Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF106	64397	broad.mit.edu	37	15	42720231	42720231	+	Silent	SNP	G	G	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr15:42720231G>T	ENST00000263805.4	-	12	5240	c.4914C>A	c.(4912-4914)gtC>gtA	p.V1638V	ZNF106_ENST00000565611.1_Silent_p.V823V|ZNF106_ENST00000565380.1_Silent_p.V866V	NM_022473.1	NP_071918.1			zinc finger protein 106																		TGTTGAAGGTGACCACAGTGC	0.522000													4	146					0.00024832	0.000260145	1	1	0
ANKRD55	79722	broad.mit.edu	37	5	55407577	55407577	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:55407577C>T	ENST00000341048.4	-	10	1149	c.998G>A	c.(997-999)aGc>aAc	p.S333N	ANKRD55_ENST00000434982.2_Missense_Mutation_p.S45N|ANKRD55_ENST00000505970.2_5'UTR|ANKRD55_ENST00000504958.2_Missense_Mutation_p.S290N	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	332										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GGGCCGACTGCTCTGGGAGGG	0.488000													11	207					0	0	1	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70940179	70940179	+	Silent	SNP	C	C	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr10:70940179C>T	ENST00000359655.4	+	1	192	c.132C>T	c.(130-132)gtC>gtT	p.V44V	SUPV3L1_ENST00000483572.1_3'UTR	NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	44					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AAGTTTCTGTCCTTGCCACCG	0.667000													28	77					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196737041	196737041	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr2:196737041C>A	ENST00000312428.6	-	40	6666	c.6566G>T	c.(6565-6567)gGt>gTt	p.G2189V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2189	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CAAACAAACACCTTGAATGAC	0.383000													9	109					3.09899e-07	3.32574e-07	1	1	0
NBAS	51594	broad.mit.edu	37	2	15415631	15415631	+	Missense_Mutation	SNP	A	A	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr2:15415631A>C	ENST00000281513.5	-	44	5726	c.5701T>G	c.(5701-5703)Ttt>Gtt	p.F1901V	NBAS_ENST00000441750.1_Missense_Mutation_p.F1781V	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1901										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TTTGGAGAAAATGTAACTGCA	0.403000													14	45					0	0	1	0	0
PDZD8	118987	broad.mit.edu	37	10	119078421	119078421	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr10:119078421T>C	ENST00000334464.5	-	3	1299	c.1060A>G	c.(1060-1062)Agt>Ggt	p.S354G		NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	354					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		TCCCAAACACTACTGCTTAAC	0.328000													22	38					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24535310	24535310	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:24535310A>G	ENST00000264463.4	-	5	1232	c.725T>C	c.(724-726)aTg>aCg	p.M242T		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	242	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTGGCCGCCCATGTCTTTGGC	0.478000										HNSCC(23;0.051)			23	58					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60061727	60061727	+	Splice_Site	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr17:60061727T>C	ENST00000397786.2	-	15	2769	c.2691_splice	c.e15-1	p.D898_splice		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	898					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATAAGAAAAATCCTACAATAT	0.348000													15	31					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86305380	86305380	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr2:86305380G>C	ENST00000263857.6	-	10	1492	c.1114C>G	c.(1114-1116)Cga>Gga	p.R372G	POLR1A_ENST00000409681.1_Missense_Mutation_p.R372G			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	372					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						AAAAAGGATCGGTCAATAGCA	0.403000													7	65					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216243582	216243582	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr1:216243582G>C	ENST00000366943.2	-	30	6296	c.5910C>G	c.(5908-5910)agC>agG	p.S1970R	USH2A_ENST00000307340.3_Missense_Mutation_p.S1970R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1970	Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCACCTCAATGCTGTATCCAT	0.478000										HNSCC(13;0.011)			3	67					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720454	50720454	+	Silent	SNP	C	C	G			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr22:50720454C>G	ENST00000449103.1	-	20	3314	c.3174G>C	c.(3172-3174)ccG>ccC	p.P1058P	PLXNB2_ENST00000359337.4_Silent_p.P1058P			O15031	PLXB2_HUMAN	plexin B2	1058	IPT/TIG 3.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGCACAGCCGGGGACAGGA	0.647000													13	26					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50782019	50782019	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr15:50782019A>G	ENST00000433963.1	+	14	2412	c.1912A>G	c.(1912-1914)Aga>Gga	p.R638G	USP8_ENST00000396444.3_Missense_Mutation_p.R638G|USP8_ENST00000307179.4_Missense_Mutation_p.R638G|USP8_ENST00000425032.3_Missense_Mutation_p.R532G	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	638					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		ACCTTTGACAAGAGCACGAAG	0.323000													10	23					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73487841	73487841	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr17:73487841C>T	ENST00000314256.7	+	14	1850	c.1456C>T	c.(1456-1458)Cgt>Tgt	p.R486C	KIAA0195_ENST00000375248.5_Missense_Mutation_p.R496C|KIAA0195_ENST00000579208.1_Missense_Mutation_p.R137C	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	486					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGAGCAGGAGCGTGGCGACTG	0.617000													11	29					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4006973	4006973	+	Missense_Mutation	SNP	C	C	T	rs35393929		TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr7:4006973C>T	ENST00000404826.2	+	10	1592	c.1453C>T	c.(1453-1455)Cgg>Tgg	p.R485W	SDK1_ENST00000389531.3_Missense_Mutation_p.R485W	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	485	Ig-like C2-type 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTTCACCCAGCGGCCAGTGGA	0.547000													6	94					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150404109	150404109	+	Missense_Mutation	SNP	C	C	G	rs112279628		TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr3:150404109C>G	ENST00000295910.6	-	4	638	c.586G>C	c.(586-588)Gaa>Caa	p.E196Q	FAM194A_ENST00000491361.1_Missense_Mutation_p.E50Q	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	196										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GCCAGACATTCAGGTTCAGCT	0.388000													19	78					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8380302	8380302	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr17:8380302G>A	ENST00000360416.3	-	42	5909	c.5771C>T	c.(5770-5772)gCg>gTg	p.A1924V	NDEL1_ENST00000299734.7_Intron|MYH10_ENST00000396239.1_Missense_Mutation_p.A1914V|MYH10_ENST00000379980.4_Missense_Mutation_p.A1909V|MYH10_ENST00000269243.4_Missense_Mutation_p.A1893V	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	1893					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GGCACGCGTCGCTTCTTCTTC	0.572000													20	48					0	0	1	0	0
IL22	50616	broad.mit.edu	37	12	68642636	68642636	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr12:68642636G>C	ENST00000538666.1	-	6	553	c.483C>G	c.(481-483)atC>atG	p.I161M	IL22_ENST00000328087.4_Missense_Mutation_p.I161M			Q9GZX6	IL22_HUMAN	interleukin 22	161					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	14		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		CAATTGCTTTGATCTCTCCAC	0.368000													7	205					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36976330	36976330	+	Missense_Mutation	SNP	A	A	C	rs144853101		TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:36976330A>C	ENST00000282516.8	+	9	1820	c.1321A>C	c.(1321-1323)Act>Cct	p.T441P	NIPBL_ENST00000448238.2_Missense_Mutation_p.T441P|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	441	Gln-rich.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ACAACAGAACACTTCAGTTGC	0.413000													27	59					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56720445	56720445	+	Silent	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr12:56720445T>C	ENST00000425394.2	-	7	1594	c.1218A>G	c.(1216-1218)acA>acG	p.T406T	PAN2_ENST00000257931.5_Silent_p.T406T|PAN2_ENST00000440411.3_Silent_p.T406T|PAN2_ENST00000548043.1_Silent_p.T406T	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	406					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CAGAGAGAAGTGTGTCAGTGG	0.587000													11	25					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155219735	155219735	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr4:155219735G>T	ENST00000357232.3	-	18	4365	c.4366C>A	c.(4366-4368)Cca>Aca	p.P1456T		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1456	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTCCTAGGTGGATCTCCCAGG	0.458000													49	97					6.68952e-21	7.95511e-21	1	1	0
CLOCK	9575	broad.mit.edu	37	4	56304467	56304467	+	Silent	SNP	T	T	G			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr4:56304467T>G	ENST00000309964.4	-	21	2593	c.2343A>C	c.(2341-2343)ccA>ccC	p.P781P	CLOCK_ENST00000381322.1_Silent_p.P781P|CLOCK_ENST00000513440.1_Silent_p.P781P	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	781					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			ATTGTTGCGGTGGCTGGGTCA	0.468000													25	44					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33068460	33068460	+	Silent	SNP	T	T	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr20:33068460T>A	ENST00000374864.4	+	19	2088	c.1875T>A	c.(1873-1875)cgT>cgA	p.R625R	ITCH_ENST00000535650.1_Silent_p.R515R|ITCH_ENST00000262650.6_Silent_p.R666R|ITCH_ENST00000483727.1_3'UTR	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	666	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						TCTATAAGCGTATCTTGAACA	0.338000													48	119					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161838	41161838	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:41161838C>A	ENST00000263413.3	-	10	1679	c.1415G>T	c.(1414-1416)tGg>tTg	p.W472L	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Missense_Mutation_p.W472L	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	472	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGATTCTAACCACTCAGAAAA	0.428000													5	111					1.024e-07	1.1264e-07	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72821618	72821618	+	Silent	SNP	A	A	G	rs112443847		TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr16:72821618A>G	ENST00000268489.5	-	10	11229	c.10557T>C	c.(10555-10557)ggT>ggC	p.G3519G	AC004943.1_ENST00000584072.1_RNA|ZFHX3_ENST00000397992.5_Silent_p.G2605G	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3519	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G3519G(3)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccaccgccgccgc	0.716000													3	19					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6711128	6711128	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr12:6711128T>C	ENST00000309577.6	-	4	599	c.436A>G	c.(436-438)Aag>Gag	p.K146E	CHD4_ENST00000544040.1_Missense_Mutation_p.K139E|CHD4_ENST00000357008.2_Missense_Mutation_p.K146E|CHD4_ENST00000544484.1_Missense_Mutation_p.K143E			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	146					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CCAGGCACCTTTGAATCATCA	0.433000													9	31					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14268133	14268133	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr19:14268133T>C	ENST00000340736.6	-	15	2987	c.2690A>G	c.(2689-2691)aAg>aGg	p.K897R	CTB-55O6.12_ENST00000588387.1_RNA|CTB-55O6.12_ENST00000592086.1_RNA|LPHN1_ENST00000361434.3_Missense_Mutation_p.K892R	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	897					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCACAGGTTCTTGTGGATGGT	0.597000													30	92					0	0	1	0	0
FLT3LG	0	broad.mit.edu	37	19	49979782	49979782	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr19:49979782G>A	ENST00000595510.1	+	4	356	c.55G>A	c.(55-57)Gtg>Atg	p.V19M	FLT3LG_ENST00000594009.1_Missense_Mutation_p.V101M|FLT3LG_ENST00000600429.1_Missense_Mutation_p.V101M|FLT3LG_ENST00000597551.1_Missense_Mutation_p.V101M|CTD-3148I10.9_ENST00000599536.1_Intron|FLT3LG_ENST00000595815.1_3'UTR|FLT3LG_ENST00000204637.2_Missense_Mutation_p.V19M|FLT3LG_ENST00000596435.1_Missense_Mutation_p.V101M|FLT3LG_ENST00000344019.3_Missense_Mutation_p.V101M			P49771	FLT3L_HUMAN	fms-related tyrosine kinase 3 ligand	101					positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity			large_intestine(2)|lung(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	10		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		GCTGGAGCGCGTGAACACGGA	0.587000											OREG0025623	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	49					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519322	113519322	+	Missense_Mutation	SNP	C	C	T	rs144397367		TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr7:113519322C>T	ENST00000284601.3	-	4	1893	c.1825G>A	c.(1825-1827)Gct>Act	p.A609T		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	609					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CCTCCTAAAGCGCTGCCTTCA	0.403000													15	131					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34517406	34517406	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr9:34517406G>A	ENST00000242317.4	+	19	2113	c.1942G>A	c.(1942-1944)Gat>Aat	p.D648N		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	648					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		CATTGTGGGCGATGACCGTGG	0.532000									Kartagener syndrome				24	42					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069307	57069307	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr11:57069307G>A	ENST00000532437.1	-	8	5256	c.4945C>T	c.(4945-4947)Cct>Tct	p.P1649S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P1649S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1649	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTCAGGCCAGGAAAGAGGTTG	0.557000													15	34					0	0	1	0	0
TRIM39-RPP21	0	broad.mit.edu	37	6	30314252	30314252	+	Silent	SNP	C	C	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr6:30314252C>T	ENST00000513556.1	+	9	1068	c.1068C>T	c.(1066-1068)tgC>tgT	p.C356C	RPP21_ENST00000466327.1_3'UTR|RPP21_ENST00000428040.2_Silent_p.C118C|RPP21_ENST00000442966.2_Silent_p.C95C|RPP21_ENST00000436442.2_Silent_p.C95C|RPP21_ENST00000433076.2_Silent_p.C103C	NM_001199119.1	NP_001186048.1	A6ZJ12	A6ZJ12_HUMAN		356						intracellular	zinc ion binding										GCCTAACATGCCAGCGCAGCC	0.582000													3	51					0	0	1	0	0
CCR7	1236	broad.mit.edu	37	17	38711358	38711358	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr17:38711358C>A	ENST00000246657.2	-	3	835	c.773G>T	c.(772-774)cGc>cTc	p.R258L	CCR7_ENST00000579344.1_Missense_Mutation_p.R252L	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	258					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				GGCCTTGTTGCGCTCAAAGTT	0.582000													4	62					1	1	1	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43821152	43821152	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr12:43821152G>T	ENST00000389420.3	-	27	4065	c.4066C>A	c.(4066-4068)Cca>Aca	p.P1356T	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.P474T|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.P1356T	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1356	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CAAGGCCCTGGACCACATTGC	0.448000													12	41					7.03913e-09	7.94158e-09	1	1	0
THOC5	8563	broad.mit.edu	37	22	29924168	29924168	+	Splice_Site	SNP	T	T	C			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr22:29924168T>C	ENST00000490103.1	-	11	1089		c.e11-2		CTA-256D12.11_ENST00000411969.1_RNA|THOC5_ENST00000397871.1_Splice_Site|THOC5_ENST00000397872.1_Splice_Site|THOC5_ENST00000397873.2_Splice_Site	NM_003678.4	NP_003669.4	Q13769	THOC5_HUMAN	THO complex 5						intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCGGCGCTTCTGGACAAAGGA	0.572000													23	44					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118969534	118969534	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr10:118969534C>A	ENST00000334549.1	+	3	879	c.879C>A	c.(877-879)taC>taA	p.Y293*		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	293						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		TTTTTGCCTACATTTCCTGTG	0.498000													9	152					5.4927e-09	6.35997e-09	1	1	0
PPOX	5498	broad.mit.edu	37	1	161140216	161140216	+	Silent	SNP	G	G	A			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr1:161140216G>A	ENST00000367999.4	+	10	1271	c.1005G>A	c.(1003-1005)gtG>gtA	p.V335V	PPOX_ENST00000495483.1_3'UTR|PPOX_ENST00000432542.2_Silent_p.V80V|PPOX_ENST00000352210.5_Silent_p.V335V|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000535223.1_Intron	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	335					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GACATTTGGTGCCATCTTCAG	0.547000													23	42					0	0	1	0	0
POU5F2	134187	broad.mit.edu	37	5	93077212	93077212	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:93077212C>T	ENST00000510627.4	-	1	131	c.58G>A	c.(58-60)Ggc>Agc	p.G20S	FAM172A_ENST00000509739.1_Intron|FAM172A_ENST00000395965.3_Intron|FAM172A_ENST00000509163.1_Intron|FAM172A_ENST00000505869.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	20						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		CCTCTGGGGCCGCCCCCACCA	0.687000													14	9					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488218	24488219	+	Frame_Shift_Ins	INS	-	-	T			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr5:24488218_24488219insT	ENST00000264463.4	-	12	2427_2428	c.1920_1921insA	c.(1918-1923)aaagccfs	p.A641fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	641					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATCAGAGGCTCTTTTTTTCGCT	0.406										HNSCC(23;0.051)			17	116	---	---	---	---					
FOXA1	3169	broad.mit.edu	37	14	38061202	38061208	+	Frame_Shift_Del	DEL	GGCGGCG	GGCGGCG	-			TCGA-J9-A8CP-01A-11D-A34U-08	TCGA-J9-A8CP-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f6fc7ff0-f510-4b66-b422-4e9a5c0552d6	38604397-3014-4f48-9b92-dbdb45f28a33	g.chr14:38061202_38061208delGGCGGCG	ENST00000250448.2	-	2	842_848	c.781_787delCGCCGCC	c.(781-789)agfs	p.RRQ261fs	FOXA1_ENST00000540786.1_Frame_Shift_Del_p.RRQ228fs|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	261					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		AAGCGCTTCTGGCGGCGCAAGTAGCAG	0.710													8	27	---	---	---	---					
