Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HNRNPA3	220988	broad.mit.edu	37	2	178080605	178080605	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr2:178080605A>C	ENST00000411529.2	+	3	308	c.257A>C	c.(256-258)aAg>aCg	p.K86T	HNRNPA3_ENST00000435711.1_Missense_Mutation_p.K108T|HNRNPA3_ENST00000392524.2_Missense_Mutation_p.K108T	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	108	RRM 1.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						GTGGAACCAAAGAGAGCTGTT	0.373000													9	71					0	0	1	0	0
SYDE1	85360	broad.mit.edu	37	19	15224479	15224479	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr19:15224479G>A	ENST00000600252.1	+	5	2526	c.884G>A	c.(883-885)cGc>cAc	p.R295H	SYDE1_ENST00000600440.1_Missense_Mutation_p.R571H|SYDE1_ENST00000342784.2_Missense_Mutation_p.R638H			Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	638					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|pancreas(1)|skin(1)	17						ACTCGGCCCCGCGGTCGAGGA	0.682000													19	78					0	0	1	0	0
RAD51B	5890	broad.mit.edu	37	14	68353829	68353829	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr14:68353829G>A	ENST00000487270.1	+	7	712	c.664G>A	c.(664-666)Gca>Aca	p.A222T	RAD51B_ENST00000488612.1_Missense_Mutation_p.A222T|RAD51B_ENST00000487861.1_Missense_Mutation_p.A222T|RAD51B_ENST00000471583.1_Missense_Mutation_p.A222T|RAD51B_ENST00000390683.3_Missense_Mutation_p.A222T	NM_133509.3	NP_598193.2	O15315	RA51B_HUMAN	RAD51 paralog B	222					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity		HMGA2/RAD51B(11)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11						GGAGTTTGATGCACAACTTCA	0.373000								Direct reversal of damage					12	74					0	0	1	0	0
CTSO	1519	broad.mit.edu	37	4	156860533	156860533	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr4:156860533C>T	ENST00000433477.3	-	4	611	c.542G>A	c.(541-543)tGg>tAg	p.W181*		NM_001334.2	NP_001325.1	P43234	CATO_HUMAN	cathepsin O	181					proteolysis	lysosome	cysteine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|prostate(1)	16	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CTTGTTTAACCAGTTCAAAGC	0.388000													9	82					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997475	38997475	+	Nonsense_Mutation	SNP	C	C	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr21:38997475C>A	ENST00000400482.3	-	4	1847	c.1258G>T	c.(1258-1260)Gaa>Taa	p.E420*	KCNJ6_ENST00000288309.6_Nonsense_Mutation_p.E420*	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	420					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	ACTTTGGATTCATTCTCCAGG	0.448000													23	152					6.21321e-17	6.48335e-17	1	1	0
ZNF318	24149	broad.mit.edu	37	6	43323546	43323546	+	Missense_Mutation	SNP	C	C	T	rs147691068		TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr6:43323546C>T	ENST00000361428.2	-	4	1603	c.1526G>A	c.(1525-1527)cGc>cAc	p.R509H	ZNF318_ENST00000318149.3_Missense_Mutation_p.R509H	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	509					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCTCAGAATGCGGGAAAAACC	0.488000													7	337					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25783895	25783895	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr4:25783895C>T	ENST00000399878.3	-	15	2548	c.2426G>A	c.(2425-2427)gGc>gAc	p.G809D	SEL1L3_ENST00000502949.1_Missense_Mutation_p.G656D|SEL1L3_ENST00000264868.5_Missense_Mutation_p.G774D	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	809						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						AGGGAAGATGCCATCCAAATG	0.443000													4	123					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47855502	47855502	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr20:47855502C>A	ENST00000371764.4	+	15	1806	c.1797C>A	c.(1795-1797)ttC>ttA	p.F599L	ZNFX1_ENST00000371754.4_Silent_p.R1254R|ZNFX1_ENST00000469991.1_5'UTR|DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	599	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCCTCAAATTCCGGGACAAGA	0.488000													3	47					1	1	1	1	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	29					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176927523	176927523	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr1:176927523C>A	ENST00000367654.2	-	10	1731	c.1718G>T	c.(1717-1719)tGc>tTc	p.C573F	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000361833.2_Missense_Mutation_p.C565F|ASTN1_ENST00000367657.3_Missense_Mutation_p.C565F|ASTN1_ENST00000424564.2_Missense_Mutation_p.C565F			O14525	ASTN1_HUMAN	astrotactin 1	573					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTCCGTCTTGCACTTTGCTGA	0.532000													6	28					0.00198382	0.00202603	1	1	0
PCDHB8	0	broad.mit.edu	37	5	140558697	140558697	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr5:140558697C>T	ENST00000239444.2	+	1	1327	c.1082C>T	c.(1081-1083)gCg>gTg	p.A361V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		361	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A361V(1)		NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGAGAATGCGCCTGAAACT	0.448000													5	397					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158753717	158753717	+	Missense_Mutation	SNP	T	T	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr5:158753717T>A	ENST00000231228.2	-	2	529	c.74A>T	c.(73-75)gAa>gTa	p.E25V		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	25	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTCTTCAGTTCCCATATGGC	0.502000													6	33					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572353	186572353	+	Missense_Mutation	SNP	G	G	A	rs144526209		TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr3:186572353G>A	ENST00000412955.2	+	3	736	c.595G>A	c.(595-597)Ggc>Agc	p.G199S	ADIPOQ_ENST00000444204.2_Missense_Mutation_p.G199S|ADIPOQ_ENST00000320741.2_Missense_Mutation_p.G199S|ADIPOQ-AS1_ENST00000422718.1_RNA			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	199	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		CCAGGCCTCCGGCTCTGTGCT	0.502000													18	30					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57428325	57428325	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr11:57428325G>A	ENST00000533682.1	+	3	1420	c.695G>A	c.(694-696)gGc>gAc	p.G232D	CLP1_ENST00000302731.4_Missense_Mutation_p.G168D|CLP1_ENST00000525602.1_Missense_Mutation_p.G232D|CLP1_ENST00000529430.1_Missense_Mutation_p.G243D			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	232					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						AACACCTGTGGCTGGGTCAAG	0.488000													16	92					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26506848	26506848	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr10:26506848G>A	ENST00000376261.3	+	3	717	c.214G>A	c.(214-216)Gcc>Acc	p.A72T	GAD2_ENST00000259271.3_Missense_Mutation_p.A72T	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	72					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	ccggAAGGCCGCCTGCGCCTG	0.692000													4	17					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345723	33345723	+	Silent	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr20:33345723C>T	ENST00000374796.2	-	8	3398	c.828G>A	c.(826-828)caG>caA	p.Q276Q	NCOA6_ENST00000359003.2_Silent_p.Q276Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	276	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgttgttgctgctgctgct	0.537000													3	28					0	0	1	0	0
DCTN4	51164	broad.mit.edu	37	5	150095125	150095125	+	Splice_Site	SNP	A	A	G			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr5:150095125A>G	ENST00000447998.2	-	12	1285		c.e12+1		DCTN4_ENST00000424236.1_Splice_Site|DCTN4_ENST00000446090.2_Splice_Site	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)							centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGATCACTCACTCAGGATCG	0.428000													4	30					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56700278	56700278	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr17:56700278C>T	ENST00000389934.3	-	4	464	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	TEX14_ENST00000349033.5_Missense_Mutation_p.R116Q|TEX14_ENST00000240361.8_Missense_Mutation_p.R116Q	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	116						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATCGTGGAGTCGCAGGTCACC	0.577000													12	43					0	0	1	0	0
TMEM196	256130	broad.mit.edu	37	7	19765279	19765279	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr7:19765279G>A	ENST00000405844.1	-	3	1012	c.317C>T	c.(316-318)gCc>gTc	p.A106V	TMEM196_ENST00000422233.1_Missense_Mutation_p.A38V|TMEM196_ENST00000433641.1_Missense_Mutation_p.A38V|TMEM196_ENST00000405764.3_Missense_Mutation_p.A106V|TMEM196_ENST00000493519.1_Missense_Mutation_p.A38V			Q5HYL7	TM196_HUMAN	transmembrane protein 196	112						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						AGACATGGAGGCAAGGTGCAG	0.522000													3	51					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129155027	129155027	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chrX:129155027G>C	ENST00000540052.1	+	4	3553	c.3509G>C	c.(3508-3510)gGa>gCa	p.G1170A	BCORL1_ENST00000303743.5_Missense_Mutation_p.G1170A|BCORL1_ENST00000359304.2_Missense_Mutation_p.G1170A|BCORL1_ENST00000218147.7_Missense_Mutation_p.G1170A	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1170					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						TCAGATTCAGGAAAAGAGCAC	0.587000													3	12					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1498382	1498382	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr16:1498382C>T	ENST00000382745.4	-	21	2592	c.1987G>A	c.(1987-1989)Gtg>Atg	p.V663M	CLCN7_ENST00000262318.8_Missense_Mutation_p.V639M|CLCN7_ENST00000448525.1_Missense_Mutation_p.V639M	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	663	CBS 1.					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				TGCTCCACCACGGGGAAGCCG	0.617000													6	25					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846098	18846098	+	RNA	SNP	G	G	A	rs9306211		TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr22:18846098G>A	ENST00000412938.1	+	0	3456																											ATGCCTCGGCGCTCGATCTCC	0.622000													3	20					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837393	82837393	+	Silent	SNP	T	T	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr5:82837393T>A	ENST00000265077.3	+	8	9136	c.8571T>A	c.(8569-8571)tcT>tcA	p.S2857S	VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000343200.5_Silent_p.S1870S|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2857	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCGGCTCATCTGTAATGTCCC	0.478000													3	70					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846121	18846121	+	RNA	SNP	C	C	T	rs4302302		TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr22:18846121C>T	ENST00000412938.1	+	0	3479																											CACGCACTGGCGCACGATGTA	0.617000													3	17					0	0	1	0	0
BIVM	54841	broad.mit.edu	37	13	103468831	103468831	+	Translation_Start_Site	SNP	T	T	G			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr13:103468831T>G	ENST00000448849.2	+	0	527				BIVM_ENST00000257336.1_Missense_Mutation_p.Y178D|BIVM-ERCC5_ENST00000602836.1_Missense_Mutation_p.I149R|BIVM_ENST00000419638.1_Missense_Mutation_p.Y178D	NM_001159596.1	NP_001153068.1			basic, immunoglobulin-like variable motif containing											endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|skin(2)|urinary_tract(1)	25	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAAGGGAAGATATCAGAAGGA	0.328000													9	54					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255651	85255651	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr12:85255651A>T	ENST00000266682.5	-	12	2494	c.1953T>A	c.(1951-1953)aaT>aaA	p.N651K	SLC6A15_ENST00000309283.7_Intron|SLC6A15_ENST00000552192.1_Missense_Mutation_p.N544K	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	651					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						CAGATGCTAAATTACCAGAAC	0.443000													4	137					0	0	1	0	0
MZT1	440145	broad.mit.edu	37	13	73293170	73293170	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr13:73293170G>A	ENST00000377818.3	-	2	229	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W		NM_001071775.2	NP_001065243.1	Q08AG7	MZT1_HUMAN	mitotic spindle organizing protein 1	49					gamma-tubulin complex localization	centrosome|gamma-tubulin ring complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						TCACAAAGCCGTACACAAATA	0.353000													4	226					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000439954.2_Silent_p.G100G|FRG1B_ENST00000358464.4_Silent_p.G95G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													4	56					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106937890	106937890	+	Silent	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr10:106937890C>T	ENST00000369701.3	+	14	2195	c.1968C>T	c.(1966-1968)gaC>gaT	p.D656D	SORCS3_ENST00000369699.4_Intron	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	656						integral to membrane	neuropeptide receptor activity	p.D656D(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCTTTGTTGACGGGGCTCTGG	0.473000													10	40					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8317916	8317916	+	Silent	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr9:8317916G>A	ENST00000381196.4	-	43	6240	c.5697C>T	c.(5695-5697)gcC>gcT	p.A1899A	PTPRD_ENST00000397611.3_Silent_p.A1489A|PTPRD_ENST00000360074.4_Silent_p.A1886A|PTPRD_ENST00000397617.3_Silent_p.A1492A|PTPRD_ENST00000358503.5_Silent_p.A1877A|PTPRD_ENST00000540109.1_Silent_p.A1899A|PTPRD_ENST00000537002.1_Silent_p.A1489A|PTPRD_ENST00000486161.1_Silent_p.A1492A|PTPRD_ENST00000356435.5_Silent_p.A1899A|PTPRD_ENST00000355233.5_Silent_p.A1493A|PTPRD_ENST00000397606.3_Silent_p.A1492A	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1899	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACTCTAGTGCGGCACGATAGG	0.423000										TSP Lung(15;0.13)			12	89					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27799861	27799861	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr2:27799861A>T	ENST00000408964.2	+	1	473	c.422A>T	c.(421-423)tAt>tTt	p.Y141F		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	141										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CAGCCAAAGTATCAAATCCCT	0.378000													13	62					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34102839	34102839	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr15:34102839C>T	ENST00000389232.4	+	71	10256	c.10186C>T	c.(10186-10188)Cga>Tga	p.R3396*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.R3391*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3396					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CGCAAAATCGCGATACAGCCA	0.547000													8	43					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													7	78					0	0	1	0	0
C2orf73	129852	broad.mit.edu	37	2	54570968	54570968	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr2:54570968C>T	ENST00000398634.2	+	3	388	c.346C>T	c.(346-348)Cca>Tca	p.P116S	C2orf73_ENST00000491538.1_Intron|C2orf73_ENST00000405749.1_Missense_Mutation_p.P58S	NM_001100396.1	NP_001093866.1	Q8N5S3	CB073_HUMAN	chromosome 2 open reading frame 73	116										breast(2)	2						ACTGGTTTTGCCAGTCAAACA	0.428000													3	50					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436082	56436082	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr8:56436082G>A	ENST00000327381.5	+	3	1349	c.1249G>A	c.(1249-1251)Gtc>Atc	p.V417I		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	417						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CTTCTGGATCGTCCACTGTGA	0.483000													28	87					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96990865	96990865	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr6:96990865G>A	ENST00000369278.4	+	12	1441	c.1375G>A	c.(1375-1377)Gat>Aat	p.D459N		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	459					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										TGATGATAGTGATGATGAATC	0.378000													20	47					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200613480	200613480	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr1:200613480delC	ENST00000331314.6	-	8	1975	c.1762delG	c.(1762-1764)aafs	p.E588fs	DDX59_ENST00000447706.2_Intron|DDX59_ENST00000367348.3_Intron	NM_001031725.4	NP_001026895.2	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	588						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						TTCTGTTGTTCCTTTCTCTTC	0.368													13	81	---	---	---	---					
AC019185.4	0	broad.mit.edu	37	2	209381652	209381652	+	RNA	DEL	C	C	-			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr2:209381652delC	ENST00000424628.1	+	0	103																											ATCAACAACTCTCTGCTGGTG	0.502													2	4	---	---	---	---					
MCTP1	79772	broad.mit.edu	37	5	94288922	94288922	+	Splice_Site	DEL	C	C	-			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr5:94288922delC	ENST00000515393.1	-	3	981		c.e3+1		MCTP1_ENST00000312216.8_Splice_Site|MCTP1_ENST00000505208.1_Splice_Site|MCTP1_ENST00000429576.2_Splice_Site	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AAATGGCTCACCTTTATATAC	0.363													8	50	---	---	---	---					
SEC63	11231	broad.mit.edu	37	6	108214774	108214774	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KK-A8IM-01A-11D-A364-08	TCGA-KK-A8IM-11A-11D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8a17b3d-a5f6-48e8-b161-b9b6a528c3e6	ec655621-f470-4bca-ad72-e570cd3c3a42	g.chr6:108214774delT	ENST00000369002.4	-	16	1765	c.1586delA	c.(1585-1587)agfs	p.K530fs		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	530	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding	p.K529fs*4(1)		endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TAAAGGTTTCTTTTTTTTTGA	0.368													7	132	---	---	---	---					
