Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OSGEPL1	64172	broad.mit.edu	37	2	190626231	190626231	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:190626231A>G	ENST00000519810.1	-	3	478	c.136T>C	c.(136-138)Tgt>Cgt	p.C46R	OSGEPL1_ENST00000264151.5_Missense_Mutation_p.C46R|OSGEPL1_ENST00000522700.1_Missense_Mutation_p.C46R			Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	46					proteolysis|tRNA processing		metalloendopeptidase activity			large_intestine(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			GTATCATCACAACTAGTTTCA	0.318000													3	73					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6702291	6702291	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr12:6702291T>C	ENST00000309577.6	-	17	2781	c.2618A>G	c.(2617-2619)gAt>gGt	p.D873G	CHD4_ENST00000544484.1_Missense_Mutation_p.D870G|CHD4_ENST00000544040.1_Missense_Mutation_p.D866G|CHD4_ENST00000357008.2_Missense_Mutation_p.D873G			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	873	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATGGGCTTCATCCACGATGAG	0.473000													7	44					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482633	23482633	+	Splice_Site	SNP	G	G	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:23482633G>T	ENST00000376504.3	+	2	989	c.784_splice	c.e2-1	p.R262_splice		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	262					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						ACCTGTCCAGGGTCCCCCTCC	0.507000													6	151					3.59834e-05	3.80396e-05	1	1	0
MET	0	broad.mit.edu	37	7	116399499	116399499	+	Silent	SNP	G	G	A	rs141733128	by1000genomes	TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr7:116399499G>A	ENST00000397752.3	+	10	2519	c.2319G>A	c.(2317-2319)ccG>ccA	p.P773P	MET_ENST00000436117.2_Intron|MET_ENST00000318493.6_Silent_p.P791P	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	773	IPT/TIG 3.		P -> L (in gastric cancer).		axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTAGTGTCCCGAGAATGGTCA	0.433000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				5	14					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23436137	23436137	+	Silent	SNP	C	C	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:23436137C>A	ENST00000307149.5	-	7	1127	c.942G>T	c.(940-942)ctG>ctT	p.L314L		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	314					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		AGAACTCCAGCAGCCTGGTGA	0.637000													24	59					2.21704e-12	2.44867e-12	1	1	0
DOCK1	1793	broad.mit.edu	37	10	129224169	129224169	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:129224169A>G	ENST00000280333.6	+	47	4854	c.4745A>G	c.(4744-4746)cAt>cGt	p.H1582R		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1582	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		ATCAGAATCCATGGAGACAAA	0.498000													37	89					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144783990	144783990	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr6:144783990C>T	ENST00000367545.3	+	22	3054	c.3054C>T	c.(3052-3054)ctC>ctT	p.L1018L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1018					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTCTCACACTCAGAGCTTTTG	0.338000													12	54					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579005	55579005	+	Silent	SNP	T	T	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr11:55579005T>A	ENST00000333973.2	+	1	152	c.63T>A	c.(61-63)ccT>ccA	p.P21P		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				CAGATGTCCCTGAGTTGAGAG	0.473000													48	118					0	0	1	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995629	57995629	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr11:57995629C>T	ENST00000316770.2	-	1	761	c.719G>A	c.(718-720)cGc>cAc	p.R240H		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				GAAGGCCCGGCGGCGGCCCTC	0.632000													7	46					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612175	189612175	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr3:189612175C>T	ENST00000264731.3	+	14	2016	c.1927C>T	c.(1927-1929)Cga>Tga	p.R643*	TP63_ENST00000382063.4_Nonsense_Mutation_p.R558*|TP63_ENST00000456148.1_Nonsense_Mutation_p.R545*|TP63_ENST00000449992.1_Nonsense_Mutation_p.R464*|TP63_ENST00000440651.2_Nonsense_Mutation_p.R639*|TP63_ENST00000354600.5_Nonsense_Mutation_p.R549*|TP63_ENST00000320472.5_3'UTR	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	643	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGATGCTGTGCGATTCACCCT	0.552000										HNSCC(45;0.13)			9	39					0	0	1	0	0
TMEM192	201931	broad.mit.edu	37	4	166021832	166021832	+	Silent	SNP	G	G	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:166021832G>T	ENST00000306480.5	-	3	532	c.387C>A	c.(385-387)atC>atA	p.I129I	TMEM192_ENST00000506087.1_Silent_p.I125I	NM_001100389.1	NP_001093859.1	Q8IY95	TM192_HUMAN	transmembrane protein 192	129						Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		TTGATCGGTAGATCAAGTTAT	0.413000													14	45					4.3838e-07	4.77061e-07	1	1	0
KL	9365	broad.mit.edu	37	13	33629460	33629460	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr13:33629460A>G	ENST00000426690.2	+	3	1033	c.686A>G	c.(685-687)cAg>cGg	p.Q229R	KL_ENST00000487852.1_3'UTR|KL_ENST00000380099.3_Intron			Q9UEF7	KLOT_HUMAN	klotho	536	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CAAGTAAGTCAGCTGACAAAA	0.458000													3	35					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													3	31					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47788869	47788869	+	Silent	SNP	G	G	T	rs61764289		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:47788869G>T	ENST00000273857.4	-	3	281	c.282C>A	c.(280-282)tcC>tcA	p.S94S	CORIN_ENST00000504584.1_Silent_p.S94S|CORIN_ENST00000508498.1_5'UTR|CORIN_ENST00000505909.1_Silent_p.S94S|CORIN_ENST00000502252.1_Intron	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	94					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GAATAACATCGGACCCTTGGA	0.408000													3	35					1	1	1	1	0
SPOP	8405	broad.mit.edu	37	17	47696425	47696425	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr17:47696425A>C	ENST00000393331.3	-	7	868	c.398T>G	c.(397-399)tTc>tGc	p.F133C	SPOP_ENST00000347630.2_Missense_Mutation_p.F133C|SPOP_ENST00000504102.1_Missense_Mutation_p.F133C|SPOP_ENST00000503676.1_Missense_Mutation_p.F133C|SPOP_ENST00000393328.2_Missense_Mutation_p.F133C	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	133	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F133C(3)|p.F133S(2)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						GAATTTCTTGAATCCCCAGTC	0.448000										Prostate(2;0.17)			38	94					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21441709	21441709	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr18:21441709G>T	ENST00000313654.9	+	35	4763	c.4522G>T	c.(4522-4524)Gag>Tag	p.E1508*	LAMA3_ENST00000399516.3_Nonsense_Mutation_p.E1508*	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1508	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGATCTCCAGGAGCTGCCCGC	0.597000													3	20					0.004672	0.004736	1	1	0
CAB39	51719	broad.mit.edu	37	2	231663527	231663527	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:231663527T>C	ENST00000258418.5	+	5	911	c.482T>C	c.(481-483)tTg>tCg	p.L161S	CAB39_ENST00000410084.3_Missense_Mutation_p.L161S|CAB39_ENST00000409788.3_Missense_Mutation_p.L161S	NM_016289.3	NP_057373.1	Q9Y376	CAB39_HUMAN	calcium binding protein 39	161					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)|large_intestine(1)|skin(1)	3		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		AAAATCATTTTGTGGTCGGAA	0.338000													16	37					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030039	197030039	+	Silent	SNP	T	T	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr1:197030039T>A	ENST00000367412.1	-	4	661	c.618A>T	c.(616-618)ccA>ccT	p.P206P		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	206	Sushi 3.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TGGTACATTTTGGTGTGAGAG	0.393000													23	52					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102305092	102305092	+	RNA	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr15:102305092A>G	ENST00000561463.1	+	0	13138																											CATGAACACCATCAGCACAGC	0.632000													4	20					0	0	1	0	0
ZNF688	146542	broad.mit.edu	37	16	30581273	30581273	+	Silent	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:30581273G>A	ENST00000223459.6	-	3	1899	c.795C>T	c.(793-795)ttC>ttT	p.F265F	ZNF688_ENST00000395219.1_Silent_p.F251F	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						GGTAGTGCCGGAAGAGCACAG	0.711000													15	33					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15986477	15986477	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr1:15986477C>T	ENST00000345034.1	+	1	114	c.114C>T	c.(112-114)tgC>tgT	p.C38C	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	38					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCAGTCTGCCCTATCAAGC	0.473000													5	152					0	0	1	0	0
G6PC3	92579	broad.mit.edu	37	17	42152704	42152704	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr17:42152704C>A	ENST00000269097.4	+	5	793	c.562C>A	c.(562-564)Ccc>Acc	p.P188T		NM_138387.3	NP_612396.1	Q9BUM1	G6PC3_HUMAN	glucose 6 phosphatase, catalytic, 3	188					gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	11		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCTGATGACTCCCCGAGTGCC	0.597000													14	27					2.31682e-05	2.48471e-05	1	1	0
UGT2B7	7364	broad.mit.edu	37	4	69962788	69962788	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:69962788A>G	ENST00000305231.7	+	1	596	c.550A>G	c.(550-552)Agt>Ggt	p.S184G	UGT2B7_ENST00000509763.1_Intron|UGT2B7_ENST00000508661.1_Missense_Mutation_p.S184G	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	184					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGAAAAGCATAGTGGAGGATT	0.393000													29	89					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85212902	85212902	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chrX:85212902T>C	ENST00000357749.2	-	7	927	c.898A>G	c.(898-900)Aca>Gca	p.T300A	CHM_ENST00000467744.1_Intron|CHM_ENST00000537751.1_Missense_Mutation_p.T152A	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	300					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				ATACAAAATGTAAGAAATTTC	0.274000													23	11					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	35					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241726712	241726712	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:241726712G>A	ENST00000498729.2	-	5	631	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	KIF1A_ENST00000320389.7_Missense_Mutation_p.R129W	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	129	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TCGTTGATCCGAGAGAAGAGG	0.652000													15	32					0	0	1	0	0
RPS9	6203	broad.mit.edu	37	19	54710321	54710321	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr19:54710321G>C	ENST00000402367.1	+	4	513	c.398G>C	c.(397-399)cGc>cCc	p.R133P	RPS9_ENST00000391752.1_Missense_Mutation_p.R133P|RPS9_ENST00000391751.3_Intron|RPS9_ENST00000302907.4_Missense_Mutation_p.R133P|RPS9_ENST00000441429.1_Missense_Mutation_p.R133P|RPS9_ENST00000391753.2_Missense_Mutation_p.R133P			P46781	RS9_HUMAN	ribosomal protein S9	133	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			NS(1)|breast(1)|kidney(11)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	20	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		ATCCGCCAGCGCCATATCAGG	0.577000													4	17					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748174	8748174	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:8748174G>A	ENST00000276282.6	-	1	2981	c.2395C>T	c.(2395-2397)Cca>Tca	p.P799S		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	799										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		ACATGAGCTGGCAAGAGCCCA	0.602000													19	39					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3208477	3208477	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:3208477T>C	ENST00000380989.2	-	4	400	c.362A>G	c.(361-363)gAc>gGc	p.D121G	PITRM1_ENST00000451104.2_Missense_Mutation_p.D89G|PITRM1_ENST00000224949.4_Missense_Mutation_p.D121G|PITRM1-AS1_ENST00000598280.1_RNA	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	89					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						GAAGAAAGGGTCTCTGCACGG	0.498000													34	67					0	0	1	0	0
MAP3K8	1326	broad.mit.edu	37	10	30739283	30739283	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:30739283G>A	ENST00000263056.1	+	5	1297	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	MAP3K8_ENST00000375321.1_Missense_Mutation_p.E201K|MAP3K8_ENST00000542547.1_Missense_Mutation_p.E201K	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	201	Protein kinase.				cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				CCTGTGGGGTGAAACTGTCCA	0.493000													19	46					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3658512	3658512	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:3658512C>G	ENST00000294008.3	-	2	1094	c.454G>C	c.(454-456)Gtg>Ctg	p.V152L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	152	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TCCCGGAGCACAGGTGGATCT	0.502000								Direct reversal of damage					19	39					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133636429	133636429	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:133636429G>T	ENST00000409261.1	-	9	1013	c.640C>A	c.(640-642)Ctt>Att	p.L214I	NCKAP5_ENST00000409213.1_Missense_Mutation_p.L214I|NCKAP5_ENST00000405974.3_Missense_Mutation_p.L214I|NCKAP5_ENST00000317721.6_Missense_Mutation_p.L214I	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	214							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						ACCTCATCAAGACATCGCTCA	0.418000													7	17					8.12818e-05	8.47163e-05	1	1	0
EPB41L2	2037	broad.mit.edu	37	6	131277399	131277399	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr6:131277399C>T	ENST00000337057.3	-	2	408	c.227G>A	c.(226-228)cGg>cAg	p.R76Q	EPB41L2_ENST00000527411.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000529208.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000445890.2_Missense_Mutation_p.R76Q|EPB41L2_ENST00000525271.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000528282.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000525193.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000527659.1_Missense_Mutation_p.R76Q|EPB41L2_ENST00000530148.1_Intron|EPB41L2_ENST00000392427.3_Missense_Mutation_p.R76Q|EPB41L2_ENST00000368128.2_Missense_Mutation_p.R76Q|EPB41L2_ENST00000530481.1_Missense_Mutation_p.R76Q	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	76					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CGGTATGAACCGAGAAATACC	0.478000													9	95					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25364244	25364244	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:25364244A>C	ENST00000330560.3	+	15	2539	c.2062A>C	c.(2062-2064)Aat>Cat	p.N688H	CDCA2_ENST00000380665.3_Missense_Mutation_p.N673H|CDCA2_ENST00000521098.2_3'UTR	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	688					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		CATTAATGAAAATAAAAATAT	0.328000													15	50					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38182486	38182486	+	Silent	SNP	A	A	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr17:38182486A>T	ENST00000394126.1	-	18	2401	c.1983T>A	c.(1981-1983)cgT>cgA	p.R661R	MED24_ENST00000394127.2_Silent_p.R623R|MED24_ENST00000394128.2_Silent_p.R636R|MED24_ENST00000356271.3_Silent_p.R623R|MED24_ENST00000501516.3_Silent_p.R655R			O75448	MED24_HUMAN	mediator complex subunit 24	636					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					GCGACTTCTCACGCTCATCCA	0.552000													6	72					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107645339	107645339	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr9:107645339C>T	ENST00000374736.3	-	5	796	c.402G>A	c.(400-402)caG>caA	p.Q134Q	ABCA1_ENST00000423487.2_Silent_p.Q134Q|ABCA1_ENST00000374733.1_Silent_p.Q74Q	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	134					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATTTCTTGATCTGCTGTAATG	0.468000													8	103					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134743283	134743283	+	Missense_Mutation	SNP	G	G	A	rs141623050	byFrequency	TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:134743283G>A	ENST00000368586.5	-	9	992	c.892C>T	c.(892-894)Cgt>Tgt	p.R298C	TTC40_ENST00000368585.3_Missense_Mutation_p.R298C|TTC40_ENST00000368582.2_Missense_Mutation_p.R298C	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						AAGGAAAAACGCGCCAATTCA	0.493000													8	32					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32453407	32453407	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:32453407C>T	ENST00000341377.5	+	2	679	c.162C>T	c.(160-162)gtC>gtT	p.V54V	NRG1_ENST00000287840.5_Silent_p.V54V|NRG1_ENST00000521670.1_Silent_p.V54V|NRG1_ENST00000287842.3_Silent_p.V54V|NRG1_ENST00000287845.5_Silent_p.V54V|NRG1_ENST00000356819.4_Silent_p.V54V|NRG1_ENST00000523079.1_Silent_p.V54V|NRG1_ENST00000405005.2_Silent_p.V54V|NRG1_ENST00000520407.1_Silent_p.V269V|NRG1_ENST00000338921.4_Silent_p.V54V|NRG1_ENST00000519301.1_Silent_p.V33V			Q02297	NRG1_HUMAN	neuregulin 1	54	Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCAAACTAGTCCTTCGGTGTG	0.403000													5	104					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37267464	37267464	+	Silent	SNP	A	A	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr1:37267464A>T	ENST00000373091.3	-	16	2764	c.2748T>A	c.(2746-2748)ccT>ccA	p.P916P		NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	916					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGGGGAACACAGGGGCTAAGG	0.612000													3	33					0	0	1	0	0
PDGFA	0	broad.mit.edu	37	7	540867	540867	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr7:540867C>T	ENST00000402802.3	-	5	873	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	PDGFA_ENST00000354513.5_Missense_Mutation_p.E156K	NM_033023.4	NP_148983.1	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha polypeptide	156					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CTGACGTATTCCACCTTGGCC	0.567000													4	182					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74620343	74620343	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr18:74620343C>T	ENST00000253159.8	+	14	2557	c.2359C>T	c.(2359-2361)Cag>Tag	p.Q787*	ZNF236_ENST00000320610.9_Nonsense_Mutation_p.Q789*	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	787					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CACTGTAGACCAGCAGAGCAT	0.552000													7	165					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30694898	30694898	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:30694898C>T	ENST00000256246.2	-	3	7827	c.7753G>A	c.(7753-7755)Gat>Aat	p.D2585N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2585										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTCAATGTATCCTTCATGTAT	0.403000													23	66					0	0	1	0	0
RPS9	6203	broad.mit.edu	37	19	54710322	54710322	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr19:54710322C>T	ENST00000402367.1	+	4	514	c.399C>T	c.(397-399)cgC>cgT	p.R133R	RPS9_ENST00000391752.1_Silent_p.R133R|RPS9_ENST00000391751.3_Intron|RPS9_ENST00000302907.4_Silent_p.R133R|RPS9_ENST00000441429.1_Silent_p.R133R|RPS9_ENST00000391753.2_Silent_p.R133R			P46781	RS9_HUMAN	ribosomal protein S9	133	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			NS(1)|breast(1)|kidney(11)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	20	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		TCCGCCAGCGCCATATCAGGT	0.577000													4	17					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102305084	102305084	+	RNA	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr15:102305084T>C	ENST00000561463.1	+	0	13130																											GACATCAACATGAACACCATC	0.632000													4	16					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50005613	50005613	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr3:50005613C>T	ENST00000443081.1	+	3	1278	c.359C>T	c.(358-360)aCg>aTg	p.T120M	RBM6_ENST00000539992.1_Intron|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000266022.4_Missense_Mutation_p.T252M|RBM6_ENST00000422955.1_Intron			P78332	RBM6_HUMAN	RNA binding motif protein 6	252					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GACAGGGATACGCCACATTCA	0.438000													19	43					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733414	50733414	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:50733414C>T	ENST00000300589.2	+	2	194	c.89C>T	c.(88-90)tCg>tTg	p.S30L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	30	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GAAATGTGCTCGCAGGAGGCT	0.612000													4	133					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113812389	113812389	+	Splice_Site	SNP	A	A	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:113812389A>G	ENST00000297405.5	-	13	2217		c.e13+1		CSMD3_ENST00000343508.3_Splice_Site|CSMD3_ENST00000352409.3_Splice_Site|CSMD3_ENST00000455883.2_Splice_Site	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3							integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTAATCATTACCTTTGTAGT	0.338000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	36					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39847179	39847179	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr6:39847179G>A	ENST00000538976.1	+	14	1953	c.1771G>A	c.(1771-1773)Gtc>Atc	p.V591I	DAAM2_ENST00000274867.4_Missense_Mutation_p.V591I|DAAM2_ENST00000398904.2_Missense_Mutation_p.V591I	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	591	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					CAGCAGTGACGTCCCACTCAG	0.652000													16	61					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962451	69962451	+	Silent	SNP	T	T	C			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:69962451T>C	ENST00000305231.7	+	1	259	c.213T>C	c.(211-213)gcT>gcC	p.A71A	UGT2B7_ENST00000509763.1_Intron|UGT2B7_ENST00000508661.1_Silent_p.A71A	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	71			A -> S (in dbSNP:rs12233719).		lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ACTCATCCGCTCTTAAAATTG	0.373000													23	61					0	0	1	0	0
LRRC27	80313	broad.mit.edu	37	10	134165247	134165247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:134165247C>T	ENST00000368610.3	+	6	877	c.877C>T	c.(877-879)Cag>Tag	p.Q293*	LRRC27_ENST00000368614.3_Nonsense_Mutation_p.Q355*|LRRC27_ENST00000344079.5_3'UTR|LRRC27_ENST00000475747.1_3'UTR|LRRC27_ENST00000432555.2_Nonsense_Mutation_p.Q228*|LRRC27_ENST00000392638.2_3'UTR|LRRC27_ENST00000368612.1_Nonsense_Mutation_p.Q293*|LRRC27_ENST00000368613.4_Nonsense_Mutation_p.Q355*|LRRC27_ENST00000368615.3_Nonsense_Mutation_p.Q355*			Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27	355										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	18		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TCTGATGGAGCAGCAGAGACG	0.622000													6	72					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72685542	72685542	+	RNA	SNP	G	G	A	rs2539086		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr7:72685542G>A	ENST00000425256.1	-	0	116					NR_002164.1																						ACGTTACCATGACAAAAGCAG	0.463000													4	144					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	27					0	0	1	0	0
NDUFAF6	137682	broad.mit.edu	37	8	96070121	96070121	+	Missense_Mutation	SNP	C	C	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr8:96070121C>G	ENST00000396113.1	+	15	1732	c.682C>G	c.(682-684)Ctt>Gtt	p.L228V	NDUFAF6_ENST00000396111.2_Missense_Mutation_p.L228V|NDUFAF6_ENST00000286687.4_Intron|NDUFAF6_ENST00000542894.1_Missense_Mutation_p.L268V|NDUFAF6_ENST00000396124.4_Missense_Mutation_p.L320V			Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	320					biosynthetic process	mitochondrion	transferase activity										GAATACATTACTTCCATTATA	0.289000													21	64					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152552704	152552704	+	Splice_Site	SNP	T	T	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr6:152552704T>A	ENST00000367255.5	-	114	21464		c.e114-2		SYNE1_ENST00000448038.1_Splice_Site|SYNE1_ENST00000341594.5_Splice_Site|SYNE1_ENST00000265368.4_Splice_Site|SYNE1_ENST00000423061.1_Splice_Site|SYNE1_ENST00000356820.4_Splice_Site	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTAAAACCCTAAAAAAAAAG	0.338000										HNSCC(10;0.0054)			3	40					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71027139	71027139	+	Silent	SNP	C	C	T	rs138465768		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr3:71027139C>T	ENST00000318789.4	-	15	1713	c.1188G>A	c.(1186-1188)tcG>tcA	p.S396S	FOXP1_ENST00000484350.1_Silent_p.S320S|FOXP1_ENST00000491238.1_Silent_p.S398S|FOXP1_ENST00000493089.1_Silent_p.S396S|FOXP1_ENST00000475937.1_Silent_p.S396S|FOXP1_ENST00000468577.1_Silent_p.S396S|FOXP1_ENST00000498215.1_Silent_p.S396S	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	396					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GAGAAGCCTCCGATGCGGACT	0.532000			T	PAX5	ALL								34	64					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224169	248224169	+	Silent	SNP	T	T	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr1:248224169T>G	ENST00000359959.3	+	1	186	c.186T>G	c.(184-186)ctT>ctG	p.L62L	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L62L(1)		cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATTTCCTACTTAGTCAGCTCT	0.408000													4	295					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48845943	48845943	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr19:48845943C>T	ENST00000293261.3	-	6	1135	c.819G>A	c.(817-819)acG>acA	p.T273T	TMEM143_ENST00000435956.3_Silent_p.T238T|TMEM143_ENST00000377431.2_Silent_p.T173T|TMEM143_ENST00000541566.1_Silent_p.T163T|TMEM143_ENST00000436660.2_Silent_p.T208T	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	273						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GCAGGGTGGGCGTGCGCACCT	0.642000													6	16					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887198	25887198	+	Silent	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr10:25887198C>T	ENST00000376351.3	+	11	3002	c.2643C>T	c.(2641-2643)agC>agT	p.S881S	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	881						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AGTCAGCAAGCGCTCACAACC	0.502000													24	69					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110081568	110081568	+	Missense_Mutation	SNP	T	T	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr6:110081568T>G	ENST00000230124.3	+	11	1377	c.1253T>G	c.(1252-1254)aTg>aGg	p.M418R	FIG4_ENST00000441478.2_Missense_Mutation_p.M141R	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	418	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CCCTGGGACATGGCCAAGTAT	0.408000													4	62					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119059263	119059263	+	Missense_Mutation	SNP	G	G	A	rs150758016	byFrequency	TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:119059263G>A	ENST00000296499.5	+	5	1682	c.1279G>A	c.(1279-1281)Gtc>Atc	p.V427I	NDST3_ENST00000433996.2_Missense_Mutation_p.V346I	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	427	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity	p.V427I(3)		NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CCATTCGGGCGTCTACCCTGT	0.468000													24	44					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27147850	27147850	+	Silent	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:27147850G>A	ENST00000288699.6	+	3	515	c.357G>A	c.(355-357)ctG>ctA	p.L119L	DPYSL5_ENST00000401478.1_Silent_p.L119L	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	119					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCGAGGTCTGGCCGACCCCA	0.617000													9	13					0	0	1	0	0
IRAK3	0	broad.mit.edu	37	12	66620595	66620595	+	Missense_Mutation	SNP	T	T	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr12:66620595T>A	ENST00000261233.4	+	7	1167	c.746T>A	c.(745-747)cTt>cAt	p.L249H	IRAK3_ENST00000457197.2_Missense_Mutation_p.L188H	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	249	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		AATGGAACACTTTTTGACAGA	0.418000													11	21					0	0	1	0	0
KANSL3	55683	broad.mit.edu	37	2	97276875	97276875	+	Splice_Site	SNP	C	C	G			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:97276875C>G	ENST00000599854.1	-	10	1293	c.825_splice	c.e10-1	p.V276_splice	KANSL3_ENST00000431828.1_Splice_Site_p.V363_splice|KANSL3_ENST00000441706.2_Splice_Site_p.V276_splice|KANSL3_ENST00000440133.1_Splice_Site_p.V157_splice|KANSL3_ENST00000487070.1_5'UTR	NM_001115016.2	NP_001108488.1	Q9P2N6	K1310_HUMAN	KAT8 regulatory NSL complex subunit 3	363																	ATTACTGACACCTGTAAATAA	0.498000													10	38					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819729	110819729	+	Silent	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr5:110819729G>A	ENST00000282356.4	+	11	1385	c.987G>A	c.(985-987)gcG>gcA	p.A329A	CAMK4_ENST00000512453.1_Silent_p.A329A|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	329	Calmodulin-binding (Potential).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATCAGGCAGCGGTGAAGGCTG	0.547000													18	19					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81224300	81224300	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr15:81224300G>A	ENST00000394685.3	+	22	3132	c.2713G>A	c.(2713-2715)Gcc>Acc	p.A905T	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000220244.3_Missense_Mutation_p.A905T|KIAA1199_ENST00000356249.5_Missense_Mutation_p.A905T			Q8WUJ3	K1199_HUMAN	KIAA1199	905										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GCACACCAGCGCCCTGGCCTT	0.552000													36	81					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104750743	104750743	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr7:104750743G>T	ENST00000334877.4	+	24	4306	c.3772G>T	c.(3772-3774)Gtg>Ttg	p.V1258L	KMT2E_ENST00000257745.4_Missense_Mutation_p.V1258L|KMT2E_ENST00000311117.3_Missense_Mutation_p.V1258L|KMT2E_ENST00000334914.7_Missense_Mutation_p.V313L					lysine (K)-specific methyltransferase 2E																		CTCAACTTCAGTGGAACAAGT	0.378000													8	61					0.00448238	0.00460689	1	1	0
CECR5	27440	broad.mit.edu	37	22	17621968	17621968	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr22:17621968C>T	ENST00000336737.4	-	6	752	c.727G>A	c.(727-729)Gct>Act	p.A243T	CECR5_ENST00000155674.5_Missense_Mutation_p.A213T|CECR5_ENST00000399852.3_Missense_Mutation_p.A106T	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	243							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				TTGGCTTCAGCCATCCACAGG	0.632000													3	36					0	0	1	0	0
SAMD11	148398	broad.mit.edu	37	1	877557	877557	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr1:877557delC	ENST00000342066.3	+	9	994	c.911delC	c.(910-912)gcfs	p.A304fs		NM_152486.2	NP_689699.2	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	304						nucleus				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCGCAGAATGCCCCTCACGTC	0.736													2	4	---	---	---	---					
ASNSD1	54529	broad.mit.edu	37	2	190531908	190531910	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr2:190531908_190531910delTCT	ENST00000260952.4	+	4	1463_1465	c.1050_1052delTCT	c.(1048-1053)gat>ga	p.DL350del	ASNSD1_ENST00000607062.1_Intron	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	350	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AACCAATTGATCTTCTTAATGTA	0.369													27	97	---	---	---	---					
RP11-242J7.1	0	broad.mit.edu	37	4	185536410	185536413	+	RNA	DEL	TTTG	TTTG	-	rs146473442		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr4:185536410_185536413delTTTG	ENST00000522554.1	-	0	292																											CAAAGCCGATtttgtttgtttgtt	0.451													3	3	---	---	---	---					
DPY19L2P1	0	broad.mit.edu	37	7	35145789	35145793	+	RNA	DEL	CTAAA	CTAAA	-	rs76141590		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr7:35145789_35145793delCTAAA	ENST00000436258.1	-	0	1553_1557																											GTGACTATCTCTAAACTACTTAGGA	0.190													3	5	---	---	---	---					
PEAK1	79834	broad.mit.edu	37	15	77473916	77473918	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr15:77473916_77473918delTTG	ENST00000560626.2	-	4	826_828	c.351_353delCAA	c.(349-354)aat>aa	p.NN119del	PEAK1_ENST00000312493.4_In_Frame_Del_p.NN119del|PEAK1_ENST00000558305.1_In_Frame_Del_p.NN119del			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	119	Poly-Asn.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TTCATTATTATTGTTAAGTGGTT	0.389													35	131	---	---	---	---					
Z84812.4	0	broad.mit.edu	37	16	79576	79581	+	RNA	DEL	GTTGTT	GTTGTT	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:79576_79581delGTTGTT	ENST00000568710.1	-	0	434																											AGGCACAGTAGTtgttgttgttgctg	0.641													3	4	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	21082111	21082111	+	Frame_Shift_Del	DEL	T	T	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:21082111delT	ENST00000261383.3	-	22	3120	c.3121delA	c.(3121-3123)tgfs	p.M1041fs	DNAH3_ENST00000415178.1_Frame_Shift_Del_p.M1041fs	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1041	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCAAGTAGCATTTGAATGTCA	0.408													30	77	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372914	74372914	+	RNA	DEL	G	G	-	rs67181940		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:74372914delG	ENST00000429810.2	-	0	1404																											AACGTAGtttgtttttttttt	0.433													2	4	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													3	3	---	---	---	---					
TBC1D3P1-DHX40P1	0	broad.mit.edu	37	17	58090681	58090681	+	RNA	DEL	T	T	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr17:58090681delT	ENST00000407042.3	-	0	609																											CTCTGAATGATTTTTTTTTTT	0.458													3	5	---	---	---	---					
ERN1	2081	broad.mit.edu	37	17	62130676	62130676	+	Frame_Shift_Del	DEL	T	T	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chr17:62130676delT	ENST00000433197.2	-	16	2104	c.2009delA	c.(2008-2010)cgfs	p.Q671fs		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	671	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						GGTGGTCTGCTGCAGCAAGGT	0.612													13	37	---	---	---	---					
FAM47B	170062	broad.mit.edu	37	X	34962650	34962652	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-J4-A83J-01A-11D-A364-08	TCGA-J4-A83J-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26425bd7-6764-40d8-bfc9-fe8738359cc2	1da444be-497e-4cd9-96a8-1643c6f3d878	g.chrX:34962650_34962652delATT	ENST00000329357.5	+	1	1738_1740	c.1702_1704delATT	c.(1702-1704)del	p.I568del		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	568										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TGAACCTTTGATTGACCCCAAGC	0.463													49	30	---	---	---	---					
