Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD36BP2	0	broad.mit.edu	37	2	89086005	89086005	+	RNA	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:89086005C>T	ENST00000393525.3	+	0	830																											CAGAAACAATCGGCCTGGAAG	0.303000													3	6					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	190					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241725859	241725859	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:241725859G>A	ENST00000498729.2	-	6	747	c.501C>T	c.(499-501)cgC>cgT	p.R167R	KIF1A_ENST00000320389.7_Silent_p.R167R	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	167	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GCTCCCTCACGCGAAGGTTGC	0.602000													62	94					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													4	188					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													5	311					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55524135	55524135	+	Missense_Mutation	SNP	G	G	A	rs77545847	byFrequency	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:55524135G>A	ENST00000305377.5	+	1	671	c.583G>A	c.(583-585)Gct>Act	p.A195T		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						ATCTTTTTGCGCTTCTCGGGC	0.418000													24	70					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16593777	16593777	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:16593777C>T	ENST00000443444.2	+	1	203	c.63C>T	c.(61-63)taC>taT	p.Y21Y	CCDC144A_ENST00000436374.1_3'UTR|CCDC144A_ENST00000340621.5_Silent_p.Y21Y|RP11-219A15.1_ENST00000448331.3_Silent_p.Y21Y|CCDC144A_ENST00000360524.8_Silent_p.Y21Y|CCDC144A_ENST00000456009.1_Silent_p.Y21Y|CCDC144A_ENST00000399273.1_Silent_p.Y21Y			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	21																	CGGCAGTCTACGCCACGAGGA	0.667000													18	27					0	0	1	0	0
TRBC2	0	broad.mit.edu	37	7	142499092	142499092	+	RNA	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr7:142499092C>T	ENST00000466254.1	+	0	368																											TCGTCAGCGCCGAGGCCTGGG	0.597000													28	184					0	0	1	0	0
ZSCAN30	100101467	broad.mit.edu	37	18	32843993	32843993	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr18:32843993C>T	ENST00000420878.3	-	3	779	c.324G>A	c.(322-324)ctG>ctA	p.L108L	ZSCAN30_ENST00000333206.5_Silent_p.L108L|ZNF397_ENST00000589420.1_Intron|ZSCAN30_ENST00000601405.1_Intron|ZSCAN30_ENST00000592278.1_Silent_p.L108L|ZSCAN30_ENST00000383091.2_Silent_p.L108L|ZSCAN30_ENST00000589178.1_Silent_p.L108L	NM_001166012.1	NP_001159484.1	Q86W11	ZSC30_HUMAN	zinc finger and SCAN domain containing 30	108	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|lung(3)|urinary_tract(1)	9						GATGCTCTCGCAGCCAAGCTT	0.547000													5	96					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50344881	50344881	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:50344881G>A	ENST00000199280.3	+	1	353	c.268G>A	c.(268-270)Gtg>Atg	p.V90M		NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	90					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						CGCCTTCTACGTGGCTGCCCA	0.662000													13	37					0	0	1	0	0
PTPRA	0	broad.mit.edu	37	20	3017847	3017847	+	Missense_Mutation	SNP	T	T	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:3017847T>A	ENST00000216877.6	+	22	2619	c.2219T>A	c.(2218-2220)cTg>cAg	p.L740Q	PTPRA_ENST00000356147.3_Missense_Mutation_p.L740Q|PTPRA_ENST00000425918.2_Missense_Mutation_p.L760Q|PTPRA_ENST00000380393.3_Missense_Mutation_p.L749Q|PTPRA_ENST00000358719.4_Missense_Mutation_p.L605Q|PTPRA_ENST00000318266.5_Missense_Mutation_p.L740Q|PTPRA_ENST00000399903.2_Missense_Mutation_p.L749Q	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	749	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AGCACCGTCCTGGAGCGTGTG	0.592000													38	76					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57458438	57458438	+	Missense_Mutation	SNP	G	G	A	rs138462668	byFrequency	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrX:57458438G>A	ENST00000374900.4	+	8	1204	c.1084G>A	c.(1084-1086)Gca>Aca	p.A362T	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	362						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GTTGTGGATCGCAATGATGTC	0.348000										HNSCC(52;0.14)			31	4					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19041626	19041626	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:19041626G>A	ENST00000421369.3	+	6	1020	c.462G>A	c.(460-462)ctG>ctA	p.L154L	TMC7_ENST00000304381.5_Silent_p.L264L|TMC7_ENST00000569532.1_Silent_p.L264L	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	264						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CCTATGATCTGCCCCTGGCGT	0.468000													36	63					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3691150	3691150	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:3691150C>T	ENST00000250699.2	-	2	154	c.83G>A	c.(82-84)cGg>cAg	p.R28Q	CHRNA10_ENST00000534359.1_Intron	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	28					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GAGAGCCAGCCGGCCCTCAGC	0.612000													31	62					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76435207	76435207	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:76435207C>T	ENST00000389840.5	-	73	11852	c.11728G>A	c.(11728-11730)Gtg>Atg	p.V3910M	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.V3919M					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGCAGCCACGTCCAGGGCG	0.562000													4	37					0	0	1	0	0
RPA4	29935	broad.mit.edu	37	X	96140039	96140039	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chrX:96140039G>A	ENST00000373040.3	+	1	1133	c.730G>A	c.(730-732)Gtt>Att	p.V244I	DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000355827.4_Intron|DIAPH2_ENST00000324765.8_Intron|DIAPH2_ENST00000373061.3_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	244					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						TTATCTGACCGTTGAGGGCCA	0.507000								Other identified genes with known or suspected DNA repair function					3	39					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76117241	76117241	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr17:76117241G>A	ENST00000590602.1	-	12	1547	c.1388C>T	c.(1387-1389)cCa>cTa	p.P463L	TMC6_ENST00000306591.7_Intron|TMC6_ENST00000392467.3_Missense_Mutation_p.P463L|TMC6_ENST00000592076.1_Intron|TMC6_ENST00000589553.1_Missense_Mutation_p.P236L|TMC6_ENST00000591436.1_Missense_Mutation_p.P102L|TMC6_ENST00000322933.4_Missense_Mutation_p.P102L|TMC6_ENST00000322914.3_Missense_Mutation_p.P463L			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	463						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCAGCCTCTGGACTCTGCAG	0.697000													6	15					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117104291	117104291	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr9:117104291G>A	ENST00000307564.4	-	20	4033	c.3872C>T	c.(3871-3873)tCt>tTt	p.S1291F	AKNA_ENST00000374079.4_Missense_Mutation_p.S236F|AKNA_ENST00000223791.3_Missense_Mutation_p.S751F|AKNA_ENST00000374075.5_Missense_Mutation_p.S1210F|AKNA_ENST00000374088.3_Missense_Mutation_p.S1291F|AKNA_ENST00000492875.1_5'UTR	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GTCCCTACCAGAGGTGGCTGA	0.567000													33	71					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6554692	6554692	+	Missense_Mutation	SNP	A	A	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr12:6554692A>G	ENST00000266557.3	+	2	468	c.239A>G	c.(238-240)cAc>cGc	p.H80R	CD27_ENST00000541233.1_3'UTR|CD27-AS1_ENST00000399492.2_RNA|CD27-AS1_ENST00000545339.1_RNA	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	80					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						ACCCGGCCCCACTGTGAGAGC	0.587000													21	45					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73622050	73622050	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:73622050G>A	ENST00000261917.3	-	4	2447	c.1454C>T	c.(1453-1455)gCg>gTg	p.A485V		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	485					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GCCCACGGGCGCCTGCCGCCC	0.622000													39	62					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	45					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50900484	50900484	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr22:50900484C>T	ENST00000380817.2	-	20	2644	c.2461G>A	c.(2461-2463)Gac>Aac	p.D821N	SBF1_ENST00000390679.3_Missense_Mutation_p.D821N|SBF1_ENST00000348911.6_Missense_Mutation_p.D822N	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	821					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CCAGCTACGTCGCAGGTCTCT	0.617000													63	158					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796912	127796912	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr6:127796912G>A	ENST00000556132.1	-	6	3123	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	SOGA3_ENST00000481848.2_Silent_p.A753A|SOGA3_ENST00000525778.1_Silent_p.A753A|SOGA3_ENST00000465909.2_Silent_p.A753A|SOGA3_ENST00000368268.2_Silent_p.A753A	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	753						integral to membrane											CGTCGCTCTCGGCGTCGCTGT	0.697000													7	132					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52383437	52383437	+	Splice_Site	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr3:52383437G>A	ENST00000420323.2	+	14	2787		c.e14+1			NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1						ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGTGGATAGCGTAAGTGCCCA	0.582000													3	35					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54410070	54410070	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr5:54410070C>T	ENST00000296733.1	-	12	1698	c.1524G>A	c.(1522-1524)acG>acA	p.T508T	CDC20B_ENST00000322374.6_Silent_p.T470T|CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000381375.2_Silent_p.T512T	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	512										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			atacagaggccgtcccatcag	0.527000													26	57					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156786061	156786061	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr5:156786061G>A	ENST00000347377.6	+	24	3153	c.2722G>A	c.(2722-2724)Gtg>Atg	p.V908M	CYFIP2_ENST00000541131.1_Missense_Mutation_p.V833M|CYFIP2_ENST00000435847.2_Missense_Mutation_p.V607M|CYFIP2_ENST00000318218.6_Missense_Mutation_p.V933M|CYFIP2_ENST00000377576.3_Missense_Mutation_p.V908M|CYFIP2_ENST00000522463.1_Missense_Mutation_p.V712M|CYFIP2_ENST00000442283.2_Missense_Mutation_p.R192H|CYFIP2_ENST00000521420.1_Missense_Mutation_p.V882M	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	933					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGGAATTTCGTGGGGCCACC	0.488000													6	280					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238562	104238562	+	Missense_Mutation	SNP	C	C	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr9:104238562C>A	ENST00000374851.1	-	4	1960	c.813G>T	c.(811-813)ttG>ttT	p.L271F	TMEM246_ENST00000374848.3_Missense_Mutation_p.L271F|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.L271F			Q9BRR3	CI125_HUMAN	transmembrane protein 246	271						integral to membrane											AGGGCCCCAGCAACATGCCTA	0.537000													70	129					4.37588e-27	4.74054e-27	1	1	0
ABCG2	9429	broad.mit.edu	37	4	89013441	89013441	+	Missense_Mutation	SNP	A	A	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr4:89013441A>G	ENST00000237612.3	-	16	2458	c.1913T>C	c.(1912-1914)gTt>gCt	p.V638A	ABCG2_ENST00000515655.1_3'UTR	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	638	ABC transmembrane type-2.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGGAAAATAACAATCATACA	0.363000													22	45					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	60					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895797	24895797	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr13:24895797G>A	ENST00000382071.2	+	4	978	c.893G>A	c.(892-894)gGg>gAg	p.G298E	C1QTNF9_ENST00000332018.4_Missense_Mutation_p.G298E			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	298	C1q.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CTGAAGCTCGGGGATGAGGTG	0.507000													4	121					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95795914	95795914	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:95795914G>T	ENST00000414645.2	+	17	1831	c.1732G>T	c.(1732-1734)Gca>Tca	p.A578S		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	578						integral to membrane		p.A578T(1)		breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					AGCTCCAGTTGCAGCTGTGTT	0.403000													15	24					5.01169e-05	5.31853e-05	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10464989	10464989	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:10464989G>T	ENST00000382483.3	-	4	6842	c.6619C>A	c.(6619-6621)Cca>Aca	p.P2207T		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2207					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCTAACTCTGGTTGGGCCTCC	0.632000													26	429					0.000117367	0.000122062	1	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75929559	75929559	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr8:75929559C>T	ENST00000262207.4	+	10	1469	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	CRISPLD1_ENST00000523524.1_Missense_Mutation_p.S146F|CRISPLD1_ENST00000517786.1_Missense_Mutation_p.S148F	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	334	LCCL 1.					extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TCCAAGCAATCCAGCATCTGT	0.338000													5	84					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718522	103718522	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr13:103718522G>T	ENST00000245312.3	-	1	674	c.78C>A	c.(76-78)ttC>ttA	p.F26L		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	26					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGATGTTATTGAAATTGCTCT	0.478000													7	133					0.000157383	0.000160469	1	1	0
ZFYVE27	118813	broad.mit.edu	37	10	99502873	99502873	+	Missense_Mutation	SNP	T	T	G			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr10:99502873T>G	ENST00000393677.4	+	3	424	c.220T>G	c.(220-222)Ttg>Gtg	p.L74V	ZFYVE27_ENST00000357540.4_Intron|ZFYVE27_ENST00000356257.4_Missense_Mutation_p.L74V|ZFYVE27_ENST00000359980.3_Missense_Mutation_p.L74V|ZFYVE27_ENST00000453958.2_Missense_Mutation_p.L74V|ZFYVE27_ENST00000337540.7_Intron|ZFYVE27_ENST00000370610.3_Intron|ZFYVE27_ENST00000370613.3_Intron	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	74					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		TTTGTGTTCCTTGCTGACCTG	0.547000													41	87					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3797159	3797159	+	Missense_Mutation	SNP	G	G	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:3797159G>T	ENST00000324932.7	-	5	868	c.448C>A	c.(448-450)Cca>Aca	p.P150T	NUP98_ENST00000397004.4_Missense_Mutation_p.P150T|NUP98_ENST00000397007.4_Missense_Mutation_p.P150T|NUP98_ENST00000359171.4_Missense_Mutation_p.P150T|NUP98_ENST00000355260.3_Missense_Mutation_p.P150T	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	150	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AAACTACTTGGCCCAAAGAGG	0.398000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								4	131					1	1	1	1	0
ACAN	176	broad.mit.edu	37	15	89398710	89398710	+	Missense_Mutation	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:89398710C>T	ENST00000439576.2	+	12	3268	c.2894C>T	c.(2893-2895)aCc>aTc	p.T965I	ACAN_ENST00000561243.1_Missense_Mutation_p.T965I|ACAN_ENST00000559004.1_Missense_Mutation_p.T965I|ACAN_ENST00000352105.7_Missense_Mutation_p.T965I	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	965					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GTTCTAGAGACCTCTGCCTCT	0.562000													5	226					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121746844	121746844	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:121746844C>T	ENST00000452319.1	+	14	3414	c.3354C>T	c.(3352-3354)ggC>ggT	p.G1118G	GLI2_ENST00000361492.4_Silent_p.G1118G|GLI2_ENST00000314490.11_Silent_p.G790G			P10070	GLI2_HUMAN	GLI family zinc finger 2	1118					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCAACGTGGGCCCCTCCGCCC	0.622000													33	62					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605984	47605984	+	Missense_Mutation	SNP	C	C	T	rs9600		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:47605984C>T	ENST00000263774.4	+	7	828	c.746C>T	c.(745-747)cCg>cTg	p.P249L	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	249			P -> Q (in dbSNP:rs9600).		induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	CGCCAACCCCCGGAGAGTCTC	0.567000													61	190					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	58					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328050	126328050	+	Missense_Mutation	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr4:126328050G>A	ENST00000394329.3	+	3	5336	c.5323G>A	c.(5323-5325)Gtc>Atc	p.V1775I	FAT4_ENST00000335110.5_Missense_Mutation_p.V73I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1775	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAATGCTCTCGTCACATACAC	0.433000													17	127					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58545390	58545390	+	Silent	SNP	G	G	A			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:58545390G>A	ENST00000394282.4	+	16	1493	c.1086G>A	c.(1084-1086)tcG>tcA	p.S362S	NDRG4_ENST00000569923.1_Silent_p.S255S|NDRG4_ENST00000568640.1_Silent_p.S328S|NDRG4_ENST00000356752.4_Silent_p.S340S|NDRG4_ENST00000562999.1_Silent_p.S298S|NDRG4_ENST00000566192.1_Silent_p.S310S|NDRG4_ENST00000563799.1_Silent_p.S328S|NDRG4_ENST00000570248.1_Silent_p.S323S|NDRG4_ENST00000394279.2_Silent_p.S342S|NDRG4_ENST00000258187.5_Silent_p.S342S	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	323					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						GTGCCAGCTCGGTGGATGGCA	0.657000													4	136					0	0	1	0	0
CERKL	0	broad.mit.edu	37	2	182468750	182468751	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:182468750_182468751delAT	ENST00000410087.3	-	2	394_395	c.294_295delAT	c.(292-297)attcfs	p.IF98fs	CERKL_ENST00000479558.1_5'UTR|CERKL_ENST00000409440.3_Frame_Shift_Del_p.IF98fs|CERKL_ENST00000374969.2_Frame_Shift_Del_p.IF98fs|CERKL_ENST00000374970.2_Frame_Shift_Del_p.IF98fs|CERKL_ENST00000339098.5_Frame_Shift_Del_p.IF98fs	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	98					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTCACAGAGAATATGTCTTTGA	0.307													19	34	---	---	---	---					
ABCA12	26154	broad.mit.edu	37	2	215843155	215843156	+	Frame_Shift_Ins	INS	-	-	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr2:215843155_215843156insT	ENST00000272895.7	-	33	5231_5232	c.5012_5013insA	c.(5011-5013)aagfs	p.K1671fs	ABCA12_ENST00000389661.4_Frame_Shift_Ins_p.K1353fs	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1671					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATAGCACTATTTTTTTGTGA	0.376													7	23	---	---	---	---					
RP11-553L6.2	0	broad.mit.edu	37	3	113951738	113951739	+	RNA	INS	-	-	CC	rs60004852	by1000genomes	TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr3:113951738_113951739insCC	ENST00000493033.1	+	0	160				RP11-553L6.2_ENST00000481773.1_RNA																							ACTGCCCCCTGCCCCCCCCCCA	0.653													4	3	---	---	---	---					
SAMD3	154075	broad.mit.edu	37	6	130535491	130535491	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr6:130535491delG	ENST00000532763.1	-	3	389	c.260delC	c.(259-261)gafs	p.A88fs	SAMD3_ENST00000437477.2_Frame_Shift_Del_p.A88fs|SAMD3_ENST00000368134.2_Frame_Shift_Del_p.A88fs|SAMD3_ENST00000324172.6_Frame_Shift_Del_p.A88fs|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000439090.2_Frame_Shift_Del_p.A88fs|SAMD3_ENST00000457563.2_Frame_Shift_Del_p.A112fs			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	88										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTCTCGAGCTGCTTCTGTTTG	0.428													12	197	---	---	---	---					
FJX1	24147	broad.mit.edu	37	11	35640220	35640220	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr11:35640220delG	ENST00000317811.4	+	1	486	c.36delG	c.(34-36)gcfs	p.A12fs		NM_014344.3	NP_055159.2	Q86VR8	FJX1_HUMAN	four jointed box 1 (Drosophila)	12						extracellular space				lung(1)|urinary_tract(1)	2	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				CCGCCACCGCGGGGCTCTGGC	0.801													2	4	---	---	---	---					
MLH3	27030	broad.mit.edu	37	14	75514337	75514338	+	Frame_Shift_Ins	INS	-	-	T			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr14:75514337_75514338insT	ENST00000355774.2	-	2	2236_2237	c.2021_2022insA	c.(2020-2022)atgfs	p.M674fs	MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000238662.7_Frame_Shift_Ins_p.M674fs|MLH3_ENST00000556740.1_Frame_Shift_Ins_p.M674fs|MLH3_ENST00000556257.1_Frame_Shift_Ins_p.M674fs	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	674					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TCGTTCTGCAATTTTTTTTGTT	0.347								Mismatch excision repair (MMR)					26	48	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													3	3	---	---	---	---					
CACNA1H	8912	broad.mit.edu	37	16	1259227	1259227	+	Frame_Shift_Del	DEL	G	G	-			TCGA-H9-A6BY-01A-11D-A30E-08	TCGA-H9-A6BY-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e25c1b9-c691-44c5-bc32-85ddca3e1196	57d5137e-6a41-4e03-a279-e4ee1cf06472	g.chr16:1259227delG	ENST00000348261.5	+	17	3807	c.3559delG	c.(3559-3561)ggfs	p.G1187fs	CACNA1H_ENST00000358590.4_Frame_Shift_Del_p.G1187fs|CACNA1H_ENST00000565831.1_Frame_Shift_Del_p.G1187fs	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1187					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCCGCGCCCGGGCCCCGTGC	0.761													2	4	---	---	---	---					
