Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OAS3	4940	broad.mit.edu	37	12	113384760	113384760	+	Silent	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr12:113384760C>T	ENST00000228928.7	+	4	1028	c.849C>T	c.(847-849)ttC>ttT	p.F283F	RP1-71H24.1_ENST00000552784.1_RNA|OAS3_ENST00000546638.1_3'UTR	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	283	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						TTGGGCAGTTCTTGCAGCGGC	0.557000													5	27					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	87					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169837159	169837159	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr4:169837159T>G	ENST00000335742.7	+	17	3663	c.2306T>G	c.(2305-2307)cTc>cGc	p.L769R	CBR4_ENST00000509108.1_Intron|PALLD_ENST00000507735.1_Missense_Mutation_p.L440R|PALLD_ENST00000505667.1_Missense_Mutation_p.L944R|PALLD_ENST00000261509.6_Missense_Mutation_p.L927R|PALLD_ENST00000512127.1_Missense_Mutation_p.L545R			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1151	Interaction with EPS8 (By similarity).|Pro-rich.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GAAGGAAAACTCTGCAGAATG	0.443000									Pancreatic Cancer, Familial Clustering of				11	36					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526134	70526134	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr18:70526134A>T	ENST00000327305.6	-	4	1053	c.396T>A	c.(394-396)ttT>ttA	p.F132L	NETO1_ENST00000583169.1_Missense_Mutation_p.F132L|NETO1_ENST00000397929.1_Missense_Mutation_p.F131L|NETO1_ENST00000299430.2_Missense_Mutation_p.F131L|NETO1_ENST00000580049.1_5'UTR	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	132	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TAATCCATAGAAATCTTCCAC	0.348000													21	72					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80789374	80789374	+	Silent	SNP	G	G	A	rs141585758		TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr17:80789374G>A	ENST00000269394.3	-	2	1790	c.957C>T	c.(955-957)taC>taT	p.Y319Y	ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|TBCD_ENST00000539345.2_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	319						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTAAAATCCGTAAGGAATCG	0.537000													4	175					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228172604	228172604	+	Silent	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr2:228172604A>G	ENST00000396578.3	+	48	4593	c.4431A>G	c.(4429-4431)caA>caG	p.Q1477Q	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1477	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTTTTGTACAAGGAAATCAAC	0.473000													10	34					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5140517	5140517	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr16:5140517T>C	ENST00000427587.4	-	5	460	c.392A>G	c.(391-393)tAc>tGc	p.Y131C	FAM86A_ENST00000587133.1_Missense_Mutation_p.Y70C|FAM86A_ENST00000458008.4_Missense_Mutation_p.Y97C	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	131										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						TGTGGTACCGTAGGAGATGAT	0.617000													11	72					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129807533	129807533	+	Silent	SNP	C	C	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr11:129807533C>A	ENST00000358825.5	-	8	1230	c.999G>T	c.(997-999)gtG>gtT	p.V333V	PRDM10_ENST00000526082.1_Silent_p.V247V|PRDM10_ENST00000304538.6_Silent_p.V247V|PRDM10_ENST00000360871.3_Silent_p.V333V|PRDM10_ENST00000528746.1_Silent_p.V307V|PRDM10_ENST00000423662.2_Silent_p.V247V	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TTTTCTGGTTCACGAACTCAG	0.363000													7	32					0.0381472	0.0381472	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72832434	72832434	+	Nonsense_Mutation	SNP	C	C	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr16:72832434C>A	ENST00000268489.5	-	9	4819	c.4147G>T	c.(4147-4149)Gaa>Taa	p.E1383*	ZFHX3_ENST00000397992.5_Nonsense_Mutation_p.E469*	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1383					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCATGCACTTCATTAAAATGC	0.502000													18	33					5.03518e-11	5.28694e-11	1	1	0
EIF5A	1984	broad.mit.edu	37	17	7214340	7214340	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr17:7214340C>T	ENST00000336458.8	+	3	570	c.169C>T	c.(169-171)Cat>Tat	p.H57Y	EIF5A_ENST00000571955.1_Missense_Mutation_p.H57Y|EIF5A_ENST00000416016.2_Missense_Mutation_p.H57Y|EIF5A_ENST00000572815.1_Missense_Mutation_p.H57Y|EIF5A_ENST00000419711.2_Missense_Mutation_p.H57Y|EIF5A_ENST00000576930.1_Missense_Mutation_p.H57Y|EIF5A_ENST00000573542.1_Missense_Mutation_p.H57Y|EIF5A_ENST00000336452.7_Missense_Mutation_p.H87Y	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	57	DOHH-binding.				induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						CATACAGGTCCATCTGGTTGG	0.403000													9	74					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10933879	10933879	+	Missense_Mutation	SNP	C	C	T	rs149228869		TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr21:10933879C>T	ENST00000298232.7	-	16	1313	c.946G>A	c.(946-948)Gta>Ata	p.V316I	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.V334I|TPTE_ENST00000342420.5_Missense_Mutation_p.V296I	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	334	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAATCGCTACGATGTTTTCA	0.313000													19	280					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30884915	30884915	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr6:30884915C>T	ENST00000321897.5	+	8	1419	c.787C>T	c.(787-789)Cgg>Tgg	p.R263W	VARS2_ENST00000542001.1_Missense_Mutation_p.R123W|VARS2_ENST00000541562.1_Missense_Mutation_p.R293W|VARS2_ENST00000416670.2_Missense_Mutation_p.R263W			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	263					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity	p.R263W(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						AGCTTTTGTGCGGCTCTACAA	0.557000													4	100					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210668	59210668	+	Silent	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr11:59210668C>T	ENST00000302030.2	+	1	52	c.27C>T	c.(25-27)agC>agT	p.S9S		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CCTGGAACAGCTCATCAGTGA	0.507000													8	34					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235887435	235887435	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:235887435C>T	ENST00000389794.3	-	39	9382	c.9208G>A	c.(9208-9210)Gaa>Aaa	p.E3070K	LYST_ENST00000389793.2_Missense_Mutation_p.E3070K|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3070					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTAATTTCTTCATATGTCCAG	0.353000													10	46					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828505	76828505	+	Silent	SNP	T	T	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr7:76828505T>A	ENST00000248598.5	-	1	638	c.606A>T	c.(604-606)tcA>tcT	p.S202S	CCDC146_ENST00000431197.1_Intron|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	202					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TACCTGGACGTGACTGTATTT	0.318000													7	55					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	157081476	157081476	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr3:157081476C>T	ENST00000362010.2	-	9	1719	c.1412G>A	c.(1411-1413)gGa>gAa	p.G471E	VEPH1_ENST00000392832.2_Missense_Mutation_p.G471E|VEPH1_ENST00000392833.2_Missense_Mutation_p.G471E|VEPH1_ENST00000543418.1_Missense_Mutation_p.G471E|RP11-550I24.2_ENST00000487238.1_RNA	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	471						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TGGTATGTCTCCCCTGTTTTC	0.468000													12	64					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42598785	42598785	+	Silent	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr15:42598785A>G	ENST00000318010.8	+	7	840	c.600A>G	c.(598-600)ggA>ggG	p.G200G	GANC_ENST00000566442.1_Silent_p.G200G	NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	200					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGAAATTTGGAAAATTTGTGG	0.328000													5	24					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41075904	41075904	+	Splice_Site	SNP	C	C	T	rs146661515	by1000genomes	TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chrX:41075904C>T	ENST00000324545.7	+	35	6717	c.6085_splice	c.e35+1	p.P2028_splice	USP9X_ENST00000378308.2_Splice_Site_p.P2028_splice	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2028					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						ACCCTCCTCCCGGTGAGTATC	0.323000													9	15					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306299	2306299	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr4:2306299C>T	ENST00000290974.2	-	8	2107	c.1768G>A	c.(1768-1770)Gtc>Atc	p.V590I	RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.V520I|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.V560I	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	590					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GCACCAATGACGCCTCCCGGG	0.667000													4	19					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43652801	43652801	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chrX:43652801G>C	ENST00000378069.4	-	8	940	c.793C>G	c.(793-795)Cct>Gct	p.P265A	MAOB_ENST00000538942.1_Missense_Mutation_p.P249A|MAOB_ENST00000536181.1_Missense_Mutation_p.P249A	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	265					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	AGAGTAGGAGGAATAGCACTA	0.408000													12	15					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17314696	17314696	+	Silent	SNP	G	G	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:17314696G>A	ENST00000452699.1	-	25	2970	c.2781C>T	c.(2779-2781)agC>agT	p.S927S	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Silent_p.S888S|ATP13A2_ENST00000326735.8_Silent_p.S932S	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	932					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		ACTTGAAGACGCTGAACGAAG	0.607000													9	30					0	0	1	0	0
CTD-2620I22.1	0	broad.mit.edu	37	19	53472914	53472914	+	RNA	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr19:53472914A>G	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							TTTGATTTTCAATTAAAAACC	0.338000													3	21					0	0	1	0	0
RSPO1	284654	broad.mit.edu	37	1	38079477	38079477	+	Missense_Mutation	SNP	C	C	T	rs143117795	by1000genomes	TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:38079477C>T	ENST00000356545.2	-	7	1311	c.524G>A	c.(523-525)cGg>cAg	p.R175Q	RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000373059.1_Missense_Mutation_p.R148Q|RSPO1_ENST00000401070.1_Intron|RSPO1_ENST00000401068.1_Missense_Mutation_p.R175Q|RSPO1_ENST00000401069.1_Missense_Mutation_p.R175Q	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	175	TSP type-1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCTGCGTGTCCGCTCCTCGGA	0.637000													8	49					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67384185	67384185	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr16:67384185T>C	ENST00000329956.6	+	5	588	c.569T>C	c.(568-570)aTt>aCt	p.I190T	LRRC36_ENST00000563303.1_3'UTR|LRRC36_ENST00000290940.7_5'UTR|LRRC36_ENST00000541146.1_5'UTR|LRRC36_ENST00000563189.1_Missense_Mutation_p.I69T|LRRC36_ENST00000435835.3_Missense_Mutation_p.I69T	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	190										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GACAGCAGGATTGAAATGGGT	0.378000													14	77					0	0	1	0	0
CPT1B	1375	broad.mit.edu	37	22	51009808	51009808	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr22:51009808A>C	ENST00000360719.2	-	14	1873	c.1736T>G	c.(1735-1737)tTc>tGc	p.F579C	CPT1B_ENST00000440709.1_Missense_Mutation_p.F498C|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000457250.1_Missense_Mutation_p.F545C|CPT1B_ENST00000405237.3_Missense_Mutation_p.F579C|CPT1B_ENST00000434492.2_Missense_Mutation_p.F374C|CPT1B_ENST00000395650.2_Missense_Mutation_p.F579C|CPT1B_ENST00000312108.7_Missense_Mutation_p.F579C	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	579					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		TCCTACCCGGAAGTGAGCCAG	0.602000													16	55					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887677	12887677	+	Silent	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:12887677A>G	ENST00000535591.1	-	3	375	c.180T>C	c.(178-180)ctT>ctC	p.L60L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	60										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						CCAGCACTTGAAGTTTCCATC	0.463000													4	186					0	0	1	0	0
KIAA1430	57587	broad.mit.edu	37	4	186085310	186085310	+	Silent	SNP	G	G	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr4:186085310G>A	ENST00000458385.2	-	4	1463	c.1344C>T	c.(1342-1344)gcC>gcT	p.A448A		NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	448										endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		TTGGTTTCACGGCCTCAAGCC	0.393000													7	26					0	0	1	0	0
ZFP3	124961	broad.mit.edu	37	17	4996197	4996197	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr17:4996197A>G	ENST00000318833.3	+	2	1734	c.1398A>G	c.(1396-1398)atA>atG	p.I466M		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						AACTTATCATACATCAGAGAA	0.423000													10	48					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56527593	56527593	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr12:56527593C>T	ENST00000394048.5	+	13	1673	c.1409C>T	c.(1408-1410)tCt>tTt	p.S470F	ESYT1_ENST00000267113.4_Missense_Mutation_p.S470F|ESYT1_ENST00000541590.1_Missense_Mutation_p.S470F	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	470	C2 2.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						GGAGTCTCCTCTCGACCAGAT	0.552000													6	72					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	18					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181721292	181721292	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:181721292C>T	ENST00000526775.1	+	26	3853	c.3688C>T	c.(3688-3690)Cgg>Tgg	p.R1230W	CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1181W|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R1249W|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R856W|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R1230W|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R1200W|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R1249W	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1249	Poly-Val.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAACAAAGGACGGGACATCAA	0.483000													8	53					0	0	1	0	0
GTF2H3	2967	broad.mit.edu	37	12	124139496	124139496	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr12:124139496C>T	ENST00000543341.2	+	8	543	c.512C>T	c.(511-513)gCg>gTg	p.A171V	GTF2H3_ENST00000228955.7_Missense_Mutation_p.A130V	NM_001271867.1|NM_001516.3	NP_001258796.1|NP_001507.2	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3, 34kDa	171					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		GAAGACAGTGCGTTGCAGTAT	0.428000								Nucleotide excision repair (NER)					15	46					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358571	124358571	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr10:124358571C>T	ENST00000368909.3	+	26	3344	c.3238C>T	c.(3238-3240)Cac>Tac	p.H1080Y	DMBT1_ENST00000344338.3_Missense_Mutation_p.H1070Y|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Missense_Mutation_p.H581Y|DMBT1_ENST00000330163.4_Missense_Mutation_p.H581Y|DMBT1_ENST00000368955.3_Missense_Mutation_p.H1070Y|DMBT1_ENST00000338354.3_Missense_Mutation_p.H1080Y	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1080	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTGGCTCTCCCACAACTGTGG	0.567000													25	111					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24483789	24483789	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr1:24483789G>A	ENST00000327535.1	-	7	1406	c.1394C>T	c.(1393-1395)cCc>cTc	p.P465L	IFNLR1_ENST00000327575.2_3'UTR|IFNLR1_ENST00000374421.3_Missense_Mutation_p.P436L	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		AGAAACTGGGGGTCCCCCAGG	0.597000													12	67					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217347605	217347605	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr2:217347605G>A	ENST00000357276.4	+	18	3100	c.2770G>A	c.(2770-2772)Gac>Aac	p.D924N	AC098820.3_ENST00000453157.1_RNA|SMARCAL1_ENST00000358207.5_Missense_Mutation_p.D924N	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	924					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GAACATGGGAGACACCCTGGA	0.468000									Schimke Immuno-Osseous Dysplasia				27	97					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12257790	12257790	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr11:12257790G>A	ENST00000256194.4	+	16	2350	c.2062G>A	c.(2062-2064)Gag>Aag	p.E688K	MICAL2_ENST00000527546.1_Missense_Mutation_p.E688K|MICAL2_ENST00000342902.5_Missense_Mutation_p.E688K|MICAL2_ENST00000537344.1_Missense_Mutation_p.E688K|MICAL2_ENST00000379612.3_Missense_Mutation_p.E688K	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	688						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CAACCTGGACGAGGTTTGTGT	0.552000											OREG0020771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	43					0	0	1	0	0
RP11-167H9.4	0	broad.mit.edu	37	3	149769406	149769407	+	RNA	INS	-	-	C			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr3:149769406_149769407insC	ENST00000487840.1	+	0	46																											caagcaattctctgcctcagcc	0.515													2	4	---	---	---	---					
RP11-53I6.2	0	broad.mit.edu	37	18	29656287	29656288	+	RNA	INS	-	-	T			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr18:29656287_29656288insT	ENST00000583184.1	+	0	539																											ttgtttttttgttttttttttg	0.441													2	4	---	---	---	---					
TCF3	6929	broad.mit.edu	37	19	1611797	1611797	+	Frame_Shift_Del	DEL	T	T	-			TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr19:1611797delT	ENST00000262965.5	-	19	2218	c.1874delA	c.(1873-1875)agfs	p.K625fs	TCF3_ENST00000588136.1_Frame_Shift_Del_p.K622fs|TCF3_ENST00000344749.5_Frame_Shift_Del_p.K622fs|TCF3_ENST00000453954.2_Frame_Shift_Del_p.K537fs|TCF3_ENST00000395423.3_Frame_Shift_Del_p.K629fs	NM_003200.3	NP_003191.1	P15923	TFE2_HUMAN	transcription factor 3	625					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGACACCTTTTCCTCTTC	0.607			T	"""PBX1, HLF, TFPT"""	pre B-ALL								21	57	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-V1-A9ZG-01A-11D-A41K-08	TCGA-V1-A9ZG-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	463bc174-d782-4e0f-b8ab-e424b330c7f7	05454125-24ef-4c09-b1e9-71cd7a15a98e	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													4	4	---	---	---	---					
