Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEACAM3	1084	broad.mit.edu	37	19	42301736	42301736	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr19:42301736G>A	ENST00000357396.3	+	2	521	c.280G>A	c.(280-282)Gca>Aca	p.A94T	CEACAM3_ENST00000595255.1_3'UTR|CEACAM3_ENST00000344550.4_Missense_Mutation_p.A94T|CEACAM3_ENST00000221999.4_Missense_Mutation_p.A94T	NM_001815.2	NP_001806.2	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 3	94	Ig-like V-type.					integral to membrane		p.A94T(1)		endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(3)|skin(4)|stomach(1)	19						CCCAGGGGCCGCATACAGCGG	0.463000													4	219					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110864414	110864414	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr4:110864414T>G	ENST00000265171.5	+	3	777	c.332T>G	c.(331-333)gTa>gGa	p.V111G	EGF_ENST00000502723.1_3'UTR|EGF_ENST00000503392.1_Missense_Mutation_p.V111G|EGF_ENST00000509793.1_Missense_Mutation_p.V111G	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	111					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTGCAGAGAGTATGTAATATA	0.249000													11	35					0	0	1	0	0
CCDC15	80071	broad.mit.edu	37	11	124857123	124857123	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr11:124857123A>G	ENST00000529051.1	+	8	1260	c.1001A>G	c.(1000-1002)gAt>gGt	p.D334G	CCDC15_ENST00000344762.5_Missense_Mutation_p.D334G			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	334						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		GAAGCCCAGGATTATTTTCTA	0.408000													8	60					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45131186	45131186	+	Silent	SNP	C	C	A	rs76419021	by1000genomes	TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr20:45131186C>A	ENST00000457685.2	-	6	2001	c.678G>T	c.(676-678)ccG>ccT	p.P226P	ZNF334_ENST00000593880.1_Silent_p.P287P|ZNF334_ENST00000347606.4_Silent_p.P264P			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TACAAACATACGGTTTCTCCC	0.393000													16	125					1.3612e-06	1.50601e-06	1	1	0
TTN	7273	broad.mit.edu	37	2	179615125	179615125	+	Nonsense_Mutation	SNP	A	A	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr2:179615125A>C	ENST00000360870.5	-	46	12224	c.12002T>G	c.(12001-12003)tTa>tGa	p.L4001*	TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9817							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAAGAGTTAATATTGAATA	0.333000													5	55					0	0	1	0	0
LCE1C	353133	broad.mit.edu	37	1	152777721	152777721	+	Silent	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:152777721G>A	ENST00000368768.1	-	2	284	c.234C>T	c.(232-234)agC>agT	p.S78S	LCE1C_ENST00000607093.1_Silent_p.S78S	NM_178351.3	NP_848128.1	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	78	Gly-rich.				keratinization					NS(1)|lung(4)|prostate(1)|skin(2)|urinary_tract(1)	9	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCTGTGGTGGCTCAGGCAGC	0.706000													8	63					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148895640	148895640	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr3:148895640C>A	ENST00000264613.6	-	17	3267	c.3005G>T	c.(3004-3006)aGc>aTc	p.S1002I		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	1002	F5/8 type A 3.|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	GTATTGGAAGCTATGGCCGTG	0.393000													5	99					0.014758	0.0156615	1	1	0
UTP11L	51118	broad.mit.edu	37	1	38478519	38478519	+	Missense_Mutation	SNP	A	A	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:38478519A>C	ENST00000373014.4	+	1	106	c.45A>C	c.(43-45)gaA>gaC	p.E15D	UTP11L_ENST00000537711.1_Missense_Mutation_p.E15D	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	15					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGCAGCGGGAACACAGAGAGC	0.612000													23	82					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70961830	70961830	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr6:70961830C>T	ENST00000357250.6	-	28	2023	c.1865G>A	c.(1864-1866)gGg>gAg	p.G622E	COL9A1_ENST00000320755.7_Missense_Mutation_p.G379E|COL9A1_ENST00000370499.4_Missense_Mutation_p.G379E|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	622	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CACAGGAAGCCCCTGGGGTCC	0.488000													4	136					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													7	53					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805519	46805519	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr17:46805519A>G	ENST00000290295.7	-	1	1021	c.437T>C	c.(436-438)gTg>gCg	p.V146A		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	146					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						CACCACAGACACGTCCAGGTA	0.607000													16	70					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547138	132547138	+	Silent	SNP	A	A	G	rs35873108	byFrequency	TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr12:132547138A>G	ENST00000333577.4	+	48	8443	c.8334A>G	c.(8332-8334)caA>caG	p.Q2778Q	EP400_ENST00000332482.4_Silent_p.Q2705Q|EP400_ENST00000389561.2_Silent_p.Q2742Q|EP400_ENST00000389562.2_Silent_p.Q2741Q|EP400_ENST00000330386.6_Silent_p.Q2661Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2778	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2741Q(3)|p.Q2742Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcaacagcagcagc	0.602000													3	24					0	0	1	0	0
SFSWAP	6433	broad.mit.edu	37	12	132209998	132209998	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr12:132209998G>A	ENST00000261674.4	+	5	796	c.655G>A	c.(655-657)Gtg>Atg	p.V219M	SFSWAP_ENST00000541286.1_Missense_Mutation_p.V219M	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	219					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						GGCCAGCTTCGTGTGCAGGCA	0.557000													10	48					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115123932	115123932	+	Nonsense_Mutation	SNP	A	A	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:115123932A>C	ENST00000369541.3	-	2	221	c.174T>G	c.(172-174)taT>taG	p.Y58*	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	58					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAAGGCAGAATAATCCGGGG	0.448000													18	178					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47863892	47863892	+	Missense_Mutation	SNP	G	G	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr20:47863892G>C	ENST00000396105.1	-	14	5915	c.5669C>G	c.(5668-5670)gCt>gGt	p.A1890G	ZNFX1_ENST00000371752.1_Missense_Mutation_p.A1890G|ZNFX1_ENST00000371754.4_Intron	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1890							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CATTTCAGAAGCAAGCTGGTT	0.517000													14	42					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324080	152324080	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:152324080G>A	ENST00000388718.5	-	3	6254	c.6182C>T	c.(6181-6183)tCa>tTa	p.S2061L	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2061							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGGATCCTGACTCTCCATG	0.532000													53	485					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587196	55587196	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr11:55587196G>T	ENST00000333976.4	+	1	111	c.91G>T	c.(91-93)Gtt>Ttt	p.V31F		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V31F(1)		NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				ACTCTTCCTGGTTTTTCTGGC	0.458000													4	79					0.184627	0.188247	1	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685212	125685212	+	Silent	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chrX:125685212G>A	ENST00000371126.1	-	1	1622	c.1380C>T	c.(1378-1380)ggC>ggT	p.G460G		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	460										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						AGCTCCAGAGGCCTGCATAGT	0.537000													3	33					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109685642	109685642	+	Translation_Start_Site	SNP	A	A	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr9:109685642A>T	ENST00000277225.5	+	0	267				RP11-508N12.4_ENST00000451160.2_De_novo_Start_OutOfFrame|ZNF462_ENST00000457913.1_De_novo_Start_OutOfFrame			Q96JM2	ZN462_HUMAN	zinc finger protein 462						transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CAGGTTCCTAATGTGAGAGGC	0.448000													5	49					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189702344	189702344	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr3:189702344C>A	ENST00000319332.5	-	7	1421	c.1224G>T	c.(1222-1224)gaG>gaT	p.E408D	LEPREL1_ENST00000427335.2_Missense_Mutation_p.E227D	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	408					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CTTACCGATTCTCATCCTGTC	0.328000													3	44					0.004672	0.00506133	1	1	0
ERI2	112479	broad.mit.edu	37	16	20811285	20811285	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr16:20811285G>A	ENST00000564349.1	-	8	833	c.358C>T	c.(358-360)Cat>Tat	p.H120Y	ERI2_ENST00000389345.5_5'UTR|ERI2_ENST00000300005.3_Missense_Mutation_p.H213Y|ERI2_ENST00000357967.4_Missense_Mutation_p.H213Y|ERI2_ENST00000569729.1_Missense_Mutation_p.H213Y|ERI2_ENST00000563117.1_Missense_Mutation_p.H120Y			A8K979	ERI2_HUMAN	ERI1 exoribonuclease family member 2	213	Exonuclease.					intracellular	exonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(2)	11						TAACCAGAATGTTCTCGTCCT	0.294000													4	43					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21826345	21826345	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:21826345A>G	ENST00000328843.6	+	60	9753	c.9722A>G	c.(9721-9723)aAa>aGa	p.K3241R	DNAH11_ENST00000409508.3_Missense_Mutation_p.K3234R			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3241	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAGTGCCCAAAGACCGAAGT	0.493000									Kartagener syndrome				15	94					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197169426	197169426	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:197169426G>A	ENST00000367405.4	-	1	246	c.178C>T	c.(178-180)Cag>Tag	p.Q60*	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	60					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AGCTTTCTCTGATCTGGAGAG	0.383000													7	57					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55349366	55349366	+	Silent	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:55349366G>A	ENST00000371269.3	-	2	410	c.312C>T	c.(310-312)gtC>gtT	p.V104V	DHCR24_ENST00000535035.1_Silent_p.V63V	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	104	FAD-binding PCMH-type.				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						TGTACTTCCCGACACGTAGTG	0.537000													4	147					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202863749	202863749	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr1:202863749C>T	ENST00000367261.3	-	9	1482	c.1264G>A	c.(1264-1266)Gta>Ata	p.V422I	KLHL12_ENST00000367259.1_Missense_Mutation_p.V155I|KLHL12_ENST00000435533.3_Missense_Mutation_p.V460I	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	422	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			CTGGCCACTACGAGTCCGGCA	0.532000													4	151					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47938584	47938584	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr4:47938584G>A	ENST00000402813.3	-	10	2276	c.2134C>T	c.(2134-2136)Cga>Tga	p.R712*	CNGA1_ENST00000420489.2_Nonsense_Mutation_p.R643*|CNGA1_ENST00000358519.4_Nonsense_Mutation_p.R643*|CNGA1_ENST00000514170.1_Nonsense_Mutation_p.R643*|CNGA1_ENST00000544810.1_Nonsense_Mutation_p.R643*			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	643					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity	p.R643*(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						GCCAAGATTCGGGCAAACCTG	0.428000													6	126					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19055731	19055731	+	Silent	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr22:19055731G>A	ENST00000545799.1	-	3	410	c.210C>T	c.(208-210)acC>acT	p.T70T	DGCR2_ENST00000537045.1_Silent_p.T29T|DGCR2_ENST00000263196.7_Silent_p.T70T			P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	70					cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					GCACCTCCCCGGTCACTTCTG	0.637000													4	8					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77412339	77412339	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr11:77412339T>G	ENST00000308488.6	-	6	2237	c.1935A>C	c.(1933-1935)aaA>aaC	p.K645N	RSF1_ENST00000360355.2_Missense_Mutation_p.K614N|RSF1_ENST00000480887.1_Missense_Mutation_p.K393N			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	645					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTACCACTTCTTTTTCTGAGG	0.438000													18	179					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65314313	65314313	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr11:65314313G>T	ENST00000301873.5	-	15	2454	c.2186C>A	c.(2185-2187)gCc>gAc	p.A729D	LTBP3_ENST00000322147.4_Missense_Mutation_p.A729D|LTBP3_ENST00000532932.1_Missense_Mutation_p.A159D|LTBP3_ENST00000536982.1_Missense_Mutation_p.A355D	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	729	Cys-rich.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						AGGCTGACAGGCGATGCACTT	0.692000													15	44					6.31663e-08	7.14053e-08	1	1	0
LZTS1	11178	broad.mit.edu	37	8	20110914	20110914	+	Silent	SNP	C	C	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr8:20110914C>T	ENST00000381569.1	-	3	885	c.528G>A	c.(526-528)cgG>cgA	p.R176R	LZTS1_ENST00000522290.1_Silent_p.R176R|LZTS1_ENST00000265801.6_Silent_p.R176R			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	176					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		ACATGGAGTTCCGGCCGGAGT	0.672000													4	24					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105801073	105801073	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr10:105801073G>A	ENST00000353479.5	-	38	2925	c.2635C>T	c.(2635-2637)Cga>Tga	p.R879*	COL17A1_ENST00000369733.3_Nonsense_Mutation_p.R879*	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	879	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGTGGGCCTCGGGGTCCTGGT	0.647000													15	34					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992626	67992626	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr18:67992626G>T	ENST00000397942.3	+	2	1038	c.722G>T	c.(721-723)tGt>tTt	p.C241F	SOCS6_ENST00000582322.1_Missense_Mutation_p.C241F	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	241					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CGGAGCTATTGTCTGGACAGC	0.517000													3	33					0.115264	0.119875	1	1	0
ELMO1	9844	broad.mit.edu	37	7	36910037	36910037	+	Silent	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:36910037G>A	ENST00000310758.4	-	20	2513	c.1866C>T	c.(1864-1866)tgC>tgT	p.C622C	ELMO1_ENST00000442504.1_Silent_p.C622C|ELMO1_ENST00000341056.3_Silent_p.C324C|ELMO1_ENST00000396040.2_Silent_p.C142C|ELMO1_ENST00000396045.3_Silent_p.C142C|ELMO1_ENST00000448602.1_Silent_p.C622C	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	622	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TCATATGAGGGCAGTCCTTTC	0.433000													6	76					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50278227	50278227	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr22:50278227G>A	ENST00000216268.4	+	2	1394	c.917G>A	c.(916-918)tGc>tAc	p.C306Y		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	306						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AAAGCTGTCTGCATTCACTGC	0.582000													4	84					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27950458	27950458	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr9:27950458C>A	ENST00000379992.2	-	6	661	c.212G>T	c.(211-213)aGc>aTc	p.S71I	LINGO2_ENST00000308675.3_Missense_Mutation_p.S71I	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	71						integral to membrane		p.S71N(2)		autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AGGGTTGACGCTTTTTAGCCT	0.438000													18	171					3.99206e-14	4.61304e-14	1	1	0
MUC17	140453	broad.mit.edu	37	7	100678485	100678485	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:100678485C>T	ENST00000306151.4	+	3	3852	c.3788C>T	c.(3787-3789)gCt>gTt	p.A1263V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1263	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTACAACCGCTGAAGGTACC	0.522000													84	293					0	0	1	0	0
CRYGN	155051	broad.mit.edu	37	7	151127216	151127216	+	Missense_Mutation	SNP	G	G	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:151127216G>C	ENST00000337323.2	-	4	593	c.467C>G	c.(466-468)tCt>tGt	p.S156C	RP4-555L14.4_ENST00000465549.1_RNA|CRYGN_ENST00000476631.1_5'UTR	NM_144727.1	NP_653328.1	Q8WXF5	CRGN_HUMAN	crystallin, gamma N	156										central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(1)|lung(4)	8			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGATTGAAGAGAGCTGCTCAG	0.552000													7	44					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334946	50334946	+	Silent	SNP	A	A	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr3:50334946A>C	ENST00000354862.4	-	2	216	c.15T>G	c.(13-15)acT>acG	p.T5T	NAT6_ENST00000417393.1_5'UTR|HYAL3_ENST00000513170.1_Intron|NAT6_ENST00000443842.1_5'UTR|HYAL3_ENST00000450982.1_Intron|HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron|NAT6_ENST00000443094.2_5'UTR	NM_012191.3	NP_036323.2			N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CAGGGCTCAGAGTCAGCTCTT	0.602000													4	18					0	0	1	0	0
RFX2	5990	broad.mit.edu	37	19	6004297	6004297	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr19:6004297T>C	ENST00000303657.5	-	13	1564	c.1415A>G	c.(1414-1416)cAg>cGg	p.Q472R	RFX2_ENST00000359161.3_Missense_Mutation_p.Q472R|RFX2_ENST00000592546.1_Missense_Mutation_p.Q447R|CTC-232P5.1_ENST00000587836.1_RNA	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						ACGGATGGCCTGTGTCAAGGT	0.532000													3	50					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21607304	21607304	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr19:21607304A>G	ENST00000392288.2	+	4	1952	c.1843A>G	c.(1843-1845)Atc>Gtc	p.I615V	ZNF493_ENST00000355504.4_Missense_Mutation_p.I487V|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						CCGATCTTCAATCCTTAGTAT	0.373000													4	56					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128927061	128927061	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chrX:128927061C>A	ENST00000356892.3	+	7	1012	c.898C>A	c.(898-900)Cca>Aca	p.P300T		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	300	SAM.									breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						CATCATGGATCCACAGCACCG	0.587000													3	32					1	1	1	1	0
TTN	7273	broad.mit.edu	37	2	179449074	179449074	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr2:179449074T>C	ENST00000589042.1	-	311	65428	c.65204A>G	c.(65203-65205)tAt>tGt	p.Y21735C	TTN_ENST00000460472.2_Missense_Mutation_p.Y12670C|TTN_ENST00000342992.6_Missense_Mutation_p.Y19167C|TTN_ENST00000359218.5_Missense_Mutation_p.Y12795C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.Y20094C|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Y12862C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20094	Ig-like 114.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTAGGGCATAGATTCTGAA	0.428000													6	97					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21468304	21468306	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:21468304_21468306delAGG	ENST00000222584.3	+	2	235_237	c.17_19delAGG	c.(16-21)aag>a	p.KE6del		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	6					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GATCAGAAGAAGGAGGAGGAGGA	0.517													2	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100385562	100385596	+	RNA	DEL	GCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	GCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	-	rs68029369	by1000genomes	TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr7:100385562_100385596delGCTTCAGCTACCGCTTGCAAGGCCGCATGACCTAT	ENST00000542585.1	+	0	7176_7210				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACATTTGACGGCTTCAGCTACCGCTTGCAAGGCCGCATGACCTATGTTCTGATCA	0.583													8	29	---	---	---	---					
CTD-2008A1.2	0	broad.mit.edu	37	15	45123755	45123756	+	RNA	INS	-	-	C	rs11429544		TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chr15:45123755_45123756insC	ENST00000561384.2	-	0	871_872																											GGAGGCCTCTGCCCCGTGCACT	0.574													2	4	---	---	---	---					
PDK3	5165	broad.mit.edu	37	X	24545741	24545741	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EJ-7218-01B-11D-A32B-08	TCGA-EJ-7218-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	45c03982-3401-4737-b89c-b3a16aa6a7f4	1d53564b-d57c-4616-8950-9277fe4e08e5	g.chrX:24545741delC	ENST00000441463.2	+	8	801	c.801delC	c.(799-801)tafs	p.Y267fs	PDK3_ENST00000379162.4_Frame_Shift_Del_p.Y267fs	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	267	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AAGAGGGCTACCCTGCTGTTA	0.338													2	4	---	---	---	---					
