Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ASPM	259266	broad.mit.edu	37	1	197061108	197061108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:197061108G>A	ENST00000367409.4	-	22	9629	c.9373C>T	c.(9373-9375)Caa>Taa	p.Q3125*	ASPM_ENST00000294732.7_Nonsense_Mutation_p.Q1540*|ASPM_ENST00000367408.1_Nonsense_Mutation_p.Q790*	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3125					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TAGGCTCTTTGAATTCTAACA	0.363000													20	51					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70034878	70034878	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr6:70034878C>T	ENST00000370598.1	+	21	3750	c.2929C>T	c.(2929-2931)Cgg>Tgg	p.R977W	BAI3_ENST00000238918.8_Missense_Mutation_p.R183W	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	977					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AATTAGGACACGGCTTATAAG	0.408000													30	71					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3599422	3599422	+	Silent	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr5:3599422C>T	ENST00000302006.3	+	2	412	c.360C>T	c.(358-360)taC>taT	p.Y120Y	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	120						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						ATTACCCCTACGGCCAGTTCC	0.657000													4	37					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51754523	51754523	+	Silent	SNP	G	G	A	rs138065864		TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr12:51754523G>A	ENST00000543196.2	-	6	1354	c.1149C>T	c.(1147-1149)aaC>aaT	p.N383N	GALNT6_ENST00000356317.3_Silent_p.N383N			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	383	Catalytic subdomain B.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.N383N(1)		endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						ACATTTCCACGTTCTCCCCTC	0.542000													19	37					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182395293	182395293	+	Missense_Mutation	SNP	T	T	C			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr2:182395293T>C	ENST00000397033.2	+	24	3011	c.2581T>C	c.(2581-2583)Tgt>Cgt	p.C861R		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	861					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TCAAAGAGTGTGTGCATTAGA	0.383000													23	51					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													3	51					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17283599	17283599	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr19:17283599G>A	ENST00000595618.1	+	13	2119	c.1967G>A	c.(1966-1968)cGg>cAg	p.R656Q	MYO9B_ENST00000594824.1_Missense_Mutation_p.R656Q|MYO9B_ENST00000397274.2_Missense_Mutation_p.R656Q	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	656	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						GACTACATGCGGCCAGACATC	0.667000													18	37					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55653269	55653269	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr11:55653269G>A	ENST00000449290.2	+	2	457	c.365G>A	c.(364-366)cGg>cAg	p.R122Q		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	122						intracellular	zinc ion binding										CAGGAGCACCGGAATCACATA	0.483000													15	41					0	0	1	0	0
PTPN23	25930	broad.mit.edu	37	3	47450483	47450483	+	Silent	SNP	C	C	T	rs151244361		TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr3:47450483C>T	ENST00000265562.4	+	16	1625	c.1548C>T	c.(1546-1548)caC>caT	p.H516H	PTPN23_ENST00000431726.1_Silent_p.H390H	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	516					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGAGCTGCACCGTGCCATGA	0.642000													9	77					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124765421	124765421	+	Missense_Mutation	SNP	A	A	G			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr11:124765421A>G	ENST00000306534.3	-	6	1453	c.968T>C	c.(967-969)gTg>gCg	p.V323A	ROBO4_ENST00000533054.1_Missense_Mutation_p.V178A	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	323	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGATGGTCTCACTTTGAACTC	0.642000													19	63					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568185	5568185	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr7:5568185G>A	ENST00000331789.5	-	4	720	c.529C>T	c.(529-531)Cgt>Tgt	p.R177C		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	177					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		AGGTCCAGACGCAGGATGGCA	0.647000													5	54					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80041237	80041237	+	Silent	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr17:80041237C>T	ENST00000306749.2	-	32	5624	c.5406G>A	c.(5404-5406)gaG>gaA	p.E1802E		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1802	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CAGCACTGCTCTCGTTGAAGA	0.647000													10	14					0	0	1	0	0
DDX1	1653	broad.mit.edu	37	2	15770187	15770187	+	Missense_Mutation	SNP	A	A	G			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr2:15770187A>G	ENST00000381341.2	+	26	2434	c.2045A>G	c.(2044-2046)gAt>gGt	p.D682G	DDX1_ENST00000233084.3_Missense_Mutation_p.D682G			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	682	Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GTACCAGTGGATGAATTTGAT	0.353000													30	103					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136507474	136507474	+	Missense_Mutation	SNP	C	C	T	rs143535251	byFrequency	TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr9:136507474C>T	ENST00000393056.2	+	3	644	c.632C>T	c.(631-633)gCg>gTg	p.A211V		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	211			A -> T (in dbSNP:rs5320).		hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCCTCAGACGCGTGCACCATG	0.607000													8	28					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354325	57354325	+	Missense_Mutation	SNP	T	T	C			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr8:57354325T>C	ENST00000314922.3	-	2	386	c.310A>G	c.(310-312)Atg>Gtg	p.M104V	PENK_ENST00000451791.2_Missense_Mutation_p.M104V|PENK_ENST00000523274.1_5'UTR	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	104					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TACCTTTTCATGAAGCCCCCA	0.493000													4	121					0	0	1	0	0
NANOG	79923	broad.mit.edu	37	12	7947285	7947285	+	Missense_Mutation	SNP	C	C	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr12:7947285C>A	ENST00000229307.4	+	4	731	c.512C>A	c.(511-513)gCa>gAa	p.A171E	NANOG_ENST00000526286.1_Intron	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	171					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		AAGGCCTCAGCACCTACCTAC	0.507000													9	11					0.00621372	0.00630786	1	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995989	57995989	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr11:57995989G>A	ENST00000316770.2	-	1	401	c.359C>T	c.(358-360)gCg>gTg	p.A120V		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				GGCCATGATCGCCAAGAGGAA	0.587000													7	19					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131908954	131908954	+	Silent	SNP	A	A	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr6:131908954A>T	ENST00000403834.3	-	29	4163	c.3990T>A	c.(3988-3990)gcT>gcA	p.A1330A	MED23_ENST00000545957.1_Silent_p.A965A|MED23_ENST00000368068.3_Silent_p.A1324A|MED23_ENST00000479213.1_5'UTR|MED23_ENST00000368060.3_Silent_p.A1324A|MED23_ENST00000368058.1_Silent_p.A1330A|MED23_ENST00000354577.4_Silent_p.A1330A			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	1324					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GAAGTTTTAAAGCTGGTTTTA	0.393000													5	10					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886182	57886182	+	Missense_Mutation	SNP	G	G	C			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr11:57886182G>C	ENST00000302610.1	-	1	734	c.735C>G	c.(733-735)atC>atG	p.I245M	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				CCACAGCAGTGATGTGAGAGG	0.468000													4	48					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657892	49657892	+	Silent	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr19:49657892C>T	ENST00000252825.4	-	1	789	c.603G>A	c.(601-603)gaG>gaA	p.E201E	HRC_ENST00000595625.1_Silent_p.E201E	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	201	4 X tandem repeats, acidic.|6 X approximate tandem repeats.|Glu-rich (acidic).				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		cctcctcttcctcctcctcct	0.557000													3	46					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14518782	14518782	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr3:14518782C>T	ENST00000454876.2	+	11	1608	c.1279C>T	c.(1279-1281)Cgt>Tgt	p.R427C	SLC6A6_ENST00000360861.3_Missense_Mutation_p.R427C			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	427					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity	p.R427C(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						GAAGGGTTATCGTCGGGAAAT	0.517000													28	51					0	0	1	0	0
CAPZA1	829	broad.mit.edu	37	1	113212672	113212672	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:113212672G>A	ENST00000263168.3	+	10	1451	c.779G>A	c.(778-780)cGg>cAg	p.R260Q	CAPZA1_ENST00000476936.1_3'UTR	NM_006135.2	NP_006126.1	P52907	CAZA1_HUMAN	capping protein (actin filament) muscle Z-line, alpha 1	260					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)	9	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTTGCGCCGGCAGCTTCCA	0.418000													18	49					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348668	197348668	+	RNA	SNP	C	C	G	rs79940815	by1000genomes	TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr3:197348668C>G	ENST00000418868.1	-	0	591					NR_003266.2																						ACTTGAGGCTCTGTCCACCAA	0.488000													4	102					0	0	1	0	0
PCDHB5	0	broad.mit.edu	37	5	140516147	140516147	+	Silent	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr5:140516147C>T	ENST00000231134.5	+	1	1348	c.1131C>T	c.(1129-1131)aaC>aaT	p.N377N		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		377	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.N377N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGGACAACGGTAGGATGA	0.483000													15	44					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185951499	185951499	+	Missense_Mutation	SNP	G	G	A	rs144772706		TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:185951499G>A	ENST00000271588.4	+	18	2997	c.2768G>A	c.(2767-2769)cGg>cAg	p.R923Q	HMCN1_ENST00000485744.1_3'UTR|HMCN1_ENST00000367492.2_Missense_Mutation_p.R923Q	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	923	Ig-like C2-type 6.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R923Q(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCAGAACGTCGGTGGATTAAG	0.378000													35	73					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203677049	203677049	+	Silent	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:203677049C>T	ENST00000357681.5	+	10	2497	c.1374C>T	c.(1372-1374)aaC>aaT	p.N458N	ATP2B4_ENST00000367219.3_Silent_p.N446N|ATP2B4_ENST00000341360.2_Silent_p.N458N|ATP2B4_ENST00000391954.2_Silent_p.N458N|ATP2B4_ENST00000367218.3_Silent_p.N458N	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	458					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCATGGGCAACGCCACCGCCA	0.473000													25	46					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115759948	115759948	+	RNA	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr9:115759948G>A	ENST00000427548.1	-	0	1865							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										CTCTGATGTCGGATTAGTGAT	0.413000													5	57					0	0	1	0	0
TRAV9-2	0	broad.mit.edu	37	14	22409639	22409639	+	RNA	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr14:22409639G>A	ENST00000390441.2	+	0	185																											TAAACTGCACGTACACAGCCA	0.488000													3	22					0	0	1	0	0
RP11-383M4.6	0	broad.mit.edu	37	9	84562526	84562526	+	RNA	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr9:84562526G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							TGCATGATCCGGAGACATCTT	0.488000													5	35					0	0	1	0	0
PHAX	51808	broad.mit.edu	37	5	125936738	125936738	+	Silent	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr5:125936738G>A	ENST00000297540.4	+	1	779	c.84G>A	c.(82-84)ccG>ccA	p.P28P	PHAX_ENST00000514725.1_3'UTR	NM_032177.3	NP_115553.2	Q9H814	PHAX_HUMAN	phosphorylated adaptor for RNA export	28	Necessary for interaction with CBP80 (By similarity).				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	8						GCGACAGGCCGCTGCAATTGC	0.677000													4	6					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56439945	56439945	+	Nonsense_Mutation	SNP	G	G	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr17:56439945G>T	ENST00000584437.1	-	5	2602	c.647C>A	c.(646-648)tCg>tAg	p.S216*	RNF43_ENST00000500597.2_Nonsense_Mutation_p.S175*|RNF43_ENST00000577716.1_Nonsense_Mutation_p.S216*|RNF43_ENST00000577625.1_Nonsense_Mutation_p.S89*|RNF43_ENST00000583753.1_Nonsense_Mutation_p.S175*|RNF43_ENST00000407977.2_Nonsense_Mutation_p.S216*|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000581868.1_Nonsense_Mutation_p.S89*			Q68DV7	RNF43_HUMAN	ring finger protein 43	216						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding	p.S216L(2)|p.S216*(1)		NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCGCAGCACCGAAGCCAGGAT	0.597000													7	35					1.06961e-07	1.15587e-07	1	1	0
HSPA2	3306	broad.mit.edu	37	14	65009231	65009231	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr14:65009231C>T	ENST00000247207.6	+	1	2046	c.1664C>T	c.(1663-1665)aCg>aTg	p.T555M	HSPA2_ENST00000394709.1_Missense_Mutation_p.T555M	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	555					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		ATCAAGCAGACGGTGGAAGAC	0.547000													13	35					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7804931	7804931	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:7804931G>A	ENST00000303635.7	+	17	4426	c.4219G>A	c.(4219-4221)Gcc>Acc	p.A1407T	CAMTA1_ENST00000439411.2_Missense_Mutation_p.A1407T	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CATTATTGAAGCCACACCTGA	0.463000			T	WWTR1	epitheliod hemangioendothelioma								14	53					0	0	1	0	0
PIPSL	0	broad.mit.edu	37	10	95720561	95720561	+	RNA	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr10:95720561G>A	ENST00000480546.1	-	0	736					NR_002319.2																						CATTTTTACCGATCTTGGTAA	0.458000													15	34					0	0	1	0	0
CAV1	857	broad.mit.edu	37	7	116198999	116198999	+	Splice_Site	SNP	G	G	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr7:116198999G>T	ENST00000341049.2	+	3	473		c.e3-1		CAV1_ENST00000393467.1_Splice_Site|CAV1_ENST00000393468.1_Splice_Site|CAV1_ENST00000405348.1_Splice_Site|CAV1_ENST00000393470.1_Splice_Site	NM_001753.4	NP_001744.2	Q03135	CAV1_HUMAN	caveolin 1, caveolae protein, 22kDa						blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			CTTCCTTTTAGATTGACTTTG	0.393000													11	27					0.000673444	0.000694165	1	1	0
POSTN	10631	broad.mit.edu	37	13	38164612	38164612	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr13:38164612G>A	ENST00000379747.4	-	4	455	c.338C>T	c.(337-339)aCg>aTg	p.T113M	POSTN_ENST00000379743.4_Missense_Mutation_p.T113M|POSTN_ENST00000379749.4_Missense_Mutation_p.T113M|POSTN_ENST00000541179.1_Missense_Mutation_p.T113M|POSTN_ENST00000379742.4_Missense_Mutation_p.T113M|POSTN_ENST00000541481.1_Missense_Mutation_p.T113M	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	113	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ATAGCGCTGCGTTGTGGTGGC	0.473000													7	24					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638882	113638882	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:113638882C>T	ENST00000361127.4	+	8	1184	c.986C>T	c.(985-987)tCt>tTt	p.S329F		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	329						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CTGGATGAATCTGCCTTTGTG	0.383000													19	92					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21228048	21228048	+	Missense_Mutation	SNP	G	G	C	rs141448576	byFrequency	TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr9:21228048G>C	ENST00000413767.2	-	1	173	c.125C>G	c.(124-126)gCa>gGa	p.A42G		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	42					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCCCATTTGTGCCAGGAGTAT	0.517000													19	105					0	0	1	0	0
TNFRSF8	0	broad.mit.edu	37	1	12198401	12198401	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:12198401C>T	ENST00000263932.2	+	14	1673	c.1451C>T	c.(1450-1452)cCg>cTg	p.P484L	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.P372L|TNFRSF8_ENST00000479933.2_Intron|TNFRSF8_ENST00000413146.2_Missense_Mutation_p.P21L	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	484					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAGCCTGCCGCTGCAGGAT	0.662000													7	27					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730969	100730969	+	Missense_Mutation	SNP	G	G	C			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr7:100730969G>C	ENST00000306085.6	+	3	673	c.376G>C	c.(376-378)Gac>Cac	p.D126H		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	126					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGTGCCGATGACTTGTGCCA	0.716000													7	24					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													5	57					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668843	17668843	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:17668843C>T	ENST00000375448.4	+	8	907	c.881C>T	c.(880-882)gCg>gTg	p.A294V	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	294					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TTCCGCGTGGCGCCCTGGATC	0.677000													9	34					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150529231	150529231	+	Missense_Mutation	SNP	T	T	C			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:150529231T>C	ENST00000271643.4	+	10	1947	c.1711T>C	c.(1711-1713)Tcg>Ccg	p.S571P	ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.S594P|RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.S571P|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.S571P	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	571					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGAGAGTCTGTCGGCTGAAGG	0.652000													25	112					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33998700	33998700	+	Missense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr1:33998700C>T	ENST00000373381.4	-	64	10297	c.10121G>A	c.(10120-10122)cGc>cAc	p.R3374H		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3230						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTTGCAGGTGCGGTGCTCGGA	0.657000													8	22					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152529086	152529086	+	Missense_Mutation	SNP	A	A	G			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr2:152529086A>G	ENST00000427231.2	-	37	4298	c.4096T>C	c.(4096-4098)Tct>Cct	p.S1366P	NEB_ENST00000409198.1_Missense_Mutation_p.S1366P|NEB_ENST00000397345.3_Missense_Mutation_p.S1366P|NEB_ENST00000172853.10_Missense_Mutation_p.S1366P|NEB_ENST00000604864.1_Missense_Mutation_p.S1366P|NEB_ENST00000603639.1_Missense_Mutation_p.S1366P	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1366					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACGATCAGACTGCAGCTTT	0.478000													29	67					0	0	1	0	0
C17orf66	256957	broad.mit.edu	37	17	34192290	34192290	+	Nonsense_Mutation	SNP	C	C	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr17:34192290C>T	ENST00000311880.2	-	3	397	c.249G>A	c.(247-249)tgG>tgA	p.W83*	C17orf66_ENST00000592980.1_Nonsense_Mutation_p.W83*|C17orf66_ENST00000587585.1_5'UTR	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	83							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		ACAGGTCGTGCCAGTGCGTGT	0.502000													6	23					0	0	1	0	0
SPATS2	65244	broad.mit.edu	37	12	49888746	49888746	+	Missense_Mutation	SNP	G	G	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr12:49888746G>T	ENST00000553127.1	+	8	1000	c.487G>T	c.(487-489)Gat>Tat	p.D163Y	SPATS2_ENST00000552918.1_Missense_Mutation_p.D163Y|SPATS2_ENST00000552557.1_3'UTR|SPATS2_ENST00000321898.6_Missense_Mutation_p.D163Y			Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	163						cytoplasm				breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|prostate(1)|urinary_tract(4)	21						AGAATTGGAGGATCCCGAGTC	0.438000													8	42					0.000274275	0.000287132	1	1	0
SBF1	6305	broad.mit.edu	37	22	50900074	50900074	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr22:50900074G>A	ENST00000380817.2	-	22	2900	c.2717C>T	c.(2716-2718)cCg>cTg	p.P906L	SBF1_ENST00000390679.3_Missense_Mutation_p.P906L|SBF1_ENST00000348911.6_Missense_Mutation_p.P907L	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	906	GRAM.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		ACGCCCATCCGGCAGCAGGTA	0.682000													3	18					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16003207	16003207	+	Missense_Mutation	SNP	C	C	T	rs61755872	byFrequency	TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr19:16003207C>T	ENST00000221700.5	-	5	532	c.437G>A	c.(436-438)cGc>cAc	p.R146H	CYP4F2_ENST00000011989.7_5'UTR|CYP4F2_ENST00000592328.1_Missense_Mutation_p.R146H	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	146					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CCGACGGTGGCGGCTCCACTT	0.562000													15	56					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46652736	46652736	+	Missense_Mutation	SNP	C	C	T	rs76372072	byFrequency	TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr22:46652736C>T	ENST00000253255.5	-	1	6483	c.6484G>A	c.(6484-6486)Gtc>Atc	p.V2162I		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	2162					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTGATCAAGACGCAGATCATC	0.438000													14	47					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52525926	52525926	+	Missense_Mutation	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr3:52525926G>A	ENST00000345716.4	+	21	4077	c.3943G>A	c.(3943-3945)Gtc>Atc	p.V1315I	NISCH_ENST00000479054.1_Missense_Mutation_p.V1315I	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1315					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CTCTAGTCGCGTCAAGTTTAC	0.597000													3	61					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	10274038	10274038	+	Silent	SNP	G	G	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr16:10274038G>A	ENST00000396573.2	-	3	540	c.231C>T	c.(229-231)acC>acT	p.T77T	GRIN2A_ENST00000404927.2_Silent_p.T77T|GRIN2A_ENST00000562109.1_Silent_p.T77T|GRIN2A_ENST00000330684.3_Silent_p.T77T|GRIN2A_ENST00000396575.2_Silent_p.T77T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	77					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTTGGGGTCGGTGCGGTTCA	0.667000													33	80					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447623	226447623	+	Missense_Mutation	SNP	C	C	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr2:226447623C>A	ENST00000272907.6	+	4	1903	c.1490C>A	c.(1489-1491)gCa>gAa	p.A497E	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	497																	ACCTACGGGGCAGCCCCGGGT	0.677000													6	34					0.248553	0.248553	1	1	0
SEMA5A	9037	broad.mit.edu	37	5	9122875	9122875	+	Silent	SNP	G	G	A	rs141153482		TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr5:9122875G>A	ENST00000382496.5	-	14	2339	c.1674C>T	c.(1672-1674)agC>agT	p.S558S		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	558	TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						ATCCCACGGCGCTGCCATCTG	0.637000													7	65					0	0	1	0	0
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													5	4	---	---	---	---					
SAMD9	54809	broad.mit.edu	37	7	92732960	92732960	+	Frame_Shift_Del	DEL	A	A	-			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr7:92732960delA	ENST00000379958.2	-	3	2720	c.2451delT	c.(2449-2451)gcfs	p.A817fs		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	817						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTAGCTATAGCTGTTTGAA	0.368													26	82	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49444975	49444976	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr12:49444975_49444976delAT	ENST00000301067.7	-	10	2489_2490	c.2490_2491delAT	c.(2488-2493)gacafs	p.ES830fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GACAGGTGTGATTCCTCAGGTT	0.644													21	68	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124957641	124957642	+	Frame_Shift_Ins	INS	-	-	A			TCGA-X4-A8KQ-01A-12D-A364-08	TCGA-X4-A8KQ-10A-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04ded7a3-d7f2-43a0-9124-6e5a89a0013c	88958ce2-ad68-4691-967e-716477ec338a	g.chr12:124957641_124957642insA	ENST00000356219.3	-	5	602_603	c.447_448insT	c.(445-450)tcccccfs	p.SP149fs	NCOR2_ENST00000404621.1_Frame_Shift_Ins_p.SP149fs|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000397355.1_Frame_Shift_Ins_p.SP149fs|NCOR2_ENST00000429285.2_Frame_Shift_Ins_p.SP149fs|NCOR2_ENST00000405201.1_Frame_Shift_Ins_p.SP149fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	149					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGCTGGGGGGAGACACCGGTT	0.639													17	43	---	---	---	---					
