Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ERBB2IP	55914	broad.mit.edu	37	5	65322164	65322164	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr5:65322164T>C	ENST00000284037.5	+	13	1444	c.1055T>C	c.(1054-1056)cTc>cCc	p.L352P	ERBB2IP_ENST00000511297.1_Missense_Mutation_p.L352P|ERBB2IP_ENST00000416865.2_Missense_Mutation_p.L352P|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.L352P|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.L352P|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.L352P|ERBB2IP_ENST00000508515.1_Missense_Mutation_p.L352P|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.L352P|ERBB2IP_ENST00000380936.1_Missense_Mutation_p.L352P|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.L352P	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	352					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		GTGCTGTTTCTCCATTCCAAT	0.303000													12	46					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53453374	53453374	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr19:53453374G>A	ENST00000357666.4	-	5	1954	c.1654C>T	c.(1654-1656)Ctt>Ttt	p.L552F	ZNF816_ENST00000434371.2_Intron|ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000444460.2_Missense_Mutation_p.L552F	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	552					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						TGGTTTGCAAGGCATGAATCA	0.403000													14	88					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180992	65180992	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr18:65180992T>G	ENST00000310045.7	-	2	2357	c.884A>C	c.(883-885)aAa>aCa	p.K295T	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	285						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TGTGACGGATTTAGCTGTGTA	0.398000													4	76					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113267582	113267582	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr8:113267582C>A	ENST00000297405.5	-	62	10181	c.9937G>T	c.(9937-9939)Gtt>Ttt	p.V3313F	CSMD3_ENST00000455883.2_Missense_Mutation_p.V3144F|CSMD3_ENST00000352409.3_Missense_Mutation_p.V3243F|CSMD3_ENST00000343508.3_Missense_Mutation_p.V3273F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3313	Sushi 26.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTGAATGAAACCTCTGACTGG	0.423000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	36					2.2171e-23	2.38765e-23	1	1	0
DONSON	29980	broad.mit.edu	37	21	34951736	34951736	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr21:34951736A>G	ENST00000303071.5	-	9	1549	c.1483T>C	c.(1483-1485)Tct>Cct	p.S495P	DONSON_ENST00000303113.6_Missense_Mutation_p.S481P|DONSON_ENST00000453626.1_Intron|DONSON_ENST00000432378.1_Intron	NM_017613.3	NP_060083.1	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	495					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						GCAGAGAAAGATCCACTCTGT	0.428000													43	82					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	79082369	79082369	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr7:79082369T>C	ENST00000354212.4	-	1	521	c.268A>G	c.(268-270)Aag>Gag	p.K90E	MAGI2-AS3_ENST00000429408.1_RNA|MAGI2_ENST00000419488.1_Missense_Mutation_p.K90E|MAGI2_ENST00000522391.1_Missense_Mutation_p.K90E	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	90	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGGGGTCCTTGCAGTGTTTG	0.637000													9	49					0	0	1	0	0
PRMT3	10196	broad.mit.edu	37	11	20424497	20424497	+	Silent	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr11:20424497C>T	ENST00000331079.6	+	8	955	c.738C>T	c.(736-738)ttC>ttT	p.F246F	PRMT3_ENST00000437750.2_Silent_p.F184F	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	246							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						ACCGAGATTTCATATACCAAA	0.353000													24	53					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	30					0	0	1	0	0
IGLV1-47	0	broad.mit.edu	37	22	22712528	22712528	+	RNA	SNP	G	G	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr22:22712528G>C	ENST00000390294.2	+	0	327																											TGGCACCTCAGCCTCCCTGGC	0.597000													53	87					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21169734	21169734	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr10:21169734G>A	ENST00000377122.4	-	5	865	c.469C>T	c.(469-471)Cac>Tac	p.H157Y	NEBL_ENST00000377119.1_Missense_Mutation_p.H157Y|NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	157					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTACTCTGGTGTTTATTGACC	0.403000													7	59					0	0	1	0	0
ACTG1	71	broad.mit.edu	37	17	79479005	79479005	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr17:79479005A>T	ENST00000575842.1	-	2	713	c.287T>A	c.(286-288)gTg>gAg	p.V96E	ACTG1_ENST00000575087.1_Missense_Mutation_p.V96E|ACTG1_ENST00000331925.2_Missense_Mutation_p.V96E|ACTG1_ENST00000573283.1_Missense_Mutation_p.V96E			P63261	ACTG_HUMAN	actin, gamma 1	96					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|lung(8)|ovary(2)|prostate(5)|urinary_tract(1)	29	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CTCCGGGGCCACGCGCAGCTC	0.627000													9	33					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118514553	118514553	+	Silent	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr11:118514553C>T	ENST00000361417.2	+	15	3324	c.2913C>T	c.(2911-2913)agC>agT	p.S971S	PHLDB1_ENST00000527898.1_Silent_p.S7S|PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000524713.1_Silent_p.S114S|PHLDB1_ENST00000356063.5_Silent_p.S924S	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	971										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGGCCACCAGCCCCCTTCCCC	0.662000													13	26					0	0	1	0	0
AMD1	262	broad.mit.edu	37	6	111210071	111210071	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr6:111210071T>G	ENST00000368885.3	+	3	545	c.209T>G	c.(208-210)aTg>aGg	p.M70R	AMD1_ENST00000451850.2_Intron|AMD1_ENST00000368877.5_Missense_Mutation_p.M41R|AMD1_ENST00000368882.3_Intron|AMD1_ENST00000368876.1_Start_Codon_SNP_p.M1R	NM_001634.4	NP_001625.2	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1	70					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	GAGAGTAGCATGTTTGTCTCC	0.388000													18	57					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87018025	87018025	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr3:87018025A>G	ENST00000398399.2	-	3	1015	c.652T>C	c.(652-654)Tcc>Ccc	p.S218P	VGLL3_ENST00000383698.3_Missense_Mutation_p.S218P	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		TGGCTGTAGGATGGGCTCACC	0.607000													8	48					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013446	5013446	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr11:5013446G>C	ENST00000380390.1	+	7	976	c.760G>C	c.(760-762)Gaa>Caa	p.E254Q	MMP26_ENST00000300762.1_Missense_Mutation_p.E254Q			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	254					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TTCCATAGGAGAAAAATGTTC	0.383000													8	35					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151107658	151107658	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:151107658G>A	ENST00000341697.3	-	15	3252	c.1561C>T	c.(1561-1563)Cgg>Tgg	p.R521W				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	521						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCCCATGCCGGGCACACCGG	0.612000													10	32					0	0	1	0	0
C9orf139	401563	broad.mit.edu	37	9	139929144	139929144	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr9:139929144C>A	ENST00000314330.2	+	3	1725	c.211C>A	c.(211-213)Cgc>Agc	p.R71S		NM_207511.1	NP_997394.1	Q6ZV77	CI139_HUMAN	chromosome 9 open reading frame 139	71										cervix(1)|lung(2)	3	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TGTCCTGCCACGCCTGCGGGT	0.657000													21	67					4.26978e-12	4.51146e-12	1	1	0
TCIRG1	10312	broad.mit.edu	37	11	67818000	67818000	+	Silent	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr11:67818000C>T	ENST00000265686.3	+	19	2391	c.2283C>T	c.(2281-2283)ggC>ggT	p.G761G	TCIRG1_ENST00000532635.1_Silent_p.G545G|TCIRG1_ENST00000530802.1_Intron	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	761					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						TAGGCCTGGGCCTGGGCCGGG	0.657000													17	126					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696269	153696269	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chrX:153696269G>A	ENST00000369682.3	+	21	3920	c.3745G>A	c.(3745-3747)Gcg>Acg	p.A1249T		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1249					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GACTCAGGACGCGGACCGTAC	0.677000													12	13					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124812062	124812062	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr12:124812062G>A	ENST00000356219.3	-	46	7252	c.7097C>T	c.(7096-7098)cCg>cTg	p.P2366L	NCOR2_ENST00000429285.2_Missense_Mutation_p.P2349L|NCOR2_ENST00000405201.1_Missense_Mutation_p.P2359L|NCOR2_ENST00000404621.1_Intron|NCOR2_ENST00000397355.1_Intron|NCOR2_ENST00000404121.2_Missense_Mutation_p.P1920L	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2370					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCGCTGAGCGGCGGGGACTC	0.582000													5	58					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17817936	17817936	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr8:17817936G>A	ENST00000325083.8	+	15	2744	c.2305G>A	c.(2305-2307)Gca>Aca	p.A769T	PCM1_ENST00000519253.1_Missense_Mutation_p.A769T|PCM1_ENST00000524226.1_Missense_Mutation_p.A770T	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	769					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		ATTGCAAACGGCATGCCCTGA	0.343000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								3	27					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													5	41					0	0	1	0	0
GPR107	0	broad.mit.edu	37	9	132853235	132853235	+	Silent	SNP	A	A	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr9:132853235A>C	ENST00000372406.1	+	8	1209	c.702A>C	c.(700-702)ccA>ccC	p.P234P	GPR107_ENST00000347136.6_Silent_p.P234P|GPR107_ENST00000372410.3_Silent_p.P234P	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	234						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				AAGAATTGCCAAGTGACAAGT	0.358000													7	30					0	0	1	0	0
KIAA1467	57613	broad.mit.edu	37	12	13215818	13215818	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr12:13215818A>C	ENST00000197268.8	+	5	881	c.761A>C	c.(760-762)aAc>aCc	p.N254T		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	254						integral to membrane				NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TACTTGTCCAACGGTACCTTG	0.493000													5	143					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195690286	195690286	+	RNA	SNP	C	C	G	rs138082028	by1000genomes	TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr3:195690286C>G	ENST00000427841.1	-	0	2209					NR_003264.2																						CTATATTCCACAGTGACCTTG	0.393000													3	24					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803022	157803022	+	Silent	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:157803022G>A	ENST00000368174.4	-	5	1095	c.999C>T	c.(997-999)caC>caT	p.H333H		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	333	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGGTGCAGTCGTGAAACCCCC	0.552000													31	39					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174514	51174514	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr16:51174514C>T	ENST00000440970.1	-	2	1759	c.1328G>A	c.(1327-1329)aGc>aAc	p.S443N	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.S540N	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	540					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTCTAGCCAGCTGGTGACTGG	0.557000													11	31					0	0	1	0	0
PCDHGA3	0	broad.mit.edu	37	5	140723618	140723618	+	Missense_Mutation	SNP	T	T	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr5:140723618T>A	ENST00000253812.6	+	1	18	c.18T>A	c.(16-18)agT>agA	p.S6R	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGCCTGAGTTTCCGAAATG	0.522000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	86					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39853372	39853372	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:39853372A>G	ENST00000564288.1	+	58	15635	c.14858A>G	c.(14857-14859)gAg>gGg	p.E4953G	MACF1_ENST00000317713.7_Missense_Mutation_p.E2891G|MACF1_ENST00000289893.4_Missense_Mutation_p.E3393G|MACF1_ENST00000567887.1_Missense_Mutation_p.E4990G|MACF1_ENST00000372915.3_Missense_Mutation_p.E4958G|MACF1_ENST00000539005.1_Missense_Mutation_p.E2870G|MACF1_ENST00000545844.1_Missense_Mutation_p.E2891G|MACF1_ENST00000361689.2_Missense_Mutation_p.E2891G			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4958					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AATGAGGTGGAGAAGCGCCGC	0.483000													7	24					0	0	1	0	0
IL17REL	400935	broad.mit.edu	37	22	50437763	50437763	+	Silent	SNP	C	C	T	rs148168797		TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr22:50437763C>T	ENST00000389983.2	-	9	822	c.558G>A	c.(556-558)gcG>gcA	p.A186A	IL17REL_ENST00000341280.5_Silent_p.A186A	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	186										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CGTCAGGGGTCGCAGACCAGC	0.677000													10	61					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88560143	88560143	+	Silent	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr12:88560143A>G	ENST00000266712.6	+	7	1054	c.834A>G	c.(832-834)acA>acG	p.T278T		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	278						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						CAACTCCTACAAGGCAACTAA	0.348000													4	56					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220412497	220412497	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr2:220412497G>A	ENST00000344458.2	+	4	1021	c.436G>A	c.(436-438)Gtg>Atg	p.V146M	TMEM198_ENST00000373883.3_Missense_Mutation_p.V146M			Q66K66	TM198_HUMAN	transmembrane protein 198	146	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCCAGGCTCCGTGTGGGGTCC	0.721000													6	21					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44693760	44693760	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr20:44693760C>T	ENST00000290231.6	-	6	901	c.737G>A	c.(736-738)aGc>aAc	p.S246N		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				ACCTCCCCTGCTAACATCCTC	0.527000													21	75					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104044027	104044027	+	Splice_Site	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr4:104044027C>T	ENST00000265148.3	-	43	7233		c.e43+1		CENPE_ENST00000380026.3_Splice_Site	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AAATTATATACCTCTGTGGTT	0.343000													8	54					0	0	1	0	0
C10orf11	83938	broad.mit.edu	37	10	77806998	77806998	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr10:77806998A>C	ENST00000372499.1	+	3	466	c.251A>C	c.(250-252)aAc>aCc	p.N84T	C10orf11_ENST00000593699.1_3'UTR	NM_032024.3	NP_114413.1	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	84										endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	10	Prostate(51;0.0095)|all_epithelial(25;0.0221)					CTGCTGGGCAACGTGGCCTGT	0.517000													9	55					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44644994	44644994	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr20:44644994G>T	ENST00000372330.3	+	13	2130	c.2111G>T	c.(2110-2112)tGc>tTc	p.C704F	RP11-465L10.10_ENST00000535913.1_RNA	NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	704	Hemopexin-like 4.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	ATCCTGCAGTGCCCTGAGGAC	0.582000													9	33					0.000274275	0.000279262	1	1	0
SHPRH	257218	broad.mit.edu	37	6	146242326	146242326	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr6:146242326C>T	ENST00000367503.3	-	21	4395	c.3997G>A	c.(3997-3999)Gaa>Aaa	p.E1333K	SHPRH_ENST00000275233.7_Missense_Mutation_p.E1329K|SHPRH_ENST00000367505.2_Missense_Mutation_p.E1329K|SHPRH_ENST00000438092.2_Missense_Mutation_p.E1333K	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1329					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTCCATGCTTCAAAGAGATCC	0.303000													4	17					0	0	1	0	0
DSCC1	79075	broad.mit.edu	37	8	120865380	120865380	+	Silent	SNP	T	T	C			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr8:120865380T>C	ENST00000313655.4	-	2	472	c.258A>G	c.(256-258)gcA>gcG	p.A86A		NM_024094.2	NP_076999.2	Q9BVC3	DCC1_HUMAN	DNA replication and sister chromatid cohesion 1	86					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|pancreas(1)	9	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGGAAGTGTCTGCTATCTTCA	0.408000													13	92					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63027353	63027353	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:63027353A>T	ENST00000251157.5	-	19	2167	c.2134T>A	c.(2134-2136)Tgg>Agg	p.W712R	DOCK7_ENST00000340370.5_Missense_Mutation_p.W712R	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	712	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TTATCTACCCATTTCATGCCA	0.289000													14	59					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68947142	68947142	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:68947142G>A	ENST00000456315.2	-	9	2030	c.1916C>T	c.(1915-1917)gCa>gTa	p.A639V	DEPDC1_ENST00000370966.5_Missense_Mutation_p.A355V|RP4-694A7.2_ENST00000425820.1_RNA	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	639	Interaction with ZNF224.				intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CGTACCCATTGCATCATGAAG	0.353000													3	55					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181701857	181701857	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:181701857C>T	ENST00000526775.1	+	19	2743	c.2578C>T	c.(2578-2580)Cgg>Tgg	p.R860W	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R879W|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R860W|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R486W|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R811W|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R879W|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R830W	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	879					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCTGGGCCAGCGGGAGCCACC	0.672000													11	17					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	135965348	135965348	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr2:135965348C>A	ENST00000401392.1	-	19	2871	c.2659G>T	c.(2659-2661)Gat>Tat	p.D887Y	ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000536680.1_Missense_Mutation_p.D887Y|ZRANB3_ENST00000264159.6_Missense_Mutation_p.D889Y			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	889						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		ACAGTGAGATCTGCCTGGACT	0.423000													4	47					1	1	1	1	0
MALAT1	0	broad.mit.edu	37	11	65271416	65271416	+	RNA	SNP	T	T	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr11:65271416T>G	ENST00000534336.1	+	0	6184					NR_002819.2																						ATTACACATTTTATTTCCAGA	0.333000													5	11					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55120018	55120018	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr6:55120018A>G	ENST00000370862.3	+	3	823	c.487A>G	c.(487-489)Aag>Gag	p.K163E		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	163					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTTGATGTTTAAGAGCACAGC	0.493000													9	51					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103908	53103908	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr7:53103908C>A	ENST00000408890.4	+	1	560	c.544C>A	c.(544-546)Ctc>Atc	p.L182I		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	182										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GCTGGGGGCGCTCAGCCAGTG	0.721000													9	23					9.70103e-10	1.00603e-09	1	1	0
CIT	11113	broad.mit.edu	37	12	120288024	120288024	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr12:120288024A>T	ENST00000392521.2	-	5	525	c.470T>A	c.(469-471)aTc>aAc	p.I157N	CIT_ENST00000261833.7_Missense_Mutation_p.I157N	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	157	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TAATTGGGGGATCCACGGGCT	0.408000													6	176					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58567470	58567470	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr20:58567470G>A	ENST00000348616.4	+	10	1621	c.1321G>A	c.(1321-1323)Gtc>Atc	p.V441I	CDH26_ENST00000244047.5_Missense_Mutation_p.V441I	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	441	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TTGGGTCAGCGTCGACAAAAA	0.378000													11	37					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52947299	52947319	+	Splice_Site	DEL	GCCTTCAATCTATATAAAAAG	GCCTTCAATCTATATAAAAAG	-			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr1:52947299_52947319delGCCTTCAATCTATATAAAAAG	ENST00000371544.3	-	11	1898_1906	c.1635_splice	c.e11-1	p.546_splice	ZCCHC11_ENST00000257177.4_Splice_Site_p.546_splice|ZCCHC11_ENST00000371541.1_5'UTR	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	546					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding	p.E547*(1)		NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TTGGGTCAAAGCCTTCAATCTATATAAAAAGGCATTCCAAA	0.335													12	47	---	---	---	---					
SLC26A2	1836	broad.mit.edu	37	5	149357907	149357907	+	Frame_Shift_Del	DEL	T	T	-			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr5:149357907delT	ENST00000286298.4	+	2	960	c.692delT	c.(691-693)gtfs	p.V231fs		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	231						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATAGCTGGAGTTTATCAGGTA	0.343													11	45	---	---	---	---					
ACTR6	64431	broad.mit.edu	37	12	100617651	100617657	+	Frame_Shift_Del	DEL	AGAAAAT	AGAAAAT	-			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr12:100617651_100617657delAGAAAAT	ENST00000188312.2	+	11	1914_1920	c.1149_1155delAGAAAAT	c.(1147-1155)gafs	p.EEN383fs	ACTR6_ENST00000546902.1_Frame_Shift_Del_p.EEN301fs|ACTR6_ENST00000551617.1_Frame_Shift_Del_p.EEN281fs|ACTR6_ENST00000552376.1_Frame_Shift_Del_p.EEN363fs	NM_022496.4	NP_071941.1	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog (yeast)	383						cytoplasm|cytoskeleton		p.E384K(1)		autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14						AAGATTACGAAGAAAATGGACATAGCG	0.329													7	46	---	---	---	---					
MBD1	4152	broad.mit.edu	37	18	47806259	47806260	+	Frame_Shift_Ins	INS	-	-	A			TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr18:47806259_47806260insA	ENST00000591416.1	-	2	534_535	c.103_104insT	c.(103-105)ccafs	p.P35fs	MBD1_ENST00000587605.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000382948.5_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000353909.3_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000349085.2_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000347968.3_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000398495.2_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000269468.5_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000269471.5_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000585672.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000585595.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000457839.2_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000436910.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000424334.2_Frame_Shift_Ins_p.P61fs|MBD1_ENST00000398488.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000398493.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000590208.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000591535.1_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000339998.6_Frame_Shift_Ins_p.P35fs|MBD1_ENST00000588937.1_Frame_Shift_Ins_p.P35fs			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	35	MBD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						GTACCTCTGGTAATAGGTGTCT	0.554													19	21	---	---	---	---					
CARD10	29775	broad.mit.edu	37	22	37900248	37900249	+	Frame_Shift_Ins	INS	-	-	G	rs35832225		TCGA-V1-A8WV-01A-11D-A377-08	TCGA-V1-A8WV-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb3d2a6b-9f91-4cc4-8f42-129e41672023	84819ecf-df76-4072-96dc-6a298f4b3b0c	g.chr22:37900248_37900249insG	ENST00000403299.1	-	10	1794_1795	c.1578_1579insC	c.(1576-1581)ccgtgcfs	p.C527fs	CARD10_ENST00000251973.5_Frame_Shift_Ins_p.C527fs|CARD10_ENST00000406271.3_Frame_Shift_Ins_p.C241fs			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	527					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					GAGCCGGCACTGGGGGGGAAGG	0.639													2	4	---	---	---	---					
