Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTENP1	0	broad.mit.edu	37	9	33675379	33675379	+	RNA	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr9:33675379C>A	ENST00000532280.1	-	0	2118					NR_023917.1																						AAAAAGGTCCCTTTTCAGTTT	0.318000													3	33					0.115264	0.115264	1	1	0
CWF19L1	55280	broad.mit.edu	37	10	101993060	101993060	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr10:101993060C>T	ENST00000354105.4	-	14	1627	c.1541G>A	c.(1540-1542)aGc>aAc	p.S514N	CWF19L1_ENST00000478047.1_5'UTR|CWF19L1_ENST00000370379.1_Missense_Mutation_p.S229N|RP11-316M21.6_ENST00000444359.1_RNA	NM_018294.4	NP_060764.3	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control (S. pombe)	514							catalytic activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|stomach(2)	17		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		GTCTTCCTTGCTGATCTGACA	0.473000													10	61					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39382336	39382336	+	Missense_Mutation	SNP	A	A	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr22:39382336A>G	ENST00000402182.3	+	4	543	c.488A>G	c.(487-489)aAt>aGt	p.N163S	APOBEC3B_ENST00000407298.3_Missense_Mutation_p.N163S|APOBEC3B_ENST00000333467.3_Missense_Mutation_p.N163S			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	163					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					TTTGTGTACAATGAAGGTCAG	0.512000													35	131					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26446395	26446395	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr10:26446395C>T	ENST00000265944.5	+	26	3116	c.2950C>T	c.(2950-2952)Cga>Tga	p.R984*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	984	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R984*(3)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAAGAATTCGAAGACTAGG	0.363000													20	73					0	0	1	0	0
PPP2CA	5515	broad.mit.edu	37	5	133541656	133541656	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr5:133541656C>T	ENST00000481195.1	-	2	549	c.269G>A	c.(268-270)gGa>gAa	p.G90E	CDKL3_ENST00000518409.1_5'UTR|PPP2CA_ENST00000231504.5_5'UTR	NM_002715.2	NP_002706.1			protein phosphatase 2, catalytic subunit, alpha isozyme											endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAATAATATCCTCTGTCAAC	0.368000													10	34					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28212235	28212235	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr21:28212235C>T	ENST00000284984.2	-	6	2265	c.1811G>A	c.(1810-1812)cGc>cAc	p.R604H		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	604	TSP type-1 1.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		GGATCTGTAGCGCACTCGTTT	0.473000													5	112					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76028613	76028613	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr5:76028613C>T	ENST00000319211.4	+	2	828	c.563C>T	c.(562-564)gCc>gTc	p.A188V		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	188					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	AACATGTACGCCTCTATCTTG	0.493000													11	129					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156849884	156849884	+	Missense_Mutation	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr1:156849884G>A	ENST00000368196.3	+	15	2242	c.2122G>A	c.(2122-2124)Ggc>Agc	p.G708S	NTRK1_ENST00000524377.1_Missense_Mutation_p.G714S|NTRK1_ENST00000531606.1_3'UTR|NTRK1_ENST00000358660.3_Missense_Mutation_p.G711S|NTRK1_ENST00000392302.2_Missense_Mutation_p.G678S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	714	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GTGGAGCTTCGGCGTGGTGCT	0.647000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			3	71					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92164118	92164118	+	Missense_Mutation	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr7:92164118G>A	ENST00000481551.1	+	4	892	c.851G>A	c.(850-852)cGc>cAc	p.R284H	RBM48_ENST00000265732.5_Missense_Mutation_p.R284H			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	284							nucleotide binding	p.R284H(1)									CTGCAGGAGCGCAAAAGAAGA	0.428000													3	41					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55713580	55713580	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr19:55713580C>T	ENST00000376350.3	-	6	1019	c.997G>A	c.(997-999)Gag>Aag	p.E333K	PTPRH_ENST00000263434.5_Missense_Mutation_p.E155K|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	333	Fibronectin type-III 4.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCAGTGTACTCAACCCCGTAG	0.567000													4	73					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828504	76828504	+	Missense_Mutation	SNP	G	G	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr7:76828504G>T	ENST00000248598.5	-	1	639	c.607C>A	c.(607-609)Cgt>Agt	p.R203S	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	203					signal transduction	fibrinogen complex	receptor binding	p.R203S(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						ATACCTGGACGTGACTGTATT	0.323000													5	87					0.000602214	0.000655745	1	1	0
SSX7	280658	broad.mit.edu	37	X	52681974	52681974	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chrX:52681974C>A	ENST00000298181.5	-	3	288	c.130G>T	c.(130-132)Gag>Tag	p.E44*		NM_173358.2	NP_775494.1	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	44	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|skin(1)	16	Ovarian(276;0.236)					CTGATTTTCTCCAAGGATTTC	0.383000													27	56					8.88839e-20	1.08883e-19	1	1	0
PSG8	0	broad.mit.edu	37	19	43268205	43268205	+	Missense_Mutation	SNP	C	C	T	rs142736244	by1000genomes	TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr19:43268205C>T	ENST00000404209.4	-	2	389	c.293G>A	c.(292-294)cGa>cAa	p.R98Q	PSG8_ENST00000406636.3_Intron|PSG8_ENST00000401467.2_Missense_Mutation_p.R98Q|PSG8_ENST00000306511.4_Missense_Mutation_p.R98Q	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	98	Ig-like V-type.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TATTGTTTCTCGTCCACTGTA	0.423000													7	308					0	0	1	0	0
NET1	10276	broad.mit.edu	37	10	5493864	5493864	+	Missense_Mutation	SNP	A	A	C			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr10:5493864A>C	ENST00000355029.4	+	4	469	c.327A>C	c.(325-327)agA>agC	p.R109S	NET1_ENST00000380359.3_Missense_Mutation_p.R55S|NET1_ENST00000542715.1_5'UTR	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	109					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						CTCCTGTAAGAAATGGAGCTG	0.403000													15	103					0	0	1	0	0
CWF19L1	55280	broad.mit.edu	37	10	101993058	101993058	+	Nonsense_Mutation	SNP	T	T	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr10:101993058T>A	ENST00000354105.4	-	14	1629	c.1543A>T	c.(1543-1545)Aag>Tag	p.K515*	CWF19L1_ENST00000478047.1_5'UTR|CWF19L1_ENST00000370379.1_Nonsense_Mutation_p.K230*|RP11-316M21.6_ENST00000444359.1_RNA	NM_018294.4	NP_060764.3	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control (S. pombe)	515							catalytic activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|stomach(2)	17		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		TCGTCTTCCTTGCTGATCTGA	0.473000													10	60					0	0	1	0	0
FSHR	0	broad.mit.edu	37	2	49190290	49190290	+	Missense_Mutation	SNP	C	C	T	rs150235567		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr2:49190290C>T	ENST00000406846.2	-	10	1789	c.1670G>A	c.(1669-1671)cGg>cAg	p.R557Q	FSHR_ENST00000346173.3_Missense_Mutation_p.R495Q|FSHR_ENST00000541117.1_Missense_Mutation_p.R293Q|FSHR_ENST00000304421.4_Missense_Mutation_p.R531Q	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	557					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GTTGGGGTTCCGCACTGTGAG	0.527000									Gonadal Dysgenesis, 46 XX				4	28					0	0	1	0	0
IFT74	80173	broad.mit.edu	37	9	27062709	27062709	+	Missense_Mutation	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr9:27062709C>A	ENST00000443698.1	+	20	1949	c.1778C>A	c.(1777-1779)gCt>gAt	p.A593D	IFT74_ENST00000380062.5_Missense_Mutation_p.A593D|IFT74_ENST00000433700.1_Missense_Mutation_p.A593D	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	593						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		ATCGTGGATGCTTTACATAGC	0.388000													3	62					6.4e-05	7.29302e-05	1	1	0
SNX16	64089	broad.mit.edu	37	8	82727590	82727590	+	Silent	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr8:82727590C>A	ENST00000396330.2	-	6	1157	c.651G>T	c.(649-651)ccG>ccT	p.P217P	SNX16_ENST00000353788.4_Silent_p.P188P|SNX16_ENST00000345957.4_Silent_p.P217P|RP13-923O23.6_ENST00000524337.1_RNA	NM_022133.3	NP_071416.2	P57768	SNX16_HUMAN	sorting nexin 16	217	PX.				cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			large_intestine(1)|ovary(1)|pancreas(1)|skin(2)	5						CAAATGGACCCGGTGGATCAT	0.338000													6	36					1.06961e-07	1.27832e-07	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85518199	85518199	+	Silent	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr12:85518199G>A	ENST00000393217.2	+	17	3970	c.3909G>A	c.(3907-3909)aaG>aaA	p.K1303K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1303										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		AAGACAGCAAGGCAAGCAGTA	0.398000													12	159					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186386777	186386777	+	Silent	SNP	G	G	A	rs143118011	by1000genomes	TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr3:186386777G>A	ENST00000232003.4	+	2	317	c.237G>A	c.(235-237)tcG>tcA	p.S79S		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	79	Cystatin 1.|Interaction with ATP5A1.		S -> L (in dbSNP:rs4516605).		fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CGGACTGTTCGGTCCTATCCA	0.428000													4	70					0	0	1	0	0
EVI2A	2123	broad.mit.edu	37	17	29645857	29645857	+	Missense_Mutation	SNP	T	T	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr17:29645857T>G	ENST00000247270.3	-	3	580	c.244A>C	c.(244-246)Att>Ctt	p.I82L	NF1_ENST00000581113.2_Intron|NF1_ENST00000358273.4_Intron|NF1_ENST00000356175.3_Intron|EVI2A_ENST00000462804.2_Missense_Mutation_p.I59L|EVI2A_ENST00000461237.1_Missense_Mutation_p.I59L	NM_001003927.2	NP_001003927.1	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A	59						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		TTTGTGTTAATGTTTTCATTT	0.368000													5	108					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176852023	176852023	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr1:176852023G>A	ENST00000367654.2	-	20	3371	c.3358C>T	c.(3358-3360)Cga>Tga	p.R1120*	ASTN1_ENST00000424564.2_Nonsense_Mutation_p.R1112*|ASTN1_ENST00000361833.2_Nonsense_Mutation_p.R1112*|ASTN1_ENST00000367657.3_Nonsense_Mutation_p.R1112*			O14525	ASTN1_HUMAN	astrotactin 1	1120	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TCCAGGCATCGTATGATCAGA	0.502000													8	38					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	33					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14883284	14883284	+	Silent	SNP	C	C	T	rs146183015	byFrequency	TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr19:14883284C>T	ENST00000315576.3	-	5	676	c.225G>A	c.(223-225)tcG>tcA	p.S75S	EMR2_ENST00000594294.1_Silent_p.S75S|EMR2_ENST00000346057.1_Silent_p.S75S|EMR2_ENST00000595839.1_Silent_p.S75S|EMR2_ENST00000596991.2_Silent_p.S75S|EMR2_ENST00000599423.1_5'UTR|EMR2_ENST00000594076.1_Silent_p.S75S|EMR2_ENST00000353876.1_Silent_p.S75S|EMR2_ENST00000392965.3_Silent_p.S75S|EMR2_ENST00000392967.2_Silent_p.S75S|EMR2_ENST00000353005.1_Silent_p.S75S|EMR2_ENST00000601345.1_Silent_p.S75S	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	75	EGF-like 2; calcium-binding.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						ATGACACTTTCGACAGTGTTG	0.537000													8	47					0	0	1	0	0
ULBP1	80329	broad.mit.edu	37	6	150289967	150289967	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr6:150289967C>T	ENST00000229708.2	+	2	353	c.310C>T	c.(310-312)Caa>Taa	p.Q104*	ULBP1_ENST00000367345.1_Nonsense_Mutation_p.Q104*	NM_025218.2	NP_079494.1	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1	104	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			large_intestine(3)|lung(5)|pancreas(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		CCTTAAAGGGCAACTGCTTGA	0.413000													16	64					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167545362	167545362	+	Missense_Mutation	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr5:167545362G>A	ENST00000519204.1	+	9	1634	c.1516G>A	c.(1516-1518)Ggc>Agc	p.G506S	TENM2_ENST00000403607.2_Missense_Mutation_p.G460S|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000518659.1_Missense_Mutation_p.G627S|TENM2_ENST00000520394.1_Missense_Mutation_p.G395S|TENM2_ENST00000545108.1_Missense_Mutation_p.G627S					teneurin transmembrane protein 2																		GTGCTACAGCGGCTGGAAAGG	0.567000													33	95					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121880305	121880305	+	Missense_Mutation	SNP	T	T	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr12:121880305T>G	ENST00000377069.4	-	18	3138	c.2732A>C	c.(2731-2733)gAg>gCg	p.E911A	KDM2B_ENST00000542973.1_Missense_Mutation_p.E348A|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.E980A	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	980					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CTCCTCGCCCTCGCTCTCAGG	0.682000													12	21					0	0	1	0	0
RP11-481J13.1	0	broad.mit.edu	37	2	56216130	56216130	+	RNA	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr2:56216130C>A	ENST00000606639.1	+	0	82				AC011306.2_ENST00000446139.1_lincRNA|MIR216A_ENST00000385063.1_RNA																							TCCCAGAGACCACTGTGAGGG	0.433000													4	140					0.014758	0.015386	1	1	0
INSRR	3645	broad.mit.edu	37	1	156821758	156821758	+	Missense_Mutation	SNP	C	C	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr1:156821758C>G	ENST00000368195.3	-	3	1259	c.863G>C	c.(862-864)gGc>gCc	p.G288A	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	288					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGAGGCACGGCCGGGCACAGA	0.662000													7	23					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10668457	10668457	+	Missense_Mutation	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr19:10668457C>T	ENST00000312962.6	-	15	1511	c.1492G>A	c.(1492-1494)Gtg>Atg	p.V498M	KRI1_ENST00000361821.5_Missense_Mutation_p.V494M	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	498										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGTTCAAACACGGGCTTCTCC	0.701000													4	36					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685748	125685748	+	Silent	SNP	A	A	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chrX:125685748A>G	ENST00000371126.1	-	1	1086	c.844T>C	c.(844-846)Ttg>Ctg	p.L282L		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	282										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						TAGCCGTCCAAGGACACCGCT	0.627000													14	17					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599145	136599145	+	Missense_Mutation	SNP	T	T	C			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr6:136599145T>C	ENST00000531224.1	-	4	1126	c.874A>G	c.(874-876)Att>Gtt	p.I292V	BCLAF1_ENST00000527759.1_Missense_Mutation_p.I290V|BCLAF1_ENST00000527536.1_Missense_Mutation_p.I292V|BCLAF1_ENST00000392348.2_Missense_Mutation_p.I290V|BCLAF1_ENST00000530767.1_Missense_Mutation_p.I292V|BCLAF1_ENST00000353331.4_Missense_Mutation_p.I290V	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	292					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATGTGATGAATTGGACTATTC	0.463000													5	73					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4317416	4317416	+	Missense_Mutation	SNP	A	A	G			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr4:4317416A>G	ENST00000337872.4	+	6	1551	c.1430A>G	c.(1429-1431)aAa>aGa	p.K477R	ZBTB49_ENST00000355834.3_Intron|ZBTB49_ENST00000538529.1_5'UTR	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						TCAGGAGAAAAACCACACTTG	0.398000													7	37					0	0	1	0	0
DMRT1	1761	broad.mit.edu	37	9	916850	916850	+	Missense_Mutation	SNP	G	G	A	rs141672484		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr9:916850G>A	ENST00000382276.3	+	4	1059	c.910G>A	c.(910-912)Gtg>Atg	p.V304M	DMRT1_ENST00000569227.1_Missense_Mutation_p.V146M	NM_021951.2	NP_068770.2	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor 1	304					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(10)|ovary(1)	13		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		GGGCCAGAGCGTGCCCCAGTT	0.542000													9	30					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31066655	31066655	+	Silent	SNP	C	C	T			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr14:31066655C>T	ENST00000206595.6	+	7	712	c.558C>T	c.(556-558)ttC>ttT	p.F186F	G2E3_ENST00000553504.1_Silent_p.F216F|G2E3_ENST00000438909.2_Silent_p.F140F|G2E3_ENST00000544007.1_3'UTR	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	186					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						GAGTGTTTTTCTTTAGGTGTA	0.313000													17	112					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165551251	165551251	+	Missense_Mutation	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr2:165551251G>A	ENST00000375458.2	-	11	2872	c.2651C>T	c.(2650-2652)gCt>gTt	p.A884V	COBLL1_ENST00000342193.4_Missense_Mutation_p.A922V|COBLL1_ENST00000392717.2_Missense_Mutation_p.A960V|COBLL1_ENST00000194871.6_Missense_Mutation_p.A989V|COBLL1_ENST00000409184.3_Missense_Mutation_p.A922V	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	960										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						ACTCTTGGCAGCTGCAGATGT	0.468000													3	40					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867774	29867774	+	Silent	SNP	G	G	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr18:29867774G>A	ENST00000399218.4	-	4	841	c.786C>T	c.(784-786)ctC>ctT	p.L262L	RP11-344B2.2_ENST00000579580.1_RNA|GAREM_ENST00000269209.6_Silent_p.L262L	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GGATGAAGTGGAGGTCGTATG	0.542000													5	52					0	0	1	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671564	112671564	+	Silent	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr6:112671564C>A	ENST00000441065.2	+	3	966	c.654C>A	c.(652-654)atC>atA	p.I218I		NM_001013734.2	NP_001013756.2	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	218	B30.2/SPRY.						zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	14		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		TAGAAGAAATCCAGTTTTTTG	0.458000													7	46					3.09899e-07	3.61548e-07	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118526457	118526457	+	Missense_Mutation	SNP	T	T	C			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr1:118526457T>C	ENST00000336338.5	-	42	5914	c.5849A>G	c.(5848-5850)cAa>cGa	p.Q1950R	SPAG17_ENST00000492438.1_5'UTR	NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1950						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AGATGTATCTTGAACAGCTGT	0.333000													3	30					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40761496	40761496	+	Missense_Mutation	SNP	C	C	A			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr12:40761496C>A	ENST00000298910.7	+	51	7571	c.7513C>A	c.(7513-7515)Caa>Aaa	p.Q2505K		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2505					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ACATGAAGTGCAAAATTTAGA	0.323000													7	66					0.00448238	0.00477471	1	1	0
LIPC	3990	broad.mit.edu	37	15	58830668	58830668	+	Silent	SNP	C	C	T	rs146362585	by1000genomes	TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr15:58830668C>T	ENST00000414170.3	+	3	512	c.225C>T	c.(223-225)tgC>tgT	p.C75C	LIPC_ENST00000433326.2_Silent_p.C75C|LIPC_ENST00000356113.6_Silent_p.C75C|LIPC_ENST00000299022.5_Silent_p.C75C			P11150	LIPC_HUMAN	lipase, hepatic	75					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity	p.C75C(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TACAGGAGTGCGGCTTCAACT	0.473000													4	139					0	0	1	0	0
AC079776.3	0	broad.mit.edu	37	2	130697404	130697404	+	RNA	DEL	T	T	-			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr2:130697404delT	ENST00000450840.1	+	0	346																											ATACAAAATATTCCAGATAAA	0.358													2	4	---	---	---	---					
LRIG1	26018	broad.mit.edu	37	3	66433531	66433531	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr3:66433531delT	ENST00000383703.3	-	16	2900	c.2297delA	c.(2296-2298)gtfs	p.D766fs	LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_Frame_Shift_Del_p.D789fs|SLC25A26_ENST00000536651.1_Intron			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	789	Ig-like C2-type 3.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CGTGGTCCCATCCTTCCTGCA	0.597													36	99	---	---	---	---					
OTOP1	133060	broad.mit.edu	37	4	4228274	4228282	+	In_Frame_Del	DEL	CCACAGCAG	CCACAGCAG	-	rs111245977		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr4:4228274_4228282delCCACAGCAG	ENST00000296358.4	-	1	334_342	c.310_318delCTGCTGTGG	c.(310-318)del	p.LLW104del		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	104					biomineral tissue development	extracellular space|integral to membrane		p.L104_W106delLLW(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACAGCATCCACAGCAGCTGCAGCAGC	0.727													6	7	---	---	---	---					
TREML2	79865	broad.mit.edu	37	6	41166145	41166163	+	Frame_Shift_Del	DEL	GTATACACTGTCAGCAGAG	GTATACACTGTCAGCAGAG	-	rs77704965	byFrequency	TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr6:41166145_41166163delGTATACACTGTCAGCAGAG	ENST00000483722.1	-	2	245_263	c.60_78delCTCTGCTGACAGTGTATAC	c.(58-78)ccfs	p.PSADSVY20fs		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	20	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCACTTTTGTGTATACACTGTCAGCAGAGGGGCCTGTGG	0.470													9	117	---	---	---	---					
FAM66D	0	broad.mit.edu	37	8	11994579	11994580	+	RNA	DEL	TG	TG	-			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr8:11994579_11994580delTG	ENST00000434078.2	+	0	608					NR_027425.1																						TGTTCgtgtttgtgtgtgtgtg	0.505													2	4	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89720803	89720804	+	Frame_Shift_Del	DEL	TA	TA	-	rs146650273		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr10:89720803_89720804delTA	ENST00000371953.3	+	8	2311_2312	c.954_955delTA	c.(952-957)ctctfs	p.LT320fs	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	320	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.L318fs*2(27)|p.T319fs*1(24)|p.T319fs*6(6)|p.R55fs*1(5)|p.V317fs*3(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.T319del(2)|p.V317fs*6(2)|p.T319_K332del(1)|p.G165_*404del(1)|p.L318fs*3(1)|p.L316fs*1(1)|p.T319fs*4(1)|p.W274_F341del(1)|p.V317_K322del(1)|p.T318fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATCTAGTACTTACTTTAACAAA	0.327		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			14	91	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000502686.2_Intron			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													10	321	---	---	---	---					
MN1	4330	broad.mit.edu	37	22	28194933	28194934	+	In_Frame_Ins	INS	-	-	TGC	rs34890218		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chr22:28194933_28194934insTGC	ENST00000302326.4	-	1	2552_2553	c.1598_1599insGCA	c.(1597-1599)cca>cGCAca	p.533_533P>RT		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	533	Poly-Gln.						binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						gctgctgctgttgctgctgctg	0.653			T	ETV6	"""AML, meningioma"""								5	5	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165595	50165596	+	RNA	INS	-	-	AC	rs59226442		TCGA-4L-AA1F-01A-11D-A41K-08	TCGA-4L-AA1F-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0222802-6dcc-4ec8-a7de-cb26d52f09ee	e3a32f56-a8b5-40ca-a15b-7714da6f0ac7	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													3	5	---	---	---	---					
