Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BTBD7	55727	broad.mit.edu	37	14	93708856	93708856	+	Silent	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr14:93708856G>A	ENST00000334746.5	-	11	3469	c.3162C>T	c.(3160-3162)gtC>gtT	p.V1054V	BTBD7_ENST00000393170.2_Silent_p.V628V|BTBD7_ENST00000554565.1_Silent_p.V703V	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	1054										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		TTCGTCCCCTGACATGGGCTG	0.527000													41	77					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114215328	114215328	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr1:114215328G>A	ENST00000369615.1	+	18	3072	c.3010G>A	c.(3010-3012)Gca>Aca	p.A1004T	MAGI3_ENST00000369617.4_Missense_Mutation_p.A1029T|MAGI3_ENST00000307546.9_Missense_Mutation_p.A1004T|MAGI3_ENST00000369611.4_Missense_Mutation_p.A1004T	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	1029					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTGACACCGCAGTAATTTC	0.458000													4	225					0	0	1	0	0
LAPTM4B	55353	broad.mit.edu	37	8	98817641	98817641	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr8:98817641A>G	ENST00000445593.2	+	2	1113	c.433A>G	c.(433-435)Aac>Gac	p.N145D	LAPTM4B_ENST00000521545.2_Missense_Mutation_p.N54D	NM_018407.4	NP_060877.3	Q86VI4	LAP4B_HUMAN	lysosomal protein transmembrane 4 beta	198					transport	endomembrane system|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	10	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)			GGATCAGTATAACTTTTCAAG	0.378000													43	80					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128186	152128186	+	Silent	SNP	A	A	G			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr1:152128186A>G	ENST00000316073.3	-	3	1453	c.1389T>C	c.(1387-1389)taT>taC	p.Y463Y		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	463	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTCTGACCATAGTGGGAAC	0.512000													7	631					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													5	110					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95064090	95064090	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr9:95064090T>C	ENST00000545558.1	-	13	3410	c.2918A>G	c.(2917-2919)aAa>aGa	p.K973R	NOL8_ENST00000442668.2_Missense_Mutation_p.K973R|NOL8_ENST00000358855.4_Missense_Mutation_p.K905R|NOL8_ENST00000535387.1_Missense_Mutation_p.K935R|NOL8_ENST00000542053.1_Missense_Mutation_p.K905R			Q76FK4	NOL8_HUMAN	nucleolar protein 8	973					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CCTTTTCTTTTTTCGTTTTGC	0.313000													3	3					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349039	56349039	+	Silent	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr17:56349039G>A	ENST00000340482.3	-	10	2279	c.2103C>T	c.(2101-2103)ttC>ttT	p.F701F	MPO_ENST00000225275.3_Silent_p.F669F			P05164	PERM_HUMAN	myeloperoxidase	669					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GGAGCTTCCTGAACTGGGTAC	0.642000													8	18					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25982350	25982350	+	Splice_Site	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr2:25982350C>T	ENST00000435504.4	-	9	1233		c.e9+1		ASXL2_ENST00000272341.4_Splice_Site|ASXL2_ENST00000336112.4_Splice_Site|ASXL2_ENST00000404843.1_Splice_Site			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAATGACGCACCTGTCGATCT	0.373000													19	42					0	0	1	0	0
DLX5	1749	broad.mit.edu	37	7	96653671	96653671	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr7:96653671C>T	ENST00000222598.4	-	1	738	c.265G>A	c.(265-267)Gcc>Acc	p.A89T	DLX5_ENST00000493764.1_5'UTR|DLX5_ENST00000486603.2_Missense_Mutation_p.A89T	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	89					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					TAAGCTTTGGCTGGGTAGCTC	0.602000													20	29					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624745	154624745	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr4:154624745T>C	ENST00000260010.6	+	1	2094	c.686T>C	c.(685-687)cTg>cCg	p.L229P		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	229					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TGTTTGGAACTGCGAGATACT	0.338000													26	49					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895268	77895268	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr18:77895268G>A	ENST00000262198.4	+	4	2427	c.1972G>A	c.(1972-1974)Ggc>Agc	p.G658S		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	658					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G658S(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		TTCCATGCCCGGCATGCCCTC	0.632000													3	46					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125887739	125887739	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr5:125887739G>C	ENST00000409134.3	-	14	1510	c.1291C>G	c.(1291-1293)Ccg>Gcg	p.P431A	ALDH7A1_ENST00000447989.2_Missense_Mutation_p.P394A|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.P367A	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	431					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TAGAGAATCGGAGCAAAAGTC	0.398000													5	28					0	0	1	0	0
EYA3	2140	broad.mit.edu	37	1	28365380	28365380	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr1:28365380T>C	ENST00000373871.3	-	5	434	c.194A>G	c.(193-195)aAt>aGt	p.N65S	EYA3_ENST00000373863.3_Missense_Mutation_p.N65S|EYA3_ENST00000545175.1_Missense_Mutation_p.N12S|EYA3_ENST00000540618.1_Missense_Mutation_p.N65S|EYA3_ENST00000373864.1_Start_Codon_SNP_p.M1V|EYA3_ENST00000471498.1_5'UTR|EYA3_ENST00000436342.2_5'UTR			Q99504	EYA3_HUMAN	eyes absent homolog 3 (Drosophila)	65					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		GGTATAATCATTGGATGAGCG	0.303000													20	31					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285788	16285788	+	Silent	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr17:16285788C>T	ENST00000302182.3	+	2	959	c.567C>T	c.(565-567)ccC>ccT	p.P189P	UBB_ENST00000578649.1_3'UTR|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395837.1_Silent_p.P189P|UBB_ENST00000395839.1_Silent_p.P189P|UBB_ENST00000535788.1_Silent_p.P113P	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	189	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding	p.P189P(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AAGGCATCCCCCCCGACCAGC	0.552000													4	58					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145838644	145838644	+	Silent	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr5:145838644G>A	ENST00000296702.5	+	4	674	c.636G>A	c.(634-636)caG>caA	p.Q212Q	TCERG1_ENST00000394421.2_Silent_p.Q212Q	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	212	Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity	p.Q212Q(1)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ctcaggcccaggcccaggccc	0.736000													3	30					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066665	9066665	+	Missense_Mutation	SNP	C	C	T	rs151007766		TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr5:9066665C>T	ENST00000382496.5	-	17	2832	c.2167G>A	c.(2167-2169)Ggc>Agc	p.G723S		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	723	TSP type-1 4.			G -> D (in Ref. 1; AAC09473).	cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TCATAGTGGCCGCCGTTGTCA	0.547000													12	88					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52383622	52383622	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr19:52383622G>A	ENST00000420592.1	-	3	1347	c.14C>T	c.(13-15)aCg>aTg	p.T5M	ZNF577_ENST00000412216.1_Missense_Mutation_p.T5M|ZNF577_ENST00000301399.5_Missense_Mutation_p.T5M|ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000451628.2_Missense_Mutation_p.T5M			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		cattacaatcgtggcattttt	0.418000													51	67					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21767171	21767171	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr8:21767171C>T	ENST00000276420.4	-	5	1148	c.890G>A	c.(889-891)gGg>gAg	p.G297E	DOK2_ENST00000544659.1_Missense_Mutation_p.G143E	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	297					blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GGCATACTCCCCCTCCTGGCC	0.677000													20	44					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919742	4919742	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr12:4919742G>A	ENST00000433855.1	+	1	1401	c.535G>A	c.(535-537)Gtc>Atc	p.V179I	KCNA6_ENST00000280684.3_Missense_Mutation_p.V179I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	179						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.V179I(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CATCGCCATCGTCTCCGTGTT	0.592000										HNSCC(72;0.22)			22	28					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29598982	29598982	+	Silent	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr13:29598982C>T	ENST00000431530.3	+	1	235	c.177C>T	c.(175-177)gaC>gaT	p.D59D		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	49						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CCTCTCATGACGAGTCCAAGA	0.418000													7	19					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029733	150029733	+	Silent	SNP	G	G	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr5:150029733G>T	ENST00000394243.1	+	3	3002	c.2628G>T	c.(2626-2628)ctG>ctT	p.L876L	SYNPO_ENST00000519664.1_Silent_p.L632L|SYNPO_ENST00000307662.4_Silent_p.L632L|SYNPO_ENST00000522122.1_Silent_p.L876L	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	876	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGACAGCCTGCAGCCCACTG	0.716000													32	54					5.09552e-08	5.40749e-08	1	1	0
MYOCD	93649	broad.mit.edu	37	17	12656007	12656007	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr17:12656007G>A	ENST00000425538.1	+	10	1602	c.1402G>A	c.(1402-1404)Gct>Act	p.A468T	MYOCD_ENST00000343344.4_Missense_Mutation_p.A468T|MYOCD_ENST00000395988.1_Missense_Mutation_p.A372T	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	468	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding	p.A468T(1)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCTGTCAGTCGCTGGGTCCCT	0.627000													17	36					0	0	1	0	0
OAS2	0	broad.mit.edu	37	12	113448256	113448256	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr12:113448256A>T	ENST00000342315.4	+	11	2341	c.2127A>T	c.(2125-2127)agA>agT	p.R709S	RP1-71H24.1_ENST00000552784.1_RNA|OAS2_ENST00000392583.2_3'UTR	NM_016817.2	NP_058197.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	709					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GAAGCCATAGAATCCTGAATA	0.403000													66	131					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113719371	113719371	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr13:113719371C>T	ENST00000397030.1	+	7	864	c.827C>T	c.(826-828)gCg>gTg	p.A276V	MCF2L_ENST00000375601.3_Missense_Mutation_p.A247V|MCF2L_ENST00000535094.2_Missense_Mutation_p.A243V|MCF2L_ENST00000375604.2_Missense_Mutation_p.A300V|MCF2L_ENST00000423482.2_Missense_Mutation_p.A241V|MCF2L_ENST00000375597.4_Missense_Mutation_p.A241V|MCF2L_ENST00000434480.2_Missense_Mutation_p.A249V|MCF2L_ENST00000442652.2_Missense_Mutation_p.A273V|MCF2L_ENST00000421756.1_Missense_Mutation_p.A247V|MCF2L_ENST00000375608.3_Missense_Mutation_p.A273V			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	273					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GTGCTGTGTGCGCACACAGAG	0.622000													3	53					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241399	163241399	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr2:163241399G>T	ENST00000332142.5	-	13	2860	c.2761C>A	c.(2761-2763)Cag>Aag	p.Q921K		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	921					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TTGGAACTCTGATAATGTCTT	0.343000													33	58					7.11191e-15	8.03955e-15	1	1	0
CDH4	1002	broad.mit.edu	37	20	60419780	60419780	+	Silent	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr20:60419780C>T	ENST00000360469.5	+	5	721	c.633C>T	c.(631-633)ggC>ggT	p.G211G	CDH4_ENST00000543233.1_Silent_p.G137G	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	211	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGGGAGTGGGCGCCGACCAGC	0.597000													10	27					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945083	151945083	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr7:151945083C>T	ENST00000355193.2	-	14	2654	c.2436G>A	c.(2434-2436)atG>atA	p.M812I	KMT2C_ENST00000262189.6_Missense_Mutation_p.M812I					lysine (K)-specific methyltransferase 2C																		AAGTTGTTGGCATGATGTTTC	0.448000													32	275					0	0	1	0	0
TAF6L	10629	broad.mit.edu	37	11	62546423	62546423	+	Silent	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr11:62546423G>A	ENST00000294168.3	+	6	720	c.519G>A	c.(517-519)ccG>ccA	p.P173P	TMEM223_ENST00000527073.1_Intron	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	173					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						GGGATGATCCGCAACTGATGA	0.473000													4	81					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17573324	17573324	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr8:17573324G>C	ENST00000381869.3	-	4	2847	c.2374C>G	c.(2374-2376)Cct>Gct	p.P792A	MTUS1_ENST00000544260.1_5'UTR|MTUS1_ENST00000519263.1_Missense_Mutation_p.P792A|MTUS1_ENST00000262102.6_Missense_Mutation_p.P846A|MTUS1_ENST00000381861.3_Missense_Mutation_p.P93A	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	846						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		GATACCAAAGGCTTCAAATAA	0.433000													47	67					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56572509	56572509	+	Silent	SNP	C	C	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr17:56572509C>A	ENST00000323456.5	-	16	3118	c.2994G>T	c.(2992-2994)ctG>ctT	p.L998L	MTMR4_ENST00000579925.1_Silent_p.L941L	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	998						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AAGGGCAGTTCAGTGGAACGG	0.507000													4	126					0.00909568	0.00945951	1	1	0
CPT2	1376	broad.mit.edu	37	1	53679183	53679183	+	Silent	SNP	C	C	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr1:53679183C>A	ENST00000371486.3	+	5	2408	c.1893C>A	c.(1891-1893)cgC>cgA	p.R631R	RP5-1024G6.2_ENST00000452466.1_RNA	NM_000098.2	NP_000089.1	P23786	CPT2_HUMAN	carnitine palmitoyltransferase 2	631			R -> C (in CPT2D; early-onset hepatocardiomuscular form).		carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	ACCCAGGCCGCAATGCCCGGG	0.498000													30	25					1.38854e-25	1.60454e-25	1	1	0
ESRP1	54845	broad.mit.edu	37	8	95680237	95680237	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr8:95680237G>A	ENST00000433389.2	+	10	1182	c.992G>A	c.(991-993)cGg>cAg	p.R331Q	ESRP1_ENST00000423620.2_Missense_Mutation_p.R331Q|ESRP1_ENST00000358397.5_Missense_Mutation_p.R331Q|ESRP1_ENST00000454170.2_Missense_Mutation_p.R331Q	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	331	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						GTCCGCATGCGGGGGCTCCCT	0.493000													15	44					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540699	187540699	+	Silent	SNP	G	G	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr4:187540699G>A	ENST00000441802.2	-	10	7250	c.7041C>T	c.(7039-7041)acC>acT	p.T2347T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2347	Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CGTAATCCAGGGTTCTGAGTA	0.488000										HNSCC(5;0.00058)			56	87					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57435234	57435234	+	Silent	SNP	G	G	A	rs143507529	byFrequency	TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr12:57435234G>A	ENST00000442789.2	-	14	1433	c.1146C>T	c.(1144-1146)taC>taT	p.Y382Y	MYO1A_ENST00000544473.1_Silent_p.Y220Y|MYO1A_ENST00000300119.3_Silent_p.Y382Y	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	382	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TCTCAAAACCGTAGATATCAA	0.547000													40	61					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49288743	49288743	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr15:49288743C>T	ENST00000559471.1	-	17	2707	c.2444G>A	c.(2443-2445)aGg>aAg	p.R815K	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.R770K	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	815										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						ATATGCTTTCCTGGCCTCCTC	0.378000													44	74					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25064144	25064144	+	Frame_Shift_Del	DEL	T	T	-			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr2:25064144delT	ENST00000260600.5	-	5	2031	c.1180delA	c.(1180-1182)tgfs	p.M394fs	ADCY3_ENST00000405392.1_Frame_Shift_Del_p.M5fs	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	394					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCCTCCACCATGGCCAGCCCC	0.657													2	4	---	---	---	---					
CDC25A	993	broad.mit.edu	37	3	48200922	48200923	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr3:48200922_48200923delTC	ENST00000302506.3	-	14	1753_1754	c.1345_1346delGA	c.(1345-1347)tfs	p.D449fs	CDC25A_ENST00000351231.3_Frame_Shift_Del_p.D409fs	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	449	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACCCAGGCGATCTCTCTCTCTC	0.515													7	82	---	---	---	---					
PSD3	23362	broad.mit.edu	37	8	18432657	18432665	+	In_Frame_Del	DEL	CCCTCCAGT	CCCTCCAGT	-			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr8:18432657_18432665delCCCTCCAGT	ENST00000440756.2	-	13	2720_2728	c.2618_2626delACTGGAGGG	c.(2617-2628)gtc>g	p.DWRV873del	PSD3_ENST00000327040.8_In_Frame_Del_p.DWRV871del|PSD3_ENST00000428502.2_In_Frame_Del_p.DWRV200del|PSD3_ENST00000286485.8_In_Frame_Del_p.DWRV337del|PSD3_ENST00000523619.1_In_Frame_Del_p.DWRV806del			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	872	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AAAAGCAAGACCCTCCAGTCGGCAGTTTT	0.397													13	90	---	---	---	---					
ZNF658	26149	broad.mit.edu	37	9	40789482	40789483	+	Splice_Site	INS	-	-	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr9:40789482_40789483insA	ENST00000602553.1	-	2	94		c.e2-2		ZNF658_ENST00000441795.1_Splice_Site|ZNF658_ENST00000377626.3_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCATGTGCCTAAAAAAAAAAA	0.426													2	4	---	---	---	---					
PDCD11	22984	broad.mit.edu	37	10	105191973	105191974	+	Frame_Shift_Ins	INS	-	-	A			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr10:105191973_105191974insA	ENST00000369797.3	+	22	3550_3551	c.3456_3457insA	c.(3454-3459)gtcttgfs	p.VL1152fs		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1152	S1 motif 10.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GCCAGACTGTTACTTGCTTCTT	0.446													41	55	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													6	4	---	---	---	---					
RP11-178C3.2	0	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													3	6	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-V1-A9OT-01A-11D-A41K-08	TCGA-V1-A9OT-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3a578d0f-5710-413d-a40a-e75f63e7042a	9c425266-08aa-46b4-b0b1-6c33962b10da	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			2	4	---	---	---	---					
