Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SERPINB5	5268	broad.mit.edu	37	18	61160285	61160285	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr18:61160285T>C	ENST00000382771.4	+	5	816	c.524T>C	c.(523-525)tTt>tCt	p.F175S	SERPINB5_ENST00000464346.1_3'UTR|SERPINB5_ENST00000489441.1_Missense_Mutation_p.F175S	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	175					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						ATGAAGAAATTTTCTGAATCA	0.403000													29	99					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871061	170871061	+	Silent	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr6:170871061G>A	ENST00000392092.2	+	3	516	c.237G>A	c.(235-237)caG>caA	p.Q79Q	TBP_ENST00000540980.1_Silent_p.Q59Q|TBP_ENST00000230354.6_Silent_p.Q79Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	79	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q79Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.582000													4	57					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63453881	63453881	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr14:63453881G>T	ENST00000322893.7	-	5	726	c.458C>A	c.(457-459)aCa>aAa	p.T153K	KCNH5_ENST00000420622.2_Missense_Mutation_p.T153K|KCNH5_ENST00000394964.2_Missense_Mutation_p.T95K|KCNH5_ENST00000394968.1_Missense_Mutation_p.T95K	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	153					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CAAAGCCCGTGTCAATCGGGC	0.378000													10	60					0.0692343	0.0692343	1	1	0
OR4S2	219431	broad.mit.edu	37	11	55419263	55419263	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:55419263C>A	ENST00000312422.2	+	1	884	c.884C>A	c.(883-885)gCa>gAa	p.A295E		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GTAAAGAATGCAATGAAGAAA	0.363000													13	217					0.000151284	0.000159043	1	1	0
TSPY2	64591	broad.mit.edu	37	Y	6114373	6114373	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chrY:6114373G>A	ENST00000320701.4	+	1	110	c.64G>A	c.(64-66)Gtg>Atg	p.V22M	TSPY2_ENST00000383042.1_Missense_Mutation_p.V22M	NM_022573.2	NP_072095.2	A6NKD2	TSPY2_HUMAN	testis specific protein, Y-linked 2	22					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus		p.V22L(1)		liver(1)|lung(4)|prostate(1)|skin(1)	7						TTCCTGTGGCGTGGGTCGGGC	0.711000													11	20					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681387	142681387	+	Silent	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr3:142681387G>A	ENST00000340634.3	-	1	791	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	264						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						CACGCAGGTCGAAGAGCCAGC	0.622000													4	84					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132169640	132169640	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr7:132169640T>C	ENST00000378539.5	-	5	1880	c.1504A>G	c.(1504-1506)Ata>Gta	p.I502V	PLXNA4_ENST00000359827.3_Intron|PLXNA4_ENST00000321063.4_Intron|PLXNA4_ENST00000423507.2_Intron	NM_181775.3	NP_861440.2	Q9HCM2	PLXA4_HUMAN	plexin A4	0	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TGATCTGATATTGCTTTGTGA	0.448000													16	74					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6387480	6387480	+	Silent	SNP	G	G	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:6387480G>C	ENST00000394456.5	-	5	881	c.417C>G	c.(415-417)ccC>ccG	p.P139P	CTB-180A7.6_ENST00000599584.1_RNA|GTF2F1_ENST00000429701.2_Intron	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	139					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						AGTTGTGCACGGGGAAGGCCT	0.627000													11	80					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978841	58978841	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:58978841C>T	ENST00000361050.3	-	1	1583	c.1498G>A	c.(1498-1500)Ggc>Agc	p.G500S		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	500						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GGAAAGTAGCCGGCTGGGCAT	0.512000													9	89					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480545	10480545	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr8:10480545C>T	ENST00000382483.3	-	2	390	c.167G>A	c.(166-168)cGc>cAc	p.R56H	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	56					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTTAAAGGCGCGCTGGTGAAC	0.652000													10	68					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47278910	47278910	+	Silent	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr2:47278910C>T	ENST00000319190.5	+	18	2411	c.2043C>T	c.(2041-2043)gcC>gcT	p.A681A	TTC7A_ENST00000263737.6_Silent_p.A327A|TTC7A_ENST00000409245.1_Silent_p.A647A|TTC7A_ENST00000394850.2_Silent_p.A705A	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	681							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CGTCCATCGCCGCCTCCCGGC	0.657000													16	57					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145629382	145629382	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr4:145629382C>A	ENST00000296575.3	+	7	1875	c.1220C>A	c.(1219-1221)tCc>tAc	p.S407Y		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	407						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GTGCCTTATTCCATACCAAGG	0.507000													8	59					5.4927e-09	6.08651e-09	1	1	0
DIO1	1733	broad.mit.edu	37	1	54360027	54360027	+	Splice_Site	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr1:54360027G>A	ENST00000525202.1	+	1	144	c.145_splice	c.e1+1	p.T48_splice	DIO1_ENST00000388876.3_Silent_p.T48T|DIO1_ENST00000322679.6_Silent_p.T48T|DIO1_ENST00000532493.1_Silent_p.T48T|DIO1_ENST00000534069.1_3'UTR|DIO1_ENST00000361921.3_Silent_p.T48T|DIO1_ENST00000524406.1_Intron			P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I	48					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(2)|skin(1)	9						GCGAGAAGACGGGTATGACCA	0.527000													14	64					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249309	61249309	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:61249309G>A	ENST00000338608.2	+	2	153	c.28G>A	c.(28-30)Gtc>Atc	p.V10I	RP11-286N22.8_ENST00000543044.1_3'UTR|PPP1R32_ENST00000432063.2_Missense_Mutation_p.V10I|RP11-286N22.8_ENST00000544880.1_Intron	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	10																	CCTGGGGGTCGTCTCCCCTTA	0.632000													3	29					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959779	38959779	+	Splice_Site	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:38959779C>T	ENST00000355481.4	+	26	3686	c.3556_splice	c.e26+1	p.D1185_splice	RYR1_ENST00000360985.3_Splice_Site_p.D1185_splice|RYR1_ENST00000359596.3_Splice_Site_p.D1185_splice	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1185	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGATTGGGGACGGTGAGGGCT	0.557000													5	57					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103623	53103623	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr7:53103623G>A	ENST00000408890.4	+	1	275	c.259G>A	c.(259-261)Gcc>Acc	p.A87T		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	87										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCAGGACCCCGCCAAGCCGCA	0.701000													11	26					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49485161	49485161	+	Silent	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:49485161C>T	ENST00000266991.2	-	2	621	c.315G>A	c.(313-315)gaG>gaA	p.E105E	RP11-386G11.8_ENST00000553174.1_RNA	NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	105					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						CGTTCACCCGCTCCTTACAAC	0.587000													4	26					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													3	33					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45317538	45317538	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr19:45317538G>A	ENST00000391955.1	+	7	958	c.914G>A	c.(913-915)cGc>cAc	p.R305H	BCAM_ENST00000270233.6_Missense_Mutation_p.R305H			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	305	Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				ACGCTTTTCCGCCTTCAGGTG	0.652000													7	87					0	0	1	0	0
CCDC112	153733	broad.mit.edu	37	5	114611297	114611297	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr5:114611297T>A	ENST00000379611.5	-	6	821	c.534A>T	c.(532-534)gaA>gaT	p.E178D	CCDC112_ENST00000512261.1_Missense_Mutation_p.E95D|CCDC112_ENST00000503027.1_5'UTR|CCDC112_ENST00000395557.4_Missense_Mutation_p.E95D|CCDC112_ENST00000506442.1_Missense_Mutation_p.E95D	NM_001040440.2	NP_001035530.1	Q8NEF3	CC112_HUMAN	coiled-coil domain containing 112	95										endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|skin(1)	20		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		TAATTAGCTCTTCATATCTAA	0.289000													5	40					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160047852	160047852	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr5:160047852T>C	ENST00000327245.5	-	15	2764	c.1918A>G	c.(1918-1920)Act>Gct	p.T640A	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	640					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGGGTGCAGTGGATGAGAAT	0.552000													10	154					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87225083	87225083	+	Splice_Site	SNP	A	A	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr7:87225083A>T	ENST00000265724.3	-	4	533	c.117_splice	c.e4+1	p.M39_splice	ABCB1_ENST00000543898.1_Splice_Site_p.M39_splice	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	39					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AAAACTCACCATTGAAAATAC	0.274000													4	32					0	0	1	0	0
LZTS2	84445	broad.mit.edu	37	10	102762582	102762582	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr10:102762582G>A	ENST00000370220.1	+	1	3350	c.287G>A	c.(286-288)cGg>cAg	p.R96Q	LZTS2_ENST00000370223.3_Missense_Mutation_p.R96Q			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	96	Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GAGGACTTCCGGACAGAGTCA	0.627000													13	47					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018760	62018760	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:62018760C>T	ENST00000578147.1	-	24	4958	c.4882G>A	c.(4882-4884)Gac>Aac	p.D1628N	SCN4A_ENST00000435607.1_Missense_Mutation_p.D1628N			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1628					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCGTCGGGGTCGAACTTCTCC	0.562000													10	61					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43205697	43205697	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr18:43205697T>A	ENST00000255226.6	+	3	1016	c.200T>A	c.(199-201)cTc>cAc	p.L67H	SLC14A2_ENST00000586448.1_Missense_Mutation_p.L67H	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	67						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATCGAAAAGCTCAATGAAAGG	0.502000													4	15					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38924806	38924806	+	Missense_Mutation	SNP	C	C	T	rs147061364	byFrequency	TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr3:38924806C>T	ENST00000450244.1	-	18	3335	c.3137G>A	c.(3136-3138)cGg>cAg	p.R1046Q	SCN11A_ENST00000456224.3_Missense_Mutation_p.R1008Q|SCN11A_ENST00000444237.2_Missense_Mutation_p.R1046Q|SCN11A_ENST00000302328.3_Missense_Mutation_p.R1046Q			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1046					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCAGGTTTTCCGCAGGTTCCA	0.453000													6	69					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40475084	40475084	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr17:40475084C>G	ENST00000264657.5	-	20	2138	c.1826G>C	c.(1825-1827)aGa>aCa	p.R609T	STAT3_ENST00000585517.1_Missense_Mutation_p.R609T|STAT3_ENST00000404395.3_Missense_Mutation_p.R609T|STAT3_ENST00000389272.3_Missense_Mutation_p.R511T|STAT3_ENST00000588969.1_Missense_Mutation_p.R609T	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	609	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TTCACTGAATCTTAGCAGGAA	0.562000									Hyperimmunoglobulin E Recurrent Infection Syndrome		OREG0024421	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	124					0	0	1	0	0
SP1	0	broad.mit.edu	37	12	53777378	53777378	+	Silent	SNP	C	C	G			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:53777378C>G	ENST00000426431.2	+	3	1686	c.1626C>G	c.(1624-1626)ggC>ggG	p.G542G	SP1_ENST00000327443.4_Silent_p.G549G	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	549	Transactivation domain C (highly charged).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CAATTCAAGGCCTGCCGTTGG	0.478000													16	81					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118949955	118949955	+	Silent	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:118949955C>A	ENST00000300793.6	+	15	2422	c.2380C>A	c.(2380-2382)Cgg>Agg	p.R794R	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	795					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GCGGGTGCGGCGGTACCGAGA	0.582000													3	13					0.00024832	0.000254528	1	1	0
HOXC8	3224	broad.mit.edu	37	12	54403269	54403269	+	Silent	SNP	C	C	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:54403269C>A	ENST00000040584.4	+	1	438	c.201C>A	c.(199-201)atC>atA	p.I67I		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	67						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						CCTCCGGCATCTCCAACTCAG	0.637000													15	260					2.23348e-06	2.40981e-06	1	1	0
PIWIL1	9271	broad.mit.edu	37	12	130830316	130830316	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr12:130830316G>A	ENST00000245255.3	+	4	481	c.209G>A	c.(208-210)gGa>gAa	p.G70E		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	70					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATATCTGCTGGATTTCAGGAG	0.378000													14	57					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938178	15938178	+	Frame_Shift_Del	DEL	T	T	-	rs144178676		TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr4:15938178delT	ENST00000382333.1	-	3	372	c.78delA	c.(76-78)aafs	p.K26fs	FGFBP1_ENST00000259988.2_Frame_Shift_Del_p.K26fs	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	26					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						CATTCTTCACTTTTTTTTTCC	0.527													7	107	---	---	---	---					
RP11-360K13.1	0	broad.mit.edu	37	11	96515048	96515048	+	RNA	DEL	T	T	-			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr11:96515048delT	ENST00000527528.1	+	0	158																											AGGCAGCTGGTTTTTTTTGAA	0.378													2	4	---	---	---	---					
CSNK1A1L	122011	broad.mit.edu	37	13	37678967	37678967	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr13:37678967delG	ENST00000379800.3	-	1	836	c.427delC	c.(427-429)tgfs	p.L143fs		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	143	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GTACCCATCAGGAAGTTATCT	0.408													9	120	---	---	---	---					
MIS18BP1	55320	broad.mit.edu	37	14	45711597	45711601	+	Frame_Shift_Del	DEL	AGTGG	AGTGG	-			TCGA-G9-6379-01A-11D-A31L-08	TCGA-G9-6379-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	184256e3-08e8-423a-bb1e-fbcf52d671d7	68f54bda-df0c-4b1e-a81e-9d90763711ac	g.chr14:45711597_45711601delAGTGG	ENST00000310806.4	-	4	1237_1241	c.779_783delCCACT	c.(778-783)afs	p.TT260fs		NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	260					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						TTTTGGATTTAGTGGTTGCAACTAT	0.356													11	89	---	---	---	---					
