Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CIT	11113	broad.mit.edu	37	12	120214536	120214536	+	Silent	SNP	A	A	C			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr12:120214536A>C	ENST00000392521.2	-	14	1831	c.1776T>G	c.(1774-1776)tcT>tcG	p.S592S	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Silent_p.S592S	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	592					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAGCAAGCCGAGACTCTCTCA	0.468000													7	73					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89668954	89668954	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr4:89668954T>C	ENST00000264344.5	-	18	2417	c.2210A>G	c.(2209-2211)cAg>cGg	p.Q737R	FAM13A_ENST00000511976.1_Missense_Mutation_p.Q323R|FAM13A_ENST00000503556.1_Missense_Mutation_p.Q397R|FAM13A_ENST00000395002.2_Missense_Mutation_p.Q411R|FAM13A_ENST00000508369.1_Missense_Mutation_p.Q411R|FAM13A_ENST00000513837.1_Missense_Mutation_p.Q383R	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	737					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GTTGCTTCGCTGCCGCATCCT	0.393000													17	69					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545907	82545907	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr7:82545907G>A	ENST00000423517.2	-	7	11732	c.11395C>T	c.(11395-11397)Cga>Tga	p.R3799*	PCLO_ENST00000333891.8_Nonsense_Mutation_p.R3799*|PCLO_ENST00000437081.1_Nonsense_Mutation_p.R519*	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3730	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCCAGGTATCGTAGCTTAGCA	0.448000													11	14					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55866955	55866955	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr16:55866955C>A	ENST00000422046.2	-	1	294	c.13G>T	c.(13-15)Gcc>Tcc	p.A5S	CES1_ENST00000361503.4_Missense_Mutation_p.A5S|CES1_ENST00000360526.3_Missense_Mutation_p.A5S			P23141	EST1_HUMAN	carboxylesterase 1	5				RAFI -> PALV (in Ref. 3; BAA04650, 8; BAC87749/BAC87751, 9; BAF83312/BAF84898 and 11; AAH12418).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	AGGATAAAGGCACGGAGCCAC	0.602000													5	11					0.000602214	0.000619927	1	1	0
ACVR1C	130399	broad.mit.edu	37	2	158395160	158395160	+	Silent	SNP	C	C	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr2:158395160C>A	ENST00000243349.7	-	8	1641	c.1281G>T	c.(1279-1281)tcG>tcT	p.S427S	ACVR1C_ENST00000409680.3_Silent_p.S377S|ACVR1C_ENST00000348328.5_Silent_p.S270S|ACVR1C_ENST00000335450.7_Silent_p.S347S	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	427	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity	p.S427S(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TTTCCTCTATCGAGGGATCTG	0.363000													10	65					6.40141e-05	7.00154e-05	1	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87451282	87451282	+	Silent	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr16:87451282C>T	ENST00000268616.4	-	8	973	c.756G>A	c.(754-756)ccG>ccA	p.P252P		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	252					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGGAGCCGGCCGGGTGCTGCC	0.697000													4	23					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75029417	75029417	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr10:75029417G>C	ENST00000401621.2	-	26	3312	c.3192C>G	c.(3190-3192)aaC>aaG	p.N1064K	TTC18_ENST00000394865.1_Missense_Mutation_p.N1034K|TTC18_ENST00000493787.1_Intron|DNAJC9-AS1_ENST00000440197.2_RNA|TTC18_ENST00000355577.3_Missense_Mutation_p.N533K|TTC18_ENST00000340329.3_Missense_Mutation_p.N304K|TTC18_ENST00000310715.3_Missense_Mutation_p.N1064K			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	1064							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CAGCATTGTAGTTGTTCAATG	0.463000													5	37					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143565394	143565394	+	Silent	SNP	G	G	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr8:143565394G>A	ENST00000517894.1	+	12	3081	c.2187G>A	c.(2185-2187)gaG>gaA	p.E729E	BAI1_ENST00000323289.5_Silent_p.E729E			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	729					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACAAGTGGGAGGAGGCCCAGC	0.622000													5	95					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58752108	58752108	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr16:58752108C>T	ENST00000245206.5	-	6	822	c.694G>A	c.(694-696)Gtg>Atg	p.V232M	GOT2_ENST00000564400.1_5'UTR|GOT2_ENST00000434819.2_Missense_Mutation_p.V189M	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	232					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ACCTTCACCACTGTTGCTATT	0.498000													9	55					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1499970	1499970	+	Silent	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chrX:1499970C>T	ENST00000331035.4	+	11	1384	c.1035C>T	c.(1033-1035)atC>atT	p.I345I	IL3RA_ENST00000381469.2_Silent_p.I267I	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	345						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AAGACCCCATCGGTGACAGCT	0.567000													89	159					0	0	1	0	0
KLHL15	80311	broad.mit.edu	37	X	24007025	24007025	+	Silent	SNP	A	A	G			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chrX:24007025A>G	ENST00000328046.8	-	4	1083	c.828T>C	c.(826-828)cgT>cgC	p.R276R		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	276										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						GTTTTGCAGAACGGATGCGGC	0.433000													5	86					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636849	152636849	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr1:152636849G>A	ENST00000368784.1	+	2	323	c.268G>A	c.(268-270)Gat>Aat	p.D90N		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	90	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGAGCCCCGATTGCTGTGA	0.667000													4	88					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138376590	138376590	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr3:138376590A>T	ENST00000477593.1	-	21	2957	c.2884T>A	c.(2884-2886)Tat>Aat	p.Y962N	PIK3CB_ENST00000544716.1_Missense_Mutation_p.Y413N|PIK3CB_ENST00000289153.2_Missense_Mutation_p.Y962N			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	962	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						ATGAAATCATAGGTAAGAATA	0.383000													4	37					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52001535	52001535	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr19:52001535G>T	ENST00000291707.3	-	5	1197	c.1142C>A	c.(1141-1143)aCa>aAa	p.T381K	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.T263K	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	381	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTCAAGGTTGTGGATGCTGT	0.557000													5	1					0.000602214	0.000619927	1	1	0
MARCH1	55016	broad.mit.edu	37	4	164534558	164534558	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr4:164534558G>C	ENST00000339875.5	-	1	128	c.99C>G	c.(97-99)aaC>aaG	p.N33K	MARCH1_ENST00000503008.1_Intron|MARCH1_ENST00000274056.7_Intron|MARCH1_ENST00000514618.1_Intron	NM_017923.3	NP_060393.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	50	Responsible for low stability (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGAGAAACAAGTTAGATAATT	0.438000													17	36					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17188685	17188685	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr8:17188685C>T	ENST00000180173.5	-	7	873	c.839G>A	c.(838-840)aGg>aAg	p.R280K	MTMR7_ENST00000521857.1_Missense_Mutation_p.R280K	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	280	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		CAGACTGTTCCTCATGACATG	0.383000													7	45					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766078	14766078	+	Silent	SNP	G	G	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr12:14766078G>A	ENST00000261170.3	-	27	3331	c.3195C>T	c.(3193-3195)acC>acT	p.T1065T	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1065					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.T1065T(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CCTTGTCTGTGGTATTCAGCT	0.438000													58	98					0	0	1	0	0
GGT3P	0	broad.mit.edu	37	22	18778612	18778612	+	RNA	SNP	C	C	T	rs1055042	by1000genomes	TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr22:18778612C>T	ENST00000412448.1	-	0	793																											GCGGCCACGGCAGCCCTGGTG	0.637000													4	13					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28202759	28202759	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr15:28202759C>T	ENST00000354638.3	-	16	1914	c.1759G>A	c.(1759-1761)Gcc>Acc	p.A587T	OCA2_ENST00000353809.5_Missense_Mutation_p.A563T|OCA2_ENST00000382996.2_Missense_Mutation_p.A587T	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	587					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGCCTCCGGGCGAGCAGGTGC	0.652000									Oculocutaneous Albinism				16	16					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159466	39159466	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr6:39159466C>T	ENST00000359534.3	-	5	1038	c.700G>A	c.(700-702)Ggg>Agg	p.G234R		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	234					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CAGGCCAGCCCCAAGTAGATC	0.577000													17	62					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092403	151092403	+	Silent	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chrX:151092403C>T	ENST00000370340.3	+	3	534	c.267C>T	c.(265-267)agC>agT	p.S89S	MAGEA4_ENST00000393921.1_Silent_p.S89S|MAGEA4_ENST00000370335.1_Silent_p.S89S|MAGEA4_ENST00000276344.2_Silent_p.S89S|MAGEA4_ENST00000393920.1_Silent_p.S89S|MAGEA4_ENST00000360243.2_Silent_p.S89S|MAGEA4_ENST00000370337.4_Silent_p.S89S			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	89							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGTTCCAGCAGCCAAGAAG	0.572000													4	32					0	0	1	0	0
HMGCL	3155	broad.mit.edu	37	1	24130988	24130988	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr1:24130988C>T	ENST00000374483.4	-	9	1374	c.703G>A	c.(703-705)Gtg>Atg	p.V235M	HMGCL_ENST00000509389.1_5'UTR|HMGCL_ENST00000436439.2_Missense_Mutation_p.V189M|HMGCL_ENST00000374490.3_Missense_Mutation_p.V260M			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	260					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		AGTCCTGCCACAGAAGAGTCC	0.537000													15	44					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215408426	215408426	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr1:215408426C>A	ENST00000444842.2	+	7	1369	c.1219C>A	c.(1219-1221)Ctg>Atg	p.L407M	KCNK2_ENST00000391895.2_Missense_Mutation_p.L403M|KCNK2_ENST00000391894.2_Missense_Mutation_p.L392M	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	407	Essential for chloroform and halothane sensitivity (By similarity).|Required for basal channel activity (By similarity).						outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	GAGTATCTATCTGAATGGTTT	0.478000													10	68					3.07112e-06	3.46739e-06	1	1	0
KCNG4	93107	broad.mit.edu	37	16	84256130	84256130	+	Missense_Mutation	SNP	G	G	A	rs140682724	byFrequency	TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr16:84256130G>A	ENST00000308251.4	-	3	1321	c.1253C>T	c.(1252-1254)aCg>aTg	p.T418M		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	418						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GTAGCCCACCGTTGTCATGGA	0.642000													4	37					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130775905	130775905	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr11:130775905C>T	ENST00000265909.4	-	7	2955	c.2386G>A	c.(2386-2388)Gac>Aac	p.D796N	SNX19_ENST00000533214.1_Missense_Mutation_p.D779N|SNX19_ENST00000545537.1_Missense_Mutation_p.D36N|SNX19_ENST00000528555.1_Missense_Mutation_p.D176N|SNX19_ENST00000533318.1_5'UTR|SNX19_ENST00000530356.1_Missense_Mutation_p.D176N|SNX19_ENST00000534726.1_Missense_Mutation_p.D36N|SNX19_ENST00000539184.1_Missense_Mutation_p.D239N	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	796					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACGCAACTGTCCACACGTCCT	0.527000													9	40					0	0	1	0	0
PRKAB1	5564	broad.mit.edu	37	12	120110138	120110138	+	Silent	SNP	G	G	A			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr12:120110138G>A	ENST00000229328.5	+	2	684	c.192G>A	c.(190-192)caG>caA	p.Q64Q	PRKAB1_ENST00000541640.1_Silent_p.Q64Q|PRKAB1_ENST00000540121.1_5'UTR	NM_006253.4	NP_006244.2	Q9Y478	AAKB1_HUMAN	protein kinase, AMP-activated, beta 1 non-catalytic subunit	64					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol				endometrium(2)|large_intestine(3)|lung(5)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	TGGCCTGGCAGCATGATCTGG	0.512000													4	121					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57140009	57140009	+	Splice_Site	SNP	G	G	C			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr17:57140009G>C	ENST00000376149.3	-	11	1304	c.494_splice	c.e11-1	p.S165_splice	TRIM37_ENST00000262294.7_Splice_Site_p.S287_splice|TRIM37_ENST00000393065.2_Splice_Site_p.S253_splice|TRIM37_ENST00000393066.3_Splice_Site_p.S287_splice			O94972	TRI37_HUMAN	tripartite motif containing 37	287						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GACGCAAAGTGCTAACGAAAA	0.383000									Mulibrey Nanism				3	19					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76212836	76212836	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr17:76212836G>T	ENST00000301633.4	+	4	513	c.382G>T	c.(382-384)Gac>Tac	p.D128Y	AC087645.1_ENST00000600484.1_Missense_Mutation_p.S254Y|BIRC5_ENST00000589892.1_3'UTR|BIRC5_ENST00000374948.2_Intron|BIRC5_ENST00000592734.1_Intron|BIRC5_ENST00000350051.3_Missense_Mutation_p.D105Y	NM_001012271.1	NP_001012271.1	O15392	BIRC5_HUMAN	baculoviral IAP repeat containing 5	105				A -> V (in Ref. 9; CAG46540).	anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			TTTGAAACTGGACAGAGAAAG	0.388000													19	40					3.8784e-16	4.5248e-16	1	1	0
AGL	178	broad.mit.edu	37	1	100380996	100380997	+	Frame_Shift_Ins	INS	-	-	A	rs28730708	byFrequency	TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr1:100380996_100380997insA	ENST00000294724.4	+	31	4691_4692	c.4213_4214insA	c.(4213-4215)aaafs	p.K1405fs	AGL_ENST00000370165.3_Frame_Shift_Ins_p.K1405fs|AGL_ENST00000361915.3_Frame_Shift_Ins_p.K1405fs|AGL_ENST00000361522.4_Frame_Shift_Ins_p.K1388fs|AGL_ENST00000370163.3_Frame_Shift_Ins_p.K1405fs|AGL_ENST00000361302.3_Frame_Shift_Ins_p.K1389fs|AGL_ENST00000370161.2_Frame_Shift_Ins_p.K1389fs	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1405					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GGAGATTGCAGAAAAAAAATTG	0.327													15	76	---	---	---	---					
CAMKMT	79823	broad.mit.edu	37	2	44599960	44599960	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr2:44599960delG	ENST00000378494.3	+	2	288	c.244delG	c.(244-246)aafs	p.E84fs	CAMKMT_ENST00000403853.3_Frame_Shift_Del_p.E84fs|CAMKMT_ENST00000407131.1_Frame_Shift_Del_p.E84fs|CAMKMT_ENST00000402247.1_Frame_Shift_Del_p.E84fs|CAMKMT_ENST00000477623.1_3'UTR	NM_024766.3	NP_079042.1	Q7Z624	CMKMT_HUMAN	calmodulin-lysine N-methyltransferase	84						cytoplasm	calmodulin-lysine N-methyltransferase activity			breast(2)|large_intestine(3)|lung(5)	10						AAGGGAAACTGAAGAGGAGGT	0.373													20	30	---	---	---	---					
BAZ2B	29994	broad.mit.edu	37	2	160285752	160285754	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr2:160285752_160285754delTCT	ENST00000392783.2	-	11	2707_2709	c.2212_2214delAGA	c.(2212-2214)del	p.R738del	BAZ2B_ENST00000392782.1_In_Frame_Del_p.R736del|BAZ2B_ENST00000355831.2_In_Frame_Del_p.R738del|BAZ2B_ENST00000343439.5_In_Frame_Del_p.R638del	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	738					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CATCTGTTACTCTTCTTCTTTTG	0.266													9	35	---	---	---	---					
COL11A2	1302	broad.mit.edu	37	6	33159947	33159947	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr6:33159947delG	ENST00000341947.2	-	1	298	c.71delC	c.(70-72)cafs	p.P24fs	COL11A2_ENST00000357486.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000361917.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000395194.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000374714.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000374708.4_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000374712.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000374713.1_Frame_Shift_Del_p.P24fs|COL11A2_ENST00000395197.1_Frame_Shift_Del_p.P24fs	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	24					cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGCCCAGCCTGGGGCCGCGCT	0.677													2	4	---	---	---	---					
RAB32	10981	broad.mit.edu	37	6	146865012	146865013	+	Frame_Shift_Ins	INS	-	-	G			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr6:146865012_146865013insG	ENST00000367495.3	+	1	184_185	c.5_6insG	c.(4-6)gggfs	p.G2fs		NM_006834.3	NP_006825.1	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	2					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	8		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		GCGCTCATGGCGGGCGGAGGAg	0.792													2	4	---	---	---	---					
CYP2W1	54905	broad.mit.edu	37	7	1027017	1027017	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr7:1027017delC	ENST00000340150.6	+	7	847	c.825delC	c.(823-825)ggfs	p.G275fs	CYP2W1_ENST00000308919.7_Frame_Shift_Del_p.G331fs			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	331					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCGTGCTGGGCCCTGGGCGGA	0.731													2	4	---	---	---	---					
NUTM2G	441457	broad.mit.edu	37	9	99698708	99698708	+	Splice_Site	DEL	T	T	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr9:99698708delT	ENST00000354649.3	+	4	1559	c.842_splice	c.e4-1	p.F282_splice	NUTM2G_ENST00000372322.3_Splice_Site_p.F282_splice|HIATL2_ENST00000506067.1_Intron	NM_001045477.2	NP_001038942.1			NUT family member 2G																		CACCCCCAGGTTCCTGGAGTT	0.667													2	4	---	---	---	---					
VAPA	9218	broad.mit.edu	37	18	9954142	9954143	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr18:9954142_9954143delTC	ENST00000400000.2	+	6	939_940	c.684_685delTC	c.(682-687)ctctfs	p.LP228fs	VAPA_ENST00000340541.4_Frame_Shift_Del_p.LP273fs	NM_003574.5|NM_194434.2	NP_003565.4|NP_919415.2	Q9P0L0	VAPA_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	228					cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						CCAGTCCTCTTCCTTCACTTCT	0.391													11	97	---	---	---	---					
CA11	770	broad.mit.edu	37	19	49148883	49148883	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr19:49148883delC	ENST00000084798.4	-	1	686	c.7delG	c.(7-9)ctfs	p.A5fs	SEC1P_ENST00000430145.2_RNA	NM_001217.3	NP_001208.2	O75493	CAH11_HUMAN	carbonic anhydrase XI	5						extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)	14		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		CGAGCTGCAGCCCCCATCCCC	0.711													2	4	---	---	---	---					
MCM8	84515	broad.mit.edu	37	20	5965634	5965639	+	In_Frame_Del	DEL	AGAAAG	AGAAAG	-			TCGA-KK-A8IH-01A-11D-A364-08	TCGA-KK-A8IH-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d1652a02-f1e2-4504-bc26-0bc6d272c104	9aec7505-e824-49cf-a520-b4d090863d67	g.chr20:5965634_5965639delAGAAAG	ENST00000378896.3	+	15	2318_2323	c.1941_1946delAGAAAG	c.(1939-1947)tca>tc	p.SER647del	MCM8_ENST00000378883.1_In_Frame_Del_p.SER600del|MCM8_ENST00000378886.2_In_Frame_Del_p.SER687del|MCM8_ENST00000265187.4_In_Frame_Del_p.SER631del	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	647					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						AGCCATTATCAGAAAGACTAAAGGTA	0.374													9	26	---	---	---	---					
