Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DTNB	1838	broad.mit.edu	37	2	25851073	25851073	+	Missense_Mutation	SNP	A	A	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:25851073A>C	ENST00000406818.3	-	4	578	c.329T>G	c.(328-330)cTc>cGc	p.L110R	DTNB_ENST00000545439.1_5'UTR|DTNB_ENST00000496972.2_Missense_Mutation_p.L53R|DTNB_ENST00000472690.1_5'UTR|DTNB_ENST00000288642.8_Missense_Mutation_p.L110R|DTNB_ENST00000407661.3_Missense_Mutation_p.L110R|DTNB_ENST00000407038.3_Missense_Mutation_p.L110R|DTNB_ENST00000407186.1_Missense_Mutation_p.L110R|DTNB_ENST00000405222.1_Missense_Mutation_p.L110R|DTNB_ENST00000404103.3_Missense_Mutation_p.L110R	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	110						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTGAGGAGGAGGCTGATAGA	0.428000													7	26					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121028755	121028755	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:121028755G>A	ENST00000392793.1	+	14	4782	c.4511G>A	c.(4510-4512)cGc>cAc	p.R1504H	TECTA_ENST00000264037.2_Missense_Mutation_p.R1504H			O75443	TECTA_HUMAN	tectorin alpha	1504	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCTTCCTGCGCTTCCCAGCC	0.657000													11	20					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40430352	40430352	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr19:40430352C>T	ENST00000221347.6	-	3	1598	c.1591G>A	c.(1591-1593)Gtc>Atc	p.V531I		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	531	VWFD 1.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGCACAGTGACGAGGCCCACG	0.652000													16	18					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128186	152128186	+	Silent	SNP	A	A	G			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:152128186A>G	ENST00000316073.3	-	3	1453	c.1389T>C	c.(1387-1389)taT>taC	p.Y463Y		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	463	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTCTGACCATAGTGGGAAC	0.512000													6	803					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37836309	37836309	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr4:37836309G>A	ENST00000381967.4	+	3	419	c.319G>A	c.(319-321)Gcc>Acc	p.A107T	PGM2_ENST00000537241.1_Intron|PGM2_ENST00000544359.1_5'UTR	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	107					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						CAGTTTTGACGCCCGAGCTCA	0.343000													3	51					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151164521	151164521	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr3:151164521C>T	ENST00000282466.3	-	4	3247	c.3248G>A	c.(3247-3249)aGt>aAt	p.S1083N		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1083					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGAGCAGCACTTGGAAAAGA	0.488000													33	79					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074846	106074846	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr10:106074846C>T	ENST00000278071.2	-	3	1416	c.964G>A	c.(964-966)Gac>Aac	p.D322N	ITPRIP_ENST00000337478.1_Missense_Mutation_p.D322N|ITPRIP_ENST00000358187.2_Missense_Mutation_p.D322N	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	322						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						AAGGCCAGGTCGAACTCGTAC	0.572000													25	61					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293269	145293269	+	Splice_Site	SNP	G	G	A	rs61350760	by1000genomes	TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:145293269G>A	ENST00000369338.1	+	1	155		c.e1+1		NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_Splice_Site			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10											NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTCACAACAGTAAGTTAAGA	0.423000													5	62					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237552	56237552	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:56237552C>T	ENST00000312240.2	-	1	462	c.422G>A	c.(421-423)cGa>cAa	p.R141Q		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AGTAATCAGTCGAATACAGAC	0.398000													43	93					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233898824	233898824	+	Splice_Site	SNP	A	A	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:233898824A>C	ENST00000233840.3	+	2	201		c.e2-1			NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)								exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CTCCCTACTCAGTGGCAAGCT	0.637000													23	56					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50212049	50212049	+	Missense_Mutation	SNP	C	C	A	rs141796718	by1000genomes	TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr19:50212049C>A	ENST00000392518.4	+	14	1891	c.1519C>A	c.(1519-1521)Ccc>Acc	p.P507T	CPT1C_ENST00000323446.5_Missense_Mutation_p.P507T|CPT1C_ENST00000405931.2_Missense_Mutation_p.P496T|CPT1C_ENST00000598293.1_Missense_Mutation_p.P507T|CPT1C_ENST00000354199.5_Missense_Mutation_p.P507T	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	507					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCACCCGGACCCCACACTACC	0.592000													23	71					5.35356e-11	5.74291e-11	1	1	0
COL21A1	0	broad.mit.edu	37	6	55939043	55939043	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr6:55939043G>A	ENST00000244728.5	-	20	2349	c.1952C>T	c.(1951-1953)aCa>aTa	p.T651I	COL21A1_ENST00000370808.2_Missense_Mutation_p.T51I|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Missense_Mutation_p.T651I|COL21A1_ENST00000370819.1_Missense_Mutation_p.T648I	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	651	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGATCCCGGTGTTCCAGGCTG	0.323000													17	49					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209518	140209518	+	Silent	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr5:140209518G>A	ENST00000529310.1	+	1	1956	c.1842G>A	c.(1840-1842)ccG>ccA	p.P614P	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.P614P(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGCCCCCGGCAAGCAGCG	0.672000													26	74					0	0	1	0	0
EPS15	2060	broad.mit.edu	37	1	51868169	51868169	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:51868169G>A	ENST00000371733.3	-	18	1916	c.1820C>T	c.(1819-1821)tCg>tTg	p.S607L	EPS15_ENST00000396122.4_Missense_Mutation_p.S284L|EPS15_ENST00000371730.2_Missense_Mutation_p.S473L	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	607	15 X 3 AA repeats of D-P-F.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						ACCTGTCAGCGAACTTGAGTC	0.264000			T	MLL	ALL								8	95					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748153	143748153	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr7:143748153G>A	ENST00000408906.2	+	1	693	c.659G>A	c.(658-660)cGc>cAc	p.R220H		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TCCTACTCGCGCATCCTGGCG	0.607000													4	187					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185834881	185834881	+	Silent	SNP	T	T	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:185834881T>C	ENST00000271588.4	+	4	736	c.507T>C	c.(505-507)ttT>ttC	p.F169F	HMCN1_ENST00000367492.2_Silent_p.F169F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	169	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AGGTCGTATTTGTTCTGACTG	0.338000													28	39					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158272280	158272280	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:158272280C>T	ENST00000264192.3	-	8	1110	c.989G>A	c.(988-990)cGg>cAg	p.R330Q	CYTIP_ENST00000540637.1_Missense_Mutation_p.R224Q	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	330					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TCTGCTCTTCCGGGGCAGGGT	0.512000													25	44					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137237147	137237147	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr7:137237147G>T	ENST00000453654.1	-	20	1754	c.1215C>A	c.(1213-1215)agC>agA	p.S405R	DGKI_ENST00000288490.5_Missense_Mutation_p.S705R|DGKI_ENST00000446122.1_Missense_Mutation_p.S705R|DGKI_ENST00000424189.2_Missense_Mutation_p.S705R			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	705	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						TTCTCCTCTTGCTCTTCTGTA	0.512000													6	81					0.00116845	0.00120944	1	1	0
DDI1	414301	broad.mit.edu	37	11	103908337	103908337	+	Missense_Mutation	SNP	G	G	A	rs114046986	by1000genomes	TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:103908337G>A	ENST00000302259.3	+	1	1030	c.787G>A	c.(787-789)Gcc>Acc	p.A263T	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	263					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGACTCGGGCGCCCAGATGAC	0.537000													50	69					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123333379	123333379	+	Silent	SNP	C	C	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr12:123333379C>A	ENST00000253083.4	+	4	462	c.337C>A	c.(337-339)Cgg>Agg	p.R113R		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	113	ENTH.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CAGCAACATCCGGGAGATTGG	0.642000													3	57					0.150653	0.153251	1	1	0
TPR	7175	broad.mit.edu	37	1	186307346	186307346	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:186307346T>C	ENST00000367478.3	-	31	4477	c.4181A>G	c.(4180-4182)aAc>aGc	p.N1394S		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1394					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CTGAATTAAGTTCTGGTTGTT	0.299000			T	NTRK1	papillary thyroid								17	27					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216011338	216011338	+	Silent	SNP	A	A	G			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:216011338A>G	ENST00000366943.2	-	47	9752	c.9366T>C	c.(9364-9366)acT>acC	p.T3122T	USH2A_ENST00000307340.3_Silent_p.T3122T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3122	Fibronectin type-III 18.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTACCTTGAAGTGATGCCAC	0.383000										HNSCC(13;0.011)			4	88					0	0	1	0	0
PCDHB10	0	broad.mit.edu	37	5	140574091	140574091	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr5:140574091G>A	ENST00000239446.4	+	1	2150	c.1966G>A	c.(1966-1968)Gcc>Acc	p.A656T		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		656	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGCCACCGCCACGCTGCA	0.711000													18	69					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67003937	67003937	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr17:67003937C>T	ENST00000340001.4	-	25	3609	c.3398G>A	c.(3397-3399)aGa>aAa	p.R1133K	ABCA9-AS1_ENST00000458677.1_RNA|ABCA9_ENST00000453985.2_Intron|ABCA9_ENST00000370732.2_Missense_Mutation_p.R1133K	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1133					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					ACTATTTTTTCTCCCATTGCG	0.313000													31	58					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24975732	24975732	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr14:24975732T>G	ENST00000250378.3	-	3	317	c.288A>C	c.(286-288)caA>caC	p.Q96H	RP11-80A15.1_ENST00000555109.1_Intron|CMA1_ENST00000206446.4_5'UTR	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	96	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		GATGACGGAATTGCTTTATAA	0.428000													38	101					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74272813	74272813	+	Missense_Mutation	SNP	G	G	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr17:74272813G>C	ENST00000262765.5	-	17	4982	c.4803C>G	c.(4801-4803)caC>caG	p.H1601Q		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1601							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CCTTGTAAATGTGGCCATCCA	0.597000													40	67					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17446197	17446197	+	Splice_Site	SNP	G	G	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr20:17446197G>T	ENST00000262545.2	+	11	1744	c.1430_splice	c.e11+1	p.E477_splice	PCSK2_ENST00000536609.1_Splice_Site_p.E442_splice|PCSK2_ENST00000377899.1_Splice_Site_p.E458_splice|PCSK2_ENST00000459871.1_3'UTR	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	477					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCAGGACCCTGAGTAAGTGGG	0.537000													11	11					0.000151284	0.000159389	1	1	0
IRF7	3665	broad.mit.edu	37	11	614247	614247	+	Silent	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:614247C>T	ENST00000397566.1	-	4	1054	c.645G>A	c.(643-645)ggG>ggA	p.G215G	IRF7_ENST00000348655.6_Silent_p.G202G|IRF7_ENST00000330243.5_Silent_p.G215G|IRF7_ENST00000397570.1_Silent_p.G202G|IRF7_ENST00000397562.3_Intron|IRF7_ENST00000397574.2_Silent_p.G202G|IRF7_ENST00000525445.1_Silent_p.G96G	NM_004031.2	NP_004022.2	Q92985	IRF7_HUMAN	interferon regulatory factor 7	202					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGGATCTGCCCCCCATGACG	0.677000													3	13					0	0	1	0	0
DSCC1	79075	broad.mit.edu	37	8	120859294	120859294	+	Silent	SNP	T	T	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr8:120859294T>C	ENST00000313655.4	-	4	727	c.513A>G	c.(511-513)caA>caG	p.Q171Q		NM_024094.2	NP_076999.2	Q9BVC3	DCC1_HUMAN	DNA replication and sister chromatid cohesion 1	171					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|pancreas(1)	9	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTGCCTGAATTTGATCAAGCA	0.303000													11	37					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1821092	1821092	+	Silent	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr4:1821092C>T	ENST00000302787.2	-	11	2012	c.1716G>A	c.(1714-1716)ctG>ctA	p.L572L		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	572					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CATCCTCCTTCAGCAGCTCCA	0.527000													27	24					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179702125	179702125	+	Missense_Mutation	SNP	T	T	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:179702125T>A	ENST00000420890.2	-	23	3938	c.3821A>T	c.(3820-3822)gAt>gTt	p.D1274V	CCDC141_ENST00000480419.1_5'UTR|CCDC141_ENST00000295723.5_Missense_Mutation_p.D699V	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	699							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATTGCATGCATCCGCAAAGGC	0.522000													23	38					0	0	1	0	0
NME9	347736	broad.mit.edu	37	3	138036991	138036991	+	Splice_Site	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr3:138036991G>A	ENST00000383180.2	-	6	437	c.201_splice	c.e6+1	p.A67_splice	NME9_ENST00000536478.1_Splice_Site_p.A67_splice|NME9_ENST00000484930.1_Intron|NME9_ENST00000333911.3_Splice_Site_p.A89_splice|NME9_ENST00000341790.5_Intron|NME9_ENST00000317876.4_Splice_Site_p.A67_splice	NM_178130.2	NP_835231.1	Q86XW9	TXND6_HUMAN	NME/NM23 family member 9	89	Thioredoxin.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TGTACTTACTGCATAAAACAG	0.398000													3	40					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088188	43088188	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr10:43088188G>T	ENST00000359467.3	-	5	2324	c.2210C>A	c.(2209-2211)gCt>gAt	p.A737D	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	737						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						CTGATGTTTAGCAAGGTCTGA	0.393000													41	99					9.73076e-26	1.06318e-25	1	1	0
HPN	3249	broad.mit.edu	37	19	35540280	35540280	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr19:35540280G>A	ENST00000262626.2	+	3	928	c.103G>A	c.(103-105)Gca>Aca	p.A35T	HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Missense_Mutation_p.A35T	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	35					cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	CATCGGGGCGGCATCCTGGGC	0.662000													4	109					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178634658	178634658	+	Silent	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr5:178634658G>A	ENST00000251582.7	-	4	848	c.747C>T	c.(745-747)caC>caT	p.H249H	ADAMTS2_ENST00000274609.5_Silent_p.H249H	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	249					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGCTGTTGGCGTGCTCCTCTA	0.657000													6	96					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													7	56					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810901	65810901	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:65810901C>T	ENST00000312006.4	-	3	654	c.373G>A	c.(373-375)Gtg>Atg	p.V125M	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.V125M	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	125					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						CTGGCCAGCACGTGCGGCGGC	0.711000													8	13					0	0	1	0	0
C2orf44	80304	broad.mit.edu	37	2	24262247	24262247	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:24262247G>A	ENST00000295148.4	-	2	175	c.118C>T	c.(118-120)Cgg>Tgg	p.R40W	C2orf44_ENST00000406895.3_Missense_Mutation_p.R40W	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	40							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGTGAAGCCGCAAATCAGTT	0.507000			T	ALK	NSCLC								3	59					0	0	1	0	0
PDE6D	5147	broad.mit.edu	37	2	232602765	232602765	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr2:232602765G>A	ENST00000287600.4	-	3	417	c.223C>T	c.(223-225)Cgc>Tgc	p.R75C	PDE6D_ENST00000409772.1_Missense_Mutation_p.R75C	NM_002601.2	NP_002592.1	O43924	PDE6D_HUMAN	phosphodiesterase 6D, cGMP-specific, rod, delta	75					regulation of GTP catabolic process|response to stimulus|visual perception		3',5'-cyclic-nucleotide phosphodiesterase activity|GTPase inhibitor activity|protein binding	p.R75C(1)		endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.142)		Epithelial(121;2.19e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00145)|LUSC - Lung squamous cell carcinoma(224;0.0125)|Lung(119;0.0154)		TGTTCCAGGCGGAATTTTTCC	0.443000													22	36					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14108213	14108213	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:14108213G>A	ENST00000235372.7	+	8	4779	c.3923G>A	c.(3922-3924)cGt>cAt	p.R1308H	PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.R1107H|PRDM2_ENST00000311066.5_Missense_Mutation_p.R1308H|PRDM2_ENST00000343137.4_Missense_Mutation_p.R1107H|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	1308						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TACCATCACCGTAACCCCATG	0.443000													4	164					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159128	18159128	+	Missense_Mutation	SNP	C	C	G			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:18159128C>G	ENST00000396275.2	+	3	740	c.379C>G	c.(379-381)Ccc>Gcc	p.P127A		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	127						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CATCCTGTGGCCCATCTGGTA	0.572000													6	138					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104118778	104118778	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr12:104118778C>T	ENST00000388887.2	+	45	4913	c.4709C>T	c.(4708-4710)gCc>gTc	p.A1570V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1570	EGF-like 14.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGTGAATTTGCCATCTGCAAC	0.468000													4	234					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40359850	40359850	+	Silent	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr6:40359850C>T	ENST00000338305.6	-	3	2744	c.2202G>A	c.(2200-2202)gcG>gcA	p.A734A		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	734						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					CGACCCCTCCCGCCGCCGCAG	0.672000													9	17					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7759621	7759621	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr10:7759621C>T	ENST00000358415.4	+	6	666	c.500C>T	c.(499-501)aCg>aTg	p.T167M	ITIH2_ENST00000480387.1_3'UTR|ITIH2_ENST00000379587.4_Missense_Mutation_p.T156M	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	167	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AACTTCAGAACGGAAGTAAAT	0.488000													9	206					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11917051	11917051	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr19:11917051A>G	ENST00000323169.5	+	3	614	c.283A>G	c.(283-285)Agg>Ggg	p.R95G	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						AACACATGAAAGGCCTCACAC	0.393000													31	45					0	0	1	0	0
SLC31A1	1317	broad.mit.edu	37	9	116018436	116018436	+	Missense_Mutation	SNP	A	A	T			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr9:116018436A>T	ENST00000374212.4	+	2	160	c.8A>T	c.(7-9)cAt>cTt	p.H3L	CDC26_ENST00000490408.1_Intron|SLC31A1_ENST00000374210.6_Missense_Mutation_p.H3L	NM_001859.3	NP_001850.1	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporter), member 1	3						integral to plasma membrane	copper ion transmembrane transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7						AAAATGGATCATTCCCACCAT	0.383000													21	54					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444143	5444143	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr11:5444143G>A	ENST00000300778.4	+	1	803	c.713G>A	c.(712-714)cGt>cAt	p.R238H	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R238H(1)		endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCGACTCCGTGCCCTCAAT	0.488000													25	63					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19756730	19756730	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr19:19756730T>C	ENST00000357324.6	-	24	3339	c.3313A>G	c.(3313-3315)Atc>Gtc	p.I1105V	ATP13A1_ENST00000291503.5_Missense_Mutation_p.I987V	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	1105					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						ATGGCCATGATGTAGACGGTG	0.582000													66	128					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661187	22661187	+	RNA	SNP	G	G	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr22:22661187G>A	ENST00000426066.1	+	0	279					NR_027293.1																						CCCCCACCCCGTCATGTACAG	0.413000													3	30					0	0	1	0	0
RP11-782C8.1	0	broad.mit.edu	37	1	143217265	143217266	+	RNA	INS	-	-	A			TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr1:143217265_143217266insA	ENST00000438000.1	+	0	59																											GTTAGTAAAGCAAAAAAAAAAC	0.282													2	4	---	---	---	---					
LINC00475	0	broad.mit.edu	37	9	94904432	94904432	+	RNA	DEL	G	G	-	rs58003635		TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr9:94904432delG	ENST00000416438.2	+	0	184					NR_027341.1																						GGCCTTCTTTGGGGGGGGGGT	0.612													2	4	---	---	---	---					
ALDH1A3	220	broad.mit.edu	37	15	101438349	101438350	+	Frame_Shift_Ins	INS	-	-	G	rs142377552	byFrequency	TCGA-EJ-A7NN-01A-11D-A33T-08	TCGA-EJ-A7NN-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860c80f6-64b2-4089-87ee-8d64a6eba17b	c9b96788-9d99-4be5-a458-9e3d2c8755ea	g.chr15:101438349_101438350insG	ENST00000329841.5	+	8	1374_1375	c.842_843insG	c.(841-843)cggfs	p.R281fs	ALDH1A3_ENST00000346623.6_Frame_Shift_Ins_p.R174fs|RP11-66B24.4_ENST00000560351.1_RNA	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	281					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACGCTGGAGCTGGGGGGGAAGA	0.569													12	48	---	---	---	---					
