Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XIRP2	129446	broad.mit.edu	37	2	168099892	168099892	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr2:168099892G>A	ENST00000409195.1	+	9	2079	c.1990G>A	c.(1990-1992)Gac>Aac	p.D664N	XIRP2_ENST00000295237.9_Missense_Mutation_p.D664N|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D442N|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	489					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGGCCATTGGACTCAATGAA	0.428000													37	53					0	0	1	0	0
FAM63A	55793	broad.mit.edu	37	1	150974945	150974945	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr1:150974945C>T	ENST00000361936.5	-	3	1103	c.149G>A	c.(148-150)cGg>cAg	p.R50Q	FAM63A_ENST00000312210.5_Intron|FAM63A_ENST00000493834.2_Intron|FAM63A_ENST00000361738.6_Missense_Mutation_p.R98Q|FAM63A_ENST00000470877.1_Intron	NM_018379.4	NP_060849.2	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	50							protein binding	p.R50Q(1)		breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGCTGGCTCCCGTTCTCTAGC	0.592000													51	56					0	0	1	0	0
C4orf46	201725	broad.mit.edu	37	4	159592815	159592815	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr4:159592815C>A	ENST00000379205.4	-	1	383	c.139G>T	c.(139-141)Ggc>Tgc	p.G47C	C4orf46_ENST00000508836.1_Intron|C4orf46_ENST00000508457.1_Missense_Mutation_p.G47C	NM_001008393.2	NP_001008394.1	Q504U0	CD046_HUMAN	chromosome 4 open reading frame 46	47										kidney(1)|lung(3)|skin(1)	5						ACCGTTGGGCCGCTGCTCCTG	0.687000													3	22					1	1	1	1	0
CSNK2A3	283106	broad.mit.edu	37	11	11373726	11373726	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:11373726G>A	ENST00000528848.2	-	1	1178	c.941C>T	c.(940-942)aCt>aTt	p.T314I	GALNT18_ENST00000227756.4_Intron	NM_001256686.1	NP_001243615.1			casein kinase 2, alpha 3 polypeptide																		CTCTCTTGCAGTAAGCCGTGA	0.547000													4	77					0	0	1	0	0
POLR2E	5434	broad.mit.edu	37	19	1089510	1089510	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr19:1089510T>C	ENST00000215587.7	-	7	891	c.608A>G	c.(607-609)tAc>tGc	p.Y203C	POLR2E_ENST00000585838.1_5'UTR|POLR2E_ENST00000586746.1_Missense_Mutation_p.Y203C			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	203					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTAGGTGATGTACCTGCCAGC	0.637000													16	26					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111564682	111564682	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr3:111564682C>A	ENST00000393934.3	+	4	1451	c.881C>A	c.(880-882)cCa>cAa	p.P294Q	PLCXD2_ENST00000477665.1_3'UTR|PHLDB2_ENST00000393923.3_5'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	0					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						GCACTGATCCCAGTTTATCCT	0.463000													48	68					1.11015e-26	1.21588e-26	1	1	0
SPOP	8405	broad.mit.edu	37	17	47696644	47696644	+	Missense_Mutation	SNP	A	A	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr17:47696644A>C	ENST00000393331.3	-	6	774	c.304T>G	c.(304-306)Ttc>Gtc	p.F102V	SPOP_ENST00000504102.1_Missense_Mutation_p.F102V|SPOP_ENST00000503676.1_Missense_Mutation_p.F102V|SPOP_ENST00000393328.2_Missense_Mutation_p.F102V|SPOP_ENST00000347630.2_Missense_Mutation_p.F102V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	102	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						GAGAATTTGAATTTTGCCCGA	0.408000										Prostate(2;0.17)			40	66					0	0	1	0	0
KLF7	8609	broad.mit.edu	37	2	207988820	207988820	+	Silent	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr2:207988820C>T	ENST00000309446.6	-	2	787	c.411G>A	c.(409-411)acG>acA	p.T137T	KLF7_ENST00000467833.1_Intron|KLF7_ENST00000458272.1_Intron|KLF7_ENST00000421199.1_Silent_p.T104T|KLF7_ENST00000412414.2_Silent_p.T109T|KLF7_ENST00000423015.1_Silent_p.T137T	NM_003709.3	NP_003700.1	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	137					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(3)|liver(1)|lung(4)|skin(1)	11				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		ACGATGGGGGCGTTAATGAGG	0.587000													19	35					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	46000248	46000248	+	Missense_Mutation	SNP	T	T	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr21:46000248T>A	ENST00000400372.1	-	1	233	c.208A>T	c.(208-210)Acg>Tcg	p.T70S	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	70	22 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						cacgagggcgtgcaggAGCTG	0.706000													45	40					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120007806	120007806	+	Nonsense_Mutation	SNP	C	C	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chrX:120007806C>A	ENST00000371311.3	-	2	1098	c.844G>T	c.(844-846)Gaa>Taa	p.E282*		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	282										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TTTTCTTGTTCTTTCTCTTCC	0.458000													321	30					6.69537e-141	7.69967e-141	1	1	0
ARID2	196528	broad.mit.edu	37	12	46230731	46230731	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr12:46230731T>C	ENST00000334344.6	+	8	1152	c.980T>C	c.(979-981)tTa>tCa	p.L327S	ARID2_ENST00000422737.1_Missense_Mutation_p.L178S|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	327					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTATTTCTTTAAGGCAATTA	0.363000			"""N, S, F"""		hepatocellular carcinoma								26	53					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564577	176564577	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr1:176564577C>T	ENST00000367662.3	+	3	3001	c.1837C>T	c.(1837-1839)Cgc>Tgc	p.R613C	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R613C	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	613	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGGTGACTGCCGCCTGCAGGG	0.587000													27	30					0	0	1	0	0
C2orf62	375307	broad.mit.edu	37	2	219232553	219232553	+	Missense_Mutation	SNP	G	G	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr2:219232553G>C	ENST00000289388.3	+	10	1059	c.1030G>C	c.(1030-1032)Gtc>Ctc	p.V344L	AC021016.6_ENST00000441749.1_RNA|C2orf62_ENST00000481940.1_3'UTR	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	344										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGGACGTGGTCACCTTCGC	0.701000													7	25					0	0	1	0	0
RPL12	6136	broad.mit.edu	37	9	130210646	130210646	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr9:130210646G>A	ENST00000361436.5	-	5	436	c.349C>T	c.(349-351)Cgg>Tgg	p.R117W	RPL12_ENST00000497322.1_5'UTR|RPL12_ENST00000536368.1_Missense_Mutation_p.R84W	NM_000976.3	NP_000967.1	P30050	RL12_HUMAN	ribosomal protein L12	117					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)	4						GATCGGTGCCGCATCTGTCGA	0.423000													5	238					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39627771	39627771	+	Silent	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr22:39627771G>A	ENST00000331163.6	-	4	1099	c.312C>T	c.(310-312)ttC>ttT	p.F104F	PDGFB_ENST00000381551.4_Silent_p.F89F	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	104					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	GGGAGATCTCGAACACCTCGG	0.647000			T	COL1A1	DFSP								14	8					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981644	70981644	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr8:70981644G>A	ENST00000276594.2	-	2	653	c.452C>T	c.(451-453)cCa>cTa	p.P151L		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AGGGGGCGGTGGAATTAAAGT	0.577000													46	32					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323309	31323309	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr18:31323309G>A	ENST00000269197.5	+	12	3497	c.3497G>A	c.(3496-3498)aGa>aAa	p.R1166K		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CCAAACTGTAGATCTCCTAGC	0.463000													18	24					0	0	1	0	0
DPY19L2P1	0	broad.mit.edu	37	7	35131480	35131480	+	RNA	SNP	A	A	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr7:35131480A>T	ENST00000436258.1	-	0	1889																											ATCTTCGTAAAGTGGATGATT	0.423000													4	52					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													5	56					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5010966	5010966	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:5010966G>A	ENST00000380390.1	+	3	404	c.188G>A	c.(187-189)cGg>cAg	p.R63Q	MMP26_ENST00000477339.1_3'UTR|MMP26_ENST00000300762.1_Missense_Mutation_p.R63Q			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	63					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R63P(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAATTCCATCGGAATGGGACA	0.527000													14	11					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20864418	20864418	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr12:20864418A>G	ENST00000381552.1	+	5	871	c.503A>G	c.(502-504)gAa>gGa	p.E168G	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.E168G|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.E50G|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.E168G|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.E168G			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	168					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TCAGTTATGGAAAAATCAAAA	0.343000													52	39					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186380216	186380216	+	Nonsense_Mutation	SNP	T	T	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr4:186380216T>A	ENST00000307588.3	-	6	1600	c.1525A>T	c.(1525-1527)Aaa>Taa	p.K509*	CCDC110_ENST00000510617.1_Nonsense_Mutation_p.K509*|CCDC110_ENST00000393540.3_Nonsense_Mutation_p.K472*	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	509						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		attatttttttaaattCTTTA	0.279000													21	31					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26822387	26822387	+	Missense_Mutation	SNP	G	G	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr10:26822387G>T	ENST00000376236.4	+	9	1288	c.833G>T	c.(832-834)aGa>aTa	p.R278I		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	278					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TTGGATAACAGAGGAAAAAAA	0.348000													16	21					6.94344e-10	7.42787e-10	1	1	0
TPTE	7179	broad.mit.edu	37	21	10951330	10951330	+	Missense_Mutation	SNP	A	A	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr21:10951330A>C	ENST00000298232.7	-	9	695	c.328T>G	c.(328-330)Tct>Gct	p.S110A	TPTE_ENST00000361285.4_Missense_Mutation_p.S128A|TPTE_ENST00000342420.5_Missense_Mutation_p.S90A|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	128					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAGAAATAGAACGATACTCC	0.343000													37	114					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49048337	49048337	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr15:49048337T>G	ENST00000380950.2	-	20	3295	c.3108A>C	c.(3106-3108)caA>caC	p.Q1036H	CEP152_ENST00000399334.3_Missense_Mutation_p.Q1036H|CEP152_ENST00000325747.5_Missense_Mutation_p.Q943H	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1036					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		AGATTTCCAGTTGGATCCGCT	0.428000													51	59					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57590912	57590912	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr12:57590912C>T	ENST00000243077.3	+	56	9506	c.9040C>T	c.(9040-9042)Cgc>Tgc	p.R3014C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3014	EGF-like 12; calcium-binding (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTATGCACCCCGCGGCGGCGA	0.637000													46	50					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277395	94277395	+	Silent	SNP	G	G	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:94277395G>T	ENST00000358752.2	+	1	379	c.96G>T	c.(94-96)tcG>tcT	p.S32S		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	32					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GGGCCTGGTCGGGCCGGCTGG	0.786000													12	11					1.08611e-07	1.13548e-07	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													6	80					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65561891	65561891	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr2:65561891T>C	ENST00000356388.4	-	3	410	c.221A>G	c.(220-222)tAt>tGt	p.Y74C	SPRED2_ENST00000443619.2_Missense_Mutation_p.Y71C|SPRED2_ENST00000474228.1_5'UTR	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	74	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						CTTTCTTACATAGCATTCCAA	0.433000													57	46					0	0	1	0	0
IRAK3	0	broad.mit.edu	37	12	66597520	66597520	+	Missense_Mutation	SNP	G	G	C			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr12:66597520G>C	ENST00000261233.4	+	2	584	c.163G>C	c.(163-165)Gtt>Ctt	p.V55L	IRAK3_ENST00000457197.2_Intron	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	55	Death.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		CTGGCTGGATGTTCGTCATAT	0.368000													20	27					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427885	3427885	+	RNA	SNP	A	A	G			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:3427885A>G	ENST00000529482.1	+	0	1002																											AGCTTCACAGATCCACCGCTG	0.587000													3	16					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9522776	9522776	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:9522776C>T	ENST00000396602.2	+	11	1225	c.1106C>T	c.(1105-1107)gCc>gTc	p.A369V	ZNF143_ENST00000396597.3_Missense_Mutation_p.A338V|ZNF143_ENST00000396604.1_Missense_Mutation_p.A368V|ZNF143_ENST00000530463.1_Missense_Mutation_p.A368V|ZNF143_ENST00000299606.2_Missense_Mutation_p.A341V	NM_003442.5	NP_003433.3	P52747	ZN143_HUMAN	zinc finger protein 143	369					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	13				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		AGGGCATTTGCCAGTGCAACA	0.418000													4	139					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72293527	72293527	+	Silent	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:72293527G>A	ENST00000334456.5	-	21	2057	c.1812C>T	c.(1810-1812)acC>acT	p.T604T	PDE2A_ENST00000540345.1_Silent_p.T595T|PDE2A_ENST00000444035.2_Silent_p.T595T|PDE2A_ENST00000418754.2_Silent_p.T489T|PDE2A_ENST00000376450.3_Silent_p.T348T|PDE2A_ENST00000544570.1_Silent_p.T597T	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	604					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GAGGGGTATAGGTGAAACTTG	0.527000													21	31					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144881611	144881611	+	Silent	SNP	C	C	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr1:144881611C>T	ENST00000369359.4	-	28	4034	c.3996G>A	c.(3994-3996)caG>caA	p.Q1332Q	PDE4DIP_ENST00000530740.1_Silent_p.Q1332Q|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Silent_p.Q1195Q|PDE4DIP_ENST00000369356.4_Silent_p.Q1195Q|PDE4DIP_ENST00000313382.9_Silent_p.Q1151Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1195					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GAGGCTGGGACTGGTTATCCA	0.582000			T	PDGFRB	MPD								15	66					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448900	155448900	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr1:155448900C>A	ENST00000368346.3	-	3	4400	c.3761G>T	c.(3760-3762)cGc>cTc	p.R1254L	ASH1L_ENST00000392403.3_Missense_Mutation_p.R1254L			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1254					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ATGATTCCTGCGCTTACATTT	0.393000													67	105					2.23399e-28	2.50643e-28	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100026096	100026096	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr8:100026096A>G	ENST00000395996.1	+	2	191	c.80A>G	c.(79-81)cAg>cGg	p.Q27R	VPS13B_ENST00000355155.1_Missense_Mutation_p.Q27R|VPS13B_ENST00000358544.2_Missense_Mutation_p.Q27R|VPS13B_ENST00000441350.2_Missense_Mutation_p.Q27R|VPS13B_ENST00000357162.2_Missense_Mutation_p.Q27R			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	27					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCGGATCTACAGCTTTCACTA	0.423000													134	104					0	0	1	0	0
ZNF366	0	broad.mit.edu	37	5	71752404	71752404	+	Missense_Mutation	SNP	A	A	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr5:71752404A>T	ENST00000318442.5	-	3	1841	c.1351T>A	c.(1351-1353)Tgt>Agt	p.C451S		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	451					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CAAATCCCACACTTATGCTCC	0.512000													31	67					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587793	55587793	+	Missense_Mutation	SNP	C	C	T	rs143615376	by1000genomes	TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr11:55587793C>T	ENST00000333976.4	+	1	708	c.688C>T	c.(688-690)Cgt>Tgt	p.R230C		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CCTCAAGATGCGTTCAGTCAG	0.502000													37	43					0	0	1	0	0
GPR132	29933	broad.mit.edu	37	14	105518072	105518072	+	Silent	SNP	G	G	A			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr14:105518072G>A	ENST00000329797.3	-	4	1313	c.402C>T	c.(400-402)tgC>tgT	p.C134C	GPR132_ENST00000392585.2_Silent_p.C125C|GPR132_ENST00000546679.1_5'UTR|GPR132_ENST00000539291.2_Silent_p.C134C	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	134					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		AGGAGATGCAGCACAGGAAGA	0.632000													4	128					0	0	1	0	0
AC004381.6	0	broad.mit.edu	37	16	20824563	20824563	+	Missense_Mutation	SNP	G	G	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr16:20824563G>T	ENST00000261377.6	+	3	399	c.190G>T	c.(190-192)Gac>Tac	p.D64Y	AC004381.6_ENST00000567297.1_3'UTR|AC004381.6_ENST00000564274.1_Missense_Mutation_p.D64Y|AC004381.6_ENST00000348433.6_Missense_Mutation_p.D64Y|ERI2_ENST00000564349.1_Intron	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					AGTAACCCATGACCAGCTGTG	0.413000													3	56					6.4e-05	6.54222e-05	1	1	0
AC226119.5	0	broad.mit.edu	37	4	3951121	3951122	+	RNA	INS	-	-	TGTC	rs35568143		TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr4:3951121_3951122insTGTC	ENST00000281228.8	-	0	344				FAM86EP_ENST00000313946.8_RNA																							cgttttcACTTTGTGCAGGAAG	0.515													6	4	---	---	---	---					
NOX3	50508	broad.mit.edu	37	6	155761204	155761204	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr6:155761204delA	ENST00000159060.2	-	6	656	c.554delT	c.(553-555)gcfs	p.V185fs		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	185	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CATGATCAAGACTAAAGCCAG	0.438													21	36	---	---	---	---					
FOXA1	3169	broad.mit.edu	37	14	38061223	38061228	+	In_Frame_Del	DEL	TCTCGA	TCTCGA	-			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr14:38061223_38061228delTCTCGA	ENST00000250448.2	-	2	822_827	c.761_766delTCGAGA	c.(760-768)tac>t	p.FEN254del	FOXA1_ENST00000545425.2_5'UTR|FOXA1_ENST00000540786.1_In_Frame_Del_p.FEN221del	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	254					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TAGCAGCCGTTCTCGAACATGTTGCC	0.689													14	17	---	---	---	---					
HERC2P9	0	broad.mit.edu	37	15	28900331	28900331	+	RNA	DEL	A	A	-			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr15:28900331delA	ENST00000528584.1	+	0	14					NR_036443.1																						actctgtctcaaaaaaaaaaa	0.413													4	6	---	---	---	---					
NCOR1	9611	broad.mit.edu	37	17	16042456	16042456	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr17:16042456delC	ENST00000268712.3	-	12	1475	c.1218delG	c.(1216-1218)atfs	p.M407fs	NCOR1_ENST00000395848.1_Frame_Shift_Del_p.M298fs|NCOR1_ENST00000395851.1_Frame_Shift_Del_p.M407fs	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	407					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CATCAAACATCATAGGTGGAA	0.338													27	62	---	---	---	---					
C19orf33	64073	broad.mit.edu	37	19	38795558	38795566	+	In_Frame_Del	DEL	AGAAGGGCA	AGAAGGGCA	-	rs149188740	byFrequency	TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr19:38795558_38795566delAGAAGGGCA	ENST00000301246.5	+	4	376_384	c.275_283delAGAAGGGCA	c.(274-285)gag>g	p.EKGK92del	C19orf33_ENST00000588605.1_3'UTR	NM_033520.1	NP_277055.1	Q9GZP8	IMUP_HUMAN	chromosome 19 open reading frame 33	92						nucleus						all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			aagaagaaggagaagggcaagaaggagaa	0.608													10	21	---	---	---	---					
ERF	2077	broad.mit.edu	37	19	42753613	42753614	+	Frame_Shift_Ins	INS	-	-	T			TCGA-KC-A7F5-01A-11D-A33T-08	TCGA-KC-A7F5-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	18346a75-5c68-44ad-94d2-2c935cb2b87a	e883ecaa-298d-48b8-929a-0ce5fb7b476b	g.chr19:42753613_42753614insT	ENST00000222329.4	-	4	807_808	c.650_651insA	c.(649-651)tcgfs	p.S217fs	AC006486.9_ENST00000594664.1_Intron|ERF_ENST00000440177.2_Frame_Shift_Ins_p.S142fs	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	217					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GGGGCCCTCGGAAGGCACCCAG	0.693													6	10	---	---	---	---					
