Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
SIGIRR	59307	broad.mit.edu	37	11	406437	406439	+	In_Frame_Del	DEL	GTC	GTC	-			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			GTC	-	GTC	GTC		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr11:406437_406439delGTC	ENST00000431843.2	-	9	1285_1287	c.979_981delGAC	c.(979-981)gacdel	p.D327del	SIGIRR_ENST00000332725.3_In_Frame_Del_p.D327del|SIGIRR_ENST00000529486.1_5'Flank|SIGIRR_ENST00000382520.2_In_Frame_Del_p.D327del|SIGIRR_ENST00000531205.1_In_Frame_Del_p.D327del|SIGIRR_ENST00000397632.3_In_Frame_Del_p.D327del	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain			13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)			TGGGGTCCTTGTCGTCCTGCAGC	0.650000																								0							SO:0001651	inframe_deletion			ENST00000431843.2	1	1	hg19	CCDS31325.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	SIGIRR-004	KNOWN	alternative_5_UTR|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000383884.3	1	0	0	125	457	0	73	1	1	135	429	0	73	2	0	0	0	0	0	0		1	1.000000	152	486	0	70	2								-20.000000	1	0	0	0		1	1	2	3	2.104286	0	0.670000	1.870000	0.671102	0.630000	5.400000e-01	0.750000	0.640000	0.645653	0.630000	0	5.800000e-01	7.000000e-01
FAT4	79633	broad.mit.edu	37	4	126241496	126241502	+	Frame_Shift_Del	DEL	CAATACC	CAATACC	-			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr4:126241496_126241502delCAATACC	ENST00000394329.3	+	1	3943_3949	c.3930_3936delCAATACC	c.(3928-3936)gacaataccfs	p.DNT1310fs		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	p.T1312S(2)		355					ATGAAAATGACAATACCCCTTCTTTCC	0.391000																								2	Substitution - Missense(2)						SO:0001589	frameshift_variant			ENST00000394329.3	1	1	hg19	CCDS3732.3																																																																																				TCGA-F2-6879-01A-11D-2154-08	FAT4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256765.2	1	0	0	100	512	0	80	0	1.925968e-01	0	5	0	80	2	0	0	0	0	0	0		1	1.000000	136	545	0	78	2								-20.000000	1	1	0	0		1	1	2	3	2.128560	0	0.670000	1.870000	0.672196	0.480000	4.000000e-01	0.600000	0.490000	0.498883	0.480000	0	4.400000e-01	5.400000e-01
NPAS4	266743	broad.mit.edu	37	11	66190209	66190209	+	Missense_Mutation	SNP	A	A	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr11:66190209A>T	ENST00000311034.2	+	4	671	c.495A>T	c.(493-495)aaA>aaT	p.K165N		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4			49					CAGGCAACAAACTCGTGCTTA	0.552000																								0							SO:0001583	missense			ENST00000311034.2	1	1	hg19	CCDS8138.1	.	.	.	.	.	.	.	.	.	.	A	22.2	4.254963	0.80135	.	.	ENSG00000174576	ENST00000311034	T	0.55588	0.51	5.74	1.2	0.21068	.	0.097095	0.45606	D	0.000357	T	0.70245	0.3202	M	0.87038	2.855	0.58432	D	0.999999	D	0.71674	0.998	D	0.72982	0.979	T	0.69461	-0.5139	10	0.87932	D	0	-10.5374	7.7832	0.29077	0.4889:0.0:0.5111:0.0	.	165	Q8IUM7	NPAS4_HUMAN	N	165	ENSP00000311196:K165N	ENSP00000311196:K165N	K	+	3	2	NPAS4	65946785	1.000000	0.71417	1.000000	0.80357	0.984000	0.73092	1.957000	0.40392	0.145000	0.18977	0.533000	0.62120	AAA		TCGA-F2-6879-01A-11D-2154-08	NPAS4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000392634.1	1	0	1	161	323	0	45		0	0	0	0	45	2		0	0	0	0	0	2	1	1.000000	160	315	0	45	2								-20.000000	1	1	0	0		1	1	2	3	2.152666	0	0.670000	1.870000	0.675436	0.990000	8.800000e-01	1.000000	1.000000	0.979802	0.990000	1	9.400000e-01	1
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr12:25398284C>A	ENST00000256078.4	-	2	98	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	1	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	27.2	4.808637	0.90707	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78707	-1.2;-1.2;-1.2;-1.2	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.90373	0.6987	M	0.90650	3.135	0.80722	D	1	D;D	0.76494	0.997;0.999	D;D	0.72625	0.969;0.978	D	0.91773	0.5429	10	0.72032	D	0.01	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	V	12	ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V	ENSP00000256078:G12V	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-F2-6879-01A-11D-2154-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	1	43	52	0	21	1	1	29	17	0	21	2	1	1	146	211	0	273	2	1	1.000000	42	52	0	20	2								-20.000000	1	1	0	0		1						0.670000	1.870000									0	0
HTR2A	3356	broad.mit.edu	37	13	47466615	47466615	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr13:47466615C>T	ENST00000378688.4	-	2	654	c.523G>A	c.(523-525)Gtc>Atc	p.V175I	HTR2A_ENST00000543956.1_Missense_Mutation_p.V91I|HTR2A_ENST00000542664.1_Missense_Mutation_p.V175I			P28223	5HT2A_HUMAN	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled			36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		Acepromazine(DB01614)|Amisulpride(DB06288)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Asenapine(DB06216)|Bromocriptine(DB01200)|Cabergoline(DB00248)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinitapride(DB08810)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Donepezil(DB00843)|Doxepin(DB01142)|Epinastine(DB00751)|Ergoloid mesylate(DB01049)|Ergotamine(DB00696)|Flupentixol(DB00875)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Iloperidone(DB04946)|Imipramine(DB00458)|Ketamine(DB01221)|Lisuride(DB00589)|Loxapine(DB00408)|Lurasidone(DB08815)|Maprotiline(DB00934)|Mesoridazine(DB00933)|Methotrimeprazine(DB01403)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Molindone(DB01618)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Pergolide(DB01186)|Pipotiazine(DB01621)|Pramipexole(DB00413)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Thioproperazine(DB01622)|Thioridazine(DB00679)|Thiothixene(DB01623)|Trazodone(DB00656)|Trimipramine(DB00726)|Yohimbine(DB01392)|Ziprasidone(DB00246)	TGGATGGCGACGTAGCGGTCC	0.537000																								0							SO:0001583	missense			ENST00000378688.4	1	1	hg19	CCDS9405.1	.	.	.	.	.	.	.	.	.	.	C	9.123	1.009491	0.19277	.	.	ENSG00000102468	ENST00000378688;ENST00000543956;ENST00000542664	T;T;T	0.38560	2.16;1.13;2.16	6.16	5.22	0.72569	GPCR, rhodopsin-like superfamily (1);	0.056991	0.64402	D	0.000002	T	0.11965	0.0291	N	0.01242	-0.935	0.41185	D	0.986261	B;B	0.16603	0.013;0.018	B;B	0.19391	0.022;0.025	T	0.39623	-0.9605	10	0.02654	T	1	.	4.7372	0.12993	0.0:0.7455:0.0:0.2545	.	91;175	F5GWE8;P28223	.;5HT2A_HUMAN	I	175;91;175	ENSP00000367959:V175I;ENSP00000441861:V91I;ENSP00000437737:V175I	ENSP00000367959:V175I	V	-	1	0	HTR2A	46364616	0.999000	0.42202	0.441000	0.26858	0.958000	0.62258	3.377000	0.52425	2.937000	0.99478	0.650000	0.86243	GTC		TCGA-F2-6879-01A-11D-2154-08	HTR2A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000044835.3	1	0	1	480	958	0	158		0	0	0	0	158	2		0	0	0	0	0	2	1	1.000000	475	941	0	155	2								-20.000000	1	1	121412	2	40	1	0	0	0	2.094656	0	0.670000	1.870000	0.670000	0.990000	9.100000e-01	1.000000	1.000000	0.983214	0.990000	1	9.500000e-01	1
NRXN3	9369	broad.mit.edu	37	14	79746678	79746678	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr14:79746678C>T	ENST00000557594.1	+	1	997	c.44C>T	c.(43-45)cCg>cTg	p.P15L	NRXN3_ENST00000281127.7_Missense_Mutation_p.P15L|NRXN3_ENST00000554719.1_Intron|NRXN3_ENST00000335750.5_Intron|NRXN3_ENST00000428277.2_Missense_Mutation_p.P15L	NM_001272020.1	NP_001258949.1	Q9HDB5	NRX3B_HUMAN	neurexin 3			104		Renal(4;0.00876)			CCTCGCCGGCCGGCCTGGACG	0.572000																								0							SO:0001583	missense			ENST00000557594.1	1	1	hg19		.	.	.	.	.	.	.	.	.	.	C	21.3	4.132572	0.77662	.	.	ENSG00000021645	ENST00000557594;ENST00000281127;ENST00000428277	T;T;T	0.35789	1.4;1.46;1.29	5.58	5.58	0.84498	.	.	.	.	.	T	0.43590	0.1254	N	0.14661	0.345	0.80722	D	1	D;D;D	0.89917	1.0;0.99;0.983	D;D;D	0.79108	0.992;0.969;0.931	T	0.33420	-0.9869	8	.	.	.	.	17.8182	0.88642	0.0:1.0:0.0:0.0	.	15;15;15	Q9HDB5-4;Q9HDB5-2;Q9HDB5	.;.;NRX3B_HUMAN	L	15	ENSP00000451672:P15L;ENSP00000281127:P15L;ENSP00000394426:P15L	.	P	+	2	0	NRXN3	78816431	1.000000	0.71417	1.000000	0.80357	0.995000	0.86356	2.259000	0.43259	2.647000	0.89833	0.558000	0.71614	CCG		TCGA-F2-6879-01A-11D-2154-08	NRXN3-004	NOVEL	basic	protein_coding	protein_coding	OTTHUMT00000413790.1	1	0	0	47	906	0	101	0	0	0	1	0	101	2		0	0	0	0	0	2	1	0.988252	44	889	1	99	28								-5.799979	1	1	0	0		1	1	2	3	2.137941	0	0.670000	1.870000	0.674364	0.140000	1.000000e-01	1.000000	0.150000	0.176379	0.140000	0	1.200000e-01	1.800000e-01
ACTC1	70	broad.mit.edu	37	15	35084689	35084689	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr15:35084689C>T	ENST00000290378.4	-	4	1191	c.536G>A	c.(535-537)cGt>cAt	p.R179H	RP11-814P5.1_ENST00000558707.1_RNA|ACTC1_ENST00000557860.1_5'UTR|RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1			31		all_lung(180;2.3e-08)			CAGATCCAGACGCATGATGGC	0.547000																								0							SO:0001583	missense			ENST00000290378.4	1	1	hg19	CCDS10041.1	.	.	.	.	.	.	.	.	.	.	C	16.59	3.167082	0.57476	.	.	ENSG00000159251	ENST00000290378;ENST00000544062	D	0.94966	-3.57	4.99	4.99	0.66335	.	0.000000	0.53938	U	0.000042	D	0.96225	0.8769	M	0.81682	2.555	0.80722	D	1	D	0.53462	0.96	P	0.52267	0.694	D	0.96705	0.9521	10	0.87932	D	0	.	18.8258	0.92117	0.0:1.0:0.0:0.0	.	179	P68032	ACTC_HUMAN	H	179;144	ENSP00000290378:R179H	ENSP00000290378:R179H	R	-	2	0	ACTC1	32871981	1.000000	0.71417	1.000000	0.80357	0.991000	0.79684	7.499000	0.81566	2.755000	0.94549	0.591000	0.81541	CGT		TCGA-F2-6879-01A-11D-2154-08	ACTC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000251876.3	1	0	1	112	343	0	78	0	1.537986e-01	0	3	0	78	2		0	0	0	0	0	2	1	1.000000	110	339	0	77	2								-20.000000	1	1	0	0		1	2	2	4	2.204492	0	0.670000	1.870000	0.686788	0.770000	6.500000e-01	1.000000	0.770000	0.791232	0.770000	0	7.100000e-01	8.600000e-01
NKD1	85407	broad.mit.edu	37	16	50666302	50666302	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr16:50666302C>T	ENST00000268459.3	+	9	1030	c.806C>T	c.(805-807)aCg>aTg	p.T269M		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)			23		all_cancers(37;0.229)			GAAAACTACACGTCCCAATTT	0.597000																								0							SO:0001583	missense			ENST00000268459.3	1	1	hg19	CCDS10743.1	.	.	.	.	.	.	.	.	.	.	C	27.0	4.791638	0.90367	.	.	ENSG00000140807	ENST00000268459	T	0.77620	-1.11	5.14	5.14	0.70334	.	0.000000	0.85682	D	0.000000	D	0.89273	0.6668	M	0.82823	2.61	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	D	0.90850	0.4730	10	0.87932	D	0	-12.9426	18.6084	0.91275	0.0:1.0:0.0:0.0	.	269	Q969G9	NKD1_HUMAN	M	269	ENSP00000268459:T269M	ENSP00000268459:T269M	T	+	2	0	NKD1	49223803	1.000000	0.71417	0.987000	0.45799	0.978000	0.69477	7.578000	0.82498	2.403000	0.81681	0.563000	0.77884	ACG		TCGA-F2-6879-01A-11D-2154-08	NKD1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256873.1	1	0	1	78	141	0	21	1	9.975721e-01	2	18	0	21	2		0	0	0	0	0	2	1	1.000000	77	138	0	19	2								-20.000000	1	1	121410	1	28	1	1	2	3	2.105498	0	0.670000	1.870000	0.671102	0.990000	8.700000e-01	1.000000	1.000000	0.986681	0.990000	1	9.600000e-01	1
FBXW10	10517	broad.mit.edu	37	17	18668178	18668178	+	Splice_Site	SNP	T	T	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr17:18668178T>C	ENST00000395665.4	+	8	1776		c.e8+2		FBXW10_ENST00000308799.4_Splice_Site|FBXW10_ENST00000301938.4_Splice_Site|FBXW10_ENST00000395667.1_Splice_Site			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10			42					AGGTAAAAGGTGAGAAAGAAG	0.443000																								0							SO:0001630	splice_region_variant			ENST00000395665.4	0	1	hg19	CCDS11199.3	.	.	.	.	.	.	.	.	.	.	T	12.17	1.856478	0.32791	.	.	ENSG00000171931	ENST00000395667;ENST00000308799;ENST00000301938;ENST00000395665	.	.	.	3.59	3.59	0.41128	.	.	.	.	.	.	.	.	.	.	.	0.80722	D	1	.	.	.	.	.	.	.	.	.	.	.	.	.	.	10.2006	0.43082	0.0:0.0:0.0:1.0	.	.	.	.	.	-1	.	.	.	+	.	.	FBXW10	18608903	1.000000	0.71417	1.000000	0.80357	0.331000	0.28603	6.453000	0.73488	1.491000	0.48482	0.163000	0.16589	.		TCGA-F2-6879-01A-11D-2154-08	FBXW10-003	KNOWN	NAGNAG_splice_site|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000313531.2	1	0	0	104	111	0	20		0	0	0	0	20	2		0	0	0	0	0	2	1	1.000000	93	95	0	60	2								-20.000000	1	1	0	0		1	0	1	1	1.496731	1	0.670000	1.870000	0.515952	0.960000	8.300000e-01	1.000000	1.000000	0.955196	0.960000	1	9.000000e-01	1
SLC4A1	6521	broad.mit.edu	37	17	42332022	42332022	+	Silent	SNP	C	C	T	rs148412733	byFrequency	TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr17:42332022C>T	ENST00000262418.6	-	16	2054	c.1899G>A	c.(1897-1899)tcG>tcA	p.S633S		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1 (Diego blood group)			40		Breast(137;0.014)|Prostate(33;0.0181)			CATCAGGCACCGAGAGTTTCT	0.612000																								0							SO:0001819	synonymous_variant			ENST00000262418.6	1	0	hg19	CCDS11481.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	SLC4A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000346194.1	1	0	1	51	49	0	15		0	0	0	0	15	2		0	0	0	0	0	2	1	1.000000	50	49	0	15	2								-14.920640	1	0	121412	11	39	1	0	1	1	1.506177	1	0.670000	1.870000	0.506247	0.940000	7.800000e-01	1.000000	1.000000	0.932967	0.940000	1	8.600000e-01	9.900000e-01
PLCD3	113026	broad.mit.edu	37	17	43192471	43192471	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr17:43192471G>A	ENST00000322765.5	-	11	1812	c.1699C>T	c.(1699-1701)Cgg>Tgg	p.R567W	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3			17					CCTGCCTCCCGAATGAGTTTC	0.657000																								0							SO:0001583	missense			ENST00000322765.5	0	1	hg19		.	.	.	.	.	.	.	.	.	.	G	10.89	1.479804	0.26511	.	.	ENSG00000161714	ENST00000322765	T	0.68765	-0.35	3.78	-0.997	0.10215	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (2);Phospholipase C, phosphatidylinositol-specific, Y domain (3);	0.152498	0.44483	D	0.000455	T	0.49932	0.1586	.	.	.	0.33151	D	0.545763	B	0.22346	0.068	B	0.12837	0.008	T	0.49818	-0.8899	9	0.87932	D	0	.	6.6438	0.22925	0.1084:0.0:0.2189:0.6726	.	568	Q8N3E9	PLCD3_HUMAN	W	567	ENSP00000313731:R567W	ENSP00000313731:R567W	R	-	1	2	PLCD3	40547997	1.000000	0.71417	0.964000	0.40570	0.197000	0.23852	1.024000	0.30077	0.048000	0.15891	0.462000	0.41574	CGG		TCGA-F2-6879-01A-11D-2154-08	PLCD3-201	KNOWN	basic|appris_principal	protein_coding	protein_coding		0	0	0	3	31	0	11	0	9.757154e-01	0	86	0	11	2		0	0	0	0	0	2	1	0.803100	3	30	0	11	2								-7.627057	1	1	0	0		1	0	1	1	1.506177	1	0.670000	1.870000	0.506247	0.190000	5.000000e-02	0.430000	0.170000	0.215497	0.190000	0	1.100000e-01	3.100000e-01
MYBBP1A	10514	broad.mit.edu	37	17	4458561	4458561	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr17:4458561G>A	ENST00000254718.4	-	1	365	c.59C>T	c.(58-60)gCc>gTc	p.A20V	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.A20V			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a			24					GGCAGGCCGGGCGCCACTCTG	0.637000																								0							SO:0001583	missense			ENST00000254718.4	0	1	hg19	CCDS11046.1	.	.	.	.	.	.	.	.	.	.	G	11.27	1.590249	0.28357	.	.	ENSG00000132382	ENST00000381556;ENST00000254718;ENST00000426435	T;T	0.18657	2.2;2.21	3.65	-2.44	0.06502	.	0.961415	0.08483	N	0.939134	T	0.08537	0.0212	N	0.12182	0.205	0.09310	N	1	B;B	0.11235	0.002;0.004	B;B	0.11329	0.003;0.006	T	0.35450	-0.9788	10	0.23302	T	0.38	.	1.0496	0.01577	0.3956:0.1515:0.2986:0.1543	.	20;20	Q9BQG0;Q9BQG0-2	MBB1A_HUMAN;.	V	20	ENSP00000370968:A20V;ENSP00000254718:A20V	ENSP00000254718:A20V	A	-	2	0	MYBBP1A	4405310	0.095000	0.21747	0.011000	0.14972	0.013000	0.08279	-0.258000	0.08733	-0.739000	0.04809	-0.952000	0.02654	GCC		TCGA-F2-6879-01A-11D-2154-08	MYBBP1A-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000207488.2	1	0	1	34	24	0	9	1	9.999998e-01	20	8	0	9	2		0	0	0	0	0	2	1	1.000000	34	24	0	9	2								-20.000000	1	1	0	0		1	0	1	1	1.478377	1	0.670000	1.870000	0.503759	0.940000	7.900000e-01	1.000000	0.990000	0.940095	0.940000	1	8.800000e-01	9.900000e-01
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	T	C	rs121912666		TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	targeted			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr17:7578190T>C	ENST00000269305.4	-	6	848	c.659A>G	c.(658-660)tAt>tGt	p.Y220C	TP53_ENST00000445888.2_Missense_Mutation_p.Y220C|TP53_ENST00000574684.1_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.Y220C|TP53_ENST00000420246.2_Missense_Mutation_p.Y220C|TP53_ENST00000359597.4_Missense_Mutation_p.Y220C|TP53_ENST00000413465.2_Missense_Mutation_p.Y220C	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	p.Y220C(278)|p.Y127C(24)|p.Y220S(12)|p.?(11)|p.0?(8)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.Y127S(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*2(1)|p.V218fs*26(1)		24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		Acetylsalicylic acid(DB00945)	AGGCGGCTCATAGGGCACCAC	0.557000		111	Mis, N, F		breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			Pancreas(47;798 1329 9957 10801)	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		L, E, M, O	343	Substitution - Missense(315)|Unknown(11)|Whole gene deletion(8)|Deletion - In frame(5)|Deletion - Frameshift(3)|Insertion - Frameshift(1)	GRCh37	CM015378|CM951227	TP53	M	rs121912666	SO:0001583	missense	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	ENST00000269305.4	1	1	hg19	CCDS11118.1	.	.	.	.	.	.	.	.	.	.	T	22.1	4.248510	0.80024	.	.	ENSG00000141510	ENST00000413465;ENST00000359597;ENST00000269305;ENST00000455263;ENST00000420246;ENST00000445888;ENST00000396473;ENST00000545858;ENST00000509690;ENST00000514944	D;D;D;D;D;D;D;D	0.99840	-7.08;-7.08;-7.08;-7.08;-7.08;-7.08;-7.08;-7.08	5.28	5.28	0.74379	p53, DNA-binding domain (1);p53-like transcription factor, DNA-binding (1);p53/RUNT-type transcription factor, DNA-binding domain (1);	0.000000	0.85682	D	0.000000	D	0.99822	0.9921	M	0.89287	3.02	0.80722	D	1	D;D;D;D;D;D;D	0.89917	1.0;1.0;1.0;1.0;1.0;1.0;1.0	D;D;D;D;D;D;D	0.97110	1.0;0.998;0.996;1.0;0.999;0.998;1.0	D	0.96735	0.9542	10	0.87932	D	0	-1.87	13.4753	0.61306	0.0:0.0:0.0:1.0	.	181;220;220;127;220;220;220	B4E095;P04637-2;P04637-3;E9PFT5;P04637;Q1MSW8;E7EQX7	.;.;.;.;P53_HUMAN;.;.	C	220;220;220;220;220;220;209;127;88;127	ENSP00000410739:Y220C;ENSP00000352610:Y220C;ENSP00000269305:Y220C;ENSP00000398846:Y220C;ENSP00000391127:Y220C;ENSP00000391478:Y220C;ENSP00000425104:Y88C;ENSP00000423862:Y127C	ENSP00000269305:Y220C	Y	-	2	0	TP53	7518915	1.000000	0.71417	0.585000	0.28666	0.993000	0.82548	6.232000	0.72313	2.128000	0.65567	0.460000	0.39030	TAT		TCGA-F2-6879-01A-11D-2154-08	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367397.1	1	0	1	59	70	0	26	1	1	63	26	0	26	2	1	1	325	356	0	820	2	1	1.000000	56	68	0	26	2								-20.000000	1	1	121412	3	37	1	0	1	1	1.507814	1	0.670000	1.870000	0.506247	0.880000	7.300000e-01	1.000000	0.910000	0.888164	0.880000	1	8.000000e-01	9.600000e-01
CDH7	1005	broad.mit.edu	37	18	63526217	63526217	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr18:63526217G>A	ENST00000397968.2	+	9	1855	c.1429G>A	c.(1429-1431)Gat>Aat	p.D477N	CDH7_ENST00000323011.3_Missense_Mutation_p.D477N|CDH7_ENST00000536984.2_Missense_Mutation_p.D477N	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2			80		Esophageal squamous(42;0.129)			TGACATCAATGATAACGCCCC	0.428000																								0							SO:0001583	missense			ENST00000397968.2	0	1	hg19	CCDS11993.1	.	.	.	.	.	.	.	.	.	.	G	34	5.403313	0.96051	.	.	ENSG00000081138	ENST00000323011;ENST00000536984;ENST00000397966;ENST00000397968	T;T;T	0.75367	-0.93;-0.93;-0.93	5.32	5.32	0.75619	Cadherin (4);Cadherin conserved site (1);Cadherin-like (1);	0.000000	0.85682	D	0.000000	D	0.91693	0.7374	H	0.97707	4.06	0.80722	D	1	D;D	0.89917	0.996;1.0	D;D	0.83275	0.945;0.996	D	0.94311	0.7545	10	0.87932	D	0	.	19.347	0.94367	0.0:0.0:1.0:0.0	.	477;477	F5H5X9;Q9ULB5	.;CADH7_HUMAN	N	477	ENSP00000319166:D477N;ENSP00000443030:D477N;ENSP00000381058:D477N	ENSP00000319166:D477N	D	+	1	0	CDH7	61677197	1.000000	0.71417	1.000000	0.80357	0.924000	0.55760	9.666000	0.98612	2.648000	0.89879	0.467000	0.42956	GAT		TCGA-F2-6879-01A-11D-2154-08	CDH7-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000256217.2	0	0	0	6	192	0	34		0	0	0	0	34	2		0	0	0	0	0	2	1	0.963425	6	188	0	33	2								-3.486004	1	1	0	0		1	0	1	1	1.455464	1	0.670000	1.870000	0.503759	0.060000	2.000000e-02	0.120000	0.060000	0.069125	0.060000	0	3.000000e-02	9.000000e-02
LAMA1	284217	broad.mit.edu	37	18	6943188	6943188	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr18:6943188C>T	ENST00000389658.3	-	62	9151	c.9058G>A	c.(9058-9060)Ggc>Agc	p.G3020S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1			205		Colorectal(10;0.172)			CCAGGATAGCCACCAACATAA	0.502000																								0							SO:0001583	missense			ENST00000389658.3	1	1	hg19	CCDS32787.1	.	.	.	.	.	.	.	.	.	.	C	35	5.551971	0.96501	.	.	ENSG00000101680	ENST00000389658	T	0.70869	-0.52	5.86	5.86	0.93980	Concanavalin A-like lectin/glucanase (1);Concanavalin A-like lectin/glucanase, subgroup (1);Laminin G domain (2);Laminin G, subdomain 1 (1);	0.000000	0.85682	D	0.000000	D	0.88336	0.6409	M	0.90870	3.155	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.97110	1.0;1.0	D	0.89477	0.3747	10	0.62326	D	0.03	.	20.1772	0.98182	0.0:1.0:0.0:0.0	.	3020;350	P25391;B3KSD8	LAMA1_HUMAN;.	S	3020	ENSP00000374309:G3020S	ENSP00000374309:G3020S	G	-	1	0	LAMA1	6933188	1.000000	0.71417	0.972000	0.41901	0.992000	0.81027	7.399000	0.79935	2.778000	0.95560	0.655000	0.94253	GGC		TCGA-F2-6879-01A-11D-2154-08	LAMA1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000257369.1	1	0	1	80	170	0	36	0	0	0	1	0	36	2		0	0	0	0	0	2	1	1.000000	80	168	0	36	2								-20.000000	1	1	0	0		1	1	2	3	2.151162	0	0.670000	1.870000	0.675436	0.970000	7.900000e-01	1.000000	1.000000	0.951432	0.970000	1	8.800000e-01	1
GRIN2D	2906	broad.mit.edu	37	19	48918276	48918276	+	Missense_Mutation	SNP	G	G	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr19:48918276G>C	ENST00000263269.3	+	6	1656	c.1568G>C	c.(1567-1569)gGc>gCc	p.G523A		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D			37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		Acamprosate(DB00659)|Acetylcysteine(DB06151)|Atomoxetine(DB00289)|Gabapentin(DB00996)|Ketobemidone(DB06738)|Milnacipran(DB04896)|Orphenadrine(DB01173)|Pentobarbital(DB00312)|Pethidine(DB00454)|Phenobarbital(DB01174)|Secobarbital(DB00418)	GTCTGGAACGGCATGATCGGG	0.637000																								0							SO:0001583	missense			ENST00000263269.3	1	1	hg19	CCDS12719.1	.	.	.	.	.	.	.	.	.	.	G	28.8	4.950995	0.92660	.	.	ENSG00000105464	ENST00000263269	T	0.56444	0.46	4.88	4.88	0.63580	Extracellular solute-binding protein, family 3 (1);Glutamate receptor, L-glutamate/glycine-binding (1);Ionotropic glutamate receptor (1);	0.000000	0.85682	D	0.000000	T	0.79341	0.4429	M	0.92268	3.29	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	D	0.85032	0.0918	10	0.87932	D	0	.	17.1833	0.86860	0.0:0.0:1.0:0.0	.	523	O15399	NMDE4_HUMAN	A	523	ENSP00000263269:G523A	ENSP00000263269:G523A	G	+	2	0	GRIN2D	53610088	1.000000	0.71417	1.000000	0.80357	0.959000	0.62525	9.546000	0.98097	2.445000	0.82738	0.655000	0.94253	GGC		TCGA-F2-6879-01A-11D-2154-08	GRIN2D-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000466121.1	1	0	1	98	238	0	24	1	1	49	53	0	24	2		0	0	0	0	0	2	1	1.000000	96	232	0	24	2								-7.904220	1	1	0	0		1	2	2	4	2.234464	0	0.670000	1.870000	0.690722	0.930000	7.700000e-01	1.000000	1.000000	0.929127	0.930000	1	8.500000e-01	1
ZIM2	23619	broad.mit.edu	37	19	57286068	57286068	+	Silent	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr19:57286068G>A	ENST00000391708.3	-	12	2114	c.1572C>T	c.(1570-1572)tgC>tgT	p.C524C	AC006115.3_ENST00000595954.1_RNA|ZIM2_ENST00000599935.1_Silent_p.C524C|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000593711.1_Silent_p.C524C|ZIM2_ENST00000601070.1_Silent_p.C524C|ZIM2_ENST00000221722.5_Silent_p.C524C	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	p.C524C(1)		44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)			AACAGTGATCGCACTCAACAG	0.458000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000391708.3	0	1	hg19	CCDS33123.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	ZIM2-202	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000416094.2	1	0	0	64	189	0	38		0	0	0	0	38	2		0	0	0	0	0	2	1	1.000000	62	187	0	37	2								-20.000000	1	1	121412	3	32	1	2	2	4	2.221572	0	0.670000	1.870000	0.688767	0.800000	6.300000e-01	1.000000	0.800000	0.819033	0.800000	0	7.100000e-01	9.200000e-01
TMEM82	388595	broad.mit.edu	37	1	16069389	16069389	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:16069389G>A	ENST00000375782.1	+	2	286	c.148G>A	c.(148-150)Gtg>Atg	p.V50M	RP11-169K16.4_ENST00000418525.1_RNA|TMEM82_ENST00000465575.1_Intron	NM_001013641.1	NP_001013663.1	A0PJX8	TMM82_HUMAN	transmembrane protein 82			13		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)			TTACTTCTTCGTGGGCTGTGC	0.662000																								0							SO:0001583	missense			ENST00000375782.1	0	1	hg19	CCDS30608.1	.	.	.	.	.	.	.	.	.	.	G	18.65	3.670358	0.67814	.	.	ENSG00000162460	ENST00000375782	T	0.50277	0.75	4.48	2.05	0.26809	.	0.816927	0.10716	N	0.642304	T	0.53674	0.1811	M	0.62723	1.935	0.22240	N	0.99926	D	0.63046	0.992	P	0.54706	0.759	T	0.41770	-0.9490	10	0.72032	D	0.01	-12.4796	5.2429	0.15481	0.1953:0.1904:0.6142:0.0	.	50	A0PJX8	TMM82_HUMAN	M	50	ENSP00000364938:V50M	ENSP00000364938:V50M	V	+	1	0	TMEM82	15941976	0.000000	0.05858	0.996000	0.52242	0.935000	0.57460	0.266000	0.18534	0.953000	0.37825	0.556000	0.70494	GTG		TCGA-F2-6879-01A-11D-2154-08	TMEM82-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000008471.2	1	0	0	13	209	0	15	0	0	0	1	0	15	2		0	0	0	0	0	2	1	0.999482	13	203	0	15	2								-16.277890	1	1	121312	1	28	1	2	2	4	2.218626	0	0.670000	1.870000	0.688767	0.190000	1.000000e-01	1.000000	0.180000	0.255778	0.190000	0	1.400000e-01	2.700000e-01
DUSP27	92235	broad.mit.edu	37	1	167095421	167095421	+	Silent	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:167095421C>T	ENST00000361200.2	+	6	1219	c.1053C>T	c.(1051-1053)taC>taT	p.Y351Y	DUSP27_ENST00000485151.1_3'UTR|DUSP27_ENST00000443333.1_Silent_p.Y351Y|DUSP27_ENST00000271385.5_Silent_p.Y351Y			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	p.Y351Y(1)		89					AGAAACTGTACGAGCAGTGGA	0.662000																								1	Substitution - coding silent(1)						SO:0001819	synonymous_variant			ENST00000361200.2	1	1	hg19	CCDS30932.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	DUSP27-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000083244.1	1	0	1	12	37	0	9		0	0	0	0	9	2		0	0	0	0	0	2	1	0.999370	10	37	0	9	2								-19.999960	1	1	0	0		1	1	2	3	2.149153	0	0.670000	1.870000	0.674364	0.750000	4.300000e-01	1.000000	1.000000	0.760642	0.750000	0	5.800000e-01	9.700000e-01
B3GALT2	8707	broad.mit.edu	37	1	193150555	193150555	+	Missense_Mutation	SNP	A	A	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:193150555A>C	ENST00000367434.4	-	2	893	c.138T>G	c.(136-138)caT>caG	p.H46Q	CDC73_ENST00000367435.3_Intron	NM_003783.3	NP_003774.1	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2			16					GCAGCCAGTCATGATGATTGA	0.428000																								0							SO:0001583	missense			ENST00000367434.4	1	1	hg19	CCDS1383.1	.	.	.	.	.	.	.	.	.	.	A	0.052	-1.246213	0.01481	.	.	ENSG00000162630	ENST00000367434	T	0.34859	1.34	5.25	-1.75	0.08031	.	0.253868	0.42294	N	0.000722	T	0.12305	0.0299	N	0.03608	-0.345	0.39789	D	0.972407	B	0.06786	0.001	B	0.04013	0.001	T	0.09662	-1.0664	10	0.24483	T	0.36	.	6.4842	0.22079	0.4727:0.0:0.4067:0.1206	.	46	O43825	B3GT2_HUMAN	Q	46	ENSP00000356404:H46Q	ENSP00000356404:H46Q	H	-	3	2	B3GALT2	191417178	0.028000	0.19301	0.996000	0.52242	0.117000	0.20001	-0.633000	0.05483	-0.242000	0.09667	0.533000	0.62120	CAT		TCGA-F2-6879-01A-11D-2154-08	B3GALT2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000086759.1	1	0	0	27	391	0	32	0	1.312380e-02	0	3	0	32	2		0	0	0	0	0	2	1	1.000000	25	386	0	32	2								-20.000000	1	1	0	0		1	1	2	3	2.145058	0	0.670000	1.870000	0.674364	0.190000	1.200000e-01	1.000000	0.200000	0.224424	0.190000	0	1.500000e-01	2.400000e-01
HLX	3142	broad.mit.edu	37	1	221057767	221057767	+	Silent	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:221057767G>A	ENST00000366903.6	+	4	2689	c.1188G>A	c.(1186-1188)ggG>ggA	p.G396G	HLX_ENST00000549319.1_Silent_p.G182G	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox			32					GGACTGAGGGGAGTGAGCGTT	0.652000																								0							SO:0001819	synonymous_variant			ENST00000366903.6	1	1	hg19	CCDS1527.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	HLX-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000090902.3	0	0	1	67	150	0	28	1	1	3	75	0	28	2		0	0	0	0	0	2	1	1.000000	65	143	0	27	2								-20.000000	1	1	0	0		1	1	2	3	2.145058	0	0.670000	1.870000	0.674364	0.930000	7.500000e-01	1.000000	1.000000	0.924746	0.930000	1	8.300000e-01	1
OBSCN	84033	broad.mit.edu	37	1	228479741	228479741	+	Silent	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:228479741C>T	ENST00000422127.1	+	39	10526	c.10482C>T	c.(10480-10482)taC>taT	p.Y3494Y	OBSCN_ENST00000284548.11_Silent_p.Y3494Y|OBSCN_ENST00000366707.4_Silent_p.Y613Y|OBSCN_ENST00000570156.2_Silent_p.Y3923Y|OBSCN_ENST00000359599.6_Silent_p.Y2341Y|OBSCN_ENST00000366709.4_Silent_p.Y613Y	NM_001098623.2	NP_001092093.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF			223		Prostate(94;0.0405)			GGGACAGATACATCCTGAGGC	0.632000																								0							SO:0001819	synonymous_variant			ENST00000422127.1	1	1	hg19	CCDS58065.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	OBSCN-204	KNOWN	basic|CCDS	protein_coding	protein_coding		1	0	0	34	426	0	59		0	0	0	0	59	2		0	0	0	0	0	2	1	1.000000	32	411	0	58	2								-9.323665	1	1	121040	1	32	1	1	2	3	2.145058	0	0.670000	1.870000	0.674364	0.220000	1.500000e-01	1.000000	0.220000	0.251126	0.220000	0	1.800000e-01	2.700000e-01
RSPO1	284654	broad.mit.edu	37	1	38079563	38079563	+	Splice_Site	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr1:38079563C>T	ENST00000401069.1	-	6	1150	c.438G>A	c.(436-438)gcG>gcA	p.A146A	RSPO1_ENST00000356545.2_Splice_Site_p.A146A|RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000401070.1_Intron|RSPO1_ENST00000373059.1_Splice_Site_p.A119A|RSPO1_ENST00000401068.1_Splice_Site_p.A146A	NM_001242908.1	NP_001229837.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1			12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			TTTCACATTGCGCTGGCAGGA	0.617000													GBM(122;680 2230 27822 42821)											0							SO:0001630	splice_region_variant			ENST00000401069.1	1	0	hg19	CCDS41304.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	RSPO1-003	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000012477.2	1	0	1	116	217	0	45	0	6.774471e-01	0	6	0	45	2		0	0	0	0	0	2	1	1.000000	115	212	0	43	2								-12.961280	1	1	120878	5	40	1	2	2	4	2.227741	0	0.670000	1.870000	0.690722	0.990000	9.400000e-01	1.000000	1.000000	0.996961	0.990000	1	9.900000e-01	1
MYT1	4661	broad.mit.edu	37	20	62838994	62838994	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr20:62838994G>A	ENST00000328439.1	+	7	809	c.445G>A	c.(445-447)Gcc>Acc	p.A149T	MYT1_ENST00000536311.1_Missense_Mutation_p.A149T|MYT1_ENST00000360149.4_Intron	NM_004535.2	NP_004526.1	Q99640	PMYT1_HUMAN	myelin transcription factor 1			55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)				CATCGGCAGCGCCACTGCCTC	0.552000													GBM(59;481 1041 20555 21139 33705)											0							SO:0001583	missense			ENST00000328439.1	1	1	hg19	CCDS13558.1	.	.	.	.	.	.	.	.	.	.	g	6.847	0.525511	0.13066	.	.	ENSG00000196132	ENST00000328439;ENST00000536311	T;T	0.45276	0.9;0.91	4.32	-0.391	0.12446	.	0.867931	0.10082	N	0.718370	T	0.14227	0.0344	N	0.03608	-0.345	0.20196	N	0.99992	B	0.02656	0.0	B	0.01281	0.0	T	0.24584	-1.0156	10	0.13470	T	0.59	-1.3728	1.1079	0.01698	0.2243:0.3488:0.2532:0.1737	.	149	Q01538	MYT1_HUMAN	T	149	ENSP00000327465:A149T;ENSP00000442412:A149T	ENSP00000327465:A149T	A	+	1	0	MYT1	62309438	0.001000	0.12720	0.061000	0.19648	0.619000	0.37552	-0.116000	0.10724	-0.138000	0.11434	-0.267000	0.10333	GCC		TCGA-F2-6879-01A-11D-2154-08	MYT1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000080297.1	1	0	1	202	623	0	73		0	0	0	0	73	2		0	0	0	0	0	2	1	1.000000	194	614	0	73	2								-6.339868	1	1	121412	42	47	1	1	2	3	2.773911	1	0.670000	1.870000	0.752809	0.970000	8.500000e-01	1.000000	1.000000	0.962965	0.970000	1	9.100000e-01	1
TRPM2	7226	broad.mit.edu	37	21	45838383	45838383	+	Nonsense_Mutation	SNP	C	C	T	rs143493112	byFrequency	TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr21:45838383C>T	ENST00000397928.1	+	22	3851	c.3406C>T	c.(3406-3408)Cga>Tga	p.R1136*	TRPM2_ENST00000397932.2_Nonsense_Mutation_p.R1136*|AP001065.2_ENST00000456880.1_RNA|AP001065.2_ENST00000423310.1_RNA|TRPM2_ENST00000300482.5_Nonsense_Mutation_p.R1136*|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Nonsense_Mutation_p.R1116*	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2			76					CCTCCAGAACCGACAGTTCCA	0.607000																								0							SO:0001587	stop_gained			ENST00000397928.1	0	1	hg19	CCDS13710.1	1	4.578754578754579E-4	0	0.0	0	0.0	0	0.0	1	0.0013192612137203166	C	38	7.041531	0.98021	6.81E-4	0.001395	ENSG00000142185	ENST00000300482;ENST00000397928;ENST00000300481;ENST00000397932	.	.	.	4.81	4.81	0.61882	.	0.605119	0.16448	N	0.213991	.	.	.	.	.	.	0.80722	A	1	.	.	.	.	.	.	.	.	.	.	0.15066	T	0.55	-12.6798	11.4159	0.49951	0.0:0.9154:0.0:0.0846	.	.	.	.	X	1136;1136;1116;1136	.	ENSP00000300481:R1116X	R	+	1	2	TRPM2	44662811	0.834000	0.29399	0.303000	0.25071	0.096000	0.18686	3.140000	0.50585	2.395000	0.81488	0.514000	0.50259	CGA		TCGA-F2-6879-01A-11D-2154-08	TRPM2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000098086.1	1	0	0	267	642	0	106	0	6.572214e-01	0	7	0	106	2		0	0	0	0	0	2	1	1.000000	265	632	0	103	2								-2.665581	1	1	121410	100	54	1	1	2	3	2.119469	0	0.670000	1.870000	0.672196	0.870000	7.800000e-01	0.980000	0.880000	0.884608	0.870000	1	8.300000e-01	9.300000e-01
COL18A1	80781	broad.mit.edu	37	21	46925862	46925862	+	Missense_Mutation	SNP	C	C	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr21:46925862C>A	ENST00000359759.4	+	36	4464	c.4443C>A	c.(4441-4443)aaC>aaA	p.N1481K	SLC19A1_ENST00000567670.1_Intron|COL18A1_ENST00000355480.5_Missense_Mutation_p.N1246K|COL18A1_ENST00000400337.2_Missense_Mutation_p.N1066K			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1			25					GCGTGCAGAACGGGTTCCGGA	0.667000																								0							SO:0001583	missense			ENST00000359759.4	1	1	hg19		.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	C|C	11.69|11.69	1.714181|1.714181	0.30413|0.30413	.|.	.|.	ENSG00000182871|ENSG00000182871	ENST00000400337;ENST00000400347;ENST00000355480;ENST00000359759;ENST00000539645;ENST00000342220|ENST00000423214	T;T;T;T|.	0.39787|.	1.06;1.06;1.06;1.06|.	3.69|3.69	-5.5|-5.5	0.02576|0.02576	Collagenase NC10/endostatin (1);|.	0.392987|.	0.24798|.	U|.	0.035513|.	T|T	0.41604|0.41604	0.1166|0.1166	L|L	0.41236|0.41236	1.265|1.265	0.34304|0.34304	D|D	0.684693|0.684693	D;P;P;P|.	0.53312|.	0.959;0.8;0.949;0.901|.	P;B;P;B|.	0.55055|.	0.767;0.392;0.655;0.338|.	T|T	0.49000|0.49000	-0.8984|-0.8984	10|5	0.10377|.	T|.	0.69|.	.|.	7.3656|7.3656	0.26770|0.26770	0.0:0.1979:0.1207:0.6814|0.0:0.1979:0.1207:0.6814	.|.	1481;1063;1246;1066|.	P39060;D3DSM4;P39060-1;P39060-2|.	COIA1_HUMAN;.;.;.|.	K|K	1066;1066;1246;1481;1481;414|62	ENSP00000383191:N1066K;ENSP00000347665:N1246K;ENSP00000352798:N1481K;ENSP00000339118:N414K|.	ENSP00000339118:N414K|.	N|T	+|+	3|2	2|0	COL18A1|COL18A1	45750290|45750290	0.000000|0.000000	0.05858|0.05858	0.001000|0.001000	0.08648|0.08648	0.156000|0.156000	0.22039|0.22039	-1.776000|-1.776000	0.01781|0.01781	-1.191000|-1.191000	0.02695|0.02695	-0.658000|-0.658000	0.03865|0.03865	AAC|ACG		TCGA-F2-6879-01A-11D-2154-08	COL18A1-201	KNOWN	basic|appris_principal	protein_coding	protein_coding	OTTHUMT00000206827.1	1	0	1	117	336	0	62	1	1	4	190	0	62	2		0	0	0	0	1	2	1	1.000000	117	331	0	59	2								-3.143212	1	1	0	0		1	1	2	3	2.119469	0	0.670000	1.870000	0.672196	0.770000	6.500000e-01	0.920000	0.770000	0.780665	0.770000	0	7.100000e-01	8.400000e-01
OSBPL6	114880	broad.mit.edu	37	2	179193055	179193055	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr2:179193055G>A	ENST00000190611.4	+	5	644	c.268G>A	c.(268-270)Gag>Aag	p.E90K	OSBPL6_ENST00000477097.1_3'UTR|OSBPL6_ENST00000315022.2_Missense_Mutation_p.E69K|OSBPL6_ENST00000409631.1_Missense_Mutation_p.E90K|OSBPL6_ENST00000392505.2_Missense_Mutation_p.E90K|OSBPL6_ENST00000409045.3_Missense_Mutation_p.E90K|OSBPL6_ENST00000359685.3_Missense_Mutation_p.E90K|OSBPL6_ENST00000357080.4_Missense_Mutation_p.E90K	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6			46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)		AGACAAACATGAGGGCTTTAT	0.378000																								0							SO:0001583	missense			ENST00000190611.4	1	1	hg19	CCDS2277.1	.	.	.	.	.	.	.	.	.	.	G	28.7	4.939758	0.92526	.	.	ENSG00000079156	ENST00000392505;ENST00000359685;ENST00000357080;ENST00000409045;ENST00000190611;ENST00000409631;ENST00000315022	T;T;T;T;T;T;T	0.14893	2.55;2.51;2.47;2.53;2.54;2.51;2.56	5.49	5.49	0.81192	Pleckstrin homology-type (1);Pleckstrin homology domain (2);	0.000000	0.85682	D	0.000000	T	0.38427	0.1040	L	0.60957	1.885	0.80722	D	1	B;D;D;D;D;D	0.76494	0.421;0.999;0.996;0.999;0.997;0.998	B;D;D;D;D;D	0.83275	0.399;0.993;0.981;0.996;0.98;0.991	T	0.03695	-1.1012	10	0.15952	T	0.53	-18.931	19.3787	0.94523	0.0:0.0:1.0:0.0	.	90;69;90;90;90;90	Q9BZF3-4;Q9BZF3-3;Q9BZF3-2;Q9BZF3-5;Q9BZF3;Q86V84	.;.;.;.;OSBL6_HUMAN;.	K	90;90;90;90;90;90;69	ENSP00000376293:E90K;ENSP00000352713:E90K;ENSP00000349591:E90K;ENSP00000387248:E90K;ENSP00000190611:E90K;ENSP00000386885:E90K;ENSP00000318723:E69K	ENSP00000190611:E90K	E	+	1	0	OSBPL6	178901301	1.000000	0.71417	1.000000	0.80357	0.983000	0.72400	9.869000	0.99810	2.577000	0.86979	0.655000	0.94253	GAG		TCGA-F2-6879-01A-11D-2154-08	OSBPL6-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000334393.2	1	0	0	28	402	0	23	0	0	0	1	0	23	2		0	0	0	0	0	2	1	1.000000	28	396	0	23	2								-3.318774	1	1	0	0		1	0	0	0	2.057908	0	0.670000	1.870000	0.665518	0.190000	1.200000e-01	0.270000	0.190000	0.197472	0.190000	0	1.500000e-01	2.300000e-01
ZDBF2	57683	broad.mit.edu	37	2	207174767	207174767	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr2:207174767G>A	ENST00000374423.3	+	5	5901	c.5515G>A	c.(5515-5517)Gat>Aat	p.D1839N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2			95					AATGAGAGAAGATGACATAAA	0.413000																								0							SO:0001583	missense			ENST00000374423.3	1	1	hg19	CCDS46501.1	.	.	.	.	.	.	.	.	.	.	G	22.0	4.233468	0.79688	.	.	ENSG00000204186	ENST00000374423	T	0.71934	-0.61	5.48	4.56	0.56223	.	.	.	.	.	T	0.63663	0.2530	L	0.53249	1.67	0.32979	D	0.523413	P	0.46859	0.885	B	0.37601	0.254	T	0.73329	-0.4017	9	0.46703	T	0.11	.	12.884	0.58032	0.0832:0.0:0.9168:0.0	.	1839	Q9HCK1	ZDBF2_HUMAN	N	1839	ENSP00000363545:D1839N	ENSP00000363545:D1839N	D	+	1	0	ZDBF2	206883012	1.000000	0.71417	0.998000	0.56505	0.954000	0.61252	3.969000	0.56816	1.244000	0.43870	0.551000	0.68910	GAT		TCGA-F2-6879-01A-11D-2154-08	ZDBF2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000336458.1	1	0	1	80	154	0	19	0	0	0	1	0	19	2		0	0	0	0	0	2	1	1.000000	80	152	0	19	2								-20.000000	1	1	0	0		1	0	0	0	2.057908	0	0.670000	1.870000	0.665518	0.990000	8.200000e-01	1.000000	1.000000	0.967908	0.990000	1	9.100000e-01	1
IGSF10	285313	broad.mit.edu	37	3	151160955	151160955	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr3:151160955C>T	ENST00000282466.3	-	5	5779	c.5780G>A	c.(5779-5781)cGa>cAa	p.R1927Q	IGSF10_ENST00000495443.1_5'Flank	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10			116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		TACTACTCTTCGCTCCGAACC	0.433000																								0							SO:0001583	missense			ENST00000282466.3	1	1	hg19	CCDS3160.1	.	.	.	.	.	.	.	.	.	.	C	17.32	3.360817	0.61403	0.0	1.16E-4	ENSG00000152580	ENST00000282466;ENST00000544042	T	0.66099	-0.19	5.01	4.1	0.47936	Immunoglobulin I-set (1);Immunoglobulin-like (1);Immunoglobulin-like fold (1);	0.000000	0.51477	D	0.000082	T	0.72503	0.3468	L	0.48642	1.525	0.38886	D	0.957016	D	0.89917	1.0	D	0.91635	0.999	T	0.73251	-0.4042	9	.	.	.	.	14.9921	0.71396	0.0:0.8565:0.1435:0.0	.	1927	Q6WRI0	IGS10_HUMAN	Q	1927;554	ENSP00000282466:R1927Q	.	R	-	2	0	IGSF10	152643645	0.976000	0.34144	0.759000	0.31340	0.552000	0.35366	4.862000	0.62976	1.055000	0.40461	0.591000	0.81541	CGA		TCGA-F2-6879-01A-11D-2154-08	IGSF10-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000357782.1	1	0	1	233	473	0	64	0	1.092394e-01	1	1	0	64	2		0	0	0	0	0	2	1	1.000000	227	467	0	62	2								-20.000000	1	1	121412	13	44	1	1	2	3	2.107791	0	0.670000	1.870000	0.671102	0.980000	8.800000e-01	1.000000	1.000000	0.972819	0.980000	1	9.300000e-01	1
SAMD7	344658	broad.mit.edu	37	3	169644398	169644398	+	Silent	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr3:169644398C>T	ENST00000428432.2	+	6	737	c.348C>T	c.(346-348)ccC>ccT	p.P116P	SAMD7_ENST00000335556.3_Silent_p.P116P	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7			31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)		AAATTAATCCCAAGGGACTAG	0.478000																								0							SO:0001819	synonymous_variant			ENST00000428432.2	1	1	hg19	CCDS3209.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	SAMD7-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000351959.1	1	0	1	136	304	0	31		0	0	0	0	31	2		0	0	0	0	0	2	1	1.000000	134	298	0	30	2								-10.366950	1	1	0	0		1	1	2	3	2.107791	0	0.670000	1.870000	0.671102	0.920000	7.900000e-01	1.000000	1.000000	0.922554	0.920000	1	8.500000e-01	9.900000e-01
CPN2	1370	broad.mit.edu	37	3	194062372	194062372	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr3:194062372G>A	ENST00000323830.3	-	2	1149	c.1060C>T	c.(1060-1062)Cca>Tca	p.P354S	CPN2_ENST00000429275.1_Missense_Mutation_p.P354S	NM_001080513.2	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2			27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)		AAGAGGGCTGGGTGCAGCGCC	0.562000																								0							SO:0001583	missense			ENST00000323830.3	1	1	hg19	CCDS33920.1	.	.	.	.	.	.	.	.	.	.	G	0.420	-0.908595	0.02434	.	.	ENSG00000178772	ENST00000323830;ENST00000429275	T;T	0.23950	1.88;1.88	5.56	0.155	0.14906	.	0.211850	0.24065	N	0.041861	T	0.11239	0.0274	N	0.17474	0.49	0.09310	N	1	B	0.17667	0.023	B	0.20577	0.03	T	0.35919	-0.9769	10	0.08179	T	0.78	.	6.8929	0.24241	0.0642:0.3887:0.3736:0.1736	.	354	P22792	CPN2_HUMAN	S	354	ENSP00000319464:P354S;ENSP00000402232:P354S	ENSP00000319464:P354S	P	-	1	0	CPN2	195544067	0.034000	0.19679	0.024000	0.17045	0.784000	0.44337	-0.044000	0.12023	0.080000	0.16959	0.655000	0.94253	CCA		TCGA-F2-6879-01A-11D-2154-08	CPN2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000342856.2	1	0	1	108	211	0	45	0	0	0	1	0	45	2		0	0	0	0	0	2	1	1.000000	104	202	0	45	2								-11.615470	1	1	0	0		1	1	2	3	2.139295	0	0.670000	1.870000	0.674364	0.990000	8.600000e-01	1.000000	1.000000	0.979953	0.990000	1	9.400000e-01	1
ZNF662	389114	broad.mit.edu	37	3	42950359	42950359	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr3:42950359C>T	ENST00000541208.1	+	3	478	c.109C>T	c.(109-111)Cgg>Tgg	p.R37W	KRBOX1_ENST00000426937.1_5'UTR|ZNF662_ENST00000422021.1_Missense_Mutation_p.R37W|ZNF662_ENST00000328199.6_Missense_Mutation_p.R97W|ZNF662_ENST00000430067.2_3'UTR|ZNF662_ENST00000440367.2_Missense_Mutation_p.R37W			Q6ZS27	ZN662_HUMAN	zinc finger protein 662			15					CTCGGTTCCTCGGGGAGCTCT	0.542000																								0							SO:0001583	missense			ENST00000541208.1	1	1	hg19	CCDS2708.1	2	9.157509157509158E-4	1	0.0020325203252032522	0	0.0	1	0.0017482517482517483	0	0.0	C	1.020	-0.685146	0.03328	0.0	1.16E-4	ENSG00000182983	ENST00000440367;ENST00000328199;ENST00000541208;ENST00000422021	T;T;T	0.08546	3.08;3.12;3.08	3.08	0.535	0.17133	Krueppel-associated box (1);	.	.	.	.	T	0.12817	0.0311	M	0.82823	2.61	0.09310	N	1	B;B	0.10296	0.003;0.001	B;B	0.04013	0.001;0.0	T	0.20907	-1.0261	9	0.37606	T	0.19	.	9.101	0.36669	0.0:0.7309:0.0:0.2691	.	97;37	F8W7S8;Q6ZS27	.;ZN662_HUMAN	W	37;97;37;37	ENSP00000405047:R37W;ENSP00000329264:R97W;ENSP00000446208:R37W	ENSP00000329264:R97W	R	+	1	2	ZNF662	42925363	0.000000	0.05858	0.001000	0.08648	0.003000	0.03518	-0.072000	0.11486	-0.317000	0.08677	-1.134000	0.01955	CGG		TCGA-F2-6879-01A-11D-2154-08	ZNF662-201	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000256646.4	1	0	0	166	365	0	31	0	3.719609e-01	1	3	0	31	2		0	0	0	0	0	2	1	1.000000	166	360	0	30	2								-12.661240	1	1	121380	6	40	1	1	2	3	2.102732	0	0.670000	1.870000	0.671102	0.930000	8.100000e-01	1.000000	1.000000	0.932642	0.930000	1	8.700000e-01	1
ARSI	340075	broad.mit.edu	37	5	149677192	149677192	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr5:149677192C>T	ENST00000328668.7	-	2	1874	c.1295G>A	c.(1294-1296)gGc>gAc	p.G432D		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I			23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		ATCGCCATAGCCGGGGTCTCC	0.657000																								0							SO:0001583	missense			ENST00000328668.7	1	1	hg19	CCDS34275.1	.	.	.	.	.	.	.	.	.	.	C	17.81	3.481846	0.63849	.	.	ENSG00000183876	ENST00000328668;ENST00000515301	D;D	0.98313	-4.86;-4.86	4.45	4.45	0.53987	Sulfatase (1);Alkaline-phosphatase-like, core domain (1);	0.000000	0.85682	D	0.000000	D	0.98147	0.9388	L	0.43598	1.365	0.80722	D	1	D	0.89917	1.0	D	0.97110	1.0	D	0.97760	1.0220	10	0.27785	T	0.31	.	17.2703	0.87099	0.0:1.0:0.0:0.0	.	432	Q5FYB1	ARSI_HUMAN	D	432;289	ENSP00000333395:G432D;ENSP00000426879:G289D	ENSP00000333395:G432D	G	-	2	0	ARSI	149657385	1.000000	0.71417	0.899000	0.35326	0.734000	0.41952	7.320000	0.79064	2.296000	0.77279	0.561000	0.74099	GGC		TCGA-F2-6879-01A-11D-2154-08	ARSI-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000373681.1	1	0	1	138	235	0	41	0	9.664080e-01	0	12	0	41	2		0	0	0	0	0	2	1	1.000000	136	234	0	40	2								-20.000000	1	1	0	0		1	1	2	3	2.125628	0	0.670000	1.870000	0.672196	0.990000	9.600000e-01	1.000000	1.000000	0.997940	0.990000	1	9.900000e-01	1
FLT4	2324	broad.mit.edu	37	5	180039610	180039610	+	Splice_Site	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr5:180039610G>A	ENST00000261937.6	-	26	3511	c.3433C>T	c.(3433-3435)Cgc>Tgc	p.R1145C	FLT4_ENST00000502649.1_Splice_Site_p.R1145C|FLT4_ENST00000393347.3_Splice_Site_p.R1145C	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4			71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Axitinib(DB06626)|Pazopanib(DB06589)|Regorafenib(DB08896)|Sorafenib(DB00398)|Sunitinib(DB01268)	ATGATGCGGCGTCTGCAGGAT	0.667000													Colon(97;1075 1466 27033 27547 35871)											0							SO:0001630	splice_region_variant			ENST00000261937.6	1	0	hg19	CCDS4457.1	.	.	.	.	.	.	.	.	.	.	g	14.52	2.561024	0.45590	.	.	ENSG00000037280	ENST00000261937;ENST00000393347;ENST00000502649	D;D;D	0.82984	-1.67;-1.67;-1.67	3.57	3.57	0.40892	Serine-threonine/tyrosine-protein kinase (1);Protein kinase-like domain (1);Tyrosine-protein kinase, catalytic domain (1);Protein kinase, catalytic domain (1);	.	.	.	.	T	0.81683	0.4874	L	0.35487	1.065	0.52501	D	0.999952	D;D	0.61697	0.99;0.99	P;P	0.61658	0.892;0.892	T	0.81304	-0.0993	9	0.87932	D	0	.	4.5402	0.12054	0.3012:0.0:0.6988:0.0	.	1145;1145	E9PD35;P35916	.;VGFR3_HUMAN	C	1145	ENSP00000261937:R1145C;ENSP00000377016:R1145C;ENSP00000426057:R1145C	ENSP00000261937:R1145C	R	-	1	0	FLT4	179972216	1.000000	0.71417	0.961000	0.40146	0.110000	0.19582	5.246000	0.65411	2.011000	0.59026	0.457000	0.33378	CGC		TCGA-F2-6879-01A-11D-2154-08	FLT4-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000253527.4	1	0	0	18	308	0	26	0	1.728918e-01	0	13	0	26	2		0	0	0	0	0	2	1	0.999983	16	308	0	26	2								-19.702080	1	1	121412	7	39	1	1	2	3	2.125628	0	0.670000	1.870000	0.672196	0.160000	9.000000e-02	0.270000	0.160000	0.181908	0.160000	0	1.200000e-01	2.100000e-01
ZFR	51663	broad.mit.edu	37	5	32364367	32364367	+	Silent	SNP	T	T	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr5:32364367T>C	ENST00000265069.8	-	18	2952	c.2850A>G	c.(2848-2850)ctA>ctG	p.L950L	ZFR_ENST00000510369.1_5'UTR	NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein			32					CTTTCTCTACTAGTAACTCCA	0.343000																								0							SO:0001819	synonymous_variant			ENST00000265069.8	1	1	hg19	CCDS34139.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	ZFR-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000366586.1	1	0	1	140	225	0	44	1	1	52	104	0	44	2		0	0	0	0	0	2	1	1.000000	140	223	0	44	2								-20.000000	1	1	0	0		1	0	1	1	2.079448	0	0.670000	1.870000	0.668891	0.990000	9.800000e-01	1.000000	1.000000	0.999181	0.990000	1	9.900000e-01	1
EGFLAM	133584	broad.mit.edu	37	5	38337656	38337656	+	Silent	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr5:38337656C>T	ENST00000354891.3	+	2	478	c.132C>T	c.(130-132)ggC>ggT	p.G44G	EGFLAM_ENST00000322350.5_Silent_p.G44G	NM_001205301.1	NP_001192230.1	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains			85	all_lung(31;0.000385)				TCAAGCTGGGCGCATTGAACT	0.512000													Colon(62;485 1295 3347 17454)											0							SO:0001819	synonymous_variant			ENST00000354891.3	1	1	hg19	CCDS56363.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	EGFLAM-004	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000367323.1	1	0	1	13	50	0	10	0	6.501796e-01	0	10	0	10	2		0	0	0	0	0	2	1	0.999660	13	48	0	10	2								-19.999950	1	1	121374	1	25	1	1	2	3	2.114355	0	0.670000	1.870000	0.671102	0.620000	3.600000e-01	0.960000	0.620000	0.639235	0.620000	0	4.800000e-01	7.900000e-01
ADAMTS16	170690	broad.mit.edu	37	5	5303737	5303737	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr5:5303737G>A	ENST00000274181.7	+	20	3182	c.3044G>A	c.(3043-3045)aGc>aAc	p.S1015N		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16			107					GCCTGTAAGAGCACCAACCCC	0.627000																								0							SO:0001583	missense			ENST00000274181.7	1	1	hg19	CCDS43299.1	.	.	.	.	.	.	.	.	.	.	G	18.74	3.689063	0.68271	.	.	ENSG00000145536	ENST00000274181	T	0.55234	0.53	4.65	3.78	0.43462	.	0.049330	0.85682	D	0.000000	T	0.45236	0.1332	L	0.40543	1.245	0.38037	D	0.93534	B;P	0.35033	0.241;0.481	B;B	0.41088	0.244;0.347	T	0.36696	-0.9737	10	0.17832	T	0.49	.	10.7639	0.46281	0.0945:0.0:0.9055:0.0	.	1015;1015	Q8TE57;Q8TE57-2	ATS16_HUMAN;.	N	1015	ENSP00000274181:S1015N	ENSP00000274181:S1015N	S	+	2	0	ADAMTS16	5356737	1.000000	0.71417	1.000000	0.80357	0.817000	0.46193	3.713000	0.54882	1.069000	0.40788	0.650000	0.86243	AGC		TCGA-F2-6879-01A-11D-2154-08	ADAMTS16-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000365657.1	0	0	0	10	246	0	44	0	1.975397e-03	0	2	0	44	2		0	0	0	0	0	2	1	0.996596	10	239	0	44	2								-11.737130	1	1	0	0		1	0	1	1	2.079448	0	0.670000	1.870000	0.668891	0.110000	5.000000e-02	0.200000	0.120000	0.126600	0.110000	0	8.000000e-02	1.600000e-01
TCTE1	202500	broad.mit.edu	37	6	44254103	44254103	+	Silent	SNP	G	G	A	rs146051785		TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr6:44254103G>A	ENST00000371505.4	-	3	566	c.444C>T	c.(442-444)ggC>ggT	p.G148G	RP11-444E17.6_ENST00000505802.1_Intron|TCTE1_ENST00000371503.3_5'UTR|TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371504.1_5'Flank	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1			34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		TCCAGCTGCCGCCATGGTGGG	0.607000																								0							SO:0001819	synonymous_variant			ENST00000371505.4	1	1	hg19	CCDS4910.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	TCTE1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000040736.1	1	0	0	221	291	0	29		0	0	0	0	29	2		0	0	0	0	0	2	1	1.000000	218	286	0	28	2								-20.000000	1	1	121412	6	39	1	1	2	3	2.443262	1	0.670000	1.870000	0.709852	0.990000	9.900000e-01	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
RIMS1	22999	broad.mit.edu	37	6	73043409	73043409	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr6:73043409G>A	ENST00000521978.1	+	29	4237	c.4237G>A	c.(4237-4239)Ggc>Agc	p.G1413S	RIMS1_ENST00000401910.3_Missense_Mutation_p.G733S|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000491071.2_Missense_Mutation_p.G1236S|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000538414.1_Missense_Mutation_p.G219S|RIMS1_ENST00000348717.5_Missense_Mutation_p.G1196S|RIMS1_ENST00000517960.1_Missense_Mutation_p.G1196S|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000264839.7_Missense_Mutation_p.G1262S	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1			102		all_epithelial(107;0.179)|all_hematologic(105;0.212)			GCATAATGACGGCAGCCAGTC	0.522000																								0							SO:0001583	missense			ENST00000521978.1	0	1	hg19	CCDS47449.1	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	.|.	G|G	35|35	5.444142|5.444142	0.96187|0.96187	.|.	.|.	ENSG00000079841|ENSG00000079841	ENST00000491071;ENST00000350827;ENST00000352008;ENST00000348717;ENST00000264839;ENST00000517960;ENST00000521978;ENST00000401910;ENST00000453976;ENST00000370420;ENST00000538414|ENST00000517433	T;T;T;T;T;T;T;T;T|.	0.22945|.	2.22;2.42;2.34;2.42;2.26;2.34;2.23;1.94;1.93|.	5.66|5.66	5.66|5.66	0.87406|0.87406	.|.	0.000000|.	0.64402|.	D|.	0.000004|.	T|T	0.64821|0.64821	0.2633|0.2633	L|L	0.50333|0.50333	1.59|1.59	0.80722|0.80722	D|D	1|1	D;D;D;D;D;D;D|.	0.89917|.	0.999;1.0;0.985;1.0;1.0;1.0;1.0|.	D;D;P;D;D;D;D|.	0.91635|.	0.94;0.996;0.681;0.998;0.999;0.999;0.994|.	T|T	0.58825|0.58825	-0.7568|-0.7568	10|5	0.62326|.	D|.	0.03|.	-22.5976|-22.5976	20.1225|20.1225	0.97967|0.97967	0.0:0.0:1.0:0.0|0.0:0.0:1.0:0.0	.|.	219;1262;733;1196;489;1236;1413|.	B7Z7W2;E9PHR1;E9PF48;E7ENC2;Q5JY21;C9JNW6;Q86UR5|.	.;.;.;.;.;.;RIMS1_HUMAN|.	S|Q	1236;1262;1236;1196;1262;1196;1413;733;578;461;219|758	ENSP00000430101:G1236S;ENSP00000275037:G1196S;ENSP00000264839:G1262S;ENSP00000429959:G1196S;ENSP00000428417:G1413S;ENSP00000385649:G733S;ENSP00000389503:G578S;ENSP00000359448:G461S;ENSP00000439730:G219S|.	ENSP00000264839:G1262S|.	G|R	+|+	1|2	0|0	RIMS1|RIMS1	73100130|73100130	1.000000|1.000000	0.71417|0.71417	0.987000|0.987000	0.45799|0.45799	0.994000|0.994000	0.84299|0.84299	9.813000|9.813000	0.99286|0.99286	2.831000|2.831000	0.97527|0.97527	0.650000|0.650000	0.86243|0.86243	GGC|CGG		TCGA-F2-6879-01A-11D-2154-08	RIMS1-011	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000374968.1	1	0	1	17	21	0	11		0	0	0	0	11	2		0	0	0	0	0	2	1	0.999995	17	21	0	10	2								-20.000000	1	1	0	0		1	0	1	1	1.412667	1	0.670000	1.870000	0.503759	0.820000	5.600000e-01	0.990000	0.870000	0.819524	0.820000	0	6.900000e-01	9.400000e-01
ZFPM2	23414	broad.mit.edu	37	8	106815014	106815014	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr8:106815014C>T	ENST00000407775.2	+	8	2954	c.2704C>T	c.(2704-2706)Cga>Tga	p.R902*	ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000378472.4_Nonsense_Mutation_p.R633*|ZFPM2_ENST00000517361.1_Nonsense_Mutation_p.R770*|ZFPM2_ENST00000520492.1_Nonsense_Mutation_p.R770*|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	p.R902*(1)		99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)		AGAAAGCGAACGAAACAGCCC	0.458000																								1	Substitution - Nonsense(1)						SO:0001587	stop_gained			ENST00000407775.2	0	1	hg19	CCDS47908.1	.	.	.	.	.	.	.	.	.	.	C	37	5.984063	0.97173	.	.	ENSG00000169946	ENST00000407775;ENST00000520492;ENST00000517361;ENST00000378472	.	.	.	5.57	3.73	0.42828	.	0.176149	0.51477	D	0.000099	.	.	.	.	.	.	0.80722	D	1	.	.	.	.	.	.	.	.	.	.	0.07644	T	0.81	.	14.4956	0.67685	0.5405:0.4595:0.0:0.0	.	.	.	.	X	902;770;770;633	.	ENSP00000367733:R633X	R	+	1	2	ZFPM2	106884190	1.000000	0.71417	0.973000	0.42090	0.869000	0.49853	1.600000	0.36762	0.663000	0.31027	-0.284000	0.09977	CGA		TCGA-F2-6879-01A-11D-2154-08	ZFPM2-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000380614.1	1	0	0	41	109	0	15	0	9.706830e-01	0	18	0	15	2		0	0	0	0	0	2	1	1.000000	41	106	0	15	2								-20.000000	1	1	0	0		1	1	2	3	2.726968	1	0.670000	1.870000	0.750303	0.990000	8.100000e-01	1.000000	1.000000	0.977886	0.990000	1	9.400000e-01	1
TRHR	7201	broad.mit.edu	37	8	110131289	110131289	+	Silent	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr8:110131289C>T	ENST00000518632.1	+	3	1153	c.802C>T	c.(802-804)Ctg>Ttg	p.L268L	TRHR_ENST00000311762.2_Silent_p.L268L			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor			37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)		CACCAAGATGCTGGCAGTGGT	0.418000																								0							SO:0001819	synonymous_variant			ENST00000518632.1	1	1	hg19	CCDS6311.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	TRHR-002	KNOWN	alternative_5_UTR|not_organism_supported|basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000380892.1	1	0	1	477	1485	0	131		0	0	0	0	131	2		0	0	0	0	0	2	1	1.000000	461	1448	0	128	2								-20.000000	1	1	0	0		1	1	2	3	2.726968	1	0.670000	1.870000	0.750303	0.950000	8.700000e-01	1.000000	1.000000	0.957841	0.950000	1	9.100000e-01	1
KLHL38	340359	broad.mit.edu	37	8	124664206	124664206	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr8:124664206G>A	ENST00000325995.7	-	1	984	c.961C>T	c.(961-963)Cgg>Tgg	p.R321W	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38			38					TTGTACAGCCGTGTCGGGAGT	0.592000																								0							SO:0001583	missense			ENST00000325995.7	1	1	hg19	CCDS43766.1	.	.	.	.	.	.	.	.	.	.	G	12.56	1.974222	0.34848	2.48E-4	1.2E-4	ENSG00000175946	ENST00000325995	T	0.67523	-0.27	5.18	4.3	0.51218	Kelch-type beta propeller (1);	0.000000	0.85682	D	0.000000	T	0.78597	0.4308	M	0.81802	2.56	0.52501	D	0.999951	D	0.71674	0.998	P	0.60949	0.881	T	0.79978	-0.1575	10	0.49607	T	0.09	.	11.7522	0.51855	0.0:0.1336:0.7277:0.1387	.	321	Q2WGJ6	KLH38_HUMAN	W	321	ENSP00000321475:R321W	ENSP00000321475:R321W	R	-	1	2	KLHL38	124733387	1.000000	0.71417	0.702000	0.30337	0.211000	0.24417	5.438000	0.66550	1.290000	0.44636	-0.314000	0.08810	CGG		TCGA-F2-6879-01A-11D-2154-08	KLHL38-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000381288.1	1	0	1	112	322	0	21		0	0	0	0	21	2		0	0	0	0	0	2	1	1.000000	111	319	0	21	2								-3.319442	1	1	120944	12	43	1	1	2	3	2.726968	1	0.670000	1.870000	0.750303	0.990000	8.500000e-01	1.000000	1.000000	0.977237	0.990000	1	9.300000e-01	1
MSR1	4481	broad.mit.edu	37	8	15967630	15967630	+	Silent	SNP	T	T	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			T	C	T	T		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr8:15967630T>C	ENST00000262101.5	-	10	1441	c.1320A>G	c.(1318-1320)tcA>tcG	p.S440S	MSR1_ENST00000350896.3_Silent_p.S377S|MSR1_ENST00000355282.2_Silent_p.S377S|MSR1_ENST00000445506.2_Silent_p.S458S			P21757	MSRE_HUMAN	macrophage scavenger receptor 1			37					CTTCAGAATGTGAACAGGCTC	0.378000																								0							SO:0001819	synonymous_variant			ENST00000262101.5	1	1	hg19	CCDS5995.1																																																																																				TCGA-F2-6879-01A-11D-2154-08	MSR1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000211627.2	1	0	1	179	161	0	67	0	1	0	42	0	67	2		0	0	0	0	0	2	1	1.000000	179	159	0	66	2								-20.000000	1	1	0	0		1	0	1	1	1.474836	1	0.670000	1.870000	0.506247	0.980000	9.000000e-01	1.000000	1.000000	0.979245	0.980000	1	9.400000e-01	1
TMEM67	91147	broad.mit.edu	37	8	94767364	94767364	+	Splice_Site	SNP	A	A	G			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr8:94767364A>G	ENST00000453321.3	+	1	280	c.222A>G	c.(220-222)cgA>cgG	p.R74R	TMEM67_ENST00000409623.3_5'UTR	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67			41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)		AAGATGCCCGAGGTAAGACGG	0.552000																								0							SO:0001630	splice_region_variant			ENST00000453321.3	1	0	hg19	CCDS6258.2	.	.	.	.	.	.	.	.	.	.	A	11.94	1.787392	0.31593	.	.	ENSG00000164953	ENST00000521517	D	0.92699	-3.09	5.35	0.149	0.14863	.	0.907118	0.09652	N	0.773578	D	0.91129	0.7207	.	.	.	0.80722	D	1	.	.	.	.	.	.	D	0.84821	0.0796	7	0.56958	D	0.05	1.5014	4.9979	0.14249	0.5177:0.1558:0.3265:0.0	.	.	.	.	G	72	ENSP00000430740:R72G	ENSP00000427947:R73G	R	+	1	2	TMEM67	94836540	0.805000	0.28982	0.152000	0.22495	0.824000	0.46624	0.741000	0.26202	-0.097000	0.12307	0.477000	0.44152	AGG		TCGA-F2-6879-01A-11D-2154-08	TMEM67-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000329641.2	1	0	1	289	340	0	84	1	9.994935e-01	5	12	0	84	2		0	0	0	0	0	2	1	1.000000	285	334	0	80	2								-20.000000	1	1	0	0		1	1	2	3	2.726968	1	0.670000	1.870000	0.750303	0.990000	9.900000e-01	1.000000	1.000000	1.000000	0.990000	1	9.900000e-01	1
COL5A1	1289	broad.mit.edu	37	9	137674564	137674564	+	Missense_Mutation	SNP	C	C	T			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08			C	T	C	C		Inconclusive	Somatic	Phase_I	WXS	RNA			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chr9:137674564C>T	ENST00000371817.3	+	29	2896	c.2482C>T	c.(2482-2484)Cgg>Tgg	p.R828W		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1			115		Myeloproliferative disorder(178;0.0341)			CAAGGGTGATCGGGTGAGCAT	0.587000																								0							SO:0001583	missense			ENST00000371817.3	1	1	hg19	CCDS6982.1	2	9.157509157509158E-4	0	0.0	2	0.0055248618784530384	0	0.0	0	0.0	C	18.35	3.605486	0.66445	0.0	1.16E-4	ENSG00000130635	ENST00000371817	D	0.97041	-4.22	4.18	3.11	0.35812	.	0.064543	0.64402	U	0.000016	D	0.97300	0.9117	M	0.85859	2.78	0.58432	D	0.999998	D	0.89917	1.0	D	0.83275	0.996	D	0.95502	0.8578	10	0.72032	D	0.01	.	8.9457	0.35758	0.4494:0.5506:0.0:0.0	.	828	P20908	CO5A1_HUMAN	W	828	ENSP00000360882:R828W	ENSP00000360882:R828W	R	+	1	2	COL5A1	136814385	0.811000	0.29063	0.958000	0.39756	0.800000	0.45204	0.973000	0.29422	2.057000	0.61298	0.563000	0.77884	CGG		TCGA-F2-6879-01A-11D-2154-08	COL5A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000054954.2	1	0	1	213	518	0	77	0	1	0	1156	0	77	2		0	0	0	0	0	2	1	1.000000	206	505	0	75	2								-3.318794	1	1	121410	18	47	1	1	2	3	2.164150	0	0.670000	1.870000	0.675436	0.880000	7.800000e-01	1.000000	0.880000	0.889593	0.880000	1	8.300000e-01	9.400000e-01
AFF2	2334	broad.mit.edu	37	X	148037698	148037698	+	Missense_Mutation	SNP	G	G	A			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chrX:148037698G>A	ENST00000370460.2	+	11	2602	c.2123G>A	c.(2122-2124)cGg>cAg	p.R708Q	AFF2_ENST00000370457.5_Missense_Mutation_p.R675Q|AFF2_ENST00000342251.3_Missense_Mutation_p.R675Q|AFF2_ENST00000286437.5_Missense_Mutation_p.R349Q	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2			109	Acute lymphoblastic leukemia(192;6.56e-05)				CCAAAGTCTCGGGAATTCATT	0.488000																								0							SO:0001583	missense			ENST00000370460.2	1	1	hg19	CCDS14684.1	.	.	.	.	.	.	.	.	.	.	G	24.5	4.537272	0.85812	.	.	ENSG00000155966	ENST00000370460;ENST00000370457;ENST00000342251;ENST00000286437	T;T;T;T	0.66460	-0.21;-0.21;-0.21;-0.21	5.67	5.67	0.87782	.	0.059861	0.64402	D	0.000016	D	0.82669	0.5087	M	0.79926	2.475	0.42293	D	0.992149	D;D;D;D;D;D	0.89917	1.0;1.0;1.0;1.0;1.0;1.0	D;D;D;D;D;D	0.71414	0.973;0.954;0.954;0.954;0.954;0.973	T	0.83078	-0.0139	10	0.42905	T	0.14	.	18.7499	0.91810	0.0:0.0:1.0:0.0	.	349;673;675;669;698;708	B4DXD5;P51816-6;P51816-3;P51816-2;P51816-5;P51816	.;.;.;.;.;AFF2_HUMAN	Q	708;675;675;349	ENSP00000359489:R708Q;ENSP00000359486:R675Q;ENSP00000345459:R675Q;ENSP00000286437:R349Q	ENSP00000286437:R349Q	R	+	2	0	AFF2	147845398	1.000000	0.71417	1.000000	0.80357	0.984000	0.73092	5.672000	0.68102	2.372000	0.80975	0.600000	0.82982	CGG		TCGA-F2-6879-01A-11D-2154-08	AFF2-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000058673.2	1	0	1	258	143	0	37	0	4.115634e-01	0	2	0	37	2		0	0	0	0	0	2	1	1.000000	252	140	0	37	2								-20.000000	1	1	0	0		1	0	1	1			0.670000	1.870000	0.670000	0.940000	8.800000e-01	1.000000	0.960000	0.951150	0.940000	1	9.100000e-01	9.800000e-01
CXorf21	80231	broad.mit.edu	37	X	30577625	30577625	+	Missense_Mutation	SNP	A	A	C			TCGA-F2-6879-01A-11D-2154-08	TCGA-F2-6879-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ddd3f83-28a8-4b7f-9aec-203a3c2efbe5	c043e276-fece-4cb9-a848-a0b16e6099b6	g.chrX:30577625A>C	ENST00000378962.3	-	3	1170	c.848T>G	c.(847-849)aTt>aGt	p.I283S		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21			20					AATTTCAGTAATTTCAGTTGA	0.383000																								0							SO:0001583	missense			ENST00000378962.3	0	1	hg19	CCDS14224.1	.	.	.	.	.	.	.	.	.	.	A	7.306	0.613922	0.14066	.	.	ENSG00000120280	ENST00000378962	.	.	.	5.11	5.11	0.69529	.	0.662303	0.11137	U	0.595712	T	0.35913	0.0948	N	0.12182	0.205	0.33979	D	0.647716	P	0.49783	0.928	P	0.49226	0.603	T	0.08046	-1.0741	9	0.02654	T	1	.	13.9975	0.64411	1.0:0.0:0.0:0.0	.	283	Q9HAI6	CX021_HUMAN	S	283	.	ENSP00000368245:I283S	I	-	2	0	CXorf21	30487546	1.000000	0.71417	0.999000	0.59377	0.772000	0.43724	8.322000	0.90000	1.880000	0.54463	0.417000	0.27973	ATT		TCGA-F2-6879-01A-11D-2154-08	CXorf21-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056164.1	0	0	0	5	205	0	24	0	1.262471e-02	0	6	0	24	2		0	0	0	0	0	2	1	0.935095	5	201	0	24	2								-7.111466	1	0	0	0		1	0	1	1			0.670000	1.870000	0.670000	0.030000	0	0.080000	0.040000	0.042134	0.030000	0	2.000000e-02	6.000000e-02
