent_p.R564R|LPO_ENST00000421678.2_Silent_p.R540R|LPO_ENST00000582328.1_Silent_p.R540R	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	623					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						AAAGGGGTCGGGTGGGGCCTC	0.622000													15	56					0.479597	0.4809	1	1	0
LRRTM4	80059	broad.mit.edu	37	2	77746674	77746674	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:77746674C>A	ENST00000409088.3	-	3	735	c.321G>T	c.(319-321)ggG>ggT	p.G107G	LRRTM4_ENST00000409093.1_Silent_p.G107G|LRRTM4_ENST00000409282.1_Silent_p.G108G|LRRTM4_ENST00000409884.1_Silent_p.G107G|LRRTM4_ENST00000409911.1_Silent_p.G108G	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	107						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GTCTACGGATCCCTTGAAATG	0.393000													22	70					2.98393e-07	3.57491e-07	1	1	0
CHDC2	286464	broad.mit.edu	37	X	36091481	36091481	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:36091481G>C	ENST00000378660.1	+	4	604	c.416_splice	c.e4+1	p.R139_splice	CHDC2_ENST00000313548.4_Splice_Site_p.R139_splice					calponin homology domain containing 2																		ACTATAAGAAGGTGAGAGTCC	0.343000													30	46					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79375746	79375746	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:79375746G>T	ENST00000350881.2	+	20	2720	c.2530G>T	c.(2530-2532)Ggt>Tgt	p.G844C	THBS4_ENST00000511733.1_Missense_Mutation_p.G753C|THBS4_ENST00000504720.1_3'UTR|CTD-2201I18.1_ENST00000514042.1_RNA|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	844	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTCTAAGACAGGTCCAGGGGA	0.567000													17	75					1.33834e-09	1.73279e-09	1	1	0
MACF1	23499	broad.mit.edu	37	1	39812877	39812877	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:39812877G>T	ENST00000564288.1	+	41	11587	c.10810G>T	c.(10810-10812)Gtg>Ttg	p.V3604L	MACF1_ENST00000567887.1_Missense_Mutation_p.V3641L|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.V2044L|MACF1_ENST00000372915.3_Missense_Mutation_p.V3609L|MACF1_ENST00000545844.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3609					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGAAGCCCTGGTGAAGGTCAG	0.522000													7	34					0.248553	0.249907	1	1	0
NCKAP5L	57701	broad.mit.edu	37	12	50190322	50190322	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:50190322G>A	ENST00000335999.6	-	8	1522	c.1321C>T	c.(1321-1323)Cct>Tct	p.P441S		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	437	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						GCTTCCCCAGGAGAAGGGGGG	0.617000													7	33					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158272292	158272292	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:158272292C>A	ENST00000264192.3	-	8	1098	c.977G>T	c.(976-978)gGg>gTg	p.G326V	CYTIP_ENST00000540637.1_Missense_Mutation_p.G220V	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	326					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						GGGCAGGGTCCCAAACATGCT	0.512000													17	93					2.35188e-11	3.26257e-11	1	1	0
FAM83B	222584	broad.mit.edu	37	6	54804555	54804555	+	Silent	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:54804555A>T	ENST00000306858.7	+	5	902	c.786A>T	c.(784-786)acA>acT	p.T262T		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	262										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AGATAATTACAGGACAACTTG	0.363000													17	101					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8341179	8341179	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:8341179C>A	ENST00000381196.4	-	38	5580	c.5037G>T	c.(5035-5037)atG>atT	p.M1679I	PTPRD_ENST00000540109.1_Missense_Mutation_p.M1679I|PTPRD_ENST00000360074.4_Missense_Mutation_p.M1666I|PTPRD_ENST00000397617.3_Missense_Mutation_p.M1272I|PTPRD_ENST00000537002.1_Missense_Mutation_p.M1269I|PTPRD_ENST00000358503.5_Missense_Mutation_p.M1657I|PTPRD_ENST00000486161.1_Missense_Mutation_p.M1272I|PTPRD_ENST00000356435.5_Missense_Mutation_p.M1679I|PTPRD_ENST00000355233.5_Missense_Mutation_p.M1273I|PTPRD_ENST00000397606.3_Missense_Mutation_p.M1272I|PTPRD_ENST00000397611.3_Missense_Mutation_p.M1269I	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1679	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTCATATGGCATAATATTAA	0.398000										TSP Lung(15;0.13)			53	170					5.22555e-25	8.68572e-25	1	1	0
ORAI1	84876	broad.mit.edu	37	12	122079143	122079143	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:122079143G>T	ENST00000330079.7	+	2	699	c.506G>T	c.(505-507)cGc>cTc	p.R169L		NM_032790.3	NP_116179.2	Q96D31	CRCM1_HUMAN	ORAI calcium release-activated calcium modulator 1	167					platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		CCCCATGAGCGCATGCACCGC	0.602000													4	56					0.150653	0.153567	1	1	0
PLD1	5337	broad.mit.edu	37	3	171406513	171406513	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:171406513C>T	ENST00000356327.5	-	14	1562	c.1492G>A	c.(1492-1494)Ggc>Agc	p.G498S	PLD1_ENST00000340989.4_Missense_Mutation_p.G498S|PLD1_ENST00000351298.4_Missense_Mutation_p.G498S|PLD1_ENST00000342215.6_Missense_Mutation_p.G498S	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	498	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTCACACTGCCCACGTCTGTG	0.473000													17	72					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11520888	11520888	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:11520888G>T	ENST00000262442.3	+	5	1133	c.1065G>T	c.(1063-1065)ccG>ccT	p.P355P	DNAH9_ENST00000579406.1_3'UTR|DNAH9_ENST00000454412.2_Silent_p.P355P	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	355	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACCGCTCCCCGGGAAGGCTGA	0.622000													20	63					2.89027e-11	3.96472e-11	1	1	0
RSPO3	84870	broad.mit.edu	37	6	127471622	127471622	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:127471622G>T	ENST00000356698.4	+	3	930	c.341G>T	c.(340-342)tGt>tTt	p.C114F	RSPO3_ENST00000368317.3_Missense_Mutation_p.C114F|RSPO3_ENST00000485757.1_3'UTR	NM_032784.3	NP_116173.2	Q9BXY4	RSPO3_HUMAN	R-spondin 3	114						extracellular region	heparin binding		PTPRK/RSPO3(10)	breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17				GBM - Glioblastoma multiforme(226;0.0555)		TGCACAAAATGTAAAAGTGGA	0.368000													20	75					6.33239e-15	9.09203e-15	1	1	0
HFM1	164045	broad.mit.edu	37	1	91845681	91845681	+	Nonsense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:91845681A>T	ENST00000370425.3	-	8	1084	c.986T>A	c.(985-987)tTg>tAg	p.L329*	HFM1_ENST00000294696.5_5'UTR|HFM1_ENST00000370424.3_Nonsense_Mutation_p.L8*	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	329	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTAATATTCAACCATGGCAA	0.284000													15	96					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237948056	237948056	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:237948056G>A	ENST00000366574.2	+	90	13361	c.13044G>A	c.(13042-13044)gaG>gaA	p.E4348E	RYR2_ENST00000360064.6_Silent_p.E4354E|RYR2_ENST00000542537.1_Silent_p.E4332E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4348					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGGGGAGGAGGGAGAGAGGA	0.547000													14	108					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131883426	131883426	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:131883426G>T	ENST00000403716.1	+	3	698	c.138G>T	c.(136-138)aaG>aaT	p.K46N	PLEKHB2_ENST00000404460.1_Missense_Mutation_p.K46N|PLEKHB2_ENST00000538982.1_5'UTR|PLEKHB2_ENST00000234115.6_Missense_Mutation_p.K46N|PLEKHB2_ENST00000438882.2_Missense_Mutation_p.K46N|PLEKHB2_ENST00000303908.3_Missense_Mutation_p.K46N|PLEKHB2_ENST00000409279.1_Missense_Mutation_p.K46N|PLEKHB2_ENST00000439822.2_Missense_Mutation_p.K46N|PLEKHB2_ENST00000409612.1_Missense_Mutation_p.K46N|PLEKHB2_ENST00000409158.1_Missense_Mutation_p.K46N	NM_001100623.1|NM_001267062.1|NM_001267063.1|NM_001267064.1|NM_001267065.1|NM_001267066.1|NM_017958.2	NP_001094093.1|NP_001253991.1|NP_001253992.1|NP_001253993.1|NP_001253994.1|NP_001253995.1|NP_060428.2	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	46	PH.					membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		TCGAGGATAAGGTCCACATGC	0.502000													24	72					2.79863e-10	3.74165e-10	1	1	0
OR6Y1	391112	broad.mit.edu	37	1	158517445	158517445	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:158517445C>T	ENST00000302617.3	-	1	450	c.451G>A	c.(451-453)Gga>Aga	p.G151R		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CAGCATCCTCCAGCCAGTGTG	0.468000													10	87					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38830297	38830297	+	Silent	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:38830297C>G	ENST00000436693.2	-	2	917	c.798G>C	c.(796-798)ctG>ctC	p.L266L	TLR6_ENST00000381950.1_Silent_p.L266L	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	266					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGACTCTGACCAGGCATTTCC	0.333000													11	63					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54072640	54072640	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:54072640G>T	ENST00000253144.9	+	5	1342		c.e5+1		ZNF331_ENST00000513265.1_Splice_Site|ZNF331_ENST00000449416.1_Splice_Site|ZNF331_ENST00000411977.2_Splice_Site|ZNF331_ENST00000512387.1_Splice_Site|ZNF331_ENST00000511593.2_Splice_Site|ZNF331_ENST00000511154.1_Splice_Site|ZNF331_ENST00000513999.1_Splice_Site	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		AATGGCCCAGGTAAGTGTATA	0.403000			T	?	follicular thyroid adenoma								39	128					1.59932e-28	2.73218e-28	1	1	0
MANBA	4126	broad.mit.edu	37	4	103647806	103647806	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:103647806C>T	ENST00000226578.4	-	2	311	c.212G>A	c.(211-213)aGa>aAa	p.R71K	MANBA_ENST00000505239.1_Missense_Mutation_p.R71K	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	71					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		AGAGACCCATCTGTAGTTAAG	0.289000													27	98					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595901	36595901	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:36595901C>A	ENST00000299440.5	+	2	1159	c.1047C>A	c.(1045-1047)agC>agA	p.S349R		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	349					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				CCTTTCTGAGCGTCTTGAATT	0.458000									Familial Hemophagocytic Lymphohistiocytosis				9	74					1.12685e-05	1.27548e-05	1	1	0
CNKSR1	10256	broad.mit.edu	37	1	26513901	26513901	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:26513901G>T	ENST00000531191.1	+	15	1615		c.e15-1		CNKSR1_ENST00000361530.6_Splice_Site|CNKSR1_ENST00000374253.5_Splice_Site			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1						Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CTACCTGGCAGTGTGTTTCAG	0.592000													43	92					9.39024e-22	1.48712e-21	1	1	0
LMBR1L	55716	broad.mit.edu	37	12	49495284	49495284	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:49495284C>T	ENST00000267102.8	-	12	1321	c.979G>A	c.(979-981)Gat>Aat	p.D327N	LMBR1L_ENST00000395141.4_Missense_Mutation_p.D322N|LMBR1L_ENST00000547382.1_Missense_Mutation_p.D327N	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	327					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GCAGCCTCATCGATGAGCAGC	0.612000													9	34					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002185	98002185	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:98002185T>A	ENST00000355273.2	+	1	454	c.454T>A	c.(454-456)Ttc>Atc	p.F152I	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GCTGTTAGCCTTCTCATTTTT	0.363000													22	89					0	0	1	0	0
C3orf58	205428	broad.mit.edu	37	3	143704408	143704408	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:143704408G>T	ENST00000315691.3	+	2	1216	c.681G>T	c.(679-681)tgG>tgT	p.W227C	C3orf58_ENST00000495414.1_Missense_Mutation_p.W18C|C3orf58_ENST00000441925.2_5'UTR|C3orf58_ENST00000493396.1_Intron	NM_173552.3	NP_775823.1	Q8NDZ4	CC058_HUMAN	chromosome 3 open reading frame 58	227						COPI vesicle coat|extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ATGAAGGTTGGCCATTTGCAA	0.383000													30	155					2.2171e-23	3.65228e-23	1	1	0
COL6A5	256076	broad.mit.edu	37	3	130159236	130159236	+	Silent	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:130159236T>C	ENST00000265379.6	+	35	6548	c.6054T>C	c.(6052-6054)agT>agC	p.S2018S	COL6A5_ENST00000432398.2_Silent_p.S2018S			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2018	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CTTGGGAAAGTTCCAGGAGAA	0.413000													26	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641392	179641392	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:179641392C>A	ENST00000589042.1	-	28	5423	c.5199G>T	c.(5197-5199)acG>acT	p.T1733T	TTN_ENST00000359218.5_Silent_p.T1687T|TTN_ENST00000591111.1_Silent_p.T1733T|TTN_ENST00000460472.2_Silent_p.T1687T|TTN_ENST00000360870.5_Silent_p.T1733T|TTN_ENST00000342175.6_Silent_p.T1687T|TTN_ENST00000342992.6_Silent_p.T1733T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1485	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACCACCATCGTTGGGTCAC	0.473000													23	60					3.8784e-16	5.70172e-16	1	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603730	140603730	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:140603730G>T	ENST00000239449.4	+	1	653	c.653G>T	c.(652-654)gGa>gTa	p.G218V	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G65V	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		218	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGGATGGTGGATCCCCGCCC	0.463000													37	109					6.53348e-20	1.00873e-19	1	1	0
NTNG1	22854	broad.mit.edu	37	1	107979390	107979390	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:107979390G>T	ENST00000370068.1	+	7	2205	c.1359G>T	c.(1357-1359)ctG>ctT	p.L453L	NTNG1_ENST00000370065.1_Intron|NTNG1_ENST00000370066.1_Intron|NTNG1_ENST00000370067.1_Intron|NTNG1_ENST00000370061.3_Silent_p.L419L|NTNG1_ENST00000370070.2_Intron|NTNG1_ENST00000370071.2_Intron|NTNG1_ENST00000370073.2_Silent_p.L453L|NTNG1_ENST00000370074.4_Intron|NTNG1_ENST00000370072.3_Intron|NTNG1_ENST00000542803.1_Silent_p.L453L			Q9Y2I2	NTNG1_HUMAN	netrin G1	453	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		ATGAGTGTCTGCCGGGAAATT	0.517000													8	47					0.000274275	0.000301213	1	1	0
KIR2DL1	3802	broad.mit.edu	37	19	55290114	55290114	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:55290114G>T	ENST00000336077.6	+	5	755	c.715_splice	c.e5+1	p.G239_splice	KIR2DL4_ENST00000396284.2_Intron|KIR2DL3_ENST00000434419.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR2DL1_ENST00000291633.7_Splice_Site_p.E239_splice|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	239					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CTCCAAAACCGGTGAGTACAG	0.507000													12	179					3.27435e-08	4.08188e-08	1	1	0
ADAM32	203102	broad.mit.edu	37	8	39080570	39080570	+	Silent	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:39080570A>T	ENST00000379907.4	+	14	1465	c.1338A>T	c.(1336-1338)tcA>tcT	p.S446S	ADAM32_ENST00000437682.2_Silent_p.S347S|ADAM32_ENST00000519315.1_Silent_p.S340S	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	446	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TTTTACAATCAGGCGTTGAAT	0.323000													3	16					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396947	154396947	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:154396947G>T	ENST00000435029.4	+	1	3688	c.3528G>T	c.(3526-3528)gaG>gaT	p.E1176D		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1176	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTGACATGGAGCAGGTGCTGT	0.512000													18	51					1.33834e-09	1.73279e-09	1	1	0
CALU	813	broad.mit.edu	37	7	128398933	128398933	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:128398933G>T	ENST00000542996.2	+	5	1391	c.448G>T	c.(448-450)Gat>Tat	p.D150Y	CALU_ENST00000479257.1_Missense_Mutation_p.D150Y|CALU_ENST00000538546.1_5'UTR|CALU_ENST00000535623.1_3'UTR|CALU_ENST00000535011.2_Missense_Mutation_p.D142Y|CALU_ENST00000449187.2_Missense_Mutation_p.D142Y|CALU_ENST00000249364.4_Missense_Mutation_p.D142Y	NM_001199672.1	NP_001186601.1	O43852	CALU_HUMAN	calumenin	142					platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						AGATGATCCAGATCCTGATGA	0.363000													44	166					7.05121e-23	1.15128e-22	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25321105	25321105	+	RNA	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:25321105C>A	ENST00000549804.2	+	0	1109				SNORD116-11_ENST00000383882.1_RNA																							TACGTGGGTTCCTTGGAAAGT	0.438000													19	70					4.96729e-08	6.1302e-08	1	1	0
SORCS3	22986	broad.mit.edu	37	10	106959756	106959756	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:106959756G>A	ENST00000369701.3	+	15	2236		c.e15-1		SORCS3_ENST00000369699.4_Splice_Site	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3							integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TAAACACTTAGAGTTTTTGGC	0.493000													34	60					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35507481	35507481	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr20:35507481C>A	ENST00000217320.3	+	3	271	c.227C>A	c.(226-228)cCc>cAc	p.P76H	TLDC2_ENST00000602922.1_Missense_Mutation_p.P76H	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		ACCGGCCATCCCTGGAGTCTG	0.632000													45	102					3.39706e-21	5.3115e-21	1	1	0
SNAP91	9892	broad.mit.edu	37	6	84300969	84300969	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:84300969C>A	ENST00000428679.2	-	22	2568	c.1975G>T	c.(1975-1977)Gct>Tct	p.A659S	SNAP91_ENST00000520302.1_Missense_Mutation_p.A629S|SNAP91_ENST00000195649.6_Missense_Mutation_p.A659S|SNAP91_ENST00000521485.1_Missense_Mutation_p.A659S|SNAP91_ENST00000521743.1_Missense_Mutation_p.A659S|SNAP91_ENST00000369694.2_Missense_Mutation_p.A659S|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000439399.2_Missense_Mutation_p.A659S|SNAP91_ENST00000437520.1_Intron			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	659					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CTAGAAGCAGCCTGAGATGCA	0.363000													15	83					5.03518e-11	6.85602e-11	1	1	0
KIAA1468	57614	broad.mit.edu	37	18	59919898	59919898	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:59919898C>A	ENST00000256858.6	+	12	1983	c.1733_splice	c.e12-1	p.Q579_splice	KIAA1468_ENST00000398130.2_Splice_Site_p.Q579_splice			Q9P260	K1468_HUMAN	KIAA1468	579							binding	p.Q579K(3)		autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				ATTTTTCAGGCAAATGATACT	0.383000													10	72					1.33987e-11	1.86571e-11	1	1	0
KLK6	5653	broad.mit.edu	37	19	51466621	51466621	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:51466621C>A	ENST00000376851.3	-	4	821	c.382G>T	c.(382-384)Gag>Tag	p.E128*	KLK6_ENST00000594641.1_Nonsense_Mutation_p.E128*|KLK6_ENST00000456750.2_Nonsense_Mutation_p.E21*|KLK6_ENST00000391808.1_Nonsense_Mutation_p.E21*|CTB-147C22.8_ENST00000601506.1_RNA|KLK6_ENST00000310157.2_Nonsense_Mutation_p.E128*|KLK6_ENST00000376853.4_Intron	NM_001012964.1	NP_001012982.1	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6	128	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|skin(4)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		CAGTCCCTCTCCAGGGGAAGG	0.622000													12	57					1.08611e-07	1.30972e-07	1	1	0
PBRM1	55193	broad.mit.edu	37	3	52623110	52623110	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:52623110C>G	ENST00000356770.4	-	17	2847	c.2845G>C	c.(2845-2847)Gaa>Caa	p.E949Q	PBRM1_ENST00000394830.3_Missense_Mutation_p.E981Q|PBRM1_ENST00000337303.4_Missense_Mutation_p.E981Q|PBRM1_ENST00000296302.7_Missense_Mutation_p.E981Q|PBRM1_ENST00000410007.1_Missense_Mutation_p.E981Q|PBRM1_ENST00000409767.1_Missense_Mutation_p.E996Q|PBRM1_ENST00000409114.3_Missense_Mutation_p.E996Q|PBRM1_ENST00000409057.1_Missense_Mutation_p.E981Q			Q86U86	PB1_HUMAN	polybromo 1	981					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.E981*(2)|p.E949*(1)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CACAGTCTTTCAATACAGACG	0.428000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								13	213					0	0	1	0	0
OS9	10956	broad.mit.edu	37	12	58109550	58109550	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:58109550G>T	ENST00000315970.7	+	6	628	c.587G>T	c.(586-588)tGt>tTt	p.C196F	OS9_ENST00000551035.1_Missense_Mutation_p.C163F|OS9_ENST00000435406.2_Missense_Mutation_p.C144F|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000257966.8_Missense_Mutation_p.C196F|OS9_ENST00000439210.2_Missense_Mutation_p.C137F|OS9_ENST00000552285.1_Missense_Mutation_p.C196F|OS9_ENST00000413095.2_Intron|OS9_ENST00000389142.5_Missense_Mutation_p.C196F|OS9_ENST00000389146.6_Missense_Mutation_p.C196F	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	196					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CAGTTCCTCTGTGACGAGGGT	0.483000													11	53					0.0809354	0.0834222	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11520887	11520887	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:11520887C>T	ENST00000262442.3	+	5	1132	c.1064C>T	c.(1063-1065)cCg>cTg	p.P355L	DNAH9_ENST00000579406.1_3'UTR|DNAH9_ENST00000454412.2_Missense_Mutation_p.P355L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	355	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TACCGCTCCCCGGGAAGGCTG	0.622000													19	63					0	0	1	0	0
RAB8B	51762	broad.mit.edu	37	15	63548753	63548753	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:63548753T>C	ENST00000321437.4	+	5	530	c.374T>C	c.(373-375)aTg>aCg	p.M125T	RAB8B_ENST00000448330.2_Missense_Mutation_p.M125T	NM_016530.2	NP_057614.1	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	125					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			kidney(3)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9						AAATGTGATATGAATGACAAA	0.383000													22	56					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11562003	11562003	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:11562003C>T	ENST00000294484.6	+	2	1092	c.954C>T	c.(952-954)ccC>ccT	p.P318P	PTCHD2_ENST00000389575.3_Silent_p.P318P	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	318					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCTGGAAGCCCCACGAGGTGC	0.607000													4	51					0	0	1	0	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078276	90078276	+	RNA	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:90078276G>C	ENST00000390270.2	+	0	410																											TGAAGATTTTGCAGTGTATTA	0.488000													5	55					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137496707	137496707	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:137496707C>A	ENST00000254900.5	-	18	2671	c.2300G>T	c.(2299-2301)cGa>cTa	p.R767L	BRD8_ENST00000455658.2_Missense_Mutation_p.R726L|BRD8_ENST00000411594.2_Missense_Mutation_p.R770L|BRD8_ENST00000402931.1_Missense_Mutation_p.R767L|BRD8_ENST00000230901.5_Missense_Mutation_p.R840L|BRD8_ENST00000515014.1_5'UTR	NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	767	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AGCTGTGCTTCGGATCAGTCC	0.413000													7	102					0.00198382	0.00212182	1	1	0
POM121L12	285877	broad.mit.edu	37	7	53103524	53103524	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:53103524C>T	ENST00000408890.4	+	1	176	c.160C>T	c.(160-162)Ccc>Tcc	p.P54S		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	54										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GAGTCCCTGGCCCCTGAGGTC	0.701000													6	45					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28212297	28212297	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr21:28212297C>G	ENST00000284984.2	-	6	2203	c.1749G>C	c.(1747-1749)atG>atC	p.M583I		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	583	TSP type-1 1.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CACATTCCCTCATCGTGTACT	0.512000													36	85					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104314043	104314043	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:104314043G>T	ENST00000389120.3	+	11	1440	c.1350G>T	c.(1348-1350)aaG>aaT	p.K450N		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	450					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGGTCCGCAAGGAGTATGAAA	0.428000													25	70					9.57634e-11	1.29914e-10	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11593217	11593217	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:11593217G>T	ENST00000262442.3	+	20	4146	c.4078G>T	c.(4078-4080)Gaa>Taa	p.E1360*	DNAH9_ENST00000454412.2_Nonsense_Mutation_p.E1360*	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1360	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CACAGGCCTGGAAAGCACTGT	0.587000													4	20					0.150653	0.153567	1	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14757862	14757862	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:14757862C>T	ENST00000358984.4	+	5	846	c.666C>T	c.(664-666)ggC>ggT	p.G222G	ANKRD30B_ENST00000447268.2_Silent_p.G222G|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	222										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AGATAGTCGGCATGCTTCTTC	0.383000													11	44					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716375	13716375	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:13716375G>T	ENST00000279593.3	-	13	4006	c.3797C>A	c.(3796-3798)cCg>cAg	p.P1266Q		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1266					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGGGCAGCCGGCTGGTCCAG	0.587000													21	87					1.87028e-06	2.1909e-06	1	1	0
AIFM3	150209	broad.mit.edu	37	22	21332293	21332293	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr22:21332293G>T	ENST00000399167.2	+	16	1716	c.1477_splice	c.e16+1	p.Q492_splice	AIFM3_ENST00000333607.6_Splice_Site_p.Q492_splice|AIFM3_ENST00000335375.5_Splice_Site_p.Q480_splice|AIFM3_ENST00000399163.2_Splice_Site_p.Q492_splice|AIFM3_ENST00000465606.1_3'UTR|AIFM3_ENST00000405089.1_Splice_Site_p.Q498_splice|AIFM3_ENST00000440238.2_Splice_Site_p.Q492_splice	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTCATGCTCAGGGTATGGCCA	0.597000													11	29					4.3838e-07	5.20136e-07	1	1	0
DOCK10	55619	broad.mit.edu	37	2	225642911	225642911	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:225642911G>A	ENST00000409592.3	-	51	5841	c.5728C>T	c.(5728-5730)Ctc>Ttc	p.L1910F	DOCK10_ENST00000258390.7_Missense_Mutation_p.L1916F			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1916	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCTGCATAGAGCTTGAGTAAT	0.378000													14	22					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462498	228462498	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:228462498T>C	ENST00000570156.2	+	24	7108	c.7034T>C	c.(7033-7035)gTg>gCg	p.V2345A	RP5-1139B12.3_ENST00000602529.1_RNA|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.V1970A|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.V1970A|OBSCN_ENST00000359599.6_Missense_Mutation_p.V817A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1330	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGATCACCGTGGAGGCTGAG	0.647000													8	27					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533165	169533165	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:169533165C>A	ENST00000449804.2	+	1	249	c.204C>A	c.(202-204)ccC>ccA	p.P68P	FOXI1_ENST00000306268.6_Silent_p.P68P	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	68	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAACGGGCCCACCATGACCC	0.721000									Pendred syndrome				5	21					0.184627	0.187679	1	1	0
CCDC85A	114800	broad.mit.edu	37	2	56419635	56419635	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:56419635A>T	ENST00000407595.2	+	2	802	c.300A>T	c.(298-300)gaA>gaT	p.E100D	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	100										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AACTCCAGGAAGACAACCAGG	0.527000													7	95					0	0	1	0	0
C12orf60	144608	broad.mit.edu	37	12	14975885	14975885	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:14975885G>C	ENST00000330828.2	+	2	220	c.16G>C	c.(16-18)Gaa>Caa	p.E6Q	C12orf60_ENST00000527783.1_Intron	NM_175874.3	NP_787070.2	Q5U649	CL060_HUMAN	chromosome 12 open reading frame 60	6										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	9						TTCAGAGTCAGAAAAGGATAA	0.358000													7	127					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232649637	232649637	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:232649637C>A	ENST00000366630.1	-	2	1807	c.1449G>T	c.(1447-1449)ggG>ggT	p.G483G	SIPA1L2_ENST00000262861.4_Silent_p.G483G			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	483					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AATAATAGGCCCCAAGGTCAA	0.463000													52	263					3.07002e-29	5.269e-29	1	1	0
MUC16	94025	broad.mit.edu	37	19	9033621	9033621	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:9033621G>T	ENST00000397910.4	-	9	36519	c.36316C>A	c.(36316-36318)Ctg>Atg	p.L12106M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12108	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACCCTGCAGTTCTCTCTCT	0.607000													18	33					1.33834e-09	1.73279e-09	1	1	0
NRDE2	55051	broad.mit.edu	37	14	90756952	90756952	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:90756952C>A	ENST00000354366.3	-	10	2075		c.e10-1		NRDE2_ENST00000357904.3_Splice_Site	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CAAACAACACCTGCAACAAAG	0.413000													11	31					4.68919e-08	5.80641e-08	1	1	0
FAM151A	338094	broad.mit.edu	37	1	55078371	55078371	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:55078371C>A	ENST00000302250.2	-	5	748	c.588G>T	c.(586-588)ctG>ctT	p.L196L	FAM151A_ENST00000371304.2_Silent_p.L196L|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	196						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						TCTCCTGGACCAGGGCCAGGA	0.572000													12	58					1.08611e-07	1.30972e-07	1	1	0
ATXN10	25814	broad.mit.edu	37	22	46096245	46096245	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr22:46096245C>T	ENST00000252934.5	+	4	740	c.475C>T	c.(475-477)Cca>Tca	p.P159S	ATXN10_ENST00000381061.4_Missense_Mutation_p.P95S|ATXN10_ENST00000498009.1_3'UTR	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	159					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		GCATGCTTTCCCAGAACTGTT	0.353000													13	36					0	0	1	0	0
OR5K4	403278	broad.mit.edu	37	3	98073083	98073083	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:98073083C>A	ENST00000354924.2	+	1	386	c.386C>A	c.(385-387)cCa>cAa	p.P129Q	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						ATATGCCACCCACTGCAGTAC	0.488000													37	213					9.17885e-22	1.45991e-21	1	1	0
RXFP4	339403	broad.mit.edu	37	1	155912494	155912494	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:155912494T>A	ENST00000368318.3	+	1	1015	c.994T>A	c.(994-996)Tgg>Agg	p.W332R		NM_181885.2	NP_871001.1	Q8TDU9	RL3R2_HUMAN	relaxin/insulin-like family peptide receptor 4	332						integral to membrane|plasma membrane	angiotensin type II receptor activity			endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	13	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTTGAGGCTGTGGCCCCAGGG	0.662000													20	125					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3242137	3242137	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:3242137C>A	ENST00000217939.6	-	5	1743	c.1589G>T	c.(1588-1590)aGc>aTc	p.S530I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	530	Ig-like C2-type 1.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGAGAACTTGCTGTCTGGGTC	0.522000													4	47					0.00909568	0.00956213	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169126462	169126462	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:169126462G>C	ENST00000256935.8	+	12	1212	c.1132_splice	c.e12+1	p.G378_splice		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	378					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGAGGGCAAGGTAAAGTGCC	0.512000													7	85					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212587158	212587158	+	Silent	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:212587158T>G	ENST00000342788.4	-	7	1153	c.843A>C	c.(841-843)gcA>gcC	p.A281A	ERBB4_ENST00000402597.1_Silent_p.A281A|ERBB4_ENST00000436443.1_Silent_p.A281A	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	281	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATGTGTACTTTGCATTGAAAT	0.363000										TSP Lung(8;0.080)			14	55					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861397	55861397	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:55861397C>A	ENST00000302124.2	+	1	645	c.614C>A	c.(613-615)aCt>aAt	p.T205N	OR8I2_ENST00000560768.1_3'UTR			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					GCTGGATTCACTCTTCTTAGC	0.453000													16	111					1.5739e-10	2.11959e-10	1	1	0
HRAS	3265	broad.mit.edu	37	11	533462	533462	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:533462C>G	ENST00000417302.1	-	4	628	c.441G>C	c.(439-441)aaG>aaC	p.K147N	HRAS_ENST00000397596.2_Missense_Mutation_p.K147N|HRAS_ENST00000311189.7_Missense_Mutation_p.K147N|HRAS_ENST00000397594.1_Missense_Mutation_p.K147N|HRAS_ENST00000451590.1_Missense_Mutation_p.K147N	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	147					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCTGCCGGGTCTTGGCCGAGG	0.667000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			23	81					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48177607	48177607	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:48177607G>T	ENST00000418331.2	+	21	3726	c.3374G>T	c.(3373-3375)cGt>cTt	p.R1125L		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1125	Tyrosine-protein phosphatase.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GATTTTTGGCGTATGGTTTGG	0.338000													52	155					7.47603e-22	1.19422e-21	1	1	0
NPHP4	261734	broad.mit.edu	37	1	6008139	6008139	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:6008139G>T	ENST00000378156.4	-	8	1248	c.983C>A	c.(982-984)tCc>tAc	p.S328Y	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	328					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGGTCTTGGAAGAGGAGAC	0.557000													11	33					1.5842e-08	1.98833e-08	1	1	0
PRAMEF2	65122	broad.mit.edu	37	1	12919136	12919136	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:12919136A>T	ENST00000240189.2	+	2	359	c.272A>T	c.(271-273)cAg>cTg	p.Q91L		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	91										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCTTACACAGAAGGATCGC	0.552000													91	243					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230661362	230661362	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:230661362G>A	ENST00000283943.5	-	24	3714	c.3536C>T	c.(3535-3537)gCt>gTt	p.A1179V	TRIP12_ENST00000389044.4_Missense_Mutation_p.A1227V|TRIP12_ENST00000389045.3_Missense_Mutation_p.A909V	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1179					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TCTGCTCACAGCATCCTTTTC	0.348000													17	89					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161173236	161173236	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:161173236G>T	ENST00000392179.4	+	2	344	c.105G>T	c.(103-105)cgG>cgT	p.R35R	NDUFS2_ENST00000367993.3_Silent_p.R35R|NDUFS2_ENST00000476409.2_Intron	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	35					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	GAGGTGTTCGGCAGTGGCAGC	0.537000													15	59					6.31663e-08	7.69253e-08	1	1	0
ADCY2	108	broad.mit.edu	37	5	7757687	7757687	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:7757687C>T	ENST00000338316.4	+	16	2171	c.2082C>T	c.(2080-2082)gcC>gcT	p.A694A	ADCY2_ENST00000537121.1_Silent_p.A514A	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	694					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.?(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TAATGATGGCCGTGTTCAACA	0.547000													18	101					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053389	133053389	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:133053389T>A	ENST00000262283.5	-	9	1046	c.947A>T	c.(946-948)cAc>cTc	p.H316L	OC90_ENST00000603859.1_Missense_Mutation_p.H120L|OC90_ENST00000443356.2_Missense_Mutation_p.H120L|OC90_ENST00000254627.3_Missense_Mutation_p.H120L			Q02509	OC90_HUMAN	otoconin 90	120					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GCACCTGCGGTGCTGGAAGCA	0.562000													35	77					0	0	1	0	0
DEPDC7	91614	broad.mit.edu	37	11	33054483	33054483	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:33054483C>G	ENST00000311388.3	+	8	1661	c.1285C>G	c.(1285-1287)Cag>Gag	p.Q429E	DEPDC7_ENST00000241051.3_Missense_Mutation_p.Q438E	NM_139160.2	NP_631899.2	Q96QD5	DEPD7_HUMAN	DEP domain containing 7	438					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	17						TATGGCCATACAGAACGGAAG	0.323000													12	99					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75847172	75847172	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:75847172C>G	ENST00000322507.8	-	31	5684	c.5375G>C	c.(5374-5376)gGg>gCg	p.G1792A	COL12A1_ENST00000483888.2_Missense_Mutation_p.G1792A|COL12A1_ENST00000416123.2_Missense_Mutation_p.G1792A|COL12A1_ENST00000345356.6_Missense_Mutation_p.G628A	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1792	Fibronectin type-III 13.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ATTGCCTTCCCCTGTGGAAGG	0.388000													5	35					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57685482	57685482	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:57685482C>T	ENST00000562631.1	+	3	967	c.435C>T	c.(433-435)agC>agT	p.S145S	GPR56_ENST00000456916.1_Silent_p.S145S|GPR56_ENST00000388812.4_Silent_p.S145S|GPR56_ENST00000379694.4_Intron|GPR56_ENST00000568908.1_Silent_p.S145S|GPR56_ENST00000538815.1_Silent_p.S145S|GPR56_ENST00000568909.1_Silent_p.S145S|GPR56_ENST00000379696.3_Silent_p.S145S|GPR56_ENST00000564912.1_3'UTR|GPR56_ENST00000562558.1_Silent_p.S145S|GPR56_ENST00000544297.1_5'UTR|GPR56_ENST00000540164.2_Silent_p.S145S|GPR56_ENST00000567835.1_Silent_p.S145S|GPR56_ENST00000388813.5_Silent_p.S145S			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	145					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						CCTGGTGGAGCCCTCAGAACA	0.607000													6	46					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954809	70954809	+	Silent	SNP	C	C	T	rs76023477	by1000genomes	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:70954809C>T	ENST00000393567.2	-	46	7620	c.7470G>A	c.(7468-7470)gcG>gcA	p.A2490A		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2490										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GCTCATGGGGCGCTTCCTCCA	0.622000													7	46					0	0	1	0	0
MTDH	92140	broad.mit.edu	37	8	98735159	98735159	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:98735159C>T	ENST00000336273.3	+	11	1902	c.1574C>T	c.(1573-1575)tCa>tTa	p.S525L	MTDH_ENST00000519934.1_Missense_Mutation_p.S469L	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	525					lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			GTAATCTTATCAAAAAGTGAT	0.383000													44	129					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109278920	109278920	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:109278920C>A	ENST00000228476.3	+	2	342	c.138C>A	c.(136-138)gaC>gaA	p.D46E	DAO_ENST00000551281.1_Missense_Mutation_p.D46E	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	46					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						CCACCACCGACGTGGCTGCCG	0.627000													21	114					2.89027e-11	3.96472e-11	1	1	0
FAT2	2196	broad.mit.edu	37	5	150923131	150923131	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:150923131A>G	ENST00000261800.5	-	9	7569	c.7557T>C	c.(7555-7557)acT>acC	p.T2519T		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2519	Cadherin 22.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TATTGATGATAGTATAATCTA	0.418000													56	175					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10777427	10777427	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:10777427C>A	ENST00000075503.3	-	8	1269	c.749G>T	c.(748-750)gGg>gTg	p.G250V		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	250	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						TGCCACATCCCCATGGAACAA	0.478000										HNSCC(73;0.22)			28	168					4.87955e-14	6.9789e-14	1	1	0
TMEM119	338773	broad.mit.edu	37	12	108985414	108985414	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:108985414C>A	ENST00000392806.3	-	2	914	c.746G>T	c.(745-747)gGc>gTc	p.G249V		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	249						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CTCCCCTTGGCCCTCACCGGC	0.662000													37	121					4.0492e-12	5.6812e-12	1	1	0
FAM101A	144347	broad.mit.edu	37	12	124798961	124798961	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:124798961A>C	ENST00000389727.3	+	3	541	c.541A>C	c.(541-543)Acc>Ccc	p.T181P	FAM101A_ENST00000338359.4_Missense_Mutation_p.T100P|FAM101A_ENST00000546355.1_Missense_Mutation_p.T100P|FAM101A_ENST00000324038.3_Missense_Mutation_p.T100P			Q6ZTI6	F101A_HUMAN	family with sequence similarity 101, member A	181										endometrium(1)|kidney(1)|lung(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CACTTTCCGGACCACCCTGCA	0.701000													16	64					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11607714	11607714	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr17:11607714C>A	ENST00000262442.3	+	25	5414	c.5346C>A	c.(5344-5346)atC>atA	p.I1782I	DNAH9_ENST00000454412.2_Silent_p.I1782I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1782	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TATGCACCATCGATGTGCATG	0.498000													12	78					0.00136819	0.00147191	1	1	0
TPTE2	93492	broad.mit.edu	37	13	20041365	20041365	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr13:20041365C>A	ENST00000400230.2	-	7	556	c.512_splice	c.e7+1	p.R171_splice	TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382977.4_Splice_Site_p.R171_splice|TPTE2_ENST00000400103.2_Intron|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000382975.4_Intron|TPTE2_ENST00000382978.1_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	171						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TGTTTCATACCTGGGAATATT	0.294000													17	43					0.000566183	0.000616288	1	1	0
ZNF831	128611	broad.mit.edu	37	20	57767984	57767984	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr20:57767984C>T	ENST00000371030.2	+	1	1910	c.1910C>T	c.(1909-1911)gCc>gTc	p.A637V		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	637						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AAAATGAAAGCCAGTCCCCAT	0.567000													26	100					0	0	1	0	0
EGFL6	25975	broad.mit.edu	37	X	13635972	13635972	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:13635972C>G	ENST00000361306.1	+	8	1159	c.902C>G	c.(901-903)cCa>cGa	p.P301R	EGFL6_ENST00000380602.3_Missense_Mutation_p.P301R	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	301					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						AATGTTACCCCAGAACCCACC	0.448000													40	51					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108642027	108642027	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:108642027G>T	ENST00000332082.4	+	10	2423	c.1605G>T	c.(1603-1605)atG>atT	p.M535I	WSCD2_ENST00000547525.1_Missense_Mutation_p.M535I|WSCD2_ENST00000261400.3_Missense_Mutation_p.M555I|WSCD2_ENST00000549903.1_Missense_Mutation_p.M555I			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	535						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CTGCGGACATGCAGAAGACCA	0.572000													21	70					4.54149e-19	6.86807e-19	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77690591	77690591	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:77690591C>A	ENST00000521891.2	+	4	3689	c.3241C>A	c.(3241-3243)Cag>Aag	p.Q1081K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.Q1055K|ZFHX4_ENST00000517683.1_3'UTR|ZFHX4_ENST00000050961.6_Missense_Mutation_p.Q1055K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.Q1055K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1055						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACGGAAGCTCCAGCTCCACCA	0.512000										HNSCC(33;0.089)			43	184					1.8453e-21	2.89751e-21	1	1	0
OR6B1	135946	broad.mit.edu	37	7	143701237	143701237	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:143701237C>T	ENST00000408922.2	+	1	216	c.148C>T	c.(148-150)Ctg>Ttg	p.L50L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					CCTATTGGTGCTGCAAAATCG	0.488000													18	97					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72620755	72620755	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:72620755G>A	ENST00000273951.8	-	9	1447	c.1104C>T	c.(1102-1104)acC>acT	p.T368T	GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Silent_p.T387T|GC_ENST00000513476.1_Silent_p.T368T	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	368	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GGCTTTTTAGGGTTGGCTCAA	0.383000													17	75					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200946363	200946363	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:200946363G>T	ENST00000332129.2	-	30	4579	c.4263C>A	c.(4261-4263)gcC>gcA	p.A1421A	KIF21B_ENST00000360529.5_Silent_p.A1421A|KIF21B_ENST00000461742.2_Silent_p.A1434A|KIF21B_ENST00000422435.2_Silent_p.A1434A	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1434					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGATGCGGACGGCATTGCCCG	0.637000													36	122					2.75727e-19	4.18697e-19	1	1	0
RELN	5649	broad.mit.edu	37	7	103230058	103230058	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:103230058C>A	ENST00000424685.2	-	28	4289	c.4130G>T	c.(4129-4131)aGg>aTg	p.R1377M	RELN_ENST00000428762.1_Missense_Mutation_p.R1377M|RELN_ENST00000343529.5_Missense_Mutation_p.R1377M			P78509	RELN_HUMAN	reelin	1377					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGCAAGAGACCTTGGAATAAC	0.418000													32	197					8.88839e-20	1.36659e-19	1	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14822608	14822608	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:14822608C>A	ENST00000358984.4	+	26	2498	c.2318C>A	c.(2317-2319)aCc>aAc	p.T773N	RP11-1157N2__B.2_ENST00000581117.1_RNA	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	858										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ATTTAGCCTACCTGTGGAATG	0.259000													6	7					8.12818e-05	9.06133e-05	1	1	0
C3AR1	719	broad.mit.edu	37	12	8211736	8211736	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:8211736G>A	ENST00000307637.4	-	2	1249	c.1046C>T	c.(1045-1047)tCt>tTt	p.S349F		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	349					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		CATGATAACAGAGGGCAGCAG	0.498000													19	79					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	191861864	191861864	+	Silent	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:191861864A>T	ENST00000454309.2	-	5	1491	c.666T>A	c.(664-666)cgT>cgA	p.R222R	FGF12_ENST00000450716.1_Silent_p.R160R|FGF12_ENST00000264730.3_Silent_p.R160R|FGF12_ENST00000445105.1_Silent_p.R160R|FGF12_ENST00000430714.1_Silent_p.R123R	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	222					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTTTCCTTGAACGCCCTTGTT	0.398000													59	191					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147276	26147276	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:26147276C>A	ENST00000331351.5	+	2	1470	c.1078C>A	c.(1078-1080)Ctc>Atc	p.L360I	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	360					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		TGGTGAGCGACTCATTGTGGA	0.498000													11	140					2.80697e-09	3.60897e-09	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89448515	89448515	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:89448515T>A	ENST00000336596.2	+	7	1704	c.1479T>A	c.(1477-1479)aaT>aaA	p.N493K	EPHA3_ENST00000494014.1_Missense_Mutation_p.N493K|EPHA3_ENST00000452448.2_Missense_Mutation_p.N493K	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	493	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GAGGCACAAATGTTACCATCA	0.413000										TSP Lung(6;0.00050)			26	75					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383054	22383054	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:22383054G>A	ENST00000328795.4	+	1	673	c.582G>A	c.(580-582)gtG>gtA	p.V194V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ACATGTTTGTGGTGGAGCTTC	0.527000													33	153					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453703	58453703	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:58453703C>A	ENST00000282308.3	-	3	669	c.473G>T	c.(472-474)aGc>aTc	p.S158I	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	158					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		AAATGTGCAGCTGCTCAAAAA	0.458000													18	102					9.16793e-09	1.1546e-08	1	1	0
HCN1	348980	broad.mit.edu	37	5	45645613	45645613	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:45645613A>T	ENST00000303230.4	-	2	580	c.523T>A	c.(523-525)Tgg>Agg	p.W175R		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	175						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AAAATAATCCATGGTGTTGTT	0.358000													31	97					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184717	19184717	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:19184717C>A	ENST00000275461.3	-	1	327	c.269G>T	c.(268-270)gGc>gTc	p.G90V	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	90					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CTTGGGGCGGCCTAATAGGGA	0.597000													13	22					9.31168e-06	1.06378e-05	1	1	0
HMGXB4	10042	broad.mit.edu	37	22	35661239	35661239	+	Silent	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr22:35661239G>T	ENST00000216106.5	+	5	986	c.858G>T	c.(856-858)ggG>ggT	p.G286G	HMGXB4_ENST00000444518.2_Silent_p.G177G	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	286					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCTTTCAGGGCTTGAACCTA	0.498000													16	71					0.000422831	0.000461612	1	1	0
ITGAX	3687	broad.mit.edu	37	16	31373193	31373193	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:31373193A>T	ENST00000268296.4	+	10	1170	c.1049A>T	c.(1048-1050)gAg>gTg	p.E350V	ITGAX_ENST00000562522.1_Missense_Mutation_p.E350V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	350					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TTCGAATTGGAGATGGCACAG	0.622000													36	135					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64427875	64427875	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:64427875G>A	ENST00000265459.6	-	11	2779	c.2318C>T	c.(2317-2319)aCt>aTt	p.T773I	NRXN2_ENST00000409571.1_Missense_Mutation_p.T766I|NRXN2_ENST00000377551.1_Missense_Mutation_p.T773I|NRXN2_ENST00000377559.3_Missense_Mutation_p.T742I	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	773	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CTCCCTGGAAGTGGTGGCCAT	0.597000													24	57					0	0	1	0	0
SLC9A6	10479	broad.mit.edu	37	X	135106602	135106602	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:135106602G>T	ENST00000370695.4	+	12	1611	c.1576G>T	c.(1576-1578)Ggt>Tgt	p.G526C	SLC9A6_ENST00000370698.3_Missense_Mutation_p.G494C|SLC9A6_ENST00000370701.1_Missense_Mutation_p.G474C	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	494					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					GTGGGTATTTGGTGGTGGCAC	0.408000													36	57					1.00001e-27	1.70047e-27	1	1	0
OR51I2	390064	broad.mit.edu	37	11	5475624	5475624	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:5475624C>A	ENST00000341449.2	+	1	987	c.906C>A	c.(904-906)gcC>gcA	p.A302A	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCGCCGAGCCATTTTCCGCA	0.433000													26	171					3.28513e-13	4.66235e-13	1	1	0
TYR	7299	broad.mit.edu	37	11	88924525	88924525	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:88924525C>A	ENST00000263321.5	+	2	1477	c.975C>A	c.(973-975)acC>acA	p.T325T	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	325			T -> A (in OCA1B).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TGAGTTTGACCCAATATGAAT	0.418000													50	153					7.34454e-26	1.22631e-25	1	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84607902	84607902	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:84607902G>T	ENST00000344803.2	+	4	2564	c.2517G>T	c.(2515-2517)gaG>gaT	p.E839D		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AGAAATTTGAGGAAATCAATG	0.443000													21	108					4.35082e-09	5.57448e-09	1	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65334267	65334267	+	Silent	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:65334267G>A	ENST00000284037.5	+	15	1652	c.1263G>A	c.(1261-1263)gtG>gtA	p.V421V	ERBB2IP_ENST00000506030.1_Silent_p.V421V|ERBB2IP_ENST00000380938.2_Silent_p.V421V|ERBB2IP_ENST00000380939.2_Silent_p.V421V|ERBB2IP_ENST00000380935.1_Silent_p.V421V|ERBB2IP_ENST00000508515.1_Silent_p.V421V|ERBB2IP_ENST00000380936.1_Silent_p.V421V|ERBB2IP_ENST00000380943.2_Silent_p.V421V|ERBB2IP_ENST00000511297.1_Silent_p.V421V|ERBB2IP_ENST00000416865.2_Intron	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	421					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGAAAATGGTGCTTACCAACT	0.358000													27	96					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805230	54805230	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:54805230C>A	ENST00000306858.7	+	5	1577	c.1461C>A	c.(1459-1461)acC>acA	p.T487T		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	487										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTGAACATACCACAAAGTCAT	0.408000													44	128					4.10826e-27	6.95389e-27	1	1	0
PSG5	5673	broad.mit.edu	37	19	43680055	43680055	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:43680055T>G	ENST00000404580.1	-	3	764	c.676A>C	c.(676-678)Atg>Ctg	p.M226L	PSG5_ENST00000599812.1_Missense_Mutation_p.M319L|PSG5_ENST00000366175.3_Missense_Mutation_p.M226L|PSG5_ENST00000342951.6_Missense_Mutation_p.M226L|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000407356.1_Missense_Mutation_p.M226L			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	226	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TCACTGCGCATGCCACCATCT	0.493000													43	209					0	0	1	0	0
C12orf66	144577	broad.mit.edu	37	12	64588290	64588290	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:64588290G>A	ENST00000311915.8	-	3	697	c.670C>T	c.(670-672)Cag>Tag	p.Q224*	C12orf66_ENST00000398055.3_Nonsense_Mutation_p.Q224*|C12orf66_ENST00000544871.1_Nonsense_Mutation_p.Q171*			Q96MD2	CL066_HUMAN	chromosome 12 open reading frame 66	224										central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)	5						CCCCACGTCTGCAGTTTGGTG	0.532000													13	69					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161967618	161967618	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:161967618T>C	ENST00000294794.3	-	6	1894	c.1471A>G	c.(1471-1473)Ata>Gta	p.I491V	OLFML2B_ENST00000367940.2_Missense_Mutation_p.I492V	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	491										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			AACTTACCTATGACATTCCGG	0.547000													42	416					0	0	1	0	0
GUCA1A	2978	broad.mit.edu	37	6	42146129	42146129	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:42146129G>A	ENST00000394237.1	+	4	1289	c.313G>A	c.(313-315)Ggc>Agc	p.G105S	GUCA1A_ENST00000053469.4_Missense_Mutation_p.G105S|GUCA1A_ENST00000372958.1_Missense_Mutation_p.G105S|GUCA1A_ENST00000541991.1_Missense_Mutation_p.G105S			P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	105	EF-hand 3.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	7	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGATGGCAACGGCTGCATTGA	0.607000													18	134					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75806981	75806981	+	Silent	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:75806981T>C	ENST00000322507.8	-	59	8874	c.8565A>G	c.(8563-8565)ccA>ccG	p.P2855P	COL12A1_ENST00000511023.1_5'UTR|COL12A1_ENST00000483888.2_Silent_p.P2855P|COL12A1_ENST00000416123.2_Silent_p.P2779P|COL12A1_ENST00000345356.6_Silent_p.P1691P	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2855	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GCGGCCCTGGTGGGCCCCTGG	0.468000													16	67					0	0	1	0	0
MPPED2	744	broad.mit.edu	37	11	30601896	30601896	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:30601896C>A	ENST00000448418.2	-	2	385	c.25G>T	c.(25-27)Ggc>Tgc	p.G9C	MPPED2_ENST00000358117.5_Missense_Mutation_p.G9C	NM_001145399.1	NP_001138871.1	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	9					nervous system development		hydrolase activity|metal ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(15)|skin(2)|upper_aerodigestive_tract(2)	33						GTAACTTTGCCTTGAGAAGGA	0.493000													13	87					0.00136819	0.00147191	1	1	0
MCM4	4173	broad.mit.edu	37	8	48874637	48874637	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:48874637G>T	ENST00000262105.2	+	3	469	c.260G>T	c.(259-261)aGt>aTt	p.S87I	MCM4_ENST00000523944.1_Missense_Mutation_p.S87I	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	87					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TTTGATGTTAGTTCACCACTG	0.468000													13	89					4.36969e-10	5.77927e-10	1	1	0
ADCY8	114	broad.mit.edu	37	8	131955652	131955652	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr8:131955652T>A	ENST00000286355.5	-	4	3390	c.1298A>T	c.(1297-1299)cAg>cTg	p.Q433L	RP11-737F9.1_ENST00000523318.1_RNA|ADCY8_ENST00000377928.3_Missense_Mutation_p.Q433L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	433					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GACCAGCTCCTGAGCAGACAA	0.483000										HNSCC(32;0.087)			13	63					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145537026	145537026	+	Silent	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:145537026T>A	ENST00000394434.2	-	10	1171	c.1005A>T	c.(1003-1005)tcA>tcT	p.S335S	LARS_ENST00000511505.1_5'UTR|LARS_ENST00000545646.1_Silent_p.S289S|LARS_ENST00000510191.1_Silent_p.S281S|LARS_ENST00000274562.9_Silent_p.S308S	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	335	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	AGCCCTGGTATGACATATTCC	0.393000													19	99					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10597491	10597491	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:10597491C>T	ENST00000171111.5	-	6	2259	c.1712G>A	c.(1711-1713)gGc>gAc	p.G571D	KEAP1_ENST00000393623.2_Missense_Mutation_p.G571D	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACCATCATAGCCTCCTGCGGG	0.562000													14	47					0	0	1	0	0
EEF1E1	9521	broad.mit.edu	37	6	8080245	8080245	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:8080245C>G	ENST00000379715.5	-	4	459	c.403G>C	c.(403-405)Gaa>Caa	p.E135Q	EEF1E1-MUTED_ENST00000397456.2_Intron|EEF1E1_ENST00000429723.2_Intron	NM_004280.4	NP_004271.1	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1 epsilon 1	135	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus				endometrium(1)|prostate(1)	2	Ovarian(93;0.0398)					TTCTCCTTTTCTTGAACTGTC	0.373000													29	116					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48415121	48415121	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:48415121A>G	ENST00000296438.5	+	4	398	c.212A>G	c.(211-213)cAt>cGt	p.H71R	FBXW12_ENST00000415155.1_Missense_Mutation_p.H71R|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000445170.1_Missense_Mutation_p.H52R	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	71										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTTTTCCTGCATCAAAGAAGG	0.468000													25	87					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121881901	121881901	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:121881901C>G	ENST00000377069.4	-	16	2678	c.2272G>C	c.(2272-2274)Ggc>Cgc	p.G758R	KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.G789R|KDM2B_ENST00000542973.1_Missense_Mutation_p.G157R	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	789					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CGCAGAAGGCCGTCCGGCGGC	0.632000											OREG0022201	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	128					0	0	1	0	0
RCBTB2	1102	broad.mit.edu	37	13	49086961	49086961	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr13:49086961T>G	ENST00000344532.3	-	7	843	c.420A>C	c.(418-420)ttA>ttC	p.L140F	RCBTB2_ENST00000430805.2_Missense_Mutation_p.L145F|RCBTB2_ENST00000481144.1_5'UTR|RCBTB2_ENST00000544904.1_Missense_Mutation_p.L116F|RCBTB2_ENST00000544492.1_Intron	NM_001268.2	NP_001259.1	O95199	RCBT2_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	140							Ran guanyl-nucleotide exchange factor activity			breast(5)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(3)	31		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		GACAGGGCACTAAACCATGAT	0.403000													8	107					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73849914	73849914	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:73849914G>A	ENST00000334126.7	-	5	1032	c.806C>T	c.(805-807)tCt>tTt	p.S269F	C2CD3_ENST00000539061.1_Missense_Mutation_p.S269F|C2CD3_ENST00000313663.7_Missense_Mutation_p.S269F			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	269						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CAGAGTTACAGACTCTAAACT	0.443000													6	93					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327394	52327394	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:52327394C>A	ENST00000339223.4	+	2	572	c.393C>A	c.(391-393)gcC>gcA	p.A131A	FPR3_ENST00000595991.1_Silent_p.A131A	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	131					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TGCATCCAGCCTGGGCCCAGA	0.473000													11	99					1.58986e-06	1.86834e-06	1	1	0
TLR6	10333	broad.mit.edu	37	4	38830296	38830296	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:38830296C>A	ENST00000436693.2	-	2	918	c.799G>T	c.(799-801)Gtc>Ttc	p.V267F	TLR6_ENST00000381950.1_Missense_Mutation_p.V267F	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	267					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAGACTCTGACCAGGCATTTC	0.338000													11	62					0.11911	0.122087	1	1	0
RIC8A	60626	broad.mit.edu	37	11	209578	209578	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:209578G>C	ENST00000526104.1	+	3	1648	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	RIC8A_ENST00000527696.1_Missense_Mutation_p.E96Q|RIC8A_ENST00000325207.5_Missense_Mutation_p.E102Q			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	102						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTGTCTCTGAGGGGTCCGT	0.617000													6	56					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854201	40854201	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr5:40854201G>C	ENST00000254691.5	+	3	2966	c.2767G>C	c.(2767-2769)Ggg>Cgg	p.G923R	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	923					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						GACACAAGGTGGGGCTTCAAA	0.502000													14	179					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15197534	15197534	+	Silent	SNP	C	C	A	rs141502743	by1000genomes	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:15197534C>A	ENST00000379554.3	+	3	491	c.445C>A	c.(445-447)Cgg>Agg	p.R149R	INSC_ENST00000525218.1_Silent_p.R102R|INSC_ENST00000528567.1_Silent_p.R102R|INSC_ENST00000379556.3_Silent_p.R102R|INSC_ENST00000530161.1_Silent_p.R102R|INSC_ENST00000424273.1_Silent_p.R102R	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	149					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						CCGCTGGGCACGGGTGCACAG	0.632000													3	19					6.4e-05	7.15636e-05	1	1	0
OR51G1	79324	broad.mit.edu	37	11	4944834	4944834	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:4944834G>T	ENST00000321961.2	-	1	803	c.736C>A	c.(736-738)Cat>Aat	p.H246N	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCACAGATATGAGAGACACAG	0.542000													24	93					2.89027e-11	3.96472e-11	1	1	0
WNT3A	89780	broad.mit.edu	37	1	228210487	228210487	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:228210487C>A	ENST00000284523.1	+	2	269	c.191C>A	c.(190-192)cCc>cAc	p.P64H	WNT3A_ENST00000366753.2_Missense_Mutation_p.P64H	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	64					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				GAGATCATGCCCAGCGTGGCC	0.652000													16	72					3.52763e-06	4.0678e-06	1	1	0
NRDE2	55051	broad.mit.edu	37	14	90782961	90782961	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr14:90782961C>A	ENST00000354366.3	-	3	600	c.368G>T	c.(367-369)aGa>aTa	p.R123I	NRDE2_ENST00000357904.3_Intron|NRDE2_ENST00000557106.1_5'UTR	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		TCCAACGCCTCTGGAAGGTTT	0.448000													72	259					4.03997e-35	7.09881e-35	1	1	0
KLHL1	57626	broad.mit.edu	37	13	70681368	70681368	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr13:70681368G>T	ENST00000377844.4	-	1	1223	c.464C>A	c.(463-465)tCt>tAt	p.S155Y	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_Missense_Mutation_p.S23Y	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	155					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TGCCTGGCTAGAGTTGTCTGG	0.542000													43	127					2.56175e-15	3.75113e-15	1	1	0
EPB41L3	23136	broad.mit.edu	37	18	5398034	5398034	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr18:5398034G>A	ENST00000341928.2	-	17	2798	c.2458C>T	c.(2458-2460)Caa>Taa	p.Q820*	EPB41L3_ENST00000342933.3_Nonsense_Mutation_p.Q820*|EPB41L3_ENST00000400111.3_Intron|EPB41L3_ENST00000544123.1_Nonsense_Mutation_p.Q651*|EPB41L3_ENST00000542652.2_Intron|EPB41L3_ENST00000542146.1_Nonsense_Mutation_p.Q125*|EPB41L3_ENST00000427684.2_Nonsense_Mutation_p.Q117*|EPB41L3_ENST00000540638.2_Intron	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	820	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity	p.Q820E(1)		breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						ACCCAGCTTTGAGAAGTAGAA	0.463000													31	230					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212587160	212587160	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:212587160C>A	ENST00000342788.4	-	7	1151	c.841G>T	c.(841-843)Gca>Tca	p.A281S	ERBB4_ENST00000402597.1_Missense_Mutation_p.A281S|ERBB4_ENST00000436443.1_Missense_Mutation_p.A281S	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	281	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTGTACTTTGCATTGAAATTG	0.373000										TSP Lung(8;0.080)			14	56					1.3612e-06	1.60988e-06	1	1	0
PASK	23178	broad.mit.edu	37	2	242066565	242066565	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:242066565C>A	ENST00000403638.3	-	10	1856	c.1765G>T	c.(1765-1767)Ggg>Tgg	p.G589W	PASK_ENST00000544142.1_Missense_Mutation_p.G403W|PASK_ENST00000539818.1_Missense_Mutation_p.G373W|PASK_ENST00000358649.4_Missense_Mutation_p.G589W|PASK_ENST00000234040.4_Missense_Mutation_p.G589W|PASK_ENST00000405260.1_Missense_Mutation_p.G589W	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	589					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		ACGGCAGCCCCAGCCCAAAGG	0.652000													11	84					0.00829132	0.00876647	1	1	0
OR2J2	26707	broad.mit.edu	37	6	29141463	29141463	+	Silent	SNP	A	A	G			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:29141463A>G	ENST00000377167.2	+	1	153	c.51A>G	c.(49-51)ggA>ggG	p.G17G		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TTCTACTTGGATTTTCTAATT	0.353000													10	214					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:25398284C>G	ENST00000311936.3	-	2	226	c.35G>C	c.(34-36)gGt>gCt	p.G12A	KRAS_ENST00000256078.4_Missense_Mutation_p.G12A|KRAS_ENST00000557334.1_Missense_Mutation_p.G12A|KRAS_ENST00000556131.1_Missense_Mutation_p.G12A	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			11	40					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51957991	51957991	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:51957991C>A	ENST00000321424.3	-	5	1161	c.1095G>T	c.(1093-1095)ggG>ggT	p.G365G	SIGLEC8_ENST00000340550.5_Silent_p.G272G|SIGLEC8_ENST00000430817.1_Silent_p.G256G	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	365					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCCAGCTCCCCCGACTGCTG	0.562000													17	89					6.94344e-10	9.15047e-10	1	1	0
MYO5A	4644	broad.mit.edu	37	15	52672056	52672056	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:52672056C>A	ENST00000399231.3	-	17	2305	c.2062G>T	c.(2062-2064)Gaa>Taa	p.E688*	MYO5A_ENST00000399233.2_Nonsense_Mutation_p.E688*|MYO5A_ENST00000356338.6_Nonsense_Mutation_p.E688*|MYO5A_ENST00000553916.1_Nonsense_Mutation_p.E688*|MYO5A_ENST00000358212.6_Nonsense_Mutation_p.E688*	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	688	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CGGATGGTTTCCAGGACACCA	0.488000													47	79					1.67211e-32	2.92421e-32	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186113753	186113753	+	Silent	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:186113753C>T	ENST00000271588.4	+	91	14413	c.14184C>T	c.(14182-14184)tcC>tcT	p.S4728S	HMCN1_ENST00000367492.2_Silent_p.S4728S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4728	TSP type-1 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGGGCTGCTCCGACCCTGTGC	0.537000													12	206					0	0	1	0	0
C6orf203	51250	broad.mit.edu	37	6	107361034	107361034	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:107361034G>T	ENST00000443043.1	+	3	760	c.85G>T	c.(85-87)Ggt>Tgt	p.G29C	C6orf203_ENST00000405204.2_Missense_Mutation_p.G24C|C6orf203_ENST00000311381.5_Missense_Mutation_p.G24C	NM_001142470.1	NP_001135942.1	Q9P0P8	CF203_HUMAN	chromosome 6 open reading frame 203	24										large_intestine(4)|lung(2)|prostate(1)|urinary_tract(1)	8	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		TGGACTCTGGGGTGTTCTCCG	0.408000													29	91					1.7881e-09	2.30703e-09	1	1	0
MPEG1	219972	broad.mit.edu	37	11	58978579	58978579	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:58978579G>T	ENST00000361050.3	-	1	1845	c.1760C>A	c.(1759-1761)tCc>tAc	p.S587Y		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	587						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				AGGGGGCAGGGACCCTCCTGT	0.592000													21	170					1.28384e-07	1.54312e-07	1	1	0
PLG	5340	broad.mit.edu	37	6	161134115	161134115	+	Missense_Mutation	SNP	C	C	A	rs143256245	byFrequency	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:161134115C>A	ENST00000308192.9	+	5	568	c.505C>A	c.(505-507)Cca>Aca	p.P169T	PLG_ENST00000462918.1_3'UTR	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	169	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TACTACTGATCCAGAAAAGAG	0.468000													22	167					3.28513e-13	4.66235e-13	1	1	0
P2RY10	27334	broad.mit.edu	37	X	78216671	78216671	+	Silent	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:78216671C>A	ENST00000171757.2	+	4	934	c.654C>A	c.(652-654)acC>acA	p.T218T	P2RY10_ENST00000544091.1_Silent_p.T218T	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	218						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CATGGTGTACCTGGAAAACTA	0.478000													37	31					2.87052e-16	4.23689e-16	1	1	0
KLHL34	257240	broad.mit.edu	37	X	21674670	21674670	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chrX:21674670C>A	ENST00000379499.2	-	1	1778	c.1237G>T	c.(1237-1239)Gaa>Taa	p.E413*		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	413										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						GCCCGCGCTTCCCGCATGGCG	0.716000													5	2					0.014758	0.0152969	1	1	0
GIMAP6	474344	broad.mit.edu	37	7	150325274	150325274	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:150325274C>T	ENST00000328902.5	-	3	628	c.412G>A	c.(412-414)Gag>Aag	p.E138K	GIMAP6_ENST00000493969.1_Silent_p.*63*	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	138							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCTGATCCTCATCCGTGAAC	0.642000													34	94					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88367508	88367508	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:88367508T>A	ENST00000419482.2	+	1	210	c.125T>A	c.(124-126)gTg>gAg	p.V42E	SMYD1_ENST00000444564.2_Missense_Mutation_p.V42E|SMYD1_ENST00000438570.1_Missense_Mutation_p.V42E	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	42					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						TATTCCGCAGTGGTTTTTGAC	0.502000													22	134					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71974078	71974078	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:71974078C>A	ENST00000266674.5	+	16	1738	c.1427C>A	c.(1426-1428)gCt>gAt	p.A476D	LGR5_ENST00000540815.2_Missense_Mutation_p.A452D|LGR5_ENST00000536515.1_Missense_Mutation_p.A404D			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	476						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						ATGCCTTATGCTTACCAGTGC	0.343000													64	202					5.45122e-27	9.18494e-27	1	1	0
RBMXL2	27288	broad.mit.edu	37	11	7111281	7111281	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:7111281G>T	ENST00000306904.5	+	1	1117	c.930G>T	c.(928-930)gaG>gaT	p.E310D		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	310	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTACGAGGAGTACCGGGGCT	0.687000													7	28					2.17888e-05	2.45873e-05	1	1	0
C3orf58	205428	broad.mit.edu	37	3	143704407	143704407	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:143704407G>T	ENST00000315691.3	+	2	1215	c.680G>T	c.(679-681)tGg>tTg	p.W227L	C3orf58_ENST00000495414.1_Missense_Mutation_p.W18L|C3orf58_ENST00000441925.2_5'UTR|C3orf58_ENST00000493396.1_Intron	NM_173552.3	NP_775823.1	Q8NDZ4	CC058_HUMAN	chromosome 3 open reading frame 58	227						COPI vesicle coat|extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GATGAAGGTTGGCCATTTGCA	0.378000													28	155					6.07407e-21	9.41737e-21	1	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68673583	68673583	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr11:68673583G>T	ENST00000255078.3	+	2	244	c.133G>T	c.(133-135)Gtg>Ttg	p.V45L	IGHMBP2_ENST00000539224.1_Missense_Mutation_p.V45L	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	45					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GAGCCGAGGCGTGTGTTTGCT	0.567000													30	96					3.65163e-15	5.30492e-15	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	47846497	47846497	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr6:47846497T>C	ENST00000339488.4	-	3	2116	c.2083A>G	c.(2083-2085)Att>Gtt	p.I695V		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	695						integral to membrane	hedgehog receptor activity										CCCAGCTCAATTGAGGTGACG	0.448000													18	51					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93299218	93299221	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr1:93299218_93299221delGTAA	ENST00000370321.3	+	3	279		c.e3+1			NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CATTTGTCAGGTAAGTTGTATTCT	0.397													16	47	---	---	---	---					
ATL2	64225	broad.mit.edu	37	2	38525341	38525353	+	Frame_Shift_Del	DEL	TCCCCAGAGTATT	TCCCCAGAGTATT	-	rs143133196	by1000genomes	TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr2:38525341_38525353delTCCCCAGAGTATT	ENST00000378954.4	-	12	1566_1578	c.1565_1577delAATACTCTGGGGA	c.(1564-1578)agfs	p.KYSGE522fs	ATL2_ENST00000539122.1_Frame_Shift_Del_p.KYSGE351fs|ATL2_ENST00000546051.1_Frame_Shift_Del_p.KYSGE351fs|ATL2_ENST00000406122.1_Frame_Shift_Del_p.KYSGE351fs|ATL2_ENST00000419554.2_Frame_Shift_Del_p.KYSGE522fs|ATL2_ENST00000402054.1_Frame_Shift_Del_p.KYSGE351fs|ATL2_ENST00000452935.2_Frame_Shift_Del_p.KYSGE504fs|ATL2_ENST00000332337.4_Frame_Shift_Del_p.KYSGE504fs	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	522					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						TTCTCTGAACTCCCCAGAGTATTTAACATATGC	0.390													9	116	---	---	---	---					
SLC33A1	9197	broad.mit.edu	37	3	155571742	155571742	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr3:155571742delC	ENST00000392845.2	-	1	425	c.45delG	c.(43-45)cgfs	p.R15fs	SLC33A1_ENST00000359479.3_Frame_Shift_Del_p.R15fs	NM_004733.3	NP_004724.1	O00400	ACATN_HUMAN	solute carrier family 33 (acetyl-CoA transporter), member 1	15					cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	22			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AATTCCCTGGCCGCCGTTGCC	0.617													7	42	---	---	---	---					
CWH43	80157	broad.mit.edu	37	4	48996685	48996685	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:48996685delG	ENST00000226432.4	+	5	744	c.561delG	c.(559-561)acfs	p.T187fs	CWH43_ENST00000513409.1_Frame_Shift_Del_p.T160fs	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	187					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						AGGTAGCCACGGGGATGGCCT	0.443													31	130	---	---	---	---					
SRP72	6731	broad.mit.edu	37	4	57333827	57333836	+	Frame_Shift_Del	DEL	TGTCAGTACC	TGTCAGTACC	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr4:57333827_57333836delTGTCAGTACC	ENST00000342756.5	+	1	747_756	c.26_35delTGTCAGTACC	c.(25-36)gtfs	p.VSVP9fs	SRP72_ENST00000510663.1_Frame_Shift_Del_p.VSVP9fs|SRP72_ENST00000504757.1_Frame_Shift_Del_p.VSVP9fs	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	9					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					AGCGGGGGGGTGTCAGTACCTGCGCTGTGG	0.657													7	28	---	---	---	---					
CCT6P1	643253	broad.mit.edu	37	7	65226819	65226819	+	RNA	DEL	A	A	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr7:65226819delA	ENST00000442266.1	+	0	1167																											AATGGGGACCAAAAAAAAAAT	0.353													2	4	---	---	---	---					
TAF1L	138474	broad.mit.edu	37	9	32635575	32635575	+	Translation_Start_Site	DEL	C	C	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr9:32635575delC	ENST00000242310.4	-	0	92				RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like						male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGCCGGGTCGCATAAACCGGA	0.572													22	46	---	---	---	---					
VWA2	340706	broad.mit.edu	37	10	116032616	116032616	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr10:116032616delG	ENST00000603594.1	+	6	810	c.489delG	c.(487-489)cafs	p.Q163fs	VWA2_ENST00000392982.3_Frame_Shift_Del_p.Q163fs	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	163	VWFA 1.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GGAAGTCCCAGGGGGATGTGG	0.557													20	55	---	---	---	---					
ACSS3	79611	broad.mit.edu	37	12	81532956	81532956	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr12:81532956delG	ENST00000548058.1	+	4	1602	c.692delG	c.(691-693)agfs	p.R231fs	ACSS3_ENST00000261206.3_Frame_Shift_Del_p.R230fs			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	231						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCTGGAAGGAGGGTAGAGTAC	0.348													14	79	---	---	---	---					
ADAM10	102	broad.mit.edu	37	15	58919977	58919978	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr15:58919977_58919978insA	ENST00000260408.3	-	10	1724_1725	c.1281_1282insT	c.(1279-1284)ctacaafs	p.Q428fs	ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Frame_Shift_Ins_p.Q127fs	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	428	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TTATTGTTGTTAAGTTTGTCCC	0.347													18	73	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													7	372	---	---	---	---					
SLC6A10P	386757	broad.mit.edu	37	16	32893251	32893251	+	RNA	DEL	C	C	-			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr16:32893251delC	ENST00000330048.5	-	0	1563					NR_003083.2																						GAGCCACCCTCCCCCCTGCAT	0.597													2	4	---	---	---	---					
LILRB4	11006	broad.mit.edu	37	19	55175253	55175254	+	Frame_Shift_Ins	INS	-	-	T			TCGA-NJ-A55R-01A-11D-A25L-08	TCGA-NJ-A55R-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9B923607-B58E-4215-9906-8CFA6301B887	212989CB-BF24-4B7B-AF52-BBBC977FA035	g.chr19:55175253_55175254insT	ENST00000391736.1	+	5	427_428	c.112_113insT	c.(112-114)gatfs	p.D38fs	LILRB4_ENST00000391734.3_Frame_Shift_Ins_p.D38fs|LILRB4_ENST00000430952.2_Frame_Shift_Ins_p.D38fs|LILRB4_ENST00000270452.2_Frame_Shift_Ins_p.D38fs|LILRB4_ENST00000391733.3_Frame_Shift_Ins_p.D38fs	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	38	Ig-like C2-type 1.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GCCAGGCTCTGTGATCAGCTGG	0.604													30	100	---	---	---	---					
