Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CNGA1	1259	broad.mit.edu	37	4	47938975	47938975	+	Silent	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr4:47938975G>A	ENST00000402813.3	-	10	1885	c.1743C>T	c.(1741-1743)atC>atT	p.I581I	CNGA1_ENST00000420489.2_Silent_p.I512I|CNGA1_ENST00000514170.1_Silent_p.I512I|CNGA1_ENST00000358519.4_Silent_p.I512I|CNGA1_ENST00000544810.1_Silent_p.I512I			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	512					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TCTCTCGTCCGATATCCCCTT	0.463000													36	59					0	0	1	0	0
MIR1208	0	broad.mit.edu	37	8	129162395	129162395	+	RNA	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr8:129162395C>T	ENST00000408334.1	+	0	34					NR_031613.1																						CAGGCGGAGACGGGTCTTTCT	0.527000													17	16					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90219898	90219898	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr9:90219898G>A	ENST00000469640.2	+	3	467	c.92G>A	c.(91-93)cGt>cAt	p.R31H	DAPK1_ENST00000408954.3_Missense_Mutation_p.R31H|DAPK1_ENST00000491893.1_Missense_Mutation_p.R31H|DAPK1_ENST00000358077.5_Missense_Mutation_p.R31H|DAPK1_ENST00000472284.1_Missense_Mutation_p.R31H			P53355	DAPK1_HUMAN	death-associated protein kinase 1	31	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity	p.R31H(2)		breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						AAGAAATGCCGTGAGAAAAGC	0.502000									Chronic Lymphocytic Leukemia, Familial Clustering of				4	7					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420521	11420521	+	RNA	SNP	C	C	T	rs113884749		TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr12:11420521C>T	ENST00000381842.3	-	0	642				PRB3_ENST00000279573.6_RNA|PRB3_ENST00000440870.3_RNA|PRB3_ENST00000538488.1_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			CTTTCCCGGACGAGGTGGGGG	0.622000													4	110					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100851	168100851	+	Silent	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr2:168100851C>T	ENST00000409195.1	+	9	3038	c.2949C>T	c.(2947-2949)ttC>ttT	p.F983F	XIRP2_ENST00000409273.1_Silent_p.F761F|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.F983F|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	808					actin cytoskeleton organization	cell junction	actin binding	p.F983F(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATCTCTCTTCGAGACAACAC	0.353000													12	22					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209185	140209185	+	Silent	SNP	G	G	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr5:140209185G>T	ENST00000529310.1	+	1	1623	c.1509G>T	c.(1507-1509)gcG>gcT	p.A503A	PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.A503A|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCGCGTTGTCGAGCT	0.672000													39	51					1.59361e-14	1.68214e-14	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102303137	102303137	+	RNA	SNP	C	C	G			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr15:102303137C>G	ENST00000561463.1	+	0	11183																											CCAACCTGCACTAGCGTGGGA	0.602000													5	29					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120527915	120527915	+	Silent	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr4:120527915C>T	ENST00000354960.3	-	2	1009	c.690G>A	c.(688-690)gtG>gtA	p.V230V	PDE5A_ENST00000394439.1_Silent_p.V178V|PDE5A_ENST00000264805.5_Silent_p.V188V	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	230	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	CCACATGTCCCACAATGCCTT	0.478000													8	73					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18937330	18937330	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr16:18937330T>C	ENST00000446231.2	-	1	446	c.34A>G	c.(34-36)Agc>Ggc	p.S12G	SMG1_ENST00000567737.1_5'UTR|SMG1_ENST00000389467.3_Missense_Mutation_p.S12G			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	12	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ccgccgccgctgcTCAGCCGA	0.736000													3	6					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606150	1606150	+	Silent	SNP	G	G	A	rs148824156	byFrequency	TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr11:1606150G>A	ENST00000382171.2	-	1	363	c.330C>T	c.(328-330)ggC>ggT	p.G110G	KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	110	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCACAAGAGCCACAGCCCC	0.667000													6	32					0	0	1	0	0
TRIM31	11074	broad.mit.edu	37	6	30080303	30080303	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr6:30080303T>C	ENST00000376734.3	-	2	405	c.280A>G	c.(280-282)Aca>Gca	p.T94A	TRIM31-AS1_ENST00000440874.1_RNA|TRIM31_ENST00000540829.1_Missense_Mutation_p.T94A	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31	94						mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						CTCGGGCATGTAGCCTCTTTC	0.488000													33	42					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	26					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29686010	29686010	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr17:29686010C>T	ENST00000358273.4	+	56	8520	c.8137C>T	c.(8137-8139)Cgg>Tgg	p.R2713W	NF1_ENST00000417592.2_3'UTR|NF1_ENST00000356175.3_Missense_Mutation_p.R2692W|NF1_ENST00000444181.2_Missense_Mutation_p.R506W	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2713					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGCTTGTGGCGGTTTGCAGG	0.308000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			16	19					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128786546	128786546	+	Silent	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr11:128786546C>T	ENST00000529694.1	+	3	1556	c.1180C>T	c.(1180-1182)Ctg>Ttg	p.L394L	KCNJ5_ENST00000533599.1_Silent_p.L394L|KCNJ5_ENST00000338350.4_Silent_p.L394L	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	394					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TGAGGCAGGGCTGGATGCAGA	0.652000													5	23					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123625199	123625199	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr11:123625199A>C	ENST00000327930.2	-	1	54	c.28T>G	c.(28-30)Ttc>Gtc	p.F10V		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGCAGGATGAATTCTGTGATT	0.413000													32	41					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10397685	10397685	+	Missense_Mutation	SNP	G	G	C	rs140473978		TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr17:10397685G>C	ENST00000226207.5	-	39	5747	c.5653C>G	c.(5653-5655)Caa>Gaa	p.Q1885E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1885						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TCTTCAGCTTGTCTCTTGTAG	0.428000													26	49					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460368	107460368	+	Silent	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr2:107460368G>A	ENST00000409382.3	-	2	676	c.66C>T	c.(64-66)ctC>ctT	p.L22L	ST6GAL2_ENST00000409087.3_Silent_p.L22L|ST6GAL2_ENST00000361686.4_Silent_p.L22L	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	22					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TCAGCAAAAAGAGGAGCCCCC	0.537000													13	29					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30064255	30064255	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr20:30064255C>T	ENST00000201979.2	+	2	300	c.7C>T	c.(7-9)Ctc>Ttc	p.L3F	DEFB124_ENST00000481595.1_Intron	NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	3					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			AAAGATGACACTCAACACCGA	0.577000													3	40					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82355665	82355665	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr8:82355665C>T	ENST00000256103.2	-	4	503	c.367G>A	c.(367-369)Gtg>Atg	p.V123M	RP11-157I4.4_ENST00000524085.2_RNA|PMP2_ENST00000519260.1_3'UTR	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	123						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			GTGCACACCACGCCCTTCATT	0.313000													128	67					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158651379	158651379	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr1:158651379C>A	ENST00000368148.3	-	4	649	c.469G>T	c.(469-471)Gcc>Tcc	p.A157S	SPTA1_ENST00000368147.3_Missense_Mutation_p.A157S	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	157					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AACTTCAGGGCCCGCAGCAAC	0.527000													46	57					2.46787e-29	2.6794e-29	1	1	0
CHST13	166012	broad.mit.edu	37	3	126260911	126260911	+	Silent	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr3:126260911C>T	ENST00000319340.2	+	3	566	c.516C>T	c.(514-516)ttC>ttT	p.F172F		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	172					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CCTTCCTGTTCGTGCGGGAGC	0.706000													6	7					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303817	151303817	+	Silent	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chrX:151303817G>A	ENST00000370323.4	-	4	592	c.276C>T	c.(274-276)tcC>tcT	p.S92S	MAGEA10_ENST00000244096.3_Silent_p.S92S|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	92										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCGAGGGGGAGGAGCAGGCTA	0.552000													9	79					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8521460	8521460	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr9:8521460C>T	ENST00000381196.4	-	17	1321	c.778G>A	c.(778-780)Gtg>Atg	p.V260M	PTPRD_ENST00000540109.1_Missense_Mutation_p.V260M|PTPRD_ENST00000360074.4_Missense_Mutation_p.V247M|PTPRD_ENST00000537002.1_Missense_Mutation_p.V257M|PTPRD_ENST00000358503.5_Missense_Mutation_p.V247M|PTPRD_ENST00000486161.1_Missense_Mutation_p.V260M|PTPRD_ENST00000356435.5_Missense_Mutation_p.V260M|PTPRD_ENST00000355233.5_Missense_Mutation_p.V260M|PTPRD_ENST00000397606.3_Missense_Mutation_p.V250M|PTPRD_ENST00000397611.3_Missense_Mutation_p.V257M|PTPRD_ENST00000397617.3_Missense_Mutation_p.V250M	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	260	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGTGACCCCACGGCCACACAG	0.473000										TSP Lung(15;0.13)			3	58					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3551171	3551171	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr19:3551171G>A	ENST00000355415.2	-	2	489	c.320C>T	c.(319-321)tCc>tTc	p.S107F	AC005786.7_ENST00000589360.1_RNA|MFSD12_ENST00000591878.1_5'UTR|MFSD12_ENST00000398558.4_Missense_Mutation_p.S107F|MFSD12_ENST00000389395.3_Missense_Mutation_p.S107F	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	107					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						GAAGGGGAAGGACAGCAGGAC	0.662000													6	8					0	0	1	0	0
CCDC130	81576	broad.mit.edu	37	19	13873213	13873213	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr19:13873213G>A	ENST00000586600.1	+	10	1177	c.674G>A	c.(673-675)cGc>cAc	p.R225H	CCDC130_ENST00000587019.1_3'UTR|CCDC130_ENST00000221554.8_Missense_Mutation_p.R225H			P13994	CC130_HUMAN	coiled-coil domain containing 130	225					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			GAAGATGACCGCAAGCTGGCG	0.622000													3	38					0	0	1	0	0
CCNT2	905	broad.mit.edu	37	2	135711337	135711337	+	Frame_Shift_Del	DEL	A	A	-			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr2:135711337delA	ENST00000264157.5	+	9	1342	c.1312delA	c.(1312-1314)aafs	p.K438fs	CCNT2_ENST00000295238.6_Frame_Shift_Del_p.K438fs|CCNT2_ENST00000537343.1_Frame_Shift_Del_p.K263fs	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	438					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		GTCTTTAGATAAATATAGAGA	0.393													2	4	---	---	---	---					
SDHAP1	0	broad.mit.edu	37	3	195713385	195713386	+	RNA	INS	-	-	T			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr3:195713385_195713386insT	ENST00000427841.1	-	0	176					NR_003264.2																						AAAGCATGAACTTACGGAATCT	0.401													3	4	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708855	180708855	+	RNA	DEL	G	G	-	rs60396213		TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr5:180708855delG	ENST00000412295.2	+	0	238																											AGCGGTAGGAGGGGGGCTGGA	0.697													6	7	---	---	---	---					
NEUROD6	63974	broad.mit.edu	37	7	31378732	31378732	+	Frame_Shift_Del	DEL	C	C	-			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr7:31378732delC	ENST00000297142.3	-	2	473	c.151delG	c.(151-153)ccfs	p.A51fs		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	51					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						tctccAGGGGCCCTTTTGATG	0.448													16	32	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49447049	49447050	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr12:49447049_49447050delGG	ENST00000301067.7	-	7	893_894	c.894_895delCC	c.(892-897)taatfs	p.YH298fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CAGAAAGTATGGTATCCTTTGT	0.480													25	60	---	---	---	---					
FOXA1	3169	broad.mit.edu	37	14	38061233	38061241	+	In_Frame_Del	DEL	GTTGCCGGA	GTTGCCGGA	-			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr14:38061233_38061241delGTTGCCGGA	ENST00000250448.2	-	2	809_817	c.748_756delTCCGGCAAC	c.(748-756)del	p.SGN250del	FOXA1_ENST00000540786.1_In_Frame_Del_p.SGN217del|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	250					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCTCGAACATGTTGCCGGAGTCCGGGTGC	0.684													9	18	---	---	---	---					
DPF1	0	broad.mit.edu	37	19	38702939	38702939	+	Frame_Shift_Del	DEL	G	G	-			TCGA-V1-A8MM-01A-11D-A377-08	TCGA-V1-A8MM-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c5ad2-f778-4997-84bb-f8a060fc3286	68397e1f-276f-4831-b395-7aec3cffaf4e	g.chr19:38702939delG	ENST00000416611.1	-	11	1230	c.1107delC	c.(1105-1107)ccfs	p.P369fs	DPF1_ENST00000412732.1_Frame_Shift_Del_p.P303fs|DPF1_ENST00000456296.1_Frame_Shift_Del_p.P359fs|DPF1_ENST00000355526.4_Frame_Shift_Del_p.P385fs|DPF1_ENST00000420980.2_Frame_Shift_Del_p.P351fs|DPF1_ENST00000414789.1_Frame_Shift_Del_p.P303fs			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	351					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCTCCGCCATGGGGGGACTCA	0.657													2	4	---	---	---	---					
